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M  END
> <ID>
CHEBI:15647

> <NAME>
leukotriene B4

> <DEFINITION>
A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.

> <STAR>
3

> <SECONDARY_ID>
CHEBI:6421; CHEBI:10933; CHEBI:25024

> <SYNONYM>
LTB4; LTB4; LTB4; Leukotriene B4; 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; 5S,12R-diHETE; 5,12-Hete; 5,12-Dihete; 5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-icosatetraenoic acid; 5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid; (S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid; (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid; (5S,12R,6Z,8E,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid

> <IUPAC_NAME>
(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid

> <FORMULA>
C20H32O4

> <MASS>
336.472

> <MONOISOTOPIC_MASS>
336.23006

> <CHARGE>
0

> <SMILES>
CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O

> <INCHI>
InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1

> <INCHIKEY>
VNYSSYRCGWBHLG-AMOLWHMGSA-N

> <CAS_REGISTRY_NUMBER>
71160-24-2

> <REAXYS_REGISTRY_NUMBER>
4235309

> <CHEMIDPLUS>
71160-24-2

> <DRUGBANK_ACCESSION>
DB12961

> <KEGG_COMPOUND_ACCESSION>
C02165

> <KNAPSACK_ACCESSION>
C00053425

> <LIPID_MAPS_INSTANCE_ACCESSION>
LMFA03020001

> <PDBECHEM_ACCESSION>
LTB

> <WIKIPEDIA_ACCESSION>
Leukotriene_B4

> <PUBMED_CITATION>
10087000; 10391868; 10695938; 11166796; 11254552; 12709426; 12742837; 12947016; 1327049; 1333134; 1335872; 1338371; 15016629; 15515787; 16567388; 1661709; 17481557; 17548641; 17623009; 1847289; 20400503; 20529300; 20671299; 23625922; 32439596; 32960415; 33292560; 33612149; 6271967; 7924852; 8243477; 8382716; 8397308; 9209678; 9516893; 9606840

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