Marvin 02071310462D 54 58 0 0 1 0 999 V2000 11.4224 -5.5160 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 11.4224 -6.3410 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1236 -5.1035 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7211 -5.1035 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.8661 -5.5160 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0199 -5.5160 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5674 -5.1035 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 9.2774 -5.1035 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 10.0199 -6.3410 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 13.5674 -4.2785 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2687 -5.4748 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.5761 -5.5160 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.8249 -3.8660 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.9699 -5.1035 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8749 -5.1035 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8249 -3.0410 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1236 -4.2785 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7124 -5.4748 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 14.9699 -4.2785 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.1736 -5.5160 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.8749 -4.2785 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.1236 -2.6285 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4224 -3.8660 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.4137 -5.0623 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4311 -5.1035 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1736 -6.3410 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4224 -3.0410 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1149 -5.4748 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7298 -5.5160 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.1149 -6.2998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8987 -5.2273 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 4.9461 -5.3098 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.7298 -6.3410 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 17.8987 -6.5473 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 18.3937 -5.8873 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4923 -6.0110 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9873 -6.6298 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 3.6673 -6.0110 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2136 -5.3098 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2961 -6.7123 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1369 -6.7535 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.1369 -7.5784 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8514 -7.9909 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5659 -7.5784 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.5659 -6.7535 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.8514 -6.3410 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2673 -4.2786 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5555 -3.8792 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5555 -3.0542 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.2598 -2.6472 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.2595 -1.8221 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.5449 -1.4100 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.8405 -1.8169 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8408 -2.6419 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 6 0 0 0 1 3 1 0 0 0 0 1 4 1 0 0 0 0 3 5 1 0 0 0 0 4 6 1 0 0 0 0 5 7 1 0 0 0 0 6 8 1 0 0 0 0 6 9 2 0 0 0 0 7 10 1 6 0 0 0 7 11 1 0 0 0 0 8 12 1 1 0 0 0 10 13 1 0 0 0 0 11 14 1 0 0 0 0 12 15 1 0 0 0 0 13 16 2 0 0 0 0 13 17 1 0 0 0 0 14 18 1 0 0 0 0 14 19 2 0 0 0 0 15 20 1 0 0 0 0 15 21 2 0 0 0 0 16 22 1 0 0 0 0 17 23 2 0 0 0 0 18 24 1 0 0 0 0 20 25 1 0 0 0 0 20 26 1 0 0 0 0 22 27 2 0 0 0 0 24 28 1 0 0 0 0 25 29 1 0 0 0 0 28 30 2 0 0 0 0 28 31 1 0 0 0 0 29 32 1 0 0 0 0 29 33 2 0 0 0 0 30 34 1 0 0 0 0 31 35 1 0 0 0 0 32 36 2 0 0 0 0 33 37 1 0 0 0 0 36 38 1 0 0 0 0 38 39 1 0 0 0 0 38 40 1 0 0 0 0 23 27 1 0 0 0 0 34 35 2 0 0 0 0 36 37 1 0 0 0 0 2 41 1 0 0 0 0 41 42 2 0 0 0 0 42 43 1 0 0 0 0 43 44 2 0 0 0 0 44 45 1 0 0 0 0 45 46 2 0 0 0 0 41 46 1 0 0 0 0 8 47 1 0 0 0 0 47 48 1 0 0 0 0 48 49 1 0 0 0 0 49 50 1 0 0 0 0 50 51 1 0 0 0 0 51 52 1 0 0 0 0 52 53 1 0 0 0 0 53 54 1 0 0 0 0 49 54 1 0 0 0 0 M END > CHEBI:72291 > cobicistat > A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications.. > 3 > GS-9350; GS 9350 > 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate > cobicistatum; cobicistat; cobicistat; cobicistat > C40H53N7O5S2 > 776.02300 > 775.35496 > 0 > CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1 > InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1 > ZCIGNRJZKPOIKD-CQXVEOKZSA-N > 1004316-88-4 > 13088386 > 1004316-88-4 > Cobicistat > 20043009; 20683270; 21348537; 22732469; 22766666; 22833060; 22850510; 22886031; 23136357; 23243633 $$$$