ChEBI logo

ChEBI


    The database and ontology of Chemical Entities of Biological Interest

spacer

tamoxifen (CHEBI:41774)

Search for only All in ChEBI

Main     ChEBI Ontology     Automatic Xrefs      
ChEBI Name tamoxifen
ChEBI ID CHEBI:41774
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:41767, CHEBI:9396
Supplier Information
See structure as:  Image  Applet
Save molfile Download Molfile
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula Source
C26H29NO KEGG COMPOUND
Net Charge 0
Average Mass 371.51460
InChI
InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
InChIKey
NKANXQFJJICGDU-QPLCGJKRSA-N
SMILES
CC\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1
Roles Classification
Chemical Role(s): EC 1.2.3.1 (aldehyde oxidase) inhibitor
An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1).
EC 2.7.11.13 (protein kinase C) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
Biological Role(s): estrogen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
EC 1.2.3.1 (aldehyde oxidase) inhibitor
An EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor which interferes with the action of aldehyde oxidase (EC 1.2.3.1).
estrogen receptor antagonist
An antagonist at the estrogen receptor.
EC 2.7.11.13 (protein kinase C) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
Application(s): estrogen antagonist
A compound which inhibits or antagonises the biosynthesis or actions of estrogens.
estrogen receptor modulator
A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure.
bone density conservation agent
An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
estrogen receptor antagonist
An antagonist at the estrogen receptor.
angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more on the ChEBI Ontology
ChEBI Ontology
Outgoing tamoxifen (CHEBI:41774) has parent hydride stilbene (CHEBI:26775)
tamoxifen (CHEBI:41774) has role angiogenesis inhibitor (CHEBI:48422)
tamoxifen (CHEBI:41774) has role antineoplastic agent (CHEBI:35610)
tamoxifen (CHEBI:41774) has role bone density conservation agent (CHEBI:50646)
tamoxifen (CHEBI:41774) has role EC 1.2.3.1 (aldehyde oxidase) inhibitor (CHEBI:62872)
tamoxifen (CHEBI:41774) has role EC 2.7.11.13 (protein kinase C) inhibitor (CHEBI:37700)
tamoxifen (CHEBI:41774) has role estrogen antagonist (CHEBI:50837)
tamoxifen (CHEBI:41774) has role estrogen receptor antagonist (CHEBI:50792)
tamoxifen (CHEBI:41774) has role estrogen receptor modulator (CHEBI:50739)
tamoxifen (CHEBI:41774) is a stilbenoid (CHEBI:26776)
tamoxifen (CHEBI:41774) is a tertiary amino compound (CHEBI:50996)
Incoming afimoxifene (CHEBI:44616) has functional parent tamoxifen (CHEBI:41774)
tamoxifen N-oxide (CHEBI:63825) has functional parent tamoxifen (CHEBI:41774)
tamoxifen citrate (CHEBI:9397) has part tamoxifen (CHEBI:41774)
IUPAC Name
2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine
INNs Sources
tamoxifen ChemIDplus
tamoxifène ChemIDplus
tamoxifeno ChemIDplus
tamoxifenum ChemIDplus
Synonyms Sources
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine ChemIDplus
(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine ChemIDplus
1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene ChemIDplus
1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene ChemIDplus
Tamoxifen KEGG COMPOUND
trans-Tamoxifen ChemIDplus
Brand Names Sources
Apo-Tamox DrugBank
Citofen Deprecated term DrugBank
Crisafeno DrugBank
Diemon DrugBank
Gen-Tamoxifen Deprecated term DrugBank
Istubol Deprecated term DrugBank
Noltam Deprecated term DrugBank
Nourytam Deprecated term DrugBank
Oncomox Deprecated term DrugBank
Retaxim Deprecated term DrugBank
Tamofen Deprecated term DrugBank
Tamone Deprecated term DrugBank
Tamoxasta Deprecated term DrugBank
Valodex Deprecated term DrugBank
Zemide Deprecated term DrugBank
Database Links Databases
BE637389 Patent
BE678807 Patent
C07108 KEGG COMPOUND
D08559 KEGG DRUG
DB00675 DrugBank
HMDB14813 HMDB
Tamoxifen Wikipedia
US4536516 Patent
View more database links
Registry Numbers Types Sources
10540-29-1 CAS Registry Number ChemIDplus
2062020 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
14681337 PubMed citation CiteXplore
14709804 PubMed citation CiteXplore
18348622 PubMed citation CiteXplore
7688593 PubMed citation CiteXplore
Last Modified
18 marzo 2014

spacer
spacer