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01 September 2014 - ChEBI release 119 is now available

ChEBI release 119 is now available, with 40536 fully annotated entities.

See our entity of the month, maytansine.
http://www.ebi.ac.uk/chebi/entityMonthForward.do

With kind regards,
the ChEBI team

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04 August 2014 - ChEBI release 118 is now available

ChEBI release 118 is now available, with 40211 fully annotated entities.

See our entity of the month, Psilocybin.
http://www.ebi.ac.uk/chebi/entityMonthForward.do

With kind regards,
the ChEBI team

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Molekül des Monats
1st September 2014
maytansine

First isolated in 1972 from the African plant Maytenus ovatus, later named Maytenus serrata, by Professor S. Morris Kupchan and co-workers at the University of Virginia using bioassay-guided methods, the 19-membered macrolactam maytansine (CHEBI:6701) was found to combine broad spectrum antitumour activity with extraordinarily high potency [1]. However, it took a further five years before a more efficient isolation procedure was developed using M. buchananii and sufficient quantities of maytansine became available to enable clinical trials to proceed. In the meantime, with funding particularly from the US National Cancer Institute, a number of closely related compounds known as 'maytansinoids' were isolated from members of the bittersweet (Celastraceae), buckthorn (Rhamnaceae), and spurge (Euphorbiaceae) plant families. Unfortunately, early hopes that maytansine or maytansinoids could be readily developed into a clinically useful anticancer drug were dashed by disappointing Phase II clinical trials, probably a result of the dose-limiting cytotoxicity of the maytansinoids in humans.

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Chemical Entities of Biological Interest (ChEBI) ist ein freies Lexikon über molekulare Entitäten mit Hauptaugenmerk auf chemische Verbindungen.
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