CHEBI:28445 - vincristine

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ChEBI Name vincristine
ChEBI ID CHEBI:28445
Definition A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:27289, CHEBI:9987
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
tubulin modulator
Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
microtubule-destabilising agent
Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
drug
Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
Related Structures
vincristine is a Structural Derivative of
vincaleukoblastine
Mass : 810.97410
Formula : C46H58N4O9
27375 		methanol
Mass : 32.04186
Formula : CH4O
17790 		acetic acid
Mass : 60.05200
Formula : C2H4O2
15366 		ammonia
Mass : 17.03056
Formula : H3N
16134
vincristine is a Conjugate Base of
vincristine(2+)
Mass : 826.987
Formula : C46H58N4O10
143658
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