CHEBI:50276 - EC 5.99.1.2 (DNA topoisomerase) inhibitor

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ChEBI Name EC 5.99.1.2 (DNA topoisomerase) inhibitor
ChEBI ID CHEBI:50276
Definition A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Stars This entity has been manually annotated by the ChEBI Team.
Members of EC 5.99.1.2 (DNA topoisomerase) inhibitor Class Download as Tab-delimited, XML, SDF
amarogentin
Mass :586.54070
Formula : C29H30O13
disulfiram
Mass :296.544
Formula : C10H20N2S4
feruloylagmatine
Mass :306.36020
Formula : C15H22N4O3
topopyrone C
Mass :338.26780
Formula : C18H10O7
topopyrone D
Mass :338.26780
Formula : C18H10O7
kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside
Mass :606.52880
Formula : C28H30O15
kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside
Mass :740.65930
Formula : C33H40O19
kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside
Mass :564.49210
Formula : C26H28O14
(S)-scoulerine
Mass :327.37438
Formula : C19H21NO4
topopyrone A
Mass :372.71300
Formula : C18H9ClO7
topopyrone B
Mass :372.71300
Formula : C18H9ClO7
dihydrobetulinic acid
Mass :458.71620
Formula : C30H50O3
topotecan
Mass :421.44580
Formula : C23H23N3O5
lucanthone
Mass :340.48200
Formula : C20H24N2OS
diflomotecan
Mass :398.366
Formula : C21H16F2N2O4
(R)-homocamptothecin
Mass :362.385
Formula : C21H18N2O4
ellagic acid
Mass :302.194
Formula : C14H6O8
SN-38
Mass :392.411
Formula : C22H20N2O5
manoalide
Mass :416.55030
Formula : C25H36O5
rubitecan
Mass :393.350
Formula : C20H15N3O6
irinotecan hydrochloride hydrate
Mass :677.186
Formula : C33H45ClN4O9
irinotecan hydrochloride (anhydrous)
Mass :623.140
Formula : C33H39ClN4O6
irinotecan
Mass :586.679
Formula : C33H38N4O6
kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside
Mass :740.65930
Formula : C33H40O19
kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside
Mass :594.51810
Formula : C27H30O15
kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside
Mass :594.51810
Formula : C27H30O15
saintopin
Mass :338.268
Formula : C18H10O7
camptothecin
Mass :348.35200
Formula : C20H16N2O4
methyl brevifolincarboxylate
Mass :306.22440
Formula : C14H10O8
morin
Mass :302.23570
Formula : C15H10O7
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