CHEBI:50750 - EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor

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ChEBI Name EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
ChEBI ID CHEBI:50750
Definition A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:132229, CHEBI:50234
Members of EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor Class Download as Tab-delimited, XML, SDF
genistein
Mass :270.240
Formula : C15H10O5
dextrofloxacin
Mass :361.373
Formula : C18H20FN3O4
levofloxacin
Mass :361.373
Formula : C18H20FN3O4
ofloxacin
Mass :361.373
Formula : C18H20FN3O4
ciprofloxacin hydrochloride (anhydrous)
Mass :367.80200
Formula : C17H19ClFN3O3
ciprofloxacin hydrochloride hydrate
Mass :385.81800
Formula : C17H21ClFN3O4
ciprofloxacin dihydrochloride
Mass :404.26300
Formula : C17H20Cl2FN3O3
novobiocin
Mass :612.62430
Formula : C31H36N2O11
procyanidin B4
Mass :578.52020
Formula : C30H26O12
aclacinomycin A
Mass :811.86790
Formula : C42H53NO15
betulinic acid
Mass :456.70030
Formula : C30H48O3
kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside
Mass :606.52880
Formula : C28H30O15
kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside
Mass :564.49210
Formula : C26H28O14
temafloxacin
Definition : A racemate comprising equimolar amounts of (R)- and (S)-temafloxacin. Both enantiomers both exhibit similar pharmacological profiles. Temafloxacin was briefly used (either as the free base or as the hydrochloride salt) as an antibacterial drug but was withdrawn worldwide in 1992 following reports of serious side effects, including severe hypoglycaemia, haemolytic anaemia, liver and kidney dysfunction, anaphylaxis, and death.
(R)-temafloxacin
Mass :417.38110
Formula : C21H18F3N3O3
(S)-temafloxacin
Mass :417.38110
Formula : C21H18F3N3O3
gatifloxacin
Mass :375.39410
Formula : C19H22FN3O4
4'-epidoxorubicin
Mass :543.51930
Formula : C27H29NO11
dihydrobetulinic acid
Mass :458.71620
Formula : C30H50O3
fleroxacin
Mass :369.339
Formula : C17H18F3N3O3
teniposide
Mass :656.660
Formula : C32H32O13S
maleimide
Mass :97.07210
Formula : C4H3NO2
lucanthone
Mass :340.48200
Formula : C20H24N2OS
fisetin
Mass :286.23630
Formula : C15H10O6
celastrol
Mass :450.60960
Formula : C29H38O4
TOP-53
Mass :512.596
Formula : C28H36N2O7
ellagic acid
Mass :302.194
Formula : C14H6O8
nepalensinol E
Mass :924.94080
Formula : C56H44O13
aclacinomycin A zwitterion
Mass :811.86790
Formula : C42H53NO15
manoalide
Mass :416.55030
Formula : C25H36O5
amsacrine
Mass :393.45900
Formula : C21H19N3O3S
kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside
Mass :594.51810
Formula : C27H30O15
kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside
Mass :564.49210
Formula : C26H28O14
nepalensinol D
Mass :698.71340
Formula : C42H34O10
nepalensinol F
Mass :906.92550
Formula : C56H42O12
ICRF-193
Mass :282.296
Formula : C12H18N4O4
ciprofloxacin
Mass :331.34150
Formula : C17H18FN3O3
4,4'-propane-1,3-diyldipiperazine-2,6-dione
Mass :268.26930
Formula : C11H16N4O4
flumequine
Definition : A racemate comprising equimolar amounts of R- and S-flumequine. A broad-spectrum antibiotic, formerly used in veterinary medicine for stock breeding and treatment of aquacultures.
wedelolactone
Mass :314.24640
Formula : C16H10O7
methyl brevifolincarboxylate
Mass :306.22440
Formula : C14H10O8
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