toxoflavin (CHEBI:80729)

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ChEBI Name	toxoflavin

ChEBI ID	CHEBI:80729

Definition	A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C7H7N5O2

Net Charge

Average Mass

193.163

Monoisotopic Mass

193.05997

InChI

InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3

InChIKey

SLGRAIAQIAUZAQ-UHFFFAOYSA-N

SMILES

N1=CN=C2C(N1C)=NC(N(C2=O)C)=O

Metabolite of Species	Details
Burkholderia gladioli (NCBI:txid28095)	See: PubMed
Burkholderia glumae (NCBI:txid337)	See: Jeong, Y., Kim, J., Kim, S., and Kang, Y (2003). Toxoflavin Produced by Burkholderia glumae Causing Rice Grain Rot Is Responsible for Inducing Bacterial Wilt in Many Field Crops. Plant Disease, Vol. 87 (8). p 890-895.

Roles Classification
Biological Role(s):	toxin Poisonous substance produced by a biological organism such as a microbe, animal or plant. Wnt signalling inhibitor A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. virulence factor Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	toxoflavin (CHEBI:80729) has functional parent reumycin (CHEBI:121196) toxoflavin (CHEBI:80729) has role antibacterial agent (CHEBI:33282) toxoflavin (CHEBI:80729) has role antineoplastic agent (CHEBI:35610) toxoflavin (CHEBI:80729) has role apoptosis inducer (CHEBI:68495) toxoflavin (CHEBI:80729) has role bacterial metabolite (CHEBI:76969) toxoflavin (CHEBI:80729) has role toxin (CHEBI:27026) toxoflavin (CHEBI:80729) has role virulence factor (CHEBI:72316) toxoflavin (CHEBI:80729) has role Wnt signalling inhibitor (CHEBI:78031) toxoflavin (CHEBI:80729) is a carbonyl compound (CHEBI:36586) toxoflavin (CHEBI:80729) is a pyrimidotriazine (CHEBI:131697)

IUPAC Name

1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione

Synonyms	Sources
1,6-dimethylpyrimido(5,4-e)-as-triazine-5,7(1H,6H)-dione	ChemIDplus
1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione	ChEBI
1-methylreumycin	ChEBI
NC72	ChEBI
NSC67078	ChEBI
PKF118-310	ChEBI
toxoflavin	UniProt
toxoflavine	ChEBI
xanthothricin	MetaCyc
xanthotricin	ChemIDplus

Last Modified

19 October 2018