diphenylpyraline (CHEBI:59788)

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ChEBI Name	diphenylpyraline

ChEBI ID	CHEBI:59788

Definition	A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C19H23NO

Net Charge

Average Mass

281.39200

Monoisotopic Mass

281.17796

InChI

InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3

InChIKey

OWQUZNMMYNAXSL-UHFFFAOYSA-N

SMILES

CN1CCC(CC1)OC(c1ccccc1)c1ccccc1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

Application(s):	H1-receptor antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. cholinergic antagonist Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.

ChEBI Ontology
Outgoing	diphenylpyraline (CHEBI:59788) has role cholinergic antagonist (CHEBI:48873) diphenylpyraline (CHEBI:59788) has role H₁-receptor antagonist (CHEBI:37955) diphenylpyraline (CHEBI:59788) is a piperidines (CHEBI:26151) diphenylpyraline (CHEBI:59788) is a tertiary amine (CHEBI:32876)

Incoming	diphenylpyraline hydrochloride (CHEBI:31508) has part diphenylpyraline (CHEBI:59788)

IUPAC Name

4-(diphenylmethoxy)-1-methylpiperidine

Synonyms	Sources
1-methyl-4-hydroxypiperidine benzhydryl ether	ChEBI
1-methyl-4-piperidyl benzhydryl ether	ChemIDplus
4-(benzhydryloxy)-1-methylpiperidine	ChemIDplus
4-(benzhydryloxy)-N-methylpiperidine	ChEBI
diphenylpyralamine	DrugBank

Last Modified

22 February 2017