1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598)

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ChEBI Name	1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one

ChEBI ID	CHEBI:64598

Definition	A differentiation-inducing factor that is hexaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls cell fate during development of Dictyostelium cells.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Rebecca Foulger

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Formula

C13H16Cl2O4

Net Charge

Average Mass

307.170

Monoisotopic Mass

306.04256

InChI

InChI=1S/C13H16Cl2O4/c1-3-4-5-6-7(16)8-11(17)9(14)13(19-2)10(15)12(8)18/h17-18H,3-6H2,1-2H3

InChIKey

VUDQSRFCCHQIIU-UHFFFAOYSA-N

SMILES

C(CCCCC)(=O)C1=C(C(=C(C(=C1O)Cl)OC)Cl)O

Metabolite of Species	Details
Dictyostelium (NCBI:txid5782)	See: PubMed

Roles Classification
Biological Role(s):	signalling molecule A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell. eukaryotic metabolite Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms. (via differentiation-inducing factor ) effector A small molecule which increases (activator) or decreases (inhibitor) the activity of an (allosteric) enzyme by binding to the enzyme at the regulatory site (which is different from the substrate-binding catalytic site). (via differentiation-inducing factor )

ChEBI Ontology
Outgoing	1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) has functional parent (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one (CHEBI:90396) 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) has role eukaryotic metabolite (CHEBI:75763) 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) has role signalling molecule (CHEBI:62488) 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a dichlorobenzene (CHEBI:23697) 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a differentiation-inducing factor (CHEBI:64672) 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a monomethoxybenzene (CHEBI:25235) 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is a resorcinols (CHEBI:33572) 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598) is conjugate acid of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one(1−) (CHEBI:90397)

Incoming	1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one(1−) (CHEBI:90397) is conjugate base of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (CHEBI:64598)

IUPAC Name

1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one

Synonyms	Sources
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone	ChemIDplus
C13H16Cl2O4	SUBMITTER
DIF 1	ChEBI
DIF-1	SUBMITTER
Dif-1 (dictyostelium)	ChemIDplus
Differentiation-inducing factor 1	SUBMITTER
differentiation-inducing factor-1	SUBMITTER
Morphogen differentiation inducing factor (dictyostelium)	ChemIDplus

Manual Xref	Database
Differentiation-inducing_factor	Wikipedia
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Last Modified

24 January 2017