ID   BMP2_MOUSE              Reviewed;         394 AA.
AC   P21274;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   24-NOV-2009, entry version 91.
DE   RecName: Full=Bone morphogenetic protein 2;
DE            Short=BMP-2;
DE   AltName: Full=BMP-2A;
DE   Flags: Precursor;
GN   Name=Bmp2; Synonyms=Bmp-2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=94289485; PubMed=8018727; DOI=10.1016/0167-4781(94)90017-5;
RA   Feng J.Q., Harris M.A., Ghosh-Choudhury N., Feng M., Mundy G.R.,
RA   Harris S.E.;
RT   "Structure and sequence of mouse bone morphogenetic protein-2 gene
RT   (BMP-2): comparison of the structures and promoter regions of BMP-2
RT   and BMP-4 genes.";
RL   Biochim. Biophys. Acta 1218:221-224(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-351.
RX   MEDLINE=90228966; PubMed=1970330; DOI=10.1016/0888-7543(90)90480-I;
RA   Dickinson M.E., Kobrin M.S., Silan C.M., Kingsley D.M., Justice M.J.,
RA   Miller D.A., Ceci J.D., Lock L.F., Lee A., Buchberg A.M.,
RA   Siracusa L.D., Lyons K.M., Derynck R., Hogan B.L.M., Copeland N.G.,
RA   Jenkins N.A.;
RT   "Chromosomal localization of seven members of the murine TGF-beta
RT   superfamily suggests close linkage to several morphogenetic mutant
RT   loci.";
RL   Genomics 6:505-520(1990).
RN   [3]
RP   INTERACTION WITH SOSTDC1.
RX   MEDLINE=22984999; PubMed=14623234; DOI=10.1016/j.ydbio.2003.08.011;
RA   Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.;
RT   "Identification of a secreted BMP antagonist, ectodin, integrating
RT   BMP, FGF, and SHH signals from the tooth enamel knot.";
RL   Dev. Biol. 264:91-105(2003).
RN   [4]
RP   INTERACTION WITH GREM2.
RX   PubMed=15039429; DOI=10.1074/jbc.M402376200;
RA   Sudo S., Avsian-Kretchmer O., Wang L.S., Hsueh A.J.;
RT   "Protein related to DAN and cerberus is a bone morphogenetic protein
RT   antagonist that participates in ovarian paracrine regulation.";
RL   J. Biol. Chem. 279:23134-23141(2004).
RN   [5]
RP   INTERACTION WITH RGMB.
RX   PubMed=15671031; DOI=10.1074/jbc.M410034200;
RA   Samad T.A., Rebbapragada A., Bell E., Zhang Y., Sidis Y., Jeong S.-J.,
RA   Campagna J.A., Perusini S., Fabrizio D.A., Schneyer A.L., Lin H.Y.,
RA   Brivanlou A.H., Attisano L., Woolf C.J.;
RT   "DRAGON, a bone morphogenetic protein co-receptor.";
RL   J. Biol. Chem. 280:14122-14129(2005).
RN   [6]
RP   INTERACTION WITH RGMA.
RX   PubMed=15975920; DOI=10.1074/jbc.M503511200;
RA   Babitt J.L., Zhang Y., Samad T.A., Xia Y., Tang J., Campagna J.A.,
RA   Schneyer A.L., Woolf C.J., Lin H.Y.;
RT   "Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone
RT   morphogenetic protein co-receptor.";
RL   J. Biol. Chem. 280:29820-29827(2005).
RN   [7]
RP   INTERACTION WITH RGMC.
RX   PubMed=16604073; DOI=10.1038/ng1777;
RA   Babitt J.L., Huang F.W., Wrighting D.M., Xia Y., Sidis Y., Samad T.A.,
RA   Campagna J.A., Chung R.T., Schneyer A.L., Woolf C.J., Andrews N.C.,
RA   Lin H.Y.;
RT   "Bone morphogenetic protein signaling by hemojuvelin regulates
RT   hepcidin expression.";
RL   Nat. Genet. 38:531-539(2006).
RN   [8]
RP   INTERACTION WITH RGMA.
RX   PubMed=17472960; DOI=10.1074/jbc.M701679200;
RA   Xia Y., Yu P.B., Sidis Y., Beppu H., Bloch K.D., Schneyer A.L.,
RA   Lin H.Y.;
RT   "Repulsive guidance molecule RGMa alters utilization of bone
RT   morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.";
RL   J. Biol. Chem. 282:18129-18140(2007).
CC   -!- FUNCTION: Induces cartilage and bone formation.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with SOSTDC1,
CC       GREM2, RGMA, RGMB and RGMC.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
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DR   EMBL; L25602; AAB05665.1; -; Genomic_DNA.
DR   IPI; IPI00121379; -.
DR   PIR; A34201; A34201.
DR   PIR; S45355; S45355.
DR   UniGene; Mm.103205; -.
DR   SMR; P21274; 289-394.
DR   STRING; P21274; -.
DR   PRIDE; P21274; -.
DR   Ensembl; ENSMUST00000028836; ENSMUSP00000028836; ENSMUSG00000027358; Mus musculus.
DR   MGI; MGI:88177; Bmp2.
DR   HOGENOM; P21274; -.
DR   HOVERGEN; P21274; -.
DR   ArrayExpress; P21274; -.
DR   Bgee; P21274; -.
DR   CleanEx; MM_BMP2; -.
DR   Genevestigator; P21274; -.
DR   GermOnline; ENSMUSG00000027358; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; TAS:MGI.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004745; F:retinol dehydrogenase activity; IDA:MGI.
DR   GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
DR   GO; GO:0030282; P:bone mineralization; IDA:MGI.
DR   GO; GO:0001658; P:branching involved in ureteric bud morphoge...; IGI:MGI.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0045165; P:cell fate commitment; IMP:MGI.
DR   GO; GO:0009790; P:embryonic development; IMP:MGI.
DR   GO; GO:0040007; P:growth; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEP:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
DR   GO; GO:0042475; P:odontogenesis of dentine-containing tooth; IDA:MGI.
DR   GO; GO:0001649; P:osteoblast differentiation; IGI:MGI.
DR   GO; GO:0048711; P:positive regulation of astrocyte differenti...; IDA:MGI.
DR   GO; GO:0010552; P:positive regulation of gene-specific transc...; IDA:MGI.
DR   GO; GO:0045669; P:positive regulation of osteoblast different...; IDA:MGI.
DR   GO; GO:0007179; P:transforming growth factor beta receptor si...; TAS:MGI.
DR   InterPro; IPR001839; TGFb.
DR   InterPro; IPR017948; TGFb_CS.
DR   InterPro; IPR001111; TGFb_N.
DR   InterPro; IPR015615; TGFbeta.
DR   PANTHER; PTHR11848; TGFbeta; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Chondrogenesis; Cleavage on pair of basic residues; Cytokine;
KW   Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW   Growth factor; Osteogenesis; Secreted; Signal.
FT   SIGNAL        1     19       Potential.
FT   PROPEP       20    280
FT                                /FTId=PRO_0000033826.
FT   CHAIN       281    394       Bone morphogenetic protein 2.
FT                                /FTId=PRO_0000033827.
FT   CARBOHYD    134    134       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    162    162       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    198    198       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    336    336       N-linked (GlcNAc...) (Potential).
FT   DISULFID    294    359       By similarity.
FT   DISULFID    323    391       By similarity.
FT   DISULFID    327    393       By similarity.
FT   DISULFID    358    358       Interchain (By similarity).
FT   CONFLICT    110    110       T -> S (in Ref. 2).
FT   CONFLICT    113    114       QL -> HE (in Ref. 2).
FT   CONFLICT    271    271       G -> R (in Ref. 2).
SQ   SEQUENCE   394 AA;  44514 MW;  FD6A0F10587EED54 CRC64;
     MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAAASSRP LSRPSEDVLS EFELRLLSMF
     GLKQRPTPSK DVVVPPYMLD LYRRHSGQPG APAPDHRLER AASRANTVRT FHQLEAVEEL
     PEMSGKTARR FFFNLSSVPS DEFLTSAELQ IFREQIQEAL GNSSFQHRIN IYEIIKPAAA
     NLKFPVTRLL DTRLVNQNTS QWESFDVTPA VMRWTTQGHT NHGFVVEVAH LEENPGVSKR
     HVRISRSLHQ DEHSWSQIRP LLVTFGHDGK GHPLHKREKR QAKHKQRKRL KSSCKRHPLY
     VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV
     PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR
//