ID SCG1_MOUSE Reviewed; 677 AA. AC P16014; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1991, sequence version 2. DT 24-NOV-2009, entry version 86. DE RecName: Full=Secretogranin-1; DE AltName: Full=Secretogranin I; DE Short=SgI; DE AltName: Full=Chromogranin-B; DE Short=CgB; DE Flags: Precursor; GN Name=Chgb; Synonyms=Scg-1, Scg1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Pituitary; RX MEDLINE=90206804; PubMed=2320426; DOI=10.1093/nar/18.5.1298; RA Linard C.G., Mbikay M., Seidah N.G., Chretien M.; RT "Primary structure of mouse chromogranin B deduced from cDNA RT sequence."; RL Nucleic Acids Res. 18:1298-1298(1990). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=90242932; PubMed=2335203; DOI=10.1016/0014-5793(90)80194-N; RA Pohl T.M., Phillips E., Song K., Gerdes H.-H., Huttner W.B., RA Ruether U.; RT "The organisation of the mouse chromogranin B (secretogranin I) RT gene."; RL FEBS Lett. 262:219-224(1990). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-151, AND MASS SPECTROMETRY. RC TISSUE=Liver; RX PubMed=16916647; DOI=10.1016/j.molcel.2006.06.026; RA Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., RA Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; RT "Substrate and functional diversity of lysine acetylation revealed by RT a proteomics survey."; RL Mol. Cell 23:607-618(2006). CC -!- FUNCTION: Secretogranin-1 is a neuroendocrine secretory granule CC protein, which may be the precursor for other biologically active CC peptides. CC -!- INTERACTION: CC P00441:SOD1 (xeno); NbExp=2; IntAct=EBI-990820, EBI-990792; CC -!- SUBCELLULAR LOCATION: Secreted. Note=Neuroendocrine and endocrine CC secretory granules. CC -!- SIMILARITY: Belongs to the chromogranin/secretogranin protein CC family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X53028; CAA37199.1; -; mRNA. DR EMBL; X51429; CAA35792.1; -; mRNA. DR EMBL; BC014736; AAH14736.1; -; mRNA. DR IPI; IPI00130307; -. DR PIR; S09078; S09078. DR RefSeq; NP_031720.1; -. DR UniGene; Mm.255241; -. DR IntAct; P16014; 2. DR STRING; P16014; -. DR PhosphoSite; P16014; -. DR PRIDE; P16014; -. DR Ensembl; ENSMUST00000028826; ENSMUSP00000028826; ENSMUSG00000027350; Mus musculus. DR GeneID; 12653; -. DR KEGG; mmu:12653; -. DR UCSC; uc008mnf.1; mouse. DR CTD; 12653; -. DR MGI; MGI:88395; Chgb. DR HOGENOM; P16014; -. DR HOVERGEN; P16014; -. DR OMA; NWGYEKR; -. DR OrthoDB; EOG970X32; -. DR NextBio; 281868; -. DR PMAP-CutDB; P16014; -. DR ArrayExpress; P16014; -. DR Bgee; P16014; -. DR CleanEx; MM_CHGB; -. DR Genevestigator; P16014; -. DR GermOnline; ENSMUSG00000027350; Mus musculus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR InterPro; IPR001819; Chromogranin_AB. DR InterPro; IPR018054; Chromogranin_CS. DR InterPro; IPR001990; Granin. DR PANTHER; PTHR10583; Chromogranin_AB; 1. DR Pfam; PF01271; Granin; 1. DR PRINTS; PR00659; CHROMOGRANIN. DR PROSITE; PS00422; GRANINS_1; 1. DR PROSITE; PS00423; GRANINS_2; 1. PE 1: Evidence at protein level; KW Acetylation; Cleavage on pair of basic residues; Disulfide bond; KW Glycoprotein; Phosphoprotein; Secreted; Signal; Sulfation. FT SIGNAL 1 20 FT CHAIN 21 677 Secretogranin-1. FT /FTId=PRO_0000005441. FT MOD_RES 99 99 Phosphoserine (Potential). FT MOD_RES 100 100 Phosphoserine (Potential). FT MOD_RES 151 151 N6-acetyllysine. FT MOD_RES 171 171 Sulfotyrosine (Potential). FT MOD_RES 256 256 Phosphoserine (By similarity). FT MOD_RES 260 260 Phosphoserine (By similarity). FT MOD_RES 300 300 Phosphoserine (Potential). FT MOD_RES 301 301 Phosphoserine (Potential). FT MOD_RES 318 318 Phosphoserine (By similarity). FT MOD_RES 342 342 Phosphoserine (By similarity). FT MOD_RES 348 348 Sulfotyrosine (By similarity). FT MOD_RES 375 375 Phosphoserine (By similarity). FT MOD_RES 378 378 Phosphoserine (By similarity). FT MOD_RES 469 469 Sulfotyrosine (Potential). FT MOD_RES 472 472 Sulfotyrosine (Probable). FT MOD_RES 532 532 Phosphoserine (Potential). FT MOD_RES 543 543 Phosphoserine (Potential). FT MOD_RES 566 566 Sulfotyrosine (Probable). FT MOD_RES 568 568 Sulfotyrosine (Potential). FT MOD_RES 626 626 Phosphoserine (By similarity). FT CARBOHYD 115 115 O-linked (GalNAc...) (Probable). FT DISULFID 36 57 By similarity. FT CONFLICT 422 424 REP -> LGA (in Ref. 1; CAA35792). SQ SEQUENCE 677 AA; 77969 MW; C73291E781E4F9B9 CRC64; MQPAMLLGLL GAAALAAVSS APVDNRDHNE EMVTRCIIEV LSNALSKSSV PTITPECRQV LKKSGKEVKG EEKGENQNSK FEVRLLRDPA DASGTRWASS REDAGAPVED SQGQTKVGNE KWTEGGGHSR EGVDDQESLR PSNQQASKEA KIYHSEERVG KEREKEEGKI YPMGEHREDA GEEKKHIEDS GEKPNTFSNK RSEASAKKKD ESVARADAHS MELEEKTHSR EQSSQESGEE TRRQEKPQEL TDQDQSQEES QEGEEGEEGE EGEEGEEDSA SEVTKRRPRH HHGRSGSNKS SYEGHPLSEE RRPSPKESKE ADVATVRLGE KRSHHLAHYR ASEEEPEYGE ESRSYRGLQY RGRGSEEDRA PRPRSEESQE REYKRNHPDS ELESTANRHG EETEEERSYE GANGRQHRGR GREPGAHSAL DTREEKRLLD EGHYPVRESP IDTAKRYPQS KWQEQEKNYL NYGEEGDQGR WWQQEEQLGP EESREEVRFP DRQYEPYPIT EKRKRLGALF NPYFDPLQWK NSDFEKRGNP DDSFLEDEGE DRNGVTLTEK NSFPEYNYDW WERRPFSEDV NWGYEKRSFA RAPQLDLKRQ YDGVAELDQL LHYRKKADEF PDFYDSEEQM GPHQEANDEK ARADQRVLTA EEKKELENLA AMDLELQKIA EKFSQRG //