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EBI DbfetchID Z47210; SV 1; linear; genomic DNA; STD; PRO; 14056 BP. XX AC Z47210; XX DT 01-MAR-1995 (Rel. 42, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 12) XX DE S.pneumoniae dexB, cap3A, cap3B and cap3C genes and orfs XX KW alpha,1-6-glucosidase; cap3A gene; cap3B gene; cap3C gene; KW cellubiuronic acid synthase; dexB gene; KW glucosephosphate uridylyltransferase; KW uridine diphosphate glucose dehydrogenase. XX OS Streptococcus pneumoniae OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus. XX RN [1] RP 1-14056 RA Garcia E., Arrecubieta C., Munoz R., Mollerach M., Lopez R.; RT "A functional analysis of the Streptococcus pneumoniae genes involved in RT the synthesis of type 1 and type 3 capsular polysaccharides"; RL Unpublished. XX RN [2] RP 1-9704 RX DOI; 10.1016/0378-1119(95)00657-5 RX PUBMED; 8566758. RA Arrecubieta C., Garcia E., Lopez R.; RT "Sequence and transcriptional analysis of a DNA region involved in the RT production of capsular polysaccharide in Streptococcus pneumoniae type 3"; RL Gene 167(1-2):1-7(1995). XX RN [3] RP 5911-7095 RX PUBMED; 7929009. RA Arrecubieta C., Lopez R., Garcia E.; RT "Molecular characterization of cap3A, a gene from the operon required for RT the synthesis of the capsule of Streptococcus pneumoniae type 3: sequencing RT of mutations responsible for the unencapsulated phenotype and localization RT of the capsular cluster on the pneumococcal chromosome"; RL J. Bacteriol. 176(20):6375-6383(1994). XX RN [4] RC Revised by [5] RA Garcia E.; RT ; RL Submitted (04-JAN-1995) to the EMBL/GenBank/DDBJ databases. RL Garcia E., Centro de Investigaciones Biologicas. CSIC., Microbiologia RL Molecular, Velazquez, 144, Madrid, Madrid, SPAIN, 28006 XX RN [5] RP 1-14056 RA Garcia E.; RT ; RL Submitted (11-SEP-1996) to the EMBL/GenBank/DDBJ databases. RL Garcia E., Centro de Investigaciones Biologicas. CSIC., Microbiologia RL Molecular, Velazquez, 144, Madrid, Madrid, SPAIN, 28006 XX FH Key Location/Qualifiers FH FT source 1..14056 FT /organism="Streptococcus pneumoniae" FT /strain="406" FT /mol_type="genomic DNA" FT /db_xref="taxon:1313" FT CDS <1..697 FT /codon_start=2 FT /transl_table=11 FT /gene="dexB" FT /standard_name="glucosidase" FT /product="alpha, 1-6-glucosidase" FT /function="degradation of glucans" FT /db_xref="GOA:Q54796" FT /db_xref="HSSP:1UOK" FT /db_xref="InterPro:IPR006047" FT /db_xref="UniProtKB/Swiss-Prot:Q54796" FT /citation=[1] FT /citation=[2] FT /protein_id="CAA87400.1" FT /translation="NSLFWNNHDLPRIVSIWGNDQEYREKSAKAFAILLHLMRGTPYIY FT QGEEIGMTNYPFETLDQVEDIESLNYPREALEKGVPIEEIMDSIRVIGRDNARTPMQWD FT ESKNAGFSTGQPWLAVNPNYEMINVQEALANPDSIFYTYQKLVQIRKENSWLIRADFEL FT LDTADKVFAYIRKDGDRRFLVVANLSNEEQDLTVEGKVKSVLIENTLAQEVFEKQILVP FT WDAFCVELL" FT terminator 1042..1087 FT /citation=[1] FT /citation=[2] FT RBS 3639..3643 FT /citation=[2] FT CDS 3649..4341 FT /transl_table=11 FT /gene="orf1" FT /product="unknown" FT /note="The deduced amino acid sequence contains a sugar FT transport signature (LIGFLAGGIGTSVIVLLLELLDTHVK) typical of FT glucose transporters" FT /db_xref="GOA:Q4K355" FT /db_xref="InterPro:IPR005829" FT /db_xref="UniProtKB/TrEMBL:Q4K355" FT /citation=[1] FT /citation=[2] FT /protein_id="CAA87401.1" FT /translation="MKEQNTLEIDVLQLFRALWKRKLVILLVAIITSSVAFAYSTFVIK FT PEFTSTTRIYVVNRNQGEKSGLTNQDLQAGSYLVKDYREIILSQDVLEEVISDLKLDLT FT PKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVATLE FT EARPAISPSSPNIKRNTLIGFLAGGIGTSVIVLLLELLDTHVKRPEDIEDTLQMTLLGV FT VPNLGKLK" FT RBS 4340..4344 FT /citation=[2] FT CDS 4351..4815 FT /transl_table=11 FT /gene="orf2" FT /product="unknown" FT /db_xref="GOA:Q54798" FT /db_xref="InterPro:IPR005702" FT /db_xref="UniProtKB/TrEMBL:Q54798" FT /citation=[1] FT /citation=[2] FT /protein_id="CAA87402.1" FT /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVNP FT GEGKTTTSVNIARSFARAGYKTLLIDGDTRNSVMSGFFKSREKITELTEFLSGTADLSH FT GLCDTNIENLFVVQSGSVSPNPTALLQSKNFVVMVKIFSKEVSILSWWKR" FT terminator 4851..4903 FT /citation=[1] FT /citation=[2] FT -35_signal 5819..5824 FT /gene="cap3A" FT /citation=[1] FT /citation=[2] FT /citation=[3] FT /experiment="experimental evidence, no additional details FT recorded" FT -10_signal 5841..5846 FT /gene="cap3A" FT /citation=[1] FT /citation=[2] FT /citation=[3] FT /experiment="experimental evidence, no additional details FT recorded" FT mRNA 5853..>7095 FT /gene="cap3A" FT /citation=[1] FT /citation=[2] FT /experiment="experimental evidence, no additional details FT recorded" FT RBS 5893..5900 FT /gene="cap3A" FT /citation=[2] FT CDS 5911..7095 FT /transl_table=11 FT /gene="cap3A" FT /standard_name="UDP-Glc dehydrogenase" FT /product="uridine diphosphate glucose dehydrogenase" FT /function="synthesis of UDP-glucuronic acid from FT UDP-glucose" FT /note="The Cap3A protein has been biochemically FT characterized, J. Bacteriol. 178:2971-2974(1996)" FT /db_xref="GOA:Q57346" FT /db_xref="HSSP:1DLJ" FT /db_xref="InterPro:IPR001732" FT /db_xref="UniProtKB/Swiss-Prot:Q57346" FT /citation=[1] FT /citation=[2] FT /citation=[3] FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA87403.1" FT /translation="MKIAIAGSGYVGLSLAVLLAQHHEVKVIDVIKDKVESINNRKSPI FT KDEAIEKYLVEKELNLEASLDPAHVYKDVEYAIIATPTNYDVDLNQFDTSSVEAAIKTC FT MEYNDTCTIVIKSTIPEGYTKEVREKFNTDRIIFSPEFLRESKALYDNLYPSRIVVGTD FT LDDSELTKRAWQFADLLKGGAIKEEVPILVVAFNEAEVAKLFSNTYLATRVRYFNEIDT FT YSEVKGLNPKTIIDIVCYDPRIGSYYNNPSFGYGGYCLPKDTKQLKASFRDVPENLITA FT VVQSNKTRKDYIAGAILAKQPSVVGIYRLIMKSDSDNFRSSAVKGVMERLDNYGKEIVI FT YEPTIECDTFMGYRVIKSLDEFKNISDIVVANRMNDDLRDIQEKLYTRDLFGRE" FT RBS 7094..7099 FT /gene="cap3B" FT /citation=[2] FT CDS 7111..8364 FT /transl_table=11 FT /gene="cap3B" FT /product="Synthase of the type 3 pneumococcal capsular FT polysaccharide" FT /function="Synthesis of type 3 pneumococcal capsule" FT /note="Expression and characterization of this gene has FT been recently reported, J. Exp. Med. 184:449-455(1996)" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:P72520" FT /citation=[1] FT /citation=[2] FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA87404.1" FT /translation="MYTFILMLLDFFQNHDFHFFMLFFVFILIRWAVIYFHAVRYKSYS FT CSVSDEKLFSSVIIPVVDEPLNLFESVLNRISRHKPSEIIVVINGPKNERLVKLCHDFN FT EKLENNMTPIQCYYTPVPGKRNAILFGLEHVDSQSDITVLVDSDTVWTPRTLSELLKPF FT VCDKKIGGVTTRQKILDPERNLVTMFANLLEEIRAEGTMKAMSVTGKVGCLPGRTIAFR FT TEILRECIHEFMNETFMGFHKEVSDDRSLTNLTLKKGYKTVMQDTSVVYTDAPTSWKKF FT IRQQLRWAEGSQYNNLKMTPWMIRNAPLMFFIYFTDMILPMLLISFGVNIFLLKILNIT FT TIVYTASWWEIILYVLLGMIFSFGGRNFKAMSRMKWYYVFLIPVFIIVLSIIMCPIRLL FT GLMRCSDDLGWGTRNLTE" FT RBS 8651..8654 FT /gene="cap3C" FT /citation=[2] FT CDS 8662..9582 FT /transl_table=11 FT /gene="cap3C" FT /standard_name="UDP-glucose pyrophosphorylase" FT /product="glucosephosphate uridylyltransferase" FT /function="synthesis of UDP-glucose" FT /db_xref="GOA:Q54800" FT /db_xref="InterPro:IPR005835" FT /db_xref="UniProtKB/Swiss-Prot:Q54800" FT /citation=[1] FT /citation=[2] FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA87405.1" FT /translation="MKKVKKAVIPAAGLGTRFLPATKALAKEMLPIVDRPTIHFVIEEA FT LRSGIEDILVVTGKSKRSIEDYFDSTFELEYSLRKQGKMELLKSVNESTDIKVHFVRQS FT SPRGLGDAVLQAKSFVGDDPFVVMLGDDLMDITDSTAVPLTRQLMDDYNATQASTIAVM FT PVRYEDVSSYGVISPRLESSNGLYSVDAFVEKPKPEEAPSNLAIIGRYLLTPEIFSILE FT TQKPGAGNEIQLTDAIDTLNKTQSVFAREFVGKRYDVGDKFNFMKTSIDYALQHPQIKE FT SLKNYVIALGKQLEKLDDCSSSGHL" FT RBS 9568..9573 FT /citation=[1] FT CDS 9579..10796 FT /transl_table=11 FT /gene="orf3" FT /product="unknown" FT /note="This reading frame is extended at its 3' end by a FT fragment of an insertion sequence. The predicted FT polypeptide contains a phosphosglucomutase and FT phosphomannomutase phosphoserine signature." FT /db_xref="GOA:P72521" FT /db_xref="InterPro:IPR016055" FT /db_xref="UniProtKB/TrEMBL:P72521" FT /citation=[1] FT /protein_id="CAA87406.1" FT /translation="MNCIESYQKWLNVPDLPAYLKDELLSMDDKTKEDAFYTNLEFGTA FT GMRGYIGAGTNRINIYVVRQATEGLAKLVESKGETAKKAGVAIAYDSRHFSPEFAFESA FT QVLAAHGIKSYVFESLRPTPELSFAVRHLGAFAGIMVTASHTPAPFNGYKVYGSDGGQM FT LPADADALTDYIRAIDNPFAVVLADLEEAKSTGLIEVIGETLDAAYLEEVKSVNINEDL FT IDQYGRDMQIVYTPLHGTGEMLARRALAQAGFESVQVVEAQAKPDPDFSTVASPNPESQ FT AAFALAEELGRQVDADVLVATDPDADRLGVEIRQADGSYWNLSGNQIGALIAKYILEAH FT KQAGTLPKNAALAKSIVSTELVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYM FT FGFEES" FT repeat_region complement(10650..11271) FT /mobile_element="insertion sequence:IS1167-like" FT /note="55% of the nucleotides are identical to those FT located in a fragment of the insertion sequence IS1167" FT misc_feature 11274..12457 FT /gene="plpA" FT /note="This region is 98% identical to the plpA gene of S. FT pneumoniae. However, the 5' end of the gene is missing and FT two additional nucleotides have been found at positions FT 11337 (T) and 11780 (G)." FT /citation=[1] FT RBS 12655..12659 FT /citation=[1] FT CDS 12671..13792 FT /transl_table=11 FT /gene="orf" FT /db_xref="GOA:P72522" FT /db_xref="InterPro:IPR005877" FT /db_xref="UniProtKB/TrEMBL:P72522" FT /protein_id="CAA87407.1" FT /translation="MNKGLFEKRCKYSIRKFSLGVASVMIGAAFFGTSPVLADSVQSGS FT TANLPADLATALATAKENDGRDFEAPKVGEDQGSPEVTDGPKTEEELLALEKEKPAEEK FT PKEDKPAAAKPETPKTVTPEWQTVEKKEQQGTVTIREEKGVRYNQLSSTAQNDNAGKPA FT LFEKKGLTVDANGNATVDLTFKDDSEKGKSRFGVFLKFKDTKNNVFVGYDKDGWFWEYK FT SPTTSTWYRGSRVAAPETGSTNRLSITLKSDGQLNASNNDVNLFDTVTLPAAVNDHLKN FT EKKILLKAGSYDDERTVVSVKTDNQEGVKTEDTPAEKETGPEVDDSKVTYDTIQSKVLK FT AVIDQAFPSCQGIQLEWTYFARTGSTVQPSLYQ" FT sig_peptide 12671..12784 FT /note="similar to the signal peptide of the NanA FT pneumococcal neuraminidase" FT /citation=[1] FT mat_peptide 12785..13789 FT /product="unknown" FT /citation=[1] FT misc_feature 1658..1689 FT /function="recognition sequence for the insertion sequence FT IS1202" FT /citation=[2] XX SQ Sequence 14056 BP; 4540 A; 2313 C; 2936 G; 4267 T; 0 other; gaattccctc ttctggaaca accatgacct ccctcgtatt gtctcaatct ggggaaatga 60 ccaagaatac cgcgaaaaat ctgccaaagc ctttgcaatc ttacttcatc tcatgagagg 120 aactccttat atctaccaag gtgaggagat tgggatgacc aactatccgt ttgaaactct 180 ggatcaagta gaagatattg aatctctcaa ctatccccgt gaggctcttg aaaaaggtgt 240 tccgattgaa gaaatcatgg acagtatccg tgttattgga cgtgacaatg cccgtacccc 300 tatgcaatgg gacgagagca aaaacgctgg tttctcaaca ggtcaacctt ggttggcggt 360 taatccaaat tacgagatga tcaacgtaca agaagcgctg gcaaatccag attctatttt 420 ctatacctat cagaaactgg tccaaattcg caaggagaat agctggctaa ttcgagctga 480 ctttgaattg cttgatacgg ctgataaggt ctttgcttat atacgtaagg atggcgaccg 540 tcgcttccta gttgtggcta acttgtccaa tgaagagcaa gacttgacag tagaaggaaa 600 agtcaaatct gtcttgattg aaaacaccct agctcaagaa gtctttgaaa aacaaatctt 660 agttccatgg gatgctttct gtgtggaatt actataaata tttttgcaga aaaatttaaa 720 attgaaatca tataaaaaca agggaggact gtataaaaag cagaaatcct ttgtttttta 780 taaccaaggt ttataaactt tcattctcga aattcaatta actttacaaa ttcccactat 840 taaggagaaa gaagatgaac ataaagaagc gtgtccttag tgcaggcctg acttttgcat 900 ctgctttgct tttagctgct tgcggccaat caggttcaga tacaaaaact tactcatcaa 960 cctttagtgg aaatccaact acatttaact atctattaga ctattaccct gataatatag 1020 tcaattgaaa caagaacagg acaaaagagc ctcgtaaaag gtattgcaac ttggtaatac 1080 ctttttgagg tgctttttga tatgagccca tgttttctca ataggattgt actcaggtga 1140 gtagaaagga agaggtaaaa gtttataccc aaactcttca cacaagagtt ctagcttccc 1200 cattctatgg aatcttgcat tatccataat aataaccgat ggtgtggtta atgttggtaa 1260 gaaaaacttc tgaaaccata cttcaaaaaa gtcgctcgtc atcgtctctt cgtaagtcat 1320 tggagcgatt aattcaccat ttgttagacc tgcaaccaaa gaaattctct gatatcttct 1380 tcttaactga ccttttaaag agcgaccata ttctcgataa aaataagtat caaatcctgt 1440 ttcgtcaatc taaacaggta ctaggtgctt taaactatta aaattcttaa gaaataaggc 1500 tactttttct gggtcttgtt cataattaga ttgaaactag aatagtagac ctctgcttct 1560 aaaacattgt tagaaatcga tttgactgtc ctgatcgatt tgtcatgttc ttatttcatt 1620 ttactatatt tttggttcgc gggaagtcta ctaagatact taaagataca gatagtgaaa 1680 ataaaggtgt agacattacc gttggtgttc tctatccttg tcagctctgt gtcgctcttt 1740 gcagtacagc agtttgttgg actgaccaat cgtttaaatg cgacttctaa ttactcagga 1800 tattcgatca gtgtcgctgt tttagcagat agtgagatcg aaaatgttac gcaactgacg 1860 agtgtgacag caccgactgg gactgataat gaaaatattc aaaaattact agctgatatc 1920 aagtcagaat accgatttga cggtcgacca gagttcgtct tacttggctg cttacaagag 1980 tctgattgca ggtgacacca agaccattgt cctaaatagt gtctttgaaa atatcatcga 2040 gtcagagtat ccagactacg catcgaagat aaaaaatatt tataccaagg gatttactaa 2100 aaaagtagaa gctcctaaga cgtctaagaa tcagtctttc aatatctaag ttagtggaat 2160 tgacacctat ggtcctatta gttcggtgtc gcgatcagat gtcaatatcc tgatgactgt 2220 caatcgagat accaagaaaa tcctcttgac cacaacgccg cgtgatgcct atgtaccaat 2280 tgcagatggt ggaaataatc aaaaagataa attgactcat gcgggcattt atggagttga 2340 ttcgtccatt cacaccttag aaaatctcta tggagtggat atcaattact atgtacgatt 2400 gaacttcact tcgtttttga aattgattga tttgttggat ggaattgatg tttataatga 2460 tcaagaattt actgcccata cgaatggaaa gtattaccct gaaggcaatg ttcatcttga 2520 ttcagaacag gctctcggtt ttgttcgtga gcgctactcc ctagcagatg gcgatcgtga 2580 ccgcgggcgc aatcaacaaa aggtgattgt ggctatcctt caaaaattaa cgtcaaccga 2640 agaactgaaa aattatagta cgatcattga tagcttgcaa gattctatcc aaacaaatat 2700 gccacttgag actatgatag atttagtgaa tactcagttg gaaagtggag ggaattataa 2760 agtaaattct caagatttaa aagggacagg tcggatggat cttccttctt atgcaatgcc 2820 agacagtaac ctctatgtga tggaaataga tgatagtagt ttagctgtag ttaaagcagc 2880 tatacaggat gtgatgaaag gtagatgaaa tgatagacat ccattcgcat atcgtttttg 2940 atgtagatga tggtcccaag tcaatagagg atagcaaggc acttttaaga gaagcttata 3000 atcaaggagt tcgaatgatt gtgtctactt cgcatcgtcg aaaagggatg tttgaaactc 3060 cagaagaaaa aattgtaaca aattttatta aggttcgtga aattgcaaaa gaagtagcag 3120 atgatttagt cattgcttat ggcgcagaga tatactatac tctggatgct ctagaaaagc 3180 tagaaaaaaa gaaattccta cccttaatga tagtcgttat gctttgattg agtttagcat 3240 gcatacttcc tatcgtgaga ttcatacgag attgagcaat attttgatgt tgggaatcac 3300 gccagtaatt gctcatattg aacgttatga tgctttagag aataacgaaa aacgtgttcg 3360 tgaactgatt gatatggggt gctatactca gatagatagt tatcatgttt caaaacctaa 3420 gttctttggt gaaaaatata aattcatgaa aaagagagct cggtattttt tggaacgtga 3480 tttagttcat gtagttgcaa gtgacatgca caatttagac agtagacctc catatatgca 3540 acaggcatat gatatcattg ctaagaaata tagagcgaaa aaagcgaaag aactttttgt 3600 agataatccc agaaaaatta taatggatca attaatttag gagaaaatat gaaggaacaa 3660 aacactttgg aaatcgatgt attgcaacta ttcagagctt tatggaaaag aaagttggtc 3720 attttattag tggcaattat aacttcttca gttgcttttg cctacagtac ttttgttatc 3780 aaacctgagt ttactagtac gactcggatt tatgtagtta accgtaatca gggagagaag 3840 tctggtttaa ccaatcaaga cttgcaggca ggatcatact tggttaaaga ctatcgtgaa 3900 attatcctat cgcaggatgt tttggaggaa gttatttctg atttgaaact agatttgacg 3960 ccaaaaggtt tggctaataa aattaaagta acagtaccag ttgatacccg tattgtctct 4020 gtttcagtta atgatcgagt tcctgaagag gcaagccgta tcgctaactc tttgagagaa 4080 gtagctgctc aaaaaattat cagtattact cgtgtttctg atgtggcaac actggaggag 4140 gcaagaccgg cgatatcacc gtcttcgcca aatattaaac gcaatacact aattggtttt 4200 ttggcagggg ggattggaac tagtgttata gttcttcttc ttgaactttt ggacactcat 4260 gtgaaacgtc cggaagatat cgaagataca ctgcagatga cacttttggg agttgtacca 4320 aacttgggta agttgaaata ggagagagga atgccgacat tagaaatagc acaaaaaaaa 4380 ctggagttca ttaagaaggc agaagaatat tacaatgcct tgtgtacaaa tatacagttg 4440 agcggagata aactaaaagt aatttccgtt acttctgtta accctgggga aggaaaaaca 4500 actacttccg taaatatagc aaggtcgttt gcgcgtgcag gctataaaac tcttttgatc 4560 gatggtgata ctcgaaattc agttatgtca ggatttttta aatctcgtga aaaaattaca 4620 gagctaacag aatttttatc tgggacagct gatttatctc acggtttatg tgatacaaat 4680 attgaaaatt tatttgtagt tcaatcggga tctgtatcac caaaccctac agccttgtta 4740 caaagtaaaa attttgtggt tatggtaaag attttttcaa aagaggtcag tatattgagt 4800 tggtggaaac gataaaatac ataatatttt attcctttgg ttatcaaatt agcccctcct 4860 gaagctcccc aattgacggc ttgagctcca atcaaagggt gtttgtccgc tttttgacag 4920 agggtaatcg ctagaggaca gcaaacggcc atagtagtga aaaatccagc acctaaagca 4980 gacaaaaggg ttgccatcag gtataaaatc atgtagaggg cgttagggta ggtgcgtgtg 5040 cggtagagaa tgtgttgagc caaaacatca agagtaccgt tagttattgc aaagttataa 5100 aagagagaga cgctaaaaat ggtaaaaaag agtgaggttg gccaaaaatg aagaagttct 5160 ttggggctta atcccatgag agtggttgcg atgaggtaag aaaaagcaat agccagcagg 5220 tcaatattga ttttggtgcg gtaaccaatt ccaatggcta gagcaatggc gctaatcatt 5280 attaaatgaa tcattgaatt gtcctttagt tagaatatag aaagaggata gattgaagtt 5340 cgagaatact gggtgtcttc tgatgttaag tggttgtgtc aaaaccatcc caaatggcat 5400 aaattgcgtg gaattggaat gactcgtaat actattgata gagatggtat tacaagtcaa 5460 gacgttcgct attttatctt taactttaag cttgatgtga tgacctttgc catagtgttc 5520 gaggtcattg gtcagcagaa agtatgcatt ggttattgga tgtggtttat cgtgaagacc 5580 atcatcagac cctggataaa cgagctgctt ttaaccttaa tcttatccga aaaatgtgtt 5640 tatattttct aaaagtgatg gtattttcta aaaaagacct cagctatcga tgcaaacaac 5700 ggtatatctc tgtccatttg gaagattatt tggaaacaga ggttaggaaa gtaatcagtt 5760 taacgggata tcttttcaaa gctgatacta aggcacaaaa aaaagtttga tattcccctt 5820 gacaatagat aaaattatta tataattaaa ctattgcttt ttaaataaag tgagaatatt 5880 aataatgcag agaaagagga ctgtagtaaa atgaaaattg ccattgcagg aagtggttat 5940 gtaggactgt ctttagcggt gctactagct cagcatcatg aagttaaggt cattgatgtt 6000 ataaaggata aggtagagtc gataaacaat agaaaatctc caattaagga tgaggcgatt 6060 gagaaatact tagttgaaaa agagttgaat cttgaagcct ccttagatcc tgcacacgtt 6120 tataaagacg tggagtatgc tattattgct actccgacta attatgatgt agacttaaat 6180 cagtttgata catcttcagt tgaagctgct atcaagactt gtatggaata taatgatact 6240 tgtacaatcg taatcaaaag tactattcct gaagggtata ctaaagaagt gagggaaaag 6300 tttaatacag atcgtattat tttttctcca gagtttctac gtgaatccaa agctttatat 6360 gataatttgt atccatctag aattgttgta ggaactgatt tggatgattc tgagttaaca 6420 aaaagagcat ggcagtttgc agatctactt aaaggtggag ctattaagga agaggttccg 6480 atactggttg ttgcttttaa tgaagcagag gttgcaaaat tgtttagtaa cacttacttg 6540 gcaactcgcg tacgttattt taatgagata gatacatata gcgaggtaaa agggcttaat 6600 cccaagacaa ttattgatat tgtttgttat gatcctagaa ttggatcata ctataataac 6660 cctagctttg gttacggagg gtattgctta ccaaaagaca caaagcaatt gaaagcaagt 6720 tttagggatg ttcctgaaaa tctgattaca gctgtggtgc aatctaataa aacaagaaaa 6780 gattatatag ctggagctat tctagctaaa caacctagtg ttgtaggtat ttatagatta 6840 attatgaaat ctgattctga taattttcgt tctagtgctg ttaagggagt tatggaacgt 6900 ttggacaatt atggtaaaga aattgttatt tacgaaccta ctattgagtg tgatactttt 6960 atgggataca gagtaattaa atctttagat gaatttaaga atatttctga cattgttgta 7020 gcgaatcgta tgaacgatga tttaagggat atacaagaaa aactctatac acgcgattta 7080 tttggcagag aataagggga aataattttt atgtatacat ttattttaat gttgttggat 7140 ttttttcaga atcatgattt tcatttcttt atgttgtttt ttgtctttat tcttattcgt 7200 tgggcggtta tatattttca tgctgtcaga tataagtcct acagttgtag tgtaagtgat 7260 gagaagttat ttagttctgt aattatccct gtcgtggatg aaccacttaa tctttttgaa 7320 agtgtactga atagaatttc cagacataaa ccatccgaaa ttattgtggt tattaacggc 7380 ccaaaaaacg agagacttgt aaaactttgt catgatttta atgaaaaatt agaaaataat 7440 atgactccaa ttcaatgtta ttacactcct gttcctggca agagaaatgc tatcctcttt 7500 gggctggagc atgtggattc gcagagtgat attacagttc tagtagatag tgatacagta 7560 tggacgccta gaaccttgag tgagttgctg aagccttttg tttgcgataa aaaaataggt 7620 ggggtaacga caagacaaaa aattcttgac cctgagcgta atctcgtgac aatgtttgct 7680 aacttgttag aggaaattag ggcagaagga actatgaaag caatgagtgt gactggtaaa 7740 gtagggtgct tacctggtcg aacaattgct tttagaacag agattctcag agagtgtata 7800 catgagttta tgaatgagac tttcatggga tttcataagg aagtttctga tgatagaagt 7860 cttacaaatt tgactttaaa aaaaggctat aaaactgtta tgcaggatac ttctgttgtg 7920 tatacagatg ctcctacaag ttggaaaaag ttcattagac agcaactaag gtgggcagaa 7980 ggttctcagt ataacaatct aaagatgact ccttggatga ttagaaatgc ccctcttatg 8040 ttttttattt attttacaga tatgatttta cctatgctac ttattagctt tggtgtgaat 8100 atattcctgt tgaaaatatt aaatataact acaattgttt atacagcttc atggtgggaa 8160 attattttat atgttctttt gggaatgatt tttagctttg gaggaagaaa ctttaaagct 8220 atgtctagaa tgaagtggta ttatgtattt cttattcctg tttttataat cgttttgagt 8280 ataattatgt gccctattag gctattagga cttatgagat gttctgatga tttagggtgg 8340 ggaactagga atttaacaga gtgagataaa tagtagtgcg tatatagagt atttactcag 8400 agtattaatt gatttttgaa aaggaaaagt gttttttaat gttaagaaag aacttgaaat 8460 atcagattat gacacgagct ggaacaattt tagctatctt gtttttcatt atattaggga 8520 ttattgttga agttttgttt taaggctcat tgtcatctgt agtggctcac ttcagacgta 8580 agggtcatat tttaatgtga aaagagtgtt aaaagattaa tcacttatat tattttaata 8640 gaaatagtgt aaggaattgt tatgaaaaaa gtaaaaaaag ctgttattcc tgctgcaggg 8700 ctgggcacac gatttttgcc tgccactaaa gctttggcaa aagaaatgct tccaattgta 8760 gaccgcccca caattcattt tgtcattgaa gaagctttac gttcgggtat tgaagatatt 8820 ctagtagtta ctggaaagag taaacgttct attgaagatt attttgattc aacttttgaa 8880 ttggaatata gtcttagaaa acaaggaaag atggaacttc ttaagtcagt taatgaatcg 8940 actgatatta aagtacattt cgttcgtcaa agttcaccac gtggtcttgg tgacgctgtt 9000 ctccaagcga agtcttttgt tggtgacgat ccctttgttg taatgcttgg tgatgacctt 9060 atggatatca ccgactcaac tgctgtacct ttaacaagac aattgatgga cgattacaac 9120 gcaacacagg cttcaactat cgcagtaatg cctgttagat atgaagatgt ttcttcttat 9180 ggtgtgattt ctcctagatt ggaaagtagt aatggcctct atagtgttga tgcttttgta 9240 gagaaaccaa aaccagaaga agcgcctagc aatttagcta ttattggacg ttatctactt 9300 actcctgaga ttttttctat attagaaacc caaaagccag gagcaggtaa tgaaattcaa 9360 ttgacagatg ctattgatac attgaataag acacagagtg tttttgcgcg tgaatttgtg 9420 ggcaaacgtt acgatgttgg tgataagttt aattttatga aaacatcaat tgattatgct 9480 cttcaacatc ctcagattaa agagagttta aaaaattacg ttattgcact tggtaagcaa 9540 ttggagaagc tagatgactg ttcgtcaagt ggacacctat gaattgtata gaaagttatc 9600 aaaaatggct aaatgtccct gatcttccag cttatttaaa agatgaattg ctcagcatgg 9660 atgacaaaac aaaagaagac gccttttaca caaaccttga attcggaaca gctggtatgc 9720 gtggttatat tggtgctggg acaaaccgta ttaatatcta tgtggtgcgt caagcaacag 9780 aaggccttgc caaattagtt gaatcaaaag gcgaaacggc caaaaaagct ggggttgcta 9840 ttgcctatga ctcgcgacat ttttcaccag aattcgcttt tgaatctgcc caagtattag 9900 cggcccatgg cattaaatct tatgtttttg aaagcctacg ccctactcct gagctgtctt 9960 ttgctgttcg tcatctcgga gcatttgctg gtattatggt aaccgccagt catacccctg 10020 ctccttttaa tggttataaa gtttacggtt ctgatggtgg gcaaatgctt ccagctgatg 10080 ctgatgcttt aactgactat attcgtgcga ttgataaccc atttgctgta gtccttgctg 10140 acttagaaga agctaaatca actggtctta ttgaagtaat tggtgaaact ctcgatgctg 10200 cctaccttga agaggttaaa agcgttaata tcaatgaaga tttgattgac caatacggtc 10260 gcgatatgca aattgtctac acacctcttc atggtactgg agaaatgcta gcacgtcgag 10320 ctttagcaca agctggtttc gaatctgttc aagttgtcga agctcaagca aaaccagacc 10380 cagacttctc aacagttgca tcaccaaacc ctgaaagtca agccgccttt gccttagctg 10440 aagaactagg gcgtcaagtc gatgctgatg tattagtggc gactgaccct gatgctgacc 10500 gtctcggtgt tgaaattcgt caagctgatg gcagttattg gaacctttct ggtaaccaaa 10560 tcggtgctct tatcgccaaa tacattttag aagctcacaa acaagctggg acactcccaa 10620 agaatgctgc attggcaaaa tcaatagtat caactgaatt agtcaccaaa attgcggaaa 10680 gctatggtgc aaccatgttt aacgtgttaa caggtttcaa attcatcgct gagaaaattc 10740 aagaatttga agaaaaacat aaccatacct acatgtttgg gtttgaagaa agctgatgag 10800 tttattgatt gcctccagct tggagttaga atagggcatc tggatggcat ttgtcacgta 10860 ttttctgtag cgaaccagcg tgctaagagc agttctaaag gcttgattga gttggggaaa 10920 agcctcagtt aacaagtcaa agaaatggtc ggcattcttt tcttgcaggt ggaaaagcag 10980 gagctggtaa agatcgtcat aatagtggag ctcatctgag aaagctaagg ttttattgac 11040 gatttctcga ggtgtcagtg tctgtctaaa agttcttgag tagaaggcct tatcagacag 11100 ttttcggcta tctttttgga aaattcgcca gtgatttttc atggcgcgat aggaaagtga 11160 ttgcttgtca aaattcttca tgatgacaat tctggttgtc atcatctcac ggcttaggtg 11220 ctggatgata tgaaatctat caaggacgat ttgtgcattt ggaaataggc atttaatcaa 11280 caagactcta ttacgtatct agttggtaca aatattgacc gtcagtccta taaatataac 11340 atctaagacc agtgaagaac aaaaaacatc tacgaaaaag gctctcttaa acaaggattt 11400 ccgtcaggct attgcatttg gatttgaccg tacagcctat gcctctcagt tgaatggaca 11460 aactggagca agcaaaatct tacgtaatct ctttgttcca ccaacatttg ttcaagcaga 11520 tggtaaaaac tttggcgata tggtcaaaga gaaattggtc acttatgggg atgaatggaa 11580 ggatgttaat cttgcagatt ctcaggatgg tctttacaat ccagaaaaag ccacggctga 11640 atttgctaaa gctaaattag ccttacaagc agaaggagtc caattcccaa ttcatttaga 11700 tatgccagtt gaccagacag caactacaaa agttcagcgc gtccaatcta tgaaacaatc 11760 cttggaagta actttaggag gctgataatg tcattattga tatccaacaa ctacaaaaag 11820 acgaagtaaa caatattaca tattttgctg aaaatgctgc tggcgaagac tgggatttat 11880 cagataatgt cggttggggt ccagactttg ccgatccatc aacctacctt gatatcatca 11940 aaccatctgt aggagaaagt actaaaacat atttagggtt tgactcaggg gaagataatg 12000 tagctgctaa aaaagtaggt ctatatgact acgaaaaatt ggttactgag gctggtgatg 12060 aggctacaga tgttgctaaa cgctatgata aatacgctgc agcccaagct tggttgacag 12120 atagtgcttt gattattcca actacatctc gtacagggcg tccaatcttg tctaagatgg 12180 taccatttac aataccattt gcattgtcag gaaataaagg tacaagtgaa ccaatcttat 12240 ataaatactt ggaacttcaa gacaaggcag tcactgtaga tgaataccaa aaagctcagg 12300 aaaaatggat gaaagaaaaa gaagagtcta ataaaaaggc tcaagaagat ctcgcaaaac 12360 atgtgaaata actgttgcaa aatataagaa aggatttagt atttcccttg aatgctgaat 12420 ccttttttac atttgtaaag aaagattcta aatgtacgga ccccaaaagt tggagtctct 12480 ttttgtcaga atagagaaaa tttttgttaa ttttacttgt ttcctattgc tttctcagtt 12540 attatttgtt atattaaaag tataattatt ttttatttat cagggttaag cattgcactt 12600 tcagaggaag gagtattttt taaaaagaaa atgtaaacgc ttgctcaaaa atgaaaggat 12660 ttagaagttt atgaataaag gattatttga aaaacgttgt aaatatagta ttcggaaatt 12720 ttcattaggt gttgcttctg ttatgattgg agctgcattc tttgggacaa gtccggttct 12780 tgcagatagc gtgcagtctg gttccacggc gaacttacca gctgatttag ctactgctct 12840 tgcaacagca aaagagaatg atgggcgtga ttttgaagcg cctaaggtgg gagaagacca 12900 aggttctcca gaagttacag atggacctaa gacagaagaa gaactattag cacttgaaaa 12960 agaaaaaccg gctgaagaaa aaccaaaaga ggataaacct gcagctgcta aacctgaaac 13020 acctaagacg gtaactcctg aatggcaaac ggtagagaaa aaagaacaac agggaacagt 13080 cactatccga gaagaaaaag gtgtccgcta caaccaatta tcctcaactg ctcaaaatga 13140 taacgcaggt aaaccagccc tgtttgaaaa gaagggcttg accgttgatg ccaatggaaa 13200 tgcaactgtt gatttaacct tcaaagatga ttctgaaaag ggcaaatcac gctttggtgt 13260 cttcttgaaa tttaaagata ccaagaataa tgtttttgtc ggttacgaca aggatggctg 13320 gttctgggag tataaatctc caacaactag cacttggtat agaggtagtc gtgttgctgc 13380 tcctgaaaca ggatcaacaa accgtctctc tatcactctc aagtcagacg gtcagctaaa 13440 tgccagcaat aacgatgtca atctctttga cacagtgact ctaccagctg cggtcaatga 13500 ccatcttaaa aatgagaaga agattcttct caaggcgggc tcttatgacg atgagcgaac 13560 agttgttagc gttaaaacgg ataaccaaga gggggtaaaa acagaggata cccctgctga 13620 aaaagaaaca ggtcctgaag ttgatgatag caaggtgact tatgacacga ttcagtctaa 13680 ggttctcaaa gcagtgattg accaagcctt cccctcgtgt caaggaatac agcttgaatg 13740 gacatacttt gccaggacag gttcaacagt tcaaccaagt ctttatcaat aaccaccgaa 13800 tcacccctga agtcacttat aagaaaatca atgagacaac agcagagtac ttgatgaacg 13860 ttcgcgatca tgctcactta atcaatgcgg aaatgacagt acgcttgcaa gttgtggaca 13920 atcaattgca ctttgatgtg accaagattg tcaaccacaa tcaagtcact ccaggtcaaa 13980 agattgatga cgaaagaaaa ctactttctt ctattagttt cctcggcaat gctttagtct 14040 ctgtttctag tgatca 14056 // |
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