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EBI DbfetchID Z23277; SV 1; linear; genomic DNA; STD; PRO; 7164 BP. XX AC Z23277; XX DT 02-MAY-1994 (Rel. 39, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 6) XX DE C.difficile gene for toxin B. XX KW toxin B. XX OS Clostridium difficile OC Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; OC Clostridium. XX RN [1] RC (sites) RX DOI; 10.1111/j.1365-2958.1995.mmi_17020313.x RX PUBMED; 7494480. RA von Eichel-Streiber C., Meyer zu Heringdorf D., Habermann E., Sartingen S.; RT "Closing in on the toxic domain through analysis of a variant Clostridium RT difficile cytotoxin B"; RL Mol. Microbiol. 17(2):313-321(1995). XX RN [2] RP 1-7164 RA Sartingen S.; RT ; RL Submitted (12-JUL-1993) to the EMBL/GenBank/DDBJ databases. RL Sartingen S., Johannes-Gutenberg-Universitaet Mainz, Institut fuer RL Medizinische Mikrobiologie, Obere Zahlbacher Strasse 67, Mainz, RL Rheinland-Pfalz, Germany, 55101 XX FH Key Location/Qualifiers FH FT source 1..7164 FT /organism="Clostridium difficile" FT /isolate="isolate 1470" FT /mol_type="genomic DNA" FT /clone_lib="genomic DNA in pUC18" FT /clone="pTBF1, pTBF3, pTBF4, pTBF5, pTBF6" FT /db_xref="taxon:1496" FT RBS 49..53 FT /citation=[1] FT CDS 61..7164 FT /transl_table=11 FT /product="toxin B" FT /db_xref="HSSP:1GVM" FT /db_xref="InterPro:IPR018337" FT /db_xref="UniProtKB/TrEMBL:Q46034" FT /citation=[1] FT /protein_id="CAA80815.1" FT /translation="MSLVNRKQLEKMANVRFRVQEDEYVAILDALEEYHNMSENTVVEK FT YLKLKDINSLTDTYIDTYKKSGRNKALKKFKEYLVIEILELKNSNLTPVEKNLHFIWIG FT GQINDTAINYINQWKDVNSDYNVNVFYDSNAFLINTLKKTIIESASNDTLESFRENLND FT PEFNHTAFFRKRMQIIYDKQQNFINYYKAQKEENPDLIIDDIVKTYLSNEYSKDIDELN FT AYIEESLNKVTENSGNDVRNFEEFKTGEVFNLYEQESVERWNLAGASDILRVAILKNIG FT GVYLDVDMLPGIHPDLFKDINKPDSVKTAVDWEEMQLEAIMKHKEYIPEYTSKHFDTLD FT EEVQSSFESVLASKSDKSEIFLPLGDIEVSPLEVKIAFAKGSIINQALISAKDSYCSDL FT LIKQIQNRYKILNDTLGPIISQGNDFNTTMNNFGESLGAIANEENISFIAKIGSYLRVG FT FYPEANTTITLSGPTIYAGAYKDLLTFKEMSIDTSILSSELRNFEFPKVNISQATEQEK FT NSLWQFNEERAKIQFEEYKKNYFEGALGEDDNLDFSQNTVTDKEYLLEKISSSTKSSEG FT GYVHYIVQLQGDKISYEAACNLFAKNPYDSILFQRNIEDSEVAYYYNPTDSEIQEIDKY FT RIPDRISDRPKIKLTFIGHGKAEFNTDIFAGLDVDSLSSEIETAIGLAKEDISPKSIEI FT NLLGCNMFSYSVNVEETYPGKLLLRVKDKVSELMPSMSQDSIIVSANQYEVRINSEGRR FT ELLDHSGEWINKEESIIKDISSKEYISFNPKENKIIVKSKNLPELSTLLQEIRNNSNSS FT DIELEEKVMLAECEINVISNIETQVVEERIEEAKSLTSDSINYIKNEFKLIESISEALC FT DLKQQNELEDSHFISFEDISETDEGFSIRFINKETGESIFVETEKTIFSEYANHITEEI FT SKIKGTIFDTVNGKLVKKVNLDTTHEVNTLNAAFFIQSLIEYNSSKESLSNLSVAMKVQ FT VYAQLFSTGLNTITDAAKVVELVSTALDETIDLLPTLSEGLPIIATIIDGVSLGAAIKE FT LSETSDPLLRQEIEAKIGIMAVNLTTATTAIITSSLGIASGFSILLVPLAGISAGIPSL FT VNNELVLRDKATKVVDYFKHVSLVETEGVFTLLDDKVMMQQDDLVISEIDFNNNSIVLG FT KCEIWRMEGGSGHTVTDDIDHFFSAPSITYREPHLSIYDVLEVQKEELDLSKDLMVLPN FT APNRVFAWETGWTPGLRSLENDGTKLLDRIRDNYEGEFYWRYFAFIADALITTLKPRYE FT DTNIRINLDSNTRSFIVPIITTEYIREKLSYSFYGSGGTYALPLSQYNMGINIELSESD FT VWIIDVDNVVRDVTIESDKIKKGDLIEGILSTLSIEENKIILNSHEINFSGEVNGSNGF FT VSLTFSILEGINAIIEVDLLSKSYKLLISGELKILMLNSNHIQQKIDYIGFNSELQKNI FT PYSFVDSEGKENGFINGSTKEGLFVSELPDVVLISKVYMDDSKPSFGYYSNNLKDVKVI FT TKDNVNILTGYYLKDDIKISLSLTLQDEKTIKLNSVHLDESGVAEILKFMNRKGSTNTS FT DSLMSFLESMNIKSIFVNFLQSNIKFILDANFIISGTTSIGQFEFICDENNNIQPYFIK FT FNTLETNYTLYVGNRQNMIVEPNYDLDDSGDISSTVINFSQKYLYGIDSCVNKVVISPN FT IYTDEINITPVYETNNTYPEVIVLDANYINEKINVNINDLSIRYVWSNDGNDFILMSTS FT EENKVSQVKIRFVNVFKDKTLANKLSFNFSDKQDVPVSEIILSFTPSYYEDGLIGYDLG FT LVSLYNEKFYINNFGMMVSGLIYINDSLYYFKPPVNNLITGFVTVGDDKYYFNPINGGA FT ASIGETIIDDKNYYFNQSGVLQTGVFSTEDGFKYFAPANTLDENLEGEAIDFTGKLIID FT ENIYYFEDNYRGAVEWKELDGEMHYFSPETGKAFKGLNQIGDDKYYFNSDGVMQKGFVS FT INDNKHYFDDSGVMKVGYTEIDGKHFYFAENGEMQIGVFNTEDGFKYFAHHNEDLGNEE FT GEEISYSGILNFNNKIYYFDDSFTAVVGWKDLEDGSKYYFDEDTAEAYIGLSLINDGQY FT YFNDDGIMQVGFVTINDKVFYFSDSGIIESGVQNIDDNYFYIDDNGIVQIGVFDTSDGY FT KYFAPANTVNDNIYGQAVEYSGLVRVGEDVYYFGETYTIETGWIYDMENESDKYYFVPE FT TKKACKGINLIDDIKYYFDEKGIMRTGLISFENNNYYFNENGEIQFGYINIEDKMFYFG FT EDGVMQIGVFNTPDGFKYFAHQNTLDENFEGESINYTGWLGLDEKRYYFTDEYIAATGS FT VIIDGEEYYFDPDTAQLVISE" FT repeat_region 5614..7161 FT /rpt_type=DISPERSED FT /citation=[1] XX SQ Sequence 7164 BP; 2828 A; 730 C; 1234 G; 2372 T; 0 other; gttttagcat ttagatgtaa aaatatttaa taaaaatatt atagtaaagg agaaaatttt 60 atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtgttcag 120 gaagatgaat atgtagcaat attagatgca ttagaagaat atcataatat gtcagaaaat 180 actgtagttg aaaagtatct aaaattaaaa gatataaaca gtttaacaga tacttatata 240 gatacatata aaaaatctgg tcgaaataaa gccttaaaaa aatttaaaga gtacttagtt 300 atagagatat tagaattaaa aaatagcaat ttaactccag tcgagaaaaa tttacatttt 360 atatggattg gagggcaaat aaatgatact gctattaatt atataaatca atggaaagat 420 gtaaatagtg actataatgt taatgttttt tatgatagta atgcattttt gataaacaca 480 ttgaaaaaaa ctataataga atcagcatca aatgataccc ttgaatcatt tagagaaaat 540 ttaaatgatc ctgaatttaa ccacactgca tttttcagaa aacgtatgca aataatctat 600 gataaacagc aaaatttcat aaattactat aaagctcaaa aagaagaaaa tcctgacctt 660 ataattgatg atattgtaaa gacatatctt tcaaacgagt attcaaagga tatagatgaa 720 cttaatgctt atattgaaga gtcattaaac aaagtcacag aaaatagtgg aaatgatgtt 780 agaaactttg aagaatttaa aactggagaa gtattcaatt tatatgaaca agagtcagta 840 gaaagatgga atcttgctgg tgcatctgat atattaagag tcgctatatt gaaaaatatt 900 ggtggagtct atctagatgt tgatatgtta ccaggaatac acccagattt atttaaagat 960 ataaataagc ctgattcagt aaagacagct gtagattggg aagagatgca gttagaagcc 1020 ataatgaaac ataaagaata tataccagaa tatacttcaa aacattttga tacattggat 1080 gaagaagttc aaagtagctt tgaatctgtt ttagcttcta agtctgataa gtcagaaata 1140 tttttaccac taggagatat agaggtatca cctttagaag taaaaattgc atttgccaaa 1200 ggttctatta taaatcaagc tctaatttct gcaaaagatt catattgtag tgacttacta 1260 ataaaacaaa tccaaaacag atataagata ctgaatgata ctttaggtcc aattattagt 1320 caaggtaatg attttaatac tacaatgaac aattttggtg aaagtttggg agctatagct 1380 aatgaagaga atataagttt tatagcaaaa atcggaagtt atttaagggt tggattttat 1440 cctgaagcta atactacaat tactttaagt ggtcctacaa tatatgcagg agcttataaa 1500 gatttattaa catttaaaga gatgagcata gatacttcta tattgtcatc tgagttaaga 1560 aattttgaat ttcctaaggt taatatatct caagcaacag aacaagagaa aaatagttta 1620 tggcaattta atgaagaaag agctaaaatt caatttgaag aatacaagaa aaattatttt 1680 gaaggtgcac ttggagaaga tgataatctt gatttttctc aaaatacagt aactgacaaa 1740 gaatatcttt tagaaaagat ctcttcatca acgaagagtt cagaaggagg atatgttcat 1800 tatattgttc aattacaagg agataaaatt agctatgaag cagcatgtaa cttatttgca 1860 aaaaatcctt atgacagtat actatttcaa agaaatatag aagattcaga agtagcatat 1920 tactataatc ctacagatag tgaaatacaa gaaattgata agtatagaat tcctgataga 1980 atctctgata gacctaagat taaattaaca ttcattggtc atggcaaagc tgaatttaat 2040 actgatatat ttgcaggtct tgatgtagat tcattatctt cagaaataga aacagcaata 2100 ggtttagcca aagaggatat ttctcctaaa tctatagaaa taaacttact gggatgtaac 2160 atgtttagct attctgtaaa tgtagaagag acttatcctg ggaaattatt acttagagtt 2220 aaagataaag tatcagaatt aatgccatct atgagtcaag actctattat agtaagtgca 2280 aatcaatatg aagttagaat aaatagtgaa ggaagaagag aattattaga ccattctggt 2340 gaatggataa acaaagaaga aagtattata aaggatattt catcaaaaga atatatatca 2400 tttaatccta aagagaataa aattatagta aaatctaaaa atttacctga attatctaca 2460 ttattacaag aaattagaaa taattctaat tcaagtgata ttgaactaga agaaaaagta 2520 atgttagcag aatgtgagat aaatgttatt tcaaatatag agacacaagt ggtagaagaa 2580 agaattgaag aagctaaaag cttaacttct gactctatta attatataaa gaatgaattt 2640 aaactaatag aatctatttc tgaggcacta tgtgacttaa aacaacagaa tgaattagaa 2700 gattctcatt ttatatcttt tgaggacata tcagagactg atgaggggtt tagtataaga 2760 tttattaata aagaaactgg agaatctata tttgtagaaa ctgaaaaaac aatattctct 2820 gaatatgcta atcatataac tgaagagatt tctaagataa aaggtactat atttgatact 2880 gtaaatggta agttagtaaa aaaagtaaat ttagatacta cacacgaagt aaatacttta 2940 aatgctgcat tttttataca atcattaata gaatataata gttctaaaga atctcttagt 3000 aatttaagtg tagcaatgaa agttcaagtt tacgctcaat tatttagtac tggtttaaat 3060 actattacag atgcagccaa agttgttgaa ttagtatcaa ctgcattaga tgaaactata 3120 gacttacttc ctacattatc tgaaggatta cctataattg caactattat agatggtgta 3180 agtttaggtg cagcaatcaa agagctaagt gaaacgagtg acccattatt aagacaagaa 3240 atagaagcta agataggtat aatggcagta aatttaacaa cagctacaac tgcaatcatt 3300 acttcatctt tggggatagc tagtggattt agtatacttt tagttccttt agcaggaatt 3360 tcagcaggta taccaagctt agtaaacaat gaacttgtac ttcgagataa ggcaacaaag 3420 gttgtagatt attttaaaca tgtttcatta gttgaaactg aaggagtatt tactttatta 3480 gatgataaag taatgatgca acaagatgat ttagtgatat cagaaataga ttttaataat 3540 aattcaatag ttttaggtaa atgtgaaatc tggagaatgg aaggtggttc aggtcatact 3600 gtaactgatg atatagatca cttcttttca gcaccatcaa taacatatag agagccacac 3660 ttatctatat atgacgtatt ggaagtacaa aaagaagaac ttgatttgtc aaaagattta 3720 atggtattac ctaatgctcc aaatagagta tttgcttggg aaacaggatg gacaccaggt 3780 ttaagaagct tagaaaatga tggcacaaaa ctgttagacc gtataagaga taactatgaa 3840 ggtgagtttt attggagata ttttgctttt atagctgatg ctttaataac aacattaaaa 3900 ccaagatatg aagatactaa tataagaata aatttagata gtaatactag aagttttata 3960 gttccaataa taactacaga atatataaga gaaaaattat catattcttt ctatggttca 4020 ggaggaactt atgcattgcc tctttctcaa tataatatgg gtataaatat agaattaagt 4080 gaaagtgatg tttggattat agatgttgat aatgttgtga gagatgtaac tatagaatct 4140 gataaaatta aaaaaggtga tttaatagaa ggtattttat ctacactaag tattgaagag 4200 aataaaatta tcttaaatag ccatgagatt aatttttctg gtgaggtaaa tggaagtaat 4260 ggatttgttt ctttaacatt ttcaatttta gaaggaataa atgcaattat agaagttgat 4320 ttattatcta aatcatataa attacttatt tctggcgaat taaaaatatt gatgttaaat 4380 tcaaatcata ttcaacagaa aatagattat ataggattca atagcgaatt acagaaaaat 4440 ataccatata gctttgtaga tagtgaagga aaagagaatg gttttattaa tggttcaaca 4500 aaagaaggtt tatttgtatc agaattacct gatgtagttc ttataagtaa ggtttatatg 4560 gatgatagta agccttcatt tggatattat agtaataatt tgaaagatgt caaagttata 4620 actaaagata atgttaatat attaacaggt tattatctta aggatgatat aaaaatctct 4680 ctttctttga ctctacaaga tgaaaaaact ataaagttaa atagtgtgca tttagatgaa 4740 agtggagtag ctgagatttt gaagttcatg aatagaaaag gtagtacaaa tacttcagat 4800 tctttaatga gctttttaga aagtatgaat ataaaaagta ttttcgttaa tttcttacaa 4860 tctaatatta agtttatatt agatgctaat tttataataa gtggtactac ttctattggc 4920 caatttgagt ttatttgtga tgaaaataat aatatacaac catatttcat taagtttaat 4980 acactagaaa ctaattatac tttatatgta ggaaatagac aaaatatgat agtggaacca 5040 aattatgatt tagatgattc tggagatata tcttcaactg ttatcaattt ctctcaaaag 5100 tatctttatg gaatagacag ttgtgttaat aaagttgtaa tttcaccaaa tatttataca 5160 gatgaaataa atataacgcc tgtatatgaa acaaataata cttatccaga agttattgta 5220 ttagatgcaa attatataaa cgaaaaaata aatgttaata tcaatgatct atctatacga 5280 tatgtatgga gtaatgatgg taatgatttt attcttatgt caactagtga agaaaataag 5340 gtgtcacaag ttaaaataag attcgttaat gtttttaaag ataagacttt ggcaaataag 5400 ctatctttta actttagtga taaacaagat gtacctgtaa gtgaaataat cttatcgttt 5460 acaccttcat attatgagga tggattgatt ggctatgatt tgggtctagt ttctttatat 5520 aatgagaaat tttatattaa taactttgga atgatggtat ctggattaat atatattaat 5580 gattcattat attattttaa accaccagta aataatttga taactggatt tgtgactgta 5640 ggcgatgata aatactactt taatccaatt aatggtggag ctgcttcaat tggagagaca 5700 ataattgatg acaaaaatta ttatttcaac caaagtggag tgttacaaac aggtgtattt 5760 agtacagaag atggatttaa atattttgcc ccagctaata cacttgatga aaacctagaa 5820 ggagaagcaa ttgattttac tggaaaatta attattgacg aaaatattta ttattttgaa 5880 gataattata gaggagctgt agaatggaaa gaattagatg gtgaaatgca ctattttagc 5940 ccagaaacag gtaaagcttt taaaggtcta aatcaaatag gtgatgataa atactatttc 6000 aattctgatg gagttatgca aaaaggattt gttagtataa atgataataa acactatttt 6060 gatgattctg gtgttatgaa agtaggttac actgaaatag atggcaagca tttctacttt 6120 gctgaaaacg gagaaatgca aataggagta tttaatacag aagatggatt taaatatttt 6180 gctcatcata atgaagattt aggaaatgaa gaaggtgaag aaatctcata ttctggtata 6240 ttaaatttca ataataaaat ttactatttt gatgattcat ttacagctgt agttggatgg 6300 aaagatttag aggatggttc aaagtattat tttgatgaag atacagcaga agcatatata 6360 ggtttgtcat taataaatga tggtcaatat tattttaatg atgatggaat tatgcaagtt 6420 ggatttgtca ctataaatga taaagtcttc tacttctctg actctggaat tatagaatct 6480 ggagtacaaa acatagatga caattatttc tatatagatg ataatggtat agttcaaatt 6540 ggtgtatttg atacttcaga tggatataaa tattttgcac ctgctaatac tgtaaatgat 6600 aatatttacg gacaagcagt tgaatatagt ggtttagtta gagttggtga agatgtatat 6660 tattttggag aaacatatac aattgagact ggatggatat atgatatgga aaatgaaagt 6720 gataaatatt atttcgttcc agaaactaaa aaagcatgca aaggtattaa tttaattgat 6780 gatataaaat attattttga tgagaagggc ataatgagaa cgggtcttat atcatttgaa 6840 aataataatt attactttaa tgagaatggt gaaatccaat ttggttatat aaatatagaa 6900 gataagatgt tctattttgg tgaagatggt gtcatgcaga ttggagtatt taatacacca 6960 gatggattta aatactttgc acatcaaaat actttggatg agaattttga gggagaatca 7020 ataaactata ctggttggtt aggtttagat gaaaagagat attattttac agatgaatat 7080 attgcagcaa ctggttcagt tattattgat ggtgaggagt attattttga tcctgataca 7140 gctcaattag tgattagtga atag 7164 // |
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