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EBI DbfetchID Y09927; SV 2; linear; genomic DNA; STD; PRO; 15310 BP. XX AC Y09927; XX DT 09-DEC-1996 (Rel. 50, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 7) XX DE Staphylococcus aureus glmM gene cluster XX KW arginase; glmM gene; mannitol-1-phosphate 5-dehydrogenase; KW mannitol-specific IIA component; phosphoglucosamine mutase. XX OS Staphylococcus aureus OC Bacteria; Firmicutes; Bacillales; Staphylococcus. XX RN [1] RC Revised by [4] RA Wu S.W.; RT ; RL Submitted (19-NOV-1996) to the EMBL/GenBank/DDBJ databases. RL Wu S.W., Laboratory of Microbiology, The Rockefeller University, 1230 York RL Avenue, New York, NY 10021, USA XX RN [2] RX PUBMED; 9158773. RA Wu S., de Lencastre H., Sali A., Tomasz A.; RT "A phosphoglucomutase-like gene essential for the optimal expression of RT methicillin resistance in Staphylococcus aureus: molecular cloning and DNA RT sequencing"; RL Microb. Drug Resist. 2(2):277-286(1996). XX RN [3] RX PUBMED; 9286983. RA Jolly L., Wu S.W., Van Heijenoort J., de Lencastre H., Mengin-Lecreulx D., RA Tomasz A.; RT "The femR315 gene from Staphylococcus aureus, the interruption of which RT results in reduced methicillin resistance, encodes a phosphoglucosamine RT mutase"; RL J. Bacteriol. 179(17):5321-5325(1997). XX RN [4] RP 1-15310 RA Wu S.W.; RT ; RL Submitted (01-SEP-1999) to the EMBL/GenBank/DDBJ databases. RL Wu S.W., Laboratory of Microbiology, The Rockefeller University, 1230 York RL Avenue, New York, NY 10021, USA XX RN [5] RA Wu S., de Lencastre H., Tomasz A.; RT "Transcriptional analysis of arginase gene cluster in Staphylococcus RT aureus"; RL Unpublished. XX RN [6] RX PUBMED; 10332717. RA Wu S., de Lencastre H.; RT "Mrp--a new auxiliary gene essential for optimal expression of methicillin RT resistance in Staphylococcus aureus"; RL Microb. Drug Resist. 5(1):9-18(1999). XX CC Related Swiss-Prot accession numbers: P17876, Q02418 XX FH Key Location/Qualifiers FH FT source 1..15310 FT /organism="Staphylococcus aureus" FT /strain="COL" FT /mol_type="genomic DNA" FT /note="SmaI I-fragment; highly methicillin-resistant FT strain" FT /db_xref="taxon:1280" FT CDS 987..1895 FT /transl_table=11 FT /gene="arg" FT /product="arginase" FT /db_xref="GOA:P60086" FT /db_xref="HSSP:2CEV" FT /db_xref="InterPro:IPR006035" FT /db_xref="UniProtKB/Swiss-Prot:P60086" FT /protein_id="CAB55326.1" FT /translation="MTKTKAIDIIGAPSTFGQRKLGVDLGPTAIRYAGLISRLKQLDLD FT VYDKGDIKVPAVNIEKFHSEQKGLRNYDEIIDVNQKLNKEVSASIENNRFPLVLGGDHS FT IAVGSVSAISKHYNNLGVIWYDAHGDLNIPEESPSGNIHGMPLRILTGEGPKELLELNS FT NVIKPENIVLIGMRDLDKGERQFIKDHNIKTFTMSDIDKLGIKEVIENTIEYLKSRNVD FT GVHLSLDVDALDPLETPGTGTRVLGGLSYRESHFALELLHQSHLISSMDLVEVNPLIDS FT NNHTAEQAVSLVGTFFGETLL" FT CDS 2084..2893 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF269" FT /db_xref="InterPro:IPR003390" FT /db_xref="UniProtKB/TrEMBL:Q9RL70" FT /protein_id="CAB55327.1" FT /translation="MDFSNFFQNLSTLKIVTSILDLLIVWYVLYLLITVFKGTKAIQLL FT KGILVIVIGQQISMILNLTATSKLFDIVIQWGVLALIVIFQPEIRRALEQLGRGSFLKR FT YTSNTYSKDEEKLIQSVSKAVQYMAKRRIGALIVFEKETGLQDYIETGIAMDSNISQEL FT LINVFIPNTPLHDGAMIIQGTKIAAAASYLPLSDSPKISKSLGTRHRAAVGISEVSDAF FT TVIVSEETGDISVTFDGKLRRDISNEIFEELLAEHWFGTRFQKKGVK" FT CDS 2895..3827 FT /transl_table=11 FT /product="hypothetical protein" FT /note="ORF310" FT /db_xref="InterPro:IPR012505" FT /db_xref="UniProtKB/TrEMBL:Q9ZAI5" FT /protein_id="CAB55328.1" FT /translation="MLESKWGLRFIAFLLALFFFLSVNNVFGNIFNTGNLGQKSSKTIQ FT DVPVEILYNTKDLHLTKAPETVNVTISGPQSKIIKIENPEDLRVVIDLSNAKAGKYQEK FT YQVKGLADDIHYSVKPKLANITLENKVTKKMTVQPDVSQSDIDPLYKITKQEVSPQTVK FT VTGGEEQLNDIAYLKATFKTNKKINGDTKDVAEVTAFDKKLNKLNVSIQPNEVNLQVKV FT EPFSKKVKVNVKQKGSLADDKELSSIDLEDKEIEIFGSRDDLQNISEVDAEVDLDGISE FT STEKTVKINLPEHVTKAQPSETKAYINVK" FT CDS 3854..5209 FT /transl_table=11 FT /gene="glmM" FT /product="phosphoglucosamine mutase, GlmM" FT /function="essential for optimal methicillin resistance; FT catalyzes formation of phosphoglucosamine-1-phosphate from FT phosphoglucosamine-6-phosphate" FT /db_xref="GOA:Q5HE43" FT /db_xref="InterPro:IPR016055" FT /db_xref="UniProtKB/Swiss-Prot:Q5HE43" FT /protein_id="CAA71060.2" FT /translation="MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRV FT LVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHN FT PVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLS FT YLKSTVDVNFEGLKIALDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTH FT PEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDM FT IVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTT FT GDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKV FT EVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK" FT CDS 5486..12922 FT /transl_table=11 FT /gene="mrp" FT /product="Mrp protein" FT /function="essential for optimal methicillin resistance" FT /note="membrane or cell wall protein" FT /db_xref="GOA:Q9RL69" FT /db_xref="InterPro:IPR019931" FT /db_xref="UniProtKB/TrEMBL:Q9RL69" FT /protein_id="CAB55329.1" FT /translation="MNLFRQQKFSIRKFNVGIFSALIATVTFISTNPTTASAAEQNQPA FT QNQPAQPADANTQPNANAGAQANPTAQPAAPANQGQPAVQPANQGGQANPAGGAAQPNT FT QPAGQGNQADPNNAAQAQPGNQATPANQAGQGNNQATPNNNATPANQTQPANAPAAAQP FT AAPVAANAQTQDPNASNTGEGSINTTLTFDDPAISTDENRQDPTVTVTDKVNGYSLINN FT GKIGFVNSELRRSDMFDKNNPQNYQAKGNVAALGRVNANDSTDHGNFNGISKTVNVKPD FT SELIINFTTMQTNSKQGATNLVIKDAKKNTELATVNVAKTGTAHLFKVPTDADRLDLQF FT IPDNTAVADASRITTNKDGYKYYSFIDNVGLFSGSHLYVKNRDLAPKATNNKEYTINTE FT IGNNGNFGASLKADQFKYEVTLPQGVTYVNNSLTTTFPNGNEDSTVLKNMTVNYDQNAN FT KVTFTSQGVTTARGTHTKEVLFPDKSLKLSYKVNVANIDTPKNIDFNEKLTYRTASDVV FT INNAQPEVTLTADPFSVAVEMNKDALQQQVNSQVDNSHYTTASIAEYNKLKQQADTILN FT EDANHVKTANRASQADIDGLVTKLQAALIDNQAAIAELDTKAQEKVTAAQQSKKVTQDE FT VAALVTKINNDKNNAIAEINKQTTAQGVTTEKDNGIAVLEQDVITPTVKPQAKQDIIQA FT VTTRKQQIKKSNASLQDEKDVANDKIGKIETKAIKDIDAATTNAQVEAIKTKAINDINQ FT TTPATTAKAAALEEFDEVVQAQIDQAPLNPDTTNEEVAEAIERINAAKVSGVKAIEATT FT TAQDLERVKNEEISKIENITDSTQTKMDAYNEVKQAATARKAQNATVSNATNEEVAEAD FT AAVDAAQKQGLHDIQVVKSKQEVADTKSKVLDKINAIQTQAKVKPAADTEVENAYNTRK FT QEIQNSNASTTEEKQAAYTELDTKKQEARTNLDAANTNSDVTTAKDNSIAAINQVQAAT FT TKKSDAKAEIAQKASERKTAIEAMNDSTTEEQQAAKDKVDQAVVTANADIDNAAANNDV FT DNAKTTNEATIAAITPDANVKPAAKQAIADKVQAQETAIDGNNGSTTEEKAAAKQQVQT FT EKTTADAAIDAAHTNAEVEAAKKAAIAKIEAIQPATTTKDNAKEAIATKANERKTAIAQ FT TQDITAEEIAAANADVDNAVTQANSNIEAANSQNDVDQAKTTGENSIDQVTPTVNKKAT FT ARNEITAILNNKLQEIQATPDATDEEKQAADAEANTENGKANQAISAATTNAQVDEAKA FT NAEAAINAVTPKVVKKQAAKDEIDQLQATQTNVINNDQNATTEEKEAAIQQLATAVTDA FT KNNITAATDDNGVDQAKDAGKNSIQSTQPATAVKSNAKNDVDQAVTTQNQAIDNTTGAT FT TEEKNAAKDLVLKAKEKAYQDILNAQTTNDVTQIKDQAVADIQGITADTTIKDVAKDEL FT ATKANEQKALIAQTADATTEEKEQANQQVDAQLTQGNQNIENAQSIDDVNTAKDNAIQA FT IDPIQASTDVKTNARAELLTEMQNKITEILNNNETTNEEKGNDIGPVRAAYEEGLNNIN FT AATTTGDVTTAKDTAVQKVQQLHANPVKKPAGKKELDQAAADKKTQIEQTPNASQQEIN FT DAKQEVDTELNQAKTNVDQSSTNEYVDNAVKEGKAKINAVKTFSEYKKDALAKIEDAYN FT AKVNEADNSNASTSSEIAEAKQKLAELKQTADQNVNQATSKDDIEVQIHNDLDNINDYT FT IPTGKKESATTDLYAYADQKKNNISADTNATQDEKQQAIKQVDQNVQTALESINNGVDN FT GDVDDALTQGKAAIDAIQVDATVKPKANQAIEVKAEDTKESIDQSDQLTAEEKTEALAM FT IKQITDQAKQGITDATTTAEVEKAKAQGLEAFDNIQIDSTEKQKAIEELETALDQIEAG FT VNVNADATTEEKEAFTNALEDILSKATEDISDQTTNAEIATVKNSALEQLKAQRINPEV FT KKNALEAIREVVNKQIEIIKNADADASAKEIARTDLGRYFDRFADKLDKTQTNAEVAEL FT QNVTIPAIEAIVPQNDPDANDTNNGIDNNDATANSNANATPENTGQPNVSETTANGKAD FT ASPTTPNNSDAATGETTATSATDDANDKPQANNNSSVDASTNSPTMDNDVTSKPEVEST FT NNGTTDKPVTETDNATPAESTTNNNSTTTATNENAPTGSTATAPTTASTEAASSADSKD FT NASVNDSKQNAEVNNSAESQSTNDKVAQPKSENKAKAEKDGSDSTNQSMVESTTETLPS FT ADITEPNVPSNTSKDKEESTTNQTDAGQLKSETNVASNEADKSPSKADTEVSNKPSTSA FT SSEAKEKMTSTNLSQKDDTATADTNDTQKSVGSAANNKATQNDGANASPATVSNGSNSA FT NQDMLNVTNTDDHQAKTKSAQQGKVNKAKQQAKTLPDTGMSHNDDLPYAELALGAGMAF FT LIRRFTKKDQQTEE" FT CDS complement(13241..14347) FT /transl_table=11 FT /product="putative mannitol-1-phosphate 5-dehydrogenase" FT /note="ORF368" FT /db_xref="GOA:Q9RL68" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:Q9RL68" FT /protein_id="CAB55330.1" FT /translation="MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQ FT YDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPF FT LKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILD FT VMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFAGKAT FT VLDAVEDSSIEAGLRRVLAETSQYITNEFDFTEAEQAAYVEKIIDRFNNSYLSDEVTRV FT GRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEH FT GLKAFLSEYAKVDDGLADEIIEAYNSLS" FT CDS complement(14347..14781) FT /transl_table=11 FT /product="putative mannitol-specific IIA component" FT /note="ORF144" FT /db_xref="GOA:Q5HE46" FT /db_xref="InterPro:IPR002178" FT /db_xref="UniProtKB/Swiss-Prot:Q5HE46" FT /protein_id="CAB55331.1" FT /translation="MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMK FT DREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDG FT EHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA" XX SQ Sequence 15310 BP; 5938 A; 2470 C; 2686 G; 4216 T; 0 other; caatttaaat gttgaacgat atggaatctg tcaaaaataa tagctgcatt aggaaatagg 60 tcgcgaaata atcggacata gggttcatac atgtcaatag taaccgtctt aacttgttgt 120 cgatttttta aatcgaatcg ctcgaaatag gcacgcaaga atcttgtagt tctattttct 180 aaaatatcta taacatcatg agtatcatta tctataaaaa tgaaactcat tgatccagtt 240 acatttttaa cgcttttaaa ttcatccata gcgatgtgtt ctggcaaaca attaaagggt 300 ttaattcgta atgaattagc cgctttagtt ctaatacgac ttacagtaga tggagagata 360 cagttatctt ctgcagtatc aatctctgtt ttaactttag tagcttcttc tataactttt 420 tgagtaacac atcttgagat aaaacacgac tcatcaacaa ttgacgtttt agcagtaaaa 480 gtgccattgc attctaagca tttaaaacgt tgtttagcta agttgaggta tgtgttatac 540 ccttgagttt taagtaaagt aatacgagaa acacgcttac catgtttatg aatttgtcct 600 tcatttttaa ctccacaaca ataacaggcc gaaggcttat acgttagtac agcattaacc 660 actgttgctt tttttccttt gataatgacg tcaatttctt ggtttatata ttttatattt 720 tcatctttta ttcttagtaa ttctaaggta tcattacaca taggcgcact tgtctccttt 780 agtttgggtt tggtcacttt aaattataga ggcaattgcg ctttttgtgt attaaaaaaa 840 gcaggaagtt ttaccttccc accataaaag atgaagaacc tttttttatg aagtaataag 900 ataaacagat tatatgtgta gctattgctt gataatggta agcgcataca ttattcttta 960 attacataga gcaaaggggg acgcttatga caaagacaaa agcaattgat attataggtg 1020 caccatcaac atttggacaa agaaaattag gtgttgattt aggaccaaca gcaattagat 1080 atgctggatt aatttcaaga ttaaagcaat tagaccttga tgtatatgac aagggggata 1140 ttaaggtacc tgctgtgaac attgaaaaat ttcatagtga acaaaaagga ttaagaaatt 1200 atgatgaaat tatagatgtt aatcaaaaat taaataaaga ggtttcagca tcaattgaaa 1260 ataacagatt tcctctagtt cttggtggag atcattctat tgcggtaggt tcagtatcag 1320 caataagtaa acattataat aatttaggtg ttatttggta tgatgcacat ggtgatttaa 1380 atatacctga agagtcacca agtggaaata ttcatggtat gcctctaagg attttgacag 1440 gcgaaggtcc caaagaactt ttagaattaa atagtaatgt aatcaagcca gaaaacatcg 1500 tactaattgg tatgagagat ttagataaag gtgaaagaca atttatcaaa gatcataata 1560 ttaaaacatt tactatgtca gatattgata aattggggat aaaggaagta attgaaaata 1620 caatagaata tttgaagtca cgcaatgttg atggcgttca tttatcttta gatgttgatg 1680 ctttagatcc gcttgaaacg ccaggcactg gtactagagt tttgggtggt cttagttata 1740 gagaaagcca ttttgcattg gaattactgc atcaatcaca tttaatttcc tcaatggatt 1800 tagttgaagt aaatccattg attgacagta ataatcatac tgctgaacaa gcggtttcat 1860 tagttggaac attttttggt gaaactttat tataaataaa tgatttgtag tgtataaagt 1920 atattttgct ttttgcacta ctttttttaa ttcactaaaa tgattaagag tagttataat 1980 ctttaaaata aattttttct atttaaatat atgttcgtat gacagtgatg taaatgattg 2040 gtataatggg tattatggaa aaatattacc cggaggagat gttatggatt tttccaactt 2100 ttttcaaaac ctcagtacgt taaaaattgt aacgagtatc cttgatttac tgatagtttg 2160 gtatgtactt tatcttctca tcacggtctt taagggaact aaagcgatac aattacttaa 2220 agggatatta gtaattgtta ttggtcagca gataagtatg atattgaact tgactgcaac 2280 atctaaatta ttcgatatcg ttattcaatg gggggtatta gctttaatag taatattcca 2340 accagaaatt agacgtgcgt tagaacaact tggtagaggt agctttttaa aacgctatac 2400 ttctaatacg tatagtaaag atgaagagaa attgattcaa tcggtttcaa aggctgtgca 2460 atatatggct aaaagacgta taggtgcatt aattgtcttt gaaaaagaaa caggtcttca 2520 agattatatt gaaacaggta ttgcaatgga ttcaaatatt tcgcaagaac ttttaattaa 2580 tgtctttata cctaacacac ctttacatga tggtgcaatg attattcaag gcacgaagat 2640 tgcagcagca gcaagttatt tgccattgtc tgatagtcct aagatatcta aaagtttggg 2700 tacaagacat agagctgcgg ttggtatttc agaagtatct gatgcattta ccgttattgt 2760 atctgaagaa actggtgata tttcggtaac atttgatgga aaattacgac gagacatttc 2820 aaacgaaatt tttgaagagt tgcttgctga acattggttt ggcacacgct ttcaaaagaa 2880 aggtgtgaaa taatatgcta gaaagtaaat ggggcttgag atttattgcc tttcttttgg 2940 cattgttttt ctttttatct gttaacaatg tttttggaaa tatctttaac actggtaatc 3000 ttggtcaaaa gtctagtaaa acgattcaag atgtacccgt tgaaattctt tataacacta 3060 aagatttgca tttaacaaaa gcgcctgaaa cagttaatgt gactatttca ggaccacaat 3120 caaagataat aaaaattgaa aatccagaag atttaagagt agtgattgat ttatcaaatg 3180 ctaaagctgg aaaatatcaa gagaagtatc aagttaaagg gttagctgat gacattcatt 3240 attctgtaaa acctaaatta gcaaatatta cgcttgaaaa caaagtaact aaaaagatga 3300 cagttcaacc tgatgtaagt cagagtgata ttgatccact ttataaaatt acaaagcaag 3360 aagtttcacc acaaacagtt aaagtaacag gtggagaaga acaattgaat gatatcgctt 3420 atttaaaagc cacttttaaa actaataaaa agattaatgg tgacacaaaa gatgtcgcag 3480 aagtaacggc ttttgataaa aaactgaata aattaaatgt atcgattcaa cctaatgaag 3540 tgaatttaca agttaaagta gagcctttta gcaaaaaggt taaagtaaat gttaaacaga 3600 aaggtagttt agcagatgat aaagagttaa gttcgattga tttagaagat aaagaaattg 3660 aaatcttcgg tagtcgagat gacttacaaa atataagcga agttgatgca gaagtagatt 3720 tagatggtat ttcagaatca actgaaaaga ctgtaaaaat caatttacca gaacatgtca 3780 ctaaagcaca accaagtgaa acgaaggctt atataaatgt aaaataaata gctaaattaa 3840 aggagagtaa acaatgggaa aatattttgg tacagacgga gtaagaggtg tcgcaaacca 3900 agaactaaca cctgaattgg catttaaatt aggaagatac ggtggctatg ttctagcaca 3960 taataaaggt gaaaaacacc cacgtgtact tgtaggtcgc gatactagag tttcaggtga 4020 aatgttagaa tcagcattaa tagctggttt gatttcaatt ggtgcagaag tgatgcgatt 4080 aggtattatt tcaacaccag gtgttgcata tttaacacgc gatatgggtg cagagttagg 4140 tgtaatgatt tcagcctctc ataatccagt tgcagataat ggtattaaat tctttggatc 4200 agatggtttt aaactatcag atgaacaaga aaatgaaatt gaagcattat tggatcaaga 4260 aaacccagaa ttaccaagac cagttggcaa tgatattgta cattattcag attactttga 4320 aggggcacaa aaatatttga gctatttaaa atcaacagta gatgttaact ttgaaggttt 4380 gaaaattgct ttagatggtg caaatggttc aacatcatca ctagcgccat tcttatttgg 4440 tgacttagaa gcagatactg aaacaattgg atgtagtcct gatggatata atatcaatga 4500 gaaatgtggc tctacacatc ctgaaaaatt agctgaaaaa gtagttgaaa ctgaaagtga 4560 ttttgggtta gcatttgacg gcgatggaga cagaatcata gcagtagatg agaatggtca 4620 aatcgttgac ggtgaccaaa ttatgtttat tattggtcaa gaaatgcata aaaatcaaga 4680 attgaataat gacatgattg tttctactgt tatgagtaat ttaggttttt acaaagcgct 4740 tgaacaagaa ggaattaaat ctaataaaac taaagttggc gacagatatg tagtagaaga 4800 aatgcgtcgc ggtaattata acttaggtgg agaacaatct ggacatatcg ttatgatgga 4860 ttacaataca actggtgatg gtttattaac tggtattcaa ttagcttctg taataaaaat 4920 gactggtaaa tcactaagtg aattagctgg acaaatgaaa aaatatccac aatcattaat 4980 taacgtacgc gtaacagata aatatcgtgt tgaagaaaat gttgacgtta aagaagttat 5040 gactaaagta gaagtagaaa tgaatggaga aggtcgaatt ttagtaagac cttctggaac 5100 agaaccatta gttcgtgtca tggttgaagc agcaactgat gaagatgctg aaagatttgc 5160 acaacaaata gctgatgtgg ttcaagataa aatgggatta gataaataaa tactgtatta 5220 caaatgagcc gatgcgtatg catcggtttt ttgtgtttgt agaaataatt tatagtacaa 5280 acgtaaaatg atataaacaa aataaaaaca aagtaatcaa tatgtaatat aaaatacact 5340 ggtactcaat atataatgat gataaaatta attttaatta gatagagttg ctttgtgttt 5400 ttaacgcaga tgctactact tatcttaaca gttgattaag tgaaatcatt taacagcgag 5460 aataatcaac caggaggatg acttaatgaa tttattcaga caacaaaaat ttagtatcag 5520 aaaatttaat gtcggtattt tttcagcttt aattgccact gttactttta tatctactaa 5580 cccgacaaca gcgtctgcag cagagcaaaa tcagcctgca caaaatcaac cagcacaacc 5640 agctgatgcc aatacacagc ctaacgcaaa tgctggtgct caagctaatc ctacagcaca 5700 gccagctgca cctgccaacc aaggacaacc agcagtacaa ccagcaaacc aaggtggaca 5760 ggctaatcca gcaggaggag cagcacaacc aaatacacaa ccagctggac aaggtaatca 5820 agctgatccg aataacgctg cacaagcaca acctggaaat caagcaacac cggcaaacca 5880 agcaggtcaa ggaaataacc aagcaacacc taataataat gcaacaccgg caaatcaaac 5940 acagccagcg aatgctccag cagcagcgca accagcagca cctgtagcag caaacgcaca 6000 aactcaagat ccaaatgcta gcaatactgg tgaaggcagt attaatacga cattaacatt 6060 tgatgatcct gccatatcaa cagatgagaa tagacaggat ccaactgtaa ctgttacaga 6120 taaagtaaat ggttattcat taattaacaa cggtaagatt ggtttcgtta actcagaatt 6180 aagacgaagc gatatgtttg ataagaataa ccctcaaaac tatcaagcta aaggaaacgt 6240 ggctgcatta ggtcgtgtga atgcaaatga ttctacagat catggtaact ttaacggtat 6300 ttcaaaaact gtaaatgtaa aaccagattc agaattaatt attaacttta ctactatgca 6360 aacgaatagt aagcaaggtg caacaaattt agttattaaa gatgctaaga aaaatactga 6420 attagcaact gtaaatgttg ctaagactgg tactgcacat ttatttaaag taccaactga 6480 tgctgatcgt ttagatttac aatttattcc tgacaataca gcagttgctg atgcttcaag 6540 aattacaaca aataaagatg gttataaata ctattcattc attgataatg taggtctatt 6600 ctcaggatca catttatatg tcaaaaatag agatttagca ccgaaagcaa ctaacaataa 6660 agaatatact attaatactg aaatcggtaa caatggtaat tttggtgctt cattaaaagc 6720 agatcaattt aaatatgaag taacattacc acaaggtgta acttacgtta ataattcatt 6780 aactacaaca ttccctaatg gtaatgaaga cagtacagta ttgaaaaata tgactgttaa 6840 ttatgatcaa aatgcaaata aagttacatt tacaagccaa ggtgtgacaa cggcacgtgg 6900 tacacacact aaagaagttt tattcccaga taaatcttta aaattatcat ataaagttaa 6960 tgttgcgaat atcgatacac ctaaaaatat tgattttaat gaaaaattaa catatcgtac 7020 tgcttcagat gttgtaatta ataatgcgca accagaagtt acactaactg cagatccatt 7080 ttcagtagcg gttgaaatga acaaagatgc gttgcaacaa caagtaaact cacaagttga 7140 taatagtcat tacacaacag catcaattgc agaatacaat aaacttaaac aacaagcaga 7200 tactatttta aatgaagatg cgaatcatgt taaaactgca aatcgtgcat ctcaagcgga 7260 tattgatggt ttagtaacta aattacaagc tgcattaatt gataatcaag cagcaattgc 7320 tgaattagat actaaagctc aagaaaaggt tacagcagca caacaaagta aaaaagttac 7380 gcaagatgaa gttgcagcac ttgtaactaa aattaacaat gataaaaata atgcaatcgc 7440 agaaattaat aaacaaacta cagcacaagg tgtcacaact gaaaaagata atggtatcgc 7500 agtgttagaa caagatgtga ttacaccaac agttaaacct caagcgaaac aagatattat 7560 ccaagcagtt acaactcgta aacaacaaat taaaaagtca aatgcatcat tacaagatga 7620 aaaagatgta gcaaatgata aaattggtaa aattgaaaca aaggcaatta aagatattga 7680 tgcagcaaca acaaatgcac aagtagaagc cattaaaaca aaagcaatca atgatattaa 7740 tcaaactaca cctgctacaa cagctaaagc agcagctctt gaagaatttg acgaagttgt 7800 tcaagcacaa attgatcaag cacctttaaa tcctgataca acaaatgaag aagtagcgga 7860 agctattgaa cgtattaatg cagctaaagt ttctggtgtt aaagcaattg aagcgacaac 7920 gactgcacaa gatttagaaa gagttaaaaa cgaagaaatc tcaaaaattg aaaatattac 7980 tgactctacg caaacaaaaa tggatgccta taatgaagtt aaacaagctg caacagctag 8040 aaaagctcaa aatgctacag tttcaaatgc aacaaatgaa gaagtagcag aagctgatgc 8100 agcagtagat gcagctcaaa agcaaggttt acatgacatc caagttgtta aatcaaaaca 8160 ggaagttgct gatacaaaat caaaagtatt agataaaatc aatgcaattc aaacacaagc 8220 aaaagttaaa cctgcagctg atacggaagt agaaaacgca tataatacac gtaaacaaga 8280 aattcaaaat agcaatgctt caactacaga agaaaaacaa gctgcatata cagaattaga 8340 tactaaaaag caagaagcaa gaacaaatct tgatgctgca aatacaaaca gtgatgtaac 8400 aacagctaaa gacaatagta ttgctgcaat taatcaagtt caagctgcca caactaagaa 8460 atcggatgca aaagcggaaa tcgctcaaaa agcaagtgaa cgtaaaacag caattgaagc 8520 aatgaatgat tcgactactg aagaacaaca agcagcgaaa gacaaagtgg atcaagcagt 8580 agttactgca aacgctgata tagataatgc tgcagcaaac aatgatgtgg ataatgcaaa 8640 aactacaaat gaagctacaa tcgcagccat tacacctgat gcaaatgtta aaccagcagc 8700 aaaacaagca attgcagata aagtacaagc tcaagaaaca gcaattgatg gaaataacgg 8760 ctcaacaact gaagaaaaag cagctgctaa acaacaagtt caaactgaaa aaacaacagc 8820 tgatgccgca atagatgcag cacatacaaa tgcggaagtt gaagcggcta aaaaagcagc 8880 aattgctaaa attgaagcga ttcagccagc aacaacaact aaagataatg cgaaagaagc 8940 aattgctacg aaagcgaatg aacgtaaaac agcaatcgct caaacgcaag acattactgc 9000 tgaagaaatt gcagcggcta atgcggacgt agataatgct gtgacacaag caaatagcaa 9060 cattgaagct gctaatagtc aaaatgatgt agaccaagcg aaaacgacag gtgaaaatag 9120 tattgatcaa gtaacaccaa cagttaataa aaaagcaact gcacgtaatg aaatcacagc 9180 aattttaaat aacaaattgc aagagattca agctacgcca gatgcaacag atgaagaaaa 9240 acaagcagct gatgctgaag caaatactga aaatggtaaa gcaaatcaag ccatttcagc 9300 agcaactact aacgcacaag ttgatgaagc taaagcaaat gcagaagcag cgattaatgc 9360 ggtaacacca aaagttgtga agaaacaagc ggctaaagat gaaattgatc aattacaagc 9420 aacgcaaaca aatgttatca ataatgatca gaacgctaca acagaagaaa aagaagcagc 9480 tattcaacaa ttagcaacag cagttacaga cgcgaaaaat aatattacag ctgcaactga 9540 tgataatggt gtagatcagg cgaaagacgc tggaaagaat tcaattcaaa gcacgcaacc 9600 agcaacagcg gttaaatcaa atgctaaaaa tgatgttgat caagctgtga caactcaaaa 9660 tcaagcaatt gataatacaa ctggtgctac aactgaagag aaaaatgcag caaaagattt 9720 agttttaaaa gctaaagaaa aagcgtatca agatatctta aatgcacaaa caactaatga 9780 tgttacgcaa attaaagatc aagcagttgc tgatattcaa ggtattactg cagatacaac 9840 aattaaagat gttgcgaaag atgaattagc aacaaaagca aacgaacaaa aagcgcttat 9900 tgcacaaact gcagatgcga ctactgaaga aaaagaacaa gcaaatcaac aagtagacgc 9960 acaattaaca caaggtaatc aaaatattga aaatgcacag tcaatcgatg atgtaaacac 10020 tgcaaaagat aatgcaattc aagcaattga cccaattcaa gcatcaacag atgttaaaac 10080 gaatgcaaga gcggaattgc taactgaaat gcaaaataaa ataactgaaa tacttaataa 10140 taatgagact actaatgaag aaaaaggtaa cgatattgga ccagttagag cagcatatga 10200 agaaggttta aataatatta atgcagcaac tactacaggt gatgtaacta ctgctaaaga 10260 tacagcagta caaaaagttc aacaacttca tgcaaatcct gttaagaaac cagcaggtaa 10320 aaaagaatta gatcaagctg cagctgataa gaaaacacaa atagaacaaa caccaaatgc 10380 atcacaacaa gaaattaatg atgcaaaaca agaagttgat actgaattaa atcaagcgaa 10440 aacaaatgtc gatcaatcat caacaaatga atatgttgat aatgcagtta aagaaggaaa 10500 agctaaaatt aatgcagtta aaacatttag tgagtacaaa aaagatgctt tagctaaaat 10560 tgaagatgca tataatgcta aagtaaacga agcggataac tctaacgcat cgacttcaag 10620 tgaaattgct gaagcgaaac aaaaacttgc tgaattaaaa caaactgcgg atcaaaatgt 10680 taatcaagct acttctaaag atgacattga agttcaaatt cataatgact tagataatat 10740 taacgattac acaattccaa caggtaaaaa agaatcagct acaacagatt tatatgctta 10800 tgcagatcag aagaaaaata atatttcagc tgacactaat gcaacacaag atgaaaagca 10860 acaagcaatt aagcaagttg accaaaatgt tcaaactgca ttagaaagca ttaataatgg 10920 tgtggataat ggtgacgttg atgatgcatt aacacaaggt aaagcagcaa ttgatgctat 10980 tcaagtagat gctactgtta aacctaaagc gaaccaagct attgaagtta aagcagaaga 11040 tacgaaagaa tctattgatc aaagtgacca gttaactgct gaagaaaaaa ctgaagcatt 11100 agcaatgatt aaacaaatta cagatcaagc taaacaaggt attactgatg caacaacaac 11160 tgctgaagtt gaaaaagcga aagctcaagg acttgaagca tttgataaca ttcaaatcga 11220 ctcaacagaa aaacaaaaag ctatcgaaga attagaaact gcactagacc agattgaagc 11280 aggtgtaaat gtcaacgctg atgctacaac tgaagaaaaa gaagcgttta cgaatgcttt 11340 agaagacatt ttatcaaaag caactgaaga tatttctgat caaactacaa atgcagaaat 11400 cgctactgtc aaaaatagtg cgcttgaaca acttaaagca caacgtatta atcctgaagt 11460 taagaaaaat gctttggaag caatcagaga agtggttaac aagcaaatag aaataattaa 11520 aaatgcagat gcagatgcat cggcgaaaga aattgcacgt acggatttag gtagatattt 11580 tgacagattt gctgataaat tagataaaac acaaacaaat gcagaagttg ctgaattaca 11640 aaatgtaacg atacctgcaa ttgaagcgat tgtgcctcag aatgatccag atgctaatga 11700 tactaataat ggtatagata ataatgatgc aacagcaaat tcaaatgcta atgcaacacc 11760 agaaaatact ggacaaccta acgtatctga gacgacagct aatggcaaag cagacgcttc 11820 tccgacaaca ccaaataata gtgatgcggc aacaggtgaa acaacagcaa catcagcaac 11880 tgatgatgca aatgataaac cgcaagctaa taacaattct agtgtagatg catcaacaaa 11940 cagtccgaca atggataacg atgtaactag taaaccagaa gtagaatcaa ctaataacgg 12000 cacaactgat aaacctgtaa cagaaactga taatgcaacg ccagcagaaa gcacaacaaa 12060 taacaatagt acaactacag caacaaacga gaatgcacca acaggatcaa cagcaacggc 12120 tccaacaact gcgagcacag aagcagcatc atctgctgat agcaaagata atgcatctgt 12180 aaatgattca aaacaaaatg ctgaagtaaa taatagtgct gaatctcaat caactaatga 12240 caaggttgca caaccaaaat ctgaaaataa agctaaggca gaaaaagatg gtagtgattc 12300 aacaaatcaa agtatggttg aatcaacaac tgaaacattg ccttcagcag acataacaga 12360 accaaatgta ccttctaata catcaaaaga taaagaagaa agtacgacaa atcaaactga 12420 tgcaggacaa cttaagtctg aaactaacgt tgcatctaac gaagcagata aatcgccaag 12480 caaagctgat actgaagttt cgaataaacc atcaacatct gcatcttctg aagcaaaaga 12540 aaaaatgact tcaactaatc ttagccaaaa agatgatacg gcaacagcag atactaatga 12600 tacgcaaaaa tcagttggtt cagctgcaaa caataaagct acgcaaaacg acggtgccaa 12660 tgcatctcca gctacagttt caaatggaag caatagtgct aatcaagata tgcttaatgt 12720 aactaacact gacgaccacc aagctaagac aaaatcagct caacaaggaa aagttaataa 12780 agctaaacaa caagctaaaa ctttaccaga tactggtatg tcacataatg acgatttacc 12840 atatgctgaa ttagctctag gtgcaggtat ggcattctta attagaagat tcactaagaa 12900 agaccaacaa actgaagaat aaaatttatt caagaatgtg aacatctagt tatttcatag 12960 ggaaatattc cttactaagt aaccaagtct aacagttaat atgaatttgt tttagtaatg 13020 accaatagcc attgaatagg tggctgtggc tcgaaaataa aacaaattat taacgcaaaa 13080 atactccttt catacataac acaagttaag tgtctatgtt gaagggagta ttttttatgt 13140 tcagaaattt aatattgtta attcaaggga actactacat tattactgat tgttaacgaa 13200 taacgttgga aacttcttgt ttcaaacaaa gctcaataaa ttatgaaagt gaattgtacg 13260 cttcaattat ttcatcggct aagccatcgt caactttagc atattcactt aaaaacgctt 13320 ttaaaccgtg ttctttaatg taattatttt tctcaacagt ttcttggtct gctgtatcat 13380 catacttcaa taacaatgca gctgtattta ataaaccagt gcgttctaaa tctttattat 13440 aaagatatgt taatggtttt ataattctat ctttagggcc aattttacgt aatgtacctc 13500 gtccgacacg tgttacttca tcagataaat aagaattgtt gaaacgatct attatttttt 13560 caacataagc agcttgttcc gcttcagtaa aatcaaattc attagtaata tattgactag 13620 tttcagctaa aacacggcgt aagccagctt caattgaact atcttcaact gcatctaaaa 13680 ctgtagcttt acctgcaaat ttaccagcat acgctaaata tgcatgtcct gtattcacag 13740 ttaataattt acgctcaata tatggtgtta aatcatcaac atatttaata tggtttagtt 13800 ctggaccata ccatgcatct ttttcaacaa cccattcgta aaatggctca accataacgt 13860 ctaatatatt ttcattcttt tgtaatggta caattctatc aactgctgag ttagcaaaat 13920 gaatattgtt accaagaggg ccagtaatat caagtactgc ttttttcaat gtatcagttg 13980 ccataatagc attctcacaa gcaacaatat taacatggtt tgttttttct tttaagaaag 14040 gcgcaaaaga tttagcaata ataggtagta tgttaacacc aacagctgtt gtaataatat 14100 cagcttctag aattgcttgt ttcaacgctt cagaaggttg cattgaatta attgcatcaa 14160 cattattcac gcgcgtcgtt gttttagact catcagctaa aataacatcg tattgatgat 14220 catgagctaa agcattaatg atttcttcat tgacgtctgc aaatgttact ttaacattgt 14280 tgtctgcaag aatataacca atgaaaccac gacctatgtt accagcacca aagtgaactg 14340 ctttcattat gcatctgcct cctcgaatac ttgtttaatt tcttctgcag attttgcttg 14400 aacgatacga tccacatttt cttcttcgct aaatgtaatt gcaattttag ataacaagtc 14460 taaatgttcg ccatctttac cagcaattcc cacgacaact ttaactactt cgccatccca 14520 gtcaacgcct tcagggattt gtaataatgt taaacctgag tgaatcacat ttgttttagc 14580 ttcatctgtg ccatgaggaa ttgctaagcc atttcccata aatgttgata cgacttgctc 14640 acgatctttc attgcttgaa tataagcatc tgttacagca ccactatcaa ctaaggcttt 14700 acctgctttt tcaattgctt cattttggct gttaacattt acatttaaaa agatattgtc 14760 attactaaat aattcgctca ttttgtacac tcctaaataa attgtttttt aattcgttct 14820 aaaaatttgt ttcttaataa tgtttcaagt tcctgtggat tttccataaa agtatcaata 14880 gattctaatt tcaaacttaa aaattcggac aagtcactta ccagtgatgc cataaaatca 14940 ttgtcagaaa taaacatgga aatcatatat ttaattgttt gattgtcatt ttgaatacta 15000 ggcaatgtta acggttcttc taaaactgtg attagaatca tagggtgttt aatcatattg 15060 tctcttaggt gtggtattgc aacaggatat ggacttaata tccatcctgg attgtcaatc 15120 aatcgttgct ctagtagttc agcgaatgac gttggatcgt ttattacatc gcattgatat 15180 agataatctg cgatatatgt ttgccactgt ttaacttcgg tactaactat tttcactgaa 15240 tcaagcaaag ttaaacccga acgcatatga tgcaataatt gttctgattt ttcgtcactt 15300 aaatgttttt 15310 // |
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