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EBI DbfetchID X99978; SV 2; linear; genomic DNA; STD; PRO; 11180 BP. XX AC X99978; XX DT 01-APR-1997 (Rel. 51, Created) DT 21-FEB-2006 (Rel. 86, Last updated, Version 10) XX DE Lactobacillus plantarum subsp. plantarum citrulline biosynthetic gene DE cluster (carAB operon and argC, J, B, D, F-ccl operon) and usg and dsg DE partial sequences XX KW acetylglutamate kinase; anabolic ornithine carbamoyltransferase; argB gene; KW argC gene; argD gene; argF gene; KW arginine-specific carbamoyl-phosphate synthase large subunit; KW arginine-specific carbamoyl-phosphate synthase small subunit; argJ gene; KW carA gene; carB gene; carbamoyl-phosphate synthetase ammonia chain; KW carbamoyl-phosphate synthetase glutamine chain; ccl gene; dsg gene; KW glutamate N-acetyltransferase; N-acetyl-gamma-glutamyl-phosphate reductase; KW usg gene. XX OS Lactobacillus plantarum subsp. plantarum OC Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus. XX RN [1] RX PUBMED; 9098069. RA Bringel F., Frey L., Boivin S., Hubert J.C.; RT "Arginine biosynthesis and regulation in Lactobacillus plantarum: the carA RT gene and the argCJBDF cluster are divergently transcribed"; RL J. Bacteriol. 179(8):2697-2706(1997). XX RN [2] RC revised by [3] RA Bringel F.; RT ; RL Submitted (12-AUG-1996) to the EMBL/GenBank/DDBJ databases. RL F. Bringel, Universite Louis-Pasteur/ CNRS, Microbiologie et Genetique, 28, RL rue Goethe, Strasbourg 67083 cedex, FRANCE XX RN [3] RP 1-11180 RA Bringel F.; RT ; RL Submitted (21-SEP-1999) to the EMBL/GenBank/DDBJ databases. RL F. Bringel, Universite Louis-Pasteur/ CNRS, Microbiologie et Genetique, 28, RL rue Goethe, Strasbourg 67083 cedex, FRANCE XX RN [4] RX DOI; 10.1128/JB.182.12.3416-3422.2000 RX PUBMED; 10852872. RA Nicoloff H., Hubert J.C., Bringel F.; RT "In Lactobacillus plantarum, carbamoyl phosphate is synthesized by two RT carbamoyl-phosphate synthetases (CPS): carbon dioxide differentiates the RT arginine-repressed from the pyrimidine-regulated CPS"; RL J. Bacteriol. 182(12):3416-3422(2000). XX RN [5] RX DOI; 10.1007/s00203-005-0774-9 RX PUBMED; 15864550. RA Nicoloff H., Hubert J.C., Bringel F.; RT "Lactobacillus plantarum ccl gene is non-essential, arginine-repressed and RT codes for a conserved protein in Firmicutes"; RL Arch. Microbiol. 183(5):307-316(2005). XX DR RFAM; RF00522; PreQ1. XX FH Key Location/Qualifiers FH FT source 1..11180 FT /organism="Lactobacillus plantarum subsp. plantarum" FT /strain="CCM 1904 equivalent to ATCC 8014" FT /mol_type="genomic DNA" FT /db_xref="taxon:337330" FT CDS <1..377 FT /codon_start=3 FT /transl_table=11 FT /gene="usg" FT /product="hypothetical protein" FT /note="upstream gene of citrulline biosynthetic cluster" FT /db_xref="UniProtKB/TrEMBL:Q9RLT0" FT /protein_id="CAB56842.1" FT /translation="ATDYLVTVKLYLGFRVRQDINRYLRTIVRDLMATGRLAAQKQTYS FT VTSGRDVGDFRFVIIEEKLENGSRLSRLDRLVIETKLMIKKYATTPAKWFGLEFSEVTL FT ETVPILFNEIPALPITERQR" FT terminator 435..459 FT /gene="usg" FT /note="rho-independent" FT /inference="non-experimental evidence, no additional FT details recorded" FT terminator complement(435..459) FT /gene="carB" FT /note="rho-independent terminator of carAB operon" FT CDS complement(484..3546) FT /transl_table=11 FT /gene="carB" FT /product="carbamoyl-phosphate synthase large subunit" FT /EC_number="6.3.5.5" FT /note="arginine specific" FT /db_xref="GOA:Q9RLS9" FT /db_xref="InterPro:IPR005479" FT /db_xref="InterPro:IPR005480" FT /db_xref="InterPro:IPR005481" FT /db_xref="InterPro:IPR005483" FT /db_xref="InterPro:IPR006275" FT /db_xref="InterPro:IPR011761" FT /db_xref="InterPro:IPR013817" FT /db_xref="InterPro:IPR016185" FT /db_xref="UniProtKB/Swiss-Prot:Q9RLS9" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAB56843.1" FT /translation="MPKNNAIHSIAVIGSGPIKIGQAAEFDYAGTQACLSLKAAGYHVI FT LINSNPATIMTDTATADEVYLEPLTLTSVTKILRATHPDALLPTLGGQTGLNLAMALDQ FT AGVLNELKIQLLGTSLATINQAEDRAAFKTLMKRLHQPIPASTTVHHVTSALSFAEKIG FT YPVIVRPAFTLGGSGGGIANNAAELTQTLQRGLTMSPVTECLIEQSIAGFKEIEFEVMR FT DNQGTKIIVCSMENFDPVGIHTGDSIVYAPVQTLTDTEYQQLRTAALTIVEALDIRGGC FT NVQLAQDPNSRQYYVIEVNPRVSRSSALASKATGYPIAKIAADIAIGLNLSEIKNPVTQ FT TTYAAFEPALDYVVAKIPRFAFDKFPTADAHLGTQMKATGEVMAIGSTLEEATLKAIAS FT LEIDPKTQASLTPDHHVTTTEYIDQLTHPTDQRLFYLLAALQAGWPLAKLATLTQITPF FT FLSKLQHIAQLIRNIKQVPTSQHLLSAKKYGVSLATMAHYAQTSVATIAAMTADLPFVY FT KMVDTCAGEFASVTPYFYSTAFGQTNESHPLGHSILVLGSGPIRIGQGIEFDYTTVHCV FT KAIQQAGYHAIIVNNNPETVSTDFSTSDKLYFEPLTIERLMPIIALEQPAGVIVQFGGQ FT TAINLAHQLTKLGVTVLGTSVSATDLTEDRQSFADCLRLLKIAQAAGTTVTELSGARQA FT AHAIGYPLLVRPSFVLGGRAMAIVHNDHELTPVIKSAVAAGHGAPILMDQYLAGTECEV FT DVLSDGTSCFIPGIMEHIEGAGVHSGDSITVYPPQHLSPAVQDKIVTIATKLAQHLHCV FT GMMNIQFVVTDDVYVIDVNPRASRTVPYMSKVTHLPLAQLATRLILGQSLATLGLVPGL FT LTPAPQQIAIKAPVFSFNKLPQSPVVLSPEMKSTGETLGIGPTFTTAWHAAMADSYHLE FT TWQTVDGLITDIATVAQPAVQELFAANHLTVTTIANTTDWPAKTKAVGFTLNDQPDNPV FT AIAALNHGQPLITAIDTLKTLLAVTPTPATI" FT CDS complement(3539..4606) FT /transl_table=11 FT /gene="carA" FT /product="carbamoyl-phosphate synthase small subunit" FT /EC_number="6.3.5.5" FT /note="arginine-specific" FT /db_xref="GOA:O08317" FT /db_xref="InterPro:IPR000991" FT /db_xref="InterPro:IPR001317" FT /db_xref="InterPro:IPR002474" FT /db_xref="InterPro:IPR006220" FT /db_xref="InterPro:IPR006274" FT /db_xref="InterPro:IPR011702" FT /db_xref="InterPro:IPR017926" FT /db_xref="UniProtKB/Swiss-Prot:O08317" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA68238.2" FT /translation="MNKYLTLADGTQWIGTAIGDCQLEVAGRIVFNTGMTGYQETLTDP FT SYLNQMIAFTYPLIGNYGIDPTVAQAPTIGAQAIIVHELTTFNDHYTSRQSLASFLTIH FT HVAGIEGVDTRDLTIHIRQTGAQMAILSNHPITDFEAQLATFAPQVLTATPLPVATTTI FT RPRVAILNFGEKAAITAELQARGADVVVLPPTASLKAVAAYHPDGILLSNGPGDPTDYH FT TYLATIRQLAQRYPLAGICLGHQLIALAYGAQTYQLSFGHHGLNHPVQACADGRIIMTS FT QNHDYAVDPASIKGTPLIVTHTELNDGSIEGLRLPHQAVMSVQFHPEAHPGPQEAGQFF FT DDFLLTIQKEAVVNA" FT misc_feature complement(4590..4607) FT /note="Escherichia coli like Arg box termed R11" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature complement(4639..4656) FT /note="Bacillus subtilis like Arg box" FT /inference="non-experimental evidence, no additional FT details recorded" FT promoter complement(4662..4690) FT /gene="carA" FT /note="promoter of arginine-repressed carAB operon" FT /experiment="experimental evidence, no additional details FT recorded" FT misc_feature 4679..4696 FT /note="Escherichia coli like Arg box termed R1" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature complement(4679..4696) FT /note="Escherichia coli like Arg box termed R10" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature 4719..4736 FT /note="Escherichia coli like Arg box termed R2" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature 4757..4774 FT /note="Escherichia coli like Arg box termed R3" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature complement(4757..4774) FT /note="Escherichia coli like Arg box termed R9 and Bacillus FT subtilis like arg box" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature 4768..4785 FT /note="Escherichia coli like Arg box termed R4" FT /inference="non-experimental evidence, no additional FT details recorded" FT promoter 4780..4808 FT /gene="argC" FT /note="promoter of arginine-repressed argCJBDF-ccl operon" FT /experiment="experimental evidence, no additional details FT recorded" FT misc_feature 4797..4814 FT /note="Escherichia coli like Arg box termed R5" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature 4825..4848 FT /note="Escherichia coli like Arg box termed R6" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature 4852..4869 FT /note="Escherichia coli like Arg box termed R7" FT /inference="non-experimental evidence, no additional FT details recorded" FT misc_feature complement(4808..4829) FT /note="Escherichia coli like Arg box termed R8" FT /inference="non-experimental evidence, no additional FT details recorded" FT CDS 4874..5899 FT /transl_table=11 FT /gene="argC" FT /product="N-acetyl-gamma-glutamyl-phosphate reductase" FT /EC_number="1.2.1.38" FT /db_xref="GOA:O08318" FT /db_xref="InterPro:IPR000534" FT /db_xref="InterPro:IPR000706" FT /db_xref="InterPro:IPR012280" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/Swiss-Prot:O08318" FT /protein_id="CAA68239.1" FT /translation="MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTV FT AAMYQKETAVIRPFDATAIMRDNAIVFFATSAGITRQLALPFIAAHFPVIDLSGDFRLH FT DPEQYQRWYQRDPAPATALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQQQL FT VEPTSIVVDAKSGLSGAGKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAI FT SAIEFTTTLIPATRGIMTTIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKD FT VVGSNNCALGVDYNPVTNTIVVVSVIDNLMKGAAGQAVQNFNRYFDFAVTAGLPTLPVF FT P" FT CDS 5924..7138 FT /transl_table=11 FT /gene="argJ" FT /product="glutamate N-acetyltransferase" FT /EC_number="2.3.1.35" FT /db_xref="GOA:O08319" FT /db_xref="InterPro:IPR002813" FT /db_xref="InterPro:IPR016117" FT /db_xref="UniProtKB/Swiss-Prot:O08319" FT /protein_id="CAA68240.1" FT /translation="MQMQVLTNTKFETVAFQWPAGFYSDGIHIGLRRHKKDFGWLFSKV FT PASAAGTYTTNQFQAAPTKLTKQMIDQGHQLQGLLLNSAIANSCTGEQGWQNALQEQAW FT LANKLNVAPNLIGVASTGLIGAQLPMDKIKNGLPQLTPTKSDAVTYAVLTTDQHPKTVC FT VQCELSGQLVTLTGFAKGSGMIHPKMATMLGFVTTDAQIDGPVLQDMLSTNVDQTFNQI FT TVDGDTSTNDMVVTLANGLADNPSLQAGTTDYDIFNQALHYVLGQLAKQIAADGEGATK FT LVECNVVHAATTFDGQQIAKAIVGSNLVKAAIFGEDPNWGRIISTIGATDADIDVATVD FT IEMNGVLLVQQSLAVDFDMAAVQATLRDNQIMIDVDLHHGTASGQAWGCDLTYNYVKIN FT ASYHT" FT CDS 7154..7900 FT /transl_table=11 FT /gene="argB" FT /product="acetylglutamate kinase" FT /EC_number="2.7.2.8" FT /db_xref="GOA:O08320" FT /db_xref="InterPro:IPR001048" FT /db_xref="InterPro:IPR004662" FT /db_xref="InterPro:IPR011148" FT /db_xref="UniProtKB/Swiss-Prot:O08320" FT /protein_id="CAA68241.1" FT /translation="MTKLIVIKIGGQAISQLSTTFFDQIAQWYQQQYQILIVHGGGPMI FT NRLTTQLALPVHKVNGLRVTDAATLVLTKLALLGDAQPALLAKLTQHHLPVLGLNAADN FT QLLTGELIDYRQLGYVGRLTAVNQVQLMQLLAHHIGILAPLALTETGQWLNVNADMAAT FT VLAQQLHAEKLVLLTDVPGIIHHGNVMTSLSPQQAQQLIRTAVITAGMQPKVQAAIAAI FT QTGVKQAIITNAIDQPGTAIIQEVAV" FT CDS 7897..9066 FT /transl_table=11 FT /gene="argD" FT /product="acetylornithine aminotransferase" FT /EC_number="2.6.1.11" FT /db_xref="GOA:O08321" FT /db_xref="InterPro:IPR004636" FT /db_xref="InterPro:IPR005814" FT /db_xref="InterPro:IPR015421" FT /db_xref="InterPro:IPR015424" FT /db_xref="UniProtKB/Swiss-Prot:O08321" FT /protein_id="CAA68242.1" FT /translation="MTMQHVFPTYQRFPFAITDGQGVHLTDNHGKTYLDFTAGIGVCNF FT GYHQPQIQAAVTQQLTHIWHTSNLYENELQDAVAGLLANGEERLVYFANSGTEANEAAL FT KLARKYTGKTGILAFQHSFHGRTYGAMSMTGNPHIQAGYAPLVPGITFATYNDDAALDK FT ITPELAAVILEVVQGEGGVFAGQTAWLQAVNAKCQATGVLLIIDEVQTGIGRTGYRMAY FT EGYGLDPDIYTVAKGLANGLPVGAMVGRRQLATAFGPGSHGSTFAGNAVAMAAAKRVLT FT QLTPALLTTVRAHAKLVWQSLATQVEPIPVVKQITGKGLMIGIHLDEQIPVNQVITRLQ FT VEGLLTLSAGDNTLRLLPPIVMQPADLLAGIALIAKVLTTLTTEVTTNE" FT CDS 9059..10081 FT /transl_table=11 FT /gene="argF" FT /product="anabolic ornithine carbamoyltransferase" FT /EC_number="2.1.3.3" FT /db_xref="GOA:O08322" FT /db_xref="InterPro:IPR002292" FT /db_xref="InterPro:IPR006130" FT /db_xref="InterPro:IPR006131" FT /db_xref="InterPro:IPR006132" FT /db_xref="UniProtKB/Swiss-Prot:O08322" FT /protein_id="CAA68243.1" FT /translation="MNNQFEGRSFLKEIDYTPTELAYLIDFASHLKTLKAHHIPHPYLQ FT GKNIALLFEKTSTRTRSAFTVAANDLGANPEFLGKDDIQFGTKESVVDTAKVLGSMYDG FT IEFRGFKQSTVEDLATYSGVPVWNGLTDEWHPTQILADFLTLKEHFGHLKGLTLAYVGD FT GRNNMANSLLVAGAMLGINIAIGAPVALQPAPAVVALAQQYAQAAGSTVVITADPQQAV FT TQADALYTDVWVSMGEQVDYGERIKQLLPFQINTTLLAATGKSSTIVMHCLPALHDLKT FT QLGAKLGEQYGMTAFEITDDVFQSKQAVVFEEAGNRMPAIKAVMAATLGNLFIPTSIFN FT " FT terminator complement(10945..10965) FT /gene="dsg" FT /note="rho-independent" FT /inference="non-experimental evidence, no additional FT details recorded" FT promoter 10087..10110 FT /gene="ccl" FT /experiment="experimental evidence, no additional details FT recorded" FT CDS 10190..10696 FT /transl_table=11 FT /gene="ccl" FT /function="not essential gene which encodes for a putative FT hydrophobic protein" FT /note="citrulline cluster-linked gene" FT /db_xref="InterPro:IPR010387" FT /db_xref="UniProtKB/TrEMBL:O05109" FT /protein_id="CAA68244.1" FT /translation="MTQSKIRPWIINALVAAMYVVLCLGPAAFSLASGAIQFRVSEGLN FT HLAVFNRKYIWGIVAGVILFDAFGPGASLLNVLFGGGQSLLALLVLTWLAPKLKTVWQR FT MLLNIALFTVSMFMIALMITMMSSGVAFWPTYLTTALSELIIMSITAPIMYSLDRVLHF FT SDRIQ" FT terminator 10727..10769 FT /gene="ccl" FT /note="rho-independent terminator of argCJBDF-ccl operon FT and ccl gene" FT CDS complement(10974..>11180) FT /codon_start=1 FT /transl_table=11 FT /gene="dsg" FT /note="provisonal name for downstream gene of citrulline FT biosynthetic cluster" FT /db_xref="UniProtKB/TrEMBL:O05110" FT /protein_id="CAA68245.1" FT /translation="DLAAMAKIITKYTSIAGCLTLDVQNGTLGYRTLFTLPENVDSEKL FT KRIIDNLNRKQFKVIEVEDLQAE" FT CDS complement(10297..10629) FT /transl_table=11 FT /note="function unknown and CDS within ccl gene" FT /db_xref="UniProtKB/TrEMBL:Q9RLS8" FT /protein_id="CAB56844.1" FT /translation="MIINSDKAVVRYVGQKATPLLIMVIISAIINIETVNSAIFSNIRC FT QTVFNLGANHVNTSRANNDWPPPKRTLRRLAPGPKASNKITPATIPQIYLRLNTAKWFN FT PSETRN" XX SQ Sequence 11180 BP; 2856 A; 2447 C; 2923 G; 2954 T; 0 other; tagcaacgga ctatttggta actgttaagt tatacctggg ctttcgtgtc cgccaagata 60 ttaaccgcta tttacggacg attgtccgcg acttaatggc tactggacgt ttagcggcgc 120 aaaagcagac atattcagtc acttctggcc gcgatgtcgg tgacttccgc ttcgttatca 180 tcgaggagaa gttagaaaat ggtagtcggt tatcccgctt ggatcgatta gtgatcgaga 240 cgaaattaat gattaaaaaa tacgcgacaa cgcctgccaa atggttcggc ctagaattct 300 ccgaggtgac tcttgaaacc gttccaattc tattcaacga gatcccggcg ttaccgatca 360 ctgaaagaca acgttaacga cattatcagt atttggagat ttcgctcaaa tgaaatggct 420 aaggccaaaa taaagcacct atcgaaaatt gataggtgct ttattttagt gctgccaaac 480 aagttagatg gtagctgggg ttggtgttac tgctaataat gtttttaagg tatcaatcgc 540 cgtaatcaat ggttgtccat gattcaatgc agcgatagcc acgggattgt caggttggtc 600 attaagcgtg aaacccactg ctttagtctt tgcaggccaa tcagtcgtgt tagcgattgt 660 tgtgacggtg aggtggttag ccgcgaacag ttcctggacc gcgggttgcg ccacagtggc 720 aatatcggtg atgagaccat ccacggtttg ccaagtctct aagtgataac tatcagccat 780 ggcggcatgc caagcggtcg tgaaagtcgg gccgatacca agagtctcac cagttgattt 840 catctcagga cttaaaacga ctggtgattg tggcaattta ttgaaagaga agactggggc 900 ctttatagca atttgttgtg gagcgggtgt caagagtccg gggactaggc caagggttgc 960 taaactttga ccgagaatta gccgggttgc caattgtgcc agtggcaagt gagtaacctt 1020 gctcatgtaa ggaactgttc gacttgcccg cggattaacg tcgattacgt agacatcatc 1080 ggtgacgacg aactgaatgt tcatcatacc gacacagtgg aggtgttgtg ctaatttggt 1140 ggcaatggtg acgatcttat cttgaacagc agggctgagg tgctgtggtg gatagactgt 1200 aatggaatcg ccagaatgaa cgccagcacc ttcaatatgt tccatgattc ctggaatgaa 1260 gcacgacgtt ccgtcggaga gaacgtcaac ttcacactcg gttcccgcca agtattggtc 1320 cattaagata ggcgcaccat ggccagctgc caccgctgat ttaataactg gcgtgagctc 1380 atgatcgtta tgaacgattg ccatggcccg gccgccgagt acaaagcttg gccgtacgag 1440 taaggggtaa ccgattgcgt gagctgcttg acgggcaccg gataactcag ttacggtcgt 1500 tccagcggct tgggcaatct ttagtagacg taaacagtcc gcaaaagatt gccggtcttc 1560 ggtcaaatcg gtagcggaca cactggttcc taggacggtg actcctaatt tagtgagctg 1620 atgggcaagg ttgatcgcag tttggccccc aaattgaacg atgacgcccg cgggttgctc 1680 caacgcaatg attggcatca aacgttcgat tgttagtggc tcgaaataaa gcttatccga 1740 ggtagaaaag tcggtggaga ccgtctcggg attgttattg acgatgattg catggtagcc 1800 agcttgttga atggccttga cacagtgaac ggtggtgtag tcgaattcga tgccttgtcc 1860 gattcgaatg gggcctgatc cgagtactaa aatactgtgt cctagtgggt gactctcgtt 1920 agtttgtcca aaagcagtgc tgtaaaaata tggtgtaaca ctggcaaatt caccagcaca 1980 cgtatcgacc attttataaa cgaagggtaa atcagcagtc atggcagcaa tggtcgctac 2040 cgaagtttgg gcataatgcg ccatggtcgc cagactcaca ccgtactttt tcgccgataa 2100 gaggtgttgg gacgtcggca cttgcttgat attccggatg agttgggcga tgtgctgtaa 2160 cttactcaag aaaaatggcg tgatttgcgt tagcgtcgct aattttgcta acggccaacc 2220 cgcttgcagc gccgccaata gatagaagag ccgctgatct gtcgggtggg tcaattggtc 2280 gatatattca gtcgtggtga cgtggtggtc aggggtcaag gacgcttggg tcttgggatc 2340 gatttcaagc gaagcaatcg ccttgagcgt ggcttcctcc aaggttgacc caatcgccat 2400 gacctccccc gtggctttca tctgtgttcc caagtgagcg tcggccgttg gaaacttgtc 2460 aaacgcaaac cgggggattt tggcaaccac atagtctaaa gctggttcaa aggccgcgta 2520 ggttgtctgc gtgactggat tcttgatctc agataaattt agaccaattg cgatatcggc 2580 tgcaattttg gcaattggat atcccgtcgc tttagaagct agcgccgatg aacgactgac 2640 ccgcgggttc acttcgatga cgtagtactg acgactattc gggtcttgag cgagttgaac 2700 gttgcaccca cctctaatgt cgagggcttc cacaatcgtc aaagccgccg ttcgtagctg 2760 ctgatattca gtgtcagtca aagtctgaac gggggcatac acgatagaat cgccagtgtg 2820 aataccgacc ggatcgaagt tttccatgga acagacgatg atcttggtac cctgattatc 2880 acgcatgact tcgaattcaa tttctttgaa gccggcgata ctttgttcaa tcaggcactc 2940 ggtgacgggg gacatggtca gcccccgctg taacgtttgg gtcaattcgg cggcattatt 3000 ggcaatgcca ccacctgaac ccccgagtgt aaaggctgga cgaacaatga ccggataacc 3060 gattttttca gcaaacgaca atgcactggt cacgtggtga acagtggtac ttgctggaat 3120 cggttgatgg agccgcttca taagtgtttt aaatgctgcc cggtcttcag cttgattgat 3180 ggtggctagg gaagttccta gcagttggat cttcaactca ttaagaacgc cagcctgatc 3240 taacgccatc gctaggttca atccggtttg tccaccaagt gtcgggagca aagcatcagg 3300 gtgggtggcc cgcagaattt tagtgacact ggtcaaagtc agaggttcta agtagacttc 3360 gtcggcggtg gccgtgtcag tcatgatggt tgctgggttt gaattgatca aaatgacatg 3420 atagccggcc gctttaaggc ttagacaagc ctgagtaccg gcatagtcga actcagcggc 3480 ttgaccgatt ttgattggac cagaaccgat gacagcaatc gaatgaatgg cattgttttt 3540 aggcattaac aaccgcctcc ttttgaattg ttagtaagaa atcatcgaaa aattgcccag 3600 cttcctgggg tcccgggtgt gcttcgggat ggaattgcac cgacattacg gcctggtgcg 3660 gtaggcgcaa gccttcaatg ctgccgtcat ttaattcagt gtgcgtgacg atcagcgggg 3720 tgcccttgat cgatgccgga tcgacggcgt aatcatgatt ttgcgaagtc atgataatac 3780 gaccgtcagc gcaggcttgt accggatggt ttagcccgtg gtgaccaaag gaaagctggt 3840 aagtctgagc accataggcg agcgcaatca actgatgacc aaggcaaatg ccagccagcg 3900 gataacgttg tgcgagttgg cgaatggtcg ctaagtaagt gtgatagtcg gtcggatcac 3960 cgggaccgtt ggataacaaa attccgtcag ggtgatacgc ggccacggcc ttgagactag 4020 ctgtaggtgg aaggacaaca acgtccgcgc cccgggcttg caattcagcg gtgatagctg 4080 ctttttcacc aaagttgaga atcgcgacgc gtggacggat ggtggtcgtc gctactggga 4140 ggggggtagc cgttagtact tggggtgcga atgtggcgag ttgcgcttca aaatcagtga 4200 tgggatgatt gctcaagatt gccatctggg ctcccgtttg gcgaatgtga atcgttaggt 4260 cacgagtatc gacgccttca atgccggcta catggtggat tgtcagaaaa cttgccagtg 4320 attggcgact agtatagtga tcattaaaag tggtcagctc gtgaacgatg atggcttgtg 4380 cgccaatcgt tggtgcctgg gccacggtcg gatcgatacc ataattacca attaatgggt 4440 aagtgaaggc aatcatttga tttaggtagg atggatcagt caatgtttcc tgataacccg 4500 tcattcccgt attgaagacg atgcgccccg caacctctag ctggcaatcc ccaattgccg 4560 ttccaatcca ctgtgtgccg tccgctaaag ttaagtattt gttcatccca atcgcacctt 4620 tctgataatt tggttaaaat ttcattttgg ttaatgggat aagtaaacat cattttattg 4680 tgaatgtcaa ttaaaaatac atattaagtg cataaataac tgaataaagc taaaaatatg 4740 caattaatag aataaaagtg aatatttttt caataaagct tgcaatttaa aagcgatgag 4800 aatatagtgt gaatcatact ttttgcatga acatgcagct aatacactat ttttgaatat 4860 ttgaggtgat tatatgcaag tcgcgctagt tggcgttacg gggtacagtg gcatggtgtt 4920 gtaccggctc ttgaaacaac atcccgagat cgatcgcatc caattatacg ggcacgtggg 4980 agcaactacg gtggcattaa agacggtggc agccatgtac cagaaagaaa cggcggttat 5040 tcgaccattc gatgcgacgg caatcatgcg cgataacgcg attgtgttct ttgcgacatc 5100 agcgggtatc acgcgacaat tggcattacc attcatcgct gctcattttc cagtcatcga 5160 tttatctggt gacttccgct tgcatgatcc agagcaatat cagcggtggt accaacgtga 5220 tccagcaccg gcgaccgctt tggcacaggc gagctacggc ttagctgata tgccggcgcc 5280 cttgtccacc tacattgcga atcccggctg ttatgcgact gctacgttat taggactagc 5340 gccacttgct cagcagcagt tggtcgaacc gacttcgatt gttgtggatg ctaagtccgg 5400 cttatctggt gctggcaaac gagcgacagc tgcgagtcat tacgtcgctg tgaatgataa 5460 tttgagttta tataagttga atcaacatca acatatccct gaaatgatgc aacagttaca 5520 gcagtggtgg tccgcgattt ctgcgattga atttactacc actttgattc cagcaacgcg 5580 tgggattatg acgacgattt atgccaaagc gaagtcagca ttgacaacga cgcaggtccg 5640 cgcagctttt accgcgacct atcatgagca gccgttcgtg caagtgctac caacggggat 5700 gccgacgctc aaggacgttg ttgggtctaa taactgtgcg ttaggcgttg attataatcc 5760 ggtcacgaac accatcgtgg ttgtgagcgt cattgacaat ttgatgaaag gtgctgcggg 5820 gcaggccgtt cagaatttta atcgctattt tgatttcgcg gttacggccg gattaccgac 5880 gttacctgta tttccctgat aaggtgcaat aagagaggaa gttatgcaga tgcaagtttt 5940 aacgaatacg aagtttgaaa cggttgcctt tcagtggccg gcaggttttt acagtgatgg 6000 cattcatatt ggtcttcgtc gtcataaaaa agattttggt tggctatttt caaaagtgcc 6060 tgccagtgcg gctggaactt atacgacgaa tcagtttcag gcagcaccaa ctaagttaac 6120 taaacagatg atcgaccagg gccaccaatt acagggactg ctgctgaaca gtgcaatcgc 6180 caattcttgt actggcgagc aggggtggca gaatgcgctg caagaacaag cctggttagc 6240 gaataaacta aacgtggcgc cgaacttgat tggcgttgct tcaactgggc tgattggtgc 6300 tcagttaccc atggataaaa tcaaaaacgg cttgccgcaa ttgaccccaa cgaagagtga 6360 cgcggtgacc tacgccgtgt taacgacaga ccagcatcca aaaaccgtct gtgtgcagtg 6420 tgaactcagc ggccagttag ttaccttgac cggttttgcc aaaggttctg gaatgattca 6480 tcccaagatg gcaaccatgc ttggttttgt caccactgat gcccaaatag atgggccagt 6540 tttacaggac atgctaagta ctaacgttga tcagacattc aatcaaatta ctgttgacgg 6600 tgacacgtct actaatgaca tggtggtcac gttggcaaat ggtctggcag ataatccgag 6660 tttacaagcg ggtaccaccg actatgatat ttttaatcag gcgttgcact atgtcttagg 6720 ccaacttgcc aagcaaattg ccgctgacgg tgagggtgcg accaagttag tcgaatgtaa 6780 tgtggtccac gccgctacaa cgtttgatgg tcagcaaatc gccaaagcaa ttgttggctc 6840 taacctcgtt aaggcggcca ttttcggtga agacccgaat tgggggcgaa tcattagcac 6900 gattggcgcc actgatgcag acatcgatgt ggcgacggtc gatattgaaa tgaacggcgt 6960 tttacttgtt caacaaagtc tggccgttga ctttgatatg gcagcggtgc aggcgacctt 7020 acgtgataac cagattatga tcgatgttga tttacatcac ggtacagcaa gtggtcaggc 7080 ttggggttgt gacttgactt acaactacgt caaaattaac gcgagctatc atacttaaac 7140 ggaggtggtg aaaatgacaa aattgattgt aattaagatt gggggccagg cgattagcca 7200 attgagcacc actttctttg accaaatcgc acagtggtac caacagcagt atcagattct 7260 gatcgtacac ggtggggggc caatgatcaa tcgactgacg actcagcttg ctttgcccgt 7320 gcataaggtg aacgggttgc gggtgacgga tgcggcgacc ttagtgctca ccaagttggc 7380 cctgctagga gatgcgcaac cagccttact tgcaaaatta acgcaacatc acctacctgt 7440 gttggggctc aatgcggcgg ataatcagtt actaactggt gaattgattg attatcgaca 7500 gctagggtat gtcggccggc tcaccgctgt caatcaagtg caattaatgc aattgttggc 7560 tcatcatatc ggtattttgg cccctttagc cttaactgag acgggacaat ggctcaatgt 7620 caatgcggat atggcagcga ccgtgctagc tcaacaacta catgctgaaa aattggtttt 7680 gctaaccgat gtcccgggaa ttatacatca cggtaatgtg atgacatcac tatcgccaca 7740 acaagctcag caattgattc gaacagctgt gatcaccgcg ggaatgcaac ccaaagttca 7800 agctgcaatt gccgcgattc agacgggagt caagcaggct attattacga atgcaatcga 7860 tcaaccagga accgcaatta ttcaggaggt ggccgtatga ccatgcaaca cgtgtttcca 7920 acctatcaac gttttccatt tgccattacg gatggtcagg gcgttcatct gactgataat 7980 catggcaaga cgtatttaga ttttacggcg ggaatcgggg tctgcaactt tgggtatcac 8040 cagccacaaa ttcaggcagc cgtcacccag cagttgacgc atatctggca tacgtcgaat 8100 ttatacgaaa atgaattaca agatgccgtt gccggcctgt tagcgaatgg tgaagagcga 8160 ctcgtatact ttgcaaattc cggaaccgaa gctaatgaag ctgcattaaa actcgcacgg 8220 aagtacacgg gtaaaaccgg catcttagct tttcagcatt catttcacgg tcgaacctat 8280 ggcgctatgt cgatgacggg caatcctcat attcaggctg gctatgcgcc attagtgcct 8340 ggcatcacgt ttgcaaccta taatgacgac gcggctttgg acaaaatcac accagagttg 8400 gcggccgtta ttttagaagt cgttcaaggt gaaggcggcg tctttgcggg acaaacagct 8460 tggttacaag cggttaatgc gaaatgccaa gcaacgggtg ttttgttgat tattgatgag 8520 gtgcagacgg gaatcggtcg gactggttac cggatggcct atgaaggtta cggcctggat 8580 cctgatatct acacggtcgc caagggctta gcgaatggct tgccagtggg ggcaatggtt 8640 ggtcggcggc aattagccac tgcctttggt ccgggcagcc atggctcgac gttcgccggt 8700 aatgctgttg ctatggcggc ggcaaaacgt gtcttgaccc aattaacacc ggcgctgtta 8760 acgacggttc gagcccatgc caaacttgtc tggcaatccc tagcgactca agtcgaaccg 8820 ataccggtag tgaaacaaat cacggggaag ggcctaatga ttggaatcca cttagatgaa 8880 caaatcccgg ttaatcaagt catcacccgg ctacaagtag aaggcttatt gacgttatca 8940 gctggcgata atacgttacg tttgttaccc ccaattgtga tgcaaccggc cgatttatta 9000 gctgggattg ccttgattgc aaaggtactg acaactttga caacggaggt cacgacgaat 9060 gaataatcaa tttgaaggtc ggtcattctt gaaggaaatc gactatacac caacagaatt 9120 agcttactta attgactttg ctagtcactt gaagaccctt aaagcacacc atatcccaca 9180 cccttattta caaggaaaaa atattgcgtt gctgtttgaa aaaacgtcga cacggacacg 9240 ttctgcgttt actgtggcgg ctaatgatct gggcgcgaat ccagagtttt tgggtaaaga 9300 cgacatccaa ttcgggacga aggagtcagt tgttgatacg gcgaaagtac tggggtccat 9360 gtatgatggc attgaatttc ggggctttaa acaaagcacg gtcgaagact tagcgaccta 9420 tagtggtgtg ccagtctgga acgggttgac cgatgagtgg cacccgacgc agattttagc 9480 ggatttttta acattaaagg aacattttgg tcatttaaaa gggttgacgt tagcgtacgt 9540 tggtgatggt cgcaataata tggctaacag tttacttgtg gcgggagcga tgctcggcat 9600 caatatcgct atcggggccc cggtagcgtt acagccagct ccagcagtgg tcgcgttggc 9660 ccaacagtat gcgcaggcag ctgggagcac ggtcgtgatt acggctgatc cgcaacaagc 9720 cgttactcag gctgatgcgc tttatacgga tgtctgggtc tcaatgggcg agcaggtcga 9780 ctatggtgag cgaatcaagc aactattgcc gtttcaaatt aatactacgt tgctcgcagc 9840 tactggcaag tcatcgacga ttgtcatgca ttgcttacca gcactacacg atctaaagac 9900 gcagctagga gccaaattag gcgaacagta cggaatgacg gcgtttgaaa ttacggatga 9960 tgtctttcag agtaagcagg cggtcgtctt tgaagaggcc ggcaaccgga tgccagcaat 10020 taaggcggta atggcggcta cattaggtaa cttatttatt cctaccagca ttttcaatta 10080 gcaagcttgc gggaactact agagcgtgct acgattatat tcgctttgtt tcaatcaata 10140 cgtggttcgt aaccatccca cgttaaaaaa actaggagga attaagcgaa tgacacaatc 10200 aaaaattcga ccatggatta tcaacgccct agtcgctgca atgtatgttg tattatgcct 10260 aggccccgca gcttttagct tggcatcggg cgcaattcaa ttccgcgttt ctgaagggtt 10320 gaaccactta gccgtgttca atcgcaagta tatttgggga attgttgctg gcgttatttt 10380 gtttgacgct tttggtcccg gtgcgagtct cctcaacgtt ctctttggtg gcggccaatc 10440 attattagcc ctgctggtat tgacgtggtt ggcccctaag ttgaagacgg tttggcaacg 10500 gatgttactg aatatcgcgc tattcaccgt ttcgatgttt atgatcgcac tgatgattac 10560 catgatgagt agtggtgtcg ctttttggcc gacatatcta acaactgctt tatcagagtt 10620 gattatcatg agtatcactg cgccaattat gtacagcttg gatcgggtct tgcactttag 10680 tgaccggatt cagtagggtg tgactgaatt taatattaag aacgaccggc gtagtatgtg 10740 aagatggttt ttcgcatatt acgccggtct cttatttatt catttaatga aatgtggtta 10800 atttgatttt tggttgatta ttttgaaatg gtcaacgcgt tttggattgt taactgctcg 10860 gcagcaatga tcgtcctaat tcgaactgtt ttcagcagtc ttaagctggt cgcttttgaa 10920 ctgaaaattc atctcataaa aaaagcccca aggtaacctc ggggcaactg tgattattca 10980 gcttgtaaat cttccacttc gatgacttta aattgtttgc gattcaagtt gtcgataatt 11040 cgtttgagct tttcactgtc gacattttct ggcaaggtaa agagcgtccg ataaccgagt 11100 gtcccgtttt ggacgtctaa ggtcaggcag ccggcgattg aagtatattt cgtgataatc 11160 ttagccatgg ctgcaagatc 11180 // |
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