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EBI DbfetchID X85787; SV 1; linear; genomic DNA; STD; PRO; 14943 BP. XX AC X85787; XX DT 29-MAR-1995 (Rel. 43, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 69) XX DE S.pneumoniae cps14 locus XX KW cps14A gene; cps14B gene; cps14C gene; cps14D gene; cps14E gene; KW cps14F gene; cps14G gene; cps14H gene; cps14I gene; cps14J gene; KW cps14K gene; cps14L gene; dexB gene; glucosyl-1-phosphate transferase; KW glucosyltransferase; ss-1,3-N-acetylglucosaminyltransferase; KW ss-1,4-galactosyltransferase; tasA gene. XX OS Streptococcus pneumoniae OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus. XX RN [1] RX PUBMED; 8682774. RA Kolkman M.A.B., Morrison D.A., van der Zeijst B.A.M., Nuijten P.J.M.; RT "The capsule polysaccharide synthesis locus of streptococcus pneumoniae RT serotype 14: Identification of the glycosyl transferase gene cps14E"; RL J. Bacteriol. 178(13):3736-3741(1996). XX RN [2] RC revised by [3] MAT RA Kolkman M.A.B.; RT ; RL Submitted (23-MAR-1995) to the EMBL/GenBank/DDBJ databases. RL M.A.B. Kolkman, Institute of Infectious Diseases and, Immunology,Department RL of Bacteriology, School of Veterinary Medicine, University of Utrecht, P.O. RL Box 80.165, NL -3508 TD Utrecht, NETHERLANDS XX RN [3] RC revised by [4] RP 1-1821 RA Kolkman M.A.B.; RT ; RL Submitted (06-SEP-1995) to the EMBL/GenBank/DDBJ databases. RL M.A.B. Kolkman, Institute of Infectious Diseases and, Immunology,Department RL of Bacteriology, School of Veterinary Medicine, University of Utrecht, P.O. RL Box 80.165, NL -3508 TD Utrecht, NETHERLANDS XX RN [4] RC revised by [5] RA Kolkman M.A.B.; RT ; RL Submitted (23-APR-1996) to the EMBL/GenBank/DDBJ databases. RL M.A.B. Kolkman, Institute of Infectious Diseases and, Immunology,Department RL of Bacteriology, School of Veterinary Medicine, University of Utrecht, P.O. RL Box 80.165, NL -3508 TD Utrecht, NETHERLANDS XX RN [5] RP 1-14943 RA Kolkman M.A.B.; RT ; RL Submitted (16-JUN-1997) to the EMBL/GenBank/DDBJ databases. RL M.A.B. Kolkman, Institute of Infectious Diseases and, Immunology,Department RL of Bacteriology, School of Veterinary Medicine, University of Utrecht, P.O. RL Box 80.165, NL -3508 TD Utrecht, NETHERLANDS XX RN [6] RX DOI; 10.1074/jbc.272.31.19502 RX PUBMED; 9235953. RA Kolkman M.A.B., Bernard A.M., van der Zeijst B.A.M., Nuijten P.J.M.; RT "Functional analysis of glycosyltransferases encoded by the capsular RT polysaccharide biosynthesis locus of Streptococcus pneumoniae serotype 14"; RL J. Biol. Chem. 272(31):19502-19508(1997). XX RN [7] RX DOI; 10.1046/j.1365-2958.1997.5791940.x RX PUBMED; 9383201. RA Kolkman M.A.B., Wakarchuk W., Nuijten P.J.M., van der Zeijst B.A.M.; RT "Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: RT molecular analysis of the complete cps locus and identification of genes RT encoding glycosyltransferases required for the biosynthesis of the RT tetrasaccharide subunit"; RL Mol. Microbiol. 26(1):197-208(1997). XX FH Key Location/Qualifiers FH FT source 1..14943 FT /organism="Streptococcus pneumoniae" FT /isolate="NCTC 11902" FT /mol_type="genomic DNA" FT /sub_clone="cMK02" FT /sub_clone="pMK100" FT /sub_clone="pMK102" FT /sub_clone="pMK118" FT /sub_clone="pMK114" FT /sub_clone="pGV100" FT /sub_clone="pMK110" FT /note="serotype 14" FT /db_xref="taxon:1313" FT CDS <1..353 FT /codon_start=3 FT /transl_table=11 FT /gene="dexB" FT /product="alpha, 1-6-glucosidase" FT /function="degradation of glucans" FT /db_xref="GOA:Q54796" FT /db_xref="HSSP:1UOK" FT /db_xref="InterPro:IPR006047" FT /db_xref="UniProtKB/Swiss-Prot:Q54796" FT /protein_id="CAA59784.1" FT /translation="PWLAVNPNYEMINVQEALANPDSIFYTYQKLVQIRKENSWLVRAD FT FELLDTADKVFAYIRKDGDRRFLVVANLSNEEQDLTVEGKVKSVLIENTAAKEVLEKQV FT LAPWDAFCVELL" FT terminator 700..753 FT repeat_region 1196..1305 FT -35_signal 1360..1365 FT -10_signal 1383..1388 FT RBS 1408..1410 FT /gene="cps14A" FT CDS 1419..2864 FT /transl_table=11 FT /gene="cps14A" FT /product="capsular polysaccharide synthesis protein" FT /function="putative regulatory" FT /db_xref="GOA:O07338" FT /db_xref="InterPro:IPR004474" FT /db_xref="UniProtKB/TrEMBL:O07338" FT /protein_id="CAA59785.1" FT /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILAFR FT YLNLVVTALVLLVALVGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNRLN FT ATSNYSEYSISVAVLADSDIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLTVDQ FT SSSYLAAYKSLIAGETKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAPKTSK FT NQSFNIYVSGIDTYGPISSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADGGNNQK FT DKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALH FT GKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNYS FT TIIDSLQDSIQTNMPLETMINLVNTQLESGGNYKVNSQDLKGTGRTDLPSYAMPDSNLY FT VMEIDDSSLAVVKAAIQDVMEGR" FT RBS 2852..2857 FT /gene="cps14B" FT CDS 2866..3597 FT /transl_table=11 FT /gene="cps14B" FT /product="capsular polysaccharide synthesis protein" FT /db_xref="GOA:P72510" FT /db_xref="InterPro:IPR016667" FT /db_xref="UniProtKB/TrEMBL:P72510" FT /protein_id="CAA59774.1" FT /translation="MIDIHSHIVFDVDDGPKSREESKALLIESYRQGVRTIVSTSHRRK FT GMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTLDALEKLEKKEIPTLNDSRY FT ALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKHVRELIDMGCYTQIN FT SYHVSKPKFFGEKYKFMKKRARYFLERDLVHVVASDMHNLDSRPPYMQQAYDIIAKKYW FT SQKSERTFVDNPRKIIMDQLI" FT RBS 3596..3600 FT /gene="cps14C" FT CDS 3606..4298 FT /transl_table=11 FT /gene="cps14C" FT /product="capsular polysaccharide synthesis protein" FT /function="putative chain length regulator" FT /db_xref="GOA:P72511" FT /db_xref="InterPro:IPR005701" FT /db_xref="UniProtKB/TrEMBL:P72511" FT /protein_id="CAA59775.1" FT /translation="MKEQNTLEIDVLQLSRALWKRKLVILLVAIITSSVAFAYSTFVIK FT PEFTSTTRIYVVNRDQGEKSGLTNQDLQAGSYLVKDYREIILSQYVLEEVVSDLKLDLT FT PKGLANKIKVTVPVDTRIVSVSVNDRVPEEASRIANSLREVAAQKIISITRVSDVTTLE FT EARPAISPSSPNIKRNTLIGFLAGVSGTSVIVFLLEFLNTRVKRPEDIENTLQMTLLGV FT VPNLSKLK" FT RBS 4297..4302 FT /gene="cps14D" FT CDS 4308..4991 FT /transl_table=11 FT /gene="cps14D" FT /product="capsular polysaccharide synthesis protien" FT /function="putative polysaccharide export protein" FT /db_xref="GOA:P72512" FT /db_xref="InterPro:IPR005702" FT /db_xref="UniProtKB/TrEMBL:P72512" FT /protein_id="CAA59776.1" FT /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVNP FT GEGKTTTSVNIARSFARAGYKTLLIDGDTRNSVISGVFKSREKITGLTEFLSGTADLSY FT GLCDTNIENLFVVQSGPVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTPPVGIVIDAV FT IITQKCDASILVTATGEANKRDVQKAKQQLEQTGKLFLGVVLNKLDISVDKYGVYASYG FT NYGKK" FT RBS 4995..5000 FT /gene="cps14E" FT CDS 5007..6374 FT /transl_table=11 FT /gene="cps14E" FT /product="glucosyl-1-phosphate transferase" FT /function="capsular polysaccharide synthesis" FT /note="homologous to Cps19fE ofS. pneumoniae serotype 19F FT and other rfbP-like proteins" FT /db_xref="GOA:P72513" FT /db_xref="InterPro:IPR017475" FT /db_xref="UniProtKB/TrEMBL:P72513" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA59777.1" FT /translation="MDKKGLEIFLAVLQSIIVILLVYFLSFVRETELERSSMVILYLLH FT FFVFYFSSYGNKFFKRGYLVEFNSTIRYIFFFAIAISVLNFFIAERFSISRRGMVYFLT FT LEGISLYLLNFLVKKYWKHVFFNPKNSKKILLLTVTENIEKVLDKLLESDELSWKLVAV FT SVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVDLPGESYDIGEIISKFETMGIDVT FT VNLNAFNKNLGRNKQIHEIVGLNVVTFSTNFYKTSHVISKRILDICGATIGLILFAIAS FT LVLVPLIRKDGGPAIFAQTRIGKNGRHFTFYKFRSMRIDAEVIKEQLMDQNTMRGGMFK FT MDNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPEQKRRLSF FT KPGITGLWQVSGRSKITDFDDVVKLDVAYIDNWTIWKDIEILLKTVKVVFMRNGAK" FT RBS 6368..6371 FT /gene="cps14F" FT CDS 6378..6827 FT /transl_table=11 FT /gene="cps14F" FT /product="putative glycosyltransferase activity enhancer" FT /function="capsular polysaccharide synthesis" FT /db_xref="GOA:P72514" FT /db_xref="InterPro:IPR013969" FT /db_xref="UniProtKB/TrEMBL:P72514" FT /protein_id="CAA59778.1" FT /translation="MKVCLVGSSGGHLTHLYLLKPFWKDRERFWVTFDKEDARSILENE FT IFYPCYYPTNRNLKNLIKNTILAFKILRKERPDIIVSSGAAVAVPFFYLGKIFGAKTVY FT IEVFDRIDAPTMTGKLVYPVTDRFIVQWEEMKKVYPKAINLGGIF" FT RBS 6813..6817 FT /gene="cps14G" FT CDS 6827..7330 FT /transl_table=11 FT /gene="cps14G" FT /product="ss-1,4-galactosyltransferase" FT /function="capsular polysaccharide synthesis" FT /db_xref="GOA:P72515" FT /db_xref="InterPro:IPR007235" FT /db_xref="UniProtKB/TrEMBL:P72515" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA59779.1" FT /translation="MIFVTVGSHEQQFNRLIKEVDRLKGEGFIQDDVFIQTGYSNYVPK FT FCKWEKLISYEKMNQLIKESDIIITHGGPATFMAVIAKGKNPIIVPRLKKFGEHVNDHQ FT MQFVKITKEIYNLIVIDDISDLHLILHNFKDKHFETYLNNERFNVRFNVEISNLFKGNK FT INEN" FT RBS 7306..7310 FT /gene="cps14H" FT CDS 7320..8492 FT /transl_table=11 FT /gene="cps14H" FT /product="putative polysaccharide polymerase" FT /function="capsular polysaccharide synthesis" FT /db_xref="InterPro:IPR019793" FT /db_xref="UniProtKB/TrEMBL:P72516" FT /protein_id="CAA59780.1" FT /translation="MKIRIEPQYFLYKYLWFIILLPKQFMQLILFFLIALTLLPTYIKE FT KQVFKIDTPSFCMVLWTIIYSISIIFNSLIDGLAVQVLFSDLSKAFNWLIAVFFYNYYL FT KMPINIDRIKRYMYYNFTILVVFVGLFYIQRGSNVILFGRSLLDWDGFTLATSYGVRYT FT GFLEYATLNGQLILFLLPLIRLFRFRFFTQTIIFAFLLEVLVLSKSRIAIVAMLIYIAF FT AVVNEINSNNKWLIGIFCPIIPFMLFYNFEKIKQIFFQMFSSRSGSNATRFRVYEESLK FT AINGMEMLLGAGVRIPSTVDILLGSHSMYISFIYRTGVLGSIIITVMFYYLFSKFLKCD FT SSERLRSIGYILALSVFWLFEELDPHYWCLILFFSTISIFINNRKEEIVG" FT RBS 8475..8479 FT /gene="cps14I" FT CDS 8489..9409 FT /transl_table=11 FT /gene="cps14I" FT /product="ss-1,3-N-acetylglucosaminyltransferase" FT /function="capsular polysaccharide synthesis" FT /db_xref="GOA:O07339" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:O07339" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA59781.1" FT /translation="MIEVSIIIPIYNAEKTIKNCVDSALKQNLESLEVILVNDGSNDST FT SKILEQYGDNPQVMIFHQVNMGVSAARNVGLSYASGEYVFFLDSDDILDEGMLSKMYQF FT AKSNKIDLLSCWHKEPSTTQYGGNDNSSASFIARTKEEIGNHFVDIFPRSACAKLFLRR FT RIEENNIAFSTEMSLGEDMSFVCQYLMVSRSIAVIDGLYYTIQNVNPQSLSKRYVSNIE FT NSLLMQNQLWDQLLEVYPKIEENYYKQHMDFRFYLASLYVNNLFKFDSPYSSKEKWDNI FT AQQLKKYRPFLDEKVSKEKKPKKYE" FT RBS 9510..9515 FT /gene="cps14J" FT CDS 9524..10480 FT /transl_table=11 FT /gene="cps14J" FT /product="ss-1,4-galactosyltransferase" FT /function="capsular polysaccharide synthesis" FT /db_xref="GOA:O07340" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:O07340" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA59782.1" FT /translation="MEDLVSIVVPVYNVEKYLKKSIESILNQTYDNLEVLLVDDGSTDS FT SGEICDSFIKVDSRIRVFHKENGGLSDARNFGIEHMKGQYVSFIDGDDYISKDYVWKLY FT HSLKNNNSEVSICSFSLVDETGEKIKDELLDSGEVSLSGQQILEKALTADGYRYVVAWN FT KLYRSTLFEKLKFKKGMLYEDEFLNYPLFWDCKRVSIVEEPLYLYVQRKGSIIQSNMTL FT EKIKMKDKMHTSRIEFYAEKKNSFLHQRSCQQYCNWIVTITVSHYNVLNVAFLKYLQHQ FT FRRIVKYTQNDDKKLIIQNILGYINIRLAAYVKSKVM" FT RBS 1054..10552 FT /gene="cps14K" FT CDS 10568..11416 FT /transl_table=11 FT /gene="cps14K" FT /product="capsular polysaccharide synthesis protein" FT /db_xref="GOA:O07341" FT /db_xref="InterPro:IPR008441" FT /db_xref="UniProtKB/TrEMBL:O07341" FT /protein_id="CAA59783.1" FT /translation="MFPIYIISNQNIAFQQEIDIAYRKMKRQFSHISLTESEQKNDMNI FT SNKVWICWFQGEERPPELIRTCIQSMRTHFLGREIIVLTEENISDYIDIPDYITDKYKK FT GSISRAHYSDILRVELLCRYGGLWVDVTVLNTGGDFSNLELPLFVYKYLDLSRKDSQAI FT VASSWLISSYSNHPILLYARKLLWEYWRRKNSLCNYFLFHIFFTTATELYPIEWSAVLT FT FNNHSPHMLNFELNNQFSEKRWEQLKQISVFHKLNHHIDYSIGVNNFYKFIVSSKVEKN FT E" FT RBS 11395..11399 FT /gene="cps14L" FT CDS 11409..12872 FT /transl_table=11 FT /gene="cps14L" FT /product="putative repeating unit transporter" FT /db_xref="GOA:O07342" FT /db_xref="InterPro:IPR002797" FT /db_xref="UniProtKB/TrEMBL:O07342" FT /protein_id="CAA59772.1" FT /translation="MSNKISKNLAYNIGYQLIGIAFPLITSPYLSRILGAENLGIHSFT FT ISVALYFMMFMLLGIANYGNRTIATVKREGKEILSKTFWNIYYVQLLMSVLVTIAYLIY FT LYFWVSSYKFIAILQLFLLLSNAVDITWLFYGLEDFKQIVFRNALVKLLGLFLIFSFVH FT ESSDLWKYTLINGGVTLVGQLLLWGQLKGRLSWVKIQKKDLLSHIKPILVLFIPVLAIS FT IFSNMDKYMLGLMVGVKQVGFYDNANRIIDIPKALIAALEAVMLPRTSYLLAEGQEEKS FT NYYIEVTILYAMMISSVLIFGIISVSDIFSLVFWGEEFLESGRLIAAMAPVFVFSVPGN FT IIRTQYLIPRAKDKDYVLSLIIGALVNILLNCFLIKPFGAMGATISTVLAEFVLYGVQF FT WTVRRDLDFKKYLKNGFIFYLFGMIMYLAIIAAKAHLQYNIINLVLLIVLGGIVYTGFC FT CFYILISRNVHFEILREKIKRKIGYENIL" FT terminator 12903..12950 FT CDS 12856..13935 FT /transl_table=11 FT /gene="tasA" FT /db_xref="GOA:O07343" FT /db_xref="InterPro:IPR007554" FT /db_xref="UniProtKB/TrEMBL:O07343" FT /protein_id="CAA59773.1" FT /translation="MKIYYKLLLKRLIFPPFYLVVTNKYWLPLNKRKVVFDNFGGRGYG FT DNPKYIADELLKQDENLDLVWVVENMSTFVPKGVRKVWYGSWGAFFEWSTAKVWIDNIR FT NSDRPWKRKNQVYLQTWHGSDGVKIIEKDAESTLSKSYIRMAKYDGSISDAIISSCQLQ FT TQTEQFKKSFWLADNVEILEYGLPRNDDFFQKKKVDHINHTVRSKYNISLDELVILYMP FT TFRDDASTKAYNLDYDKVINSFQDFYNRKVKVLIRFHPNVDNTFFNNTDKRLINVTDYP FT NPQDLMFVADIMISDYSSAPIDFLLLNRVVFLYLPDFKEYQSDKNPFFEVFKVSKTKGI FT ALDPFDEIIGRFQFGVRIV" FT misc_feature 13818..13949 FT /note="similar to insertion element IS1167" XX SQ Sequence 14943 BP; 5043 A; 2059 C; 2848 G; 4993 T; 0 other; aaccttggtt ggcggttaat ccaaattacg agatgatcaa tgtccaagaa gcgctggcaa 60 atccagattc tattttctat acctatcaga aactggtcca aattcgcaag gagaatagct 120 ggctagttcg agctgacttt gaattgcttg atacggctga taaggtcttt gcttatatac 180 gtaaggatgg cgaccgtcgc ttcctagttg tggctaactt gtccaatgaa gagcaagact 240 tgacagtaga aggaaaagtc aaatctgtct tgattgaaaa cactgcggct aaagaagtac 300 ttgaaaaaca ggtcttggct ccatgggatg ctttctgtgt ggaattacta taaatatttt 360 ttgcagaaaa atttaaaatt gaaatcatgt aaaaacaagg gaggactgta taaaagacag 420 aaatcctttg ttttttataa ccaaggttta taaactttca ttctcgaaat tcaattaact 480 ttacaaattc ccactattaa ggagaaagaa gatgaacata aagaagcgtg tccttagtgc 540 aggtctgact tttgcatctg ctttgcttta gctgcttgcg gccaatcagg ttcagataca 600 aaaacttact catcaacctt tagtggaaat ccaactacat ttaactatct attagactat 660 tacgctgata atacagtcaa ttgaaataag agcaggataa aaaagcctcg taaaaggtat 720 tgcaacttgg taataccttt tacgaggctt tttgatatga gcccatgttt tctcaatagg 780 attgtactca ggtgagtagg gaggaagagg taaaagttta tgcccaaact cttcgcataa 840 aagttctagc ttccccattc tatggaatct tgcattatcc ataataataa ccgatggtgt 900 ggttaatgtt ggtaagaaaa acttctgaaa ccatacttca aaaaagtcgc tcgtcatcgt 960 ttcttcgtaa gtcattggag cgattaactc accatttgtt agacctgcaa ccaaagaaat 1020 cctctgatat cttcttccag atactttgcc tcttcttaac tgacctttta atgagcgacc 1080 atattctcga taaaaataag tatcgaatcc tgtttcatca atctaaacag gtgataggtg 1140 ctttaaacta ttaaaattct taagaaataa ggctactttt tctgggtctt gttcataatt 1200 agattgaaac tagaatagta cacttctgct tctaaaacat tgttagaaat cgatttgact 1260 gtcctgatcg atttgtcatg ttcttatttc attttactat atttttgttt cgcgggaagt 1320 ctactaagat acttaaagat gcagatagta aaaaaaatgt agacattacc gtaaaaaagt 1380 gatataattg tacgatgttc aaggtatagg tgttaatcat gagtagacgt tttaaaaaat 1440 cacgttcaca gaaagtgaag cgaagtgtta atatcgtttt gctgactatt tatttattgt 1500 tagtttgttt tttattgttc ttaatcttta agtacaatat ccttgctttt agatatctta 1560 acctagtggt aactgcgtta gtcctactag ttgccttggt agggctactc ttgattatct 1620 ataaaaaagc tgaaaagttt actatttttc tgttggtgtt ctctatcctt gtcagctctg 1680 tgtcgctctt tgcagtacag cagtttgttg gactgaccaa tcgtttaaat gcgacttcta 1740 attactcaga atattcaatc agtgtcgctg ttttagcaga tagtgatatc gaaaatgtta 1800 cgcaactgac gagtgtgaca gcaccgactg ggactgataa tgaaaatatt caaaaactac 1860 tagctgatat taagtcaagt cagaataccg atttgacggt cgaccagagt tcgtcttact 1920 tggcagctta caagagtttg attgcagggg agactaaggc cattgtctta aatagtgtct 1980 ttgaaaatat catcgagtca gagtatccag actacgcatc gaagataaaa aagatttata 2040 ccaagggatt cactaaaaaa gtagaagctc ctaagacgtc taagaatcag tctttcaata 2100 tctatgttag tggaattgac acctatggtc ctattagttc ggtgtcgcga tcagatgtca 2160 atatcctgat gactgtcaat cgagatacca agaaaatcct cttgaccaca acgccacgtg 2220 atgcctatgt accaatagca gatggtggaa ataatcaaaa agataaatta acccatgcgg 2280 gcatttatgg agttgattcg tccattcaca ccttagaaaa tctctatgga gtggatatca 2340 attactatgt gcgattgaac ttcacttctt tcttgaaaat gattgactta ttgggagggg 2400 tagatgttca taatgatcaa gagttttcag ctctacatgg gaagttccat ttcccagtag 2460 ggaatgtcca tctagactct gagcaggctc taggttttgt acgtgaacgc tactcactag 2520 ccgatggaga ccgtgaccgt ggtcgcaacc aacaaaaggt gattgtggct atccttcaaa 2580 aattaacgtc aaccgaagca ctgaaaaatt atagtactat cattgatagc ttgcaagatt 2640 ctatccaaac aaatatgcca cttgagacta tgataaattt ggtcaatact cagttagaaa 2700 gtggagggaa ttataaagta aattctcaag atttaaaagg tacaggtcgg acggatcttc 2760 cttcttatgc aatgccagac agtaacctct atgtgatgga aatagatgat agtagtttag 2820 ctgtagttaa agcagctata caggatgtga tggagggtag atgaaatgat agacatccat 2880 tcgcatatcg tttttgatgt agatgacggt cccaagtcaa gagaggaaag caaggctctc 2940 ttgatagaat cctacaggca gggggtgcga accattgtct ctacctctca ccgtcgcaag 3000 ggcatgtttg aaactccgga agagaagata gcagaaaact ttcttcaggt tcgggaaatt 3060 gcaaaagaag tagcagatga tttagtcatt gcttatggcg cagagatata ctatactctg 3120 gatgctctag aaaagctaga aaaaaaagaa attcctaccc ttaatgatag tcgttatgcc 3180 ttgattgagt ttagcatgca tacttcctat cgtcagattc atacgggatt gagcaatatt 3240 ttgatgttgg gaatcacgcc agtaattgct catattgaac gttatgatgc tttagagaat 3300 aacgaaaaac atgttcgtga actgattgat atggggtgct atactcagat aaatagttat 3360 catgtttcaa aacctaagtt ctttggtgaa aaatataaat tcatgaaaaa gagagctcgg 3420 tattttttgg aacgtgattt agttcatgta gttgcaagtg acatgcacaa tttagacagt 3480 agacctccat atatgcaaca ggcatatgat atcattgcta agaaatattg gagccaaaaa 3540 agcgaaagaa cttttgtaga taatcccaga aaaattataa tggatcaatt aatttaggag 3600 aaaatatgaa ggaacaaaac actttggaaa tcgatgtatt gcaactatcc agagctttat 3660 ggaaaagaaa gttagtcatt ttattagtgg caattataac ttcttcagtt gcttttgcct 3720 acagtacttt tgttatcaaa cctgagttta ctagtacgac tcggatttat gtagttaacc 3780 gtgatcaggg agagaagtct ggtttaacca atcaagactt gcaggcagga tcatacttgg 3840 ttaaagacta tcgtgaaatt atcctatcgc agtatgtttt ggaggaagtt gtttctgatt 3900 tgaaactaga tttgacgcca aaaggtttgg ctaataaaat taaagtaaca gtaccagttg 3960 atacccgtat tgtctctgtt tcagttaatg atcgagttcc tgaagaggca agccgtatcg 4020 ctaactcttt gagagaagta gctgctcaaa aaattatcag tattactcgt gtttctgatg 4080 tgacaacact ggaggaggca agaccggcga tatcaccgtc ttcgccaaat attaaacgca 4140 atacactaat tggttttttg gcaggggtga gtggaactag tgttatagtt tttcttcttg 4200 aatttttgaa cactcgtgtg aaacgtccgg aagatatcga aaatacactg cagatgacac 4260 ttttgggagt tgtaccaaac ttgagtaagt tgaaatagga gagaggaatg ccgacattag 4320 aaatagcaca aaaaaaactg gagttcatta agaaggcaga agaatattac aatgccttgt 4380 gtacaaatat acagttgagc ggagataaac taaaagtaat ttccgttact tctgttaacc 4440 ctggggaagg aaaaacaact acttccgtaa atatagcaag gtcgtttgcg cgtgcaggct 4500 ataaaactct tttgatcgat ggcgatactc gaaattcagt tatatcagga gtttttaaat 4560 cgcgtgaaaa aattacaggg ctaacagaat ttttatctgg gacagctgat ttatcttacg 4620 gtttatgtga tacaaatatt gaaaatttat ttgtagttca atcgggacct gtatcaccaa 4680 accctacagc cttgttacaa agtaaaaatt ttaatgatat gattgaaaca ttgcgtaaat 4740 attttgatta tatcattgtt gatacaccac ctgttggaat tgttattgat gcggtaatta 4800 tcactcaaaa gtgtgatgcg tccatcttgg taacagcaac aggtgaggcg aataaacgtg 4860 atgtccaaaa agcgaaacaa caattagaac aaacagggaa actgttccta ggagttgttt 4920 taaataaatt ggatatctcg gttgataagt atggagttta cgcttcctat ggaaattatg 4980 gtaaaaaata acttaggaaa gattttatgg ataaaaaagg attggaaatt tttctggcag 5040 tattacagag tattattgtc attttattgg tttattttct tagctttgtt agagagacag 5100 aacttgaacg ttcttcgatg gttatactat accttctcca cttttttgta ttctatttta 5160 gttcctatgg taacaaattt tttaaaagag ggtacctagt tgagtttaat agtactataa 5220 gatatatttt tttctttgca atagctataa gtgtattaaa cttttttata gcggaacggt 5280 ttagtatctc tagaagagga atggtatact tcttaacttt agaaggaata tccttatact 5340 tgttaaattt cttagtaaag aaatattgga agcatgtgtt ttttaatcca aaaaatagca 5400 agaaaatttt actgttaaca gtaacggaaa atatagaaaa agttcttgat aaattgctag 5460 aatctgatga actttcatgg aaactggtag cagtaagtgt tttggataaa tctgattttc 5520 aacatgataa aatacctgta attgaaaagg aaaaaattat tgaatttgca acgcatgaag 5580 ttgtggatga ggtgtttgtc gatcttccag gagagagcta tgatattgga gaaattatct 5640 ctaagtttga gacaatgggg atagatgtaa ctgtaaatct taatgcattt aataagaatt 5700 tgggtcgtaa taaacaaatt catgagatag taggattgaa tgtagtcact ttctctacaa 5760 atttttataa aactagtcat gtgatttcaa agagaattct cgatatttgt ggtgccacta 5820 ttggccttat tctttttgct atagctagtc tagttttagt tccattgatt cgtaaagatg 5880 gcggaccagc tatttttgct caaactcgta tagggaaaaa tggtcgacat tttacctttt 5940 ataaattccg ttcgatgcgg atcgatgctg aagttatcaa agaacagttg atggatcaaa 6000 atacgatgcg aggtggtatg tttaagatgg acaatgatcc tcgtgttaca aaaattggtc 6060 gctttattcg taaaaccagt ttagatgagt taccccagtt ttggaatgtc tttataggag 6120 atatgagttt ggtgggaaca cgtccaccta cagtagacga gtatgatcag tatactccag 6180 aacagaaacg tcgactcagc tttaaacctg gtattacagg tttatggcag gttagcggcc 6240 gtagtaaaat aaccgatttt gacgatgttg taaaattaga tgtggcttat attgataatt 6300 ggacaatctg gaaagatatt gaaattttgc ttaaaactgt taaagttgta tttatgagga 6360 atggagcgaa gtaagggatg aaagtatgtc tagttggatc tagtggaggt catttaactc 6420 atttgtattt attaaaacct ttctggaaag atagagaaag attttgggtg acttttgata 6480 aagaagatgc aagaagtatt ttagaaaatg aaatatttta tccatgttat tatcctacta 6540 atcgtaatct aaaaaatctt attaaaaata cgattcttgc tttcaaaatt ttgagaaagg 6600 aacgccctga tattatcgtc tcatcagggg cagctgtagc agttcctttc ttttatctag 6660 ggaaaatatt tggtgctaag acagtctata tagaagtatt tgatagaatt gatgctccga 6720 caatgactgg gaaacttgtt tatccagtaa ctgacaggtt tattgtacaa tgggaagaaa 6780 tgaaaaaagt atatccgaaa gcaatcaatc tcggagggat tttctaatga tttttgtgac 6840 agtaggttct catgaacaac agtttaatcg acttataaaa gaggttgata gattaaaagg 6900 tgagggattt attcaggatg atgtttttat tcaaacagga tactctaatt atgttccaaa 6960 attttgtaaa tgggaaaaat taatatctta tgaaaaaatg aatcaattga ttaaggaatc 7020 agatattatc attacccatg gcggtccagc tacgtttatg gcagttattg ctaaaggtaa 7080 aaatccaata attgttccgc ggctaaaaaa atttggtgag catgtaaatg atcaccagat 7140 gcaatttgta aaaataacga aagaaatata caatttaata gttatagatg atatttcaga 7200 cttacattta attcttcata attttaagga caaacatttt gaaacttatt tgaataacga 7260 gagatttaat gtacgtttca atgtggaaat cagtaacctt tttaaaggaa ataaaataaa 7320 tgaaaattag aatagaacct cagtattttc tttataaata cctttggttt attatcctac 7380 ttccaaaaca gtttatgcaa ttaatattat tctttttaat tgctttaact cttttaccaa 7440 cctatataaa agaaaaacaa gtttttaaaa tagatacacc gtctttttgt atggtgctat 7500 ggactattat atattctata tctataatat ttaattctct gattgatgga ttggctgttc 7560 aagtgttatt ttcagatttg agtaaagcat ttaattggct aatagcagta tttttttata 7620 attattattt gaaaatgcca atcaatattg acaggataaa gagatatatg tattataatt 7680 ttactatctt agttgttttt gtcggtttat tctatataca aagaggctcc aatgtaattt 7740 tgtttggaag aagtttgtta gactgggacg gatttacatt agctactagt tatggtgtaa 7800 gatatacagg ttttttagaa tacgcaactt taaatggtca gttaattctt tttttattac 7860 cgttaattag attgtttaga tttagatttt ttacacaaac tatcattttt gcttttcttc 7920 tagaggtttt ggtactaagc aaatctagaa tagcgattgt tgcaatgctt atatatatag 7980 catttgcagt agtcaatgag attaattcaa acaataaatg gcttattgga attttctgtc 8040 caattattcc ttttatgtta ttttacaatt ttgaaaaaat taaacagatt ttttttcaaa 8100 tgtttagttc tagatcgggt agcaatgcga cacgctttag agtgtatgag gaatccctaa 8160 aagctattaa tggaatggaa atgttacttg gcgcaggtgt cagaattccc tctacagtag 8220 atatattatt ggggtcacat tctatgtata taagttttat ttataggaca ggagttttag 8280 gaagtataat aataacagta atgttttatt atctgttttc taaattttta aaatgtgatt 8340 catctgagag actaagaagt attggctata ttctagcttt gtcagtattt tggctttttg 8400 aagagttaga tccacattat tggtgtttaa ttttattttt ttcaacaata agtattttca 8460 taaacaatag aaaagaggaa atagttggat gatagaagta tcaatcataa ttccaatata 8520 caatgctgaa aaaactatta aaaattgtgt tgatagtgcc ttaaagcaaa atttagaatc 8580 tcttgaagtg attttggtga atgatgggtc taacgattct acatcaaaaa ttcttgaaca 8640 gtatggtgat aatccccaag tgatgatttt ccatcaagtg aacatgggag tatctgctgc 8700 cagaaacgta ggattatcgt atgcaagcgg agagtatgtg ttctttttag attcagatga 8760 tatattagat gaaggtatgc tatctaaaat gtatcagttt gcaaaaagta ataaaattga 8820 tcttttatct tgttggcata aagagcctag tacaacacaa tacggtggta atgataatag 8880 ttcagcttca tttattgcac gaacaaaaga ggaaatagga aatcattttg tggatatttt 8940 tccgagaagt gcttgtgcta agttatttct tcgtagaaga attgaggaaa acaatattgc 9000 tttttcgact gaaatgtcac taggagaaga tatgtcattc gtttgccaat acttgatggt 9060 ctcaaggagt attgcagtaa ttgatggact gtattatact attcagaatg ttaatccaca 9120 gtcattatct aagcgatatg taagtaatat cgaaaactcc ctattaatgc agaatcagtt 9180 atgggatcaa ttattagaag tttatcctaa aattgaggag aactactaca agcaacatat 9240 ggattttaga ttttatcttg ctagtttata tgtgaataat ttatttaaat ttgattctcc 9300 gtattcctca aaagaaaaat gggataatat tgcacaacaa ttaaaaaaat atagaccatt 9360 tttagatgag aaagtgagca aagaaaagaa gcctaaaaaa tatgaatgag atggtcattt 9420 tttatttact gaagtctaaa attcccgcgt taatctattc tttttactca tttaaagaat 9480 ggtggaagaa aaagcgatta aaaaattgaa ggagaaatca gttatggaag atttagtaag 9540 cattgtcgtt ccggtctata atgtagaaaa atatttaaaa aaatcaatag aaagtatttt 9600 gaatcaaacg tatgataacc ttgaggttct attagtcgat gatggcagta cagatagtag 9660 tggggaaatt tgcgattcat ttattaaagt tgattcaaga ataagagtgt ttcataaaga 9720 aaacggtggt ttatcggatg ctcgaaattt tggaatagag catatgaaag gccaatatgt 9780 atcgtttatt gatggcgatg attatatatc taaggattat gtgtggaagt tgtatcattc 9840 tctaaaaaac aataattcag aggtgtctat atgttctttt tcattggttg atgaaacggg 9900 tgaaaagata aaagatgagc tactagattc tggggaagta tccttgtctg gtcaacaaat 9960 attagaaaaa gcgttaacag cagatggtta tcgctatgtt gttgcttgga ataagcttta 10020 tcggtcaact ttatttgaaa aattaaaatt taaaaaagga atgttgtatg aggatgaatt 10080 tcttaactat cctctatttt gggactgtaa aagggtatca attgtagagg agccgttata 10140 tttatacgtt caacgaaaag gaagcattat acaaagtaat atgactttag aaaaaataaa 10200 gatgaaggat aaaatgcata catcgcgtat tgaattttat gcagaaaaaa agaattcctt 10260 tttacaccaa cgttcgtgtc aacagtattg taactggatt gttacaataa ctgttagtca 10320 ttacaatgtt ttgaatgtag cctttttaaa atatttgcaa catcaattta gaagaattgt 10380 taaatataca caaaacgatg ataagaaact gattatacag aatattttag gctatataaa 10440 tattcgttta gcagcttatg taaaatcaaa agtaatgtag ggtgtaagga gaaataatgc 10500 tggaaaaaat tttagcttct attaacaatc gctctttttt agtaaattga aaaataaaat 10560 tcatagaatg tttccgatat atattatcag caatcaaaat atagcttttc aacaagagat 10620 tgatattgct tatagaaaaa tgaagcgaca atttagccat atttcgttga ctgaaagtga 10680 acaaaaaaat gatatgaaca tttcgaataa agtttggatt tgttggtttc agggcgaaga 10740 acgccctccg gagttaatta gaacatgtat tcaatcaatg agaactcatt ttcttggaag 10800 agagattatc gtactgacag aagaaaatat aagtgactat atagatatac cagattatat 10860 cactgataaa tataaaaagg gttcgatttc tcgtgcacat tattcagata tccttcgggt 10920 agaactctta tgtcgttatg gaggattatg ggtagatgta acagtgttga atacaggagg 10980 agatttctca aatcttgagt tgccactttt tgtatataaa tatttggatt tatcaagaaa 11040 agattctcaa gccattgtag catcaagttg gttaatttcg tcatatagta atcatcctat 11100 attgctgtat gcgagaaaac tactctggga gtattggcgt agaaaaaata gtttatgcaa 11160 ttatttttta tttcatatat tctttacaac agctacagag ctgtacccaa tcgaatggtc 11220 tgctgtcctt acttttaaca atcattctcc tcatatgctt aattttgagt taaataatca 11280 attttcagaa aaaaggtggg aacagctaaa acagatatcg gtgtttcata aattaaatca 11340 tcatatagat tattctatcg gtgttaacaa tttttataag tttatagtat cttcgaaagt 11400 tgagaaaaat gagtaataaa atcagtaaaa atttagccta caatatagga tatcaattaa 11460 ttggtattgc ctttcctttg ataacttctc cttatttatc acggatatta ggcgctgaaa 11520 atttaggtat tcattctttt actatctcag tagcacttta ctttatgatg tttatgctac 11580 ttggaattgc aaattatgga aataggacaa tagcgaccgt taaacgagaa gggaaagaga 11640 ttttatcaaa aacgttttgg aatatctact atgtccagtt gctaatgtcg gttctagtaa 11700 ctatcgcata tctcatttat ttatattttt gggtgtcgag ttacaagttc attgcgattt 11760 tacaactttt tttgttatta tcgaatgcag ttgatattac ttggttattt tatggattag 11820 aagattttaa acaaattgtt tttagaaatg cattagttaa acttcttggt ttgtttttaa 11880 tattttcgtt tgtacatgaa agctcagatt tatggaagta caccttaata aacggaggag 11940 tgactttagt tgggcaactt ttgttatggg gacaattaaa aggcagatta tcttgggtga 12000 agattcaaaa aaaggattta ctatctcata tcaaaccaat tttagttctt ttcattcctg 12060 tgttagcaat cagtatcttt agtaatatgg ataaatatat gcttggttta atggttggtg 12120 ttaagcaagt tggattttat gataatgcaa atcgtattat cgatattcct aaagcattaa 12180 ttgcagcatt agaggctgtt atgttaccac gaacatctta tttattagca gaaggtcagg 12240 aggaaaaaag taattactat atagaggtta caatccttta tgcgatgatg atttcgagtg 12300 tattgatatt tggtataata tcggtttctg atattttctc gcttgtattt tggggagaag 12360 aattccttga atcaggaaga ttaattgctg ctatggcacc agtttttgtt ttttctgttc 12420 caggaaatat aattagaaca cagtatttga ttcctagagc aaaggataaa gattatgtgt 12480 tgtctctaat aataggtgct ctagttaata tattattgaa ctgtttctta ataaaacctt 12540 ttggagccat gggtgctacg attagtacag ttttggcaga atttgtcttg tatggagtgc 12600 aattttggac agtcagaaga gatttagact ttaaaaaata tttaaagaat ggttttatat 12660 tttacctatt tggtatgatt atgtatttag ctattatagc agcaaaagct catttgcaat 12720 ataatataat aaatcttgtt ctccttatag tgctgggagg aatagtatat actggctttt 12780 gttgtttcta cattttaata tcaagaaacg tacattttga gatattacgg gaaaaaatta 12840 aacgaaagat tggttatgaa aatatattat aaattattat taaagagatt aatatttccc 12900 cccttttatt tagtggtaac caataaatat tggttaccac taaataaaag aaaagttgta 12960 tttgataact ttggtggtag aggatatgga gacaatccaa agtatattgc tgatgaacta 13020 ttaaaacaag atgagaatct tgatttagtt tgggtagtgg aaaatatgag tacttttgtt 13080 ccaaaaggag ttagaaaagt atggtatgga agttggggag ctttttttga atggagcacc 13140 gcaaaggtat ggattgacaa cattagaaat tcagatcgtc cttggaaaag gaaaaatcaa 13200 gtttatttgc aaacatggca tggttctgat ggagttaaaa taatcgaaaa agatgcagag 13260 tcaacacttt caaaatcata tatcaggatg gctaaatacg atggtagcat ctctgatgca 13320 atcatttcta gttgccaact gcaaacacaa acagaacagt ttaaaaaatc attttggttg 13380 gctgataatg ttgaaatctt ggagtatggt ttaccaagaa atgatgattt ttttcaaaaa 13440 aagaaagttg accatataaa ccatacagtc agatctaagt ataatatctc cctagatgaa 13500 ttggtaattt tgtatatgcc tacttttagg gatgatgctt caacgaaggc gtataatctt 13560 gattacgata aggtaataaa ttcatttcaa gatttttata acagaaaagt taaagtattg 13620 attcgttttc atccaaatgt agataataca ttttttaata atactgataa aagattaatt 13680 aatgtgacag attatcctaa tccgcaggat ttaatgtttg tggctgatat tatgatttca 13740 gactattcgt cagcacccat agattttttg ttattaaatc gagtagtctt tctgtatcta 13800 ccagatttta aagaatatca gagcgataaa aatccgtttt ttgaagtttt caaagtttcg 13860 aaaaccaaag gcattgcgct tgatccgttt gatgagatta ttggtcgctt ccagtttggc 13920 gttagaatag tgtagttgaa gggcgttgat aatctttttg gagtttacag aaagaattaa 13980 ctagaacata aggagaaaaa taattgttaa aattgataca aaacaagaaa aaggcgggaa 14040 ctaaaaagtg aaaaaatcta taatgacaaa ttttgttaaa tttagaaaaa acaatttaac 14100 tagacgcaaa ggaatattga gctttgttgt agcgtttacg ctcttactta cttacttact 14160 tacttactgc gtcgcgaccc gtatttgcag ggggatttcc gaatgatgca aaaggaatat 14220 cagggaacgg taaatattat tctttaggac aaattgaaaa attatattct aatcaattcg 14280 caacgtataa taatttgacg gtgattacat ctgatacaca cgagaactct gataattttg 14340 ccttttgttt agcgaatgga aaaaggtttc catcatttac tgatgagaaa cctaaaggaa 14400 tctacacctt ggttaaagat attaataagg agcagtatac taagttacta aaagagaacc 14460 ataaatggtc atcaattcca aatcttaatc aagcatggga tactttctca agattatctt 14520 atatgtattt gaaagatccc actgatattg ttaaaagagc ctggggaacc gatttaaata 14580 cagctcgaac ttattttcat caggttatac agtacgaaat atggagatat acggatggta 14640 tgagagtatc tagtgataca aacgtctata tatacgaaaa attttctccg caacaaaaaa 14700 aggccttgga aatgattcgt actgacttat ataattttac agtcccatat gaaaatcttg 14760 aatatagatt ttataagcca gattgggtat ttggtttagg atttcaagct ttagcaacag 14820 ttagatggaa aattgaacca gctaccatta ctgttactaa aaaatgggaa aatgtaaaag 14880 aaggagctga aaagcctgag gtctggattc aattgctcaa agatgacaaa cctgaagggg 14940 atc 14943 // |
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