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EBI Dbfetch

ID   X85250; SV 1; linear; genomic DNA; STD; PRO; 9585 BP.
XX
AC   X85250;
XX
DT   14-FEB-1996 (Rel. 46, Created)
DT   18-APR-2005 (Rel. 83, Last updated, Version 6)
XX
DE   P.furiosus vorA, vorB, vorD, porA, porB, porC, porD and ORFZ genes
XX
KW   2-ketovalerate ferredoxin oxidoreductase; porA gene; porB gene; porC gene;
KW   porD gene; pyruvate ferredoxin oxidoreductase; vorA gene; vorB gene;
KW   vorD gene.
XX
OS   Pyrococcus furiosus
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
XX
RN   [2]
RP   1-6192
RA   Kletzin;
RT   ;
RL   Submitted (13-MAR-1995) to the EMBL/GenBank/DDBJ databases.
RL   A. Kletzin, Dept. for Biochemistry and Center for Metalloenzyme Studies,
RL   Life Science Building, University of Georgia, Athens, GA 30602, USA
XX
RN   [3]
RP   1-9585
RX   PUBMED; 8550425.
RA   Kletzin A., Adams M.;
RT   "Molecular and phylogenetic characterization of pyruvate and
RT   2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and
RT   pyruvate ferredoxin oxidoreductase from Thermotoga maritima";
RL   J. Bacteriol. 178(1):248-257(1996).
XX
CC   Related sequence: X85171
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..9585
FT                   /organism="Pyrococcus furiosus"
FT                   /sub_species="DSM 3638"
FT                   /mol_type="genomic DNA"
FT                   /clone="pPP23, pPP24 and pPP25"
FT                   /db_xref="taxon:2261"
FT   CDS             complement(<1..194)
FT                   /transl_table=11
FT                   /gene="frxB"
FT                   /product="putative transmembrane protein"
FT                   /db_xref="GOA:Q51794"
FT                   /db_xref="UniProtKB/TrEMBL:Q51794"
FT                   /protein_id="CAA59495.1"
FT                   /translation="MNILIPLLLGIIIGYILRERRKKIDTELLMSVSVLVLIFLMGVRT
FT                   GNVKIDATKVLLYSIAIMIS"
FT   RBS             complement(191..196)
FT                   /gene="frxB"
FT   CDS             complement(196..609)
FT                   /transl_table=11
FT                   /gene="frxA"
FT                   /db_xref="GOA:Q51795"
FT                   /db_xref="InterPro:IPR000671"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51795"
FT                   /protein_id="CAA59496.1"
FT                   /translation="MGDDGVGIKIGRELKRQGYKVEELGTDIFSLMRVYNGENKVIIVD
FT                   AVLGEIPGKVVYFKGEDIFKKLRAEIRSAHFMGAVEGLKLLLEVDERLKNAELHFVGVT
FT                   IKEPKLGLELSEEVKRAIPRAMELILSIIREGE"
FT   RBS             complement(614..621)
FT                   /gene="frxA"
FT   terminator      complement(650..669)
FT                   /note="transcriptional terminator for aca operon"
FT   promoter        complement(671..677)
FT                   /note="BoxA promoter sequence for frx operon"
FT   CDS             complement(680..1090)
FT                   /transl_table=11
FT                   /gene="acaC"
FT                   /note="unknown protein in aca operon"
FT                   /db_xref="InterPro:IPR002878"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51796"
FT                   /protein_id="CAA59497.1"
FT                   /translation="MGKPMQVSRYWRHFREKYRLIGGKCENGHLLFPKRPICPICGSRN
FT                   IEEFQFSGKGKVITWTIVRNPPSGFEYYKPYPLALVQLEEGPVVLAQLTDVEPEEIKEG
FT                   MEVEMVTRKIREFDEDGLILYGYKFRPIIKSE"
FT   RBS             complement(1086..1093)
FT                   /gene="acaC"
FT   CDS             complement(1092..2258)
FT                   /transl_table=11
FT                   /gene="acaB"
FT                   /product="acetyl CoA synthase"
FT                   /db_xref="GOA:Q51797"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="UniProtKB/TrEMBL:Q51797"
FT                   /protein_id="CAA59498.1"
FT                   /translation="MRKAIIVGVGMTPVGEHWRSSLRDLAVEAILNAMDDAGIDKVDSL
FT                   YVGNMASGSFVEQENLGALIADWAGLGNIPAVKIEAACASGGAAVQEGAKAVLSGLEDV
FT                   VLVVGVEKMTDAWPSDATRYLGYAADAEWELFHGASFVALNALIMRLYMNTYGYKEEDL
FT                   ALFAVNAHANGAKNPYAMFKKPITVETVMKSPYIADPLKLFDASPVCDGAAAVIITTPE
FT                   KAKELGIPKDKWIEIAGMGRAIDTINLANREDFLTLKAATIAAERAYKMAGVKPEDVDF
FT                   FEVHDAFTVMAALSLEALGVAKKGEGAKLAIEGQIAIDGDYPIQTMGGLKARGHPVGAT
FT                   GVYQVVEAVLQLRGEAPDGIQVPDAEVGLTQNIGGTGSNITVTVLRRV"
FT   RBS             complement(2265..2270)
FT                   /gene="acaB"
FT   CDS             complement(2272..3324)
FT                   /transl_table=11
FT                   /gene="acaA"
FT                   /product="acyl carrier protein synthase"
FT                   /db_xref="GOA:Q51798"
FT                   /db_xref="HSSP:1HNK"
FT                   /db_xref="InterPro:IPR016038"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51798"
FT                   /protein_id="CAA59499.1"
FT                   /translation="MRKVMKPMKDVGIVGYGAYVPMYRIRNEEIGRVWGVSSFPIEEKA
FT                   VPGLDEDAITIGIEAARNALKRAKIDPQKIRAIWFGTESKPYAVKPSATIIAEAIGATP
FT                   DLEAADFEFACKAGTEALQAAIGFVGSGMAEYAMAIGADTAQGRPGDHLEFTAGAGGAA
FT                   FIVGEKSNESVAYFEGSYSYVTDTPDFWRRQHEHYPRHGNRFTGEPAYFHHIINAAKTL
FT                   MEELGLKPSDFDYAVFHQPNVKFPLTVAKILGIPKEKVLPGLLTGRIGNTYSGATMVGV
FT                   SAVLDIAKPGDRILWVSFGSGAGSNAFSIVVQDAIEEKRDLAPKVEDYVKRRKVIDYAL
FT                   YAKARRKYIL"
FT   RBS             complement(3328..3333)
FT                   /gene="acaA"
FT   promoter        complement(3374..3381)
FT                   /note="Box A promoter sequence for aca operon"
FT   promoter        3491..3498
FT                   /gene="porG"
FT                   /note="BoxA promoter for aca operon"
FT   RBS             3550..3555
FT                   /gene="porG"
FT   CDS             3563..4120
FT                   /transl_table=11
FT                   /gene="porG"
FT                   /product="pyruvate ferredoxin oxidoreductase"
FT                   /db_xref="GOA:Q51799"
FT                   /db_xref="InterPro:IPR019752"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51799"
FT                   /protein_id="CAA59500.1"
FT                   /translation="MIEVRFHGRGGQGAVTAANILAEAAFLEGKYVQAFPFFGVERRGA
FT                   PVTAFTRIDNKPIRIKTQIYEPDVVVVLDPSLLDAVDVTAGLKDEGIVIVNTEKSKEEV
FT                   LEKLKKKPKKLAIVDATTIALEILGLPITNTAILGAVAKATGLVKIESIEEAIKDTFSG
FT                   ELGEKNARAAREAYEKTEVFEL"
FT   promoter        4115..4120
FT                   /gene="VOR-delta"
FT   terminator      4119..4133
FT                   /note="pyrimidine-rich putative transcriptional termination
FT                   signal for P/VOR-gamma"
FT   RBS             4147..4150
FT                   /gene="vorD"
FT   CDS             4157..4474
FT                   /transl_table=11
FT                   /gene="vorD"
FT                   /product="2-ketovalerate ferredoxin oxidoreductase delta-2"
FT                   /note="gtg start codon"
FT                   /db_xref="GOA:Q51800"
FT                   /db_xref="HSSP:2FDN"
FT                   /db_xref="InterPro:IPR011898"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51800"
FT                   /protein_id="CAA59501.1"
FT                   /translation="MNTLFGKTKEEAKPIVLKSVDEYPEAPISLGTTLVNPTGDWRTFK
FT                   PVVNEEKCVKCYICWKYCPEPAIYIKPDGYVAIDYDYCKGCGICANECPTKAITMIKEE
FT                   K"
FT   RBS             5663..5671
FT                   /gene="vorA"
FT                   /gene_synonym="vorB"
FT   CDS             4487..5671
FT                   /transl_table=11
FT                   /gene="vorA"
FT                   /product="2-ketovalerate ferredoxin oxidoreductase alpha-2"
FT                   /db_xref="GOA:Q51801"
FT                   /db_xref="HSSP:1KEK"
FT                   /db_xref="InterPro:IPR015941"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51801"
FT                   /protein_id="CAA59502.1"
FT                   /translation="MEYKPIRKVVSGNYAAAYAALHARVQVVAAYPITPQTSIIEKIAE
FT                   FIANGEADIQYIPVESEHSAMAACIGASATGARTFTATSAQGLALMHEMLHWAAGARLP
FT                   IVMVDVNRAMAPPWSVWDDQTDSLSQRDTGWMQFYAENNQEVYDGVLMAYKVAETVNVP
FT                   AMVVESAFILSHTYDVVEMIPQELVDEFLPPRKPLYSLANFDEPIAVGALATPNDYYEF
FT                   RYKLAKAHEEAKKVIKEVGKEFGERFGRDYSQMIETGYIDDADFVFMGMGSLMGTVKEA
FT                   VDLLRKEGYKVGYAKVRWFRPFPKEELVEIAESVKGIAVLDRNFSFGQEGILFTESKGA
FT                   LYNSSAHPLMKNYIVGLGGRDVTVKDIKAIADDMKKVIESGKVDKEVVWYHLKR"
FT   CDS             5677..6612
FT                   /transl_table=11
FT                   /gene="vorB"
FT                   /product="2-ketovalerate ferredoxin oxidoreductase beta-2"
FT                   /db_xref="GOA:Q51802"
FT                   /db_xref="HSSP:1KEK"
FT                   /db_xref="InterPro:IPR011766"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51802"
FT                   /protein_id="CAA59503.1"
FT                   /translation="MEVPENIKKRVTIPFEEHFYAGHTACQGCGASLGLRYVLKAYGKK
FT                   TILVIPACCSTIIAGPWPYSAIDANLFHTAFETTGAVISGIEAALKAMGYKVKGEDGIM
FT                   VVGWAGDGGTADIGLQALSGFLERGHDAVYIMYDNEAYMNTGIQRSSSTPYGAWTTNTP
FT                   GGRRHFLEKRHKKKVIDIVIAHRIPYAATASIAYPEDFIRKLKKAQKISGPSFIQLFAP
FT                   CPTGWRAPTDKSIEIARLAVQTAYFPLFEYENGKYKINMPNPKKEPKPIEEFLKLQGRF
FT                   KYMTKEDIETLQKWVLEEWERLKKLAEVFG"
FT   promoter        6615..6620
FT                   /gene="por"
FT   terminator      6626..6636
FT                   /gene="vor"
FT                   /note="putative"
FT   RBS             6650..6656
FT                   /gene="porD"
FT   CDS             6661..6978
FT                   /transl_table=11
FT                   /gene="POR-delta"
FT                   /product="pyuvate ferredoxin oxidoreductase"
FT                   /db_xref="GOA:Q51803"
FT                   /db_xref="HSSP:1CLF"
FT                   /db_xref="InterPro:IPR011898"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51803"
FT                   /protein_id="CAA59504.1"
FT                   /translation="MAESPFKADIERAQKELSEKMTPGAIVYIPGSSVINKTGSWRVFK
FT                   PEFNRDKCVRCYLCYIYCPEPAIYLDEEGYPVFDYDYCKGCGICANECPTKAIEMVREV
FT                   K"
FT   RBS             6977..6982
FT                   /gene="porA"
FT   CDS             6989..8179
FT                   /transl_table=11
FT                   /gene="porA"
FT                   /product="pyruvate ferredoxin oxidoreductase alpha-2"
FT                   /db_xref="GOA:Q51804"
FT                   /db_xref="InterPro:IPR015941"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51804"
FT                   /protein_id="CAA59505.1"
FT                   /translation="MPIRKVMKANEAAAWAAKLAKPKVIAAFPITPSTLIPEKISEFVA
FT                   NGELDAEFIKVESEHSAISACVGAAAAGVRTFTATASQGLALMHEILFIAAGMRLPIVM
FT                   AIGNRALSAPINIWNDWQDTISQRDTGWMQFYAENNQEALDLILIAYKVAEDERVLLPA
FT                   MVGFDAFILTHTVEPVEIPDQEVVDEFLGEYEPKHAYIDPARPITQGSLAFPAHYMESR
FT                   YTVWEAMERAKKVIDEAFAEFEKKFGRKYQKIEEYKTEDADIIFVTMGSLAGTLNEWID
FT                   KKREEGYKVGAAKITVYRPFPVEEIRELAKKAKVLAFLEKNITIGLYGAVFTDASAALI
FT                   NESEKPLMVDFIVGHGGRDVTFNQLDEALEIAEKALKEGKVENPINWIGLRWELVK"
FT   RBS             8178..8185
FT                   /gene="porB"
FT   CDS             8190..9185
FT                   /transl_table=11
FT                   /gene="porB"
FT                   /product="pyruvate ferredoxin oxidoreductase beta-2"
FT                   /db_xref="GOA:Q51805"
FT                   /db_xref="HSSP:1KEK"
FT                   /db_xref="InterPro:IPR011766"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q51805"
FT                   /protein_id="CAA59506.1"
FT                   /translation="MAVRKPPITTREYWAPGHAACAGCGCATALRLATKALSEAMEEKY
FT                   GDPNAFAIAHATGCMEVVSAVFPYTAWKAPWIHVAFENAAAVASGIEAAWKKLGRKGKI
FT                   LAIGGDGGTADIGLQALSGMLERWHNVLYLMYDNEAYMNTGIQRSSSTPYGAWTTTSPP
FT                   GKYSVGEDKPKKWVALIAAAHQIPYVATASIGNPLDFVRKIKKAGKIDGPAFVQVLCTC
FT                   PTGWRSPLEKGVEIARLAIETGIWPLFEIENGDIWNIKIQPPGGGAKVYKEGNRVVRIE
FT                   FKKPIEEYLKLQGRFKHLFKRPEAIEELRNQVKAMWKVLGVEAILPRPEE"
FT   terminator      9190..9208
FT   terminator      9215..9230
FT   promoter        9205..9210
FT                   /gene="ORFZ"
FT   CDS             9235..>9585
FT                   /transl_table=11
FT                   /gene="ORFZ"
FT                   /db_xref="UniProtKB/TrEMBL:Q51806"
FT                   /protein_id="CAA59507.1"
FT                   /translation="MRIAIMTSDPRVYYLASKVLKEHKIPFYSLTPTDEIPFDVEVILT
FT                   GEKDFDKIKFPNKIIVRDETFIDELLLFLEGKKRFKSVFIAIDPGERPGVSVVADNRVL
FT                   EVYHLKSPKDVDI"
XX
SQ   Sequence 9585 BP; 2921 A; 2067 C; 2028 G; 2569 T; 0 other;
     gatatcataa ttgctataga gtaaagcaag actttagtcg catctatttt aacattccca        60
     gttctcactc ccattaggaa gattaaaaca agaacagata cactcataag aagttccgta       120
     tcaattttct tcctcctttc tctaagaatg tacccaataa taattcccag gaggagcggg       180
     attaaaatat tcaccttact caccttccct aattattgac aatattagtt ccatagctct       240
     tggaattgct cgcttaactt cttcacttaa ctctaggccc aattttggtt cctttatcgt       300
     aaccccaaca aaatgaagtt cagcgttctt aagtctttcg tcaacctcta acagtaattt       360
     taacccctca actgccccca taaagtgagc acttctaatt tctgccctta acttcttgaa       420
     aatatcctct cctttaaagt agacgacctt acctgggatc tctccaagaa cagcatctac       480
     tataattact ttattctccc cgttataaac cctcatgaga gagaaaatat cagttccaag       540
     ttcttctact ttgtaccctt gccttttcaa ttctctcccg attttaatcc ctactccatc       600
     gtctcccatg acttcatttc ccaatgcaac aataagaact gaagacatca aaaaaggaat       660
     aaagtgaaag tttaaaaagt tactcactct ttatgatggg tctaaactta tatccataga       720
     gaattagccc atcttcgtca aattctctga tctttcttgt taccatctcc acttccattc       780
     cttctttgat ttcttcaggc tctacgtctg taagttgagc caatacaacg ggcccttcct       840
     caagctgaac taaagccaat gggtagggtt tgtagtactc aaagccactt ggagggtttc       900
     tgactatagt ccatgttata actttcccct tgccactaaa ctgaaattct tcaatgtttc       960
     tacttccaca aattgggcag attggtctct tggggaatag aaggtggcca ttttcacact      1020
     ttccacctat aagtctgtat ttctccctaa agtgtctcca atacctggaa acctgcatcg      1080
     gcttccccat ttcagaccct cctcaaaaca gtaacggtga tatttgatcc agtacctcca      1140
     atattctgag ttaatcccac ttcagcatcg ggaacttgaa tcccatcagg agcctctcct      1200
     cttagctgga gaacagcctc tacaacctga taaaccccag tagctcctac tgggtgacct      1260
     cttgctttca atccacccat tgtttggatt ggataatccc cgtcaattgc tatttgaccc      1320
     tcaattgcga gtttagctcc ttcgcccttc tttgcaactc ccagcgcctc tagacttaat      1380
     gctgccataa ctgtaaatgc atcgtggacc tcaaagaagt caacatcctc aggcttaact      1440
     ccggccatct tataagctct ttctgctgca attgtagctg cttttaaagt taggaaatct      1500
     tctctattgg ccagatttat tgtgtcaata gcccttccca ttcctgcaat ctcaatccat      1560
     ttgtcctttg gaataccaag ctctttagcc ttctctggtg tggtaattat aactgctgca      1620
     gcaccgtcac aaactggaga tgcatcgaag agcttaagtg gatcagcaat gtagggactc      1680
     ttcataactg tttcaactgt tattggcttc ttaaacattg catagggatt ctttgcacca      1740
     tttgcgtgag cattaactgc aaatagtgcc aaatcctcct ccttataccc gtaagtgttc      1800
     atgtaaagtc tcattataag agcattcaaa gctacaaagc tggcaccatg gaagagctcc      1860
     cactcagcat cagcggcata tcccaagtat ctcgtagcat cactaggcca agcatctgtc      1920
     atcttctcta ctccaacgac taaaactaca tcttcaagac cactaagcac agctttagca      1980
     ccttcttgaa ctgcagctcc accagaagca caagcagctt caattttaac ggcaggaata      2040
     ttccccaatc cagcccaatc agctattaat gctcccaggt tttcttgctc tacgaatgaa      2100
     ccagatgcca tgttaccaac atatagagaa tcaactttgt caattcccgc atcatccatc      2160
     gcgtttaaaa ttgcttcgac ggctaaatcc ctaagagaag acctccaatg ttctccaaca      2220
     ggagtcattc caactccaac tattattgct tttctcatat ctcccacccc tctacaagat      2280
     gtactttctt ctagcctttg catagagagc gtaatcaatg acttttctcc tcttcacata      2340
     atcctcaact tttggcgcta aatctctctt ctcctctatg gcatcctgaa caactatact      2400
     aaatgcattg cttcctgctc cagaaccaaa cgagacccag agaattctat ccccgggctt      2460
     tgctatgtcc aaaacagcag aaactccaac cattgttgca ccgctgtatg tatttcctat      2520
     tctccctgtt agcaatcccg gtagaacttt ctctttagga atcccaagaa tcttagcaac      2580
     tgtcaatggg aactttacat ttggttggtg aaatactgca taatcaaagt cacttggctt      2640
     aaggcctaac tcttccataa gggtcttggc tgcattaatt atatggtgga agtatgctgg      2700
     ctccccagta aacctgtttc catgcctggg gtagtgttca tgttgccttc tccagaaatc      2760
     gggagtgtct gtaacgtaag agtagctccc ctcaaaatat gctacactct cattgctctt      2820
     ttctcccaca atgaaagctg ctcctcctgc cccagctgtg aactctaagt gatctccggg      2880
     ccttccctgg gcagtgtcag cacctatggc cattgcatac tcagccatgc ccgaacctac      2940
     aaaacctatg gcagcttgca gagcctcagt gccagcctta caagcgaatt caaaatcagc      3000
     agcttcaaga tctggagttg caccaatagc ttcagctatt attgtagctg aaggctttac      3060
     tgcatagggc ttactttcag taccaaacca aatggccctt attttttgag gatctatctt      3120
     agctctcttt aaggcgtttc tagcagcttc tattcctatc gttatagcgt cttcatcaag      3180
     cccaggtaca gccttttctt ctatcggaaa gcttgagacc ccccatactc ttcctatttc      3240
     ttcattcctt atcctataca ttggcacgta tgctccatac ccaacaatac caacgtcttt      3300
     cattggcttc attacctttc tcatttaacc tccccctggg aattactgtg tcacctacta      3360
     gaaaaaggag gagttataaa agactttcgg taaaagctta actttatttc gttcatcgtc      3420
     gataaaacaa tattaatatt gtaaaccaag ggttttgcaa ttgacgtgaa agttttcggg      3480
     acacaccgaa aattaaataa actaattttc tttaaccaaa aatgcccgta attaaattca      3540
     aaaattttaa ggaggtttga agatgataga agttcgcttt cacggtagag gaggtcaagg      3600
     tgcagttacc gctgcaaaca ttcttgctga agcagcgttt ctagaaggta aatacgtgca      3660
     ggctttccca ttctttggag ttgaaagaag aggagctcca gtaacagctt tcacaaggat      3720
     agacaacaaa ccaattagga taaagactca aatttatgaa cccgacgttg ttgttgtgct      3780
     agatccctct ctcttagatg ctgtagacgt aactgctggt cttaaagatg agggaattgt      3840
     catagtgaat acagaaaaga gcaaagaaga agttctcgaa aagttaaaga aaaagccaaa      3900
     gaagctcgct atagttgatg caactacgat agctcttgaa attcttggat tgcccattac      3960
     gaatactgcc atattgggag ctgttgcaaa ggccacaggg ctagtcaaga ttgagagcat      4020
     agaggaagcc atcaaagaca cattctctgg ggagcttggt gaaaagaacg caagggctgc      4080
     aagagaagct tacgaaaaaa cagaagtatt tgagctttaa cctctttctt tccaatattt      4140
     gatgaggtga gaagttgtga acactctatt tggaaaaacc aaagaagaag caaaacctat      4200
     agttctaaaa tctgttgacg agtaccctga agctcctata agcctcggaa ctactttggt      4260
     taaccccacc ggagattgga gaacatttaa gcctgttgtt aatgaagaga aatgtgtaaa      4320
     atgttatatt tgttggaaat actgtccaga gcctgcaatt tacataaaac ccgacggata      4380
     cgttgcaatt gactacgact attgtaaggg ttgtggaatc tgtgctaatg agtgcccaac      4440
     taaagcaatt acaatgatta aggaagaaaa gtagtgaggt gggaaaatgg aatataaacc      4500
     aattagaaaa gttgtgagtg gcaactatgc tgcagcttat gcagcccttc atgcgagagt      4560
     tcaagttgtt gccgcttatc ctattacccc tcaaaccagc atcattgaaa aaattgcaga      4620
     gtttatagcc aatggtgagg ctgacattca atatataccc gtcgaaagcg agcactctgc      4680
     tatggcagct tgtataggcg catcggctac tggagctaga acatttactg caacttctgc      4740
     tcagggatta gctctaatgc atgaaatgct tcattgggct gctggagcaa ggcttccaat      4800
     tgttatggtt gatgtaaaca gagcaatggc tccaccttgg agtgtgtggg atgatcaaac      4860
     tgattctctc tcacaaagag acactgggtg gatgcagttc tacgctgaaa acaaccaaga      4920
     agtttacgac ggtgtcctaa tggcatacaa agttgcagag acagtcaacg ttcccgcaat      4980
     ggtagttgag agcgcattta ttctcagcca cacatatgac gtcgttgaaa tgattccaca      5040
     ggaacttgtt gacgagtttt taccaccaag gaagcccttg tatagcttag caaacttcga      5100
     tgagcccata gcggtaggag cccttgcaac accaaacgat tactatgagt ttagatataa      5160
     gttagctaag gctcatgaag aggccaaaaa agtcattaag gaagtcggaa aagaatttgg      5220
     agagcgcttt ggtagagact atagtcaaat gattgagaca ggctacatcg atgatgcaga      5280
     cttcgtattt atgggtatgg gttccctaat gggtaccgta aaggaagcag tcgacctctt      5340
     aagaaaagaa ggttataaag taggatacgc aaaagttaga tggtttagac cattcccgaa      5400
     ggaagagcta gtagaaattg cggagagcgt taagggaata gccgttcttg atagaaactt      5460
     ctcctttgga caagagggaa ttctcttcac ggagagcaag ggcgcgctct ataactcttc      5520
     agctcaccca ttgatgaaga actatatagt tggccttgga ggaagggatg ttactgtaaa      5580
     agacattaag gcaatagcag atgatatgaa gaaagtcatt gagagtggaa aagtggataa      5640
     agaagttgtt tggtaccatc ttaagaggtg agagttatgg aagttcccga gaatattaag      5700
     aagagggtaa cgatcccgtt tgaagagcac ttttatgctg gccataccgc ttgccaggga      5760
     tgtggggctt ccctcggact tagatatgtg ctgaaagctt atggaaaaaa gaccatccta      5820
     gtaattccag cttgttgttc gaccatcata gctggtccct ggccttactc cgcaatagat      5880
     gctaacttat tccacacagc ctttgaaaca acaggagcgg tgataagtgg aattgaagct      5940
     gcactaaagg ctatgggata caaggtaaag ggagaagacg ggataatggt cgttggatgg      6000
     gcaggagacg gtggtactgc cgacattggt cttcaagccc tctctggatt cttggagaga      6060
     ggtcacgatg cggtgtacat aatgtacgat aatgaggcct acatgaatac tggaattcag      6120
     aggtcttcat caactccata tggagcatgg accacaaata ccccaggagg aaggagacac      6180
     ttcctagaga agaggcataa gaagaaggtt attgacattg taattgccca tagaattcca      6240
     tatgccgcaa ctgccagtat agcttatcct gaggacttca ttagaaaact taagaaggct      6300
     caaaagattt caggtccaag tttcatccag ctcttcgctc cctgtcccac tgggtggaga      6360
     gcaccaacag acaagtcaat agaaattgca cgcttggcag ttcaaactgc atacttccca      6420
     ctcttcgaat atgaaaatgg caagtataag attaatatgc caaatcccaa aaaagaacca      6480
     aagccaattg aagaattcct gaagctccag ggaagattta aatacatgac aaaagaagat      6540
     attgagacac ttcaaaaatg ggtattggaa gaatgggaaa ggctaaagaa gcttgccgag      6600
     gtctttggat gacctatatg cttaaatttt tattttgaaa cctcactcga ggtggtaaat      6660
     atggctgaaa gtccgtttaa ggccgatata gaaagagccc aaaaagagtt aagtgaaaaa      6720
     atgacacccg gagcaatagt ctacattcca ggaagtagcg tcattaataa aactggatct      6780
     tggagagttt ttaagccaga gttcaacagg gacaagtgtg taaggtgtta tctctgctac      6840
     atctactgtc cagagcctgc aatataccta gatgaagaag gttacccagt ttttgactac      6900
     gactattgta agggttgtgg aatctgtgct aatgagtgtc caacaaaagc cattgaaatg      6960
     gttagagaag ttaagtgagg tggtttagat gccaattagg aaagttatga aggctaatga      7020
     agccgctgct tgggctgcta agttggctaa accaaaggtt atagcagcat tcccaattac      7080
     accttcaacc ctaatacccg agaagattag tgaattcgtg gcaaatggtg aactagacgc      7140
     agagtttatt aaagttgaaa gtgagcactc agcaatttca gcatgtgtag gtgcggctgc      7200
     tgcaggtgtt agaaccttca cagcaacagc ctctcaaggt ttggctttaa tgcacgaaat      7260
     tctattcatt gctgctggca tgagattgcc aattgtaatg gcaattggta acagagcttt      7320
     gtcagctcca attaacatct ggaatgactg gcaagacaca attagccaaa gagatactgg      7380
     atggatgcag ttctatgcag aaaacaacca agaggctcta gacttgatcc taatagctta      7440
     caaagttgca gaagatgaaa gagtcctcct tccagccatg gttggattcg atgcattcat      7500
     cctaacccat acagttgaac cagtagaaat cccagaccaa gaggttgttg atgaattcct      7560
     aggagaatac gagcccaagc acgcatatat tgatcccgca aggcctataa ctcaaggaag      7620
     ccttgcattc ccggcccact atatggagag cagatacaca gtttgggagg ctatggagag      7680
     agcaaagaag gtaatagacg aagcatttgc agaattcgag aagaagttcg gaagaaagta      7740
     ccagaagatt gaggagtaca agacagagga tgcagacata atcttcgtaa caatgggttc      7800
     actggctgga acccttaacg agtggataga caagaagaga gaggaaggtt acaaagttgg      7860
     tgcagcaaag ataaccgttt ataggccatt cccagtagaa gagataagag aactagcaaa      7920
     gaaggcaaag gttctcgcat tcctagagaa gaacatcaca atcggccttt atggtgcagt      7980
     ctttacggat gcatcagcag ctctcatcaa cgagagcgaa aagccactaa tggtcgactt      8040
     catagttggc catggtggaa gagatgtaac cttcaaccag cttgacgaag ccctggaaat      8100
     tgcagagaag gcactcaagg aaggtaaagt tgagaatcca attaactgga ttggattaag      8160
     atgggaactt gtgaagtgag gtgattgaga tggcagttag aaagccccca ataactaccc      8220
     gtgaatattg ggctcctggt catgccgcat gtgcaggttg tgggtgtgct actgctctaa      8280
     ggttagctac caaggctctt agtgaagcta tggaagagaa atatggagat ccaaacgcct      8340
     tcgcaatagc tcacgcaact ggctgtatgg aagtagtgtc agctgtattc ccatatacag      8400
     catggaaggc cccctggatt cacgtagctt ttgaaaacgc tgcagccgta gcgagtggta      8460
     ttgaagctgc atggaagaag cttggaagga aaggtaagat attggcaata ggtggagatg      8520
     gtggtacagc tgatatagga ctccaagccc tctctggaat gctcgaaaga tggcacaatg      8580
     ttctctacct tatgtatgac aatgaggctt acatgaacac tggaattcag aggtcttcat      8640
     caacaccata tggagcatgg accacaactt cacctcccgg aaagtattca gtaggtgaag      8700
     acaagccaaa gaagtgggta gcacttattg cagccgctca tcaaattccc tatgtagcaa      8760
     ctgcaagcat aggaaatcca cttgacttcg tgagaaagat aaagaaagca ggcaagattg      8820
     acgggccagc attcgttcaa gtcctctgta cttgtccgac aggatggaga agtccactgg      8880
     aaaaaggcgt tgagatagca aggctagcca tagaaacagg tatatggcca ctcttcgaga      8940
     ttgaaaatgg tgacatctgg aacattaaga tacagccccc aggaggagga gctaaggttt      9000
     acaaggaagg caacagagtc gttagaatag agttcaagaa gccaatcgag gagtacctca      9060
     agctccaagg aagattcaag cacctcttca agagaccaga ggccattgaa gagcttagga      9120
     accaagtaaa agcaatgtgg aaagtcttag gagttgaagc aatacttcca agacccgagg      9180
     agtagcctct ttttccatta tcttttttaa cctattaatt atttcctttt attgatgcga      9240
     attgcgataa tgacaagtga cccaagagtg tactatttag catcaaaggt tctcaaggag      9300
     cataagatac cattttatag tctaaccccc acagatgaaa tacccttcga cgtagaagtt      9360
     attctaacag gagagaaaga ctttgacaag ataaagttcc caaacaaaat aatagttagg      9420
     gatgagactt tcatagatga acttttgctg tttcttgaag gaaaaaagag gttcaaatcc      9480
     gttttcatag ccatagaccc aggagagcgg cctggagtta gtgttgttgc tgacaatagg      9540
     gttttggaag tatatcacct aaagagccca aaagatgtag atatc                      9585
//


  
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