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EBI DbfetchID X73308; SV 1; linear; genomic DNA; STD; PRO; 10932 BP. XX AC X73308; XX DT 24-JUN-1993 (Rel. 36, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 13) XX DE B.caldolyticus pyrimidine biosynthesis genes XX KW aspartate transcarbamoylase; carbamoyl-phosphate synthase; dihydroorotase; KW dihydroorotase dehydrogenase; omp decarboxylase; ORF2; KW orotate phosphoribosyltransferase; pyrAA gene; pyrAB gene; pyrB gene; KW pyrC gene; pyrD gene; pyrE gene; pyrF gene; pyrimidine biosynthesis. XX OS Bacillus caldolyticus OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. XX RN [1] RX PUBMED; 7516791. RA Ghim S.Y., Nielsen P., Neuhard J.; RT "Molecular characterization of pyrimidine biosynthesis genes from the RT thermophile Bacillus caldolyticus"; RL Microbiology (Reading, Engl.) 140:479-491(1994). XX RN [2] RP 1-10932 RA Neuhard J.; RT ; RL Submitted (08-JUN-1993) to the EMBL/GenBank/DDBJ databases. RL J. Neuhard, University of Copenhagen, Dept of Biological Chemistry, Inst of RL Molecular Biology, Solvgade 83, 1307 Copenhagen, DENMARK XX RN [3] RC secondary RP 1-10932 RX PUBMED; 8206848. RA Ghim S.Y., Neuhard J.; RT "The pyrimidine biosynthesis operon of the thermophile Bacillus RT caldolyticus includes genes for uracil phosphoribosyltransferase and uracil RT permease"; RL J. Bacteriol. 176(12):3698-3707(1994). XX DR CABRI; DSM 405. DR RFAM; RF00515; PyrR. XX FH Key Location/Qualifiers FH FT source 1..10932 FT /organism="Bacillus caldolyticus" FT /strain="DSM405" FT /mol_type="genomic DNA" FT /db_xref="taxon:1394" FT CDS 396..1322 FT /transl_table=11 FT /gene="PyrB" FT /product="aspartate carbamoyltransferase" FT /EC_number="2.1.3.2" FT /db_xref="GOA:P41008" FT /db_xref="HSSP:1ML4" FT /db_xref="InterPro:IPR002082" FT /db_xref="UniProtKB/Swiss-Prot:P41008" FT /protein_id="CAA51736.1" FT /translation="MTHLFALSELPLDEIHRLLDEAERFRSGRIWRPAAPMYVANLFFE FT PSTRTKCSFEMAERKLGLHVIPFDPERSSVQKGETLYDTVRTLEAIGVDAVVIRHHEDA FT YFEALRHAVGIPIINAGDGCGHHPTQSLLDLLTIRQEFGAFTGLTVAIIGDIRHSRVAR FT SNAEVLTRLGANVLFSGPEEWKDETNPYGTYVEVDEAIARADVVMLLRIQHERHAETMG FT LTKEEYHARYGLTLERARRMKSGAIILHPAPVNRGVEIASELVEAKASRIFKQMENGVY FT VRMAVLKRAMEGRMEHGRMAEKWHVVQ" FT CDS 1285..2568 FT /transl_table=11 FT /gene="PyrC" FT /product="dihydroorotase" FT /EC_number="3.5.2.3" FT /db_xref="GOA:P46538" FT /db_xref="HSSP:1GKR" FT /db_xref="InterPro:IPR002195" FT /db_xref="UniProtKB/Swiss-Prot:P46538" FT /protein_id="CAA51737.1" FT /translation="MGVWLKNGMSFNKDGELMRTHIKIEHGTIAAILYEQPLEANEDVI FT DVGGRLIVPGLIDLHVHLREPGGEAKETIETGTLAAAKGGFTTVAAMPNTNPAPDRKEQ FT MEWLQARIRETARVNVLPYAAITIGQKGEELTDFAALKEAGAFAFTDDGVGVQSAGMMF FT EAMKQAAALDMAIVAHCEDDTLTNGGAVHDGEFARRYGLRGIPSVCEAVHIARDVLLAE FT AAGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVTPHHLLLCDEDIPGLDANYKMNPPL FT RSREDRDALIEGLLDGTIDFIATDHAPHTAAEKAKGIEAAPFGIVGLETAFPLLYTHFV FT KTGVFTLKQLVDWLTIKPAQCFGLKAGRLAVGAPADIAVIDLETEEAIDPETFASKGKN FT TPFAGWVCQGWPVMTFVGGTLVWEKGRA" FT CDS 2571..3665 FT /transl_table=11 FT /gene="PyrAa" FT /product="carbamoyl-phosphate synthase FT (glutamine-hydrolysing)" FT /EC_number="6.3.5.5" FT /db_xref="GOA:P52557" FT /db_xref="HSSP:1A9X" FT /db_xref="InterPro:IPR000991" FT /db_xref="UniProtKB/Swiss-Prot:P52557" FT /protein_id="CAA51738.1" FT /translation="MKRQLILEDGSFFVGERFGSLKETTGEVVFNTGMTGYQEILSDPS FT YCGQIVTMTYPLIGNYGINRDDFEAIRPHVHGFIVKEACVKPSNWRGELTLDEYLKEKG FT IPGLSGIDTRKLTRLIRQYGTLKGMICGLDVDPVEAAAKLRAMEWPRDQVRRVSTKSAY FT PSPGRGERIVLIDFGMKHGILRELNKRNCDVIVLPYNATAEEVLGWHPDGVMLSNGPGD FT PKDVPEAIEMIRGILGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKDLRTGK FT VAITSQNHGYTVTHESLSGTRLEVTHIALNDGTVEGLRHLDVPAFTVQYHPEASPGPED FT ANPLFDEFLALIREFNKKGEVIHA" FT CDS 3658..6855 FT /transl_table=11 FT /gene="PyrAb" FT /product="carbamoyl-phosphate synthase FT (glutamine-hydrolysing)" FT /EC_number="6.3.5.5" FT /db_xref="GOA:P46537" FT /db_xref="HSSP:1CS0" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:P46537" FT /protein_id="CAA51739.1" FT /translation="MPKRRDIETILVIGSGPIVIGQAAEFDYAGTQACLALKEEGYKVI FT LVNSNPATIMTDTEIADKVYMEPLTLDFVARIIRKERPDAILPTLGGQTGLNLAVELAK FT AGVLEECGVEILGTKLEAIEKAEDREQFRALMNELGEPVPESAIIHSLEEAYAFVEQIG FT YPVIVRPAFTLGGTGGGICTNEEELVEIVSTGLKLSPVHQCLLERSIAGYKEIEYEVMR FT DANDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNASLKIIRALGIEGGC FT NVQLALDPDSFRYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMINPVTG FT KTYACFEPALDYVVTKIPRFPFDKFESANRRLGTQMKATGEVMAIGRTFEESLLKAVRS FT LEIGVHHLELNEAKTAADDVMEKRIRKAGDERLFYIAEALRRGVTVETLHEWSQIDRFF FT LHKIQNIIEMETVLKNHPGDLDVLKKAKGLGFSDAAIAALWNKTERDIYAVRRQRGIMP FT VYKMVDTCAAEFTSETPYYYSTYEEENESIVTEKPSVIVLGSGPIRIGQGIEFDYATVH FT CVWAIKQAGYEAIIINNNPETVSTDFSTSDKLYFEPLTAEDVMHVIDLEQPIGVIVQFG FT GQTAINLAAELEARGVRLLGTTLEDLDRAEDRDKFEQALSELGIPKPAGKTAVSVEEAV FT AIAEEIGYPVLVRPSYVLGGRAMEIVYNRGELLHYMEHAVRVNPQHPVLVDRYITGKEV FT EVDAIADGETVVIPGIMEHIERAGVHSGDSIAVYPPQTLSAEVIDKIADYTIRLARGLH FT IVGLLNIQFVVSGSDVYVLEVNPRSSRTVPFLSKITGVPMANLATKAILGTKLAEMGYE FT TGVCPVRPGVYVKVPVFSFAKLRNVDISLGPEMKSTGEVIGKDVTFEKALYKGLVASGI FT HIQPHGAVLLTVADKDKEEAVELARRFADIGYQLLATNGTAETLKAAGIPVTVVNKIHS FT ASPNILDVIRQGKAQVVINTLTKGKQPESDGFRIRREAVENGIPCLTSLDTARAMLQVL FT ESMTFSTTAMTEGLVRS" FT CDS 6852..7625 FT /transl_table=11 FT /note="ORF2" FT /db_xref="GOA:P46536" FT /db_xref="HSSP:1EP3" FT /db_xref="InterPro:IPR001433" FT /db_xref="UniProtKB/Swiss-Prot:P46536" FT /protein_id="CAA51740.1" FT /translation="MIGRERMTVASQRLIAERTYELTLSGRLVQEMRQPGQFVHVKVAA FT SADPLLRRPLSLCHIDHKQGQCTIIYRQEGKGTALLAQKQPGDTVDVLGPLGNGFPLEA FT APAGSRALLVGGGIGVPPLYELAKQLTKRGVKVVSVLGFQTKAAVFYEEEFAAFGETHV FT ATDDGSHGTAGRVTDVIEARSLEFDVLYACGPKPMLRALAERFPNRPVYLSLEERMGCG FT VGACFACVCHVPGSETAYKKVCSDGPVFRAGEVVL" FT CDS 7622..8563 FT /transl_table=11 FT /gene="PyrD" FT /product="dihydroorotate oxidase" FT /EC_number="1.3.3.1" FT /db_xref="GOA:P46539" FT /db_xref="HSSP:1EP2" FT /db_xref="InterPro:IPR001295" FT /db_xref="UniProtKB/Swiss-Prot:P46539" FT /protein_id="CAA51741.1" FT /translation="MNRLAVELPGLSLKNPIMPASGCFGFGREYARFYDLSVLGAIMIK FT ATTKEPRFGNPTPRVAETPGGMLNAIGLQNPGLDKVLEEELPWLEQFDVPIIANIAGST FT VEEYVEVAEAISKAPNVHALELNISCPNVKKGGIAFGTVPDVAAELTRLVKEVAAVPVY FT VNVSPNVTDIVAMAKAIEQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKP FT IAIRMIYEVSQAVSIPIIGMGGIQTAEDVLEFFYAGASAVAVGTANFVDPFVCPTIIAD FT LPALLDDLGIGHISECIGRSWKTGAHAVHCRA" FT CDS 8535..9269 FT /transl_table=11 FT /gene="PyrF" FT /product="orotidine-5'-phosphate decarboxylase" FT /EC_number="4.1.1.23" FT /db_xref="GOA:P46535" FT /db_xref="HSSP:1DBT" FT /db_xref="InterPro:IPR014732" FT /db_xref="UniProtKB/Swiss-Prot:P46535" FT /protein_id="CAA51742.1" FT /translation="MHTPFIVALDFPSKQEVERFLRPFAGTPLFVKVGMELYYQEGPAI FT VAFLKEQGHAVFLDLKLHDIPNTVKQAMKGLARVGADLVNVHAAGGRRMMEAAIEGLDA FT GTPSGRMRPRCIAVTQLTSTDERMLHEELWISRPLAETVAHYAALAKESGLDGVVCSAN FT EAAFIKERCGASFLAVTPGIRFADDAAHDQVRVVTPRKARALGSDYIVVGRSLTRAADP FT LGAYARLQHEWNGGERESTTPT" FT CDS 9654..10274 FT /transl_table=11 FT /gene="PyrE" FT /product="orotate phosphoribosyltransferase" FT /EC_number="2.4.2.10" FT /db_xref="GOA:P46534" FT /db_xref="InterPro:IPR000836" FT /db_xref="UniProtKB/Swiss-Prot:P46534" FT /protein_id="CAA51743.1" FT /translation="MKHDIAAKLLQIGAVALQPNEPFTWSSGLKSPIYCDNRLTLAYPG FT VRRLIADALAELIRTHFPKADLIAGTAAGIPHAAWVSERLELPMCYVRSQAKRHGKGKQ FT IEGQARPGQRVVVIEDLISTGGTSLAAVRALKEAGCEVLGVAAIFTYGLEKAKQAFAAE FT NLPAYTLTDYNTLIETAVRLGAVSEHDLATLRQWRENPEEWGS" XX SQ Sequence 10932 BP; 2484 A; 3035 C; 3311 G; 2102 T; 0 other; gatcgacagc cgcgtcgatt tcggccagac gcgcaattta gtcatcgcct cggtcatctt 60 ggtcatcggc atcggcggag cggtgctgaa aatcagcgac agcttccaaa ttaccgggat 120 ggcgctctcg gccattgtcg gcgtcctcct caacttgatt ttgccggggc gtccgcaagc 180 cgcggaaaac ctatttgaag aaaaccagag cgaccatgtc gcctaatagg agaaagcacc 240 ttttaattaa gtcccgcgag gcttaaaaag gtgtgaaaac aggcgcatcc agggccggag 300 tgcaccttct tcggctctgc catgcgccga tcgtcacacc ttgcctggcc ggcaaggtgt 360 tttttttcgc gaaaaaacga aaaggagcga gaccgatgac ccatcttttc gcattaagtg 420 aactgccgct tgatgaaatc caccgtttgc tcgatgaagc ggaacggttc cgcagcgggc 480 gcatctggcg cccggcggcg ccgatgtacg tcgccaactt gtttttcgaa ccgagcacgc 540 gcacgaaatg cagcttcgag atggcggaac ggaagcttgg gcttcatgtc atcccgtttg 600 acccggaacg ctcgagcgtg caaaaagggg agacgctgta cgataccgta cggacgcttg 660 aggcgatcgg cgtcgatgcg gttgtcatcc gccatcacga agatgcgtat ttcgaagcgc 720 tccgccatgc ggtcggcatt ccgatcatca acgccggcga cggctgcggg caccatccga 780 cccagtcgct cttggattta ttgacgatcc gtcaggagtt tggcgccttc actggcttga 840 cggtggcgat catcggcgac atccgccaca gccgcgtcgc tcgctccaat gcggaagtgt 900 tgacacgatt gggcgcgaac gtcctgtttt ccggaccgga agagtggaaa gatgaaacga 960 atccgtacgg gacgtacgtc gaagtcgacg aggccatcgc ccgcgccgat gtcgtgatgc 1020 ttttgcgcat ccaacatgaa cgccatgcgg aaacgatggg gctgacaaaa gaagagtacc 1080 atgcgcggta cgggctgacg cttgagcggg cgcggcggat gaaatcgggc gccatcatct 1140 tgcacccggc gccggtcaac cgcggggtcg aaatcgcaag cgaacttgtc gaagcgaagg 1200 catcgcgcat ttttaaacaa atggaaaacg gcgtctacgt ccggatggct gtcttaaaac 1260 gggcaatgga agggagaatg gagcatgggc gtatggctga aaaatggcat gtcgttcaat 1320 aaagatgggg aattgatgcg gacacatatc aaaatcgaac acggaaccat tgcagcgatc 1380 ctctatgaac agccgctgga agcgaatgag gacgttatcg acgttggcgg ccgtctcatc 1440 gttcctggcc tgatcgactt gcacgttcat ttgcgcgaac cgggcggcga agcgaaagaa 1500 acgattgaaa cgggcacgct cgccgcggcg aaaggcggat ttacgacggt tgctgccatg 1560 ccgaacacga acccagcgcc ggatcggaaa gagcagatgg aatggctgca agcccgcatc 1620 cgcgaaacgg cgcgcgtcaa cgtgcttccg tacgcggcga tcacgattgg gcaaaaaggg 1680 gaggagctga ccgattttgc ggcgctaaaa gaagcagggg cgttcgcctt taccgatgac 1740 ggcgtcggcg tccagtcggc cgggatgatg tttgaagcga tgaaacaggc ggcggcgctc 1800 gatatggcga tcgttgccca ttgcgaggac gacacgctga caaacggcgg agcggtgcat 1860 gacggcgagt tcgcccggcg ctatggactt cgcggcattc catccgtctg cgaggcggtg 1920 cacatcgccc gcgacgtctt gcttgccgag gcagccggat gccattatca cgtctgccat 1980 atcagcacga aagaatcggt gcgcgtcgtc cgcgacgcga agcgggccgg catccgcgtc 2040 accgccgaag tgacgccgca ccatctgctc ttgtgcgatg aggatattcc agggcttgat 2100 gcgaactaca aaatgaaccc accgctgcgc agccgagagg accgtgacgc attaattgaa 2160 ggactgctcg acggcacgat cgactttatc gccacggacc acgcgccgca tacggctgcg 2220 gaaaaagcga aaggcatcga ggcggcgccg tttggcatcg ttgggctcga aacggcgttt 2280 ccgctcttat atacccattt cgtcaaaaca ggcgtgttta cattaaagca gcttgtcgat 2340 tggctgacga tcaagccggc gcaatgtttc ggcctcaagg ccgggcggct tgccgtcggg 2400 gcgccggcgg atattgcggt cattgatttg gaaacagaag aagcgattga tcccgagacg 2460 tttgcgtcca aagggaaaaa tacgccgttt gccggctggg tgtgccaagg ctggccggtg 2520 atgacgtttg tcggcggtac actcgtatgg gagaaaggaa gggcgtaaag atgaaacggc 2580 agctgatttt agaagatggt tcgttttttg tcggcgaacg gtttggcagc ttgaaagaga 2640 cgaccgggga agtcgtcttt aacaccggca tgaccggata ccaagaaatt ttgtccgatc 2700 catcgtattg cgggcaaatc gtgacgatga catatccatt gatcggcaac tacggcatca 2760 accgcgacga ctttgaagcg atccgcccgc atgtgcacgg gttcatcgtc aaagaagcgt 2820 gcgtgaagcc gtccaactgg cgcggagaac tgacgttgga cgagtatttg aaagaaaaag 2880 gcatccctgg cctttccggc atcgacacgc gcaaactgac gcgccttatc cgccaatacg 2940 gaacgttaaa agggatgatc tgtgggctag atgtcgatcc ggtggaagca gcagccaagc 3000 tgcgggcgat ggagtggccg cgcgaccaag tgcggcgcgt ctcaacgaaa agcgcctacc 3060 caagcccggg gcgcggtgag cgcatcgtct tgattgattt cgggatgaaa cacggcattt 3120 tgcgcgaact gaacaagcga aattgcgatg tgatcgtctt gccgtacaac gccaccgctg 3180 aagaggtgct cggctggcat ccggatgggg tcatgctttc caatggaccg ggcgacccga 3240 aagacgtgcc ggaagcgatc gagatgatcc gcgggattct cggcaaagtg ccgctctttg 3300 gcatctgcct cggccatcag ctgttcgcgt tggcgtgcgg cgcgaatacc gagaaaatga 3360 aattcggcca tcgcggctcg aaccatccgg tcaaagactt gcgcaccggc aaagtcgcca 3420 tcacgtcgca aaaccatggc tataccgtca cgcacgagtc gctttctggc acccggcttg 3480 aggtgacgca tatcgcctta aatgacggca cggtcgaagg gctccgtcat ttggacgttc 3540 cggcgtttac ggtgcagtat catccggaag cgtcgccggg gccagaagat gccaatccgc 3600 tgtttgacga gtttttggcg ctcatccgcg agttcaacaa gaaaggagaa gtcatccatg 3660 cctaagcgcc gcgacattga aacgatttta gtcatcggct cggggccgat cgtcatcggc 3720 caggcggccg agttcgacta cgcagggacg caagcgtgct tagccctaaa agaagaagga 3780 tacaaagtca ttctggtgaa ctcaaacccg gcgacgatca tgaccgatac ggaaatcgcc 3840 gataaagtct atatggagcc gctgacgctc gattttgtcg cccgcatcat ccgcaaagag 3900 cggccggacg cgattttgcc gacgcttggc ggccaaacgg gcctcaactt ggcggttgag 3960 ctcgccaagg ccggcgtgct tgaagagtgc ggcgtggaaa ttctcggcac gaagctcgag 4020 gcgatcgaaa aggcggaaga ccgcgaacag ttccgcgccc tcatgaacga gcttggcgag 4080 ccggtgccgg aaagcgcgat tattcacagc ctggaagagg cgtatgcgtt tgtcgaacaa 4140 atcggctatc cggtcatcgt ccgccccgcg ttcacgctcg gcggcacggg cggcggcatt 4200 tgcacgaacg aagaagagct tgtcgagatt gtgtcaaccg gcctgaagct gagtccggtg 4260 caccaatgct tgcttgaacg gagcatcgcc ggctacaagg agattgaata cgaagtgatg 4320 cgcgacgcca acgacaacgc gattgtcgtc tgcaacatgg aaaacatcga tccggtcggc 4380 attcatacgg gtgactcgat cgtcgtcgcc ccgagccaga cgttaagcga ccgcgagtac 4440 cagctgctcc gcaacgcgtc gcttaagatc atccgcgcgc ttggcatcga aggcggctgc 4500 aacgtccagc tggcgcttga cccggacagc ttccgctatt acgtcattga agtgaacccg 4560 cgcgtcagcc gctcgtcggc gttggcgtcc aaagcaacgg ggtatccgat cgcgaaactg 4620 gcggcgaaaa tcgccgtcgg gttgacgctt gatgaaatga tcaacccggt taccgggaaa 4680 acgtacgcct gcttcgagcc ggcgctcgac tatgtggtga cgaaaattcc gcgctttccg 4740 tttgacaaat ttgaatcggc gaaccgccgc cttggcacgc aaatgaaagc gaccggcgaa 4800 gtgatggcga tcggccggac gttcgaagaa tcactgttaa aagccgttcg ttcgctcgag 4860 atcggggtgc atcatctgga attgaacgag gcgaaaacgg ccgccgacga cgtgatggaa 4920 aaacggatcc gcaaggcggg cgatgaacgg ctcttttaca tcgccgaggc gctccgccgc 4980 ggggtgacgg tggagacgct gcatgaatgg agccaaatcg accgcttttt cctgcataag 5040 attcaaaaca ttattgagat ggaaacggtc ttgaaaaacc acccgggcga ccttgacgtg 5100 ttaaaaaaag cgaaggggct cggcttctcc gatgcggcga tagcggcgtt atggaacaaa 5160 acggagcgcg acatttacgc cgtgcgccgc caacgaggca tcatgccggt gtacaaaatg 5220 gtcgatacgt gcgcagccga attcacgtcg gaaacgccgt actactacag cacgtacgag 5280 gaagaaaacg aatcgatcgt gacggaaaaa ccgagcgtca tcgtgcttgg ctccggcccg 5340 atccgcatcg gccaagggat cgaatttgac tatgcgaccg tccattgcgt ctgggccatt 5400 aagcaggccg gctatgaggc gatcatcatc aacaacaacc cggaaacggt ctcgaccgac 5460 ttcagcacgt cggacaaact gtatttcgag ccgctgacgg ccgaagacgt gatgcatgtc 5520 atcgacctcg agcagccgat cggcgtcatc gtccaattcg gcggtcagac ggccatcaac 5580 ttggcggcgg aactcgaggc gcgcggcgtc cgcttgcttg ggacaacgct tgaggatttg 5640 gaccgcgccg aagaccgcga caaatttgaa caggcgctct cggaactcgg cattcccaaa 5700 ccggccggca aaaccgccgt ttcggtcgaa gaagcggtcg ccatcgctga agaaatcggc 5760 tacccggtgc tcgtccgtcc ttcgtacgtg ctcggcggcc gggcgatgga aatcgtgtac 5820 aatcgcggcg agctgcttca ttacatggaa cacgccgtgc gcgtcaatcc acagcaccca 5880 gtgcttgtcg accgctacat cactggcaag gaagtcgaag tcgatgccat cgccgacggc 5940 gagacggtcg tcatccccgg gatcatggaa catatcgagc gggccggcgt ccattccggc 6000 gattcgattg ccgtctaccc gccccagaca ttaagcgcgg aagtgatcga caagatcgcg 6060 gattacacga tccgactggc gcgcgggctg catattgtcg ggctgttgaa cattcagttt 6120 gtcgtctcgg gaagcgatgt ctacgtcttg gaagtgaacc cgcgctcaag ccgcacggtg 6180 ccgtttttaa gcaaaatcac cggcgtgccg atggcgaatc tcgccacgaa agccatttta 6240 gggacgaagc tcgccgagat gggctatgag acgggcgtct gcccggtgcg ccctggcgtg 6300 tacgtgaaag tgccggtgtt ctcgtttgcg aaattgcgca acgtcgacat ttcgctcggc 6360 ccggaaatga aatcgaccgg cgaagtgatc ggcaaggacg tgacgtttga aaaagcgctc 6420 tataaggggc ttgtcgcctc gggcatccat atccagccgc atggggcggt gctgttgacg 6480 gtggccgaca aagacaaaga agaagcggtc gagctggcgc gccgctttgc cgacatcggc 6540 taccagctgt tggcgacgaa cggcacggcg gaaacgttga aagcggccgg cattccggtg 6600 acggtcgtca ataaaatcca ctcggcgtca ccgaacattt tggatgtcat ccgccaaggg 6660 aaggcgcaag tcgtcatcaa cacgctgacg aaaggaaagc agccggaaag cgacggcttc 6720 cgcatccgcc gcgaagcggt cgaaaacggc atcccgtgct tgacgtcgct cgatacggcc 6780 cgggcgatgc tgcaagtgct cgaatcgatg acgttttcaa cgacggcgat gacggaaggg 6840 ctggtgcggt catgatcggc cgcgaacgaa tgacggtcgc aagccagcgg ttgatcgccg 6900 agcggacgta tgaattgacg ctttcaggcc gcctcgtgca agagatgcgc caaccgggcc 6960 agttcgttca tgtgaaagtg gccgcatccg ccgatccgct cctgcgccgc ccgctcagcc 7020 tttgccatat cgaccacaag caggggcaat gcacgatcat ttaccgccag gaagggaaag 7080 gcacggcgct gttggcgcaa aaacagccgg gcgacacggt cgatgtgctc ggcccgctcg 7140 gcaacggctt tccgctcgag gccgcgccgg cgggcagccg ggcgctgcta gtcggcggcg 7200 gcatcggcgt cccgccgctc tatgaactgg cgaaacagct cacaaagcgc ggcgtcaaag 7260 tggtgagcgt gctcgggttt caaacgaaag cggcggtctt ttacgaagag gaatttgccg 7320 cgttcggcga gacgcatgtc gcgaccgatg acggctcgca cggaacggcc gggcgcgtca 7380 ccgatgtgat cgaagcgcgc tcgctcgagt ttgacgtctt gtacgcctgc ggtccgaagc 7440 cgatgcttcg ggcgcttgcg gaacggtttc cgaaccggcc ggtgtacttg tcgctcgagg 7500 agcggatggg ctgcggcgtc ggggcgtgtt tcgcctgcgt ctgccatgtg ccagggagcg 7560 agacggcgta taaaaaagta tgcagcgacg gcccggtgtt tcgggccggg gaggtggtgc 7620 tatgaaccgg cttgcggtcg aactgccggg tctttcgctc aaaaacccga tcatgccggc 7680 gtccggctgt tttggatttg gccgcgagta cgcccggttt tacgatttaa gcgtgttagg 7740 cgccattatg atcaaggcga cgacaaaaga gccgcgcttt ggcaacccga caccaagggt 7800 ggcagaaacg ccgggcggga tgttaaacgc catcggcctg caaaaccccg gccttgacaa 7860 agtgctcgaa gaagaactgc cgtggcttga acagtttgac gtaccgatca tcgccaacat 7920 cgctggctcg acggtggaag agtacgtcga ggtagccgaa gcgatttcca aagcgcccaa 7980 tgtccatgcg ttagagctca acatttcctg cccaaacgtg aaaaaaggcg ggattgcgtt 8040 cggcaccgtg ccggacgtgg ccgcggaact gacgcggctt gtcaaagaag tggcggctgt 8100 ccccgtgtat gtgaacgtgt cgcctaacgt tacggacatc gtcgcgatgg cgaaagccat 8160 tgaacaagcg ggtgctgacg gcctgacgat gatcaacacg ctcgttggca tgcgcatcga 8220 cgtgaaaaca ggccggccga ttttggccaa cggcaccggg ggcttatccg gcccggcggt 8280 gaaaccgatc gccatccgca tgatttatga agtgagccag gcggtgtcga ttccgatcat 8340 cggcatgggc ggcattcaaa cggcggaaga cgtgctcgag tttttctacg ccggcgcgag 8400 cgcggttgcg gtcggcacgg ccaacttcgt cgatccgttc gtctgcccga cgatcatcgc 8460 cgacctgccg gcgctgttgg acgacctcgg gatcggccac atttccgaat gcataggaag 8520 gagctggaag accggtgcac acgccgttca ttgtcgcgct tgatttccca tcaaaacaag 8580 aggtggagcg gtttttgcgg ccgtttgccg gaacgccgct gttcgtcaaa gtcggcatgg 8640 agctgtacta tcaggaaggt ccagccatcg tcgcgtttct caaagaacaa ggacatgccg 8700 tctttttaga cttaaaactg catgacatcc caaatacggt gaaacaggcg atgaaagggc 8760 tcgcccgtgt cggcgccgat ttggtgaacg tccacgccgc cggcggccgg cgcatgatgg 8820 aagcggcgat cgaggggctt gacgccggca cgccaagcgg aagaatgcgg ccgcgctgca 8880 tcgctgtcac ccagctgaca agcacggacg agcgaatgct tcatgaggag ctgtggattt 8940 cccgcccgct tgcggaaaca gtcgcccatt acgccgcctt ggcgaaagag agcggccttg 9000 acggcgtcgt ctgttcagcg aacgaagcgg cgttcatcaa agaacggtgc ggcgcctcgt 9060 tccttgccgt caccccgggt atccgctttg ctgatgatgc ggcgcacgac caagtgcgcg 9120 tcgtcacccc aaggaaagcg cgtgcgcttg gttctgacta catcgtcgtc ggccgcagcc 9180 tcacccgcgc cgccgatccg ctcggggcgt atgcccgcct gcaacacgaa tggaacggag 9240 gagagagaga gtcaactacc cccacttagc taacgcttga agtgggggct tgcaactccc 9300 cagaagtgca aacgacttcg tcctccttcc ttgacttggg gttgcatcag ggggcaggtt 9360 gacgactacc caacgacgca ggtcatgcct gcatcgttac cgattctctc ggtgtgtctg 9420 ttggcagtac ttggcttcca cacacaacag acagacctac gctcgatgtt ttacggttac 9480 aacgtttcct gtaaccaact ccatacatcg agtagccgtg attggagtgc ctttattgaa 9540 cggttttctc cacgccttta ttatatcata cacaaaagaa aggggggaac gcgcattcct 9600 ctcccactta ctccctttgg tcgttgaagt gggagtctcc tgcgcgaaat aggatgaaac 9660 acgacatcgc cgccaaactg cttcaaatcg gggcggtcgc cctgcagccg aatgaaccgt 9720 ttacctggtc ctcgggcttg aaatcgccga tttattgcga caaccgcctg acgctcgctt 9780 accccggcgt gcgccgcctg atcgccgacg cgctcgccga actcatccgc acccatttcc 9840 ctaaagcgga cctcatcgcc ggcacagccg ccggcatccc gcacgccgcc tgggtgagcg 9900 agcggcttga gctgccgatg tgctacgtcc gcagccaggc gaaacgacac ggcaaaggaa 9960 aacaaatcga aggccaagcc agaccgggcc agcgcgtcgt cgtcatcgaa gacttgatct 10020 cgacgggcgg cacgtcgctt gcggccgtcc gcgccttgaa agaggcaggc tgcgaggtgc 10080 tgggcgtcgc cgccattttc acatacgggc tcgaaaaagc gaaacaggcg tttgccgcag 10140 agaatttgcc tgcctacacg cttacggact acaacaccct catcgaaacg gccgtccgcc 10200 ttggcgccgt cagcgaacac gatctggcga cattgcggca atggcgggag aatccggagg 10260 agtgggggag ctaaaagagg aaaagaggag cgcggaccaa aggatggttc gcagcttttg 10320 tcatggacga agcggggaga tgactcactg ccatcggcgt cattccatgg ggaaaaacgg 10380 agtgcgacag cgtctaatgt cgtcaatatt tcgtgggttt tctgaacatg agcaagtttc 10440 gctcaccacc aagcatgaac ataaccattc gtggtaggtt atgttcacag aaaacggtgc 10500 tgcatcaata aatgatcatt tacagcattt cgcttagtgg tcacgatcat catcacaagc 10560 aaccattcgc attctccatt tcacctcaat attttactca cacctgcgga tttccctgct 10620 ggcaatcaag attggaaccg tgccgccgtt tcgattcaac cttccaagcc aattgataaa 10680 atcgacatat ccgctgtctt ccgcggcaat tacacgggaa cggtatggtt tgacgcgatc 10740 cggctcatgg aaggaaacgt ggtgacgaaa aacaaatacg atgccagcgg aaatgatgtc 10800 acggaagaag tggatgaaga aggctatgtg gcgaaaaaga attatgatgc cgtagaaact 10860 tgttaagcga gtacgataag aaaggaaaca agaaagagta cacgtatgat tgaagaagga 10920 tgactctaga gt 10932 // |
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