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EBI DbfetchID X68366; SV 1; circular; genomic DNA; STD; PRO; 13514 BP. XX AC X68366; XX DT 09-OCT-1992 (Rel. 33, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 7) XX DE M.thermoformicicum complete plasmid pFV1 DNA XX KW DNA metabolism; DNA methyltransferase; restriction endonuclease; KW restriction-modification system; TIM gene; TIR gene. XX OS Methanothermobacter thermautotrophicus OC Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; OC Methanobacteriaceae; Methanothermobacter. OG Plasmid XX RN [1] RP 1-13514 RA Noelling J.; RT ; RL Submitted (24-SEP-1992) to the EMBL/GenBank/DDBJ databases. RL J. Noelling, Agriculture Univ of Wageningen, Bacterial Genetics Group, RL Dept. of Microbiology, Hesselink van Suchtelenweg 4, 6703 CT Wageningen, RL THE NETHERLANDS XX RN [2] RP 1-13514 RX DOI; 10.1093/nar/20.24.6501 RX PUBMED; 1336177. RA Noelling J., van Eeden F.J.M., Eggen R.I.L., de Vos W.M.; RT "Modular organization of related Archaeal plasmids encoding different RT restriction-modification systems in Methanobacterium thermoformicicum."; RL Nucleic Acids Res. 20(24):6501-6507(1992). XX FH Key Location/Qualifiers FH FT source 1..13514 FT /organism="Methanothermobacter thermautotrophicus" FT /plasmid FT /strain="THF" FT /mol_type="genomic DNA" FT /db_xref="taxon:145262" FT CDS complement(join(13251..13514,1..822)) FT /transl_table=11 FT /note="ORF8" FT /db_xref="UniProtKB/Swiss-Prot:P29584" FT /protein_id="CAA48425.1" FT /translation="MPVNPPPTTPTDNLNFNKTVEFKFPQELGKPPLRKGVAPKLLLGH FT LVVLPIYLSGGTPMGGHDGIQEDLLIVPQLLDTTPDKLNLNLISRHPDVRLTYNTLKLP FT YRNIRRKAEEVKGIPGVPVTLGRERRTQWHNVVFQDTVVKRHLNPVVQDLLKLRGAVRG FT ETDSPWLKRGYDPRVADHIHYGQLVGKTHNAHIRLPRKVVEEFIPVPGKSLIDLVHDNY FT HLALRGPFPNLLHNVQEPKTASGGPGNGRCDLVGSAVRNDILNYRVTGVLLEFVDHILR FT RDSLPRSWGPYNQQVGWGGAVEDVPQVLADSTHLFLSVLQGVRHKERAEDIPVFEKSRS FT LLKHLQLPAIQLYNSKPHFYM" FT exon 1..885 FT /number=2 FT /note="ORF1" FT exon complement(1..822) FT /number=1 FT /note="ORF8" FT CDS 1511..2365 FT /transl_table=11 FT /note="ORF2" FT /db_xref="UniProtKB/Swiss-Prot:P29571" FT /protein_id="CAA48426.1" FT /translation="MNSGNLFFGWADESSQNKGRYRAIGMVSHPAEFESKLEGDINNIL FT DYVFDESGLKRRELKWNKIDIFRCRAYERIVDYFLEHTGLGNPPFRVDILRWDIEDSRH FT SIQGRDDNQNLQRMYYHLFSNVISKRWPSGDWCFFPDKTGSVDWGELASFLDLGGSKVD FT LNERFNIRSINEVDSKDNVLVQVADFFAGLSVFSKEKLGLYVDWKFEKRGQQRLVPVEK FT IDLSKKDRRRFKILSYFEEGCEKLKIGVVLDRSKGLWTPNPANSINFWHYEPQSDADKA FT PTR" FT CDS 4439..5032 FT /transl_table=11 FT /note="ORF3" FT /db_xref="UniProtKB/Swiss-Prot:P29573" FT /protein_id="CAA48427.1" FT /translation="MNLRQKVIETLEEGKSVAIKYQDVRDYLDLKTGHRVIFLEHVNPA FT KETAAEILADLGNLAKSTIYSKYTTNEIVRDIKKRSKNRNVLLVFNDFQLLSKNTARVL FT LDLMEDVQVLCSIRGRPQKGQGRLLKRMTILSDRSDEVTDIKIPLIVFASFIAILTFVK FT AGSTIYNRNHFDFYLFSAAIFVGISVGRTLLWIS" FT CDS 5153..5866 FT /transl_table=11 FT /note="ORF4" FT /db_xref="InterPro:IPR007404" FT /db_xref="UniProtKB/Swiss-Prot:P29575" FT /protein_id="CAA48428.1" FT /translation="MVYSRPIFCLCGDILWLSLERRAFTILFYVDNSFVCSSGLCRKGG FT VNEHKRQLHNVFTLIPFVLLYFFYDVTTGAAMLSGVSSHILLDFMTPTGCPFFYPIYRG FT RYRVNWRHKGSGPREKRALTTIGILAAILLLVIYAPSPFAPTSAISQWKGSGSGVNNTS FT NNGTDINVNFNFRGNGDTWIHPYPNGSIFIDCVGDSNSRVYRYRASSRGGQGKYLKLDS FT NTTENKTTKQNETGG" FT CDS 6230..6913 FT /transl_table=11 FT /note="ORF5a" FT /db_xref="GOA:P29577" FT /db_xref="InterPro:IPR001434" FT /db_xref="UniProtKB/Swiss-Prot:P29577" FT /protein_id="CAA48429.1" FT /translation="MRNGTLVLAALLTLFVLAGSSSAADVGIELDKNMSDGSPIKPTYN FT STIKIKAIVKAWNLDVQNATARVQLPEGLVVQDYYMSQGYYDLETGTWEIGDIPAYEER FT SLTFICLLNRTGSVTVNANVTADGDDNSANNNAELTFKVFGISDLEVNVTGNKETARIG FT DTVRITVKLKNRGPHDANNIKIGNFLSGGLVVQNFSYDAGYFDDITREWIFETLAAGEE FT AKSKP" FT CDS 6913..8268 FT /transl_table=11 FT /note="ORF5b" FT /db_xref="GOA:P29578" FT /db_xref="InterPro:IPR001434" FT /db_xref="UniProtKB/Swiss-Prot:P29578" FT /protein_id="CAA48430.1" FT /translation="MKAWNLDVQNATARVQLPEGLVVQDYYMSQGYYDLETGTWEIGDI FT PAYEERSLTFICLLNRTGSVTVNANVTADGDDNSANNNAELTFKVFGISDLEVNVTGNK FT ETARIGDTVRITVKLKNRGPHDANNIKIGNFLSGGLVVQNFSYDAGYFDDITREWIFET FT LAAGEEATLTLDCLVNRTGELSDYVSVREVDEGDVNVYNNMAHASVAVKGTDLDLDLSV FT SKLRAYQGDVVNVVCRVRNNGPETAQNARVNLQLPGNLQVQHVQLDRGTYSNGVWVIGD FT LADNETALLNITARVMSAGNFTLNATAVSPAIDDSNPVNNDDTARISVAIPKKTLKVRI FT KNNSAVTIRVLLYVTVNDHGKITRKTYNFYLKKGLSRDLSLGYFQLGTTALFKQYTYNT FT NYRSRTVSYENTYNATSVITQRVNVSGVKGRQKAPVVRIATLLLDENGTSLQ" FT CDS 8355..8723 FT /transl_table=11 FT /note="ORF6" FT /db_xref="InterPro:IPR002732" FT /db_xref="UniProtKB/Swiss-Prot:P29580" FT /protein_id="CAA48431.1" FT /translation="MRQIAEMRKEVSQHGFDVRMMEVPGMKVAIAGDGEVNYLFMLLPF FT RDKFKLKKRDVWLFKKLSYKFKARPFLVTFDKMLSFYPLHALEEGGEHFELDIRNSRGL FT MFSFDTIVSEQLQQRLVV" FT CDS 9187..9624 FT /transl_table=11 FT /note="ORF7" FT /db_xref="UniProtKB/Swiss-Prot:P29582" FT /protein_id="CAA48432.1" FT /translation="MEHIESKVKCYRRKYKRKGKEYTTTQYVINLRKEGVESQGFKCDE FT DVIITHKSTFESLIDMKKDHEANLKEKESLQKNLSELQVEFNKLKNEYKHVKALLDKKE FT REVNHLENEVRRLQNMGLFEIILNKLRKKKAIEGEVEEGVK" FT CDS complement(9636..10301) FT /transl_table=11 FT /note="ORF10" FT /db_xref="GOA:P29588" FT /db_xref="InterPro:IPR000445" FT /db_xref="PDB:1KEA" FT /db_xref="UniProtKB/Swiss-Prot:P29588" FT /protein_id="CAA48433.1" FT /translation="MDDATNKKRKVFVSTILTFWNTDRRDFPWRHTRDPYVILITEILL FT RRTTAGHVKKIYDKFFVKYKCFEDILKTPKSEIAKDIKEIGLSNQRAEQLKELARVVIN FT DYGGRVPRNRKAILDLPGVGKYTCAAVMCLAFGKKAAMVDANFVRVINRYFGGSYENLN FT YNHKALWELAETLVPGGKCRDFNLGLMDFSAIICAPRKPKCEKCGMSKLCSYYEKCST" FT CDS complement(10294..10734) FT /transl_table=11 FT /note="ORF9" FT /db_xref="UniProtKB/Swiss-Prot:P29586" FT /protein_id="CAA48434.1" FT /translation="MVVKIRRAGNICRLFEEDLSQYRGEYEDCVDYLPEILFLLAELLR FT SESLEEVDRLKVAAALGYSVSPLDMFPEEIYGPYSFLGDLFVSLTVLRDVVDAIGLNTV FT ENLWRGEVRLFDLLEDCYNRVSKELGAKKKLFLKHVGLDLIG" FT CDS 10828..11673 FT /transl_table=11 FT /gene="TIR" FT /db_xref="GOA:P29565" FT /db_xref="InterPro:IPR019046" FT /db_xref="UniProtKB/Swiss-Prot:P29565" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA48435.1" FT /translation="MSNLLQAIMNIKSIQERNLGSYKGVQDSKNRMNQMGVTLEVFLKD FT AFCNTFDIENKDLVYSEYFSYLGNQNNPPDMILKGGDAVEVKKITGIKTSIQLNSSYPK FT SKLFVSDSRITEACKNCEDWEVKDIIYAIGTIPNRVLKLMFFVYGDCYAASPSIYQRIV FT EEVKGGLHSTGLEFSETNELGRINRVDPLGITDLRVRGMWIIKHPIKVFKNIIPPESIK FT NNNFNLIALMKAEKYKQFPKKDRKRIEAEDNIEVTDVKIKDPDNPAKLLDSVLVRYDEI FT " FT CDS 11670..12662 FT /transl_table=11 FT /gene="TIM" FT /db_xref="GOA:P29567" FT /db_xref="HSSP:1DCT" FT /db_xref="InterPro:IPR018117" FT /db_xref="UniProtKB/Swiss-Prot:P29567" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="CAA48436.1" FT /translation="MNMDIASFFSGAGGLDLGFTKAGFNIVFANDNWKGCWKTFEKNHG FT IKINKKPIEWLKPSEIPDVVGFIGGPPCQSWSLAGSMCGADDPRGKTFYAYVDLVKEKD FT PLFFLAENVPGIVSRTHLPEFKRLVNSFIDIGYNVEYKVLNAKDYGVPQDRKRVFIVGY FT REDLNLKFEFPKPLNKKVTLRDAIGDLPEPKPALEKNRSNGENLEVPNHEYMTGTFSSR FT YMSRNRVRSWDEVSFTIQAGGRHAPCHPQANKMIKVGPDKFIFDPESPKPYRRLSVREC FT ARIQGFPDDFIFYYKNVADGYTMVGNAVPVKLAEELAKKIKKDLEGVLN" FT CDS join(13305..13514,1..885) FT /transl_table=11 FT /note="orf1" FT /db_xref="GOA:P29569" FT /db_xref="InterPro:IPR014277" FT /db_xref="UniProtKB/Swiss-Prot:P29569" FT /protein_id="CAA48437.1" FT /translation="MFEKRPRLFKNRDVLSPLFVPDTLQDRKEEVGAISQYLGYILDGA FT TPPHLLIVGPPGSGKTVTTKYVINELEKHTSDAVIEYIVADGTAYQVATSIARAPRRGL FT GFLNIVEKIRERASEGKMIIVMDEIDKTLSRDGDKLLYHLSREPNVCIVGLSNKLTVMD FT MIGDSGVISSFKPRRISFAPYSAPQLEEILNYRVEMAFNDGVLEDDVVPLCAALAAQRN FT GDARYALDLLSFAADIAIRQLKGVVSESDVRMATDEVEVEFIRRSIEQLRDNQKILLYA FT VMTSHGGTPTEIYRKYNKMTEEQFGGNALTQRRLSQLLRELELYGLVEIEVVGRGRGRG FT VNWHVVPSSSIDPELMLEAIRRSL" FT exon 13305..13514 FT /number=1 FT /note="ORF11" FT exon complement(13251..13514) FT /number=2 FT /note="ORF8" XX SQ Sequence 13514 BP; 4056 A; 2682 C; 2963 G; 3813 T; 0 other; ctcgagaagc acaccagtga cgcggtaatt gagtatatcg ttgcggacgg cactgcctac 60 caggtcgcaa cgtccattgc cagggccccc cgacgcggtc ttgggttcct gaacattgtg 120 gagaagatta gggaaagggc ctcggagggc aagatgataa ttgtcatgga cgagatcgat 180 aagactcttt ccagggacgg ggataaactc ctctaccacc tttctaggga gccgaatgtg 240 tgcattgtgg gtctttccaa caagttgacc gtaatggata tgatcggcga ctcgggggtc 300 atatcctcgt ttaagccaag gagaatcagt ttcgcccctt acagcgcccc gcagcttgag 360 gagatcctga actacagggt tgagatggcg tttaacgacg gtgtcctgga agacgacgtt 420 gtgccactgt gtgcggcgct cgcggcccag cgtaacgggg acgccaggta tgcccttgac 480 ctcctcagct ttgcggcgga tattgcgata aggcagctta agggtgttgt aagtgagtct 540 gacgtcagga tggcgactga tgaggttgag gttgagttta tcaggcgtag tatcgagcag 600 ttgagggaca atcagaagat cctcctgtat gccgtcatga cctcccatgg gggtaccccc 660 actgagatat ataggaagta caacaagatg accgaggagc agtttggggg caacgccctt 720 acgcagagga ggctttccca gctcctgagg gaacttgaac tctacggtct tgttgaaatt 780 gaggttgtcg gtaggggtcg tgggaggggg gttaactggc atgttgttcc ttcgtcctct 840 attgaccctg aactcatgct tgaggccata aggaggtccc tctgagacta cttgggggca 900 actttctctg ggtttaagtt gattgacctt atacttgatg ggtactttaa cttacccttt 960 tactattaac ttttctttaa tgggggtatc tagggcttgt cctgtaatct tcctgagtgc 1020 agcattgtct tttcagaaca atttttcgtt caataaaatt gttgggtctt tggttgacct 1080 ctagtttggt aatgtcctat gggtcggcta agcgatttcc gccctttcgg gtcgctcgct 1140 tcgctcgctc ggaaatcgcc gccgaccagg ggggctacca ccccccaccc cccgccccac 1200 tttaggtaac ccatacctca acttgtgatt ttgtgaattt accccttcac tccgccccga 1260 cactcttata tagacgccag cttcgtcagt acctcgtatt atacgaagta acgctcgctt 1320 cgctcgctct cgcttcgctc gtacttcgta taatactaag aggtatgacg aagctggcgt 1380 gaattatttt tgagtgtctg ggctccgtga aggggtgaac gaacaccaca taagtggagt 1440 tcattgtaat taagttgtaa ctaaccttta taaggataat ataagatagg tgtctattag 1500 ggttgttaaa atgaattcag gtaatctttt ttttgggtgg gcagatgaat ccagccagaa 1560 caaggggaga tatcgggcta ttggaatggt aagccacccg gccgagtttg aaagtaaact 1620 tgaaggagat ataaataaca tacttgacta tgtatttgat gaatctggtt taaaaagaag 1680 agagttaaaa tggaataaaa tagacatatt ccggtgtagg gcatatgaga ggattgtaga 1740 ctacttttta gagcacactg gtcttggcaa tccaccattt cgtgtggata tcttacggtg 1800 ggacattgaa gacagccgtc atagtataca agggcgggat gataaccaaa acttgcagag 1860 gatgtactat catctctttt caaatgtgat ttctaagcgt tggccttctg gagattggtg 1920 cttttttcct gacaaaacgg gttcagtcga ttggggggaa ttggcgtcct ttttggatct 1980 tggcggttca aaagtagacc taaatgaacg gtttaatata cgaagtatta atgaagttga 2040 ttccaaggat aatgtactag ttcaggtggc tgattttttc gcgggactca gtgttttttc 2100 taaggagaag cttgggcttt atgtagactg gaagtttgaa aaacgtggac agcaaagact 2160 agttcctgta gaaaaaattg acctctccaa aaaggatagg aggcgtttta aaattctttc 2220 ttatttcgaa gaggggtgtg aaaagttaaa gatcggggta gttcttgata gaagtaaagg 2280 cttgtggaca cctaatcctg ctaacagtat aaatttttgg cattatgaac ctcagagtga 2340 tgccgacaaa gcacctacaa ggtaacctca aatagttgtt ttaacttgtt ctttggggtg 2400 agggattcac cctcccccca aaccccccac ccgaaggtcc cggcgctcgc tccgctcgct 2460 tgggtcaccg caccaatctt ccgttactcg ctccagcggc tgtgcggaaa ttctcgccct 2520 ccgggtcgtt cgcttcgctc actctcgaat ttcctaaaac agccgctttc gctgcgttac 2580 tcagattggg cgggaaaaac cagtgaatga gatcggcggg cgttctcgtg ggaggacccg 2640 tctaccatgt tccaaaaaat aaaatcaata tatattgacg gctgcaacca ttacaaccaa 2700 aacctgccga cccaaatcct atttttcaat gttttacagt atattttgcc tgctttttct 2760 aatataaagg tttaatgacc tgtttaatgc atttttcagg tttttagaat gtgaaattat 2820 ggtggctgtc ttcggttgta accaccctag gaaatttctc tttacaggtt tcccgcatct 2880 tacagggatt aaccatattt tgttctaaat cattttcaat atcatcagaa atataaacag 2940 atactgaatt caaaatatcc ttttttaagt tgcttagcat taaatcaagg tattcttgat 3000 tagatttttc catcaaacgc ttgatatcct gatgtatagc ttctaatttc attcgggcat 3060 catagaattc aggattatcc attttattta gattttccat aaattatttt attgatttag 3120 atagtattaa aggtttcttt cttgaccttt taagtcatat ttgtgtataa aactgtactt 3180 agtacatttt aatgacggtt tagtatatat ttctaataaa caatagttat atttgaaatt 3240 aaaaacttaa tggagatgtg aaaatgggag ttaaagaaga tattcgtgga caaattatag 3300 gagcattagc aggagccgat ttcccaataa attcaccaga agaactaatg gcagcgcttc 3360 caaacggtcc agatactact tgtaaatctg gagatgtaga attaaaagca tctgatgctg 3420 gacaagtact tactgctgat gattttccat ttaaaagtgc tgaagaagtt gcagatacta 3480 tagtgaacaa agcaggatta taagccaaaa tcgacttcct actttttctt tcttttcttt 3540 tttaaggata attaattatt atcttataat aggttttaat ggagaaatta aaatggataa 3600 gcccaatagt aaagaaaata agcataagtc ccgttgtact gaatgtccgt catataatga 3660 atgtatgtgc gtttggttag attattttgc tggaaaaata gaataatttg cagtaatatt 3720 aagtcctact gctttcacta cagattaaat attaaacaat caataatttt caattgattt 3780 taagaatgcc ccccctccag ttttcaatag ttcaaccgga ggggataata gttctgaaac 3840 gattattttt tcaaatattt tttaaaatta ctgagcatta tgagtagatt atatcctttt 3900 tcagtaatca tataatctcc acgttcatga cgctgcaata tcaagtcact ttcaagtaat 3960 ttttgtatgt ggaaaagtaa attaccacca cgaagccctg taagttctga aagagcagtg 4020 aatgtcatgg tttcagaggc catagattta aagaatttga agtctctgtt tattagaaat 4080 aggttcaaga acactcttaa ccataatttc ttcaggaata gaagatatct cagttttatc 4140 ctctttatta ttgtcatata tttgtagaga gccaattaga tttatttgct tatcaaatag 4200 tgagtctact tccttaaaac aaatatcaca tttatcaaaa ggagcacttt tccttatttc 4260 atctaattcc tctcttttct cttctataat ttctttggaa acatgttcct gttttataag 4320 tttagaatta ttttgtagaa atccgttaaa ttttaatatg aaaaaattaa ataatattat 4380 tataatatta ataattaata ttaataattt aataatgcgc aggtagtttt tacgggtgat 4440 gaacttgagg cagaaagtta ttgaaaccct agaagaaggg aaaagtgttg cgattaagta 4500 ccaggatgta agggattacc tcgacctgaa aacgggtcat agggttatat tccttgaaca 4560 cgttaaccct gcaaaggaga cagctgctga aatattggct gaccttggca accttgcaaa 4620 aagcactata tacagcaagt acacaacgaa tgagattgtc agggacatca agaagaggtc 4680 gaagaacaga aatgtcctcc tagtgttcaa tgactttcag ttgctttcta agaacactgc 4740 aagggttctt ttggatctca tggaagatgt ccaagttctt tgtagtatcc ggggcagacc 4800 ccagaagggt caggggcgtt tgcttaagag aatgaccatc ctaagcgata ggtctgacga 4860 ggtcactgat attaagatac ccctcatagt ctttgcgagc tttatagcaa tattaacctt 4920 tgttaaggcg ggctcgacca tctataacag gaaccacttc gacttttacc tgttttctgc 4980 ggcaattttt gttggcatat ctgtggggag gactctttta tggatttctt aagttcaggc 5040 aggtacctcc tgtttatatt ctgggtcctt atgggcttcg gcgcggctta ttacattttc 5100 tggctttacg ccgtaggtta tcaataggtc ggggggtcgt ggtaattttg aaatggtata 5160 ctcacgccct attttctgtc tttgtggcga tattctttgg ttatctcttg aacgcagagc 5220 tttcaccata cttttttatg ttgacaattc tttcgtctgt agtagtggac tttgcagaaa 5280 aggcggcgtt aacgagcaca aaaggcaact tcacaatgtt ttcaccttga taccctttgt 5340 tctcttgtac tttttttatg atgtgaccac aggcgccgcc atgttgtcgg gcgtatcttc 5400 ccatattttg cttgatttta tgacgccaac gggctgcccc tttttttacc cgatttacag 5460 ggggcgttat agggtcaatt ggaggcataa gggtagcggt cccagggaaa aaagggcgtt 5520 aacaactata ggtattcttg cagcgattct actacttgtc atctatgcgc cgtccccatt 5580 tgcgccgact tcggcaattt cccagtggaa gggttctggc agcggggtca ataacacgtc 5640 aaacaacggg acggacataa atgtgaattt taacttcaga ggcaacggtg acacctggat 5700 tcacccttac cctaatggca gtatcttcat tgactgtgtg ggtgacagta acagcagggt 5760 ttacaggtat agggctagca gcaggggagg tcaaggtaag tacctgaaat tggattctaa 5820 caccaccgaa aacaaaacca cgaagcaaaa tgagacgggg ggatgactct ggcaaggcgg 5880 agccctgctt ttgagaaggt ctgcagtttt atagagaagt ctgagaggtt ctgtactgac 5940 aagaaaatct atactcagaa ggtttacctg gacactagga ccgcctgtaa gcttgagatt 6000 atcagctata tcgagtcaaa atcaaaaagt gaactttcga gggaggctat taagttattt 6060 atagacatat atgaatctaa aaatggcaac ataataaata aggtgattga aaccaggatt 6120 gaatgattat taacctttat tttttaattt taacttcttg ggcccaaaat tatgtattat 6180 aatttaacaa tattgtatta ctagaaattc tccgggaggt gaaaaaagca tgcgtaatgg 6240 aacattagtg cttgcagcgc tcctgacact ctttgtcctt gcaggttcat catccgcggc 6300 ggatgtcggc attgaacttg acaagaacat gagtgatggg agcccgataa agccgaccta 6360 caattcgacg attaaaatca aagccatagt gaaggcctgg aacctggacg ttcagaatgc 6420 cactgcaagg gttcaacttc ctgagggcct cgtggtgcag gactactaca tgagccaggg 6480 atactatgac ctcgaaacag gtacctggga gattggtgat atcccagcat atgaggagag 6540 gtccctgaca ttcatttgcc tgctgaacag gactggcagc gttactgtga acgccaatgt 6600 gacagcggac ggagatgata acagtgcaaa caacaatgca gagttaacct tcaaggtatt 6660 cggtatatca gaccttgagg ttaacgtcac aggcaataaa gagactgcaa gaatcggcga 6720 cacagtgagg ataactgtta aacttaaaaa caggggcccc catgatgcga ataatatcaa 6780 aataggcaac ttcctctcag ggggtcttgt tgtgcagaat ttcagctatg atgcgggcta 6840 ctttgatgac atcaccaggg agtggatctt tgaaaccctt gcagcaggtg aggaggccaa 6900 atcaaagcca tagtgaaggc ctggaacctg gacgttcaga atgccactgc aagggttcaa 6960 cttcctgagg gcctcgtggt gcaggactac tacatgagcc agggatacta tgacctcgaa 7020 acaggtacct gggagattgg tgatatccca gcatatgagg agaggtccct gacattcatt 7080 tgcctgctga acaggactgg cagcgttact gtgaacgcca atgtgacagc ggacggagat 7140 gataacagtg caaacaacaa tgcagagtta accttcaagg tattcggtat atcagacctt 7200 gaggttaacg tcacaggcaa taaagagact gcaagaatcg gcgacacagt gaggataact 7260 gttaaactta aaaacagggg cccccatgat gcgaataata tcaaaatagg caacttcctc 7320 tcagggggtc ttgttgtgca gaatttcagc tatgatgcgg gctactttga tgacatcacc 7380 agggagtgga tctttgaaac ccttgcagca ggtgaggagg ccaccctcac acttgattgc 7440 ctggttaaca ggacgggtga gctctcagac tatgtttcag tgcgtgaggt cgatgagggc 7500 gatgtgaatg tctacaataa catggcccat gcatcagttg ctgttaaggg aactgaccta 7560 gaccttgacc tctctgtgag taaactgagg gcatatcagg gtgacgtggt caatgtggtc 7620 tgccgtgtca ggaacaatgg tcctgagacc gcccagaatg ccagggtcaa cctccagcta 7680 ccgggtaacc tgcaggtcca gcatgtgcag ctggacaggg gcacctacag taacggtgtc 7740 tgggtcatcg gtgaccttgc agacaatgaa acagcactcc tcaatataac cgcaagggtg 7800 atgtcagcgg gtaacttcac actgaacgcc actgcggttt cacctgcaat cgacgacagc 7860 aaccccgtga acaacgacga tacagcgcgg atatctgtag caataccaaa aaagaccctc 7920 aaggtgagga taaagaacaa ctccgcagtg acgatcaggg tcctcttata tgtgaccgtc 7980 aatgatcatg gtaaaataac caggaagacc tacaacttct acctgaagaa gggcctcagc 8040 agggacctca gccttggata cttccagctg ggcaccaccg cactcttcaa gcagtacaca 8100 tacaacacca actacaggtc aaggacagta tcctatgaga acacctacaa tgccaccagc 8160 gtcataaccc agagggtcaa cgtgtctggg gtcaaaggaa ggcagaaggc acctgttgtt 8220 agaattgcaa cactgttgct tgatgaaaac ggcacatcac tacaataaat ctacaatata 8280 tttttaattt ttttaaggtg tggatattgg taggaaggaa actctccaag caaatctatg 8340 aggcgatagt tgtgatgagg cagatagctg aaatgaggaa ggaggtctcg cagcatggct 8400 ttgatgtcag gatgatggaa gtccctggca tgaaggttgc tatcgcaggt gatggggaag 8460 tcaactacct tttcatgtta ctccccttta gggacaagtt taaactaaaa aagcgagatg 8520 tctggttgtt caaaaaactt tcctataaat tcaaggcaag acctttccta gtaacttttg 8580 acaagatgtt atctttctac ccactacacg cccttgaaga aggtggcgaa cactttgaac 8640 tcgatataag gaattcaagg gggctgatgt tttcttttga taccattgtg tcagagcagt 8700 tgcagcaacg gcttgttgtg tagccaccaa atgccacagc aggtaaccct agcgggtgtt 8760 tccctgattt ttttattttg tttatttgtt caattcgtaa cctgcaaaag ccatgtgaac 8820 aacaccaggt ccccaccttc aaaaatagtt aaaattttca atgaatggtc ttttttgttt 8880 tattgtgtta aatttggttt tttgggattt cagcacacta ttctttatgc aacgctataa 8940 cgaaggaatt gaaaccttac gtctttattt gggttttcat ttgggtttgc cccaacccta 9000 tctggtctca ggggtaatga aagtactggc agggtcacca tagggactgt aacctatcca 9060 ctaatccact aatataatgt taatagaata ctgtaatcta cagtagaata ttataatctg 9120 aaagtataaa aaagtattaa caaatatatt gccaaatata tattgtagac tgcaataata 9180 tacaatatgg agcatattga atccaaggta aagtgctata ggcgcaaata caagaggaag 9240 gggaaggaat acactaccac ccagtacgtc atcaacttaa ggaaggaagg ggttgaatcc 9300 cagggcttca agtgcgacga agacgtaatc ataacccata aatctacatt cgaatcccta 9360 atagacatga agaaggacca tgaagccaat cttaaagaga aagagtcact gcagaaaaat 9420 ctaagtgaac ttcaagtaga gttcaacaaa ctaaaaaacg agtataagca cgttaaagcc 9480 ctgctggaca aaaaggaaag ggaagtcaac caccttgaaa atgaggtcag aaggctgcag 9540 aacatgggtc tatttgagat aatcctaaac aaactgcgaa aaaagaaggc aatagaagga 9600 gaagttgaag agggggttaa atagacccca agccctcaag tactacactt ctcatagtag 9660 ctacagagtt tgctcatccc acatttctca cactttggct ttcttggggc acatatgatt 9720 gcggaaaagt ccattaaacc aaggttaaag tccctgcact ttccgccagg tacaagggtc 9780 tccgcaagtt cccacagggc cttgtggttg tagttcaggt tttcatagct tcccccaaag 9840 tacctgttaa taactctcac aaaatttgca tcgaccatag cggctttttt gccaaatgcc 9900 aaacacataa ctgcagcaca agtgtatttg ccaactcctg gtagatctaa aattgccttc 9960 ctatttcggg gcactctgcc cccataatca tttatgacga cccttgccag ttcttttagc 10020 tgttctgccc tttggttaga gagtccgatt tcttttatgt ctttggcgat ttctgatttt 10080 ggcgttttta atatatcctc aaagcacttg tacttaacaa aaaacttgtc atatatcttt 10140 ttaacatgcc ccgcagttgt cctgcgaagt aggatttccg ttattaaaat tacatagggg 10200 tccctcgtat gcctccaagg aaagtcgcgc ctatctgtat tccaaaacgt aagtatggtg 10260 ctaacgaaga ctttcctttt tttattagta gcatcatcca attaaatcca gccccacatg 10320 ttttaaaaat aatttctttt tagcccctaa ttccttagaa accctattat agcaatcttc 10380 taataaatca aataacctaa cttcacccct ccaaagattt tcaactgtat tcaaacctat 10440 agcatcaaca acatccctta aaacagttaa agatacaaaa aggtctccta aaaaactata 10500 gggtccataa atctcctctg gaaacatatc caacggcgaa acagaataac caagtgcagc 10560 ggcaacttta agcctatcaa cttcttccaa actttcagac cttagaagtt ctgctaaaag 10620 aaataatatc tcaggtaggt agtcaacgca gtcctcatat tcaccccgat attggctcaa 10680 atcttcttca aagagtctac aaatattccc tgcccgccta attttaacca ccatagtttt 10740 atttttttta atatctaact atcatagttt atttcagaac agtctaaaaa ttctaataga 10800 tgtcattgag atgagggggt aaataacatg tcaaatttat tgcaagctat catgaatata 10860 aaaagtattc aagaaagaaa cttgggatca tataagggtg tccaagactc caaaaataga 10920 atgaaccaga tgggagttac attagaggtt ttcctaaaag atgctttctg caatacattt 10980 gatatagaaa acaaagacct tgtgtacagt gaatactttt cttaccttgg aaatcaaaat 11040 aacccccccg acatgatcct gaaggggggt gacgcagttg aagtcaagaa gataactgga 11100 ataaaaactt cgattcaact taacagttca taccccaagt caaagctctt tgtttctgac 11160 agcagaataa cagaggcttg caagaactgt gaagattggg aggttaaaga cataatatat 11220 gccataggga ctatcccaaa cagagtcctt aagttaatgt tttttgttta tggggactgt 11280 tacgcggcaa gcccttctat ctaccagaga attgttgaag aagtaaaggg gggtctacat 11340 agtactggcc tagaatttag tgaaacaaac gagctaggta gaattaacag ggtagacccc 11400 ctgggaatta cagacctaag ggtacgtggt atgtggatca tcaaacaccc cataaaagtg 11460 tttaaaaaca taatcccccc agaatcaatt aaaaataata actttaattt aattgccctg 11520 atgaaagcag agaagtataa acaatttcca aaaaaagata ggaaaagaat tgaggcagaa 11580 gataatatcg aagttaccga tgtaaaaata aaagatcctg acaaccctgc caaactatta 11640 gatagcgttc ttgtgaggta tgatgaaata tgaatatgga catagcgtca tttttttcgg 11700 gtgctggagg tctcgactta gggtttacaa aagcaggttt taatattgtc tttgctaacg 11760 acaattggaa agggtgctgg aaaactttcg aaaaaaacca cggaataaaa ataaataaaa 11820 aacccattga atggttaaaa ccctcagaaa tacctgacgt ggttggtttc atagggggac 11880 ccccatgcca gagctggagc ctggcaggtt caatgtgcgg ggcagacgac ccccgtggta 11940 aaacatttta tgcatacgtg gatttagtca aagaaaaaga tcccctattt ttcttggcag 12000 aaaacgtgcc agggatagtt tcaagaacac acctccctga attcaaaaga cttgtaaact 12060 cattcataga catagggtac aacgtagaat ataaggtgct caacgcaaag gactacggcg 12120 tgccacaaga cagaaaaagg gtctttatcg tcgggtaccg tgaggactta aacctaaaat 12180 ttgagtttcc taaaccttta aacaagaaag tgaccctgag ggacgctatt ggtgaccttc 12240 ctgaacccaa gcccgcgctt gaaaaaaaca ggtcaaatgg ggaaaacttg gaagtgccaa 12300 accacgaata catgacaggg acattttcaa gcaggtatat gtcaaggaac agggtaagga 12360 gttgggatga agtttcattt acaattcaag cgggggggcg ccatgcccca tgccacccac 12420 aggctaataa aatgataaag gtgggacctg acaagttcat atttgatcca gaaagtccta 12480 aaccctaccg caggttatcc gtccgcgaat gcgctaggat acaaggtttt cctgatgact 12540 ttatattcta ttataaaaac gttgcagacg gttatactat ggttggtaac gctgttcctg 12600 tgaaattagc agaagaacta gcaaaaaaga taaaaaaaga tttagagggc gttttgaatt 12660 agaattagat ttgtgttatt tttttaaggt cacagagagt aaattgcgag ttgtaaccag 12720 gaacaatacc tcttttaagg tcctctttta aggtcacaga gagtaaattg cgagttgtaa 12780 ccaggaacaa tacctctttt aaggtcacag agagtaaatt gcgagttgta accaggaaca 12840 atacctcaaa tttttttcat gagtaatttt tttcatgagc caactagcca tcaagcctgc 12900 accatttgat gtgaagtcag agagatactg ttcaactgca aaaaggtatt tatattataa 12960 aaaatcaaac ctttcatata taaaaaattt tcaaggtttt ttacatggcg aaatacaaga 13020 agtgttgaac agaaagattt gcctgctttt gctacaaggt gtccctgtta caatgtctct 13080 gttacaagtg ttacaagtag aaattcactc tctgtttccc aagcaatggg ttgttttttg 13140 ttacaagtag aaattcactc tctctgtccc accgtgggcc catgtgctta tatagaaatt 13200 tggtattaat tcttttcaat tagaaatata tatacaataa gaagttatga ttacatatag 13260 aaatgaggtt tcgaattgta aagttgtatt gcggggagct gcagatgttt gagaagagac 13320 ctagactttt caaaaacagg gatgtcctca gcccgctctt tgtgcctgac accctgcagg 13380 acagaaagga agaggtgggt gctatcagcc agtacttggg gtacatcctc gacggcgcca 13440 ccccacccca cctgttgatt gtagggcccc caggatctgg gaagactgtc acgacgaagt 13500 atgtgatcaa cgaa 13514 // |
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