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EBI Dbfetch

ID   X61917; SV 1; linear; genomic DNA; STD; PRO; 12441 BP.
XX
AC   X61917;
XX
DT   19-JUN-1992 (Rel. 32, Created)
DT   09-SEP-2004 (Rel. 81, Last updated, Version 29)
XX
DE   S.enterica rfbJ gene cluster
XX
KW   abe gene; abequose synthase; galactosyltransferase; manB gene; manC gene;
KW   mannose-1-phosphate guanyltransferase; phosphomannomutase; wbaL gene;
KW   wbaP gene; wbaQ gene; wbaR gene; wbaW gene; wbaZ gene; wzx gene; wzy gene.
XX
OS   Salmonella enterica
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
XX
RN   [1]
RP   1-12441
RA   Brown P.K.;
RT   ;
RL   Submitted (03-SEP-1991) to the EMBL/GenBank/DDBJ databases.
RL   P.K. Brown, University of Sydney, Dept of Microbiology, Maze Crescent,
RL   Sydney N S W  2006, AUSTRALIA
XX
RN   [2]
RP   1-12441
RX   DOI; 10.1111/j.1365-2958.1992.tb00859.x
RX   PUBMED; 1379320.
RA   Brown P.K., Romana L.K., Reeves P.R.;
RT   "Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen
RT   (strain M67): the genetic basis of the polymorphism between groups C2 and
RT   B";
RL   Mol. Microbiol. 6(10):1385-1394(1992).
XX
RN   [3]
RX   PUBMED; 7684736.
RA   Liu D., Haase A.M., Lindqvist L., Lindberg A.A., Reeves P.R.;
RT   "Glycosyl transferases of O-antigen biosynthesis in Salmonella enterica:
RT   identification and characterization of transferase genes of groups B, C2,
RT   and E1";
RL   J. Bacteriol. 175(11):3408-3413(1993).
XX
RN   [4]
RX   DOI; 10.1016/0168-9525(93)90067-R
RX   PUBMED; 8434412.
RA   Reeves P.;
RT   "Evolution of Salmonella O antigen variation by interspecific gene transfer
RT   on a large scale";
RL   Trends Genet. 9(1):17-22(1993).
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..12441
FT                   /organism="Salmonella enterica"
FT                   /strain="group C2, serovar muenchen M67"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:28901"
FT   CDS             138..1019
FT                   /transl_table=11
FT                   /gene="abe"
FT                   /product="abequose synthase"
FT                   /db_xref="GOA:Q00329"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q00329"
FT                   /protein_id="CAA43918.1"
FT                   /translation="MLDVNKKILMTGATSFVGTHLLHSLIKEGYSIIALKRPITEPTII
FT                   NTLIEWLNIQDIEKICQSSMNIHAIVHIATDYGRNRTPISEQYKCNVLLPTRLLELMPA
FT                   LKTKFFISTDSFFGKYEKHYGYMRSYMASKRHFVELSKIYVEEHPDVCFINLRLEHVYG
FT                   ERDKAGKIIPYVIKKMKNNEDIDCTIARQKRDFIYIDDVVSAYLKILKEGFNAGHYDVE
FT                   VGTGKSIELKEVFEIIKKETHSSSKINYGAVAMRDDEIMESHANTSFLTRLGWSAEFSI
FT                   EKGVKKMLSMKE"
FT   CDS             1019..2359
FT                   /transl_table=11
FT                   /product="hypothetical protein with 12 predicted
FT                   transmembrane segments which possibly functions in export
FT                   of O-antigen"
FT                   /note="wzx"
FT                   /note="Referred to as orf12.6 in reference [2]"
FT                   /db_xref="UniProtKB/TrEMBL:Q00339"
FT                   /citation=[4]
FT                   /protein_id="CAA43919.1"
FT                   /translation="MNRIIRMLGVDKAIRYVIFGKIISVLTGLLLIMLISHHLSKDAQG
FT                   YYYTFNSVVALQIIFELGLSTVIIQFASHEMSALKYDYSERDIIGESKNKQRYLSLFRL
FT                   AIKWYAVIALLIILIVGPIGYVFFTQKEGLGVPWQGAWLLLTIVTAFNIFLVSVLSVAE
FT                   GSGLITDVNKMRMYQSLLAGILAVSLLISGFGLYATSAIAISGTIIFSIFSYKYFKKIF
FT                   LQSLKHKNKYTEGGISWVNEIFPMQWRIALSWMSGYFIYFVMTPIAFKYFGAIYAGQLG
FT                   MSLTLCNMVMATGLAWISTKYPKWGVMVSNKQLAELSKSFKSAVMQSSFFVLTGLTGVY
FT                   ISLWLLKLSGSNIGERFLGLQDFFFLSLAIIGNHIVACFATYIRAHKTEKMTLASCIMA
FT                   LLTITTMLFVAYLEYSRFYMLMYAALTWLYFVPQTYIIFKRFKSSYE"
FT   CDS             2352..3314
FT                   /transl_table=11
FT                   /note="wbaR"
FT                   /db_xref="InterPro:IPR001173"
FT                   /db_xref="UniProtKB/TrEMBL:Q00337"
FT                   /protein_id="CAA43909.1"
FT                   /translation="MSKKPLLTIAIPTYNRSSCLARLLDSIIQQENYCHDELEVIVCDN
FT                   ASTDETARIAKSGLDKIRNSTYHLNEENLGMDGNFQKCFELSNGKYLWMIGDDDLIVKN
FT                   GISKVFSILKSRPALDMVYVNSAAKTELNYNADVRTSFYTNDVDFISDVKVMFTFISGM
FT                   ICKKTDAIVKAVGIFSPQTTGKYLMHLTWQLPLLKQGGEFAVIHNNIIEAEPDNSGGYH
FT                   LYKVFSNNLATIFDVFYPREHRVSKRVRASACLFLLNFIGDEDKTKNFATNNYLRDCDS
FT                   AFIDLIIYKYGLRFFYLYPKTVPLFRKIKYIIKTVLMRK"
FT   CDS             3361..3975
FT                   /transl_table=11
FT                   /note="wbaL"
FT                   /note="orf14.9 possibly encodes an acetyltransferase"
FT                   /db_xref="GOA:Q00480"
FT                   /db_xref="InterPro:IPR001451"
FT                   /db_xref="UniProtKB/TrEMBL:Q00480"
FT                   /protein_id="CAA43910.1"
FT                   /translation="MFVYSLRLKLNLIISLLSKVRRKSKAKFLVLLSGYDFKMVGKNFK
FT                   LNVKPYSAKNNTSSKWGSMRVGDNCWIEAVYNYGDEKFEPYLYIGDRICLSDNVHISCV
FT                   SCLILENDILIGSKVYIGDHSHGSYKVCSPKIEPPANKPLGDIAPIKIGNCCWIGDNAV
FT                   ILAGSEICDGCVIAANSVVKDLKVDKPCLIGGVPAKVIKVF"
FT   CDS             3977..5020
FT                   /transl_table=11
FT                   /product="rhamnosyl transferase"
FT                   /note="wbaQ"
FT                   /note="Referred to as orf15.6 in reference [2]"
FT                   /db_xref="GOA:Q00482"
FT                   /db_xref="InterPro:IPR001173"
FT                   /db_xref="UniProtKB/TrEMBL:Q00482"
FT                   /citation=[3]
FT                   /protein_id="CAA43911.1"
FT                   /translation="MNVFISICIPSYNRAEFLEPLLDSIYNQDYCLKNNDFEVIVCEDK
FT                   SPQRDEINSIIENYKAKNNKQNLYVNFNEDNLGYDKNLKKCISLTTGKYCMIMGNDDLL
FT                   ADGALSKIVKVLKANPEIVLATRAYGWFKENPNELCDTVRHLTDDTLFQPGADAIKFFF
FT                   RRVGVISGFIVNAEKAKKLSSDLFDGRLYYQMYLAGMLMAEGQGYYFSDVMTLSRDTEA
FT                   PDFGNAGTEKGVFTPGGYKPEGRIHMVEGLLLIAKYIEDTTKIDGVYAGIRKDLANYFY
FT                   PYIRDQLDLPLYTYIKMINKFRKMGFSNEKLFYVHAFLGYVLKRRGYDALIKYIRSKKG
FT                   GTPRLGI"
FT   CDS             5114..6313
FT                   /transl_table=11
FT                   /gene="wzy"
FT                   /product="O antigen polymerase"
FT                   /db_xref="GOA:Q00474"
FT                   /db_xref="InterPro:IPR007016"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q00474"
FT                   /protein_id="CAA43912.1"
FT                   /translation="MLPFPPGAILRDVLNVFFVALVLVRFVIDRKKTYFPLVFTIFSWS
FT                   AVILWVIALTIFSPDKIQAIMGGRSYILFPAVFIALVILKVSYPQSLNIEKIVCYIIFL
FT                   MFMVATISIIDVLMNGEFIKLLGYDEHYAGEQLNLINSYDGMVRATGGFSDALNFGYML
FT                   TLGVLLCMECFSQGYKRLLMLIISFVLFIAICMSLTRGAILVAALIYALYIISNRKMLF
FT                   CGITLFVIIIPVLAISTNIFDNYTEILIGRFTDSSQASRGSTQGRIDMAINSLNFLSEH
FT                   PSGIGLGTQGSGNMLSVKDNRLNTDNYFFWIALETGIIGLIINIIYLASQFYSSTLLNR
FT                   IYGSHCSNMHYRLYFLFGSIYFISAALSSAPSSSTFSIYYWTVLALIPFLKLTNRRCTR
FT                   "
FT   CDS             6313..7323
FT                   /transl_table=11
FT                   /product="second mannosyl transferase"
FT                   /note="wbaW"
FT                   /note="Referred to as orf17.9 in reference [2]"
FT                   /db_xref="GOA:Q00481"
FT                   /db_xref="InterPro:IPR001296"
FT                   /db_xref="UniProtKB/TrEMBL:Q00481"
FT                   /citation=[3]
FT                   /protein_id="CAA43913.1"
FT                   /translation="MNNKKVLMDISWSNKGGIGRFTDEISKLLCDISKEELYRKCASPL
FT                   APLGLAVNIFLRKKTDVVFLPGYIPPLFCSKKFIITIHDLNHLDLNDNSSLFKRLFYNF
FT                   IIKRGCRKAYKIFTVSNFSKERIVAWSGVNPNKIVTVYNGVSSLFNADVKPLNLGYKYL
FT                   LCVGNRKTHKNEKCVISAFAKADIDPSIKLVFTGNPCNDLEKLIIQHGLSERVKFFGFV
FT                   SEKDLPSLYKGSLGLVFPSLYEGFGLPVVEGMACGIPVLTSLTSSLPEVAGDAAILVDP
FT                   LSEDAITKGISRLINDSELRKHLIQKGLLRAKRFNWQNVVSEIEMVLTEACDGNK"
FT   CDS             7310..8467
FT                   /transl_table=11
FT                   /product="first mannosyl transferase"
FT                   /note="wbaZ"
FT                   /note="Referred to as orf18.9 in reference [2]"
FT                   /db_xref="GOA:Q00483"
FT                   /db_xref="InterPro:IPR001296"
FT                   /db_xref="UniProtKB/TrEMBL:Q00483"
FT                   /citation=[3]
FT                   /protein_id="CAA43914.1"
FT                   /translation="MEINEIKISLVHEWLLSYAGSEQVSSAILHVFPEAKLYSVVDFLT
FT                   DEQRRHFLGKYATTTFIQNLPKAKKFYQKYLPLMPLAIEQLDLSDANIIISSAHSVAKG
FT                   VISGPDQLHISYVHSPIRYAWDLQHQYLNESNLNKGIKGWLAKWLLHKIRIWDSRTANG
FT                   VDHFIANSQYIARRIKKVYRREASVIYPPVDVDNFEVKNEKQDYYFTASRMVPYKRIDL
FT                   IVEAFSKMPEKKLVVIGDGPEMKKIKSKATDNIKLLGYQSFPVLKEYMQSARAFVFAAE
FT                   EDFGIIPVEAQACGTPVIAFGKGGALETVRPLGVEEPTGIFFKEQNIASLHEAVSEFEK
FT                   NASFFTSQACRKNAEKFSRSRFEQEFKNFVNEKWNLFKTEQIIKR"
FT   CDS             8482..9903
FT                   /transl_table=11
FT                   /gene="manC"
FT                   /product="mannose-1-phosphate guanyltransferase"
FT                   /db_xref="GOA:Q00473"
FT                   /db_xref="InterPro:IPR014710"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q00473"
FT                   /protein_id="CAA43915.1"
FT                   /translation="MSKLIPVIMAGGIGSRLWPLSREEHPKQFLSVDGELSMLQNTIKR
FT                   LTPLLAGEPLVICNDSHRFLVAEQLRAINKLANNIILEPVGRNTAPAIALAAFCSLQNV
FT                   VDEDPLLLVLAADHVIRDEKVFLKAINHAEFFATQGKLVTFGIVPTQAETGYGYICRGE
FT                   AIGEDAFSVAEFVEKPDFDTARHYVESEKYYWNSGMFLFRASSYLQELKDLSPDIYQAC
FT                   ENAVGSINPDLDFIRIDKEAFAMCPSDSIDYAVMEHTRHAVVVPMNAGWSDVGSWSSLW
FT                   DISKKDPQRNVLHGDIFAYNSKDNYIYSEKSFISTIGVNNLVIVQTADALLVSDKDSVQ
FT                   DVKKVVDYLKANNRNEHKKHLEVFRPWGKFSVIHSGDNYLVKRITVKPGAKFAAQMHLH
FT                   RAEHWIVVSGTACITKGEEIFTISENESTFIPANTVHTLKNPATIPLELIEIQSGTYLA
FT                   EDDIIRLEKHSGYLE"
FT   CDS             9911..11347
FT                   /transl_table=11
FT                   /gene="manB"
FT                   /product="phosphomannomutase"
FT                   /db_xref="GOA:Q00330"
FT                   /db_xref="InterPro:IPR016066"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q00330"
FT                   /protein_id="CAA43916.1"
FT                   /translation="MKNIYNTYDVINKSGINFGTSGARGLVTDFTPEVCARFTISFLTV
FT                   MQQRFSFTTVALAIDNRPSSYAMAQACAAALQEKGIKTVYYGVIPTPALAHQSISDKVP
FT                   AIMVTGSHIPFDRNGLKFYRPDGEITKDDENAIIHVDASFMQPKLEQLTISTIAARNYI
FT                   LRYTSLFPMPFLKNKRIGIYEHSSAGRDLYKTLFKMLGATVVSLARSDEFVPIDTEAVS
FT                   EDDRNKAITWAKKYQLDAIFSTDGDGDRPLIADEYGNWLRGDILGLLCSLELAADAVAI
FT                   PVSCNSTISSGNFFKHVERTKIGSPYVIAAFAKLSANYNCIAGFEANGGFLLGSDVYIN
FT                   QRLLKALPTRDALLPAIMLLFGSKDKSISELVKKLPARYTYSNRLQDISVKTSMSLINL
FT                   GLTDQEDFLQYIGFNKHHILHSDVTDGFRITIDNNNIIHLRPSGNAPELRCYAEADSQE
FT                   DACNIVETVLSNIKSKLGRA"
FT   CDS             11426..>12441
FT                   /transl_table=11
FT                   /gene="wbaP"
FT                   /product="galactosyl transferase"
FT                   /db_xref="GOA:Q00331"
FT                   /db_xref="InterPro:IPR003362"
FT                   /db_xref="UniProtKB/TrEMBL:Q00331"
FT                   /protein_id="CAA43917.1"
FT                   /translation="MDRFDNKYNPNLCKILLAISDLLFFNVALWASLGVVYLIFDEVQR
FT                   FVPQEQLDNRFISHFILSIVCVGWFWVRLRHYTYRKPFWYELKEVIRTIVIFAVFDLAL
FT                   IAFTKWQFSRYVWVFCWTFAIILVPFFRALTKHLLNKLGIWKKKTIILGSGQNARGAYS
FT                   ALQSEEMMGFDVIAFFDTDASDAEINMLPVIKDTETIWDLNRTGDVHYILAYEYTELEK
FT                   THFWLRELSKHHCRSVTVVPSFRGLPLYNTDMSFIFSHEVMLLRIQNNLAKRSSRFLKR
FT                   TFDIVCSIMILIIASPLMIYLWYKVTRDGGPAIYGHQRVGRHGKLFPCYKFRSMVMNS"
XX
SQ   Sequence 12441 BP; 3887 A; 1876 C; 2518 G; 4160 T; 0 other;
     gttgacaaat accgaccgta taatgaatca aacgttctgg attggtattt atccaggctt        60
     gactacagag catttagatt atgtcgtaag taagtttgaa gaattttttg gtttaaattt       120
     ctaattttta ggataggatg cttgatgtga ataagaaaat cctaatgact ggcgctacta       180
     gctttgtagg tacccatcta ctacatagtc tcataaagga aggttatagt attattgcat       240
     taaagcgtcc tataaccgag ccaacgatta tcaatacctt gattgaatgg ttgaatatac       300
     aagatataga aaaaatatgt caatcatcta tgaatattca tgcgattgtc catattgcaa       360
     cagactatgg tcgaaacaga acccctatat ctgaacaata taaatgtaat gtcctattac       420
     caacaagact gcttgagtta atgccagcgc ttaaaacgaa attctttatt tctactgact       480
     ctttttttgg gaaatatgag aagcactatg gatatatgcg ttcttacatg gcatctaaaa       540
     gacattttgt agaactatca aaaatatacg tagaggaaca tccagacgtt tgttttataa       600
     atttacgttt agaacatgtt tacggtgaga gggataaagc aggtaaaata atcccgtatg       660
     ttatcaaaaa aatgaaaaac aatgaagata ttgattgtac gatcgccagg cagaaaagag       720
     attttattta tatagacgat gttgtttcgg cctatttgaa aattttaaag gagggtttta       780
     acgctggaca ctatgatgtc gaggtgggga ctggaaaatc gatagagcta aaagaagtgt       840
     ttgagataat aaaaaaagaa acgcatagta gtagtaagat aaattatggt gcagttgcga       900
     tgcgtgatga tgagattatg gagtcacatg caaatacctc tttcttgact cgattaggtt       960
     ggagtgccga gttttctatt gagaagggtg tgaaaaaaat gttgagtatg aaagagtaat      1020
     gaatcgtatt attagaatgt taggtgtaga taaagcaatt cgttatgtta tttttggtaa      1080
     gataatatct gtattaacgg gtttactgtt aataatgtta atatcacacc atttatctaa      1140
     agacgcacag ggctattatt atacatttaa ttcagtagtg gcactacaga taatatttga      1200
     attggggcta tcaacggtaa tcattcaatt cgctagccat gaaatgtcag cgttaaaata      1260
     tgattattct gaacgagata ttataggtga aagtaaaaat aagcaacgtt acctatcgtt      1320
     atttcggttg gcaataaaat ggtatgcagt aatagctttg ctaataatat taatagtcgg      1380
     tcccatcggg tatgtttttt ttacgcaaaa agaaggctta ggtgtacctt ggcaaggggc      1440
     atggttatta ttaacaatag ttacagcttt taatattttt cttgtttctg tactttctgt      1500
     cgctgaaggg agtgggttaa ttactgatgt gaataaaatg agaatgtatc agtcgctgtt      1560
     agctggtata ttggcagtaa gcttacttat tagtggcttt ggactatatg ctacgtctgc      1620
     aatagctatt tcagggacta tcatattctc catattttca tataagtatt ttaaaaaaat      1680
     tttcctgcaa tctttaaagc ataaaaataa atatactgaa ggtggtattt catgggttaa      1740
     tgaaatattt cctatgcaat ggcgaattgc tctaagttgg atgtcagggt attttattta      1800
     ttttgttatg acccccattg cattcaaata tttcggggct atatatgcag ggcagttagg      1860
     gatgtcttta acattatgca atatggtaat ggctacgggc ctggcttgga tatccactaa      1920
     atatccaaaa tggggagtaa tggtttccaa caaacagctt gcggaactga gtaaatcgtt      1980
     caaaagtgca gtaatgcaat catccttttt tgtcttgaca ggattaactg gtgtatacat      2040
     ttcattatgg ttattgaaat tatctggttc aaacattggc gagcggtttt tgggattgca      2100
     ggattttttc tttttatctt tagcaattat tggtaatcac attgtagctt gctttgcaac      2160
     ctatataaga gcgcataaaa ctgaaaaaat gacattggca tcatgtataa tggctctctt      2220
     gactataact acaatgttgt ttgttgcata tttagagtac tcgaggttct acatgttaat      2280
     gtatgcagca ctaacgtggt tatattttgt tcctcaaact tatataatct ttaaaagatt      2340
     caagagttct tatgagtaaa aaacctcttc ttactattgc tattccgaca tataaccgct      2400
     cttcatgttt ggctcgttta cttgatagta taattcaaca ggagaactat tgtcatgatg      2460
     aactcgaggt tattgtttgt gataatgctt caacagatga aacagcaaga atagccaaga      2520
     gtggcttaga taaaataaga aatagtactt atcatctaaa tgaagaaaac ttaggaatgg      2580
     atggtaactt ccagaaatgt tttgagttat caaatggaaa atatctttgg atgattggcg      2640
     atgatgatct aatagtcaaa aatggtattt cgaaggtttt ttcgatatta aagtcccggc      2700
     ctgcattaga tatggtgtat gtaaattcag cagcaaagac tgagttaaac tataatgctg      2760
     atgtgaggac gtcattctac acaaatgatg tagattttat ttcagacgtg aaagttatgt      2820
     tcacgtttat ttctggaatg atatgtaaga aaactgatgc aattgtcaaa gccgttggta      2880
     ttttcagtcc gcaaactact ggaaaatatc ttatgcattt aacatggcaa ttgccattac      2940
     ttaaacaggg tggagagttc gcagttatcc ataataatat aattgaggct gagccagata      3000
     attcaggtgg atatcattta tataaggttt tttctaataa tcttgcgaca atctttgatg      3060
     ttttttatcc cagagagcac cgtgtaagta aaagagttcg cgcatcagca tgtttattct      3120
     tacttaactt cataggcgat gaagataaaa ccaaaaattt tgctacaaat aattatttaa      3180
     gagattgcga tagtgcattt atagatttaa ttatatataa atatgggctt aggtttttct      3240
     atctatatcc taaaactgtg cctttattta gaaaaataaa atatattata aagacggttt      3300
     taatgcggaa ataaaaatta ttcaagatgg tttgctgaaa acgacttata ggactatcta      3360
     atgtttgtct atagtttaag attaaaatta aatcttatca tatcattatt gagtaaagtt      3420
     aggcggaaat caaaagcaaa gtttcttgtt ctgcttagcg gatatgattt taaaatggtt      3480
     gggaagaatt ttaaattgaa tgtcaaacct tactctgcaa aaaataacac ctcttccaaa      3540
     tggggtagta tgcgggttgg tgataactgc tggattgaag ctgtatataa ttatggtgat      3600
     gaaaaatttg aaccttattt gtacataggt gatcgtatat gtttaagtga taatgttcat      3660
     atttcttgcg tatcatgttt aattttagaa aacgatatat taattggtag caaagtttat      3720
     ataggcgatc atagccatgg cagttataaa gtatgcagtc cgaaaataga accgccagca      3780
     aataagccat taggtgatat tgctcctatt aaaataggta attgctgctg gattggagat      3840
     aatgcagtaa ttctggctgg tagtgaaatt tgtgatggct gtgtaatcgc agctaattca      3900
     gtcgtcaagg atttaaaagt cgataagcca tgtttaattg gtggggttcc tgctaaagta      3960
     ataaaggtat tttaaaatga atgtttttat cagtatttgt ataccgtctt ataatagagc      4020
     tgagttttta gagccactac tggatagcat atataatcaa gattattgtt taaagaataa      4080
     tgattttgag gtcattgttt gtgaagataa atctccacag agagatgaga taaactctat      4140
     tatcgaaaac tataaagcaa aaaataataa acaaaatctt tatgttaatt tcaatgaaga      4200
     taatttaggc tatgataaga atttaaaaaa atgcattagt ttgacgacag gtaaatattg      4260
     catgatcatg ggcaacgatg atctattagc agatggagcg ttatcaaaaa tagtgaaagt      4320
     tttgaaggct aatcctgaaa ttgtattggc tacgcgagcg tatggttggt ttaaggaaaa      4380
     tccgaatgag ttatgtgata ctgttcgtca tttaacagac gatactttat ttcagccggg      4440
     ggctgatgcc attaaatttt tcttccgtag agttggagtt atttcaggct ttattgtcaa      4500
     tgctgaaaaa gcaaaaaaac tatcgagtga tttatttgat gggcgtttat attatcaaat      4560
     gtaccttgct ggtatgctaa tggctgaagg tcagggatac tattttagcg acgtgatgac      4620
     attgtcgagg gatacagagg ctcctgactt tggtaacgct ggaactgaaa aaggagtttt      4680
     caccccgggg gggtataaac cagagggccg tatacatatg gttgaaggct tgttgctaat      4740
     tgcaaaatat atagaagata caacaaaaat tgatggcgtt tatgctggaa ttagaaaaga      4800
     cttagcgaac tatttttatc cttatattcg agatcaactc gacttgcctc tttatactta      4860
     tattaaaatg ataaataaat ttcggaaaat gggattttca aatgaaaagc ttttctatgt      4920
     gcatgccttt ttagggtatg tactaaaacg gaggggctat gatgctttaa ttaaatacat      4980
     tcgtagcaaa aaaggcggta ctccgcgtct tggtatttaa cctccacttt caaaaaatgt      5040
     tatgaatata cttcttgctg cgatattagg cgttaactta ttttctccat atattagttc      5100
     gtggatggtg ggtatgctgc catttccacc aggagcaatc ctaagggatg tactcaatgt      5160
     attttttgtg gcgttagtgc tagttcgatt tgtcattgat aggaaaaaaa cttatttccc      5220
     gttggttttt actatttttt catggtcggc ggtaatacta tgggtaatag cgttaactat      5280
     attctcaccg gataaaattc aagcaattat gggggggcgg agttatattt tattcccggc      5340
     agttttcata gcattagtga ttttaaaagt atcatacccg caatccttaa atattgaaaa      5400
     aatagtttgc tacataattt ttctaatgtt tatggttgcg acaatatcta ttattgatgt      5460
     actaatgaat ggagagttca ttaaattgct cggatatgat gagcattatg caggagaaca      5520
     attaaactta attaatagct atgatgggat ggtccgggct acaggcggtt ttagtgatgc      5580
     tctcaatttt ggatatatgc tcacattagg tgttttgtta tgtatggagt gtttttccca      5640
     aggatataaa agattattga tgcttattat tagttttgtg ctatttatag cgatctgcat      5700
     gagtcttact agaggagcaa tacttgttgc tgcgcttatt tacgcacttt atataatttc      5760
     aaatcggaag atgctttttt gtggaataac tttatttgta ataattatac ccgttttagc      5820
     aatttctact aatatttttg acaactatac agaaattttg atcggcaggt ttacagattc      5880
     gtctcaggca tcgcgtggat ctacacaggg gcggatagat atggcaatta attcattaaa      5940
     cttcctgtca gaacatccat caggtatagg tctgggtact caaggttcag gaaacatgct      6000
     ttcggtaaaa gataataggt taaatacgga taattatttt ttctggatcg cccttgagac      6060
     tggtattatt ggcttaatca taaatattat ttatctggca agtcaatttt attcttcaac      6120
     tttactaaat agaatatatg gcagtcattg tagcaatatg cactatagat tatattttct      6180
     ctttggaagt atatatttta taagtgcagc gttaagttca gcaccttcgt catcaacttt      6240
     ttctatatat tattggacag ttttagcttt gattccattt ttaaaattaa caaatagacg      6300
     gtgcacgcga taatgaataa taaaaaggtt ttgatggata ttagttggtc taataaaggg      6360
     gggattggac gttttactga tgaaatttct aaactactat gtgatatatc taaggaggaa      6420
     ctatatagaa aatgtgcttc tccgctggcc ccattaggtt tagcagtcaa tatttttctg      6480
     cgaaagaaaa ctgatgtggt ttttcttcct ggctatattc caccactttt ttgttcgaaa      6540
     aagttcataa taacaataca tgatctaaat catctggatt taaatgataa ttcctctctt      6600
     tttaagaggt tattttataa ttttataata aagcgcggtt gtagaaaagc atataaaata      6660
     tttacagttt cgaatttttc aaaagaaaga atagtagcat ggtcaggtgt aaaccctaat      6720
     aaaatagtca cggtatataa tggggtatct agtctattta atgccgatgt aaaaccattg      6780
     aatttaggct ataaatattt gctatgtgta ggaaacagaa aaactcataa gaatgagaag      6840
     tgtgttatat ctgcctttgc caaagcagat attgatccat caataaaact cgtttttact      6900
     ggtaatcctt gtaatgattt agaaaaacta ataatacaac atggtttaag tgaacgtgta      6960
     aagttctttg ggttcgtgtc tgaaaaagat ttaccatcgt tatataaggg ctcgttagga      7020
     ttagttttcc cttctttata tgaaggtttt ggattacctg tagtggaggg catggcctgt      7080
     ggtattcctg tattaacttc tctaacttca tcattgccag aggtggctgg agatgcagcg      7140
     attcttgtcg accctctttc ggaagatgct attactaaag gaatttcgag gttaattaat      7200
     gattctgaac ttcgtaagca tttaatccaa aaggggcttt tgcgggcaaa gaggttcaat      7260
     tggcaaaacg tggttagtga gattgaaatg gtactgacag aggcatgtga tggaaataaa      7320
     tgaaataaaa atatctctcg ttcatgagtg gttattaagt tatgcaggct ccgaacaggt      7380
     atcatctgcc atcctgcatg tttttcctga agcgaagtta tattcggtgg ttgattttct      7440
     aacggatgaa caaagaagac attttctggg gaaatatgcg actaccacat ttattcaaaa      7500
     tttacctaaa gctaaaaaat tttaccagaa atatttacca ctaatgccac tggctattga      7560
     acaacttgat ttatcagatg ctaatatcat cattagtagc gcccattccg ttgcaaaagg      7620
     tgttatttcc ggaccagatc agcttcacat tagctatgtt cattctccta ttcgatatgc      7680
     gtgggattta cagcatcagt accttaatga gtctaacctg aataaaggaa ttaaaggttg      7740
     gttagcaaaa tggcttcttc acaaaatacg aatttgggat tctcgaaccg caaatggggt      7800
     tgatcatttt atagctaatt ctcaatatat cgcgcgtaga attaaaaaag tatacagacg      7860
     tgaggcttca gttatatatc cgcctgtaga tgtggataat tttgaagtaa aaaatgaaaa      7920
     gcaagactat tatttcacag catcccgtat ggtaccctac aaacgtattg atcttattgt      7980
     cgaagccttt agtaaaatgc cggaaaagaa attagtagtt attggtgatg gaccggagat      8040
     gaaaaaaata aagagcaagg ctacagacaa tataaaattg ctcggttatc aatcttttcc      8100
     tgttttaaaa gagtatatgc agagcgccag ggcgtttgtt tttgcagcgg aagaggactt      8160
     tggaataata cctgtcgaag ctcaagcttg cggtacccct gttattgcct ttgggaaggg      8220
     tggggcctta gaaaccgttc gcccactagg tgtagaggaa ccgactggca ttttcttcaa      8280
     ggaacagaat attgcttctt tgcatgaagc tgttagtgaa tttgaaaaaa atgcatcatt      8340
     ttttacatct caggcttgta gaaaaaatgc agaaaaattt tctcgatcaa gatttgaaca      8400
     agaatttaag aactttgtta atgaaaagtg gaatcttttc aaaacagaac agattattaa      8460
     acgttaatta tggtttattg aatgtctaaa ttaataccag taataatggc cggtgggatt      8520
     ggtagccgtt tgtggccact ttcacgtgaa gagcatccga aacagttttt aagcgtagat      8580
     ggtgaattat ctatgctgca aaacaccatt aaaagattga ctcctctttt ggctggagaa      8640
     cctttagtca tttgtaatga tagtcaccgc ttccttgtcg ctgaacaact tcgagctata      8700
     aataaactag caaataacat catattagag ccagtggggc gtaatacagc cccagctata      8760
     gcgctggccg ctttttgttc acttcagaat gtcgtcgatg aagacccgct tttgcttgtc      8820
     cttgctgcgg atcatgtcat ccgcgatgag aaagtgtttc ttaaagctat caatcacgct      8880
     gaattttttg caacacaagg taagctagta acgtttggta ttgtacccac acaggccgaa      8940
     actggctacg gttatatttg tagaggtgaa gcaatcgggg aagatgcttt ttctgtagcc      9000
     gaatttgtag agaagcctga tttcgataca gcgcgtcatt atgtagaatc agagaaatat      9060
     tattggaaca gcggtatgtt cctatttcgt gcaagtagtt acttacaaga attaaaggat      9120
     ctgtcccccg atatttacca agcatgtgaa aatgcggtag ggagtattaa tcctgatctt      9180
     gattttatcc gtattgataa agaagcattc gcaatgtgcc ctagtgattc tatcgattat      9240
     gcggtaatgg aacatactag gcatgcagtt gtcgtaccga tgaatgccgg ctggtcagat      9300
     gtggggtcat ggtcttcact gtgggatatt tctaagaaag atccacaacg taatgtatta      9360
     catggcgata tttttgcata taatagtaaa gataattata tctattctga aaaatcgttt      9420
     attagtacaa tcggagtaaa taatttagtt atcgtgcaga cagcagatgc attattagta      9480
     tctgataaag attcagtcca ggatgttaaa aaagttgttg attatttaaa agctaataat      9540
     agaaacgaac ataaaaaaca tttagaggtt ttccgaccgt ggggaaaatt tagcgtaatt      9600
     catagtggcg ataattattt agttaaaaga ataactgtta aaccaggcgc gaagtttgct      9660
     gctcagatgc atctccatcg tgctgagcat tggatagtgg tatctggtac tgcttgtatt      9720
     actaaggggg aagaaatttt tacaatttcg gagaatgaat caacatttat acctgctaat      9780
     acagttcata cgttaaaaaa ccccgcgact attccattag aactaataga aattcaatct      9840
     ggcacctatc ttgcggagga tgatattatt cgcctggaga aacattctgg atatctggag      9900
     taatgaattg atgaaaaata tatataatac ttacgatgtt atcaacaaat ctggaattaa      9960
     ttttggaacc agtggtgccc gcggccttgt taccgatttt acacccgaag tttgcgcacg     10020
     atttaccatt tcctttttga cagtaatgca gcaaagattc tcatttacaa cggttgcgct     10080
     cgcaattgat aatcgtccaa gcagttacgc gatggctcaa gcttgtgccg ctgctttgca     10140
     agaaaaagga attaaaaccg tttactatgg cgtaattcca acacctgctt tagctcatca     10200
     atcaatttcc gataaagtac ctgcaatcat ggttactggc agtcatatcc cttttgaccg     10260
     taatggcctg aaattttata gaccagatgg tgaaattact aaagatgatg agaatgctat     10320
     tattcatgtt gatgcctcat ttatgcagcc taagcttgaa caattgacaa tttccacaat     10380
     cgctgctaga aattatattc tacgatatac ctcattattt ccaatgccat tcttgaaaaa     10440
     taagcgcatt ggaatttatg agcattctag tgcgggtcgt gatctctata agacgttatt     10500
     caaaatgttg ggtgctacag ttgttagttt agcaaggagc gacgaatttg ttcctattga     10560
     tactgaagct gtaagtgaag atgatagaaa taaagcaatc acatgggcaa aaaaatatca     10620
     gttagatgct atattttcaa ctgatggtga tggagatcgc cctctgatag ctgacgaata     10680
     tggaaattgg ttaagaggag atatattagg ccttctgtgc tctctcgaat tagctgctga     10740
     tgcagtcgct attcctgtaa gctgcaacag tacaatctca tctggtaact tttttaaaca     10800
     tgtggaacga acaaagattg gttcacccta tgtgattgca gcatttgcta aattatctgc     10860
     aaactataat tgtatagctg gttttgaagc gaatggtggc tttctgctag gtagcgatgt     10920
     ttatattaat cagcgtttac ttaaggcatt accaacacgt gatgctttat tacctgccat     10980
     tatgcttctg tttggtagca aggacaaaag tattagtgag cttgttaaaa aacttcctgc     11040
     tcgctatacc tattcaaaca gattacagga tataagtgtt aaaacaagta tgtctttaat     11100
     aaatcttggt ctgacagatc aagaggattt tttgcagtat attggtttta ataaacatca     11160
     tatattacat tctgatgtta ctgatggctt tagaatcact atcgataaca acaatattat     11220
     tcatttacga ccttcaggca atgcccctga gttgcgttgc tatgcggagg ctgactcgca     11280
     agaggatgca tgtaatattg ttgaaactgt tctctctaat atcaaaagca aactgggtag     11340
     agcttaatgc tgttgataat agagcgtttc tttccagtaa tactttgtct ggttatctgg     11400
     tacccaagtt gagggtgaga attaaatgga tcgttttgat aataagtata acccaaattt     11460
     atgcaaaata ttattggcta tatcagattt actgtttttt aatgtagcct tatgggcatc     11520
     gttaggagtt gtatatttaa tctttgatga agttcagcga tttgtaccac aagagcaatt     11580
     agataatcga tttatatcac attttattct atctatagta tgcgttggat ggttttgggt     11640
     tcgactgcgt cactatacat atcgaaagcc attctggtat gagttgaaag aggttattcg     11700
     tactatcgtt atttttgctg tgtttgattt ggctttaatt gcgtttacaa aatggcagtt     11760
     ttcacgctat gtctgggtgt tttgttggac ttttgccata atcctggtgc ctttttttcg     11820
     cgcacttaca aagcatttat tgaacaagct aggtatctgg aagaaaaaaa ctatcatcct     11880
     tgggagcgga cagaatgctc gtggtgcata ttctgcgctg caaagtgagg agatgatggg     11940
     gtttgatgtt atcgcttttt ttgatacgga tgcgtcagat gctgaaataa atatgttgcc     12000
     ggtgataaag gacactgaga ctatttggga tttaaatcgt acaggtgatg tccattatat     12060
     ccttgcttat gaatacaccg agttggagaa aacacatttt tggctacgtg aactttcaaa     12120
     acatcattgt cgttctgtta ctgtcgtccc ctcgtttaga ggattgccat tatataatac     12180
     tgatatgtct tttatcttta gccatgaagt tatgttatta aggatacaaa ataacttggc     12240
     taaaaggtcg tcccgttttc tcaaacggac atttgatatt gtttgttcaa taatgattct     12300
     tataattgca tcaccactta tgatttatct gtggtataaa gttactcgag atggtggtcc     12360
     ggctatttat ggtcaccagc gagtaggtcg gcatggaaaa ctttttccat gctacaaatt     12420
     tcgttctatg gttatgaatt c                                               12441
//


  
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