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EBI Dbfetch

ID   X52291; SV 1; linear; genomic DNA; STD; PRO; 10068 BP.
XX
AC   X52291;
XX
DT   28-APR-1990 (Rel. 24, Created)
DT   10-FEB-1999 (Rel. 58, Last updated, Version 11)
XX
DE   Rhodobacter capsulatus clustered genes crtA-F, I and K involved in
DE   carotenoid biosynthesis
XX
KW   crtA gene; crtB gene; crtC gene; crtD gene; crtE gene; crtF gene;
KW   crtI gene; crtK gene; crtK protein; hydroxyneurosporene methyltransferase;
KW   hydroxyneurosporene synthase; methoxyneurosporene dehydrogenase;
KW   photosynthesis; phytoene dehydrogenase; phytoene synthase;
KW   prephytoene pyrophosphate synthase; spheroidene monooxygenase.
XX
OS   Rhodobacter capsulatus
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
XX
RN   [1]
RP   1-10068
RA   Alberti M.;
RT   ;
RL   Submitted (24-MAR-1990) to the EMBL/GenBank/DDBJ databases.
RL   Alberti M., Lawrence Berkeley Laboratory, Division of Chemical Biodynamics,
RL   Bldg 3 Berkeley CA 94720, U S A.
XX
RN   [2]
RP   1-10068
RX   DOI; 10.1007/BF00334364
RX   PUBMED; 2747617.
RA   Armstrong G.A., Alberti M., Leach F., Hearst J.E.;
RT   "Nucleotide sequence, organization, and nature of the protein products of
RT   the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus";
RL   Mol. Gen. Genet. 216(2-3):254-268(1989).
XX
CC   Rhodobacter capsulatus is a pseudonym for Rhodopseudomonas
CC   capsulata
CC   Start codon for crtI [ref. 2] and crtF is GTG.
CC   *source: pFL104, pFL103, pGABX1, pGABX2
CC   Gene:   Product
CC   CrtA:   spheroidene monooxygenase
CC   CrtI:   phytoene dehydrogenase
CC   CrtB:   prephytoene pyrophosphate synthase
CC   CrtK:   crtK protein
CC   CrtC:   hydroxyneurosporene synthase
CC   CrtD:   methoxyneurosporene dehydrogenase
CC   CrtE:   phytoene synthase
CC   CrtF:   hydroxyneurosporene methyltransferase
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..10068
FT                   /organism="Rhodobacter capsulatus"
FT                   /strain="SB1003"
FT                   /mol_type="genomic DNA"
FT                   /clone="pRPS404, subclones: pFL227, pFL268"
FT                   /db_xref="taxon:1061"
FT   CDS             complement(2..1777)
FT                   /transl_table=11
FT                   /note="crtA gene product (AA 1-591)"
FT                   /db_xref="GOA:P17055"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17055"
FT                   /protein_id="CAA36532.1"
FT                   /translation="MPVASLSLFRFDGTSSLPWVISQMILSRRPLNDEPRVKFYKLCGS
FT                   GTGEGFTPKPNWRVWAIMAAFDTEADARDVTANHPVWKRWRAHAAETLVLHLQPLSARG
FT                   TWGGVNPFLPEQVAEPSPDEPVVALTRAAIKPHKANAFWSRVPKISEKVGEDQNLMFKI
FT                   GIGEIPLFHQVTFSIWPDVAKMNAFARGDTPHGKAIRAAREEGWFTEELYARFRLLGDR
FT                   GKLDGQGPARQQSLGKGNCMTTAVARLQPSASGAKTRPVFPFSAIVGQEDMKLALLLTA
FT                   VDPGIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMIPDWATVLSTNV
FT                   IRKPTPVVDLPLGVSEDRVVGALDIERAISKGEKAFEPGLLARANRGYLYIDECNLLED
FT                   HIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEGDLRPQLLDRFGLSVEVLS
FT                   PRDVETRVEVIRRRDTYDADPKAFLEEWRPKDMDIRNQILEARERLPKVEAPNTALYDC
FT                   AALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLRRDPLDEA
FT                   GSTARVARTVEETLP"
FT   misc_feature    complement(1794..1818)
FT                   /note="palindromic motif (pot. binding site for regulatory
FT                   protein)"
FT   misc_feature    1871..1895
FT                   /note="palindromic motif (pot. binding site for regulatory
FT                   protein)"
FT   promoter        1873..1900
FT                   /note="E. coli-like sigma-70 promoter"
FT   CDS             1935..3509
FT                   /transl_table=11
FT                   /note="crtI gene product (AA 1-524)"
FT                   /db_xref="GOA:P17054"
FT                   /db_xref="InterPro:IPR002937"
FT                   /db_xref="InterPro:IPR008150"
FT                   /db_xref="InterPro:IPR014105"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17054"
FT                   /protein_id="CAA36533.1"
FT                   /translation="MSKNTEGMGRAVVIGAGLGGLAAAMRLGAKGYKVTVVDRLDRPGG
FT                   RGSSITKGGHRFDLGPTIVTVPDRLRELWADCGRDFDKDVSLVPMEPFYTIDFPDGEKY
FT                   TAYGDDAKVKAEVARISPGDVEGFRHFMWDAKARYEFGYENLGRKPMSKLWDLIKVLPT
FT                   FGWLRADRSVYGHAKKMVKDDHLRFALSFHPLFIGGDPFHVTSMYILVSQLEKKFGVHY
FT                   AIGGVQAIADAMAKVITDQGGEMRLNTEVDEILVSRDGKATGIRLMDGTELPAQVVVSN
FT                   ADAGHTYKRLLRNRDRWRWTDEKLDKKRWSMGLFVWYFGTKGTAKMWKDVGHHTVVVGP
FT                   RYKEHVQDIFIKGELAEDMSLYVHRPSVTDPTAAPKGDDTFYVLSPVPNLGFDNGVDWS
FT                   VEAEKYKAKVLKVIEERLLPGVAEKITEEVVFTPETFRDRYLSPLGAGFSLEPRILQSA
FT                   WFRPHNASEEVDGLYLVGAGTHPGAGVPSVIGSGELVAQMIPDAPKPETPAAAAPKART
FT                   PRAKAAQ"
FT   conflict        2034..2036
FT                   /note="crtI GTG start in ref [2]"
FT                   /citation=[2]
FT   CDS             3506..4525
FT                   /transl_table=11
FT                   /note="crtB gene product (AA 1-339)"
FT                   /db_xref="GOA:P17056"
FT                   /db_xref="InterPro:IPR002060"
FT                   /db_xref="InterPro:IPR008949"
FT                   /db_xref="InterPro:IPR019845"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17056"
FT                   /protein_id="CAA36534.1"
FT                   /translation="MIAEADMEVCRELIRTGSYSFHAASRVLPARVRDPALALYAFCRV
FT                   ADDEVDEVGAPRDKAAAVLKLGDRLEDIYAGRPRNAPSDRAFAAVVEEFEMPRELPEAL
FT                   LEGFAWDAEGRWYHTLSDVQAYSARVAAAVGAMMCVLMRVRNPDALARACDLGLAMQMS
FT                   NIARDVGEDARAGRLFLPTDWMVEEGIDPQAFLADPQPTKGIRRVTERLLNRADRLYWR
FT                   AATGVRLLPFDCRPGIMAAGKIYAAIGAEVAKAKYDNITRRAHTTKGRKLWLVANSAMS
FT                   ATATSMLPLSPRVHAKPEPEVAHLVDAAAHRNLHPERSEVLISALMALKARDRGLAMD"
FT   terminator      3589..3623
FT                   /note="pot. rho-independent terminator"
FT   terminator      4505..4538
FT                   /note="pot. rho-independent terminator"
FT   CDS             4601..5083
FT                   /transl_table=11
FT                   /note="crtK gene product (AA 1-160)"
FT                   /db_xref="GOA:P17057"
FT                   /db_xref="InterPro:IPR004307"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17057"
FT                   /protein_id="CAA36535.1"
FT                   /translation="MSLTLFAVYFVACACAGATGAIFSPGAWYDSLKKPSWVPPNWLFP
FT                   VAWSTLYILMSISAARVSGLAMENELAVLGLAFWAVQIAVNTLWTPIFFGLHRLAGGML
FT                   VLVLLWLSVFATCVLFWSVDWLSGLMFVPYVIWVTVAGALNFSVWRLNPGEKPITL"
FT   terminator      5095..5135
FT                   /note="pot. rho-independent terminator"
FT   terminator      complement(5157..5225)
FT                   /note="pot. rho-independent terminator"
FT   CDS             complement(5318..6163)
FT                   /transl_table=11
FT                   /note="crtC gene product (AA 1-281)"
FT                   /db_xref="GOA:P17058"
FT                   /db_xref="InterPro:IPR010791"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17058"
FT                   /protein_id="CAA36536.1"
FT                   /translation="MIAFIGSVFSPWYRWSGRREPQNHCCINMVTTGTDGRFTMTDRGR
FT                   SALRQSRDSFQVGPSKLTWTGKELVIDVDEWGALPKLGKLKGRVVLTPRAVTGVEVRLT
FT                   PDAGHTWRPFAPIADVEVDLAPGHKWTGHGYFDANFGTRALEEDFSFWTWGRFPLKDRT
FT                   VCFYDATRLDRTKVALAVQINPDGSVCEIDSPPPLVKMKRTPWFVRRETRCDAGAHPAG
FT                   VYSLLEAPFYSRALMRTQIDGEETVGMHEALDLVRFRQPVLKPMLAVRVPRRAGWKHKD
FT                   "
FT   CDS             complement(6229..7713)
FT                   /transl_table=11
FT                   /note="crtD gene product (AA 1-494)"
FT                   /db_xref="GOA:P17059"
FT                   /db_xref="InterPro:IPR002937"
FT                   /db_xref="InterPro:IPR008150"
FT                   /db_xref="InterPro:IPR014105"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17059"
FT                   /protein_id="CAA36537.1"
FT                   /translation="MRSETDVVVIGARMGGLAAAIGAAAAGLRVTVVEAGDAPGGKARA
FT                   VPTPGGPADTGPTVLTMRHVLDALFAACGTRAEEHLTLIPLPRLARHFWPDGSSLDLFT
FT                   DTEANIEAIRAFAGDKEAAAFRRFDHLTTGLWEAFHRSVIAAPKPDLWRIAAATVTRPQ
FT                   LWPALRPGLTMRDLLAHHFKDPRLAQLFGRYATYVGGRPGATPAVLSLIWQAEVQGVWA
FT                   IREGMHGVAAALARVAEAKGVRFHYGAKAKRIVRKEGRVTAVEIETGVSIPCGACIFNG
FT                   DPGALRDGLLGDAARASMEKSPRPAPSLSAWVWAFGATPIGVDLAHHNVFFTADPELEF
FT                   GPIGAGEMPEEPTLYICAQDREMQAPVPEIERFEIIMNGPAGHQPFPQEEAQCRARTFP
FT                   MLAAMGLTFSPDPETRALTTPALLSRRFPGSLGAIYGGSPEGTLATFRRPLARTGLKGL
FT                   YLAGGGTHPGAGVPMALTSGTHAARALLADRISAAK"
FT   misc_feature    7778..7802
FT                   /note="palindromic motif (pot. binding site for regulatory
FT                   protein)"
FT   promoter        complement(7791..7818)
FT                   /note="E. coli-like sigma-70 promoter"
FT   CDS             7850..8719
FT                   /transl_table=11
FT                   /note="crtE gene product (AA 1-289)"
FT                   /db_xref="GOA:P17060"
FT                   /db_xref="InterPro:IPR000092"
FT                   /db_xref="InterPro:IPR008949"
FT                   /db_xref="InterPro:IPR017446"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17060"
FT                   /protein_id="CAA36538.1"
FT                   /translation="MSLDKRIESALVKALSPEALGESPPLLAAALPYGVFPGGARIRPT
FT                   ILVSVALACGDDCPAVTDAAAVALELMHCASLVHDDLPAFDNADIRRGKPSLHKAYNEP
FT                   LAVLAGDSLLIRGFEVLADVGAVNPDRALKLISKLGQLSGARGGICAGQAWESESKVDL
FT                   AAYHQAKTGALFIAATQMGAIAAGYEAEPWFDLGMRIGSAFQIADDLKDALMSAEAMGK
FT                   PAGQDIANERPNAVKTMGIEGARKHLQDVLAGAIASIPSCPGEAKLAQMVQLYAHKIMD
FT                   IPASAERG"
FT   CDS             8722..9903
FT                   /transl_table=11
FT                   /note="crtF gene product (AA 1-393)"
FT                   /db_xref="GOA:P17061"
FT                   /db_xref="InterPro:IPR001077"
FT                   /db_xref="InterPro:IPR016461"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17061"
FT                   /protein_id="CAA36539.1"
FT                   /translation="MPKDDHTGATADRTAQPTGTGKQPLVPGQPGAAPVQPGRVNFFTR
FT                   IALSQRLHEIFERLPLMNRVTRREGEALFDIVSGFVQSQVLLAIVEFRVLHILAGASWP
FT                   LPQLAERTGLAEDRLAVLMQAAAALKLVKFRRGLWQLAPRGAAFITVPGLEAMVRHHPV
FT                   LYRDLADPVAFLKGDIEPELAGFWPYVFGPLAQEDAGLAERYSQLMADSQRVVADDTLR
FT                   LVDLRDAKRVMDVGGGTGAFLRVVAKLYPELPLTLFDLPHVLSVADRFSPKLDFAPGSF
FT                   RDDPIPQGADVITLVRVLYDHPDSVVEPLLAKVHAALPPGGRLIISEAMAGGAKPDRAC
FT                   DVYFAFYTMAMSSGRTRSPEEIKQMLEKAGFTKVSKPRTLRPFITSVIEAERG"
FT   terminator      9885..9928
FT                   /note="pot. rho-independent terminator"
FT   promoter        9983..10011
FT                   /note="E. coli-like sigma-70 promoter"
FT   misc_feature    9994..10018
FT                   /note="palindromic motif (pot. binding site for regulatory
FT                   protein)"
FT   CDS             10066..>10068
FT                   /transl_table=11
FT                   /note="bchC gene product (ORFJ)"
FT                   /protein_id="CAA36540.1"
FT                   /translation="M"
XX
SQ   Sequence 10068 BP; 1676 A; 3292 C; 3350 G; 1750 T; 0 other;
     gttacggcaa cgtttcttcg accgtccggg ccacgcgggc cgtcgagccg gcttcatcaa        60
     ggggatcgcg gcgcagacgg tgcgacagcg ccatcgttgc cacccgcttc aggtgatcgc       120
     gaccgaccgc ggttgcccct tccagcgccg caagggcacg ggccgatcgc agaagcgtca       180
     gctcgccccg cagaccgtcg gaccccagcg cgatgcaaag cgcggcgcag tcataaagcg       240
     cggtgttcgg cgcctcgacc ttcggcagac gttcacgcgc ttccagaatc tggttgcgga       300
     tgtccatgtc cttgggccgc cattcttcca gaaaggcttt cggatctgcg tcataggtgt       360
     cgcggcgacg gatcacctcg acccgggttt cgacgtcgcg gggcgacaga acctcgaccg       420
     agaggccgaa acggtccaga agctgcggcc gcaggtcgcc ctcttccggg ttgcccgagc       480
     cgaccagaac gaaacgggcg gggtgacgga tcgagaggcc gtcgcgttcc accacgttct       540
     cgcccgattg cgccacgtcg agcagaagat cgacgatgtg atcttccagc aggttgcatt       600
     cgtcgatgta aaggtaaccg cggttggccc gggccagaag gcccggttca aacgcctttt       660
     cccctttcga gatcgcgcgc tcgatatcca gcgcccccac cacgcggtct tccgacacgc       720
     cgagcggcag atcgacgacc ggggtcggct tgcggatcac gttggtcgaa agcacggtcg       780
     cccaatcggg gatcatctcg acattgggcg aggacaccgg gcagccctcg accgcctcga       840
     tttcgggcaa aagcgccgcc agcgcccgca ccgcggtcga tttgccggtg ccgcggtcac       900
     caaagaccag aacgccgccg atgccgggat cgaccgcggt caacagcagc gccagtttca       960
     tgtcttcctg accgacgatg gcagaaaagg gaaagacggg tctcgtcttc gcgcccgaag      1020
     cagagggttg aagtcgagcg acggcggtag tcatgcagtt tccctttcca agactttgct      1080
     ggcgagcggg tccttgccca tccagcttcc ctcggtcccc aagcaaacgg aaccgggcat      1140
     agagttcttc ggtgaaccaa ccttcttcac gcgcagcacg gatggccttg ccatgcggcg      1200
     tgtcgccgcg ggcgaaggcg ttcatctttg ccacatccgg ccagatcgag aaagtcactt      1260
     gatggaaaag gggaatttcc ccgatcccga tcttgaacat caggttctga tcctcgccga      1320
     ctttctcgga aatcttcggc acgcgcgacc agaaggcatt ggccttgtgc ggcttgatcg      1380
     cggcgcgggt cagcgccacc acgggctcgt ccgggcttgg ctcggccacc tgttcgggca      1440
     ggaacggatt gacgccgccc caggtgccgc gcgccgaaag cggctgcaga tgcagcacca      1500
     gcgtttccgc cgcatgcgcc cgccagcgct tccagaccgg gtggttcgcg gtcacgtcgc      1560
     gggcatcggc ctcggtgtcg aaagccgcca tgatcgccca gacgcgccag ttcggcttcg      1620
     gcgtgaagcc ctcgccggtg cccgatccgc acagtttgta gaacttcacc cgcggctcgt      1680
     cgttcagggg gcggcgggac aggatcatct ggctgatgac ccagggcagc gagcttgtgc      1740
     cgtcgaaacg gaacaggctg agtgaggcga caggcatcta cgtcctcccc tgtgatgtgt      1800
     aacgggatat ttacatctgg gtcccttgta atggaaggcc tcagacgttt tgtcgcgaga      1860
     cagcgtcgac agttgtaaat cggaattgac gacctatcat ccccccaatg caacctgaaa      1920
     ctaccgaaga aaccatgtcc aagaacacag aaggtatggg tcgcgccgtt gtcatcggtg      1980
     ccggccttgg cggtcttgct gcagcgatgc ggctgggcgc aaaaggttac aaggtgacgg      2040
     tcgtcgatcg tctggatcgg cccggcgggc gtggctcttc gatcaccaag ggcgggcatc      2100
     gattcgacct tgggccgacg atcgtgacgg tgcccgaccg gctgcgcgag ctttgggccg      2160
     attgcgggcg cgatttcgac aaggacgtga gccttgtgcc gatggagccc ttctacacca      2220
     tcgatttccc cgatggcgag aaatacaccg cttacggcga tgacgccaag gtcaaggccg      2280
     aggtggcgcg gatcagcccc ggcgatgtcg agggcttccg ccatttcatg tgggacgcca      2340
     aggcccgtta tgaattcggc tatgaaaacc tcggccgcaa gccgatgagc aagctgtggg      2400
     acctgatcaa ggttctgccg actttcggct ggctgcgcgc cgaccgctcg gtctatggcc      2460
     atgccaagaa gatggtgaag gacgaccacc tgcgcttcgc gctgtcgttc catccgcttt      2520
     tcatcggcgg cgaccccttc catgtgacgt cgatgtatat cctcgtcagc cagctcgaaa      2580
     agaaattcgg cgtgcattac gcgatcggcg gcgtgcaggc gattgccgat gcgatggcca      2640
     aggtgatcac cgatcagggc ggcgagatgc gcctgaacac cgaggtcgac gagatcctgg      2700
     tctcgcgtga cggcaaggcc acgggcatcc ggctgatgga cggcaccgag cttccggcgc      2760
     aggttgtcgt ctcgaacgcc gatgcgggcc acacctacaa gcgtctcttg cgcaaccgcg      2820
     accgctggcg ctggaccgac gagaagctcg acaagaagcg ctggtcgatg gggcttttcg      2880
     tctggtattt cggcaccaag ggtacggcca agatgtggaa ggatgtgggt caccacaccg      2940
     tcgtcgtcgg gccgcgctac aaggaacatg tgcaggacat cttcatcaag ggcgagctgg      3000
     ccgaggacat gagcctttat gtccaccgtc cctcggtcac tgatccgacc gcggcgccga      3060
     aaggcgacga caccttctac gtgctttcgc cggtgccgaa cctcggcttc gacaatggcg      3120
     tggactggtc ggtcgaggcc gagaaataca aggccaaggt gctgaaagtg atcgaggaac      3180
     ggctgcttcc gggggttgcc gaaaagatca ccgaggaagt ggtcttcacg ccggaaacct      3240
     tccgcgaccg ttatctctcg ccgctgggcg cgggcttctc gctggaaccg cggatcctgc      3300
     aatcggcctg gttccgcccg cataacgcct cggaagaggt ggacgggctt tatctggtcg      3360
     gcgcgggcac ccatccgggc gccggtgtgc cctcggtgat cggctcgggc gagcttgtcg      3420
     cgcagatgat cccggatgcg ccgaagcccg agacccccgc ggcggctgcg cccaaggccc      3480
     ggacgccccg ggccaaggcg gcgcaatgat cgccgaagcg gatatggagg tctgccggga      3540
     gctgatccgc accggcagct actccttcca tgcggcgtcc agagttctgc cggcgcgggt      3600
     ccgtgacccc gcgctggcgc tttacgcctt ttgccgcgtc gccgatgacg aagtcgacga      3660
     ggttggcgcg ccgcgcgaca aggctgcggc ggttttgaaa cttggcgacc ggctggagga      3720
     catctatgcc ggtcgtccgc gcaatgcgcc ctcggatcgg gctttcgcgg cggtggtcga      3780
     ggaattcgag atgccgcgcg aattgcccga ggcgctgctg gagggcttcg cctgggatgc      3840
     cgaggggcgg tggtatcaca cgctttcgga cgtgcaggcc tattcggcgc gggtggcggc      3900
     cgccgtcggc gcgatgatgt gcgtgctgat gcgggtgcgc aaccccgatg cgctggcgcg      3960
     ggcctgcgat ctcggtcttg ccatgcagat gtcgaacatc gcccgcgacg tgggcgagga      4020
     tgcccgggcg gggcggcttt tcctgccgac cgactggatg gtcgaggagg ggatcgatcc      4080
     gcaggcgttc ctggccgatc cgcagcccac caagggcatc cgccgggtca ccgagcggtt      4140
     gctgaaccgc gccgaccggc tttactggcg ggcggcgacg ggggtgcggc ttttgccctt      4200
     tgactgccga ccggggatca tggccgcggg caagatctat gccgcgatcg gggccgaggt      4260
     ggcgaaggcg aaatacgaca acatcacccg gcgtgcccac acgaccaagg gccgcaagct      4320
     gtggctggtg gcgaattccg cgatgtcggc gacggcgacc tcgatgctgc cgctctcgcc      4380
     gcgggtgcat gccaagcccg agcccgaagt ggcgcatctg gtcgatgccg ccgcgcatcg      4440
     caacctgcat cccgaacggt ccgaggtgct gatctcggcg ctgatggcgc tgaaggcgcg      4500
     cgaccgcggc ctggcgatgg attgaggccg cgacggttcg tcactggacg tgcgcgcgcc      4560
     ccgggtccac aacggggcgt gtccacaacc ggaggccatg atgagcctga ctctctttgc      4620
     cgtctatttc gtcgcctgcg cctgcgcggg cgcgaccgga gcgatcttca gccccggcgc      4680
     atggtatgac agcctgaaga aaccgagctg ggtgccgccg aactggctgt ttcccgtcgc      4740
     ctggtccacg ctttacatcc tgatgtcgat ttcggcggcg cgggtatccg ggctggcgat      4800
     ggaaaacgaa ctggccgtgc tgggtctggc cttctgggcg gtgcagatcg cggtcaacac      4860
     gctttggacg ccgatcttct tcggcctgca ccggctggcg ggcgggatgc tggttctggt      4920
     gcttttgtgg ctgagcgtct ttgccacctg cgtcctgttc tggagcgtcg actggctctc      4980
     ggggctgatg ttcgtgccct atgtgatctg ggtgacggtg gccggggcgc tgaatttcag      5040
     cgtctggcgg ctcaatccgg gcgaaaagcc gatcacgctt tgatctgctg atcctggtgt      5100
     gaccgaggcc atcgcctcgg tcatgcgcaa cctttccccg gggccgccga gggcccaaag      5160
     gcactcggcc agcgcccgcc ccgcccatgg cgggcgcttc tcgcccgccg ggacgggcgc      5220
     tggcctctgt tgtgcttggg gaggcggtct tgcggatgcg tcgcgcggcg ggcggggaaa      5280
     agcggtgctt ttcctgatcc gcccgaaacg gacgatttca gtccttgtgc ttccacccgg      5340
     cccggcgcgg cacccgcacg gccagcatcg gcttcagcac cggctggcgg aaccgcacca      5400
     gatcgagcgc ctcgtgcatg cccaccgttt cctcgccgtc gatctgcgtg cgcatcagcg      5460
     cgcgggaata gaagggcgcc tccagcagcg aatagacccc ggccggatgc gcccccgcat      5520
     cgcagcgcgt ttcacgccgc acgaaccagg gcgtgcgctt catcttcacc aggggcggag      5580
     ggctgtcgat ctcgcagacc gacccgtccg ggttgatctg cacggcgagc gccaccttgg      5640
     tccggtccaa ccgcgtcgca tcgtaaaaac agaccgttcg atccttcagc gggaaccgcc      5700
     cccaggtcca gaacgagaag tcttcctcca gcgcgcgggt gccgaaattg gcgtcgaaat      5760
     agccgtgtcc ggtccatttg tgcccgggcg ccagatcgac ctcgacatcg gcgatgggcg      5820
     cgaaaggccg ccaggtgtgg cccgcatccg gcgtcagccg cacctcgacc ccggtcaccg      5880
     cgcgcggcgt cagcacgacc cggcccttga gcttgcccag cttcggcaaa gccccccatt      5940
     cgtcaacgtc gatcaccagc tccttgccgg tccaggtcag cttcgacggc ccgacctgaa      6000
     agctgtcgcg cgactgccgc agcgcagacc ggccccggtc ggtcatcgtg aagcgcccat      6060
     cagtgccggt cgtcaccatg ttgatgcagc agtgattttg cggctcgcga cgacccgacc      6120
     agcgatacca cgggctgaag accgagccga tgaaggcgat catcgagaag gccttttcgc      6180
     cgtcgtcgga gatgccgtcg caataccacc aggcgtagcc gttcggccct acttcgcggc      6240
     ggaaatccgg tccgccagca aggcccgtgc tgcatgcgtc ccggaagtca gcgccatggg      6300
     caccccggca cccgggtgcg ttcccccacc cgccagataa agccccttga gccccgtccg      6360
     cgccagaggc cgccggaagg tcgccagcgt cccctccggc gagccgccgt agatcgcccc      6420
     cagcgagccc gggaaccgcc gcgacagcag cgccggcgtc gtcagcgccc gggtttccgg      6480
     gtccgggctg aaggtcagtc ccatcgcggc gagcatcggg aaggtgcgtg ccctgcattg      6540
     tgcctcctcc tgaggaaagg gttgatggcc tgccgggccg ttcatgatga tttcaaagcg      6600
     ttcgatttcc ggcaccgggg cctgcatctc gcggtcctgc gcacagatgt aaagcgtcgg      6660
     ttcctcgggc atctcgcccg cgccgatggg cccgaattcc agctccggat cggcggtgaa      6720
     gaagacgttg tgatgcgcga ggtcaacgcc gatcggggtg gcgccaaagg cccagaccca      6780
     ggcggaaaga ctgggggcgg ggcggggcga tttctccatc gaggcgcggg cggcatcgcc      6840
     cagaagcccg tcgcgcaacg cccccggatc gccgttgaag atgcaggcgc cgcaggggat      6900
     cgagacgccg gtctcgatct cgaccgcggt gacccggcct tccttgcgca cgatgcgctt      6960
     ggccttggcg ccgtaatgga accgcacgcc cttcgcctcg gccacccggg ccagcgcggc      7020
     ggcaacgcca tgcatcccct cgcggatcgc ccagacgccc tgaacctcgg cctgccagat      7080
     cagcgagagc accgcgggcg tcgcccccgg acggccgccg acataggtcg catagcggcc      7140
     gaagagctgc gccagccgcg gatccttgaa gtgatgggcg agcaggtcgc gcatcgtcag      7200
     cccggggcgc agcgcgggcc aaagctgcgg ccgcgtcacc gtggccgcgg cgattcgcca      7260
     aagatccggc ttcggcgccg cgatcaccga gcggtggaac gcctcccaca gccccgtcgt      7320
     caggtgatcg aagcggcgga atgccgcagc ttccttgtcg cccgcaaagg cccggatcgc      7380
     ctcgatattg gcttcggtgt cggtgaacag atcgaggctg gagccgtcgg gccagaaatg      7440
     ccgggcgagt cggggcaggg ggatcagcgt cagatgttcc tcggcccggg tgccgcaggc      7500
     ggcaaagagc gcgtccagaa catgccgcat cgtcaagacc gtgggccccg tatccgcagg      7560
     cccgccgggg gtcggaaccg cccgcgcctt gccgcccggg gcatcgcccg cctcaaccac      7620
     cgtgacccga aggcccgccg ccgccgcacc gatggcggcc gcaaggcccc ccattctggc      7680
     gccgatcacc acgacgtccg tttcactccg catcgctcgc tcccgcacgc accgccgtcc      7740
     gcaccccccc gggagtgcaa ttttgtccca tattcttggg tgtaagtttc agtttacaca      7800
     ggtaggtgcg aatgccaatg tgcgtcgtga cgcagcggag ggctctgtca tgtctctgga      7860
     taaacgtatc gagtcggcgc tggtcaaggc gctgtcaccc gaggctttgg gtgaatctcc      7920
     gccgttgctt gccgccgcgc tgccttacgg ggtgtttccc ggcggcgcgc ggatccggcc      7980
     gacgatcctt gtctcggtcg cgctcgcctg tggcgacgat tgcccggcgg tcaccgatgc      8040
     cgcggccgtg gcgctggagc tgatgcattg cgcgagcctc gtgcatgacg atctgcccgc      8100
     cttcgacaat gccgacatcc ggcgcggcaa gccgagcctt cacaaggcct ataatgaacc      8160
     gcttgcggtt ctggcgggcg acagcctgct gatccgcggc ttcgaagtgc tggccgatgt      8220
     cggcgccgtc aacccggacc gggcgctgaa gctgatctcg aaactgggtc agctgtcggg      8280
     ggcgcgcggc gggatctgcg ccggtcaggc ctgggaaagc gaatccaagg tcgatctggc      8340
     cgcctatcat caggcgaaga ccggggcgct gttcattgcc gcgacccaga tgggggcgat      8400
     tgcggcgggc tacgaggccg aaccctggtt cgatctgggc atgcggatcg gctcggcctt      8460
     ccagatcgcc gacgacctga aagacgcgct gatgtcggcc gaggcaatgg gcaagcccgc      8520
     cgggcaggac atcgcgaacg aacgcccgaa tgcggtcaag acgatgggca tcgagggcgc      8580
     gcgcaaacat ctgcaagatg tgctggcggg ggcgatcgcc tcgatcccgt cctgccccgg      8640
     tgaggcgaag ctggcccaga tggtgcagct ttacgcccac aagatcatgg acatcccggc      8700
     cagcgccgag aggggctgat cgtgccgaag gacgaccaca cgggcgcgac ggccgaccgg      8760
     accgcgcagc cgacaggaac gggaaagcag ccgctggttc cgggccagcc cggggcggcg      8820
     ccggtgcagc cggggcgggt gaatttcttc acccggatcg cgctgtcgca acggctgcat      8880
     gaaatcttcg aacgcctgcc gctgatgaac cgcgtcaccc ggcgcgaggg cgaggcgctc      8940
     ttcgacatcg tttcgggctt cgtgcaaagc caggttctct tggcgatcgt cgaattccgg      9000
     gtgctgcata ttctggccgg ggcctcttgg cccttgccgc aactggccga acgcaccggc      9060
     ctggccgagg accggctggc ggtgctgatg caggccgccg ccgccttgaa gctggtgaaa      9120
     ttccgccgcg gtctgtggca gcttgccccg cgtggcgccg ccttcatcac cgtgccaggg      9180
     ctcgaggcga tggtgcgcca tcaccccgtc ctttaccgcg atctggccga tccggtggct      9240
     tttctgaaag gcgacatcga acccgagctg gcgggcttct ggccctatgt cttcgggccg      9300
     ctggcgcagg aagatgcggg gctcgccgag cgctattcgc agctgatggc cgacagccag      9360
     cgcgtcgtgg ccgatgacac cttgcggctt gtcgatctgc gcgatgccaa gcgggtgatg      9420
     gatgtgggcg gcggcaccgg ggccttcctg cgcgtcgtgg ccaagcttta ccccgagctg      9480
     cccttgacgc tgttcgacct gccgcatgtg ctgtcggtgg cggaccgctt cagcccgaag      9540
     ctcgatttcg cgccgggcag cttccgcgac gatccgatcc cgcagggcgc cgatgtcatc      9600
     actttggtgc gcgtgctgta tgaccatcct gacagcgtcg tcgaaccgct tctggccaag      9660
     gtgcatgccg ccttgccgcc gggcgggcgt ctgatcatct cggaggcgat ggcggggggc      9720
     gcaaaacccg accgtgcctg cgatgtctat ttcgccttct acacgatggc gatgagttcg      9780
     gggcgcacgc gttcccccga agagatcaag caaatgcttg aaaaagctgg gttcaccaag      9840
     gtgtcgaaac cgcggaccct gcgccccttc atcacctcgg tgatcgaggc cgaacgcggc      9900
     tgacacggct gcgttcggac ccggctttga cccgggggtc agaaagtcgc acatccgtct      9960
     gtcgcaaaag tgtctaatca aattgacagt cgggcgtgta agttcaatga tacacacagg     10020
     cgtgatcagc ccgactctcc ggcccgatca taccgggagc aagaaatg                  10068
//


  
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