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EBI DbfetchID X51735; SV 1; linear; genomic DNA; STD; INV; 1996 BP. XX AC X51735; XX DT 19-MAR-1990 (Rel. 23, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 3) XX DE Leishmania amazonensis dihydrofolate reductase thymidylate synthase gene DE (EC 1.5.1.3 and 2.1.1.45) XX KW dihydrofolate reductase thymidylate synthase. XX OS Leishmania amazonensis OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania. XX RN [1] RP 1-1996 RA Beverley S.M.; RT ; RL Submitted (16-FEB-1990) to the EMBL/GenBank/DDBJ databases. RL Beverley S.M., Harvard Medical School, Dept of Biol. Chem & Molec. Pharm., RL 250 Longwood Ave, Boston MA 02115, USA. XX RN [2] RP 1-1996 RX DOI; 10.1093/nar/18.9.2819 RX PUBMED; 2339068. RA Nelson K., Alonso G., Langer P.J., Beverley S.M.; RT "Sequence of the dihydrofolate reductase-thymidylate synthase (DHFR-TS) RT gene of Leishmania amazonensis"; RL Nucleic Acids Res. 18(9):2819-2819(1990). XX FH Key Location/Qualifiers FH FT source 1..1996 FT /organism="Leishmania amazonensis" FT /strain="LTB0016" FT /mol_type="genomic DNA" FT /dev_stage="promastigote" FT /db_xref="taxon:5659" FT CDS 255..1817 FT /note="dihydrofolate reductase thymidylate synthase (AA FT 1-520)" FT /db_xref="GOA:P16126" FT /db_xref="InterPro:IPR000398" FT /db_xref="InterPro:IPR001796" FT /db_xref="InterPro:IPR012262" FT /db_xref="InterPro:IPR017925" FT /db_xref="UniProtKB/Swiss-Prot:P16126" FT /protein_id="CAA36020.1" FT /translation="MSRAAAKFKIPMPVTKADFAFPSLRAFSIVVALDKQHGIGDGESI FT PWRVPEDMAFFKDQTTLLRNKKPPTDKKRNAVVMGRKTWESVPVKFRPLKGRLNVVLSS FT KATVEELLAPLPEEKRAAAAQDIVVVNGGLAAAVRLLARPPYCSSIETAYCVGGAQVYA FT DAMLSPCVEKLQEVYLTRIHTTAPACTRFFPFPPENAATAWDLASSQGRRKSAVDGLEF FT EICKYVPRNHEERQYLELIDRIMKTGIAKEDRTGVGTLSLFGAQMRFSLRDNRLPLLTT FT KRVFWRGVCEELLWFLRGETNAQLLADKDIHIWDGNGSREFLDSRGLTENTEMDLGPVY FT GFQWRHFGAEYRGLEANYDGEGVDQIKFIVETIKANPNDRRLLFTAWNPCALHKMALPP FT CHLLAQFYVNTEKSELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHT FT LGDAHVYRSHIDALKAQLERVPHAFPTLVFKEERQFLEDYELMDMEVIDYVPHPPIKME FT MAV" XX SQ Sequence 1996 BP; 383 A; 643 C; 623 G; 347 T; 0 other; gcatgcttga ggcgtacgtg aagagctcaa agacctctct cgtcctccct cctcacacca 60 tatcactgac attcatagag acccgtgcag cgagacgcgc tctggtcgtg cgcatcatcg 120 acacagcact ggggaacgaa actcacacac aaggtacgcg gcttccctca acctgttata 180 catagctgaa gagcagccct cctccatcat cctccatcat cgttcatcat cctcccggtc 240 cgcacaccac gacgatgtcc agggcggctg cgaagttcaa gattccgatg ccggtgacga 300 aggcggactt cgccttcccc tccctgcgcg ccttctccat cgtcgtggcc ctcgataagc 360 agcacggcat cggcgacggc gagtcgatcc cgtggcgggt gccggaggac atggcgttct 420 tcaaggacca gacgacgctg ctgcgcaaca agaagccgcc gacggacaag aagcgcaacg 480 ccgtcgtgat ggggcgcaag acgtgggaga gcgttccggt aaagttccgg ccactcaagg 540 gccggctgaa cgttgtgttg tcctcgaagg ccaccgtcga ggagcttctg gcgccactgc 600 cggaggaaaa gcgcgcggcg gcggcgcagg acattgtggt ggtgaacggc ggtctggccg 660 cggccgtccg cctcctcgca cgtccgccgt actgcagctc catcgagacg gcgtactgcg 720 tcggcggtgc gcaggtgtat gcggacgcca tgctgtcgcc atgcgtcgag aagctgcagg 780 aggtgtacct gacccgcatc cacacgacgg cgcctgcgtg cacgcgcttc ttcccgtttc 840 ctcccgagaa cgccgccacg gcgtgggacc tggcgtcgtc tcagggacgc cgcaagagcg 900 cggtggacgg cctcgagttc gagatttgca agtacgtgcc gcgcaaccac gaggagcggc 960 agtaccttga gctgattgac cgcatcatga agacggggat cgcgaaggag gaccgcaccg 1020 gcgtgggcac cttgagcctc ttcggcgcac agatgcggtt ctccctacgc gacaaccgcc 1080 tgccactgct gacgacgaag cgcgtcttct ggcgaggcgt gtgcgaggag ttgctgtggt 1140 tcctgcgcgg ggagacaaac gcgcagctgc tcgcggacaa ggacatacac atctgggacg 1200 gcaacggctc gcgcgagttt ctcgacagcc gcggcttgac agagaatacg gagatggacc 1260 tcggccctgt ctacggcttc cagtggcgcc acttcggggc agaataccgg gggctcgaag 1320 cgaactacga cggcgagggg gtggaccaga tcaagttcat cgtggagacg atcaaggcga 1380 acccgaacga ccgccgtctc ctgttcactg cgtggaaccc gtgcgcgctg cacaagatgg 1440 cactgccgcc gtgccacttg ctcgctcaat tctacgtgaa cacggagaag agcgagctat 1500 cctgcatgct gtaccaacgt tcgtgcgaca tgggcctcgg cgtccccttc aacatcgcct 1560 cctacgcgct gctcaccatc ctcattgcca aggcgacggg tctgcggcct ggtgagcttg 1620 tgcacaccct cggcgacgcc cacgtctacc gcagccacat cgatgccctc aaggcgcagc 1680 tcgagcgagt cccgcacgcg ttcccgaccc tcgtgttcaa ggaggagcgg cagttcctcg 1740 aggactacga gttgatggac atggaggtga tcgactacgt gccgcacccg ccgatcaaga 1800 tggagatggc cgtatagaga gagagatcga ggggaggggg acgccatgtg cgtcgtatgc 1860 atgcagccac cgccatgatg ctgctactca cctggccccc gcctcctcgt cgtacgacga 1920 ccgtcccttg cgcaaactca ttgggtaacc gtgagtggcg cggaggggtg cgcgcctgcg 1980 ttctcacgca cgtggc 1996 // |
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