EBI Dbfetch
ID X14603; SV 1; linear; genomic DNA; STD; FUN; 18120 BP.
XX
AC X14603;
XX
DT 23-NOV-1989 (Rel. 21, Created)
DT 14-NOV-2006 (Rel. 89, Last updated, Version 7)
XX
DE Neurospora crassa qa gene cluster
XX
KW 3-dehydroquinate dehydratase; dehydroquinase; Qa region; qa-1F gene;
KW qa-1S gene; qa-2 gene; qa-3 gene; qa-4 gene; qa-x gene; qa-y gene;
KW quinate dehydrogenase; quinate transporter; regulatory protein;
KW unidentified reading frame.
XX
OS Neurospora crassa
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
XX
RN [1]
RP 1-18120
RA Geever R.F.;
RT ;
RL Submitted (07-MAR-1989) to the EMBL/GenBank/DDBJ databases.
RL Geever R.F., University of Georgia, Department of Genetics, Athens GA
RL 30602, U S A.
XX
RN [2]
RP 1-18120
RX DOI; 10.1016/0022-2836(89)90438-5
RX PUBMED; 2525625.
RA Geever R.F., Huiet L., Baum J.A., Tyler B.M., Patel V.B., Rutledge B.J.,
RA Case M.E., Giles N.H.;
RT "DNA sequence, organization and regulation of the qa gene cluster of
RT Neurospora crassa";
RL J. Mol. Biol. 207(1):15-34(1989).
XX
DR TRANSFAC; R01290; NEUCR$QA2Q_01.
DR TRANSFAC; R01291; NEUCR$QA2_01.
DR TRANSFAC; R01292; NEUCR$QA2_02.
DR TRANSFAC; R01295; NEUCR$QA3_01.
DR TRANSFAC; R01296; NEUCR$QA3_02.
DR TRANSFAC; R01297; NEUCR$QA3_03.
DR TRANSFAC; R01298; NEUCR$QAY_01.
DR TRANSFAC; R01299; NEUCR$QAY_02.
DR TRANSFAC; R01300; NEUCR$QAY_03.
DR TRANSFAC; R01302; NEUCR$QA1F_01.
DR TRANSFAC; R01303; NEUCR$QA1F_02.
DR TRANSFAC; T00709; T00709.
XX
CC The sequence overlaps with that reported by
CC Ruthledge B.J. in Gene 32: 275-287(1984) ,
CC Huiet et. al. in Proc. Natl. Acad. Sci. USA 83:3381-3385(1986),
CC Alton et. al. in Proc. Natl. Acad. Sci. USA 79:1955-1959(1982)
CC ,
CC Geever et al. in Proc. Natl. Sci. USA 80:7298-7302 (1983)
CC .
CC
CC Data kindly reviewed (05-SEP-1989) by Geever R. F.
XX
FH Key Location/Qualifiers
FH
FT source 1..18120
FT /organism="Neurospora crassa"
FT /strain="74-OR23-1A"
FT /mol_type="genomic DNA"
FT /clone="pMSK335"
FT /db_xref="taxon:5141"
FT exon complement(504..744)
FT /gene="qa-x"
FT /number=3
FT intron complement(745..818)
FT /gene="qa-x"
FT /number=2
FT /experiment="experimental evidence, no additional details
FT recorded"
FT exon complement(819..890)
FT /gene="qa-x"
FT /number=2
FT intron complement(891..959)
FT /gene="qa-x"
FT /number=1
FT /experiment="experimental evidence, no additional details
FT recorded"
FT CDS complement(join(504..744,819..890,960..1669))
FT /gene="qa-x"
FT /db_xref="GOA:P11634"
FT /db_xref="InterPro:IPR000760"
FT /db_xref="InterPro:IPR020550"
FT /db_xref="InterPro:IPR020583"
FT /db_xref="UniProtKB/Swiss-Prot:P11634"
FT /protein_id="CAA32748.1"
FT /translation="MTSRTTTATELDEIYTFAVQLGKDAGNLLMEAARLRFSNNNANHD
FT KESTTQEFTEKDSAVDIVTQTDEDVEAFIKSAINTRYPSHDFIGEETYAKSSQSTRPYL
FT VTHTTPTWVVDPLDGTVNYTHLFPMFCVSIAFLVDGTPVIGVICAPMLGQLFTACKGRG
FT AWLNETQRLPLVRQPMPKSAPGGCVFSCEWGKDRKDRPEGNLYRKVESFVNMAAEVGGR
FT GGKGGMVHGVRSLGSATLDLAYTAMGSFDIWWEGGCWEWDVAAGIAILQEAGGLITSAN
FT PPEDWATAEIPDVKLGSRLYLVVRPAGPSEGETAREGQERTIREVWRRVRALDYTRPGA
FT "
FT exon complement(960..1669)
FT /gene="qa-x"
FT /number=1
FT CDS 2863..3384
FT /gene="qa-2"
FT /product="3-dehydroquinate dehydratase"
FT /EC_number="4.2.1.10"
FT /db_xref="GOA:P05195"
FT /db_xref="InterPro:IPR001874"
FT /db_xref="InterPro:IPR018509"
FT /db_xref="UniProtKB/Swiss-Prot:P05195"
FT /protein_id="CAA32749.1"
FT /translation="MASPRHILLINGPNLNLLGTREPQIYGSTTLHDIEQASQTLASSL
FT GLRLTTFQSNHEGAIIDRIHQAAGFVPSPPSPSPSSAATTTEAGLGPGDKVSAIIINPG
FT AYTHTSIGIRDALLGTGIPFVEVHVSNVHAREAFRHHSYLSDKAVAVICGLGPFGYSAA
FT LDFLGRHMKF"
FT CDS complement(3938..5017)
FT /gene="qa-4"
FT /product="DHS dehydratase"
FT /db_xref="GOA:P07046"
FT /db_xref="InterPro:IPR012307"
FT /db_xref="InterPro:IPR013022"
FT /db_xref="UniProtKB/Swiss-Prot:P07046"
FT /protein_id="CAA32750.1"
FT /translation="MPSKLAISSMSLGRCFAGHSLDSKLDAAQRYGYLGIELFYEDLVD
FT VAEHLSNERPSPEGPFVEAQIAAARHILQMCQARGLEVVCLQPFMHYDGLNDRAEHERR
FT LEKLALWIELAHELHTDIIQIPANFLPANQVSDNLDLIVSDLCKVADIGAQALPPIRFA
FT YESLCWSTRVDLWERCWDIVQRVDRPNFGICLDTFNILGRIYADPTSPSGRTPNAKEAV
FT RKSIANLVSRVDVSKVFYVQVVDAERLSKPLLPGHPYYNPEQPARMSWSRNCRLFYGET
FT EYGAYLPVKEVARALFHGIGFEGWVSLELFNRRMSEEGPEVPEELAMRGAISWAKLVQD
FT LRIPVEGPLVTMPRVSASL"
FT CDS 6965..7930
FT /gene="qa-3"
FT /product="quinate 5-dehydrogenase"
FT /EC_number="1.1.1.24"
FT /db_xref="GOA:P11635"
FT /db_xref="InterPro:IPR006151"
FT /db_xref="InterPro:IPR013708"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/Swiss-Prot:P11635"
FT /protein_id="CAA32751.1"
FT /translation="MSTATTTTSATTTMSVVQPRQQELLHLTSTPDITPYTRHGYLFGQ
FT KLAASMSPLLHSIVYSHLSLNWAQLRLDSPSIPLFLQLAQHPDFYGASVTMPHKVAIIP
FT HLDHLTPECRDVGACNTLFLKTDPATGRRLYCGANTDVIGVRESFVQNVSDPARVYESR
FT PALVIGGGGAARSAVYALHKWLGATDIYLVNRDKSEVDAVIAECTERGYGDRLVHVASV
FT EQAEGLEGPGAIVACIPDFPPKTEKEMLVRRIVETFLMKEEKGAMLEMCYNPSPFTELG
FT ALAEHEGWQVILGTEALIWQGIEQVCIRPELTLYCGGQLN"
FT CDS complement(8617..10230)
FT /gene="qa-y"
FT /product="quinate transporter"
FT /db_xref="GOA:P11636"
FT /db_xref="InterPro:IPR003663"
FT /db_xref="InterPro:IPR005828"
FT /db_xref="InterPro:IPR005829"
FT /db_xref="InterPro:IPR016196"
FT /db_xref="UniProtKB/Swiss-Prot:P11636"
FT /protein_id="CAA32752.1"
FT /translation="MTLLALKEDRPTPKAVYNWRVYTCAAIASFASCMIGYDSAFIGTT
FT LALPSFTKEFDFASYTPGALALLQSNIVSVYQAGAFFGCLFAYATSYFLGRRKSLIAFS
FT VVFIIGAAIMLAADGQGRGIDPIIAGRVLAGIGVGGASNMVPIYISELAPPAVRGRLVG
FT IYELGWQIGGLVGFWINYGVNTTMAPTRSQWLIPFAVQLIPAGLLFLGSFWIPESPRWL
FT YANGKREEAMKVLCWIRNLEPTDRYIVQEVSFIDADLERYTRQVGNGFWKPFLSLKQRK
FT VQWRFFLGGMLFFWQNGSGINAINYYSPTVFRSIGITGTDTGFLTTGIFGVVKMVLTII
FT WLLWLVDLVGRRRILFIGAAGGSLCMWFIGAYIKIADPGSNKAEDAKLTSGGIAAIFFF
FT YLWTAFYTPSWNGTPWVINSEMFDQNTRSLGQASAAANNWFWNFIISRFTPQMFIKMEY
FT GVYFFFASLMLLSIVFIYFFLPVTKSIPLEAMDRLFEIKPVQNANKNLMAELNFDRNPE
FT REESSSLDDKDRVTQTENAV"
FT exon complement(11384..13914)
FT /gene="qa-1S"
FT /number=2
FT intron complement(13915..13980)
FT /gene="qa-1S"
FT /number=1
FT /experiment="experimental evidence, no additional details
FT recorded"
FT CDS complement(join(11384..13914,13981..14206))
FT /gene="qa-1S"
FT /product="repressor"
FT /db_xref="GOA:P11637"
FT /db_xref="InterPro:IPR000623"
FT /db_xref="InterPro:IPR001381"
FT /db_xref="InterPro:IPR006151"
FT /db_xref="InterPro:IPR013708"
FT /db_xref="InterPro:IPR016040"
FT /db_xref="UniProtKB/Swiss-Prot:P11637"
FT /protein_id="CAA32753.1"
FT /translation="MNTIPARHVGDVAARDPLPLPHISSSVASGMKRSFATMAMLYNDT
FT GNSNDVGAHARRPPRTLSNSRSTSAHRVPLGSWSAPNSPPRRALPHHPITASFDPDASI
FT VIAGIRGAGKSTLAIMASTAMKRKIVDLESEFHHLTGLSSSSYKKTHGPVDYGRRQIAI
FT LQNILNLHRTRAILVCSWLERDVQAMLQDFSVSNPVIYVLRDAKAIEAHLKGYDKSKVG
FT TLLDATSTVLRRCTRFEFFNVSEENLDTHSASTSPPAVPDQRHTAPYLTLKRAERHFLK
FT FLSLILPKGTIPFVESAFPLASVPVEQRRFTYALALPVSALLDKGVDIQELDVGVDAIE
FT IIVDDLATSESGPTSPLGLAPHRASEISRVVGEIRRDTVIPIILHVVFPERALYEEALL
FT ALYMTYLNHALRLAPDYLTVDLGLDSGLLGQLTTVQGTTKVIGNKQLAEVNSPRWGDPS
FT WLQAYEKAQNTGCDLVRLTRPASNPRDNTDIRQFHVAVEAVGGPRLPFIAYNTGRLGRT
FT SMCFNEILTPVTPVPTKEDAIGLRNPAHRYLQPPLTALEATQALYSAFVHDPMKLYVFG
FT ANVGYSLSPAMHNAALKACGIPHHYKPLSTANIGTLREVISDPQFAGASVGLPFKVEII
FT SLTHSLSRHAKAIGAVNTLIPVRHLTADGGIPDEVSMFNNISQAGAVRALYGENTDWIG
FT IRACLRRGLSPANAVRSTSTGLVIGAGGMARAAVYAMLQLGVKKILIFNRTFANAEKLV
FT LHFENLLVRDALPLLSTGPRSHDNTCFHIIRSRDDPLPENFKNPTMIVSCIPTHTVDNT
FT PDPEFTVPLHWLDNPTGGIVLELDYKCLTSPLLEQTRREAHRGWVAMDGLDLLPEQGFA
FT QFELFTGRRAPRRLMRREVLRAYPDDQAKSHTAQLQPRLNGIATQIS"
FT exon complement(13981..14206)
FT /gene="qa-1S"
FT /number=1
FT CDS 15315..17765
FT /gene="qa-1F"
FT /product="activator"
FT /db_xref="GOA:P11638"
FT /db_xref="InterPro:IPR001138"
FT /db_xref="InterPro:IPR007219"
FT /db_xref="UniProtKB/Swiss-Prot:P11638"
FT /protein_id="CAA32754.1"
FT /translation="MPPKRKTLNAAAEANAHADGHADGNADGHVANTAASSNNARFADL
FT TNIDTPGLGPTTTTLLVEPARSKRQRVSRACDQCRAAREKCDGIQPACFPCVSQGRSCT
FT YQASPKKRGVQTGYIRTLELALAWMFENVARSEDALHNLLVRDAGQGSALLVGKDSPAA
FT ERLHARWATSRVNKSITRLLSGQAAQDPSEDGQSPSEDINVQDAGAKTSDFPHAPHLTF
FT SAPKSSTAETRTLPGPVRPPISANTLENNLQPDGTGIGKLPPNHWRLLDIYFSYTHSWL
FT PILEKKDMYQALYQYSEQGSLLPSANVESGVHAELWSALALASFQAAATAASSATGPAS
FT AAHGHDNAINPSPADISDTARKLIPLESGPFQVQHCRALLLLCLVSLGRDDWESAWLLV
FT GFAVRVLLVVRTQLPPDDDRPRPRMRALLVACFIVDTIVSMRHNVPAHLKPDDIADLPL
FT PEDGQDQWEPWTPCEGLGGEHTMLQMLRNPAYPLSTFNHLYGVTKLVALELLPRIRTSS
FT QNAPLEFRSRLQQVIGHNSPFSVFVLSQDTASAFVPTAYLTRTVYLWAAAFSEPLNEHY
FT SHLLIETLDQYQKRFGTYAIPPLIPSLLDSLLALKKQSHSSERHRRHLEELFPAYSSIW
FT PRGGRHSNTGLQPIRQLELPPTATATASIMPHVMEQPLSTSINPVNDRFNGIPNPTPYN
FT SDAALDAITQTNDYGSVNTHGILSTYPPPATHLNEASVALAPGGAPPRPPPPYVDSTTN
FT HPPYHSNLVPMANFGYSTVDYDAMVDDLASIEYTDAVDVDPQFMTNLGFVPGCNFSDIN
FT TYEQ"
XX
SQ Sequence 18120 BP; 4494 A; 4760 C; 4757 G; 4109 T; 0 other;
accagtttac aaacagcgct ttgtttggca atacccatct cttaccactt tgccttccac 60
cgtccattgc cggtagttct gagcatgaag gtgaccgttt cgagagctga cacacaggac 120
cgaaatgaca attgattagc gaaacaacca tcgttacccc ctccaacctt ggacgtcaga 180
cagcctaagg aggtctttgt ggcccggact cttgcataga ttaaattcgt gagccgggga 240
tgttacaagt gtcgtgtcac tggcatgctt gggtcagtta tgtttgcgcc aagggtgagt 300
tactagtcac ctttattctg tcatgcctgt ggctttctat atcgctgctg ctttgggatc 360
ccaccatgaa ctgggaaaat cttggccact tgttgatcaa aacggaaaaa aaaaaaaaaa 420
aaaaaaaaaa aaaaaaaaaa aaaaaaaatg aaaaaagaaa aaggacagag tgaaaaggat 480
tataatggat cttctacttc acttcaagca cctggtcgcg tgtagtccaa agcacgcaca 540
cgcctccaaa cttctctgat cgttctctct tgcccttcac gtgctgtctc cccttcagac 600
ggccctgcag gccggacgac gaggtataac cggctaccca gcttcacgtc tggtatctct 660
gccgttgccc aatcttcagg cgggtttgcc gaggttatca gacctccagc ctcctgcagg 720
atcgctatac ctgccgccac atccctaagc ccgtcccatt cttgttagtc aacacttcca 780
agtcaataac tgtgagcagg caaaaatatt gtacgcacca ttcccagcac cctccttccc 840
accagatgtc aaaagaaccc attgccgtgt aagcgagatc cagggtcgcg ctgtttcagt 900
gtcaggactt cgaaaactag aaccaacaag aggggatact gggtataaga gagacttacc 960
ttcccaaact tctgacacca tgcaccattc ctcccttccc gcctcgcccc ccaacctcgg 1020
cagccatatt aacgaaactc tccacctttc ggtacaagtt accttctggc ctgtccttcc 1080
gatccttgcc ccattcgcaa ctaaacacac aaccccccgg tgcgctcttc ggcatcggct 1140
gcctcaccag cggcaaccgt tgtgtctcat taagccaagc accccgccct ttgcaggccg 1200
tgaaaagttg gccaagcatc ggcgcgcata tgactcctat taccggtgtg ccgtcgacga 1260
gaaaggcgat ggagacgcag aacatgggga agagatgggt ataattgacc gtgccgtcaa 1320
gggggtcgac gacccatgtt ggagtcgtat gggtgacgag gtaggggcgc gtggactggg 1380
acgatttcgc gtaggtctct tccccaatga agtcgtggga aggatagcgt gtattgatgg 1440
cagatttgat gaaagcttcg acatcttcgt cggtttgggt tacaatatcg acagcggagt 1500
ccttttcggt gaactcttgg gttgtggatt ccttgtcgtg gttggcattg ttgttgctga 1560
atcgcaagcg ggcagcttcc atgaggaggt tacctgcatc ttttccgagt tggacggcaa 1620
aggtgtagat ttcgtcgagc tcagtcgctg ttgttgttct tgatgtcatg gctgctgaat 1680
actgatatcg aaggagggaa tgaagcacac atactcccaa gtgttgtcgg tagagtcctt 1740
gacaagcagt cgctggtgtc aagggaaaag ccgaatagca agattgagtt aaaacatctc 1800
cattctgacc tactctgtca ctcctcagca tttgctgttc catgggcaaa caaggtgggc 1860
aggggcgggc ttgattccgc ctacggcacc ttacttagaa ccgttggaaa gcgaagaacg 1920
tctaggatgg cctcccgccg agctcaatcg acggaccggc atcatcaagg atggtggaac 1980
ttcggtgatc attaacgcga ggtcccactt tcctgaattg tccaaggtgg tgaatacttc 2040
aacgattgtc tgcattgcac ggatgttccg tcaactacac tattatcagg ttcaatcaag 2100
caccgtgtac cagctcagct tgctacgcgc agtgtgtacc ctttccgcta tatgaatggt 2160
tatctatttc ctacggatac cagcagcttc ttgcggccca tgtgcagacg aactctctca 2220
ttgatggact tttgctgggt aaaacgttcg cccatcaacg gatgagtttt taaccagccg 2280
aaaagaggtg atgcacgggt agtcgaagat ctcggtaaag ccataagctg acagcttccc 2340
cgctcctagg taccaaattt ttctatgcct ttttcttgga taaatcctaa ccctttcttg 2400
gtggctgaag ggttaacgac ttgcacgacc tcaaccactc aaccggaggt atcatgtcag 2460
agaacactaa accaatacag cctcttcacc actccgtacg ttccaatcgt gcaaatcgaa 2520
gacggggggt ctcgcccatt aatccaaggt gcaatggcag aagcagaaaa caaacccatg 2580
acggcctttc gaatggtcat cagtgcagtg acgagcaatg tcacggaagc ggagcgggga 2640
cgggtaatcg cttatccgct cgtcgtgcag acaacttgtc cgtgtattag agatgggaat 2700
gatgagggaa cccgtgatta aacaacaaaa cataaacaca tctcaattca accttctggc 2760
ctgtgagttg ttgggtatag tgcggcggca tctttcggac gcattccctg ttgcgcccat 2820
ctcccacaag cccatcgcac ccaaccagag gtaccaaaca caatggcgtc cccccgtcac 2880
attctcctca tcaatggccc caatctcaac ctcctcggca cccgggagcc ccaaatctac 2940
ggctcaacaa ccctccatga cattgagcaa gcctcccaga ctctggcgtc ctcgctaggt 3000
cttcgtctta caaccttcca gtccaaccat gaaggagcca tcatcgaccg tatccatcaa 3060
gcagcgggat tcgtcccgtc tccaccgtca ccgtcgccgt caagtgccgc aaccacgacg 3120
gaggcaggat tgggtcccgg agacaaagtg tcggccatca tcattaaccc cggcgcttat 3180
acgcacacga gtataggcat ccgcgacgcg cttctgggga caggaattcc gtttgtggag 3240
gttcatgtgt cgaatgtgca tgcgcgagag gcgttcagac atcatagtta cttgagtgac 3300
aaggcggtgg cagtcatttg cggtttgggg ccgtttgggt atagtgctgc gctggacttt 3360
cttgggagac acatgaagtt ttgagaacgg cattgggatg ggatgctaat cttcaacgtc 3420
caagttgaca cctgcataca caagatgaag ctggtcatct tgaatctgtg atatgaggtg 3480
gcgttgatgg tattgtagca gctcacctct agtctataag gttagtatga agggtcgaat 3540
tgaatggtca aagtttagga tctcttttgc ctggatccac gccgaagcag ggggctcaaa 3600
aaacatggga aagcatgctt tgatgtcagg aattataacc ctattaatgt agagcctgga 3660
tgtgtattgt cttccactcg tccaagatga tactacagtc agggtctaga agaaactcag 3720
atgaagaaat catgattgaa tgaaaagaaa aaagacctgg gctcaaggaa tatgtcacca 3780
actcctgata cacgtgccag tctccgattt gtaatccaac gtaccaagag aaaacgaaaa 3840
gaaaaaagag aacaaaaaaa aaaaaaccca gcattttgtg tggactggag tcagtctata 3900
acgataaacc aagtagtaag aacaacaacc gttaaattta caatgaagca gagactcggg 3960
gcatcgtcac caatggcccc tccaccggta tcctcaggtc ttgcaccaac ttggcccacg 4020
agatagcgcc tctcatggca agttcctccg gcacttcagg tccctcctca gacattctgc 4080
ggttgaaaag ctccaaactg acccagccct cgaaaccaat gccgtggaaa agggctcgag 4140
caacctcctt cacgggaaga tacgcaccat attctgtttc gccgtagaac agtctacaat 4200
tgcgcgacca gctcatcctc gccggctgct ctggattgta atacgggtga ccgggcagta 4260
gtggcttgct cagcctctcg gcgtcaacca cctggacgta gaagactttg gagacatcca 4320
cgcgcgagac caagttggcg atggacttcc tgactgcctc ttttgcgttg ggtgtcctac 4380
cgctaggaga tgtagggtcg gcatagatgc ggccgaggat gttgaaggtg tcaaggcaaa 4440
tgccaaagtt ggggcggtca acgcgttgta cgatgtccca gcagcgctcc cagaggtcga 4500
cacgggtgct ccagcaaaga ctctcgtagg caaagcggat agggggcaaa gcttgagctc 4560
caatatcggc caccttgcaa agatctgaga caatcaggtc gaggttgtca ctgacttggt 4620
tggcagggag gaagttggct gggatctgaa tgatgtcggt gtgaagctca tgagcgagct 4680
caatccatag tgctagcttc tccagacgac gctcatgttc tgccctgtcg ttaaggccgt 4740
cgtagtgcat gaaaggctgg aggcagacga cctcaagccc cctggcttga cacatctgga 4800
gaatatgacg agcggcggct atctgagctt cgacaaaagg gccttcggga gagggacgct 4860
cgttcgacaa atgctctgca acgtcgacca gatcctcata aaaaagctcg ataccaagat 4920
agccgtatcg ttgagcggca tcaagcttgc tgtccagaga gtggccggca aagcagcgcc 4980
ctagggacat ggaactaatg gctagctttg acggcatggc gaaaggctca gcgaagtgag 5040
cgtcttgatg ggtcttgaga ataggggaaa aaaaaaagcc gatgttgttg gtggggggat 5100
cctggagaaa taagagatga tgagactggt tcttgatatt gaggtgagat agtgtccttg 5160
aagaactgta tatcacctcg gtgtccttga gcttgtatcg ccaaatggtg aggaaataaa 5220
gcaccaaggt agtcacagga tgtgccccat tgatatgggg agtgaaggca atgaggaagc 5280
agttggggtc ttccaagatt tgatttgacc ttctcggggt ctcattcaat acggcaagcg 5340
ttcctgcgac caagactcga acgtaactcc gcaagcggcc agccgtctcc catcctgaat 5400
cttcaaatga ctaggggtat caaggcactt tcgtctccca taggaggtgt gataaagacg 5460
ccggccgtgg cggtgtattg cagatattcg ggatgtcatc gtttcggttt gcgaagaatc 5520
ggccaataac cgcaacgata agtgatgtaa acggtgaacc gcgggatgga agccgaagtt 5580
tgctcagcgg aataaagcat taacgggtgg gccgaaggta agcgacctat gagcgtttca 5640
caagatttag catctcttca acgatcagat ggcctcgaat gttgacggtc ttggatgacg 5700
ggacgagaca tcttccaccc ttgcgtgtta aacacttagc cggccgtccc gcagttgaca 5760
gcctgtcaag gcaggcacct cgctggccag cttgtatcga gatccagtca tagtacctcg 5820
gattcatatg gaaagggact ttgacagatg aaacacggaa taccgaatcc ttccgtgtaa 5880
tcgtgcaacc tgcgagtacc ggtcttccag ttagctgtct catcgaatgg caaactatta 5940
tgggaagcca cttggtgata ccgcaactat gcaacaattt ggattctggc gcgttgctcc 6000
gtctaagtaa gtatgattga aagtcaacag tgagtgaatg taggtataac taaaacaacg 6060
actccaagtg gctggtccag gtctagaact ttgacagttc actatatgct ctataaccta 6120
cccggactgt gatttcggtt cccaggtaag attccatttc ccgaattcgc gtcttgtccg 6180
ggatagtgtc aattggaccg gtggacactg atgagaagct gcgtaaaatc ggttgccaca 6240
acgctttccg tgggcaaagg tcgagatacc aaaaagaatc ggacaagata acgaacgata 6300
gctgacatgc cttgtgggcc tgtcacacca aaatgtctgg gagccgagaa catgagttct 6360
gtgcatacgt taagagagca agccgttggg tgcccagagg ggttggacag actgctgggt 6420
aagtatttaa gcggtagggc ggctccagtt tgggacgccc ttgcgagttt ggactgccca 6480
aagcaactcg gtacctagca atccccgcaa cagacaggta cccgaaagtg ctcagatctt 6540
ccgaggctgt tgaagagagc tcttccttct aaatcactga aatccccaga gcatgcccaa 6600
aggcaaaacg ctcatcctga atcttttccc ttatgcagga ccatttcgga cgactaggca 6660
gcccagcttc cccaaatccc cgaggacatt cgagcgttct cattcatcct cctccacgaa 6720
gtgctttgtt acgatggaga tgcttagtcg aattgaaccc tgtcaactcc acgcgcccat 6780
gtagtaatga aaatggggga ataacttata gccacgcctt atggcatctc tctcccgagt 6840
tagacgatct cgggaattcc ttaggttctc tctattttca ttccggtctt ctgtcgaatc 6900
ttgattttcg agtgactgtg acttctcata gccagataca ccacacaatc aagcatatat 6960
caccatgtcg acagcaacca ccacaacatc agcgacgacg acgatgtcgg tcgtccagcc 7020
ccgacagcaa gagctccttc acctcaccag cacacccgac atcaccccct acaccagaca 7080
tggctatctc ttcggccaga aactcgcggc ctccatgtcc cctctcctcc actccatcgt 7140
ttactcccac ctctctctca actgggccca acttcgtctt gactccccct ctataccact 7200
cttcctccag ctggcccagc acccagactt ctacggcgcc tcagtgacca tgcctcacaa 7260
agtggccatc atcccgcacc ttgaccacct gactcccgaa tgtcgcgacg tcggcgcctg 7320
caatacccta tttctcaaaa ccgacccagc caccggccgt cgcctgtact gcggcgccaa 7380
caccgacgtg attggcgtgc gcgagagctt cgttcaaaat gtctctgacc ccgcccgggt 7440
atacgagagc cggccggcac tggtaattgg cggcggcggc gcggcgcgat cagccgtgta 7500
cgcgctgcac aagtggctcg gcgcgacgga catctacctc gtgaaccggg acaagagcga 7560
ggtggacgcg gtgattgccg aatgcacgga gcgcgggtac ggcgatcgcc tggtgcatgt 7620
ggcgagcgtg gagcaggctg aaggcctgga ggggccgggg gcgatagtcg cttgcattcc 7680
ggatttcccg cctaagacgg agaaggagat gttggtgagg aggattgtcg agacgttctt 7740
gatgaaggag gagaagggtg ctatgctgga gatgtgctat aaccctagcc cgtttaccga 7800
gttgggagcg ttggcggagc acgaggggtg gcaggttatc ttgggcacgg aggctttgat 7860
ctggcagggg attgagcagg tatgtatccg tcctgagctt acattgtact gtggaggaca 7920
actcaactga tctctcaccc cctttgttct gcaggacaag tattggaccg gtcgtacaaa 7980
tgaggaactt cccattcaac agatcaagga agtcattgct gcaaaattgg cagaagcttc 8040
caaatcgcac accagttgag ataacagggc cctctaagca tgtaaaacga cagtgggatg 8100
aaaacagggt cgctctatag atcgggttgt gacatcggtt gtgatagaaa tagtaaatct 8160
tcgttttaac actgccagct ccacaaacat tgtttcgtgc aaagacatca cgatgtcgga 8220
gtgttgcaac gtagggatgt cttgtcaaaa gcaaaggcac ccgttgccca atcgcaaaca 8280
gaaagactcg gtggctctac aagagtgaag taagaatctc cttgaccacg ggacagacca 8340
aggtatgcgg gagacaatca aaactcagtg ccgtaaaagg gaaaggatac ttgtagaaac 8400
tcaatagtgt gcttcagaca acgcaactgt atacttccgc tttgtagctg tcgatcacat 8460
cagcctcttc aacctcgggc aagaaagtca agtaattaca acaaaggtat cgcccacatt 8520
ccaaacaaaa aattgtatcc acggcggctg gctgccgcag ctcgcaacgt ccctggtcat 8580
attcaagcac cctgaaagca aggcaaattg cagaccttag actgcattct cggtctgtgt 8640
caccctgtcc ttgtcgtcca gcgacgacga ctcctctcgc tctggatttc tgtcgaagtt 8700
gagctcagcc atgagattct tgttggcatt ttgaacgggc ttgatttcaa ataagcgatc 8760
catggcctcg agagggatcg atttggtcac gggtaaaaag aagtagatga acacaatcga 8820
cagcagcatg agcgacgcaa agaagaagta cacgccgtac tccatcttga tgaacatttg 8880
cggcgtgaaa cgagaaatga taaagttcca gaaccagtta ttggccgcgg ctgatgcctg 8940
acccagggac cgtgtgtttt ggtcaaacat ctctgagttg atgacccaag gtgtaccgtt 9000
ccatgaaggg gtgtagaagg cagtccagag gtagaagaag aagatggctg cgatgccgcc 9060
agaggtcagc tttgcgtctt ccgccttgtt cgaccccgga tcagcaatct tgatgtaggc 9120
tccaatgaac cacatgcaga gcgatccgcc agccgcaccg atgaagagta tgcggcggcg 9180
gccaacaaga tcaacaagcc acagaagcca gataatggtg agcaccatct tgacgacgcc 9240
gaagatgcct gttgtcaaga agccggtgtc ggtaccagta atgccgatgc tccggaatac 9300
ggtgggggag taatagttga tggcattgat accactccca ttctgccaga aaaagagcat 9360
gccaccaaga aaaaagcgcc actggacctt gcgctgcttg agggacaaaa acggtttcca 9420
gaacccattg ccgacctgtc gggtatacct ttccaggtca gcgtcaatga atgaaacctc 9480
ttgcacgata tatctgtcgg tgggctcgag attgcgaatc cagcacaaga ccttcattgc 9540
ctcttctctc ttgccattgg cataaagcca ccgtggcgac tcgggaatcc agaagctgcc 9600
caagaacaag aggccggcgg ggatgagctg aaccgcgaag ggaattagcc actgcgacct 9660
cgttggggcc attgtagtgt tgacgccgta gttgatccag aacccgacca gaccaccaat 9720
ctgccagccg agctcgtaaa tgccgacaag acgaccgcga acggcgggtg gggcaagctc 9780
tgagatgtaa atgggtacca tgttggaggc acctccgacg ccgattccag ccagcactct 9840
gcctgcgata atcggatcaa tgcctcgccc ctgaccatca gcagcgagca tgatggcggc 9900
gccaatgatg aagacgacgg agaaggcgat tagggatttg cgtcgaccca agaagtaact 9960
agtcgcataa gcgaatagac atccaaaaaa ggcaccagct tggtaaacgg atacgatgtt 10020
ggactggagc aaggcaagag caccaggtgt gtaagaggcg aaatcgaatt ccttggtgaa 10080
ggacggcagc gcaagggtag tgccaatgaa ggcagagtca tagccaatca tgcacgaggc 10140
aaaactggca atcgccgcgc atgtgtagac gcgccagttg taaacggcct ttggcgttgg 10200
cctatcttcc ttgagcgcaa ggagagtcat cttgacgcgt ctaatgccga ttgacaatat 10260
gatacaagag aaggggggcc ggtgacgcga cctctcttac aagggggaca aagcttacaa 10320
gggggacaaa gggggtgagt gatgcgaacg aggaaagagg gctgaatgta tcctgggatc 10380
tctttgctga agtcgagatg gctcttcttt tgtagaaaag caaatctcaa gggggtacat 10440
gagtattcga ctcatccatg tgcatgggaa cccacgcact aaactagtct tcccttctcc 10500
atggggaatc ttgccgttag caaccatacc ccagccgccc aacgagctaa gatctggctg 10560
gctggtttcc cccgcaagag ccacaccaaa cctgctattc acaagcgacc ggcacaatta 10620
cggatcgtaa ccccagaaaa tccagagtgc atggcaacag ccaaacccca gatgccggga 10680
ctcttcgtgg caaagtgacc gacctgttcc agctcatcgt cagcgtctca gtgtccaacc 10740
cccgagcttc cccgcactga agaagtgaag ctgatgagtg ttgagccggc agctggctgt 10800
ccagtgcaac ccctgctcaa caacgacccc acaaaccgcc gacgtgctag cgcagagttt 10860
ttggagggtg aggatgaatg tataaccggg ggacgacagt gtcgacaacg gtggttgttc 10920
agcccctttc atcttcaacc tctcgagccc ctttacccga gacagcatga ctggccacgg 10980
tcgtaaacgt tgataccgat gagccatcac atctgagaag ctgcatctct gtgcatgaac 11040
ggaaaagcca ttacccagcc agcgcctgat agttcgatac ccagtatcct tgaaactgga 11100
aggtattgtc gaggatatac atatgaggtg gatcgtacac ctcctcttcc tccctccaat 11160
tatcagcgcc aagtgttccc ctcagccgat cgcttcaccg tgctgtcgcg gtgttggtag 11220
cccgtgctga caatagaagt gccggctcca ggagcaaaga cggatctggg tttagtactc 11280
cgagcagatc ttgttgctgt ccgcccaaat cgctccgagt ggtaccctaa tgccgacagc 11340
ccgccccgaa atcaagaccg tgagatccgc atgtctcttt gtttcaagat atttgcgttg 11400
caattccgtt gaggcgaggc tgtaactgcg cggtatgaga ttttgcttga tcatctgggt 11460
atgctcgcaa aacctcgcgc ctcatcaagc gacgaggtgc tcgccgcccg gtgaacagtt 11520
caaattgggc aaacccttgt tctggcaaga ggtcaagtcc atccattgcg acccagcctc 11580
tgtgagcctc gcgtcgtgtt tgttcgagca agggtgatgt gagacatttg tagtcgagtt 11640
ctagtacaat gccgccagtg gggttgtcga gccagtgcaa aggcacagta aattcagggt 11700
caggggtgtt gtccactgtg tgtgtcggta tgcaggaaac gatcatggtc gggtttttga 11760
agttttctgg gagcggatcg tctcgagatc gaatgatgtg aaaacaggtg ttgtcgtggg 11820
atcttggccc tgtgctcaac agaggcaatg cgtctctgac caacaggttc tcgaagtgta 11880
gaaccagctt ctcggcatta gcaaatgttc ggttaaagat caaaatcttc ttgactccca 11940
gttgaagcat ggcatagaca gctgccctag ccattccgcc agcgccgatg acaagaccag 12000
tgcttgttga tctcacggca ttggcgggcg ataaaccgcg gcgaaggcag gctcggatac 12060
caatccaatc cgtgttctcg ccgtagagag ctctgacagc gccggcttgg ctgatattgt 12120
tgaacatgga cacctcgtcc ggtattccac cgtccgcggt aaggtgtcgt accggaatca 12180
aggtgttgac ggctccgatg gctttcgcgt gccggctcag cgagtgtgtg aggctgatga 12240
tttccacctt aaacggcagg ccgaccgagg ctccagcaaa ctgcggatcg ctgataacct 12300
cgcgcaaagt cccgatgttt gctgtggaaa ggggcttgta atggtgtgga atgccacagg 12360
ccttgagtgc ggcattgtgc atggctgggg acaagctata tcccacattt gcgccaaaga 12420
catacagctt cattgggtcg tggacaaatg ccgagtagag agcctgtgtt gcttccagag 12480
ccgtgagcgg aggctggaga tagcgatggg ctggattgcg gagcccgatt gcatcctcct 12540
tggtaggcac tggtgtaact ggagtcagga tctcgttaaa acacatcgat gtccgaccta 12600
ggcgtcctgt gttgtaagca ataaatggga gccttggacc cccgacggcc tctacagcaa 12660
cgtggaactg ccgaatgtct gtgttgtccc ggggatttga agccggtctg gtcaacctta 12720
ccaagtcgca tcctgtattc tgggcctttt cataggcttg taaccaagat ggatcccccc 12780
agcgcggcga attgacctct gcaagttgtt tattgccgat gaccttggtg gttccttgaa 12840
cggtggttag ttgcccaagc aagccagaat cgagccccag atcgaccgta agataatctg 12900
gcgcaagcct taaggcatgg ttcaggtaag tcatgtaaag cgcgagcaga gcttcttcat 12960
atagcgctct ttctggaaag accacgtgca gaatgatggg gatcactgtg tccctcctga 13020
tttcgcctac aacacgactg atctcgctcg ctcggtgggg cgcaagaccc aaggggctcg 13080
ttgggccgga ttcgctcgtt gcaagatcgt ctacaatgat ctcgattgcg tctacaccga 13140
catcaagctc ttggatatcg acgcctttgt cgagcaaggc agatacaggc aaggcgaggg 13200
cgtaggtaaa gcggcgctgt tcaacgggga cggaagccag gggaaaggcg gactcgacaa 13260
aaggtatggt ccccttgggt agaatcaagg agagaaattt gaggaagtgg cgctcggctc 13320
gtttaagcgt tagatacggc gcggtatgcc gctggtccgg aacagcaggt ggtgatgttg 13380
aagcggagtg ggtgtccagg ttctcttcgg agacgttgaa gaactcgaaa cgggtgcagc 13440
ggcgaaggac agtactggtg gcatcaagga gggtgccaac tttggacttg tcgtatccct 13500
tcagatgggc ctcgatagct ttggcatcgc gcagaacgta aatgacagga ttagacacgc 13560
tgaaatcctg caacatggcc tgcacatccc gctccagcca agagcagacg agaatggcgc 13620
gggtcctgtg cagattcaag atgttctgca agatggcgat ctggcgcctc ccatagtcga 13680
ccgggccgtg tgtcttcttg tagctggaac tagacaagcc agtaagatga tggaactcgg 13740
attccaggtc gactatcttg cgcttcatgg cggtagatgc catgatggcc agcgtagact 13800
tgccagcgcc acgaatgccg gcgataacaa tggaagcatc gggatcgaag ctggcggtga 13860
tgggatgatg cggcagcgca cggcggggcg gggaattggg cgccgaccaa gagcctggtg 13920
agactgactg ttagtacgat caagacttga ggtaaaaatc gcgaagcaat acagacgtgc 13980
ctagaggtac tctgtgggcg gaagtgctcc gactattgga gagggttcgt ggtggtcgcc 14040
tggcatgggc accgacatcg ttgctgttgc cagtgtcgtt gtagagcatg gccatggttg 14100
cgaaggaacg cttcatgccg ctggcgacgg aggatgatat gtgcggtaga ggtagaggat 14160
cgcgggcggc gacatccccg acatggcgtg ccgggatggt gttcatgatg gcggcggcgg 14220
cgggggtggt ggtagtggtg tctctatcgc agcggggagt gaaaagccgg gtgcctacct 14280
agttgtgcgc atacttaagt tgtgcatcgg cattctcgca tgcgccatgg caaatgtcaa 14340
ttctgcaaat tggaaactag aggtatgtct ggagaatcac tcatccgatc agaaaatagg 14400
gggaggcttc atgagttttg ttctgtgctt gtcgcagtac agtagcggtc ggttgcttga 14460
ggtcgggaag gaaacagcgt cctctagcat gcaagctgag agatgccagc ccgcccggtg 14520
tgccttcgag ttaataaatg ccttgcggca aagaaactga aaccccctta tattcacacc 14580
ttgcttgcac ttggataagg tacagcgagg tctgtaggta tgtacatgcg gcaagcacgg 14640
aatggaagga gggcgggcat ttaattacct aagtagagag gtaggtactg tcctaggacg 14700
gagcctgcct ctctcatatg aggtgatata cgtccaagcc tccatgtcaa accttccagt 14760
atttacctag gtacagtcat ctgtaaccat ggcgggtgtt ttcacgttaa cggaggtctc 14820
actgcacaaa aggataaaca attatcctcc caacttgggc ctccattttc tctcctctgt 14880
tcacgccgtt cacaactcca acacacctgt ttgtcctgtt gcctcacagg ttcgacaatg 14940
gactataaga ctacctaccg atagtcatat gcttccctga aatctacagg cgaaagtgtc 15000
ttcgaattct cgttggacgt acatcgatgc cacagcaaaa gccgagcttc ccccgcaccg 15060
aattcactac cggttccact gccgtgacgg atccaaacat tcactgccat ccagcttctt 15120
cgctcatgat atcgctatgc acccacctcg gcctctacgc aaccccattc aagccatgat 15180
cggactccca gacacccact acaacgtcgc catggttcgt agagggtcat gaacaacaac 15240
aaaaaaaaaa gatcggcaag ggcatcccat gcgcctgatt cgcaacatat ctctccggat 15300
acacaaatcc caacatgccg cctaaacgca agacactcaa tgccgctgcc gaagccaatg 15360
cccacgctga tggccatgct gatggcaatg ctgatggtca tgtcgctaac actgcagcaa 15420
gcagcaacaa cgcccgtttt gcggacttga ccaacattga cacacccggc ctcggcccta 15480
ccacgacgac gttacttgtc gagcccgctc gttcgaaacg ccagagagtc tcgagggcct 15540
gtgatcagtg tcgagctgca cgtgaaaagt gtgatggaat ccagccggct tgcttcccct 15600
gtgtgtcgca gggccggtcg tgtacctacc aggccagtcc caagaagcga ggagtccaga 15660
cgggctacat ccgcactctc gaactggctc tggcttggat gttcgagaac gttgcccgca 15720
gcgaggacgc cctccacaat cttttggtcc gtgatgctgg ccagggcagc gctctcctgg 15780
tcggcaaaga ctcgcctgct gcagaacgcc tgcatgcaag atgggcgacg agtcgagtca 15840
acaaaagcat cacccgtctt ctctcaggtc aggccgcaca agatccatct gaagacggcc 15900
aatccccgtc cgaagacata aatgtccaag atgccggggc aaagacatcc gacttccctc 15960
atgcgcctca cttgactttc tcggcgccta agtctagtac agctgagaca cgcactctac 16020
caggcccggt ccgaccacct atttcggcaa acaccctgga aaacaacctt cagccagatg 16080
gtaccgggat agggaagcta ccacccaatc attggcgcct gctggatatc tacttttcct 16140
acacgcattc ttggctccct atcctcgaga agaaagacat gtaccaagca ttgtaccagt 16200
actctgaaca aggctcgttg cttccctctg cgaatgtcga gtctggcgtt catgccgagc 16260
tctggagcgc gctcgccctg gcgtccttcc aggctgctgc tactgctgca tcgagtgcta 16320
cgggtccagc ttcagctgct catggccatg acaatgccat caatccttca cctgcagaca 16380
tatctgacac agcccgaaag ctcatacctt tggaaagcgg gccgttccag gttcagcact 16440
gcagagcgtt gctgcttctt tgtctcgtaa gccttgggcg ggatgattgg gagtctgctt 16500
ggttgctggt tggctttgcg gtccgcgtcc tacttgttgt tcgcacccag ttgcctcctg 16560
atgatgaccg gccacgacca agaatgcgtg cgctgctcgt cgcgtgcttc atcgtggata 16620
ccattgtgtc tatgagacac aacgtgccgg cccatctcaa gccagacgac attgcggatc 16680
tgccgttacc tgaagacggt caagatcaat gggagccgtg gacaccatgt gagggcttag 16740
gcggtgaaca caccatgctg caaatgttga ggaacccggc atacccttta agcacattca 16800
accacctata tggcgtgacc aagctggttg ctttggagct tctgccaaga atacgaacat 16860
cttcacagaa cgctcccttg gagttcaggt cgcggttgca gcaggtaatc ggccacaatt 16920
ctcccttcag cgtctttgtc ctttcccagg atacagcatc ggcttttgtg cctactgcat 16980
accttacccg taccgtttat ttatgggcag ctgccttttc tgagcctctc aacgaacact 17040
actcgcatct tctgatcgaa actcttgatc agtatcagaa gcggtttggt acatatgcaa 17100
tcccacctct gatcccttct cttctagact cccttcttgc tttaaagaaa caatcacatt 17160
cttcagagcg gcatcgaagg cacttggaag agcttttccc cgcctactcc tccatttggc 17220
ctcggggagg ccgacacagc aatactggcc tccaacccat acgacaactt gagcttccgc 17280
cgactgcgac tgccactgca agtatcatgc cccatgtcat ggaacagccc ctgtcaacgt 17340
caataaatcc ggtcaatgat cggtttaatg gaataccgaa tcctaccccc tacaatagcg 17400
atgcggccct agacgcaatt actcaaacca atgactacgg atcagtcaat acccatggca 17460
ttctcagtac atatccacca cctgccaccc acttgaacga ggcctcggtg gcccttgcgc 17520
ctggaggtgc tcctcccaga ccacccccgc catacgttga tagtacaacg aaccatcctc 17580
cttaccatag taacctcgtc cccatggcca atttcggata ttcgactgta gactatgatg 17640
cgatggtgga tgatctggca tcgatcgagt acacggatgc ggttgacgtt gatccgcagt 17700
tcatgacgaa cctcgggttt gtcccagggt gtaattttag cgatatcaac acgtatgagc 17760
aatagttggc tattcgaagt tgagaaaaca tacaaacaca tacaaagaca tacagatatg 17820
cggcacacat gcactaaaaa aaaaaaggaa ggaaggaagg gggtgcccag aagtatttgt 17880
gttctcgtga agaacacaac ggcatttggt agtttcgcta cacaaaatga ccactttgat 17940
aataactcgt gacaaacaga cacttgcgag atacctactc ccacctatgg tggaaggacc 18000
attcgggacc gtcacctcgt ctttgagtgg cagtgaatca gcaggacagc cttacgagat 18060
cattgtgtac gtatagtggc ccaagactcg ttttcgcttc tactatgtaa gtctaccatc 18120
//
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