 |
|
EBI DbfetchID X14445; SV 1; linear; genomic DNA; STD; HUM; 11608 BP. XX AC X14445; XX DT 09-JUN-1982 (Rel. 01, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 6) XX DE Human int-2 proto-oncogene XX KW growth factor; int-2 gene; proto-oncogene. XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RP 1-11608 RA Dickson C.; RT ; RL Submitted (27-FEB-1989) to the EMBL/GenBank/DDBJ databases. RL Dickson C., Imperial Cancer Research Fund, P O Box 123, Lincolns Inn RL Fields, London, WC2A 3PX, ENGLAND. XX RN [2] RP 1-11608 RX PUBMED; 2470007. RA Brooks S., Smith R., Casey G., Dickson C., Peters G.; RT "Sequence organization of the human int-2 gene and its expression in RT teratocarcinoma cells"; RL Oncogene 4(4):429-436(1989). XX DR GDB; 1231223. XX CC tissue=placenta; library=cosmid; clone=C1; CC CC Data kindly reviewed (04-Jul-1989) by Smith R. XX FH Key Location/Qualifiers FH FT source 1..11608 FT /organism="Homo sapiens" FT /chromosome="11" FT /map="q13" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT exon <936..1155 FT /number=1 FT misc_feature 445 FT /note="pot. transcription start site" FT misc_feature 479 FT /note="pot. alt. transcription start site" FT misc_feature 507 FT /note="pot. alt. transcription start site" FT misc_feature 527 FT /note="pot. alt. transcription start site" FT CDS join(936..1155,3445..3548,9197..9592) FT /product="int-2 preprotein" FT /db_xref="GDB:120103" FT /db_xref="GOA:P11487" FT /db_xref="HGNC:3681" FT /db_xref="HSSP:1NUN" FT /db_xref="InterPro:IPR002348" FT /db_xref="UniProtKB/Swiss-Prot:P11487" FT /protein_id="CAA32615.1" FT /translation="MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRR FT RKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGR FT LYASEHYSAECEFVERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRP FT RRGFKTRRTQKSSLFLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEP FT SHVQASRLGSQLEASAH" FT sig_peptide 936..986 FT mat_peptide join(987..1155,3445..3548,9197..9589) FT /product="int-2 protein" FT intron 1152..3444 FT /number=1 FT exon 3445..3548 FT /number=2 FT intron 3549..9196 FT /number=2 FT exon 9197..9929 FT /number=3 FT polyA_signal 9911..9916 FT /note="pot. polyA signal" FT polyA_site 9929 FT /note="polyA site" XX SQ Sequence 11608 BP; 2166 A; 3822 C; 3181 G; 2439 T; 0 other; ggatcctccg aggcctgcca gacgagagct aaccccacca ctccgggtgc ccagttggtg 60 tgcgcaaaag gagatagcat ctccagaccc ggcctgcccc gcgccttgca aggctgagga 120 cagcgccact gctcctgcag gaagcgccgg gcgcagacac aaacccggag ctccccacgc 180 gtgcccgcgc cccggagcct ccccgccgcc gccctccgcg gtccccttca ttatgcgccg 240 cctttaatgg gcgtttgtca gctcgacttc cccgcaagtt gttttcacgg acatcagtca 300 tcggcggcgg ccccattgtg cagggggatt gatggggagc gggagggggt gacagggcct 360 ggggcggcct cctcaaggcc tcggtctata attttcggag gcataattgg tctgggggag 420 ggggcggggg aggggcgggt aggggacctt tcagagccag gagggctttc gggggcgtgg 480 ggcgcgctgc ggagcggagc cgcggctcga cggcggtgcg ctggcggcga gtgtatgcag 540 acggcgcccg gcccgaaccc cgagccccgc ggggctcccc acccgccggc ctcccgcccc 600 tcccgcgcct ccgcctgggg accacgtcgg ccttttgttg gcgaaccgtc ctttctttca 660 gcgctttgcg cagcaacgga aatttcattg ctcctgggtg gaaattaaag ggactcgcgt 720 tccctctctc cctctccctc tcccactctc cctctctttc tctctctcgc ccacccttcc 780 cccttcttcc cccacctttc ccgcgaagcc ggagtcagca tctccaggcg cgggatcccg 840 ctccgagcac ctcgcagctg tccggctgcc gccccttcca tgggcgccgc gctcgcctgc 900 agccgccgcc gccgcggggc gggcgcgatg ccacgatggg cctaatctgg ctgctactgc 960 tcagcctgct ggagcccggc tggcccgcag cgggccctgg ggcgcggttg cggcgcgatg 1020 cgggcggccg tggcggcgtc tacgagcacc ttggcggggc gccccggcgc cgcaagctct 1080 actgcgccac gaagtaccac ctccagctgc acccgagcgg ccgcgtcaac ggcagcctgg 1140 agaacagcgc ctacagtgag tgccggacgc tgcggggccc cgggggaagc ggcgccggga 1200 ggggtcgggc ccgggagaag gcgcgctgcg gggccccgcg ggggaggcgg cgccggggag 1260 gggtctggcc cgggagaagg catggtgcgc ccggggtgtc cgggaaaaga ccgtctgcct 1320 cccgctgcca gaaggggaat gccagggtgc cctcctcaac ctacacgtcc gggagaagag 1380 cgcgcgctgg ggttcgagca gaactcgggg gcatgggcgt tcacgtccga agagggcgcc 1440 ggcggctgtc agagtccgtc cccggtccgg cccgctggtc tgaggggacg cgagctaggc 1500 gaccccgggg ctccaggctc tgctgctttg ggcagctctg acaagtttaa gccctttgaa 1560 tgtgtcggag aaaaggagcc ggacaaggca tttatcatct tctttattat tttgacgact 1620 tctcctcctc ctgccgaccc ctggacgccc cgccgtcccc tccgccctcc ccgctcgcgg 1680 ctgcccaggt ggccgccccc gctgctgcct ctgcgcggag gactcttgcc ctgcggagct 1740 cggttccctg gccgcggccg ccaccgacag ttttccccgc gctggaatct gcacctcccc 1800 cgcctccgcc ctggccgcac agcgacagga gggtggaggc cctcgccgtc gggacgtgcg 1860 gatcacgagc gcggaacggt gtccgcccgg gcctgggggt gcagacacac acactccggc 1920 ccccgcacgc aggacccgcg gcccgggctg cgctcaccgc gggagtctgc cggactacac 1980 ggttgggctc ctctggtcac agggacctga ggcccgcgcc gagccctttg aggagcagga 2040 tagcggagct cagggcccgg gaggaccgcg tggggagcgt gggagggcag tcaagaccac 2100 agctgtcctc gggtgctccg cgcggcgctc ggctccggcc ccgggcgcag gaagcggttc 2160 cgccgcttga aggtggcggc ggcggcctca gcaaaccgcg gcttcctcca ggaaagccgc 2220 agccctgaga gggcgtcctg gggacatgcg cctccggagc cgcacggtgg gcaccagctg 2280 tcaccagggg gtccgagtgc gcggaattcg tctcactaag acactccggt tctctccaaa 2340 gccaggctcc ccctcggagt ctcacagcat ccaaacttct tggtgttggc tgctcacggg 2400 gaggggaggg cgcgcgcccg cagccgcccc tgtcctgcgt cgagactcgt gcttcgctgg 2460 tccccggtca ggcaccgccg atgccgccca gcctgcgcac tgggaaggcg ggaggctcgc 2520 agcctgcacc acagcacccc tgggctggag caaaagcccg gtggtgaccg cgtctgtgct 2580 cggaccgcgt gccaggaggg cgctcctgag aggcatgcct tggagagggt gcaggcagtc 2640 gccccaatcc cctcgcagcc tctattggga gacaatgacc ccaacccgtc ctttgatgta 2700 gtcccccgcc cccagccccc accacagcac tcgtgtatcc agaaggaaag gcgggagggg 2760 agatttaaac tttcttatcc ctggggagtg ggtgagaccc gtccagcttc cctctgcggg 2820 ctccagggtc taaactggct tcctgccctt ccaggtcccc cggcgagtac aatgatctcc 2880 cgccaggtct attgccagca tgatttgggt ggcaggcacc ctggctgtgt tattgccagt 2940 ggtttatatt atcagcctgg ctcatcaggg cccagctttc ccgctggcag gcacaggcat 3000 tggggaccgt gcagtcccag agctcagact cccatggctg ccgccagggc ttgatttccc 3060 gctcaagcac atgtgcaggg gcctgacagt cacccagcca tagtggtccc cacttgcttg 3120 tctgtcggat gatgatggca gctggcaagg tgttgtgagg ctcgaatgaa agccagggtg 3180 caggcagcgt cagcaggtgg gaatgttaat ttcattgtta ccctcccaag tttgaatgaa 3240 gagaagcctt ccctgatgtt cccttctcta cctcctgtcc ggtgacttct cccttcctga 3300 acttccactc actccccgac ctgtggggtg tgtgctaccc tccccagccc tgagcccggg 3360 gtgtggcttt gggcagggcc agctgggcct cagccgcccc ctccgtgggg gcggcgggag 3420 tgaggcacct ctcatttctt ctaggtattt tggagataac ggcagtggag gtgggcattg 3480 tggccatcag gggtctcttc tccgggcggt acctggccat gaacaagagg ggacgactct 3540 atgcttcggt gagtccaggc tgtcacgtgg gtgggcgctg acggagtagc ggtctggcct 3600 gcacatcaag ccaggggacg ggggatgtgg gcagtagaat gctttgccaa gggtacatgg 3660 gatccaagct aggaccagac cctggcccag ggctccacgc ccagtgatct ttggctgtgt 3720 ctgttagagg ctgctccgcg agtgacctgg agcctggccc tgggggacct gggatctgga 3780 gaatgccagg ttagcaaagg tttcccccat ccttgtcatc actaccaccc tcccttgaga 3840 gtagctgaga gcagggaagt gattgttctc caaatttcca ccaaaataaa tggacccaag 3900 acaacctggg agtgttcctt ggggcagcca gagctctcct gggagcatgg agaggagggc 3960 gctggcccag ctccaccggc tctctccaag ggtggaaagg cgagagctga agcctaggag 4020 gggaaggggg atggcgccca tgtcccgggc acacaggagc cttggagccc tggcttggga 4080 cccagtctat ctactgcctg ggcctccgtg taaccaaaaa gggtctcctt attctgtggg 4140 tatggcagcg cccctcttca taaggggtag gggtggggaa tacacagagt aaaatacatg 4200 tcacagggaa atttgctacc tccaactagt cattacatgc aatttggctg atacttcctt 4260 gggcaatgag aggttttcca tccatgagta gcctggctga cgcggcccaa ggacaatctc 4320 cctgcagtga gctctctgct cagtcctgct cacagaggac acatcccgca gctccctctc 4380 gcagaagctg atgatttcat cacagatttt tagccgtttt gctaaaggaa ggtccagaaa 4440 gccgggatgc gccccttcat tttctctggt ccagaggcta ctccctcctt cctcccatcc 4500 actcacccat ccacccatcc acccattcac ccatccactc atccacccat ccacccatcc 4560 atccatccac tcatccaccc atccacccat ccatccatcc acctatccat ccatccatcc 4620 acccatccac ccatccttcc atttacccat ccaccatcca cctatccatc catccatcca 4680 cccatccacc catccaccca tttacccatc cacccatcca cccatccacc tatccatcca 4740 tccatccatc cacctatcca cccatccact catccactca cccatccacc tatccaccca 4800 cccactcacc catccatcca cccacccact cacccatcca tccatacacc tatccatctg 4860 acattcagtc cattcatcag tcagtgtcct ggaagctgtg tctgggagca ggggccctca 4920 tggtgccagc ttctgccata ggggagccag gatttggaga gacagaataa agcatgacat 4980 gagggggtcc cagtggttca gagcccacct ggggcttccg tgcctgagaa ctcacagcct 5040 ggctttgaga agggtggaca gaggctccta gccccaccag ggatgcttag ccaagcagtc 5100 tggctggagg gtgtggaact ttccagagtg cccagtggag aagttcccat tgccctgcag 5160 acaacctggg aggcatagta gcctggatgc caactccgtc acctgccacc tgccacctga 5220 taccacagtc ctgcgtgtgg ccagcttgcc taggagtgct gtcccaccac ggggctccct 5280 ggactttgcc ggcagcatgc ttgccctcag gccagctcat ctcactgtgg gccagtgagc 5340 actgcaccct gacactcctg gtctggccct gacctccctt ctgaggtata gaccaccctc 5400 ccccaacatc ctgctgactc agacactcca accgaactca gcagctcccc gactccccat 5460 cttaatcatt gccccaccag ccactcactc tcacccagag tggactggga gtcatggtag 5520 acccctcctg ctattcagtc catccctagt cctcagacca cgcccctgca tctcttcagc 5580 ccacacacct cacctccctc tgcctcatcc ccgagagcac gccttaaaag gcaggctcat 5640 cacttcccac ctggatcact gctccagcct ctcctacctc cagtccatct gtttgtcaag 5700 ccatccatcc atcttccttc cttctttccc cttcctttat tctcttcacc catctgtcca 5760 tacacctctc cttccttcct tctttccttt ctctcatcct tctttccatc catccttcca 5820 accgttcatc tgtccatctg cccattcaca tgtccatccg tccatgctcc ctccttcctt 5880 ccatcctttc acccatccac ccatccaccc atccacccat ccaccaatcc atccagcaat 5940 ccacccatcc atccagccat ccacccatcc atccgtccac ctatccatcc atccacccat 6000 ccatccaacc agccatccac ccatccatcc atccatccat ccatccatcc atccacccac 6060 ccacccatcc acccatccat ccatccagcc aaccagccat ccacccatcc acccatccac 6120 ccatccatcc atccatccat ccatccatcc atccatccat ccacccatcc acccatccat 6180 ccatccagcc atccacccat ccatccatcc acctatccat ccatccacct atccatccat 6240 ccacccatcc atccatccag ccatccaccc atccatccat ccacccatcc acccatccat 6300 ccatccatcc atcaatccat ccatccatcc acccatccat ccatccatcc acccacccat 6360 ctgacattca gtccttcgtt caccagtcag tgtcctgggc acttaccatg tgttgcactc 6420 tgctagtgca tgttaaaggg gcttcctaaa aaagcaaatc agcccagttc atggcttctg 6480 aggactccca tgatgcgcag gcatccccca ggcaccttag ctccacccac agagcagcag 6540 cccaggtgcc atctgctccc aggggggccg tcatccagag gttgagcctc ctccagcttc 6600 cggaagcccc ctcaactctc caagccatct gtactgctca ggccacacct tcactgcctg 6660 gaacgccctc ctccagaaaa tgcccatgag aaagtgcccg ccccgccctt acagctccct 6720 ttagaagtca cctcctcaac aaagcagctt cggagtcggc ttcctcccca cccttcatgg 6780 ggtggaagcg gccctggggg aggggcctgt ggaaccaggt ctggtggggc ggcagtgtca 6840 ggacacacat tggaaagtgt tgtcacagcg agtcccaact gcagtagctc tggagtctat 6900 ggccccggcc cctgagccaa caccttctgc cctggtcatc ttggccaccc caggtgccct 6960 accacgtgtc agcaattgat ctacactgcc cccaatctcc cacctcggga gagcctgagc 7020 cccctgccac ctgaggctca caggcacctg tccttcagtg acccacccct caagtggccc 7080 cccaaagaga aagcctattt cctggcctct ctggccctga gaggactcac ctgctgcagg 7140 atcgagggac ctgggagaag cttgggtcct gccctgagct tctcacagtc tgccatggga 7200 gccagacact aacatgttgt acccagtgtg tggggtgggg aagtcggccc tgagcccacc 7260 cgctcattcc cagatagtcg ctgagcccca ggctatgtgg gggtcaggca cagatcagac 7320 actgttctat cccctgtaat gtagggcctg gcaccacccc tgggcctcag tttccccatc 7380 tataaacatg gagaccggtc ttggatagta acatccagac tgtggcccag ggggcactgg 7440 gcctccaaga gggctggaga gcaggggggc ttggggttat ggggagaggc agcccctacc 7500 accaggtcaa gccttccacc cttccctgct ctgggctttc atgtcgctga aaaacaggat 7560 ggggtgcttg aagcatcttg ttccctgagg tcctgcgagg tcagatgctg ctcggtccag 7620 tctgggagcc tctggaggcc atttccactc tccctctctc ccacgggaca ccacacccca 7680 gatggggaca gaccatgagg gcctccgact cctcctgcgg ccagtcccca ggaggaaaga 7740 gagatcctac tgtctgcctt gcacctgctg cttccacctc ccaccaccct ttctggtttg 7800 gagggagcag ctcctgtcag tcatcccctg agggaggtgg ccctaggcat taccacttgc 7860 ctgtagctgg gactgaagcc tagtgggtct gcataaggca tacccacctc ttccctacgc 7920 cacagactaa gaagacccca tgaggcagcc cttgagggaa actcccacgg ccaggccttg 7980 gggatgttgg tgtaagctcc ttcagttcag agcttcactg tgcctttgag agggcagggt 8040 cccttctgcc cttcccccac tgcaccctgg gcctgacaag ggtcccatta atctctgatg 8100 acaaagaggt gtcctctctg tcctgcttgt ggtgggacac cccagcttct gctctcatcc 8160 taagaacagc agtatctgtg gcactgattg atcacgtgcc tcatgccagg ccccagcccc 8220 tgctctgtgt tgtaacctct tcaacctgca aggcgagatc ctccagctta agagagtgtt 8280 gctcaggggt caatgacccc agctggggcc cctgagcgca gcgtttaatg gagagtctgg 8340 gctcatcaaa cctggctgtg tccccttccc ttcctgcttt ttgtgttctt tcttcttttt 8400 acttttctgc aatttctttt tttttctttt cttttttttt ttttttgagt cagagttttg 8460 ctcttgtcgc ccagactgga gtgcagtggc acaatctctg ctcactgcaa cctctgcctc 8520 ccgggttcaa gtgattctcc tgcctaagcc tcccaagtag ctgggattgt gggcgcacgc 8580 caccacaccc ggctaatttt tttgtatttt tagtagagac ggggttttgc catgttgccc 8640 aggctggtct cgaactcctg acctcaggtg attcacctgc ctcggcctcc caaactgctg 8700 ggattacagg catgagccac cgtgcccagc ctctgcaatt tctttaaaag agatctgggt 8760 gttgtcatct tcctttgtcc aaatgcccag tccttgctga cctccacact gccagcagac 8820 tgccagggca cctgggttgg ccggcctggt ctctgctcca cagacaaccc tacacatccc 8880 tttgctgtgt cagcgccctc agatggggga cagaggctgg tggaacccag agagtaggag 8940 ctgggagttg tctggcacag ctttgagtga aggtgacctt taggcagaag gccaagttca 9000 ccaggcacac aggggaggaa ggacatgctg ggcagagggc agggcctagg caaaggtgtg 9060 actggctgag agtgcgctgg ggtttggcac tggaccgaac agcctcacag gaggggaggg 9120 aggcatcagg caaccctggg ccctgacgct gccgcagtct ccccggggca ctgaccatga 9180 tatctcatcc ccgcaggagc actacagcgc cgagtgcgag tttgtggagc ggatccacga 9240 gctgggctat aatacgtatg cctcccggct gtaccggacg gtgtctagta cgcctggggc 9300 ccgccggcag cccagcgccg agagactgtg gtacgtgtct gtgaacggca agggccggcc 9360 ccgcaggggc ttcaagaccc gccgcacaca gaagtcctcc ctgttcctgc cccgcgtgct 9420 ggaccacagg gaccacgaga tggtgcggca gctacagagt gggctgccca gaccccctgg 9480 taagggggtc cagccccgac ggcggcggca gaagcagagc ccggataacc tggagccctc 9540 tcacgttcag gcttcgagac tgggctccca gctggaggcc agtgcgcact agctgggcct 9600 ggtggccacc gccagagctc ctggcgacat cttggcgtgg cagcctcttg actctgactc 9660 tcctccttga gcccttgccc ctgcgtcccg cgtctgggtt ctcagctatt tccagagcca 9720 gctcaaatca gggtccagtg ggaactgaag agggcccaag tcggagctcg gagggggctg 9780 cctgcaatgc agggcatttg tgggtctgtg tggcaggaag ccggcaggga agggcctgag 9840 tgccagccct ggcagactga ggagcctccc aggagcagcg gggcagtgtg gggctttgtg 9900 tcatcacaac attaaagtat tttattctac tctgtcgttt ggtagaccgt gatgcaggct 9960 gaggagcgct tgccgccttt actggaacgt gcttgcttcc agcacagcag aatccgcgct 10020 ggcatcagcc tgcgtcagct gctgctttaa gaggaagacg gcattcccag aaatcgggct 10080 aaaggtgcat ttcagttccc tggttttaga aagttacgtt tttttggatg gttggaaaca 10140 agcaaaggca tgtttgtgca tgtgtgtgca tcgtgtgtgt gtgcgtggag agaaggatcg 10200 tgtatttctg aaagcgtgag tgtgcatgtg ggtatgtgtg atcttgtgtt agtggtacct 10260 gtgtgaggac atgtatgtgt gtgtgtgttt ctgggtgtgt ctgaatgtgt gatgtgtgtg 10320 tgtctgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtggaga gagagagaga gagtttactt 10380 tctttgaaaa ctctaaaaag cctctccctc tggaagctgt gtgcttctcc agggaccctt 10440 tagagcaact gtgtcaggtc aggcagcaca gaaacttcct ttatccttac aacctgctct 10500 tggggcccgt gcaccctgtc tttacctaga aggtgaggct cagagaagca attactcagt 10560 ggccggcccc tgccttggac taggtgcctc ctcacacctg ttccccaaca atggcatggg 10620 tggaatcacc tgggccggcc caggtgagag ccagcatggg cagtgtacta acctctcctg 10680 gcacttggca ggatgggcag ggtccaggtg aggaggctct cctgagcctg ggactgtgag 10740 gaccatcgct ctctgttccc atgccctccc aggggtcaga gagcccagac tcagagagcc 10800 cagggtcaga gaacttaggg tcagagaggc cagagtcaga gagctgagac tcagagagcc 10860 cagggtcaga gtgtccaggg ccagagagct tgtggtcaca gagcccagac tcagagagcc 10920 cagactcaga gccacctgat tggttagtgc agactcgcca aacccacagg gaggctgggc 10980 tcctccctgg cacgtgtgca acacaagtga aaatctcggt gcctccttca gcccccagcg 11040 catgtcagat ttcccggaat ggctcccctg cagctgcgaa cattcctggc agtcaacagg 11100 agcagcacgc agctgagctc tgctgtgggt tttgttgttt ctctagagtg agatggggca 11160 ggggctgcca tcactccctc cttgcagatg atgaccctga gtcctggcaa ggggaacttg 11220 cccggggctg tgtcaacaca ggggaagcag cagtactcag tgctgcagga tcaacagatg 11280 gtccctgatg aaggcgtagg agacactggg ggctcttgtt taacatgtaa aacagctttg 11340 acaagagaat gtggattttt cgcagctgat ggctgtgcca tggtcacctt cttccccaca 11400 ccagagtcca agggacttca ttttgtgtgt gtgtttgggg ggtcatgggc tgaattatgt 11460 ctcctcccca gagttcatct gttgaagtcc taacccctag taactcagca tgtgacctta 11520 tttggaatag ggtcattaca gatgcaactg gtgaagatga ggtaacatag gagtagaatg 11580 acccctgaat ccattgtgac caggatcc 11608 // |
|