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EBI DbfetchID X02369; SV 1; linear; genomic DNA; STD; PRO; 10664 BP. XX AC X02369; S89977; S89997; XX DT 02-JUL-1986 (Rel. 09, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 21) XX DE Bacillus subtilis oriC region XX KW 16S ribosomal RNA; inverted repeat; origin of replication; ribosomal RNA; KW unidentified reading frame. XX OS Bacillus subtilis OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. XX RN [1] RP 1-10664 RX DOI; 10.1093/nar/13.7.2251 RX PUBMED; 2987847. RA Moriya S., Ogasawara N., Yoshikawa H.; RT "Structure and function of the region of the replication origin of the RT Bacillus subtilis chromosome. III. Nucleotide sequence of some 10,000 base RT pairs in the origin region"; RL Nucleic Acids Res. 13(7):2251-2265(1985). XX RN [2] RP 1-10664 RX DOI; 10.1111/j.1365-2958.1992.tb01473.x RX PUBMED; 1552845. RA Moriya S., Atlung T., Hansen F.G., Yoshikawa H., Ogasawara N.; RT "Cloning of an autonomously replicating sequence (ars) from the Bacillus RT subtilis chromosome"; RL Mol. Microbiol. 6(3):309-315(1992). XX DR UniProtKB/Swiss-Prot; P37525; YAAB_BACSU. XX CC ORF 638 and ORF 821 were identified as gyrB and gyrA genes. CC Comparison of amino acid sequences revealed that ORF 44, ORF 446, CC ORF 378 and ORF 323 are homologous with rpmH, dnaA and recF of E. CC coli. Two non-coding regions characteristic for oriC signals were CC found. One region is upstream of ORF 446 (region 1) and the other CC between ORF 446 and ORF 378 (region 2). They are characterized by CC repeats of 9 nucleotides (direct repeat 1) whose consensus CC sequence, TTAT (C/A) CACA is identical to that of the repeats found CC in the oriC sequence of the E. coli chromosome. Pairs of repeats CC may form stem loop structures. XX FH Key Location/Qualifiers FH FT source 1..10664 FT /organism="Bacillus subtilis" FT /mol_type="genomic DNA" FT /db_xref="taxon:1423" FT repeat_region complement(401..410) FT /note="imp. inverted repeat A'" FT repeat_region complement(417..426) FT /note="imp. inverted repeat A" FT misc_signal complement(401..426) FT /note="put. transcription termination signal (ORF 44)" FT CDS complement(425..559) FT /transl_table=11 FT /note="pot. ORF 44 (aa 1-44)" FT /db_xref="GOA:P05647" FT /db_xref="InterPro:IPR000271" FT /db_xref="UniProtKB/Swiss-Prot:P05647" FT /protein_id="CAA26216.1" FT /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA" FT RBS complement(566..572) FT /note="pot. Shine Dalgarno sequence (ORF 44)" FT misc_feature complement(577..579) FT /note="pot. transcription initiation region (ORF 44)" FT misc_feature complement(584..586) FT /note="pot. transcription initiation region (ORF 44)" FT misc_feature complement(594..596) FT /note="pot. transcription initiation region (ORF 44)" FT promoter complement(606..611) FT /note="pot. -10 region (ORF 44)" FT promoter complement(630..635) FT /note="pot. -35 region (ORF 44)" FT misc_feature complement(661..665) FT /note="pot. transcription initiation region (ORF 44)" FT repeat_region complement(770..778) FT /note="imp. direct repeat 1" FT repeat_region 797..805 FT /note="imp. direct repeat 1" FT repeat_region 810..818 FT /note="imp. direct repeat 1" FT repeat_region complement(841..849) FT /note="imp. direct repeat 1" FT repeat_region complement(875..883) FT /note="imp. direct repeat 1" FT promoter 898..903 FT /note="pot. -35 region (ORF 446)" FT promoter 921..926 FT /note="pot. -10 region (ORF 446)" FT misc_feature 931..935 FT /note="pot. transcription initiation region (ORF 446)" FT repeat_region 969..977 FT /note="imp. direct repeat 1" FT repeat_region complement(981..989) FT /note="imp. direct repeat 1" FT repeat_region complement(1014..1022) FT /note="imp. direct repeat 1" FT repeat_region 1025..1033 FT /note="imp. direct repeat 1" FT RBS 1165..1172 FT /note="pot. Shine Dalgarno sequence (ORF 446)" FT CDS 1186..2526 FT /transl_table=11 FT /note="pot. ORF 446 (aa 1-446)" FT /db_xref="GOA:P05648" FT /db_xref="InterPro:IPR001957" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR010921" FT /db_xref="InterPro:IPR013159" FT /db_xref="InterPro:IPR013317" FT /db_xref="InterPro:IPR018312" FT /db_xref="InterPro:IPR020591" FT /db_xref="UniProtKB/Swiss-Prot:P05648" FT /protein_id="CAA26217.1" FT /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTITA FT PNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKEDTS FT DFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHA FT IGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQFLAGK FT EQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETR FT IAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAE FT ALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMYLSREMTD FT SSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK" FT repeat_region complement(2553..2561) FT /note="imp. direct repeat 1" FT repeat_region 2573..2581 FT /note="imp. direct repeat 1" FT repeat_region complement(2593..2601) FT /note="imp. direct repeat 1" FT repeat_region 2628..2636 FT /note="imp. direct repeat 1" FT misc_feature 2650..2697 FT /note="AT cluster" FT misc_feature 2681..2683 FT /note="pot. transcription initiation region (ORF 378)" FT RBS 2703..2708 FT /note="pot. Shine Dalgarno sequence (ORF 378)" FT CDS 2715..3851 FT /transl_table=11 FT /note="pot. ORF 378 (aa 1-378)" FT /db_xref="GOA:P05649" FT /db_xref="InterPro:IPR001001" FT /db_xref="UniProtKB/Swiss-Prot:P05649" FT /protein_id="CAA26218.1" FT /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSFT FT GSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQYLT FT IIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRPILT FT GVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDNQELV FT DIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAIDRASLL FT AREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKYMLDALK FT VLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY" FT misc_signal 3863..3882 FT /note="put. transcription terminal signal (ORF 378)" FT repeat_region 3863..3871 FT /note="inverted repeat B" FT repeat_region 3874..3882 FT /note="inverted repeat B'" FT misc_feature 3956..3960 FT /note="pot. transcription termination region (ORF 71)" FT RBS 3967..3974 FT /note="pot. Shine Dalgarno sequence (ORF 71)" FT CDS 3982..4197 FT /transl_table=11 FT /note="ORF 71 (aa 1-71)" FT /db_xref="GOA:P05650" FT /db_xref="InterPro:IPR002942" FT /db_xref="InterPro:IPR014330" FT /db_xref="UniProtKB/Swiss-Prot:P05650" FT /protein_id="CAA26219.1" FT /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDEP FT DNRRGRKLYVGDVVEIEGFGSFQVVN" FT RBS 4330..4339 FT /note="pot. Shine Dalgarno sequence (ORF 323)" FT CDS 4354..5325 FT /transl_table=11 FT /note="ORF 323 (aa 1-323)" FT /db_xref="GOA:P05651" FT /db_xref="InterPro:IPR001238" FT /db_xref="InterPro:IPR003395" FT /db_xref="InterPro:IPR018078" FT /db_xref="UniProtKB/Swiss-Prot:P05651" FT /protein_id="CAA26220.1" FT /translation="MAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGK FT KGKVNHIEQQKLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLS FT LYQKILSQRNHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPI FT HAGISRGLEELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDD FT VLFYVNGRDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQS FT HLLHTIQGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK" FT RBS 5623..5630 FT /note="pot. Shine Dalgarno sequence (ORF 638)" FT CDS 5642..7558 FT /transl_table=11 FT /note="ORF 638 (aa 1-638)" FT /db_xref="GOA:P05652" FT /db_xref="InterPro:IPR001241" FT /db_xref="InterPro:IPR002288" FT /db_xref="InterPro:IPR003594" FT /db_xref="InterPro:IPR006171" FT /db_xref="InterPro:IPR011557" FT /db_xref="InterPro:IPR013506" FT /db_xref="InterPro:IPR013759" FT /db_xref="InterPro:IPR013760" FT /db_xref="InterPro:IPR014721" FT /db_xref="InterPro:IPR018522" FT /db_xref="InterPro:IPR020568" FT /db_xref="UniProtKB/Swiss-Prot:P05652" FT /protein_id="CAA26221.1" FT /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWEI FT VDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHAGG FT KFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIGETD FT HTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKNEYHY FT EGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNNINTYE FT GGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDPQFEGQT FT KTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKARELTRRK FT SALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPLRGKILNVE FT KARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAHIRTLLLTFF FT YRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTPKPGLQRYKGL FT GEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRNFIEANARYVKN FT LDI" FT repeat_region complement(5860..5868) FT /note="imp. direct repeat 1" FT repeat_region complement(6766..6773) FT /note="imp. direct repeat 1" FT misc_signal 7559..7603 FT /note="put. transcription termination signal (ORF 638)" FT repeat_region 7559..7577 FT /note="imp. inverted repeat C" FT repeat_region 7584..7603 FT /note="imp. inverted repeat C'" FT repeat_region complement(7656..7664) FT /note="direct repeat 1" FT misc_feature 7691..7695 FT /note="pot. transcription initiation region (ORF 821)" FT RBS 7755..7762 FT /note="pot. Shine Dalgarno sequence (ORF 821)" FT CDS 7769..10234 FT /transl_table=11 FT /note="ORF 821 (aa 1-821)" FT /db_xref="GOA:P05653" FT /db_xref="InterPro:IPR002205" FT /db_xref="InterPro:IPR005743" FT /db_xref="InterPro:IPR006691" FT /db_xref="InterPro:IPR013757" FT /db_xref="InterPro:IPR013758" FT /db_xref="InterPro:IPR013760" FT /db_xref="UniProtKB/Swiss-Prot:P05653" FT /protein_id="CAA26222.1" FT /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKPV FT HRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLV FT DGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSR FT FPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAG FT QILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEKIADLV FT RDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALVDG FT QPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDAVISLIRN FT SQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIAELKDIL FT ANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVVTLTHNGYVK FT RLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKVYRAKGYEIPE FT YGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKRTSLSQFANIRN FT NGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMGRTAAGVKGITLT FT DDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKTAKITENNGQLVAV FT KATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEEHVATVALVEKNEED FT ENEEEQEEV" FT repeat_region 8134..8142 FT /note="imp. direct repeat 1" FT repeat_region 10234..10248 FT /note="inverted repeat D" FT repeat_region 10254..10267 FT /note="inverted repeat D'" FT promoter 10280..10285 FT /note="pot. -35 region (16S RNA)" FT promoter 10302..10307 FT /note="pot. -10 region (16S RNA)" FT misc_feature 10315..10315 FT /note="pot. transcription initiation region (16S RNA)" FT promoter 10377..10382 FT /note="pot. -35 region (16S RNA)" FT promoter 10400..10405 FT /note="pot. -10 reion (16S RNA)" FT misc_feature 10412..10412 FT /note="pot. transcription initiation region" FT rRNA 10585..>10664 FT /note="16S RNA" XX SQ Sequence 10664 BP; 3378 A; 2158 C; 2335 G; 2793 T; 0 other; cagctggctc gccggttttc tggcaataat gatgtaatcc ttttccttca gtctctcttt 60 ctcttcaaga aaggcctgcc gaatcaaacg tttgatccga tttcgcatca cagcattgcc 120 aatttttttg ctgacggaaa gcccgacacg cagttcatca ttttcaggct gatcaagcgt 180 atataagaca aactggcggt ttgcaactga tgtcccatgt ttaaacactt tttgaaaatc 240 ttcatttttc tttaaacgat ttcgcttctt caaatgactc actccgatac tggctggcag 300 aaacttttaa aatttattat gaacatgaga tgcatctgaa ccaggaagca tgccccggtt 360 cattacgcat cacatctatc ttttcccata acgtgaaaaa agaccactga cattattcag 420 tggcctaagc tgataatact tttctgcctt tgcggcgacg gcgtgctaaa actagacgac 480 cgttttttga actcatacgg cttctgaagc catgaacttt gctgcgttta cggttattcg 540 gttggaatgt tcttttcatt tatgacacct ccctcgagga atagctgtta aagacagtct 600 tacttattat atttgcgtta cctattcatt gtcaacttca ctagtgcttt tatttcttgc 660 aaccataata ggataccata ccttttcaac tttcgaaacc ttatttttta gattccttaa 720 ttttacggaa aaaagacaaa ttcaaacaat ttgcccctaa aatcacgcat gtggatatct 780 ttttcggctt tttttagtat ccacagaggt tatcgacaac attttcacat taccaacccc 840 tgtggacaag gttttttcaa caggttgtcc gctttgtgga taagattgtg acaaccattg 900 caagctctcg tttattttgg tattatattt gtgttttaac tcttgattac taatcctacc 960 tttcctcttt atccacaaag tgtggataag ttgtggattg atttcacaca gcttgtgtag 1020 aaggttgtcc acaagttgtg aaatttgtcg aaaagctatt tatctactat attatatgtt 1080 ttcaacattt aatgtgtacg aatggtaagc gccatttgct ctttttttgt gttctataac 1140 agagaaagac gccattttct aagaaaagga gggacgtgcc ggaagatgga aaatatatta 1200 gacctgtgga accaagccct tgctcaaatc gaaaaaaagt tgagcaaacc gagttttgag 1260 acttggatga agtcaaccaa agcccactca ctgcaaggcg atacattaac aatcacggct 1320 cccaatgaat ttgccagaga ctggctggag tccagatact tgcatctgat tgcagatact 1380 atatatgaat taaccgggga agaattgagc attaagtttg tcattcctca aaatcaagat 1440 gttgaggact ttatgccgaa accgcaagtc aaaaaagcgg tcaaagaaga tacatctgat 1500 tttcctcaaa atatgctcaa tccaaaatat acttttgata cttttgtcat cggatctgga 1560 aaccgatttg cacatgctgc ttccctcgca gtagcggaag cgcccgcgaa agcttacaac 1620 cctttattta tctatggggg cgtcggctta gggaaaacac acttaatgca tgcgatcggc 1680 cattatgtaa tagatcataa tccttctgcc aaagtggttt atctgtcttc tgagaaattt 1740 acaaacgaat tcatcaactc tatccgagat aataaagccg tcgacttccg caatcgctat 1800 cgaaatgttg atgtgctttt gatagatgat attcaatttt tagcggggaa agaacaaacc 1860 caggaagaat ttttccatac atttaacaca ttacacgaag aaagcaaaca aatcgtcatt 1920 tcaagtgacc ggccgccaaa ggaaattccg acacttgaag acagattgcg ctcacgtttt 1980 gaatggggac ttattacaga tatcacaccg cctgatctag aaacgagaat tgcaatttta 2040 agaaaaaagg ccaaagcaga gggcctcgat attccgaacg aggttatgct ttacatcgcg 2100 aatcaaatcg acagcaatat tcgggaactc gaaggagcat taatcagagt tgtcgcttat 2160 tcatctttaa ttaataaaga tattaatgct gatctggccg ctgaggcgtt gaaagatatt 2220 attccttcct caaaaccgaa agtcattacg ataaaagaaa ttcagagggt agtaggccag 2280 caatttaata ttaaactcga ggatttcaaa gcaaaaaaac ggacaaagtc agtagctttt 2340 ccgcgtcaaa tcgccatgta cttatcaagg gaaatgactg attcctctct tcctaaaatc 2400 ggtgaagagt ttggaggacg tgatcatacg accgttattc atgcgcatga aaaaatttca 2460 aaactgctgg cagatgatga acagcttcag cagcatgtaa aagaaattaa agaacagctt 2520 aaatagcagg accggggatc aatcggggaa agtgtgaata acttttcgga agtcatacac 2580 agtctgtcca catgtggata ggctgtgttt cctgtctttt tcacaactta tccacaaatc 2640 cacaggccct actattactt ctactatttt ttataaatat atatattaat acattatccg 2700 ttaggaggat aaaaatgaaa ttcacgattc aaaaagatcg tcttgttgaa agtgtccaag 2760 atgtattaaa agcagtttca tccagaacca cgattcccat tctgactggt attaaaattg 2820 ttgcatcaga tgatggagta tcctttacag ggagtgactc agatatttct attgaatcct 2880 tcattccaaa agaagaagga gataaagaaa tcgtcactat tgaacagccc ggaagcatcg 2940 ttttacaggc tcgctttttt agtgaaattg taaaaaaatt gccgatggca actgtagaaa 3000 ttgaagtcca aaatcagtat ttgacgatta tccgttctgg taaagctgaa tttaatctaa 3060 acggactgga tgctgatgaa tatccgcact tgccgcagat tgaagagcat catgcgattc 3120 agatcccaac tgatttgtta aaaaatctaa tcagacaaac agtatttgca gtgtccacct 3180 cagaaacacg ccctatcttg acaggtgtaa actggaaagt ggagcaaagt gaattattat 3240 gcactgcaac ggatagccac cgtcttgcat taagaaaggc gaaacttgat attccagaag 3300 acagatctta taacgtcgtg attccgggaa aaagtttaac tgaactcagc aagattttag 3360 atgacaacca ggaacttgta gatatcgtca tcacagaaac ccaagttctg tttaaagcga 3420 aaaacgtctt gttcttctca cggcttctgg acgggaatta tccagacaca accagcctga 3480 ttccgcaaga cagcaaaaca gaaatcattg tgaacacaaa agaattcctt caggccattg 3540 atcgtgcatc tcttttagct agagagggac gcaacaacgt tgtaaaactg tccgcaaaac 3600 cggctgaatc cattgaaatt tcttccaatt cgccagaaat cggtaaagtt gtggaagcaa 3660 ttgttgcgga tcaaattgaa ggtgaggaat taaatatctc ttttagtcca aaatatatgc 3720 tggatgcact aaaggtgctt gaaggagcag aaatacgcgt aagctttaca ggcgcaatga 3780 gacctttctt aattcgcacg ccgaatgatg aaacgattgt acagcttatc cttcctgtca 3840 gaacctatta atccgataca ctgctgccga cccgtcggca gcttttctat tcggtatctg 3900 ctccgacaag ttttcccttt ccctaattcg ttttttttta gtacaattag atattagtga 3960 tatttgaaag aggtcgatat aatggcaaat ccgatttcaa ttgatacaga gatgattaca 4020 ctcggacaat tcttaaaatt agccgatgtg attcagtctg gcggtatggc gaagtggttt 4080 ttaagcgagc atgaagtgct tgtgaacgat gagccggaca accgccgggg cagaaagctg 4140 tatgttggag atgtggtaga gattgaagga tttggttcat ttcaagtcgt caattaaagc 4200 gggtgacact gattgtatat ccagaactta gaactgacat cttaccgcaa ctacgaccat 4260 gctgaacttc aatttgaaaa taaagtaaat gtgatcatcg gagaaaacgc ccaggggaag 4320 acaaacctca tggaggcgat ctatgtcttg tccatggcga aatcgcaccg gacatcaaat 4380 gacaaagaac ttatacggtg ggacaaagac tatgctaaaa tagagggaag agtgatgaag 4440 caaaacgggg cgatcccgat gcagctcgtc atctccaaaa agggtaaaaa gggcaaggtc 4500 aatcatattg aacagcaaaa gctcagccag tatgtcgggg ccctcaacac cattatgttc 4560 gcgccggaag atttaaatct tgtaaaggga agccctcaag tgagaaggcg gtttcttgac 4620 atggaaatcg gacaggtttc tcccgtctac cttcatgatc tttctcttta ccagaaaatc 4680 ctttcccagc ggaatcattt tttgaaacag ctgcaaacaa gaaaacaaac tgaccggacg 4740 atgctcgatg ttctgaccga tcagcttgta gaagttgcag caaaagtcgt cgtaaaacgc 4800 ctgcagttta cagcacagct cgagaaatgg gcgcagccca tccatgcagg catctcaaga 4860 gggcttgaag aactgaccct gaaataccat acagctcttg atgtatcaga tcccctagat 4920 ttgtcgaaaa taggagatag ctatcaagaa gcgttttcta aattaagaga aaaagaaatt 4980 gagcgtggtg tgacgctgtc agggcctcat cgcgatgatg ttcttttcta tgtgaacgga 5040 cgcgatgtgc agacgtatgg ttctcaagga cagcagcgaa cgacggcgtt gtcccttaag 5100 ctggcggaga ttgacctgat ccatgaagaa atcggagaat atcccatttt actattggat 5160 gatgtactga gtgaactgga tgattatcgc cagtcacact tgcttcatac gatccaaggc 5220 cgtgtacaaa cgtttgtcac aacgacaagc gttgatggca ttgatcacga aaccttacgt 5280 caagcaggaa tgttccgtgt gcaaaatggt gcgttagtga agtgaagaaa tgaggtgagc 5340 aattgtatat tcatttaggt gatgactttg tggtttcaac acgagatatt gtcggcattt 5400 ttgactttaa agccaacatg tcgcctattg ttgaagaatt tctgaaaaaa cagaaacaca 5460 aggtggtgcc ttccgtaaac gcacgcccaa atctatcgta gtcacggttc agaatatata 5520 ttactctccc ttatcttcca gcacattaaa aaaacgtgcg caatttatgt ttgaaataga 5580 ttcttagaaa ttttttatca cgaatatatc gtttagaaaa gtgtaggtga atgacgtggc 5640 tatggaacag cagcaaaaca gttatgatga aaatcagata caggtactag aaggattgga 5700 agctgttcgt aaaagaccgg ggatgtatat cggttcgaca aacagcaaag gccttcacca 5760 cttggtatgg gaaattgtcg acaatagtat tgacgaagcc ctcgccggtt attgtacgga 5820 tatcaatatc caaatcgaaa aagacaacag tatcacggtt gtagataatg gccgcggtat 5880 tccagtcggt attcatgaaa aaatgggccg tcctgcggta gaagtcatta tgacggtgct 5940 tcatgccgga ggaaaatttg acggaagcgg ctataaagta tccggaggat tacacggtgt 6000 aggtgcgtcg gtcgtaaacg cactatcaac agagcttgat gtgacggttc accgtgacgg 6060 taaaattcac cgccaaacct ataaacgcgg agttccggtt acagaccttg aaatcattgg 6120 cgaaacggat catacaggaa cgacgacaca ttttgtcccg gaccctgaaa ttttctcaga 6180 aacaaccgag tatgattacg atctgcttgc caaccgcgtg cgtgaattag cctttttaac 6240 aaagggcgta aacatcacga ttgaagataa acgtgaagga caagagcgca aaaatgaata 6300 ccattacgaa ggcggaatta aaagttatgt agagtattta aaccgctcta aagaggttgt 6360 ccatgaagag ccgatttaca ttgaaggcga aaaggacggc attacggttg aagtggcttt 6420 gcaatacaat gacagctaca caagcaacat ttactcgttt acaaacaaca ttaacacgta 6480 cgaaggcggt acccatgaag ctggcttcaa aacgggcctg actcgtgtta tcaacgatta 6540 cgccagaaaa aaagggctta ttaaagaaaa tgatccaaac ctaagcggag atgacgtaag 6600 ggaagggctg acagcgatta tttcaatcaa acaccctgat ccgcagtttg agggccaaac 6660 aaaaacaaag ctgggcaact cagaagcacg gacgatcacc gatacgttat tttctacggc 6720 gatggaaaca tttatgctgg aaaatccaga tgcagccaaa aaaattgtcg ataaaggttt 6780 aatggcggca agagcaagaa tggctgcgaa aaaagcgcgt gaactaacac gccgtaagag 6840 tgctttggaa atttcaaacc tgcccggtaa gttagcggac tgctcttcaa aagatccgag 6900 catctccgag ttatatatcg tagagggtga ctctgccgga ggatctgcta aacaaggacg 6960 cgacagacat ttccaagcca ttttgccgct tagaggtaaa atcctaaacg ttgaaaaggc 7020 cagactggat aaaatccttt ctaacaacga agttcgctct atgatcacag cgctcggcac 7080 aggtatcgga gaagacttca accttgagaa agcccgttac cacaaagttg tcattatgac 7140 agatgccgat gttgacggcg cgcacatcag aacactgctg ttaacgttct tttacagata 7200 tatgcgccaa attatcgaaa atggctacgt gtacattgcg cagccgccgc tctacaaggt 7260 tcaacagggg aaacgcgttg aatatgcata caatgacaag gagcttgaag agctgttaaa 7320 aactcttcct caaacgccta agcctggact gcagcgttac aaaggtcttg gtgaaatgaa 7380 tgccacccag ctatgggaga caaccatgga tcctagctcc agaacacttc ttcaggtaac 7440 tcttgaagat gcaatggatg cggatgagac ttttgaaatg cttatgggcg acaaggtaga 7500 accgcgccga aacttcatag aagcgaatgc gagatacgtt aaaaatcttg acatctaatc 7560 ataaaaagcc ttatttccaa taagaaataa ggcttttttc tgaacaagat cagatgcagc 7620 gatgcctgca atacctatat attctagcaa tttaatgtgt ataatcataa gtttattgat 7680 ataatggaga atagtgaaat cgtattgaag gtcataatgg acaatctact cccacatatt 7740 tcatgtgata cttcagggag gttttttaat gagtgaacaa aacacaccac aagttcgtga 7800 aataaatatc agtcaggaaa tgcgtacgtc cttcttggat tatgcaatga gcgttatcgt 7860 gtcccgtgct cttccggatg ttcgtgacgg tttaaaaccg gttcatagac ggattttgta 7920 tgcaatgaat gatttaggca tgacaagtga caagccttat aaaaaatccg cgcgtatcgt 7980 tggagaagtt atcgggaaat accacccgca cggtgattca gcggtatatg aatccatggt 8040 cagaatggct caggatttca actaccgtta tatgctcgtt gacggtcacg gaaacttcgg 8100 ttctgttgac ggagactcag cggcggccat gcgttataca gaagcacgaa tgtctaaaat 8160 ctcaatggag attcttcgcg acatcacaaa agacacaatc gattaccagg ataactatga 8220 cgggtcagaa agagaacctg tcgttatgcc ttcaaggttc ccgaatctgc tcgtgaacgg 8280 tgctgccggc attgcggtag gtatggcaac aaacattcct ccgcaccagc tgggagaaat 8340 cattgacggt gtacttgctg ttagtgagaa tccggacatt acaattccag agcttatgga 8400 agtcattcca gggcctgatt tcccgaccgc gggtcaaatc ttgggacgca gcggtatccg 8460 gaaagcatac gaatcaggcc gaggctctat cacgatccgg gcaaaagctg agatcgaaca 8520 aacatcttcg ggtaaagaaa gaattatcgt tacagagtta ccttaccaag taaataaggc 8580 gaaattaatt gagaaaattg ctgatctcgt aagggacaaa aagatagagg gtatcacaga 8640 tctgcgtgat gagtcagatc gtacaggtat gagaattgtc attgaaatca gacgcgatgc 8700 caatgcgaat gttatcttaa acaatctgta caaacaaact gctctacaaa catcttttgg 8760 catcaacctg cttgcgcttg ttgatggcca gccgaaagtt ttaactctta agcaatgcct 8820 ggagcattac cttgaccatc aaaaagttgt cattagacgc cgtactgctt atgaattgcg 8880 taaagcagaa gcgagagctc atatcttgga aggattgaga gttgcactgg atcatctcga 8940 tgcagttatc tcccttatcc gtaattctca aacggctgaa attgcgagaa caggtttaat 9000 tgaacaattc tcactgacag agaagcaagc acaagcgatc cttgacatga ggctccagcg 9060 tttaacggga ctggaacgtg aaaagatcga agaagaatac cagtctcttg ttaaattaat 9120 tgcagagcta aaagacatct tggcaaatga atataaagtg cttgagatca ttcgtgaaga 9180 actcacggaa atcaaagagc gttttaacga tgaaagacgt actgagatcg tcacttctgg 9240 actggagaca attgaagatg aagatctcat cgagagagaa aatatcgtag ttactctgac 9300 gcacaacgga tacgtcaaac gtcttcctgc atcaacttac cgcagtcaaa aacggggcgg 9360 aaaaggtgta caaggtatgg gaacaaacga agatgatttc gttgaacatt tgatctctac 9420 gtcaactcat gacacgattc tcttcttctc gaacaagggg aaagtgtatc gtgcaaaagg 9480 gtatgaaatc cctgaatacg gcagaacggc aaaaggaatc ccgattatta acctgctgga 9540 ggtagaaaag ggtgagtgga tcaacgcgat tattccagtc acggaattca atgcggagct 9600 ttacctcttc ttcactacaa agcatggggt ttcaaaacga acatcgctat ctcaattcgc 9660 taatatccgc aacaatggtc taattgctct gagtcttcgt gaagatgatg aactgatggg 9720 tgtacgtctg actgacggca caaaacaaat catcattgga acgaaaaacg gtttactgat 9780 tcgtttccct gaaacagatg tccgagagat gggaagaact gcggcgggcg taaaaggcat 9840 caccctgacg gatgacgacg ttgttgtcgg catggagatt ttagaggaag aatcacacgt 9900 ccttatcgta actgaaaaag ggtacggaaa acgaactcct gctgaagagt acagaaccca 9960 aagccggggc ggaaaaggac tcaaaacagc gaaaatcacc gagaacaacg gccaactagt 10020 agcagtgaaa gctactaaag gtgaagagga tctaatgatt attacagcta gcggcgtact 10080 catcagaatg gacatcaatg atatctccat caccggacgt gtcactcaag gtgtgcgtct 10140 catcagaatg gcagaagaag agcatgttgc tacagtagct ttagttgaga aaaacgaaga 10200 agatgagaat gaagaagaac aagaagaagt gtgaaaaaaa gcgcagctga aatagctgcg 10260 cttttttgtg tcataaccct ttacagtcat aaaaattatg gtataatcat ttctgttgtc 10320 tttttaaaga cacaagcatg accattatga ctagtaaaaa ctttttcaaa aaagtattga 10380 cctagttaac taaaaatgtt actattaagt agtcgctttg agagaagcac acaagttctt 10440 tgaaaactaa acaagacaaa acgtacctgt taattcattt ttataaatcg cacagcgatg 10500 tgcgtagtca gtcaaactag ggcctgcacg acgcaggtca cacaggtgtc gccgcaggat 10560 gcggtgaact taacctgtga tccatttatc ggagagtttg atcctggctc aggacgacgc 10620 tggcggcgtg cctaatacat gcaagtcgag cggacagatg ggag 10664 // |
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