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EBI DbfetchID U95074; SV 1; linear; genomic DNA; STD; INV; 8558 BP. XX AC U95074; XX DT 18-JUL-1997 (Rel. 52, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Caenorhabditis elegans protein disulphide isomerase isoform I (pdi-1) and DE cyclophilin isoform 9 (cyp-9) genes, complete cds. XX KW . XX OS Caenorhabditis elegans OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. XX RN [1] RP 1-8558 RX DOI; 10.1038/368032a0 RX PUBMED; 7906398. RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., RA Dear S., Du Z., Durbin R., Favello A., Fulton L., Gardner A., Green P., RA Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., RA Kirsten J., Laister N., Latreille P., Lightning J., Lloyd C., McMurray A., RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., RA Saunders D., Shownkeen R., Smaldon N., Smith A., Sonnhammer E., Staden R., RA Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., RA Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.; RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. RT elegans"; RL Nature 368(6466):32-38(1994). XX RN [2] RP 1-8558 RX PUBMED; 8694762. RA Page A.P., MacNiven K., Hengartner M.O.; RT "Cloning and biochemical characterization of the cyclophilin homologues RT from the free-living nematode Caenorhabditis elegans"; RL Biochem. J. 317(Pt 1):179-185(1996). XX RN [3] RP 1-8558 RX PUBMED; 8760355. RA Veijola J., Annunen P., Koivunen P., Page A.P., Pihlajaniemi T., RA Kivirikko K.I.; RT "Baculovirus expression of two protein disulphide isomerase isoforms from RT Caenorhabditis elegans and characterization of prolyl 4-hydroxylases RT containing one of these polypeptides as their beta subunit"; RL Biochem. J. 317(Pt 3):721-729(1996). XX RN [4] RP 1-8558 RX DOI; 10.1089/dna.1997.16.1335 RX PUBMED; 9407005. RA Page A.P.; RT "Cyclophilin and protein disulfide isomerase genes are co-transcribed in a RT functionally related manner in Caenorhabditis elegans"; RL DNA Cell Biol. 16(11):1335-1343(1997). XX RN [5] RP 1-8558 RA Page A.P.; RT ; RL Submitted (25-MAR-1997) to the EMBL/GenBank/DDBJ databases. RL Wellcome Unit for Molecular Parasitology, Glasgow University, 56 Dumbarton RL Road, Glasgow, Lanarkshire G11 6NU, Scotland XX FH Key Location/Qualifiers FH FT source 1..8558 FT /organism="Caenorhabditis elegans" FT /chromosome="III" FT /map="III L" FT /mol_type="genomic DNA" FT /db_xref="taxon:6239" FT misc_RNA 4402..4409 FT /note="nematode transpliced leader sequence (SL-1) acceptor FT site" FT mRNA join(4415..4504,4551..4934,4985..5791,5842..6018) FT /gene="pdi-1" FT /product="protein disulphide isomerase isoform I" FT CDS join(4415..4504,4551..4934,4985..5791,5842..6018) FT /codon_start=1 FT /gene="pdi-1" FT /product="protein disulphide isomerase isoform I" FT /function="catalyses the oxidative refolding of reduced FT denatured RNAase" FT /EC_number="5.3.4.1" FT /note="PDI-1; protein disulphide isomerase homolog" FT /db_xref="GOA:Q17967" FT /db_xref="HSSP:1DBY" FT /db_xref="InterPro:IPR012335" FT /db_xref="UniProtKB/Swiss-Prot:Q17967" FT /citation=[3] FT /protein_id="AAB94647.1" FT /translation="MSLSVSFIFLLVASIGAVVADSENVLVLTESNFEETINGNEFVLV FT KFYAPWCVHCKSLAPKYDEAADLLKEEGSDIKLAKVDATENQALASKFEVRGYPTILYF FT KSGKPTKYTGGRATAQIVDWVKKKSGPTVTTVESVEQLEELKGKTRVVVLGYFKDAKSD FT AATIYNEVADSVDDAFFAVAGSAEVAAAASLNEDGVALIRTDGDDSETSTIAEAEITNT FT IALKQWLHAYKLSAVTEFTHESAQEIVGGDLKKFHFLIIRKSDSSFDETIAKFTEVAKK FT FRAKIVFVLLDVDVEENARILEFLGVDAKNTPANRIVSLADQVEKFKPQEGEDFEAFTN FT SYLEGKSAQDLKAQDLPEDWNALPVKVLVASNFNEIALDETKTVFVKFYAPWCGHCKQL FT VPVWDELAEKYESNPNVVIAKLDATLNELADVKVNSFPTLKLWPAGSSTPVDYDGDRNL FT EKFEEFVNKYAGSASESETASQDHEEL" FT polyA_signal 6111..6116 FT /gene="pdi-1" FT misc_RNA 6223..6230 FT /note="nematode transpliced leader sequence (SL-2) acceptor FT site" FT mRNA join(6237..6324,6376..6503,6549..6752,7150..7473, FT 7739..7876,7927..7974) FT /gene="cyp-9" FT /product="cyclophilin isoform 9" FT CDS join(6237..6324,6376..6503,6549..6752,7150..7473, FT 7739..7876,7927..7974) FT /codon_start=1 FT /gene="cyp-9" FT /product="cyclophilin isoform 9" FT /function="catalyses the cis-trans isomerasation of a FT synthetic Ala-Pro peptide" FT /EC_number="5.2.1.8" FT /note="CYP-9; cyclophilin homolog; peptidyl prolyl FT cis-trans isomerase (PPI)" FT /db_xref="GOA:Q09637" FT /db_xref="HSSP:1A58" FT /db_xref="InterPro:IPR002130" FT /db_xref="UniProtKB/Swiss-Prot:Q09637" FT /citation=[2] FT /protein_id="AAB94648.1" FT /translation="MAAEKRVFLDISVDENLIGRIEIRLFVEDAPKTCENFRALCTGEV FT GMTPNNKARLHYKQNEFHRIVKKFMIQGGDITEGDGRGGFSIYGRYFDDEKFKLKHSRP FT YLLSMANKGPNSNSSQFFITTAAAPHCNGKHVVFGEVVKGQNVVDYIDNLAVDDKSKPL FT AKVLISNCGELVKKKKPLKTDEELAAALEEKNNNARDNEIPKCPKSWLYRDDDNEKKHE FT MRNDKRREYRSRRSRSRSHEKNRDYKKENRGDSSRSQPRRDENGITVRGRGGVRFRRER FT SATPEHWRRNAPTKWVHDSHKHPEEDLV" FT polyA_signal 8058..8063 FT /gene="cyp-9" XX SQ Sequence 8558 BP; 2578 A; 1672 C; 1625 G; 2683 T; 0 other; aatttcgaag attttcagtg ttttgtcgtc ggaagcagag acaacacaac ggctgtcgga 60 actccatgct atatcgttta cacccagttt gtggccggtg agctgaaaat ttaaggatta 120 attgtaattt tcatgagcgg aaacatacag ttcgctcaca aatcatgtga tccatgttcc 180 agattttgac ggttttgtcc gcgctgcttg ttccgagata ctttccacat ggggaaaatt 240 tagctgaaga aatcgatttt gtgtgtcctt ccaatgtaca catcagctta taatttgctg 300 aacccgaggc tgaagctccg gcggcgtttg gattgggagt ttgggcactg gcacctggag 360 cgggtgtgcc agtcggattt gatggcgaaa ttgaattggg agaagtctgg aaattgacta 420 ttgtgaagtc ttattcaaaa atatactatt taacaataac gaaacctaca gatggagcag 480 gagctgaaga acctccatcc ggagcatttg gtactgttaa ttgatcgatt tgttgtgttg 540 gctgttgctc ggcagctgaa gcagcatttt cgctggtatc catatctgaa atcacagcaa 600 aaatcaaaaa ttaagttgaa aaatgaagaa attcattcaa aaaatataaa atagaaatcg 660 tcgtaagatg caatgtgcgg tacgcagagg caagggtgca tgcacagcga acacacaatt 720 tgacgcgcaa tgtttttgca gttttttttt cggaatttct tttttttcgt taatgaactc 780 atgtcatgac atgtatccgt gtctgatacg tgttaaaata tttatatatt cattcgatta 840 cagatataac aaacttttcc agtcatacaa acactttata aaacagttaa gcgaaaaatt 900 gtcggtgcat tatttaatct tcctcgtctt catcttcatg acgagccaca gcgggaggaa 960 ttccatacat gtgacgacca cgacgaaaga gtggcattct aaaaactccg actcttggcg 1020 gtacttcatc atcgtcatca tcctcgtctt cagcgttagg attctcgtct tcattgcatt 1080 tttcggaatc aacagcgagt ggtttaacta ttggctcatc aggcagaata acttcgactt 1140 gaatattggc aacttttggt ccgtagaatc ctctccaaaa ttgtctatct tcaccttcat 1200 tcagaatagt taaatgtcga attccagacg ggtaatcgtc aaactcaatt gtccaatctt 1260 cccaaggttg accagtccat tgagcccatt ccttatttac agatttatat cttttatgat 1320 cagtgttgct catagtttgt acatggccaa atctttcaat ccactgagtc tcgtgatagt 1380 tcaactgagc agcaaatgag agcctggctg cacaatcatt acgatgattg actttctgtg 1440 taattctaat tctcgggcga acgtgatcca agatccatgg gtcaattcca gagttcacca 1500 aatcgatgaa aacactgatt gagctctctg tgaatgaaaa tacgaagcac ttggaaacat 1560 ccggatgtgg ttcacaaccg tttcctccat ctctttccat gtggattctg aaattgtaaa 1620 tattgattat tttaagaaca aagtattgac atacccactg ccattcgctc tgattgaaaa 1680 atcatctgaa cggagagttc cacttattgt gttgtcacgt gcattttcaa aatgagaaat 1740 gaaaagcgga gtgattggtg agtagcctct tccagacaga acctgaagta aaactttgta 1800 attttattac tataaaatgc gataacctac tattttttta atattaaaat taaaacttga 1860 agtgtcaatt tcattgtctt catttccaac aaacttcttc tgtgtcgctg ctcttctcca 1920 ctccaaagat ggaagaacat ttgatatatt taaaattcga gcatattcaa tccaaaacga 1980 gtcacttgat atcaaatcat tgaatcgatg gcaagccaat tggcagttta gaagtgattt 2040 tttgtccagc cttcggaaaa ttggcgagaa acattcgttc ggcacagttt ctgcatctct 2100 gaaataattc taggtgaaaa attgatattt taattaagaa aaaactcaca ttatcactgg 2160 aacatcggtt ttgaactgta gactttgcat tatcgatgag aacgctttaa acatttgggg 2220 tcgatgagaa caatattttt cgattttaaa gagaagaaat gagtcagaag gagagagacg 2280 cagagaatgg aagtcttgcg aaatgcgcat gcatgtgata ttcgtgttcc aaaaaactat 2340 cacgctgtta atattattat tttaaagcaa aaatattaat aagaaaatat tcaatgctat 2400 tttgagaatg agaaaaaaac tttctgacaa aaatattgag aacctctaga tattcaactt 2460 ctttatatat tttatttttt tcctcatctt gctgactgca actttttaga ttagttgata 2520 tatatttgtc tttctcttct cttagtttta caggttacga aacattgatg atcttcctta 2580 tccaaagata cgtggacagc aagaaataac ttgtcccact ttctaggtta tcgccgccaa 2640 taccaaggtc aagcaattca tgttcttcag atttgtgttt ctaaaaagga aaaaaaaacg 2700 aataaccgtg tttatgaaga aatactcgtg caataggaac ctgtcaaatt ggaatagatt 2760 agtgatgcta tttacaaaaa ttttgaacat gaattagaac tagtgattat catcaaattc 2820 cgtggataaa tcactgcgga gatcagggtt cggaatggcg atttgctcat cctctcggac 2880 ttccaaagcc atctcgaaat cttcatcttg aacgggacct cttggaatct ctcttgttgc 2940 aatactggtc aatgggacat tatagtcggg ggaatcgtag gcaacgtgtg aactgaaggt 3000 gttccgtttc ttgcgctcag tttttccttc gctcagtgac atgagtgcct aaaaattcaa 3060 ttatctagct ttaatcttta gtgtaatcat tttttaccag cttaatcgtg atgaaaacgt 3120 aaatcagagc aacgagaatg atgttgagat agactgcaaa ccaaatcctt gtcgcctcat 3180 ccttcttcag atttgtcatc aagccgtccg acgatctgcg cgacgtggcc taaaaacggt 3240 tgtgtcaata tgacccctcc caccgtcgat gttatatact tactgtactc tttccgaaaa 3300 gacctgtcac agagtcaaac attcctcttg ttttctcagc tgccgtattc aaccacgacg 3360 gcacctccac gcgttgaccg aacaattcga tactattatc ctttaatatt tatgtgtttt 3420 gatatatcct cattttgagc ccaccttcga acgtaatcct tctgccatcg agtcttcagt 3480 ctggtttctc acatagaaac attgaattga aacaaccagc aacaggatta gtgggatttt 3540 catagcggaa acctgaatat aatgtaatat gtatgtgaca aaatcacgaa agaaaaaaga 3600 atttccaaaa aaaaatgaaa ttagaaatca ttgaaacaag tatttgattg tccactcgga 3660 ctacactgta tacagcgctt cgagaccata tctttaaatc cggtgcgtct ttaaaagagt 3720 gattatttga cccagttttt aaagtcattt tttgagctaa ttttagttcc aaaaacaact 3780 tttttgataa acttgcccat tccgaataaa ttttttgggt tcagaataat tttaagttga 3840 agataagcat aattatattc gaatagactc tcatttccgg gccgtcgacg ttcctttagc 3900 attgtagttg cacaaacttt cagttcgatg tgttttgttc attttctcac tgttttaagg 3960 tttagaacac aattaatttt ccattaaatg cgcgaactct catctcaata agtcataaag 4020 gtcgccacgg tgacgtccac gtggacatct cccgtacacg cgtatgctga cgtgtcaata 4080 ctgcactgtc cattcgtctt gcagtttcgc ggtcctcgtt gtctctgccg gggcgttcac 4140 ggtctcttct ctttctctcg ttactctgtt ttacaacgtg cgcttattct ccttctcttc 4200 tcgtcgctcg cactcttcct agcaggttgt gaacgacgag gattttttaa aagaaaaatt 4260 gactgcgttt gtcaatactc ataccctact tttttgatcg caaagtaatg gctaacgtat 4320 tgtttgcaca cttatcgttg tctatacctc ttttctcttc aatgataact tcctcaaatt 4380 ttctattact atttttttaa attttcaggt aattatgtca ctgtcagtgt cctttatctt 4440 cctcctggtc gcatcaatcg gagcagttgt tgctgacagc gaaaacgtgc ttgttctcac 4500 tgaagtataa catttattct gatcattatc ttctaaaaaa ctgttttcag agcaatttcg 4560 aagaaactat caatggaaat gagtttgttc tagtcaaatt ctatgctcca tggtgtgtac 4620 attgcaagtc tcttgctcca aagtacgacg aagccgccga tttgctgaag gaggaaggat 4680 ccgatatcaa gctcgccaag gttgacgcca ccgaaaacca agctcttgca tccaagttcg 4740 aggtccgtgg atatccaact atcctctact tcaagagtgg aaagccaacg aaatacaccg 4800 gaggacgcgc caccgctcaa attgtcgatt gggtcaagaa gaagagtgga ccaactgtta 4860 ccactgttga gtcagttgag caactcgagg aattgaaggg aaagaccaga gttgttgttc 4920 ttggatactt caaggtattt ttttacataa aaagtacaac ctatttaatt tatttatttt 4980 tcaggacgcg aaatctgatg ctgctaccat ctacaacgaa gttgctgatt ctgtcgatga 5040 cgcattcttc gccgttgccg gttctgctga ggttgctgct gccgcatctt tgaatgaaga 5100 tggagtcgct cttatccgca ctgatggaga cgacagcgag actagcacaa ttgctgaagc 5160 tgaaatcacc aacaccatcg ctcttaagca atggctccac gcttacaagc tctctgccgt 5220 gaccgagttc acccacgaat ctgctcaaga aatcgtcgga ggagacctca aaaagttcca 5280 ctttttgatc atccgcaagt cagactcttc tttcgatgag actattgcca agttcactga 5340 ggtcgctaag aagttccgtg ctaagatcgt ctttgttctt ctcgacgttg atgttgaaga 5400 gaacgcaaga attctcgagt tcctcggagt cgatgccaag aacaccccag ccaacagaat 5460 tgtcagcctt gccgatcaag ttgagaagtt caagccacaa gaaggagaag atttcgaagc 5520 tttcaccaac tcatatttgg aaggaaagtc tgctcaagac ttgaaggctc aagatcttcc 5580 agaagattgg aatgcactcc cagttaaggt tctcgtcgcc tccaacttca acgaaattgc 5640 ccttgatgaa accaagactg tcttcgtcaa attctacgcc ccatggtgcg gacattgcaa 5700 gcaactggtt ccagtttggg atgagcttgc tgagaagtac gagtccaacc caaatgttgt 5760 cattgcaaag cttgatgcta ctctcaacga ggtaagaatt ttgaaagtat caatattcat 5820 aattattatt tccattttca gcttgccgac gtcaaggtca actctttccc aaccctgaag 5880 ctgtggccag ccggatcttc taccccagtc gactatgatg gagacagaaa cctcgagaag 5940 ttcgaagaat ttgtcaacaa gtatgctgga tctgcttccg aatctgaaac cgcatctcag 6000 gatcacgaag agctttaaat taataatata tatgttattt attgtttgaa gtcacggcgt 6060 tgaattgtga ttactcgttt ttttttgttt ccatccgtat atattatata tataaaaccc 6120 taaaaattga atcccggaga atgttttttg tttcgttgag gcttctgtga aattatattt 6180 ctttatttcg gaatttaaaa tttcgaatcg aaaccaaaac cattttcagg ctgcgaatgg 6240 ccgctgaaaa aagagtgttc ctagatattt cagtcgatga gaatctgatt ggaagaattg 6300 aaatacgact ttttgtcgaa gatggttaga aatctgccca gaaaattaat ttaaaaaaaa 6360 tcaattattt ttcagcacct aaaacatgtg aaaactttcg agcattgtgc acaggagaag 6420 tcggaatgac tccaaataat aaagcacggc ttcattacaa acaaaacgaa tttcatagaa 6480 ttgtaaagaa gtttatgatc caggtccggc ggtttttagc tgaaattttt gaaaaattga 6540 cgatttaggg aggagacatc acagaaggag atggtagagg aggattctcg atctacggac 6600 gatactttga cgatgaaaag ttcaaattaa agcactcaag gccctatttg ttgtcaatgg 6660 ccaataaagg accaaattca aattcttctc aatttttcat cacaacggct gcagctccac 6720 attgcaatgg aaaacatgtt gtttttggag aggtgcataa tggattttaa agaatatatt 6780 aattttataa ttataaaatc atgatttcac gagattctaa cataaaggcg cagagattta 6840 ttcagatggg tctcggcgcg aaagacagtt tatggtagtc atttttgaag ttttgcgtct 6900 gttttcactt tgttaaaaat tgtttttcag ttttaaaata aaaagtaatg ttttgttcat 6960 aaaatcattt ttacagggaa aaccgattta aaacgatttc aaaataacag aaaaatgaac 7020 aaaaaaacca actactataa atttttagca cgccgagacc catctcttta aagccgtgcg 7080 cctttaagtc aaaatctgtt gaaattacga tacttttata ctttaatgtt aaaataaatt 7140 gaattccagg ttgtcaaagg acaaaacgtt gtagattaca tcgacaatct tgcggttgat 7200 gataaatcga aaccactcgc aaaagttttg atctccaatt gtggagaact cgtgaaaaag 7260 aagaaaccat tgaagacaga tgaagagctc gccgctgctc tcgaagagaa aaataataac 7320 gcaagggaca atgagatccc gaaatgcccg aaatcttggc tctatcgtga tgatgacaat 7380 gagaagaagc atgaaatgag aaatgataag agaagagagt atcgatcgag aagatcaaga 7440 tctagatctc atgagaagaa tcgcgactat aaggtttatt ttgtaatgaa aaattcggtt 7500 ccaggtctcg ccacgaaaag aaccaaatat tttcgaatca atcgatcaag aattgaattt 7560 cgctgatttt tcgattttta atggaaaaaa tttgcaaaaa aaaaagttta cttgattgga 7620 gaaatctaat ttttagcatc ttcctgtcat ttctccattt tccaccaaaa ttaattcccg 7680 attttttgaa actattttaa agttaaattt cttaatttct taaactagat tttttcagaa 7740 agaaaatcga ggagattctt cgcgaagcca acctcgcaga gatgaaaacg gaattactgt 7800 acgtgggcgt ggaggagtac gcttccgacg cgaaagatct gcgactccgg agcactggag 7860 aagaaatgcg ccgacggtat tttaaatctg aataattata atttttaaat tgaatttttg 7920 tttcagaaat gggttcacga cagccacaaa catccagaag aagatctcgt ttaaatcttt 7980 tttttaaaat taatttaatt aattcgttgt ttttatttcc agctcggtgc aatacaaatt 8040 ttttagttta ttatttttat aaatagaaga agaaacaacg gaaaacacgc atttcttgtg 8100 gcagtcttcc ggtttctctt ctcagatttg tacctgacac ggataccttt gatctctctc 8160 tctctcacct cactcgttga ataatttgtg agaacctggc atattctttt gtcgggggct 8220 cagagacaac tcctcctact cgagaagctt cgaaaagaga gaacaaagac taaaaaatcg 8280 ttatgcttga tttgattccg gtactcccac tggttttgtt tggagtttct ttattttttt 8340 cgaaaattgg ttgaactttt tttttcaact ttcttacaaa aaatattttt tgagtttaga 8400 aaactaaaaa aaaggttttt ttctgttttc aggtacgttt tctggaaatt tctagcgtta 8460 ttcttggcct cacggcctcc accacgagaa atgcgcacac tctctcgctt tttgtttgcg 8520 cgtttgcgga cgaccacctt gcctcgccgc cgctttca 8558 // |
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