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EBI DbfetchID U84349; SV 1; linear; genomic DNA; STD; PRO; 5722 BP. XX AC U84349; XX DT 12-MAR-1997 (Rel. 51, Created) DT 18-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Amycolatopsis orientalis hypothetical hydroxylases a and b genes, partial DE cds, glycosyltransferases GtfA (gtfA), GtfB (gtfB) and GtfC (gtfC) genes, DE complete cds. XX KW . XX OS Amycolatopsis orientalis OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis. XX RN [1] RP 1-5722 RA Solenberg P.J., Matsushima P., Stack D.R., Wilkie S.C., Thompson R.C., RA Baltz R.H.; RT "Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces RT toyocaensis"; RL Unpublished. XX RN [2] RP 1-5722 RA Solenberg P.J.; RT ; RL Submitted (08-JAN-1997) to the EMBL/GenBank/DDBJ databases. RL Lilly Research Labs, Lilly Corporate Center, Indianapolis, IN 46285, USA XX FH Key Location/Qualifiers FH FT source 1..5722 FT /organism="Amycolatopsis orientalis" FT /strain="A82846" FT /mol_type="genomic DNA" FT /db_xref="taxon:31958" FT CDS <1..1133 FT /codon_start=3 FT /transl_table=11 FT /product="hypothetical hydroxylase a" FT /db_xref="InterPro:IPR006905" FT /db_xref="UniProtKB/TrEMBL:Q79BA3" FT /protein_id="AAB49291.1" FT /translation="ILLNNAKRKGVVVREGSPVTDVVEDGERVTGLRYTDADGNEREVS FT ARFVIDASGNKSRLYSKVGGSRNYSEFFRSLALFGYFEGGKRLPAPVSGNILSVAFDSG FT WFWYIPLSDTLTSVGAVVRREDAEKIQGDREKALNALIAECPLISEYLANATRVTTGKY FT GELRVRKDYSYQQETYWRPGMILIGDAACFVDPVFSSGVHLATYSALLAARSINSVLAG FT DLDEKTALNEFEMRYRREYGVFYEFLVSFYQMNVNEESYFWQAKKVTQNQSTDIESFVE FT LIGGVSSGETALTAADRIAARSAEFAAAVDQMASGDGDNMVPMFKSTVVKQAMQEAGQV FT QMKALLGEDAEPELPLFPGGLVTSPDGMKWLPHHPA" FT CDS 1178..2368 FT /codon_start=1 FT /transl_table=11 FT /gene="gtfA" FT /product="glycosyltransferase GtfA" FT /function="involved in biosynthesis of glycopeptide FT antibiotic A82846" FT /db_xref="GOA:P96558" FT /db_xref="InterPro:IPR004276" FT /db_xref="PDB:1PN3" FT /db_xref="UniProtKB/TrEMBL:P96558" FT /protein_id="AAB49292.1" FT /translation="MRVLITGCGSRGDTEPLVALAARLRELGADARMCLPPDYVERCAE FT VGVPMVPVGRAVRAGAREPGELPPGAAEVVTEVVAEWFDKVPAAIEGCDAVVTTGLLPA FT AVAVRSMAEKLGIPYRYTVLSPDHLPSEQSQAERDMYNQGADRLFGDAVNSHRASIGLP FT PVEHLYDYGYTDQPWLAADPVLSPLRPTDLGTVQTGAWILPDERPLSAELEAFLAAGST FT PVYVGFGSSSRPATADAAKMAIKAVRASGRRIVLSRGWADLVLPDDGADCFVVGEVNLQ FT ELFGRVAAAIHHDSAGTTLLAMRAGIPQIVVRRVVDNVVEQAYHADRVAELGVGVAVDG FT PVPTIDSLSAALDTALAPEIRARATTVADTIRADGTTVAAQLLFDAVSLEKPTVPA" FT CDS 2403..3626 FT /codon_start=1 FT /transl_table=11 FT /gene="gtfB" FT /product="glycosyltransferase GtfB" FT /function="involved in biosynthesis of glycopeptide FT antibiotic A82846" FT /db_xref="GOA:P96559" FT /db_xref="InterPro:IPR004276" FT /db_xref="PDB:1IIR" FT /db_xref="UniProtKB/TrEMBL:P96559" FT /protein_id="AAB49293.1" FT /translation="MRVLLATCGSRGDTEPLVALAVRVRDLGADVRMCAPPDCAERLAE FT VGVPHVPVGPSARAPIQRAKPLTAEDVRRFTTEAIATQFDEIPAAAEGCAAVVTTGLLA FT AAIGVRSVAEKLGIPYFYAFHCPSYVPSPYYPPPPLGEPSTQDTIDIPAQWERNNQSAY FT QRYGGLLNSHRDAIGLPPVEDIFTFGYTDHPWVAADPVLAPLQPTDLDAVQTGAWILPD FT ERPLSPELAAFLDAGPPPVYLGFGSLGAPADAVRVAIDAIRAHGRRVILSRGWADLVLP FT DDGADCFAIGEVNHQVLFGRVAAVIHHGGAGTTHVAARAGAPQILLPQMADQPYYAGRV FT AELGVGVAHDGPIPTFDSLSAALATALTPETHARATAVAGTIRTDGAAVAARLLLDAVS FT REKPTVSA" FT CDS 3775..5004 FT /codon_start=1 FT /transl_table=11 FT /gene="gtfC" FT /product="glycosyltransferase GtfC" FT /function="involved in biosynthesis of glycopeptide FT antibiotic A82846" FT /db_xref="GOA:P96560" FT /db_xref="HSSP:1IIR" FT /db_xref="InterPro:IPR004276" FT /db_xref="UniProtKB/TrEMBL:P96560" FT /protein_id="AAB49294.1" FT /translation="MRVLLSTAGSRGDVEPLVALAVRLQGLGVEARMCASPASAERLAE FT VGVPHVPVGLQLEGMLLQEGMPPPSPEEERRLAAKAIDMQFDEVPAAAEGCAAVVAAGE FT LAAAAAVRSVAEMLGIPYFYAAYSPNYLPSPHHAPPEDERTTPGVTDNKVLWDERGQRF FT AKRYGDTLNSRRASVGLPPVEDVFGYGYSERPWLATDPILAPLPPDFDAVQTGTWILPD FT ERPLSAELEAFLAAGSPPVYLGFGSASGPGIDDAARVAIEAIRAHGRRIVLLSGWADLV FT RPDDGADCFSVDEVNLQVLFSRAAAAIHHGSAGTEHLATLAGIPQIVIPRHTDQPYYAE FT RVADLGIGVALEGPVPTFDAMSAAVATALAPETRARATAVAGTIRTDGAAVAARLLLDA FT VSREKSAVLA" FT CDS 5077..>5722 FT /codon_start=1 FT /transl_table=11 FT /product="hypothetical hydroxylase b" FT /db_xref="InterPro:IPR013630" FT /db_xref="UniProtKB/TrEMBL:Q79BA2" FT /protein_id="AAB49295.1" FT /translation="MSVTSQCRICDGTVKEFIDFGRQPLSDAFVVPGDEKGEFFFRLAT FT GICDSCTMVQLMEEVPRDLMFHDAYPYLSSGSAFMRTHFNELAKRLLTTELTGEDPFIV FT ELGCNDGIMLKAMAEAGVRQLGVEPSGSVADLAAAKGIRVRKDFFEEATAADIRETDGP FT ADVIYAANTLCHIPYMDSILKGVTTLLGPNGVFVFEDPYLGDIVERTSFDQI" XX SQ Sequence 5722 BP; 900 A; 1852 C; 2022 G; 948 T; 0 other; agatcttgct gaacaacgcc aagcgcaagg gcgtggtcgt gcgggaaggg tccccggtca 60 ccgatgtggt ggaagacggt gagcgggtca ccggtctgcg gtacaccgac gccgatggca 120 acgagcgtga agtgtcagcg cgcttcgtga tcgacgcgtc gggcaacaag agccgcctct 180 actccaaggt cggcggttcg cggaactact cggagttctt ccgcagcctc gcgctgttcg 240 gctacttcga gggtggcaag cggctgcccg cgccggtctc gggaaacatc ctgagcgttg 300 ccttcgacag cggctggttc tggtacatcc cgctgagcga cacgctgacc agcgtcggcg 360 cggtggtgcg ccgggaggac gccgagaaga tccagggtga ccgggagaag gcgctcaacg 420 ccctgatcgc cgagtgcccg ctgatctcgg agtacctcgc gaacgcgacc agggtgacga 480 ccggcaagta cggggagtta cgcgtccgca aggactactc ctaccagcag gagacctact 540 ggcggccggg gatgatcctg atcggcgacg ccgcgtgctt cgtggacccg gtgttctcgt 600 ccggtgtgca cctggcgacc tacagcgcgc tgctcgcggc ccggtcaatc aacagcgtcc 660 tggcgggcga tctggacgag aagaccgcac tgaacgagtt cgaaatgcgg tatcgccgcg 720 agtacggggt gttctacgag ttcctcgtgt cgttctatca gatgaacgtg aatgaggagt 780 cgtatttctg gcaggccaag aaggtcacgc agaaccagag caccgatatc gagtcgttcg 840 tcgaactgat cggtggggtg tcgtccggtg agaccgcgct gacggccgct gaccggatcg 900 ccgcgcgcag tgccgaattc gccgcggccg tggaccagat ggccagcggc gacggcgaca 960 acatggtgcc gatgttcaag tcgacggtgg tcaagcaggc gatgcaggaa gcgggccagg 1020 tccagatgaa ggcgctgctc ggcgaggacg ccgaacccga gctgccgctg ttccccggcg 1080 gcctggtgac ctcgcccgac ggaatgaaat ggctgccgca ccatccggca tgagcctccg 1140 cacggtggtc gaggatctac gaaatagggg atgcgaaatg cgcgtgttga ttacggggtg 1200 tggatcgcgc ggagataccg aaccgttggt ggcattggcg gcacggttgc gggaactcgg 1260 tgcggacgcg cggatgtgcc tgccgccgga ctacgtggag cggtgcgccg aggtcggtgt 1320 gccgatggtg ccggtcggtc gggcggtgcg cgcaggggca cgcgagccgg gagaactgcc 1380 gccgggggcg gccgaagtcg tgaccgaggt ggtcgccgaa tggttcgaca aggtcccggc 1440 ggccatcgag gggtgtgacg cggtggtgac gaccggcttg ctgcccgccg cggtcgctgt 1500 ccggtcgatg gccgagaagc tgggcatccc gtaccgctac accgtgctgt ctccggacca 1560 tctgccgtcg gagcaaagcc aggcggagcg ggacatgtac aaccagggcg ccgacaggct 1620 tttcggtgac gcggtcaaca gccaccgggc ctcgatcggc ctgccaccgg tggagcacct 1680 ctacgactac ggctacaccg atcagccctg gctggcggcg gacccggtgc tgtccccgct 1740 gcggccgacg gacctcggca ctgtgcagac cggtgcgtgg atcctgcccg acgaacggcc 1800 gctttccgcg gagctggagg cgtttctggc tgccgggtcg acgccggtgt acgtgggttt 1860 cggcagctcg tcccgaccgg caaccgctga cgccgcgaag atggccatca aggcggtccg 1920 tgccagtggc cgccggatcg ttctctcccg cggctgggcc gatttggtcc tgccggacga 1980 cggggccgac tgcttcgtgg tcggcgaagt gaaccttcag gagctgttcg gccgggtggc 2040 cgccgccatc caccacgaca gcgcgggcac gacgctgctg gccatgcggg cgggcatccc 2100 ccagatcgtg gtgcgccgcg tagtggacaa cgtggtggag caggcgtacc acgccgaccg 2160 ggtggccgag ctgggtgtcg gtgtggcggt cgacggtccg gtcccgacca tcgactcctt 2220 gtcggccgcg ctcgacacgg ctctggcccc ggagatccgt gcgcgagcga cgaccgtggc 2280 agacacgatt cgcgccgatg ggacaacggt ggccgcgcag ctgctgttcg acgcggtcag 2340 cctggaaaag ccgactgttc ccgcctgaac cacaccgagc ctatggaacg aggaaattcg 2400 taatgcgtgt gctgttggcg acgtgtggat cgcgcggaga taccgaaccg ctggtggcac 2460 tggcggttcg ggtgcgggac ctcggcgcgg atgtgcggat gtgcgcaccg ccggactgcg 2520 cggagcggct ggccgaggta ggtgtgccgc atgtgcccgt cggcccgtcg gcgcgcgcgc 2580 cgatccagcg agcgaaaccg ttgacggccg aggacgtgcg ccggttcacg accgaggcga 2640 tcgctacgca gttcgacgag atcccggcgg cggccgaggg gtgtgccgcg gtggtgacca 2700 ccggcctgct ggccgccgcg atcggcgtgc ggtcggtggc cgagaagctg ggcatcccct 2760 acttctatgc cttccactgt ccgagttatg tgccgtcgcc gtactatccg ccgccgcccc 2820 tcggcgaacc gtccacacag gacacgatcg acattccggc gcagtgggag cggaacaacc 2880 agagcgccta ccagcggtac ggcggcctgc tcaacagcca ccgggacgcg atcggcctgc 2940 caccggtgga ggacatcttc accttcggct acaccgatca cccctgggtg gcggcggatc 3000 cggtgctggc cccgctgcag ccgacagacc tcgacgccgt gcagaccggc gcgtggatcc 3060 tgcccgacga acggccgctt tccccggagc tggcggcgtt tctggacgcc ggcccaccgc 3120 cggtgtacct ggggttcggc agcctgggcg cacctgctga cgcggtccgg gtggccatcg 3180 acgcgatccg tgcccatggc cgccgggtga tcctttcccg tggctgggcc gatttggtcc 3240 tgcccgacga cggtgccgac tgcttcgcga tcggcgaagt gaaccatcag gtgctgttcg 3300 gccgagtcgc cgccgtcatc caccacggcg gcgcgggcac gacgcacgtg gccgcgcggg 3360 caggtgcacc ccagatcctg ttgccccaga tggcggacca gccgtactac gccggccggg 3420 tggccgaact gggtgttggt gtggcacatg atggtccaat tccgaccttc gattccttgt 3480 cggccgcgct tgccacggct ctgacccccg aaacccacgc gcgagcgacg gccgtggcag 3540 gcacgatccg caccgacggg gcagcggtgg ccgcgcggtt gctgctcgac gcggtcagtc 3600 gggaaaagcc gactgtttcc gcgtaaacca caccgagccg gcgccttgag aatcggcgcg 3660 tgggtgacct cgacattgtc catcgtgtga tctttctgga cataaatgcc tcgccgtaac 3720 atgccgatta attgtcggca tgtggccaga acctatcaaa ataggggatg cgaaatgcgt 3780 gtgttgttgt cgacggctgg cagccgcgga gacgtcgaac cgctggtggc attggcggtt 3840 cggctgcagg ggctcggcgt ggaggcacgg atgtgcgcat cgccggcctc cgcggagcgg 3900 ctggccgagg taggtgtgcc gcacgtgccg gtcggcctgc agctggaggg catgctgttg 3960 caggagggga tgccgccgcc gtcgcccgag gaggagcgcc ggctcgcggc caaggcgatc 4020 gacatgcagt tcgacgaggt ccccgcggct gccgaagggt gtgccgcggt ggtggcggcc 4080 ggcgagctgg ccgccgcggc cgccgtgcgg tcggtggccg agatgctggg cattccctac 4140 ttctacgccg cctacagtcc gaactatctg ccgtcgccgc accacgcgcc gcccgaggac 4200 gagcggacca cgccgggcgt gaccgacaac aaggtgctgt gggacgagcg tggccagcgt 4260 tttgccaagc ggtacgggga cacgctcaac agcaggcggg cctcggtcgg cctgccaccg 4320 gttgaggacg tcttcggcta cggctactcc gagcggccct ggctggcgac ggacccgatc 4380 ctggccccgc tgccgccgga tttcgacgcc gtgcagaccg gtacgtggat cctgccggac 4440 gaacggccgc tttccgcgga gctggaggcg tttctggctg ccgggtcacc gccggtgtac 4500 ctggggttcg gcagcgcgtc cggacctggc atcgatgacg ccgcgagggt ggccatcgag 4560 gcgatccgtg cccatggccg ccggatcgtc ctgctcagcg gctgggccga cctggtccgg 4620 cccgacgacg gggcggactg cttctccgtc gacgaagtga atcttcaggt cctgttcagc 4680 cgggcggccg ccgccatcca ccacggcagc gcgggcaccg agcacctggc cacgctggcc 4740 ggcatcccgc agatcgtgat tcctcggcac acggaccagc cgtactacgc cgaacgagtg 4800 gctgacctgg gtatcggcgt ggcactcgag ggtccggtcc cgaccttcga cgcgatgtcg 4860 gccgcggtcg ccacggccct tgccccggaa acccgcgcgc gtgcgacggc cgtggcaggc 4920 acgatccgca ccgacggggc agcggtggcc gcgcggttgc tgctcgacgc ggtcagccgg 4980 gaaaagtcgg ctgttctcgc gtaatccacg tgcccgaccg ttcttcgatc ggtatttctc 5040 ccacaatttc gtcgacgaca agcacaagga gactgcatgt cggtcacgtc ccagtgccgt 5100 atctgtgacg gcactgtcaa agagttcatc gatttcggac gccagccgct ctcagacgcg 5160 ttcgtcgttc ccggcgatga gaagggtgag ttcttcttcc ggctcgccac cgggatttgc 5220 gattcctgca cgatggtgca gctgatggaa gaagtcccgc gggacctgat gttccacgac 5280 gcgtatccct atctgtcgtc cggttcggcg ttcatgcgca cgcatttcaa cgagttggcc 5340 aagcgcttgc tgaccacgga gctgaccggc gaggacccgt tcatcgtcga gctcggctgc 5400 aacgacggca tcatgctcaa ggccatggcc gaagcgggtg tgcgccagct cggcgtcgaa 5460 ccctccggca gcgtcgcgga tctggccgcg gccaagggaa tccgcgtccg caaggacttc 5520 ttcgaagagg cgacggcagc cgacatccgc gagaccgacg gccccgccga cgtgatctac 5580 gcggccaaca ccctgtgcca catcccttac atggactcga tcctgaaggg cgtcaccacg 5640 ctgctgggcc cgaatggcgt gttcgtcttc gaggacccgt acctcggtga catcgtggag 5700 cgcacgtcgt tcgaccagat ct 5722 // |
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