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EBI DbfetchID U66560; SV 1; linear; genomic DNA; STD; PRO; 7853 BP. XX AC U66560; XX DT 29-OCT-1996 (Rel. 49, Created) DT 08-NOV-1996 (Rel. 49, Last updated, Version 3) XX DE Mycobacterium avium EmbR (embR), EmbA (embA) and EmbB (embB) genes, DE complete cds. XX KW . XX OS Mycobacterium avium OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium avium complex (MAC). XX RN [1] RP 1-7853 RX DOI; 10.1073/pnas.93.21.11919 RX PUBMED; 8876238. RA Belanger A.E., Besra G.S., Ford M.E., Mikusova K., Belisle J.T., RA Brennan P.J., Inamine J.M.; RT "The embAB genes of Mycobacterium avium encode an arabinosyl transferase RT involved in cell wall arabinan biosynthesis that is the target for the RT antimycobacterial drug ethambutol"; RL Proc. Natl. Acad. Sci. U.S.A. 93(21):11919-11924(1996). XX RN [2] RP 1-7853 RA Belanger A.E., Inamine J.M.; RT ; RL Submitted (09-AUG-1996) to the EMBL/GenBank/DDBJ databases. RL Microbiology, Colorado State University, Center Street, Fort Collins, CO RL 80523-1677, USA XX FH Key Location/Qualifiers FH FT source 1..7853 FT /organism="Mycobacterium avium" FT /strain="2151" FT /mol_type="genomic DNA" FT /db_xref="taxon:1764" FT CDS complement(1..1155) FT /codon_start=1 FT /transl_table=11 FT /gene="embR" FT /product="EmbR" FT /function="regulator" FT /note="ethambutol target" FT /db_xref="GOA:P71484" FT /db_xref="InterPro:IPR001969" FT /db_xref="UniProtKB/TrEMBL:P71484" FT /protein_id="AAC44546.1" FT /translation="MANAGLGFGVLGPLSVTAGGAQLPLGAPKQRAVLAMLLIHRNRPV FT SVDALIDGVWGAAPVPAARTSIQSYVSTLRRLLRSALPNPNGLLASVPPGYQLNVADAD FT CDLGRFRGHKTAGVQAASRGRFEEASGHLAAALREWRGPVLDDLHNFAFVDAFANLLLE FT ERVAAHTARAEAEIACGRADGVIGELEALVAQHPYREPLWAQLITAYYVTERQSDALGA FT YRRLKTALAEGLGIDPGPTVKALQQRILRQEPLGPGQPGKAARRAMLSTHKQSTVRSES FT AAAVVDNPVVARLRDKAGRHYQLNGVTTRIGRLDDNEIVLDDTEVSRHHAVIIDTGTDF FT LITDMKSTNGVQVRGRRVQRSATLVDGDHIRIGNSEFVFEIRPA" FT promoter 1156..1332 FT /gene="embAB" FT /note="divergent" FT CDS 1333..4659 FT /codon_start=1 FT /transl_table=11 FT /gene="embA" FT /product="EmbA" FT /function="arabinosyl transferase" FT /note="ethambutol target" FT /db_xref="GOA:P71485" FT /db_xref="InterPro:IPR007680" FT /db_xref="UniProtKB/Swiss-Prot:P71485" FT /protein_id="AAC44547.1" FT /translation="MPHDGKQRSQRIPRSVAAVAGIAGLLLCLAVPLLPVRQTTATVLW FT PQGTVDGHVSQITAPLVSGAPRALDISIPCPAVATLPADGGLVVSTLPPGGMDAGKNGL FT FVRANKDVVVVAFRDTVAAVAQRPAVAAGACSVLHAWADAGAAGAEFVGIPGAAGTLPA FT EKKPQVGGIFTDLKVPAGPGLSARVDIDTRFITAPTVLKQIVMVLGTLAVLTAIVALAV FT LDRRSRGGGTLINWRSPIAWLSRYRPGTHLANWRRVGLATWIADAAVLATLLLWHVVGA FT TSSDDGYNLTIARVAPKAGYLVDYYRYFGTTDAPFDWYLGLLSRLASVSTAGVWMRLPA FT TLAGIGCWLIISHWVLRRLGPGRGGLAANRVAVFTAGAVFVAAWLPFNNGLRPEPLIAL FT GVLVTWMLVERAIALQRLAPAAVAVVVALLTATLAPQGLIAVAALLTGARAVAQAIRRR FT RASDGLLAPLAVLAAALSLILVVVFRSQTVATVLESARIKYKVGPTIAWYQDWLRYYFL FT TVESNPDGSMARRFAVLVMLLCLFGMLVILLRRGHVPGVASGPRWRLIGTTAVGLLLLT FT FTPTKWAVQFGAFAGLAGALGALTAFACSRIGLHNRRNLTLYVTALLFVLAWATSGING FT WFYVGNYGVPWYDIQPVIASHPVTSMFLTLSIITGLLAAWQHFRMDYAGHTEVKDSRRN FT RVLASTPLLVVATIMVVGEVASLTKGAVFRYPLYTTGKANLAAIASGLSPTSCAMADDV FT LAEPDANAGMLQPLPGQTFGPDGPLGGVNPVGFKPDGVGDDLQSDPVVTKPGLVNSDAS FT PNKPNVAYSDSAGTAGGKGPVGVNGSHAALPFGLDPARTPVMGSYGENSLAATATSAWY FT QLPPRTPDRPLVVVSAAGAIWSYKEDGTFTYGQSLKLQWGVARPDGSTVPLAEVQPIDI FT GPQPAWRNLRFPLAWAPPEANVARIVAYDPNLSSEQWFAFTPPRVPVTETLQQLIGSQT FT PVMMDIATAANFPCQRPFSEHLGVAELPAYRILPDRKQTAASSNLWQSSEAGGPFLFLQ FT ALLRTSTIPTYLRGDWYRDWGSVEQYFRLVPADQAPDAAIEQGVMTVHGWSRQGPIRAL FT P" FT CDS 4656..7853 FT /codon_start=1 FT /transl_table=11 FT /gene="embB" FT /product="EmbB" FT /function="arabinosyl transferase" FT /note="ethambutol target" FT /db_xref="GOA:P71486" FT /db_xref="InterPro:IPR007680" FT /db_xref="UniProtKB/Swiss-Prot:P71486" FT /protein_id="AAC44548.1" FT /translation="MSVSTVGGDVRVTRWVATIAGLIGFVLSVATPLLPVVQTTATLNW FT PQGGQLNSVTAPLISLTPVDLTATVPCSLVRDLPPGGGVILSTGPKKGKDAALNALFVV FT AHGKRVDVTDRNVVIASASRDQVAGAGCSRIEIASTRAGTFATFVGLTDPAGKPLGGGF FT PDPNLRPQIVGVFTDLTGPAPAGLKLSATIDTRFSTTPTTLKLAAMVTAILATIVALVA FT LWRLDQLDGHRMRRLIPANWRTFTLADVAVIFGFVLWHVIGANSSDDGYILGMARVADR FT AGYMSNYFRWFGSPEDPFGWYYNLLALMTHVSDASLWMRLPDLFAGIVCWLLLSREVLP FT RLGPAVAASRPANWAAGMVLLTAWMPFDNGLRPEPIIALGSLVTYVLIERSMRYSRLTP FT AALAVITAAFTLGVQPTGLIAVAALVAGGRPILRILVRRHRVVGTWPLVAPMLAAGTVI FT LTVVFADQTLATVLEATRIRTAIGPSQAWYTENLRYYYLILPTVDGSLSRRFGFLITAL FT CLFTAVFIMLRRKRIPGVARGPAWRLMGVIFGTMFFLMFTPTKWVHHFGLFAAVGAAMA FT ALTTVLVSPAVLGWSRNRMAFLAALLFMMALCFATTNGWWYVSSYGVPFNSTMPKIGGI FT TVSTVFFSMFVAAALYAIWLHFASREHGEGRLARALTAAPVPLAAGFMALVFIASMVAG FT IVRQYPTYSNAWDNLREFSGGCGLADDVLVEPDSNVGYMTPLGGDYGPLGPLGGQHPVG FT FSPNGVPEHTVAEAIRITPNQPGTDYDWDAPTKLSAPGINGSTVPLPYGLDAARVPLAG FT SYTTGAQQQSRLTSAWYRLPAPDDGHPLVVVTAAGKIAGNSVLHHHTDGQTVVLEYGRP FT GPGGDIVPAGRLVPYDLYGEQPKAWRNLRFARSDMPADTVAVRVVAEDLSLTPEDWIAV FT TPPRVPEMRSLQEYVGSTQPVLMDWAVGLAFPCQQPMLHVNGVTEIPKFRITPDYTAKK FT MDTDTWEDGTNGGLLGITDLLLRAHVMSTYLSHDWGRDWGSLRRFETIADAHPAQLDLG FT TATRTGWWSPGPIRIKP" XX SQ Sequence 7853 BP; 1037 A; 2827 C; 2753 G; 1236 T; 0 other; tcaggcgggc cggatttcga agacgaactc ggagttgccg atgcggatgt ggtcaccgtc 60 gaccagggtg gcgctgcgct gcacccgccg gccccgcacc tggacgccgt tggtcgattt 120 catgtcggtg atcaggaaat ccgttccggt gtcgatgatg acggcatggt ggcggctgac 180 ctcggtgtcg tccagcacga tctcgttgtc gtcgagccgg ccgatccggg tggtcacccc 240 gttgagctga tagtggcgcc cggccttgtc ccgcaaccgg gcgacgacgg gattgtcgac 300 caccgccgcc gccgactcgg accgcaccgt gctctgcttg tgggtgctca gcatcgcccg 360 cctggcggcc ttcccgggct ggccgggccc gagcggctcc tggcgcagga tgcgctgctg 420 cagcgccttg acggtgggcc ccgggtcgat gcccagcccc tcggccagcg cggtcttgag 480 ccgccggtag gcgccgagcg catcggattg gcgttcggtg acgtagtagg cggtgatcag 540 ttgcgcccac agcggttcgc ggtagggatg ctgggcgacc agcgcctcga gctccccgat 600 cacgccatcg gcgcgcccgc aggcgatctc ggcctcggcg cgggcggtgt gcgccgcgac 660 gcgctcctcg agcagcaggt tggcgaacgc gtcgacgaac gcgaagttgt ggagatcgtc 720 gagcaccggt ccgcgccatt cgcgcagcgc cgccgccagg tggccgctgg cctcctcgaa 780 gcgtccccgg ctggcggcct gcacccccgc ggtcttgtgc ccgcggaagc gtcccaggtc 840 gcagtccgcg tcggcgacgt tgagctggta gccgggcggg acactggcca gcaacccgtt 900 ggggttgggc aacgcgctgc gcagcagccg gcgcagggtg gacacatagg actggatgct 960 ggtgcgcgcc gccggcaccg gcgccgcgcc ccacaccccg tcgatcaacg cgtcgacgga 1020 caccggccgg ttgcggtgga tcagcagcat ggccagcacc gcccgctgtt tgggcgcacc 1080 caacggcagc tgggcgccgc cggcggtcac cgacaacgga cccaggacac cgaaccccag 1140 acctgcgttc gccacgcgct gtcagcctcc tcagcagtcc attttgaccg cacgcacgcg 1200 gcgaatgctg aattggcggg cggatgttcg ctgtgaatca cccccgggtt cgcaccggcg 1260 cgcggcggag atcgcccccg cgcagccccg catcccgggc ggacaaagcc gcgtcgctta 1320 cgatcgagcc tcgtgcccca cgacggtaaa cagcgatcgc agcggatccc ccggtcggtg 1380 gccgccgtcg cgggcatcgc cggcctgctg ctgtgcctgg ccgtcccgct gctcccggtg 1440 cgccagacca cggccaccgt gctgtggccg cagggcacgg tcgacggaca cgtcagccag 1500 atcaccgcgc ccctggtgtc gggggcgccc cgcgcgctgg acatctccat cccctgcccg 1560 gccgtcgcca ccctgcccgc cgacggcggc ctggtggtct ccacgctgcc gcccggcggc 1620 atggacgccg gcaagaacgg gctgttcgtg cgggccaaca aggacgtggt cgtcgtcgcc 1680 ttccgggaca ccgtcgcggc ggtggcgcag cgcccggccg tcgccgccgg ggcctgcagc 1740 gtgctgcacg cctgggccga cgccggcgcg gccggtgccg agttcgtcgg catccccggc 1800 gccgcgggaa ccctgcccgc cgagaagaag ccccaggtcg gcgggatctt caccgacctc 1860 aaggtgcccg ccgggccggg gctttcggcc cgcgtcgaca tcgacacccg gttcatcacc 1920 gcgccgacgg tcctcaaaca gatcgtgatg gtgctgggca cgctggcggt gctgaccgcc 1980 atcgtcgcgc tggcggtgct ggaccggcgc agccgcggcg gcggcaccct gatcaactgg 2040 cgctccccga tcgcgtggct gtcccggtac cgccccggca cccacctggc caactggcgc 2100 cgggtcgggc tcgcgacctg gatcgccgac gccgcggtgc tcgccaccct gctgctgtgg 2160 cacgtcgtcg gggcgacctc gtcggacgac ggctacaacc tgaccatcgc ccgggtcgcg 2220 ccgaaggccg gctacctcgt cgactactac cgctacttcg gcaccaccga cgcgcccttc 2280 gactggtatc tgggcctgct gtcccggctg gcctcggtga gcacggccgg cgtgtggatg 2340 cggctgcccg cgacgctggc cgggatcggc tgctggctga tcatcagcca ctgggtgctg 2400 cgccggctgg gcccgggccg gggcgggctg gcggccaacc gggtggcggt cttcaccgcg 2460 ggcgcggtgt tcgtcgcggc ctggctgccg ttcaacaacg ggctgcggcc cgaaccgctg 2520 atcgcgctgg gcgtgctggt cacctggatg ctggtggaac gggccatcgc gctgcagcgg 2580 ctggcgccgg cggcggtggc cgtcgtggtg gcgttgctga ccgccaccct ggcgccgcag 2640 ggcctgatcg cggtcgccgc gctgctcacc ggcgcccggg ccgtcgccca ggccatccgg 2700 cggcgccggg ccagcgacgg tctgctggcg ccgctggcgg tgctggcggc ggcgctgtcg 2760 ctgatcctgg tggtggtgtt ccgcagccag accgtggcca cggtgctgga gtcggcccgg 2820 atcaaataca aggtcggccc gacgatcgcc tggtaccagg attggttgcg ctactacttc 2880 ctgacggtcg agtccaaccc cgacgggtcg atggcgcggc gcttcgccgt gctggtgatg 2940 ctgctgtgcc tgttcggcat gctggtcatc ctgctgcgcc gcggccatgt ccccggggtg 3000 gccagcggcc cgcgctggcg gctgatcggc accaccgccg tcggcctgct gctgttgacg 3060 ttcacgccga ccaagtgggc ggtccagttc ggcgccttcg ccgggctggc cggggcgctg 3120 ggcgcgctga ccgcgttcgc ctgctcgcgg atcggcctgc acaaccgccg caatctcacg 3180 ctgtacgtga cggcgttgct gttcgtgctg gcctgggcca cctccgggat caacggctgg 3240 ttctacgtcg gcaactacgg ggtgccgtgg tacgacatcc agccggtcat cgccagccac 3300 ccggtgacgt cgatgttcct gacgctgtcc atcatcaccg ggctgctggc ggcctggcag 3360 cacttccgga tggactatgc gggccacacc gaggtcaagg acagccggcg caaccgcgtg 3420 ctggcgtcca ccccgctgct ggtggtcgcg accatcatgg tggtcggcga ggtcgcctcg 3480 ctgaccaagg gcgcggtgtt ccgctacccg ctgtacacca ccggcaaggc caacctggcc 3540 gccatcgcgt cggggctgtc gccgaccagc tgcgcgatgg ccgacgacgt gctggccgag 3600 ccggacgcca acgccggcat gctgcagccg ctgccgggcc agacgttcgg gccggacggg 3660 ccgctcggcg gggtcaaccc ggtcggcttc aaacccgacg gcgtgggcga cgacctgcag 3720 tccgaccccg tggtgaccaa gcccgggctg gtcaactcgg acgcctcccc caacaaaccc 3780 aacgtcgcct acagcgactc ggcgggcacc gccggcggca aggggccggt gggcgtcaac 3840 ggctcgcacg cggcgctccc gttcggcctc gacccggccc gcaccccggt gatgggcagc 3900 tacggcgaga actcgctggc cgccacggcc acctcggcct ggtaccagct gccgccccgc 3960 acgccggacc gcccgctggt ggtggtgtcg gcggccggcg cgatctggtc ctacaaggag 4020 gacggcacgt tcacctacgg ccagtcgctg aaactgcagt ggggcgtggc ccgcccggac 4080 ggcagcacgg tgccgctggc tgaggtgcag ccgatcgaca tcggcccgca gccggcgtgg 4140 cgcaatctgc gcttcccgct ggcctgggcg ccgccggagg ccaacgtggc gcgcatcgtc 4200 gcctacgacc cgaacctgag ttccgagcag tggttcgcgt tcaccccgcc gcgggtgccg 4260 gtgaccgaaa ccctgcagca gctgatcggc tcgcagacgc cggtgatgat ggacatcgcg 4320 accgcggcga acttcccgtg ccagcggccc ttctccgaac accttggcgt ggctgaactt 4380 ccggcctacc gcatcctgcc ggaccgcaag cagaccgcgg cgtcgtcgaa cctgtggcag 4440 tccagcgaag ccggcgggcc gttcctgttc ctgcaggcgc tgctgcgcac ctcgaccatc 4500 ccgacctatc tgcgcggcga ctggtatcgc gactggggat cggtggagca gtacttccgg 4560 ttggtgccgg ccgatcaggc gccggacgcc gctatcgaac agggtgtgat gacagtgcac 4620 ggctggagcc ggcagggacc gattcgggca ctcccatgag cgtttcgacc gtcggcggcg 4680 acgtgcgggt gacgcgctgg gtggcgacca tcgccgggct gatcgggttc gtgctgtcgg 4740 tcgccacccc gctgctgccc gtcgtgcaga ccaccgcgac gctgaactgg ccgcagggcg 4800 gtcagttgaa cagcgttacc gcaccgctga tttcgctcac cccggtggac ctgaccgcga 4860 cggtgccctg ctcgttggtg cgcgacctgc cgcccggggg cggggtgatc ctgtccaccg 4920 ggcccaagaa gggcaaggac gccgcgctca acgcgttgtt cgtcgtcgcc cacggcaagc 4980 gcgtcgacgt caccgaccgc aacgtggtga tcgccagcgc atcccgggat caggtggccg 5040 gagccgggtg ttcccgcatc gagatcgcct cgacccgcgc cggcaccttc gccaccttcg 5100 tcgggctcac cgacccggcg ggcaaaccac tcggcggcgg attccccgac cccaacctgc 5160 ggccccagat cgtcggcgtg ttcaccgacc tgaccgggcc cgccccggcc ggcctgaagc 5220 tgtcggcgac catcgacacc cgattctcca ccacgccaac cactttgaag ctggcggcga 5280 tggtgacggc gatcctggcc accatcgtcg cgctggtcgc gctgtggcgg ctcgaccagc 5340 tggacgggca ccggatgcgc cggctcattc cggcgaactg gcgcacgttc accctggccg 5400 acgtcgcggt gatcttcggg ttcgtgctct ggcacgtgat cggggcgaac tcgtcggacg 5460 acggctacat cctgggcatg gcccgggtgg ccgaccgcgc cggctacatg tcgaactact 5520 tccgctggtt cggcagcccc gaggatccgt tcggctggta ctacaacctg ctggcgctga 5580 tgacgcatgt cagcgacgcc agcctgtgga tgcggttgcc ggacctgttc gccggaatcg 5640 tgtgctggct gttgctgtcc cgcgaggtgc tgccccggct gggaccggcg gtggccgcca 5700 gcaggccggc caactgggcg gcgggcatgg tgttgctgac ggcgtggatg ccgttcgaca 5760 acgggctgcg ccccgagccg atcatcgcgc tgggatcgct ggtcacctat gtgctgatcg 5820 agcgttcgat gcgctacagc cggctcaccc cggccgcgct ggccgtcatc acggccgcct 5880 tcacgctggg cgtgcagccc accggcctga tcgcggtggc cgcgttggtc gccggtggtc 5940 gcccgatcct gcgcatcctg gtccgccggc accgggtggt gggcacctgg ccgctggtgg 6000 cgcccatgct ggccgccggc acggtgatcc tgacggtggt gttcgccgac cagacgctgg 6060 caacggtgtt ggaagccacc aggattcgca ccgcgatcgg acccagccag gcctggtaca 6120 ccgagaacct gcgctactac tacttgatcc tgcccaccgt cgacggctcg ctgtcccggc 6180 ggttcggctt cctgatcacc gcgctgtgcc tgttcaccgc ggtgttcatc atgttgcggc 6240 gcaagcgaat tcccggggtg gcccgcgggc cggcgtggcg gctgatgggt gtcatcttcg 6300 gcaccatgtt ctttttgatg ttcaccccca ccaagtgggt gcaccatttc ggcctgttcg 6360 ccgcggtggg ggcggcgatg gccgcgctga ccaccgtgct ggtgtcgccg gcggtgctcg 6420 gctggtcgcg caaccggatg gcgttcttgg ccgcgctgct gttcatgatg gcgctgtgct 6480 tcgccaccac caacggctgg tggtatgtgt ccagctacgg ggtgccgttc aacagcacca 6540 tgccgaagat cggcggaatc acggtcagca cagtcttttt ctcgatgttc gtcgcggccg 6600 cgctgtacgc gatctggttg cacttcgcct cccgggagca cggcgagggc cggctggccc 6660 gggcgctgac ggcggcgccg gtgcccctcg cggccggctt catggcgctg gtgttcatcg 6720 cgtcgatggt ggccggcatc gtccgccagt accccaccta ctccaacgcc tgggacaacc 6780 tgcgcgagtt cagcggcggc tgcggactgg ccgacgacgt gctcgtcgaa ccggacagca 6840 acgtcggcta catgacgccg ctcggcggcg attacgggcc gctgggcccg ctgggcggcc 6900 agcacccggt gggcttctcc ccgaacgggg tgcccgaaca cactgtcgcc gaagcgattc 6960 ggatcacccc caaccagccc ggcaccgact acgactggga cgcgccgacc aagctgagcg 7020 cgccgggcat caacggctcg accgtgccgc tgccgtacgg cctggacgcc gcccgggtgc 7080 cgctggccgg cagctacacc accggggcgc aacagcagag ccggctgacc tcggcgtggt 7140 accggctgcc cgcacccgat gacggtcacc cgctggtggt ggtgaccgcc gctggcaaga 7200 tcgccggcaa cagcgtgctg caccaccaca ccgacgggca gaccgtggtg ctcgagtacg 7260 gccggcccgg gcccggcggt gacatcgtgc ccgccggccg gctggtgccc tacgacctgt 7320 acggcgagca gcccaaggcc tggcgcaacc tgcgcttcgc ccgctccgac atgcccgcgg 7380 acaccgtggc cgtgcgggtg gtggccgagg acctgtcgct gacgccggag gactggatcg 7440 cggtgacccc gccgcgggtg cccgagatgc gctcgctgca ggagtacgtc ggctcgaccc 7500 agccggtgct gatggactgg gcggtggggc tggccttccc ctgccagcag ccgatgctgc 7560 acgtcaacgg ggtcaccgag atccccaagt tccgcatcac cccggattac accgccaaga 7620 agatggacac cgacacctgg gaggacggca ccaacggggg cctgctgggg atcaccgacc 7680 tgctgctgcg ggcgcacgtg atgtcgacgt acctgtcgca cgactggggc cgggactggg 7740 gatcgttgcg ccggttcgaa acgatcgccg atgcgcatcc cgcgcaactc gatctgggca 7800 ccgcgacccg caccggttgg tggtcgccgg gcccgatacg aataaaacca taa 7853 // |
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