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EBI DbfetchID U63094; SV 1; linear; genomic RNA; STD; VRL; 6842 BP. XX AC U63094; XX DT 26-MAR-1997 (Rel. 51, Created) DT 28-SEP-2002 (Rel. 73, Last updated, Version 3) XX DE Lassa virus L protein gene, complete cds. XX KW . XX OS Lassa virus OC Viruses; ssRNA negative-strand viruses; Arenaviridae; Arenavirus; OC Old world arenaviruses. XX RN [1] RP 1-6842 RX PUBMED; 9049403. RA Lukashevich I.S., Djavani M., Shapiro K., Sanchez A., Ravkov E., RA Nichol S.T., Salvato M.S.; RT "The Lassa fever virus L gene: nucleotide sequence, comparison, and RT precipitation of a predicted 250 kDa protein with monospecific antiserum"; RL J. Gen. Virol. 78(Pt 3):547-551(1997). XX RN [2] RP 1-6842 RA Lukashevich I., Djavani M., Shapiro K., Sanchez A., Ravkov E., Nichol S., RA Salvato M.S.; RT ; RL Submitted (05-JUL-1996) to the EMBL/GenBank/DDBJ databases. RL Pathology and Laboratory Medicine, University of Wisconsin, 1300 University RL Avenue, Madison, WI 53706, USA XX FH Key Location/Qualifiers FH FT source 1..6842 FT /organism="Lassa virus" FT /strain="Josiah" FT /mol_type="genomic RNA" FT /db_xref="taxon:11620" FT CDS 158..6814 FT /codon_start=1 FT /product="L protein" FT /function="polymerase" FT /db_xref="GOA:O09705" FT /db_xref="InterPro:IPR010453" FT /db_xref="UniProtKB/Swiss-Prot:O09705" FT /protein_id="AAB50401.1" FT /translation="MEEDIACVKDLVSKYLVDNERLSRQKLAFLVQTEPRMLLMEGLKL FT LSLCIEVDSCNANGCEHNSEDKSVERILHDHGILTPSLCLWYPDGYKLTGNVLILLECF FT VRSSPANFEQKYIEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNEQIPDWVNDKLRDT FT LFSLLKYAQESNSLFEESEYSRLCESLFMTSGRLSGVESLNVLMDNRSNHYEEVIASCH FT QGINNKLTAHEVKLQIEEEYQVFRNRLRKGEIEGQFLKVDKSQLLNELNNLYADKVVAE FT DNIEHLIYQFKRASPILRFLYANVDEGNEKRGNQTIGECQVQCWRSFLNKVKSLRILNT FT RRKLLLIFDALILLASKHDLMKQKCLKGWLGSCFLRVKDRLVSLEATKRDLEKWGERGN FT RLRSRITQSSQCLSKNQILNSIFQKTILKATTALKDVGISVDHYKIDMEVICLNSYDLI FT MDFDVSGVVPTISYQRTEEETFPYVMGDVELLGTTDLERLSSLSLALVNSMKTSSTVKL FT RQNEFGPARYQVVRCKEAYCQEFSLGNTELQLIYQKTGECSKCYAINDNKVGEVCSFYA FT DPKRYFPAIFSAEVLQTTISTMISWIEDCNELEGQLNNIRSLTKMILVLILAHPSKRSQ FT KLLQNLRYFVMAYLSDYHHKDLIDKIREELITDVEFLLYRLIRTLMNLVLSEDVKSMMT FT NRFKFILNVSYMCHFITKETPDRLTDQIKCFEKFLEPKVRFGHVSTNPADTATEEELDD FT MVYNAKKFLSKDGCTTIEGPDYKRPGVSKKYLSLLTSSFNNGSLFKEREVKREIKDPLI FT TSGSAALDLASKKSVVVNKYTDGSRILNYDFNKLTALAVSQLTEVFSRKGKYLLNKQDY FT EYKVQQAMSNLVLGSGQLKSDADGADLDEILLDGGASDYFDQLKETVEKIVDQYREPVK FT LGSGPNGDGQPSINDLDEIVSNKFYIRLIKGELSNHMVEEFDHDILPGKFYEEFCNAVY FT ENSRLKQKYFYCGHMSQCPIGELTKAVSTRTYFNHEYFQCFKSILLIMNANTLMGRYTH FT YKSRNLNFKFDMGKLSDDVRISERESNSEALSKALSLTNCTTAMLKNLCFYSQESPQSY FT DSVGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEAISLQLSGSCLNNE FT KEFENAILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLTVLQNLIFLSKDLQADIKGRD FT YLSTLLMWHMHKMVEIPFNVVTAMMKSFIKAQLGLRKKTKQSITEDFFYSNFQAGVVPS FT HISSILDMGQGILHNTSDFYALISERFINYAISCICGGTIDAYTSSDDQISLFDQSLTE FT LLQRDPEEFRTLIEFHYYMSDQLNKFVSPKSVIGRFVAEFKSRFFVWGDEVPLLTKFVA FT AALHNIKCKEPHQLAETIDTIIDQSVANGVPVHLCNLIQKRTLNPLQYARYPIDPFLLN FT CETDVRDWVDGNRSYRIMRQIEGLIPNACSKIRSMLRKLYNRLKTGQLHEEFTTNYLSS FT EHLSSLRNLCELLDVEPPSESDLEYSWLNLAAHHPLRMVLRQKIIYSGAVNLDDEKIPT FT IVKTIQNKLSSTFTRGAQKLLSEAINKSAFQSSIASGFVGLCRTLGSKCVRGPNKENLY FT IKSIQSLISDVKGIKLLTNSNGIQYWQVPLELRNGSGGESVVSYFRPLLWDYMCISLST FT AIELGAWVLGEPKTVKVFDFFKHNPCDYFPLKPTASKLLEDRVGLNHIIHSLRRLYPSV FT FEKHILPFMSDLASTKMKWSPRIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSS FT ELRLSHSRTHEPMVEERVVSTSDAVDNFMRQIYFESYVRPFVATTRTLGSFTWFPHKTS FT VPEGEGLHRMGPFSSFVEKVIHKGVERPMFKHDLMMGYAWIDFDIEPARFNQNQLIASG FT LVDPKFDSLEDFFDAVASLPPGSAKLSQTVRFRVKSQDASFKESFAIHLEYTGSMNQQA FT KYLVHDVTVMYSGAVSPCVLSDCWRLVLSGPTFKGKSAWYVDTEIINEFLIDTNQLGHV FT TPVEIVVDMERLQFTEYDFVLVGPCTEPTPLVVHRGGLWECGKKLASFTPVIQDQDLEI FT FVREVGDTSSDLLIGALSDMMIDRLGLRMQWSGVDIVSTLRAAAPSCEGILSAVLEAVD FT NWVEFKGYALCYSKSRGKVMVQSSGGKLRLKGRTCEELTRKDECIEDIE" XX SQ Sequence 6842 BP; 2104 A; 1163 C; 1578 G; 1997 T; 0 other; cgcaccgagg atcctaggca ttaaggctat cttatttaat tgtctttaat tgcctcttgt 60 gtcttctgtg cccctacggg accctatccc atagcgaact gttgctctag cagaccacat 120 gttctgaggg ttctgaacat catacctgca gctaaacatg gaggaagaca tagcctgtgt 180 caaagactta gtatcaaaat acctagtgga caacgagaga ttgtcaagac agaagttagc 240 atttcttgtg cagacagagc ctaggatgct attaatggaa gggttgaaac tcttgtccct 300 ctgtattgag gttgattctt gcaacgcaaa tggttgcgag cataacagtg aggacaaatc 360 tgtggaaaga attctccatg accatggaat cttgacacct tcactatgtt tgtggtaccc 420 ggacggttac aaactgacgg gcaatgttct aatactgctg gagtgttttg ttagatcatc 480 tcctgctaac tttgagcaga agtacattga ggacttcaaa aaattagagc agctgaaaga 540 agacctgaag agtgtcgaca tcaatttaat accacttata gacgggagaa catcattcta 600 caatgaacaa atacctgact gggtcaatga taagttgagg gatacgctct tctcactttt 660 aaagtatgca caggagagta attcactttt tgaagagtca gagtatagca gactctgtga 720 atctttattc atgacttcgg gtagattatc aggggtggag agtttaaatg ttctgatgga 780 caatcgctct aatcattatg aggaagtgat tgcctcatgc caccagggca tcaataataa 840 attaacagct catgaggtaa agctgcagat cgaagaggag tatcaagtgt ttaggaacag 900 attgaggaaa ggagagatag aaggtcagtt tttaaaggtt gataagagcc agttacttaa 960 tgagcttaac aatttgtacg ctgataaggt agttgcagaa gacaatatcg aacacttaat 1020 ttaccagttc aagagagcat caccaatatt gagatttttg tatgcaaatg ttgatgaggg 1080 gaatgaaaaa aggggaaacc aaactattgg agaatgtcag gttcaatgct ggagatcatt 1140 cctaaataaa gtaaaatctt tgaggatatt gaacacaagg aggaaacttc tattaatttt 1200 tgatgcacta attctccttg caagtaagca tgacctgatg aaacaaaagt gtttaaaagg 1260 gtggttgggg tcttgcttct taagagttaa agatagacta gtttctttgg aggcaacaaa 1320 gagggatctc gagaaatggg gagagcgagg caacaggcta agatctagaa tcacacagtc 1380 ctcccagtgt ttgagtaaga atcaaatcct caattcaata ttccagaaaa ccattttgaa 1440 ggccaccact gctttaaagg atgttgggat cagtgtggac cactataaaa ttgatatgga 1500 ggtgatctgc cttaacagct atgatttgat tatggacttt gatgtctccg gagttgtccc 1560 aacaatcagt tatcagagaa cagaggaaga aacattccct tatgtgatgg gggatgtgga 1620 actactggga accactgact tagagagact ttcctcattg agcctcgctt tggtgaactc 1680 tatgaaaact tcttctaccg taaagctgag acagaatgaa tttggacccg caaggtatca 1740 agtggtcaga tgcaaagaag catattgtca agagttttca ttgggtaaca ctgaattaca 1800 actgatttat caaaagacag gggagtgctc gaagtgctat gctattaatg ataacaaagt 1860 tggtgaggtg tgctcatttt atgctgatcc taaaagatat tttccagcaa tattttcagc 1920 tgaggtttta caaacaacaa taagcactat gatttcttgg atagaagatt gcaatgagct 1980 ggaagggcag ttgaacaata tcaggtctct gacaaagatg atcctggttt taattttagc 2040 tcaccccagt aaacgttctc aaaagctcct ccaaaatctt aggtactttg taatggctta 2100 tctatcagat tatcatcata aggacctcat tgacaaaata agggaagaat taatcactga 2160 tgttgagttc ctgctctata ggttaataag gacattaatg aatctggttt tatctgagga 2220 tgtgaagagc atgatgacta ataggttcaa gttcattttg aatgtttcct acatgtgcca 2280 cttcattacg aaagaaacac cagatagatt gacagatcag ataaaatgtt ttgagaagtt 2340 tctggaacca aaggtgagat ttggtcatgt gagcactaat cctgcagaca cagccactga 2400 ggaagaattg gatgacatgg tctacaatgc aaaaaagttt ttaagtaaag atggatgcac 2460 aactatcgag ggaccagatt ataaaaggcc tggtgtttca aagaagtatt tatctcttct 2520 tacatcctct tttaacaatg gttcactatt taaggagagg gaagtaaaaa gggaaatcaa 2580 agatcctctc atcaccagtg gcagtgcagc cttggattta gccagcaaga aaagtgttgt 2640 tgttaataaa tacacagatg gttctagaat attaaactat gacttcaata agctcacagc 2700 actggccgtg tcgcagctca ctgaagtctt ctcaaggaaa ggaaagtacc ttctcaacaa 2760 gcaggactat gagtacaaag ttcagcaggc aatgagcaat ttggttctag gatctgggca 2820 gctcaaaagt gatgctgatg gggctgacct agacgaaatt ttgctcgatg gaggtgcaag 2880 cgattatttt gatcagctaa aggagactgt tgaaaaaatt gttgatcagt atagggaacc 2940 tgtcaagcta ggctcaggcc ctaatggtga tggccaacca tcaataaatg atctagatga 3000 gattgtctca aataagtttt acattaggtt gatcaagggt gaattatcca atcacatggt 3060 tgaggagttt gatcatgata tcttaccagg taaattttat gaagaattct gtaatgctgt 3120 ctatgagaat agtagattga agcagaagta tttttactgt ggacatatgt cacagtgtcc 3180 tattggagag ttgacaaagg cagtgtcaac aaggacatac tttaaccatg aatactttca 3240 gtgttttaag tccatactct tgatcatgaa tgcgaataca cttatgggga ggtacactca 3300 ttataagtca aggaacctta atttcaagtt tgatatgggt aaactctctg atgatgtaag 3360 aattagtgaa agggagagca attcagaggc acttagtaag gctctgtcac tgacaaactg 3420 taccacagca atgttaaaga atttgtgttt ttatagccaa gagtcgccac aatcttatga 3480 ctcagtggga cctgatacag gaaggcttaa gttttctttg tcatataaag aacaagtggg 3540 tggtaacaga gaattatata ttggtgatct tagaacaaag atgtttacta gacttataga 3600 agattacttt gaagctataa gcctacagtt atcagggagt tgcctgaaca acgagaagga 3660 atttgaaaat gctatccttt ccatgaaatt gaatgtttca ttggcacatg tgtcttatag 3720 catggatcat agtaagtggg gcccaatgat gtgtccattt ttgttcttga ctgtcttaca 3780 gaatttaatt ttcctctcaa aggacttgca agctgacata aaagggaggg actatctctc 3840 aaccctactt atgtggcata tgcacaaaat ggtggaaata ccttttaatg tggtgacagc 3900 catgatgaag tctttcatta aagcccaact agggttaagg aagaaaacta aacagtcaat 3960 aacagaagat ttcttttact ctaatttcca agctggtgta gtgccttctc acatcagttc 4020 aatacttgac atgggtcaag gaatattaca caacacatca gatttttatg ccctcatttc 4080 agagaggttc attaattatg ctatcagttg tatatgcggt ggtacgatag atgcttatac 4140 ctctagtgat gatcagattt ctctctttga tcaatctctc acagagcttt tgcaaagaga 4200 cccagaagaa tttaggactc taatagagtt ccactattat atgagtgatc aactcaataa 4260 gtttgtgagc cctaaaagtg tcattggcag gtttgttgca gagtttaaat ctagattttt 4320 tgtttgggga gatgaagtgc cattattgac aaagttcgtt gcagcagctc ttcacaatat 4380 aaagtgtaaa gagccacacc aactggcaga aacaattgac acaatcattg atcagtcggt 4440 tgcgaatggt gtccctgttc acttatgtaa tctaatacag aaaagaacct taaatccttt 4500 gcaatatgca agatacccta ttgacccatt cttattgaat tgcgagacag atgttagaga 4560 ctgggtagat ggcaaccgta gttataggat tatgaggcaa atagagggat tgattcctaa 4620 tgcttgcagc aagattagat ctatgttaag aaaactgtac aataggttga agactgggca 4680 actccatgaa gagttcacaa caaactattt gtctagtgag cacctctcat cactaagaaa 4740 tctttgtgag ctgttggatg ttgagccccc atctgagtct gaccttgagt attcttggct 4800 aaacttggct gcgcatcatc ctttaagaat ggtgttgaga caaaagataa tatattcagg 4860 tgctgtgaac ctagatgatg agaagattcc taccattgtc aaaacaatcc aaaataagtt 4920 gtcttccact ttcactcgag gtgcgcaaaa attgctgtct gaagctatca acaaatctgc 4980 attccaaagt tccattgcat ctggctttgt aggattgtgc agaacattgg gtagcaaatg 5040 tgttcgggga ccaaataaag agaatctgta tattaagtcc attcagtctc tgatttctga 5100 tgtcaaggga atcaaattgt tgacaaattc taatggcatt caatattggc aagttccgct 5160 agaacttaga aatggaagtg gaggtgaaag tgtggtcagt tatttcagac ccttgttatg 5220 ggattatatg tgcatctcct tatcaactgc aatagaactg ggtgcatggg tcttagggga 5280 acctaagaca gttaaggtgt ttgatttttt caaacataac ccttgtgact attttccctt 5340 aaagccaact gcatcaaaac tattggagga tagggttggt ttgaatcaca tcattcattc 5400 tttaagaagg ctgtacccat cagtgtttga gaaacacata ttaccattca tgagcgatct 5460 agcgtcaacc aaaatgaagt ggtcacccag aataaaattt ctagatctct gtgtagcgtt 5520 ggatgttaac tgtgaagcct tgtctcttgt ctcacacata gtaaaatgga aaagagagga 5580 acattacatt gtgttatcat ctgaattgag gttgtctcac agtaggacac atgaacccat 5640 ggtggaagaa agagtagtga gcactagtga tgctgttgac aatttcatga ggcaaattta 5700 ttttgagtct tacgtgagac catttgttgc gactacaaga acattggggt ccttcacgtg 5760 gtttccacac aagacatcag ttccagaggg tgaagggttg catagaatgg gtccattttc 5820 ttcatttgta gagaaagtta ttcacaaagg tgttgaaagg ccaatgttta agcatgatct 5880 gatgatgggt tatgcttgga tagactttga tattgagcca gctagattca atcaaaatca 5940 attgatcgca tcaggtttag ttgatcctaa gtttgactca ttggaggatt tctttgatgc 6000 cgtagcttca ctacctccag ggtctgcaaa actgagtcag acagtgaggt tccgtgttaa 6060 aagtcaagat gctagtttta aggaaagctt tgccatccac cttgagtata ctggctcaat 6120 gaatcaacag gccaagtatc tagtacatga tgtaaccgtt atgtactcag gtgcagtgag 6180 tccgtgtgtc ttgtcagact gttggagact ggttttgtca ggacctactt tcaagggcaa 6240 atcagcatgg tatgttgaca ccgagatcat taatgagttt ttaattgaca caaatcaact 6300 agggcatgtg acccctgttg agattgttgt tgatatggaa aggttgcagt ttacggagta 6360 tgactttgta ttggtgggtc cttgcactga accaaccccc ctggttgtgc ataggggagg 6420 cttgtgggaa tgtggaaaga aattggcatc ctttacacct gttatacaag accaggatct 6480 tgagatattt gtgagagagg ttggggacac ttcgtctgac ctgctgattg gggcattgag 6540 tgatatgatg atagacaggc tggggttaag gatgcagtgg tcaggggtgg acattgtctc 6600 cacacttagg gctgcagcgc cgagttgtga ggggatcttg agtgcggttc ttgaggcagt 6660 ggacaactgg gtggagttca agggttatgc tctctgttat agtaagtcaa ggggaaaggt 6720 gatggtacaa tcaagtggtg gtaaattgag attgaagggc agaacatgtg aggagctgac 6780 taggaaggat gaatgcatcg aagacattga gtagtttttt ggtgatggtt ggctcccccg 6840 gg 6842 // |
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