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EBI DbfetchID U58632; SV 2; linear; genomic DNA; STD; PRO; 12298 BP. XX AC U58632; XX DT 21-JUN-1996 (Rel. 48, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 6) XX DE Thermotoga neapolitana xylan catabolic cluster and associated ABC transport DE system, complete sequence. XX KW . XX OS Thermotoga neapolitana OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. XX RN [1] RP 1-12298 RA Yernool D.A., Sullivan R.F., Rani S.Y., Eveliegh D.E.; RT "Molecular and functional characterization of a xylan catabolic cluster and RT associated ABC transporter system from the hypothermophile Thermotoga RT neapolitana"; RL Unpublished. XX RN [2] RP 1-12298 RA Yernool D.A., Sullivan R.F., Eveleigh D.E.; RT ; RL Submitted (17-MAY-1996) to the EMBL/GenBank/DDBJ databases. RL Biochemistry & Microbiology, Cook College, Rutgers University, 309 Lipman RL Hall, New Brunswick, NJ 08903, USA XX RN [3] RC Sequence update by submitter RP 1-12298 RA Yernool D.A.; RT ; RL Submitted (22-SEP-1997) to the EMBL/GenBank/DDBJ databases. RL Biochemistry & Microbiology, Cook College, Rutgers University, 309 Lipman RL Hall, New Brunswick, NJ 08903, USA XX RN [4] RC Sequence update by submitter RP 1-12298 RA Yernool D.A., Sullivan R.F., Eveliegh D.E.; RT ; RL Submitted (23-SEP-2002) to the EMBL/GenBank/DDBJ databases. RL Biochemistry & Microbiology, Cook College, Rutgers University, 309 Lipman RL Hall, New Brunswick, NJ 08903, USA XX CC On Sep 23, 2002 this sequence version replaced gi:2429091. XX FH Key Location/Qualifiers FH FT source 1..12298 FT /organism="Thermotoga neapolitana" FT /mol_type="genomic DNA" FT /db_xref="taxon:2337" FT CDS complement(33..1073) FT /codon_start=1 FT /transl_table=11 FT /gene="xylB" FT /product="endo-1,4-beta-xylanase" FT /note="glycosyl hydrolase family 10" FT /db_xref="GOA:Q79C18" FT /db_xref="InterPro:IPR001000" FT /db_xref="InterPro:IPR013781" FT /db_xref="InterPro:IPR017853" FT /db_xref="UniProtKB/TrEMBL:Q79C18" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="AAN16480.1" FT /translation="MKGLPALLLLLIGCVSSFGSQDVPLRVLAEKLNIHIGFAAGNNFW FT SLPDAEKYMEVAKREFNILTPGNQMKWDTIHPERNRYNFEPAEKHVEFALKNDMIVHGH FT TLVWHNQLPGWLTGQEWSKEELLNILEDHVKTVVSHFRGRVKIWDVVNEAVSDSGTYRE FT SIWYRTIGPEYIEKALIWAKEADPDAILIYNDYNIEEINAKSNFVYNMIKNLREKGVPI FT DGIGFQMHIDYRGINYESFKKNLERFAELGLQIYITEMDRGFPLGGSVGYYLKKQAEVY FT RRIFEICLDNPAVRAIQFWGFTDKYSWVPGFFKGYGKALIFDENYNPKPCYFAIRELME FT EKLKER" FT RBS complement(1083..1088) FT /gene="xylB" FT RBS 1275..1280 FT /gene="xtpA" FT CDS 1291..3168 FT /codon_start=1 FT /transl_table=11 FT /gene="xtpA" FT /product="periplasmic binding protein" FT /note="ABC transporter; solute-binding protein, family 5" FT /db_xref="GOA:Q8GIP4" FT /db_xref="InterPro:IPR000914" FT /db_xref="UniProtKB/TrEMBL:Q8GIP4" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN16481.1" FT /translation="MRKFLVILFVVSIFTLFFAQQLPPGIPRNETFIADNLTGRAANPG FT NFNIWATWVWNDRGIQNLLLEPLWCVEYANGEIINALAAEPPKYNSDFTELTIKLRKGV FT YWSDGVPFTADDLIYTIELVKNTPGMGYNSQMQQVKEIVKVDDYTVVIKLKEPNSRFHT FT YFLDRWGALRPLPKHIFEKVEDPLTFDFNPPVGTGPYVLKGYDPGGYWTLWERREDWDR FT TPTGMLYGMPQPKYVLFITYGGPEKQVLAMAQHQLDAADLTLEALKAVLSRVKTARAGR FT RNFPWTVNIDPCVTGLHFNTAREPFNNPDVRWALTLAIDIVEYAANAFDGAVTLSPIHI FT PLTTAYYNWYFTKLEDWLKNFELDLGNGEKFKPYDPTAGFRLAEYAKKRGYPVPDNPEL FT IKRIFGPGWWKYAPDAAAKLLEKNGFYRDKDGKWHLPNGELWKITITTGTNPAHPGYRN FT AFAAAQAWKKFGIDVTVQTTDAAATLDQRGEFEVSTDWPAAEPWGGHPDLFRTLEPFHS FT KYIRPIGENAPWGNYARWSNPEMDKIIDEIQKTAWGDTKRLIELGVEGLKLLVKEMPTI FT PTFNYPGVIAWDEYYWTNYPGAENMYAQPYHHWPNFKYMLPFLKPTGRK" FT CDS 3251..4249 FT /codon_start=1 FT /transl_table=11 FT /gene="xtpB" FT /product="binding-protein-dependent transport system inner FT membrane component" FT /db_xref="GOA:Q8GIP3" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q8GIP3" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN16482.1" FT /translation="MRRYLLPRLVTYFLVIWVGITMIFFIPRFLPTDPVQQFINRLVAQ FT GTYMDPKAIEEMTETLKELYGLKGSLWEQYINFWKRFLKGDFGPSYYQFPTPVIKLIKQ FT SLPWTAWLLLVTTVLSWIIGNILGGLAGYFSNRRWVKILDAIAMVIRPMPYYILALGLL FT ILLAYIIPIFPIGGGFAIGMQFTFSWENLLILLKHAFLPALSLILIGVFIWFQAMKLVV FT QSVKSEDYVKYAKMGGIEEKRIVRRYVIRNAMLPQITGLALSLGQIFGGALITEIVFSY FT PGIGTLLYNAIFTGDYNLLMGVSTLSILLITTSILLIDLLYPLFDPRVRYR" FT CDS 4257..5120 FT /codon_start=1 FT /transl_table=11 FT /gene="xtpC" FT /product="binding-protein-dependent transport system inner FT membrane component" FT /db_xref="GOA:Q8GIP2" FT /db_xref="InterPro:IPR000515" FT /db_xref="UniProtKB/TrEMBL:Q8GIP2" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN16483.1" FT /translation="MERMQVLKDLLRDTRFRFGFIVFLVLAGLSVLSFFSPYNPYLWNQ FT VPRDLPPQWPHILGTNSMGQDIFWKLTFAVRNSLIMSLIAGLVSRVIAMIVGMIAGYKG FT GAADRVLMFLSDSFLVIPLFIIIVLIATMVKARLSLPMLGLLLGVFGWAWDARVIRSQV FT LSLRERDFTYTALLSGSKALAIVFKEYLPFLIPLIFATLIGNMSWAIGMEITLAILGVS FT NLDIPTLGTMLQWSINYQALLLGYWWWVLTPVITSIFLFIALYLISVSISEYLDPRMRI FT QRIGQA" FT CDS 5122..6129 FT /codon_start=1 FT /transl_table=11 FT /gene="xtpD" FT /product="ATP-binding protein" FT /note="ABC transporter" FT /db_xref="GOA:Q8GIP1" FT /db_xref="InterPro:IPR003439" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR010066" FT /db_xref="InterPro:IPR013563" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:Q8GIP1" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN16484.1" FT /translation="MIAVEVLRTENLKSYYILDIFGKKRVVKAVDDVNISIRENEIYGI FT AGESGCGKSTLLKALFAAIEPPQRIVGGKVLYRENGREIDVYSLSEEERRKLRWSFISY FT VPQGSMSVLNPVVKIKETFKDFIESHTTGKTKEEAYEMAKEHIKELGLPIEILNAYPHQ FT LSGGMRQRVTIALATVLSPKVIIADEPTTALDVVTQRGVIQLLKEVQSSRQNTIILVTH FT DMGVHANVADRIAIMYAGKIIEEAKTEEIFENPMHPYTKYLIFSLPKFGDKGRRESAPG FT SPPSLADLPPGCSFHPRCPHAFDRCKKEIPPLKEYLPGHKVACWLVEEGKNATS" FT RBS 6103..6108 FT /gene="xtpF" FT CDS 6116..7072 FT /codon_start=1 FT /transl_table=11 FT /gene="xtpF" FT /product="ATP-binding protein" FT /note="ABC transporter" FT /db_xref="GOA:Q8GIP0" FT /db_xref="InterPro:IPR003439" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR010066" FT /db_xref="InterPro:IPR013563" FT /db_xref="InterPro:IPR017871" FT /db_xref="UniProtKB/TrEMBL:Q8GIP0" FT /inference="non-experimental evidence, no additional FT details recorded" FT /protein_id="AAN16485.1" FT /translation="MPLLEIKNLTKIFTIGSIFSRTKIVAVDRVNFDIKEAEIFTLAGE FT SGCGKTTTAKIILGFEEPTSGEIVYKGKRIERVHEKERKELLREIQAVFQNPFSTFNPL FT RKVDRYFYETLFNLGIADTKEKAEEIIREKLSAVGISFEEFSEKYPSEFSGGQLQRISI FT ARALLTNPSLLVADEPVSMVDASLRMSIVNLFKDLKEQYGVSVLYITHDLTTAYYVSDR FT IAVMFRGNIVELGPAEKVLMEPKHPYTQLLRESVPEPDPKKKWNIRIKLSETEQTEYLR FT QGCKFAGRCPKVMDICKKEPPPYFEVDGVQVKCFLYR" FT CDS 7082..8122 FT /codon_start=1 FT /transl_table=11 FT /gene="xylC" FT /product="endo-1,3-beta-xylanase" FT /note="glycosyl hydrolase family 26" FT /db_xref="GOA:O33841" FT /db_xref="InterPro:IPR013781" FT /db_xref="InterPro:IPR017853" FT /db_xref="UniProtKB/TrEMBL:O33841" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="AAB70868.1" FT /translation="MKRFIFLAIAMIFTVLEGKILLVIGQDLNSVREYAKSGYFPEPGG FT VTTYTDIATLNGLCNDADWGAGLINAKKCLEEFPNSALVIGLYMVNMVDGVISGEYDRQ FT IEILAEFIKEANRPVYLRIGYEFDGIWNSYDPEKYRVAFRYITEKLRNLLGERKKLLFT FT VWQSCSSPLNVILRNYQKPDISLWYPGDDYVDFVGLSWFLPANMKYHGKTPTQKELAEE FT VLAFARLHNKPVMISEASPQGYDLSELTKANISPVLDGPSGKNRVKKTPEEIWNEWFKP FT FFEFVYENSDVIRVVAYINADWDSQPMWGPPYANGYWGDSRVQVNPIIRNLWLKEIKKS FT IWEHGE" FT CDS 8135..10471 FT /codon_start=1 FT /transl_table=11 FT /gene="xloA" FT /product="beta-xylosidase" FT /note="glycosyl hydrolase family 3" FT /db_xref="GOA:Q56322" FT /db_xref="HSSP:1EX1" FT /db_xref="InterPro:IPR001764" FT /db_xref="InterPro:IPR002772" FT /db_xref="InterPro:IPR017853" FT /db_xref="InterPro:IPR019800" FT /db_xref="UniProtKB/TrEMBL:Q56322" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="AAB70867.1" FT /translation="MELYRDPSQPVEVRVKDLLSRMTLEEKIAQLGSVWGYELIDERGK FT FKREKAKDLLKNGIGQITRPGGSTNLEPQEAAELVNEIQRFLVEETRLGIPAMIHEECL FT TGYMGLGGTNFPQAIAMASTWDPDLIEKMTAAIREDMRKLGAHQGLAPVLDVARDPRWG FT RTEETFGESPYLVARMGVSYVKGLQGENIKEGVVATVKHFAGYSASEGGKNWAPTNIPE FT REFREVFLFPFEAAVKEARVLSVMNSYSEIDGVPCAANRRLLTDILRKDWGFEGIVVSD FT YFAVNMLGEYHRIAKDKSESARLALEAGIDVELPKTDCYQHLKDLVEKGIVPESLIDEA FT VSRVLKLKFMLGLFENPYVDVEKAKIESHRDLALEIARKSIILLKNDGTLPLQKNKKVA FT LIGPNAGEVRNLLGDYMYLAHIRALLDNIDDVFGNPQIPRENYERLKKSIEEHMKSIPS FT VLDAFKEEGIDFEYAKGCEVTGEDRSGFKEAIEVAKRSDVAIVVVGDRSGLTLDCTTGE FT SRDMANLKLPGVQEELVLEIAKTGKPVVLVLITGRPYSLKNLVDRVNAILQVWLPGEAG FT GRAIVDVIYGKVNPSGKLPISFPRSAGQIPVFHYVKPSGGRSHWHGDYVDESTKPLFPF FT GHGLSYTRFEYSNLRIEPKEVPSAGEVVIKVDVENVGDMDGDEVVQLYIGREFASVTRP FT VKELKGFKRVSLKAKEKKTVVFRLHTDVLAYYDRDMKLVVEPGEFRVMVGSSSEDIRLT FT GSFSVTGSKREVVGKRKFFTEVYEE" FT CDS 10478..11455 FT /codon_start=1 FT /transl_table=11 FT /gene="axeA" FT /product="acetyl xylan esterase" FT /db_xref="HSSP:1L7A" FT /db_xref="InterPro:IPR008391" FT /db_xref="UniProtKB/TrEMBL:O33842" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="AAB70869.1" FT /translation="MAFFDMPLEELKKYRPERYEEKDFDEFWRETLKESEGFPLDPVFE FT KVDFHLKTVETYDVTFSGYRGQRIKGWLLVPKLAEEKLPCVVQYIGYNGGRGFPHDWLF FT WPSMGYICFVMDTRGQGSGWMKGDTPDYPEGPVDPQYPGFMTRGILDPGTYYYRRVFVD FT AVRAVEAAISFPRVDSRKVVVAGGSQGGGIALAVSALSNRVKALLCDVPFLCHFRRAVQ FT LVDTHPYVEITNFLKTHRDKEEIVFRTLSYFDGVNFAARAKVPALFSVGLMDTICPPST FT VFAAYNHYAGPKEIRIYPYNNHEGGGSFQAIEQVKFLKRLFEEG" XX SQ Sequence 12298 BP; 3451 A; 2876 C; 3098 G; 2873 T; 0 other; actgctgaga agaaaggggg catcgccccc ttttatcttt ccttcagttt ttcctccatg 60 agttccctta ttgcaaaata gcacggtttt gggttgtagt tttcatcgaa gatcaacgcc 120 ttgccgtaac ctttgaagaa acccggcacc caggagtatt tgtctgtgaa tccccagaac 180 tggatcgccc tgacagcggg gttgtccaga cagatctcga agatcctcct gtagacttcc 240 gcctgttttt tcagatagta ccctaccgat ccaccaaggg gaaacccacg gtccatttcc 300 gtgatgtaga tctgaagccc aagctctgcg aatctttcca ggtttttctt gaaactctcg 360 tagttgattc ccctgtaatc tatatgcatc tgaaacccta ttccatctat gggaactcct 420 ttttccctca ggttctttat catgttgtag acgaagttgg acttggcgtt gatctcttcg 480 atgttgtaat cgttgtagat gagaatcgca tccggatctg cttcctttgc ccagatgagg 540 gccttttcaa tgtactcagg accgatcgtt ctgtaccata tgctttctct gtaggttcca 600 gagtcactca ccgcttcgtt cacaacatcc cagatcttca ctctgcccct gaagtgagat 660 accaccgtct ttacgtgatc ttcaagaatg ttcaggagtt cttctttcga ccactcctgg 720 cctgtgagcc atccaggaag ctggttgtgc cagacgaggg tgtgaccgtg cacaatcata 780 tcgtttttca gggcaaattc aacatgtttt tcggcaggtt caaagttgta tctgtttctt 840 tccggatgga tggtgtccca cttcatctgg tttccgggcg tgaggatgtt gaactctctt 900 tttgcaactt ccatgtactt ttctgcgtcg ggaagagacc agaagttgtt ccctgctgca 960 aatccgatgt gaatgttcaa cttctctgcg agcactctca agggaacatc ctgtgaaccg 1020 aaggacgaaa cacacccgat cagaagtaac agcagagcag gcaacccttt cataacatga 1080 aacctccttt ttcatttgtg tacggaaata tgataccata aagaaaaaag ggaaaaagaa 1140 gaaaaacgac aatattctga aataatctcc tgtagtccgg aataatcttc aatatttatg 1200 aaaaatggat cttgattttt cagggagatt tacattaaaa tatttcccga aaggaaaaaa 1260 tatacataca atcaagggag gtgagttttc atgaggaagt ttcttgtgat cctgttcgtt 1320 gtttccatct tcaccctgtt ctttgcacag caacttccac cagggattcc cagaaatgag 1380 acgttcatag ccgacaacct aacgggtaga gctgccaacc ccggtaactt caacatctgg 1440 gctacttggg tctggaacga caggggtatc cagaatctcc ttctggaacc actctggtgc 1500 gttgagtacg ccaacggaga gatcatcaac gctcttgccg ctgaacctcc aaagtacaac 1560 tccgacttca cagaactcac cataaaactc agaaaaggtg tctactggag tgatggtgta 1620 ccgtttacag cagatgacct aatttatacc atcgagctcg tcaaaaacac accgggaatg 1680 gggtacaact cccagatgca gcaggtaaaa gagatcgtga aggtggacga ttacacggtc 1740 gtgatcaagc ttaaagagcc taattccaga ttccacacct acttcctcga cagatggggc 1800 gctctgagac ctcttccaaa gcacatattt gagaaagtgg aagatcctct cacgttcgat 1860 ttcaatccgc ccgttggaac aggaccttac gttctcaaag gatacgatcc cggaggatac 1920 tggacgctct gggaaagaag agaagactgg gacagaacac caacaggaat gctatatggc 1980 atgccacaac caaaatacgt gctcttcatc acgtatggtg gtcccgaaaa gcaggttctc 2040 gccatggcac agcaccagct cgatgcagct gacctcacac ttgaagccct caaagccgtt 2100 ctcagcagag tcaaaactgc aagggccggg agaagaaact tcccgtggac cgtcaacatc 2160 gacccatgtg tgacagggct tcacttcaac acagccagag aacccttcaa caatcctgat 2220 gtgagatggg cactcacact tgcgatcgac atcgttgaat atgccgccaa cgcgttcgat 2280 ggagcggtca ccctgagtcc cattcacatt cctctcacaa ccgcatacta caactggtac 2340 ttcacaaaac tcgaagactg gctgaagaac ttcgaactcg accttggaaa cggagaaaag 2400 ttcaaacctt atgatccaac agcaggattc agactggccg aatacgcaaa gaagagagga 2460 tatcctgtgc ctgacaatcc agaactgatc aagaggatct ttggacccgg atggtggaag 2520 tacgcacccg atgctgcagc aaaacttctt gaaaagaacg gattctacag agacaaagat 2580 ggaaaatggc acctgcccaa cggtgaactc tggaaaatta ccatcaccac gggaaccaat 2640 ccggctcacc cgggttacag aaacgccttt gcagccgctc aggcgtggaa gaaattcggt 2700 atcgatgtaa cggtccagac aacggatgca gcggcaactc ttgatcagag aggagaattc 2760 gaagtctcaa cagactggcc agcggcggag ccatggggag gacatccaga tctgttcaga 2820 acactcgagc cgttccactc caaatacatc agacccattg gagaaaacgc cccatggggc 2880 aactacgcaa gatggagcaa tcctgagatg gacaagatca tagacgagat acagaagaca 2940 gcctggggag acacaaagag gctcatcgaa cttggagttg aaggtttgaa gcttcttgtc 3000 aaagagatgc cgacgatacc aacgttcaac tacccgggtg tcatcgcatg ggatgaatac 3060 tactggacga actatcctgg tgcggagaac atgtatgcac agccgtacca tcactggccc 3120 aacttcaagt acatgctccc gttcttgaaa ccaaccggta gaaaatgatg taaaatatct 3180 ttcaaacggg ggccgggggg ataacccccg gtcctttaaa gaggaaagga ggtcagagat 3240 cttgaacttc gtgagaaggt atctcctccc aagactggta acgtactttc ttgttatctg 3300 ggtaggaatc acgatgatct ttttcatacc aaggtttctg ccaacagatc cggtacagca 3360 gttcataaat cgtcttgtgg cacaaggaac gtacatggac ccgaaggcga tagaagagat 3420 gacagaaacc ctaaaagaac tttacggact gaagggaagt ttgtgggaac agtacataaa 3480 cttctggaaa cgctttttaa agggagactt cggtccctcc tactatcagt ttccaacacc 3540 cgtgataaaa ctgataaaac agtctttgcc ctggaccgca tggcttcttc tggtgacaac 3600 tgttctttcc tggatcatag gaaacatcct tggaggtctt gcggggtact tttcgaacag 3660 aagatgggtg aagatacttg acgccatcgc gatggtgata agaccgatgc cgtactacat 3720 ccttgccctt gggcttctga ttcttctcgc atacatcatt cccatcttcc caattggggg 3780 cggctttgca ataggaatgc agttcacctt cagctgggaa aaccttctga tcctattgaa 3840 acacgcgttc ctgccggctc tgtctctgat attgatcggt gtattcatct ggttccaggc 3900 gatgaagctc gtcgttcaga gtgtgaagtc agaggactac gtgaagtacg ccaagatggg 3960 tggaatagaa gagaaaagaa tcgttcgaag atacgttata aggaacgcca tgttgccaca 4020 gataacagga cttgctctat ctttaggtca gatctttgga ggtgccctga tcacggagat 4080 cgtgttctcc tacccaggca ttggaacact cctttacaac gccatattca caggtgacta 4140 caacctcttg atgggtgtca gcacactttc catccttctg attacaacga gtattctttt 4200 gatagatctg ctttatcctc tgttcgatcc gagggtgaga tacagatgaa aagggagtgg 4260 aaagaatgca ggtgctgaag gatctgttga gagatacacg cttcagattt ggctttatag 4320 tatttctggt tcttgcggga ctttctgttc tatctttctt ttcgccctac aacccttacc 4380 tgtggaacca ggttccaagg gaccttcctc cccagtggcc tcacatactg ggtacaaact 4440 ccatgggaca ggatatcttc tggaaactca cctttgccgt gaggaactca ctcatcatgt 4500 cgctcatagc aggccttgtc tcaagggtca tagcgatgat cgtgggaatg atcgccggat 4560 acaagggagg agctgctgac agggttctca tgtttctgag tgactctttc cttgtgatac 4620 cccttttcat cataatcgtt ctcatcgcca cgatggtgaa ggctcgactc agtctaccta 4680 tgctgggact tcttcttggc gtcttcggct gggcatggga cgcgagggtc ataagatccc 4740 aggttttgag tctgagagag agggatttca cctacaccgc cctcctttca ggttcgaagg 4800 cgctggccat cgtcttcaaa gagtatctgc cgtttttgat ccctctcatc ttcgcaacgc 4860 tcatcggtaa catgtcctgg gcgatcggaa tggagatcac actcgcaatc ctgggtgttt 4920 ccaacctcga tattccaacc cttggcacca tgctccagtg gtcgataaac taccaggcac 4980 ttcttctggg atactggtgg tgggtattga caccggtcat aacatcaatc tttctgttca 5040 tagcgctgta tctcatctcg gtcagcatca gtgagtatct tgatccgagg atgaggatac 5100 agagaatagg acaggcatga ggtgatagcg gtggaagtgt tgaggacaga gaatctcaaa 5160 tcttactaca ttctggacat attcggcaaa aagagagtgg taaaagcggt ggacgatgtg 5220 aacatctcga taagagagaa cgagatatac ggcatagcag gagagagcgg ctgtggaaag 5280 agcacgcttc ttaaagcact ctttgctgcg atagagccac ctcagaggat cgtgggagga 5340 aaggtactgt acagagagaa cggaagagaa atagatgttt actctctcag tgaagaagaa 5400 cgaaggaaac ttaggtggag tttcatctct tacgttccac agggatcgat gagcgtgttg 5460 aatcctgtgg tgaagataaa agagaccttc aaggacttca tagagagtca cacaactgga 5520 aagacaaagg aagaggccta cgagatggca aaagaacaca taaaagaact tggccttccg 5580 atagagattc tcaacgccta tccacaccag ctgtccggtg gaatgagaca gagggtgacg 5640 atcgcccttg cgaccgttct atcaccgaag gtgatcatcg cagacgagcc cacaacggcc 5700 ctcgacgttg tgacacagag aggtgtaata cagcttctca aagaggtaca gtcctcaaga 5760 cagaacacca tcattctggt cacacacgac atgggagttc atgcaaacgt ggcagacagg 5820 atagcgatca tgtacgctgg aaagatcata gaggaagcaa agaccgaaga gatctttgaa 5880 aaccccatgc atccctacac gaaatacctg atattctcac ttccgaagtt cggagacaag 5940 ggaagaagag agagtgcccc tggaagtcct ccttcccttg cagaccttcc accaggatgc 6000 agtttccatc caagatgtcc tcatgcgttc gacaggtgca aaaaggagat accacctctc 6060 aaagagtacc tgccaggaca caaagtcgca tgctggctgg tagaggaggg aaagaatgcc 6120 acttcttgag ataaaaaacc tgacgaagat cttcaccata gggagcatct tttccagaac 6180 gaagatagtg gccgtggaca gggtgaactt cgacataaaa gaggcggaga tcttcacact 6240 ggctggagag agtggctgtg gaaagaccac cacggcaaag atcatccttg gattcgaaga 6300 gcccacctcc ggagagatcg tctacaaagg aaagaggata gaaagggtgc atgaaaaaga 6360 gaggaaagaa ctcttgaggg agatacaggc ggtcttccag aatccgtttt ccacgttcaa 6420 ccccctcagg aaggtggaca ggtacttcta cgagacactt ttcaatctgg gaatagcaga 6480 tacaaaagag aaggcagaag agatcatcag ggaaaaactc tccgccgttg gaatctcctt 6540 tgaggagttc tcagaaaagt atccgagtga gttctcgggt gggcagcttc agaggatctc 6600 catagcaagg gcgcttctta caaatccatc gcttcttgtg gcagacgaac ccgtttccat 6660 ggtggacgca tccctgagga tgtccatcgt gaacctattc aaggacctca aagaacagta 6720 cggtgtgagt gttctgtaca tcacacacga cctcacaaca gcgtattatg tctcagacag 6780 aatcgctgtc atgttcagag ggaacatagt ggaactggga ccggcagaga aggttctcat 6840 ggagccaaaa cacccttaca cccagcttct gagagagtcc gttcctgagc ctgatccgaa 6900 gaagaaatgg aacatcagaa taaagttgtc tgagacagaa caaacagaat acctcaggca 6960 gggctgcaag ttcgccggaa gatgtccgaa ggtgatggac atctgcaaaa aagaaccacc 7020 tccatacttc gaagtcgatg gtgtccaggt gaagtgtttc ctttacagat agggtgaaaa 7080 catgaaaaga ttcatttttc tggcaattgc aatgatcttt acagttctgg aagggaaaat 7140 acttcttgtc atcggacagg atctgaactc ggtcagagag tacgcaaaat cagggtactt 7200 cccagaacct gggggagtga caacgtacac cgatatagca actctcaacg gtctctgcaa 7260 cgacgctgac tggggagcgg gcttgataaa cgcgaagaaa tgcctggaag agttcccaaa 7320 ctctgcgctt gtgataggac tgtacatggt aaatatggtg gatggtgtga tttctgggga 7380 gtatgatcgt cagatagaga ttcttgctga attcatcaaa gaagcaaaca gaccggtgta 7440 tctcagaatc ggatacgaat tcgatggaat atggaacagc tacgatccag aaaagtacag 7500 agtcgccttc aggtacataa ccgaaaaact cagaaatctg ctgggagaga gaaaaaaact 7560 tctcttcaca gtgtggcagt cgtgttcttc tcccctgaac gtcatacttc ggaactatca 7620 aaaaccggac atttcactct ggtatccagg tgatgattat gtggatttcg tagggctgtc 7680 gtggttctta cctgcgaaca tgaaatacca tggaaagaca cccactcaga aagagctggc 7740 agaagaggtg ttggcttttg caaggcttca caacaaaccc gtgatgatat cagaagccag 7800 tccacagggg tatgatcttt cagaactcac aaaggcaaac atcagtcccg ttcttgacgg 7860 tccttctgga aagaatagag taaaaaagac accagaagag atctggaacg agtggttcaa 7920 gccttttttt gagttcgtgt atgaaaattc agacgtaata agggtggtgg catacataaa 7980 cgccgactgg gattcacagc ccatgtgggg gccgccttat gcgaacggat actggggaga 8040 cagcagggtt caggtcaatc ccatcatcag aaacctgtgg ctgaaggaaa tcaaaaaatc 8100 catatgggaa cacggcgaat gaggagggaa agttatggaa ctgtacaggg acccatcaca 8160 accagtcgag gtgagggtga aagatcttct ttcgaggatg actctggaag agaaaattgc 8220 tcaactcggt tctgtctggg gatacgagtt gatagatgag agaggaaagt tcaaaagaga 8280 aaaggcaaaa gatcttctaa aaaacggcat cggccagatc acgcgtcctg gaggctccac 8340 gaaccttgag ccacaagaag ctgcagaact tgtgaacgaa atacagcgct ttcttgtgga 8400 ggaaacacgt cttggaatac ctgcgatgat acacgaagag tgtctcaccg gatacatggg 8460 tcttggtgga accaacttcc cacaggcaat agcgatggcg agcacctggg atccagatct 8520 catagagaaa atgacagcgg ccatcagaga ggacatgagg aagttaggag cgcaccaggg 8580 actcgctcct gttctggacg tggcaagaga tccaaggtgg ggaagaacgg aggaaacgtt 8640 cggggagtct ccttaccttg tcgcaaggat gggtgtttcc tacgtgaaag gactccaggg 8700 tgaaaacata aaagaaggcg ttgtcgctac ggtgaaacac tttgcaggat acagcgcttc 8760 tgaaggcgga aagaactggg caccgacgaa cattcctgaa agagagttca gagaagtctt 8820 tcttttccca tttgaagctg cggtcaaaga agcaagagtg ctttctgtga tgaactccta 8880 cagtgaaata gacggtgtgc cctgtgcagc aaacagaagg cttctcaccg atattctgag 8940 aaaagactgg ggattcgagg gtatcgttgt ttccgactac tttgcggtga acatgctcgg 9000 agaataccac aggatagcga aagacaaatc tgaatctgca agactcgccc tcgaagcggg 9060 aatagacgtt gaacttccaa agacagactg ttatcagcac cttaaggatc tcgtcgaaaa 9120 gggaattgtg cccgaatcgc tgatcgacga ggccgtttcc agggtactga aactcaagtt 9180 catgctcggt ctcttcgaga atccgtacgt cgatgtggaa aaggcaaaga tagaaagcca 9240 cagagacctt gccctcgaaa tcgcaagaaa atccatcatc ctcctcaaaa acgacggaac 9300 gctgcccctc cagaaaaaca aaaaagtcgc tctgatagga ccgaacgcgg gtgaggtgag 9360 gaaccttctt ggcgactaca tgtaccttgc ccacataagg gcactcctcg acaacataga 9420 cgatgtcttt ggaaatccgc agattccaag ggaaaactac gaaagattga aaaagagtat 9480 agaagagcac atgaagagca ttccaagcgt tctcgatgcc ttcaaagaag agggtattga 9540 tttcgagtat gcgaagggat gcgaagtgac aggagaagac agaagcgggt tcaaagaagc 9600 gatcgaagtt gcaaaaagat cagacgttgc catcgttgtg gtcggagaca gatccggcct 9660 caccctcgac tgcacaacgg gtgaatccag agacatggca aacctgaaac tccccggcgt 9720 acaggaagaa ctcgtcctcg aaattgcaaa aacaggaaaa cctgtcgttc ttgtcctcat 9780 cacaggaaga ccctactcac tcaaaaacct ggtcgacagg gtgaacgcta ttcttcaggt 9840 gtggctccct ggagaggcag gtggaagagc gatcgtcgat gtcatctacg gaaaggtgaa 9900 tccctctgga aagctcccga tcagtttccc aaggagtgca ggccagatcc ccgtctttca 9960 ctacgtcaaa ccctctggag gaaggtctca ctggcatgga gactatgtgg acgagagcac 10020 aaagcccctc tttcccttcg gacacggcct gtcctacacg aggtttgagt acagcaacct 10080 gaggatagag ccgaaggagg taccatctgc aggagaggtt gtgataaagg tcgatgtaga 10140 aaacgtggga gatatggatg gtgacgaggt ggttcagctt tacatcggtc gtgagtttgc 10200 aagtgtcaca aggcctgtga aggagttgaa ggggttcaag agggtttctt tgaaggcaaa 10260 agagaagaag acggttgtgt tcagacttca cacggatgtt ctcgcatatt acgacaggga 10320 catgaagctt gttgtggaac ccggtgagtt cagggtgatg gtgggtagtt cctctgagga 10380 catcagactc accggttctt tctccgtcac cggaagcaaa agagaagtcg taggaaagag 10440 aaagtttttc acagaggtct acgaggagtg atgaaaaatg gccttcttcg atatgcccct 10500 tgaggaactg aaaaagtacc ggcctgaaag gtacgaggag aaagatttcg atgagttctg 10560 gagggaaaca cttaaagaaa gcgaaggatt ccctctggat cccgtctttg aaaaggtgga 10620 ctttcatctc aaaacggttg aaacgtacga tgttactttc tctggataca gggggcagag 10680 aataaagggc tggcttcttg ttccgaagtt ggcggaagaa aagcttccat gcgtcgtgca 10740 gtacataggt tacaatggtg gaaggggttt tccacacgac tggctgttct ggccgtcaat 10800 gggttacatc tgttttgtca tggacaccag ggggcaggga agcggctgga tgaagggaga 10860 cacaccggat taccctgagg gtccagtcga tccacagtac cccggattca tgacgagggg 10920 cattctggat ccgggaacct attactacag gcgagtcttc gtggatgcgg tcagggcggt 10980 ggaagcagcc atttccttcc cgagagtgga ttccaggaag gtggtggtgg ccggaggcag 11040 tcagggtggg ggaatcgccc ttgcggtgag tgccctgtcg aacagggtga aggctctgct 11100 ctgcgatgtg ccgtttctgt gccacttcag aagggccgtg caacttgtcg acacacaccc 11160 atacgtggag atcaccaact tcctcaaaac ccacagggac aaagaggaga ttgttttcag 11220 aacactttcc tacttcgatg gtgtgaactt tgcagcaagg gcaaaggtgc ccgccctgtt 11280 ttccgttggg ctcatggaca ccatctgtcc tccctcgacg gtcttcgccg cttacaacca 11340 ctacgccggt ccaaaggaga tcagaatcta tccgtacaac aaccacgaag gtggaggttc 11400 tttccaggca attgagcagg tgaaattctt gaagagacta tttgaggaag gctagaggct 11460 tttttgtcac aggatgtgtt agtacgacaa attccgtttc aaaaacactt cggagcaccc 11520 ccttcgtcga ggacctcggt gggtgctccg atttttatga tcctgccgtt tttcatcaca 11580 gccagtctgt cacacagaag cgatgccacg tttatatcgt gaaaaaccgc cacgatggtc 11640 tttccggact ctttcaactt tctcatcacg ttgcccacaa gactcacgtt actgtaatca 11700 agatgagcgg tcagttcgtc cacaaggagg atcttcgtat cctgggcgat tgcctttgaa 11760 agcacaacct ttcttcgttc accggcactc agcgtccaga aagttctgga ggaaaatttc 11820 aaggtgtcgg tcagttccag actcttaaga acgatctcct cgtctctttt gctcgctcca 11880 ttcagaagac gctgatgtgg aagtctcccc atttcaacga tctctttcag gtgaaatcgt 11940 cgagggaaag aaatcctgag aaacgagggt tactggtctt tgccatctct tttctggaaa 12000 cttcccaggg aaccttccca aagagaagca ctgttccttt ctgaggcttc agaagtcctg 12060 atagtatctt caaaagggtg gtcttaccgg atccgttggg acctattatc ccaaaaaact 12120 ctccttcttc tacagagaat tccaatattc tccagagaaa aacccgtcct gtatcgaaaa 12180 tacagattct ctaccttcac cgccttcaac tcacacaccc cttttcatga gaaaggcgag 12240 aaaaggagcg cccaacagcg cggtcacaat cccaacggga agttccgttg gggaaaat 12298 // |
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