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EBI DbfetchID U49938; SV 2; linear; genomic DNA; STD; PRO; 7147 BP. XX AC U49938; L34547; XX DT 27-DEC-1996 (Rel. 50, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 6) XX DE Borrelia burgdorferi potential virulence gene cluster, partial sequence; DE putative protein 4, magnesium ion transporter MgtE (mgtE), and protein DE kinase C1 inhibitor Pkci (pkci) genes, complete cds. XX KW . XX OS Borrelia burgdorferi (Lyme disease spirochete) OC Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia; OC Borrelia burgdorferi group. XX RN [1] RP 218-1510 RX DOI; 10.1016/0378-1097(94)90277-1 RX PUBMED; 7988902. RA Aron L., Alekshun M., Perlee L., Schwartz I., Godfrey H.P., Cabello F.C.; RT "Cloning and DNA sequence analysis of bmpC, a gene encoding a potential RT membrane lipoprotein of Borrelia burgdorferi"; RL FEMS Microbiol. Lett. 123(1-2):75-82(1994). XX RN [2] RP 218-7147 RX DOI; 10.1016/S0378-1097(96)00355-2 RX PUBMED; 8978084. RA Aron L., Toth C., Godfrey H.P., Cabello F.C.; RT "Identification and mapping of a chromosomal gene cluster of Borrelia RT burgdorferi containing genes expressed in vivo"; RL FEMS Microbiol. Lett. 145(3):309-314(1996). XX RN [3] RP 1-7147 RX DOI; 10.1128/JB.182.7.2037-2042.2000 RX PUBMED; 10715014. RA Gorbacheva V.Y., Godfrey H.P., Cabello F.C.; RT "Analysis of the bmp gene family in Borrelia burgdorferi sensu lato"; RL J. Bacteriol. 182(7):2037-2042(2000). XX RN [4] RP 1-7147 RX DOI; 10.1046/j.1365-2958.2001.02220.x RX PUBMED; 11136458. RA Dobrikova E.Y., Bugrysheva J., Cabello F.C.; RT "Two independent transcriptional units control the complex and simultaneous RT expression of the bmp paralogous chromosomal gene family in Borrelia RT burgdorferi"; RL Mol. Microbiol. 39(2):370-378(2001). XX RN [5] RP 218-7147 RA Aron L., Toth C., Godfrey H.P., Cabello F.C.; RT ; RL Submitted (23-FEB-1996) to the EMBL/GenBank/DDBJ databases. RL Pathology, New York Medical College, Basic Science Building, Valhalla, NY RL 10595, USA XX RN [6] RC Sequence update by submitter RP 1-7147 RA Gorbacheva V.Y., Godfrey H.P., Cabello F.C.; RT ; RL Submitted (27-DEC-1999) to the EMBL/GenBank/DDBJ databases. RL Microbiology and Immunology, New York Medical College, Basic Science RL Building, Valhalla, NY 10595, USA XX CC On Dec 27, 1999 this sequence version replaced gi:1753223. XX FH Key Location/Qualifiers FH FT source 1..7147 FT /organism="Borrelia burgdorferi" FT /strain="297" FT /mol_type="genomic DNA" FT /db_xref="taxon:139" FT CDS <1..77 FT /codon_start=3 FT /transl_table=11 FT /gene="bmpD" FT /product="membrane lipoprotein BmpD" FT /db_xref="UniProtKB/TrEMBL:Q9REH8" FT /protein_id="AAF20163.1" FT /translation="IMNGIIKVPYDKVSYDNFVLQMEN" FT -35_signal 295..300 FT /gene="bmpC" FT -10_signal 318..323 FT /gene="bmpC" FT mRNA 329..1456 FT /gene="bmpC" FT /product="membrane lipoprotein BmpC" FT RBS 379..384 FT /gene="bmpC" FT CDS 395..1456 FT /codon_start=1 FT /transl_table=11 FT /gene="bmpC" FT /product="membrane lipoprotein BmpC" FT /db_xref="GOA:O50169" FT /db_xref="InterPro:IPR003760" FT /db_xref="UniProtKB/Swiss-Prot:O50169" FT /protein_id="AAC44711.1" FT /translation="MFKRFIFITLSLLVFACFKSNKKSIKSDKVVVGVLAHGSFYDKGY FT NQSVHDGVVKLRDNFGIKLITKSLRPYPIEGKRLLTVDEAMTEDAYEVQKNPLNLFWLI FT GYRFSDLSVKLSYERPDIYYGIIDAFDYGDIQVPKNSLAIKFRNEEAAFLAGYIAAKMS FT RKEKIGFLTGPMSEHLKDFKFGFKAGIFYANPKLRLVSKKAPSLFDKEKGKAMALFMYK FT EDKVGVIFPIAGITGLGVYDAAKELGPKYYVIGLNQDQSYIAPQNVITSIIKDIGKVIY FT SISSEYINNRVFKGGIIIDRGLKEGVIEIVKDPDVLNNRLVDEVIDLENKIISGEIIVP FT DSEYAFDLFKSKL" FT -35_signal 1359..1364 FT /gene="bmpA" FT -10_signal 1382..1387 FT /gene="bmpA" FT mRNA 1393..2517 FT /gene="bmpA" FT /product="membrane lipoprotein BmpA" FT CDS 1498..2517 FT /codon_start=1 FT /transl_table=11 FT /gene="bmpA" FT /product="membrane lipoprotein BmpA" FT /db_xref="GOA:Q45010" FT /db_xref="InterPro:IPR003760" FT /db_xref="UniProtKB/Swiss-Prot:Q45010" FT /protein_id="AAC44712.1" FT /translation="MNKILLLILLESIVFLSCSGKGSLGSEIPKVSLIIDGTFDDKSFN FT ESALNGVKKVKEEFKIELVLKESSSNSYLSDLEGLKDAGSDLIWLIGYRFSDVAKVAAL FT QNPDMKYAIIDPIYSNDPIPANLVGMTFRAQEGAFLTGYIAAKLSKTGKIGFLGGIEGE FT IVDAFRYGYEAGAKYANKDIKISTQYIGSFADLEAGRSVATRMYSDEIDIIHHAAGLGG FT IGAIEVAKELGSGHYIIGVDEDQAYLAPDNVITSTTKDVGRALNIFTSNHLKTNTSEGG FT KLINYGLKEGVVGFVRNPKMISFELEKEIDNLSSKIINKEIIVPSNKESYEKFLKEFI" FT CDS 2604..3629 FT /codon_start=1 FT /transl_table=11 FT /gene="bmpB" FT /product="membrane lipoprotein BmpB" FT /note="lacks a promotor or transcriptional start site" FT /db_xref="GOA:Q45011" FT /db_xref="InterPro:IPR003760" FT /db_xref="UniProtKB/Swiss-Prot:Q45011" FT /protein_id="AAC44713.1" FT /translation="MRIVIFIFGILLTSCFSRNGIESSSKKIKISMLVDGVLDDKSFNS FT SANEALLRLKKDFPENIEEVFSCAISGVYSSYVSDLDNLKRNGSDLIWLVGYMLTDASL FT LVSSENPKISYGIIDPIYGDDVQIPENLIAVVFRVEQGAFLAGYIAAKKSFSGKIGFIG FT GMKGNIVDAFRYGYESGAKYANKDIEIISEYSNSFSDVDIGRTIASKMYSKGIDVIHFA FT AGLAGIGVIEAAKNLGDGYYVIGADQDQSYLAPKNFITSVIKNIGDALYLITGEYIKNN FT NVWEGGKVVQMGLRDGVIGLPNANEFEYIKVLERKIVNKEIIVPCNQEEYEIFIKQILK FT L" FT -35_signal 3677..3682 FT -10_signal 3697..3702 FT RBS 3729..3734 FT CDS 3742..5166 FT /codon_start=1 FT /transl_table=11 FT /product="putative protein 4" FT /db_xref="GOA:P94250" FT /db_xref="InterPro:IPR001661" FT /db_xref="UniProtKB/Swiss-Prot:P94250" FT /protein_id="AAC44714.1" FT /translation="MNKKMFPKIYYYDQDFIDIYNKSLSWIQDKVIFQKVADRTKKDKN FT YYSENCDYIDQMQACMSSFFLVYSNGEYSSTSAIDKFYQLQEESGAIRARYDNNNAIID FT LDDNEENIGFPIFAWAEYNLYHKTGNKKRISEVLPILDKYYKWIESKFLKENGLYSIDV FT NKIFYKNSPRVDAYYPIDFNSLQVHNAYCISKLADILNDKNLSLEYKKRFFSLKVKINS FT LMWSEKDGFYYDLDVNENILEIKTIVGFFPMLSEIPSEDRIERMIFYLKSTNHFGTPNP FT FPTLSVSEPGFSEDGNGYYGSVYTYMNFFVIKGLEYCGRANIAREFTIRHLYYILDTLM FT PFNKIKGHIWEAYRPMQEGPAYFDANKKTYTEKGLICYLALFSISLMIENIIGLTISLP FT DKTVYWNIPTLEIMGIESLSLKKNQTTIICNKGKRGWEIKMESEKLYYFTINILNKKEK FT TLPIPSGRCSMLLDKL" FT misc_feature 3754..3756 FT /note="potential initiation codon" FT -35_signal 5171..5176 FT /gene="mgtE" FT -10_signal 5192..5197 FT /gene="mgtE" FT RBS 5208..5213 FT /gene="mgtE" FT CDS 5220..6584 FT /codon_start=1 FT /transl_table=11 FT /gene="mgtE" FT /product="magnesium ion transporter MgtE" FT /db_xref="GOA:P94251" FT /db_xref="InterPro:IPR006668" FT /db_xref="UniProtKB/TrEMBL:P94251" FT /protein_id="AAC44715.1" FT /translation="MIDIDELRIFLKEKSYSKIKEKFLKHDSFDIAEALKRLNGTELIL FT LYRFLPKKIAVETFSNFDQSTKNKLANSFTNKEISEMIDELNLDDVIDLLEEVPANVVQ FT RFLASSTEENREIINKFLSYSDDSAGSIVTIEYVELKEDFTVGKALDYIRRVAKTKEDI FT YTYYITDDEKHLKGVIKIEDLILAKDDVILSSIMRSSGFYIVGVNDEKEDVALLFQKHD FT ITSVPVVDNEGRMIGVIIIDDILEVIQSVNTEDFQMIAAVKPLDTSYLDTSILVMTKNR FT IIWLLVLMVSSTFTATIISNYQNLMLSLVVLASFIPLLMDTSGNAGSQASALIIRELAL FT GTVKVKDFFKVFLKEICVSILVGAILASVNFLRIVFFVAPHHSDKLKIAFVVSSCLMVS FT LTVAKILGGLLPIVAKLLKLDPALMAGPLITTIADAITLIAYFNIAKWVLVSYAV" FT -35_signal 6568..6573 FT /gene="pkci" FT -10_signal 6592..6597 FT /gene="pkci" FT RBS 6623..6628 FT /gene="pkci" FT CDS 6635..7054 FT /codon_start=1 FT /transl_table=11 FT /gene="pkci" FT /product="protein kinase C1 inhibitor Pkci" FT /db_xref="GOA:P94252" FT /db_xref="HSSP:1KPF" FT /db_xref="InterPro:IPR001310" FT /db_xref="UniProtKB/Swiss-Prot:P94252" FT /protein_id="AAC44716.1" FT /translation="MYDCIFCKIINKELPSYKVYEDDLVLAFLDINPLTVGHTLVIPKE FT HSESLLNMDDKFNERVLKVCKKISNALKRINSSIYGGINIYSALGAGAGQEVFHTHFHV FT IPRFKNDGFGFKRGNKLNLEVEKFKELSMQISMNI" XX SQ Sequence 7147 BP; 2410 A; 764 C; 1333 G; 2640 T; 0 other; gtataatgaa tggtataata aaagtgcctt atgacaaggt atcttatgat aactttgttt 60 tgcaaatgga aaattaattt gatttttatt gagctgattt gtgaaaaatc tttttaattc 120 tttaaagata ttttaaaggg ttttttaatt gttgtaagtt ttgaatttaa attaatcttg 180 caaaagagtt taaatttgga tattatggtg atgtaggaaa aattgatttt tcctactact 240 gtgtttttat taatgctaga agtatttttt taaaagggat tattaaaatt ttattttata 300 aataaagaat actgcttgtt agtaaaataa agttaatatt ttaattttta aaaaatttag 360 aattttaaaa aaaaatataa ggagaggatt aattttgttt aaaagattta tttttattac 420 tttatcttta ttagtatttg cttgttttaa atctaataaa aagtctatta aatctgacaa 480 agttgttgta ggtgttttgg ctcatggtag cttttatgat aaaggctata atcaaagcgt 540 tcatgatggt gttgtaaaac ttagggataa ttttggaata aagcttataa ctaaatcttt 600 aagaccttat cctattgagg gtaaaagact tcttactgtt gatgaggcaa tgactgagga 660 tgcttatgag gttcaaaaaa atcctttaaa tcttttttgg ttgattggat accgattttc 720 tgacttgtca gttaagcttt cctatgaacg tccagatatt tattatggta ttatagatgc 780 ttttgattat ggtgatattc aagttcctaa gaattccttg gctattaagt ttagaaatga 840 agaggctgca tttttagctg ggtatattgc tgctaagatg agcagaaaag aaaagattgg 900 atttttaaca ggtcctatga gtgagcattt aaaagatttt aagtttggtt ttaaggctgg 960 aattttttat gccaatccta aattaagatt agtttcaaaa aaagcacctt ctctttttga 1020 taaggagaaa ggcaaagcaa tggctctatt catgtataaa gaagataaag taggcgttat 1080 ttttccaata gctggtataa ctggtcttgg agtttatgac gctgctaagg agcttggacc 1140 taaatattat gttattggtt taaatcaaga tcaatcatat attgcacctc aaaatgttat 1200 tacttcaata attaaggata ttggtaaggt tatttattct atttcatcag agtatattaa 1260 taatagagtt tttaagggtg gaattattat tgatcggggg ttaaaggaag gagtaataga 1320 aattgttaag gatcccgatg ttttaaacaa taggttggtt gatgaagtta ttgatctaga 1380 aaataaaata ataagtggag aaattattgt tcctgatagt gaatatgcat ttgatttatt 1440 taaatcaaag ttataaacta cttaaatata gctttgtttg taaaggggaa atagtttatg 1500 aataaaatat tgttgttgat tttgcttgag agtattgttt ttttatcttg tagtggtaaa 1560 ggtagtcttg ggagcgaaat tcctaaggta tctttaataa ttgatggaac ttttgatgat 1620 aaatctttta atgagagtgc tttaaatggc gtaaaaaaag ttaaagaaga atttaaaatt 1680 gagcttgttt taaaagaatc ctcatcaaat tcttatttat ctgatcttga agggcttaag 1740 gatgcgggct cagatttaat ttggcttatt gggtatagat ttagcgatgt ggccaaggtt 1800 gcggctcttc aaaatcccga tatgaaatat gcaattattg atcctattta ttctaacgat 1860 cctattcctg caaatttggt gggcatgacc tttagagctc aagagggtgc atttttaacg 1920 ggttatattg ctgcaaaact ttctaaaaca ggtaaaattg gatttttagg gggaatagaa 1980 ggcgagatag tagatgcttt taggtatggg tatgaagctg gtgctaagta tgctaataaa 2040 gatataaaga tatctactca gtatattggt agttttgctg accttgaagc tggtagaagc 2100 gttgcaacta gaatgtattc tgatgagata gacattattc atcatgctgc aggccttgga 2160 ggaattgggg ctattgaggt tgcaaaagaa cttggttctg ggcattacat tattggagtt 2220 gatgaagatc aagcatatct tgctcctgac aatgtaataa catctacaac taaagatgtt 2280 ggtagagctt taaatatttt tacatctaac catttaaaaa ctaatacttc cgaaggtggc 2340 aaattaataa attatggcct taaagaagga gttgtggggt ttgtaagaaa tcctaaaatg 2400 atttcctttg aacttgaaaa agaaattgac aatctttcta gcaaaataat caacaaagaa 2460 attattgttc catctaataa agaaagttat gagaagtttc ttaaagaatt tatttaaata 2520 aagaatcaat ttatatattt tatttttaag tataaaaaac acattggttt tgtttgaata 2580 attgaaatgg agaagtgctt tatatgagaa ttgtaatttt tatattcggt attttgttga 2640 cttcttgctt tagtagaaat ggaatagaat ctagttcaaa aaaaattaag atatccatgt 2700 tggtagatgg tgttcttgac gacaaatctt ttaattctag tgctaatgag gctttattac 2760 gcttgaaaaa agattttcca gaaaatattg aagaagtttt ttcttgtgct atttctggag 2820 tttattctag ttatgtttca gatcttgata atttaaaaag gaatggctca gacttgattt 2880 ggcttgtagg gtacatgctt acggatgcat ctttattggt ttcatcggag aatccaaaaa 2940 ttagctatgg aataatagat cccatttatg gtgatgatgt tcagattcct gaaaacttga 3000 ttgctgttgt tttcagagta gagcaaggtg cttttttggc tggctatatt gcagccaaaa 3060 aaagcttttc tggcaaaata ggttttatag ggggaatgaa gggtaatata gtagatgcat 3120 ttcgctatgg ttatgaatct ggagcaaagt atgctaataa agatatagag attataagtg 3180 aatattccaa ttctttttcc gatgttgata ttggtagaac catagctagt aaaatgtatt 3240 ctaaagggat agatgtaatt cattttgcag ctggtttagc aggaattggt gttattgagg 3300 cagcaaaaaa ccttggcgat ggttactatg ttattggagc cgatcaggat cagtcatatc 3360 ttgctcctaa aaattttatt acttctgtta taaaaaacat tggggacgca ttgtatttga 3420 ttactggcga atatattaaa aataataatg tttgggaagg tggaaaagtt gttcaaatgg 3480 gattaagaga tggtgttatt gggctgccta atgcgaatga atttgaatac ataaaagttc 3540 ttgagagaaa aatagtcaat aaagagatca ttgttccttg caatcaggag gaatatgaaa 3600 tttttataaa acaaatatta aagttataaa cttttgaaat agaaagattt taattttcca 3660 gtttttaatt ttttaattat gttatattta ttgtgttata ataaatagaa gtacatttct 3720 gttgttttag aggatttagc attgaataaa aaaatgtttc ccaaaattta ctattatgat 3780 caagacttta ttgatattta taataaaagt ttatcttgga ttcaagataa ggtgattttc 3840 caaaaagttg ctgataggac caaaaaagat aaaaattatt attcggaaaa ttgtgattat 3900 atagatcaga tgcaagcttg tatgtcaagc ttttttcttg tctatagtaa cggggaatat 3960 tcatctacat ctgcaattga taaattttat caattgcagg aagaatctgg tgcaatcagg 4020 gctagatatg acaataacaa tgctattatt gatcttgatg ataatgaaga gaatattgga 4080 tttcctattt ttgcatgggc tgaatacaac ttatatcata agacaggaaa taaaaagaga 4140 atttctgaag ttttaccaat tcttgataag tattataaat ggatagagag caaattttta 4200 aaggaaaatg gtctttattc aattgatgta aataaaattt tttataagaa ctccccaaga 4260 gtagatgcgt actatccaat agattttaat tcattgcaag ttcataatgc atattgtatt 4320 tctaaattgg cagacatttt aaatgataaa aatttatcgc ttgaatacaa aaaacgattt 4380 ttttccctta aggtcaaaat taattcttta atgtggagcg aaaaagatgg attttattat 4440 gatcttgatg ttaatgaaaa tattcttgaa atcaagacaa tagtaggttt tttcccaatg 4500 ctttctgaga ttcctagtga ggacagaata gaaagaatga ttttttattt aaaaagtact 4560 aatcattttg ggactccaaa tccttttcca acactttctg ttagtgagcc aggttttagt 4620 gaggatggca atggatatta tggttcagtt tatacttata tgaatttttt tgtaatcaaa 4680 gggcttgaat attgtggtcg tgcaaatatt gcaagagaat ttactataag acatttgtat 4740 tatatattag atactttaat gccttttaat aaaattaagg ggcacatttg ggaagcttat 4800 agacctatgc aagaaggacc tgcatatttt gatgctaata aaaaaactta taccgagaaa 4860 ggtcttattt gttatcttgc actttttagt attagcttaa tgatagaaaa tattattggg 4920 cttacaatta gtttgcctga taaaactgta tattggaaca tacccactct tgagattatg 4980 gggatagaaa gcttatctct taaaaagaat caaactacaa taatttgcaa taaagggaaa 5040 agaggttggg agataaaaat ggaatctgaa aaactttatt attttacaat aaatatatta 5100 aataaaaaag aaaaaaccct tcctattcct tcaggaagat gttctatgtt attggataag 5160 ctttgatgaa ttagattcat taaatgtctt gtaaaattta aatttttgga ggccttttaa 5220 tgatagatat cgatgagttg agaatttttc ttaaagagaa gagctattct aaaattaaag 5280 aaaaattttt aaagcatgat tcctttgata ttgctgaggc tcttaaaaga cttaatggaa 5340 ctgaattgat tttgctctac agatttttgc ccaaaaaaat agcagttgaa actttttcta 5400 attttgacca atctacaaaa aataaattag caaattcttt taccaataaa gaaataagtg 5460 aaatgattga tgagctgaat cttgatgatg ttattgacct tttggaagag gttcctgcaa 5520 atgttgttca gagatttttg gcaagttcta cagaagagaa tagagaaatt attaataaat 5580 ttttgtctta cagtgatgat tctgcaggtt cgatcgtaac aattgagtat gttgagctta 5640 aagaagattt cacggttggc aaagctcttg attatattag aagggtagct aaaaccaaag 5700 aagatattta cacttattat attacagatg atgaaaagca tttaaaagga gttataaaaa 5760 ttgaagattt aatattggct aaagatgatg ttattctctc gtcaataatg agaagtagtg 5820 ggttttatat tgtgggggtt aatgatgaga aagaagatgt tgcacttctt tttcaaaaac 5880 atgatattac cagtgttcct gttgttgata atgaggggag aatgataggg gttattatta 5940 ttgatgacat tttagaggtt attcaatctg taaatactga agattttcaa atgattgcag 6000 ctgttaagcc tttagataca tcttatcttg atacttctat tttagttatg acaaaaaata 6060 gaataatttg gcttttagtt cttatggtgt cttctacttt tacagctaca attatttcaa 6120 attatcaaaa tttaatgttg tctttagtgg ttttagctag ttttattccc cttttaatgg 6180 atacttcagg caatgccggc tctcaggcat ctgcgttaat aattcgtgag cttgctcttg 6240 gtactgtcaa ggtaaaagat ttttttaaag tgtttttaaa ggaaatatgt gttagtattc 6300 tagtgggagc aattcttgct agtgttaatt ttttaagaat tgtctttttt gtagctccac 6360 accattctga taagctgaaa atagcttttg tagtttcatc ttgcttgatg gtaagtttga 6420 cagtagcaaa gatattggga ggtcttttac ccattgttgc taaactttta aagttggatc 6480 cagcacttat ggcaggccct ttaatcacta caattgcaga tgctattact ttaatagctt 6540 attttaatat agcaaaatgg gttttagtta gctatgctgt ttaagtttca tttaaatata 6600 ttgattgcta tttttttata ataggatatt tttaatgtat gattgtattt tttgtaaaat 6660 aataaacaaa gagcttccta gttataaagt ttatgaggac gatttagttt tagcattttt 6720 agatattaat cctttaactg ttgggcatac tcttgttatt cccaaagaac atagtgagag 6780 tttattaaac atggatgata aatttaacga gagagtttta aaggtatgta aaaaaatttc 6840 aaatgcttta aaaagaataa actcaagcat ttatggtgga ataaatattt attctgcttt 6900 gggggctggc gcagggcaag aggtttttca tactcatttt catgtaattc caagatttaa 6960 aaacgatggt tttggtttta agagaggcaa taaacttaat cttgaagttg aaaaatttaa 7020 agagttgtct atgcaaataa gtatgaatat ttaattttat tttgtccaaa aggattcttt 7080 gtgagaagaa actttttatt cttttttgtt tttatgctta atgcatttag aatttattca 7140 ggaattc 7147 // |
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