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EBI DbfetchID U29536; SV 2; linear; genomic DNA; STD; INV; 14741 BP. XX AC U29536; XX DT 23-JUN-1995 (Rel. 44, Created) DT 31-AUG-2005 (Rel. 85, Last updated, Version 65) XX DE Caenorhabditis elegans cosmid F45E12, complete sequence. XX KW HTG. XX OS Caenorhabditis elegans OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. XX RN [1] RP 1-14741 RX DOI; 10.1126/science.282.5396.2012 RX PUBMED; 9851916. RG C. elegans Sequencing Consortium RA ; RT "Genome sequence of the nematode C. elegans: a platform for investigating RT biology"; RL Science 282(5396):2012-2018(1998). XX RN [2] RP 1-14741 RA Latreille P.; RT "The sequence of C. elegans cosmid F45E12"; RL Unpublished. XX RN [3] RP 1-14741 RA Waterston R.; RT ; RL Submitted (19-JUN-1995) to the EMBL/GenBank/DDBJ databases. RL Department of Genetics, Washington University, Genome Sequencing Center, RL 4444 Forest Park Avenue, St. Louis, MO 63110, USA XX RN [4] RP 1-14741 RA Waterston R.; RT ; RL Submitted (22-MAY-2002) to the EMBL/GenBank/DDBJ databases. RL Department of Genetics, Washington University, Genome Sequencing Center, RL 4444 Forest Park Avenue, St. Louis, MO 63110, USA XX RN [5] RP 1-14741 RA Waterston R.; RT ; RL Submitted (29-OCT-2002) to the EMBL/GenBank/DDBJ databases. RL Department of Genetics, Washington University, Genome Sequencing Center, RL 4444 Forest Park Avenue, St. Louis, MO 63110, USA XX RN [6] RP 1-14741 RA Waterston R.; RT ; RL Submitted (19-NOV-2002) to the EMBL/GenBank/DDBJ databases. RL Department of Genetics, Washington University, Genome Sequencing Center, RL 4444 Forest Park Avenue, St. Louis, MO 63110, USA XX RN [7] RP 1-14741 RA Wilson R.; RT ; RL Submitted (05-APR-2004) to the EMBL/GenBank/DDBJ databases. RL Department of Genetics, Washington University, Genome Sequencing Center, RL 4444 Forest Park Avenue, St. Louis, MO 63110, USA XX RN [8] RP 1-14741 RG WormBase Consortium RA ; RT ; RL Submitted (21-SEP-2004) to the EMBL/GenBank/DDBJ databases. RL Department of Genetics, Washington University, Genome Sequencing Center, RL 4444 Forest Park Avenue, St. Louis, MO 63110, USA XX RN [9] RP 1-14741 RG WormBase Consortium RA ; RT ; RL Submitted (30-AUG-2005) to the EMBL/GenBank/DDBJ databases. RL Department of Genetics, Washington University, Genome Sequencing Center, RL 4444 Forest Park Avenue, St. Louis, MO 63110, USA XX DR EMBL-CON; BX284602. XX CC On Apr 5, 2004 this sequence version replaced gi:868261. CC Submitted by: CC Genome Sequencing Center CC Department of Genetics, Washington University CC St. Louis , MO 63110, USA, and CC Sanger Centre, Hinxton Hall CC Cambridge CB10 IRQ, England CC email: submissions@watson.wustl.edu and jes@sanger.ac.uk CC NOTICE: This sequence may not be the entire insert of this clone. CC It may be shorter because we only sequence overlapping sections CC once, or longer because we provide a small overlap between CC neighboring submissions. CC This sequence was finished as follows unless otherwise noted: all CC regions were double stranded, sequenced with an alternate chemistry CC or covered by high quality data (i.e., phred quality >= 30); an CC attempt was made to resolve all sequencing problems, such as CC compressions and repeats; all regions were covered by sequence from CC more than one m13 subclone. CC For a graphical representation of this clone sequence and its CC analysis see: CC http://www.wormbase.org/db/seq/sequence?name=F45E12;class=Sequence CC NEIGHBORING CLONE INFORMATION CC The 5' clone is C30G12, 800 bp overlap; the 3' clone is F21D12, 200 CC bp overlap. Actual start of this clone is at base position 31112 of CC C30G12; actual end is at 12725 of F21D12. CC NOTES: CC Coding seqences below are the result of integration and manual CC review of the following data : computer analysis using the program CC Genefinder (P. Green and L. Hillier, personal communication), the CC large scale EST projects of Yuji Kohara CC (http://www.ddbj.nig.ac.jp/c-elegans/html/CE_INDEX.html) and The C. CC elegans ORFeome cloning project (http://worfdb.dfci.harvard.edu/), CC similarity to other proteins from BlastX analyses CC (http://blast.wustl.edu/), sequence conservation with C. briggsae CC using Jim Kent's WABA alignment program (Genome Research CC 10:1115-1125, 2000), individual C. elegans GenBank submissions, CC and personal communications with C. elegans researchers. tRNAs CC are predicted using the program tRNAscan-SE (Lowe, T.M. and CC Eddy, S.R., 1997, Nucl. Acids. Res., 25, 955-964). XX FH Key Location/Qualifiers FH FT source 1..14741 FT /organism="Caenorhabditis elegans" FT /chromosome="1" FT /strain="Bristol N2" FT /mol_type="genomic DNA" FT /clone="F45E12" FT /db_xref="taxon:6239" FT gene 1197..4616 FT /gene="cul-4" FT /locus_tag="F45E12.3" FT CDS join(1197..1298,1345..1452,1499..1577,1619..1666, FT 1712..1815,1863..2054,2101..2433,2488..2848,2933..3043, FT 3090..3308,3355..3863,3909..4156,4508..4616) FT /codon_start=1 FT /gene="cul-4" FT /locus_tag="F45E12.3" FT /standard_name="F45E12.3" FT /product="Cullin protein 4" FT /note="contains similarity to Pfam domain PF00888 (Cullin FT family); coded for by the following C. elegans cDNAs: FT yk15c1.3, yk15c1.5, yk34c8.3, yk34c8.5, yk36e6.3, yk36e6.5, FT yk44e11.3, yk44e11.5, yk508g4.3, yk508g4.5, yk827g12.3, FT yk827g12.5, yk1143a05.3, yk1143a05.5, yk1228d05.5, U58086, FT yk1554d03.3, yk1554d03.5, yk1688h09.3, yk1688h09.5" FT /db_xref="GOA:Q17392" FT /db_xref="InterPro:IPR011991" FT /db_xref="UniProtKB/Swiss-Prot:Q17392" FT /db_xref="WormBase:WBGene00000839" FT /protein_id="AAA68791.3" FT /translation="MTSGAPPTISTEKSRSKQLRKSSKRTASTVEGTEAKQMRGDTENR FT SDGEMDDVSTSSEIRHGNGFIENFRSQTGNSSRTTATNERIKKKLVIKNFKANANQNDV FT AMGDTNIDSTDGSVGRDWAVLSDNVFAILEDRKTVTTLEGLFSKVRSVCDKNQSKVLYD FT RLVAIVVQFAKSLKESLNAVEQVPLAEDNCEQYLEKFGQIWQAYPVKINLIRNIFLHLD FT RIALGATDTEILPLWECFMQIFQKTFFPNIFKEFKATKLFNALYMAMQKIMQRYPVDSP FT LRSLVDMLQTVHVSEEFAKFLISQLREHYNNERIDKVPKMNCNDYMEYCEDQINRYSQL FT VKVNFDEPSALKDVQATVTNCLIQQAIPEILTHDFDDLIDSDNISDIGRMFNLCRQCVG FT GEDEVRTQFSKYLKKRGEKLIATCPDEDLVSELLAFKKKVDFIMTGSFKSANDPVKMRQ FT CLSDAFESFVNKQVDRSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRYLRGK FT DVFEAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYG FT RLFNQYLEHMNKEKANFTARVITPEYWPTYDTYEINIPKEMRDTLTDYQDFYRVQHGNR FT NVKWHHGLASAVISASFRPGCKKELIATMYQTVILLLFNKCETWTVAEIVEHTKILEIE FT VVKNVLALLGGRDKPKVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRIAQV FT NIKTAVEETKEVKEEVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELLQQLRFPVSTAD FT IKKRLESLIEREYISRDPEEASSYNYVA" FT misc_feature 4946..4947 FT /note="SL2 trans-splice acceptor; see yk1413c02.5" FT gene 4957..7514 FT /gene="brf-1" FT /locus_tag="F45E12.2" FT CDS join(4957..5119,5165..5457,5504..6222,6277..7051, FT 7097..7219,7264..7383,7428..7514) FT /codon_start=1 FT /gene="brf-1" FT /locus_tag="F45E12.2" FT /standard_name="F45E12.2" FT /product="Brf (transcription factor) homolog protein 1" FT /note="contains similarity to Pfam domains PF07741 FT (Brf1-like TBP-binding domain), PF00382 (Transcription FT factor TFIIB repeat); coded for by the following C. elegans FT cDNAs: OSTF005H2_1, OSTF005H2_2, OSTR005H2_1, yk126e2.3, FT yk126e2.5, yk182e6.5, yk275d12.3, yk275d12.5, yk281d12.3, FT yk281d12.5, yk395h5.3, yk395h5.5, yk447g12.3, yk447g12.5, FT yk1413c02.3, yk1413c02.5" FT /db_xref="GOA:Q20429" FT /db_xref="InterPro:IPR013763" FT /db_xref="UniProtKB/TrEMBL:Q20429" FT /db_xref="WormBase:WBGene00000271" FT /protein_id="AAA68790.1" FT /translation="MVRTCSNCGSSEIDEDAARGDATCTACGTVLEESIVVTENQFQER FT AGGSGHTLVGQFVSSERAAANNFNGMGSQESREMTYAKGRKVIDELGSQLRINSHCMNT FT AFNFYKMCVSRNLTRGRNRSSVVAVCMYITCRLENTAHLLLDFSDVTQINVFDLGRNLN FT YLSRSLRINLPSTDPCLYIMRFACVLDFGDKQKEVVNLATRLVQRMKRDWMSTGRRPTG FT ICGAALLIAARSLNFNRSINDIVRVVHISEGVIRKRLDEFSQTPSGSLTIDEFSTVDLE FT HSEDPPAYRESRRKAREDQLRKEAEQAESMKEQLGEMEAHVEAALDKKRKEKFSKSPYA FT RMISENLGKENDKMQTLTETVVESSGLEKGADEMVRNEIINTVFNAAEEDPCTSNSLEK FT YDKYRPSLESLGIKRTSEPEPEPVPHPIVNADLEEDISDSEIDSYILTESEVAIKTDYW FT MKANGEAMKEIEEKKRERELNGGVKKKKPRSNRKTDTTSTSVASAVEKVIAEKKLSNKV FT NYEMLKDLETMATGIKRDIRESTPAPVTPISIKVDSSDVTPDTLSKSEKIARGKNIRSQ FT ASESTIQKLRSIFDLTEECSETSKNSSPKVNLKVESASPSTSEVSSIEHKPFVPPARSR FT YAKVKPIIGAKKLAALNEVKNVHTVPEPSAPAEPIVSEAPLQVKTSSSDPIVTSTEVPS FT VAEPPAPIQNVEEAKPIVPVKSRYAKAKPNLKPIKQKTAVDVVTVGEGESSEPSAKRTK FT AEHLES" FT gene complement(7853..9188) FT /locus_tag="F45E12.5" FT CDS complement(join(7853..8089,8139..8328,9076..9188)) FT /codon_start=1 FT /locus_tag="F45E12.5" FT /standard_name="F45E12.5b" FT /product="Hypothetical protein F45E12.5b" FT /note="contains similarity to Pfam domain PF00238 FT (Ribosomal protein L14p/L23e); coded for by the following FT C. elegans cDNAs: OSTF096B11_1, OSTR096B11_1, yk1352c05.3, FT yk1352c05.5" FT /db_xref="GOA:Q20430" FT /db_xref="InterPro:IPR000218" FT /db_xref="UniProtKB/TrEMBL:Q20430" FT /db_xref="WormBase:WBGene00018475" FT /protein_id="AAA68795.2" FT /translation="MANLPSSSGMFSRLLANVFNTTVASRCSASGRWWPQPEYELSKHR FT SRAPSMGIHRRTRLNVVDNSALGKEADTTGKLPYCIHVYKQGRRAKHMPHAELGDKILV FT AIRGQMRKAYVVGANTHVHYRKHGVPVTDQNMIVLLDEEGNPLGNRITAPIPTKLMANR FT GNVQFSKVLALANKFI" FT CDS complement(join(8442..8922,9076..9188)) FT /codon_start=1 FT /locus_tag="F45E12.5" FT /standard_name="F45E12.5a" FT /product="Hypothetical protein F45E12.5a" FT /note="contains similarity to Ashbya gossypii AGR327Cp.; FT TR:Q74Z79; coded for by the following C. elegans cDNAs: FT OSTF114G6_1, OSTR114G6_1, yk303e8.5, yk303e8.3" FT /db_xref="GOA:Q20431" FT /db_xref="UniProtKB/TrEMBL:Q20431" FT /db_xref="WormBase:WBGene00018475" FT /protein_id="AAA68792.1" FT /translation="MANLPSSSGMFSRLLANVFNTTVASRCSASGRWWPQPDRRFTTKS FT DEKSSLEPKNTNETDVIITQQGVKLSKSNAAPVYYKPKSTGPGYELVEHKKGEMIANYT FT LFEAAINKSKVPWVNYDGLTSEERTIHMAHTRAINDRKLTYIDPKTGYSVFTISHHLQK FT GKCCGNGCRHCAYEMINASDEIRSQKVWNGAFYV" FT misc_feature complement(9190..9191) FT /note="SL1 trans-splice acceptor; see yk1352c05.3" FT gene 10602..12342 FT /locus_tag="F45E12.1" FT CDS join(10602..10688,10735..10804,11185..11303,11351..11433, FT 11480..11572,11928..12052,12179..12342) FT /codon_start=1 FT /locus_tag="F45E12.1" FT /standard_name="F45E12.1" FT /product="Hypothetical protein F45E12.1" FT /note="contains similarity to Pfam domain PF03031 (NLI FT interacting factor-like phosphatase); coded for by the FT following C. elegans cDNAs: OSTF101E1_1, OSTR101E1_1, FT yk1302b01.3, yk1302b01.5" FT /db_xref="GOA:Q20432" FT /db_xref="InterPro:IPR004274" FT /db_xref="UniProtKB/Swiss-Prot:Q20432" FT /db_xref="WormBase:WBGene00018474" FT /protein_id="AAA68794.1" FT /translation="MTTIAQSVFCFLAGFFNFFLLYFRKTSRAYCKYQVVKYHSNIPMS FT PLTTHRLLTVKRKILVLDLDETLIHSHHDGVLRQTVKPGTPSDFTIRVVIDRHPVKFSV FT HERPHVDYFLSVVSQWYELVVFTASMEVYGTSVADRLDRGRGILKRRYFRQHCTMEVGG FT YTKDLSAIHPDLSSICILDNSPGAYRKFPHNAIPIPSWFSDPNDTCLLNLLPFLDALRF FT TSDVRSVLSRNMQALPETQSVQYY" FT gene complement(12997..13253) FT /locus_tag="F45E12.6" FT CDS complement(join(12997..13060,13114..13253)) FT /codon_start=1 FT /locus_tag="F45E12.6" FT /standard_name="F45E12.6" FT /product="Hypothetical protein F45E12.6" FT /note="contains similarity to Methanococcus jannaschii FT Hypothetical UPF0131 protein MJ1514.; SW:Q58909" FT /db_xref="UniProtKB/TrEMBL:Q20433" FT /db_xref="WormBase:WBGene00018476" FT /protein_id="AAA68793.1" FT /translation="MYVIRALILLLTIYISTSSAFPSPLVNRESRALAPSVESWCIFYP FT EKCRMLRFAGTHKRNMMEDFEY" XX SQ Sequence 14741 BP; 4844 A; 2587 C; 2588 G; 4722 T; 0 other; ataaattaag ttaacatccg attaaagctg tcaattttca gccattccaa caactaccac 60 aactccaaga caaatatcac ttcaaacgat tccattttca accacaacta gacaaccaaa 120 ttttgataaa accaagactc ctgcaacaat gccatcagct tcttcttctt cactttcaag 180 tattcaaaca gttgttgatc caattatctt gaagttaatt tcaaaggcat tggaaaaaaa 240 tgaaatgatt gatgaatatt cattgaaaca ggctctatcg atgagaaatg ttgcaactac 300 tactgtaggt ttaaatcttt aatacatctg aattatcaat tatttcagac tcctcttcca 360 cttcgtttca ttcttccaac acctgcagcc ccaaatccat ttctaccgtc tacaagagtt 420 ggaggtcttt ctcataatca tctattcatt ccccatcaac cgtttactac tcttgtttcg 480 accgattcta gatattctgc accgaaccct ctttctcatc gacttccaaa cgagatttgc 540 cgagttcata tgaattcaaa tcctttccat ttttagtttt attactctac caaataatta 600 aacagacttt tcctatcggg tcccctaatt ttctttcatt tttcaggcat ctcggttgtt 660 tttttcaaag tattttgacc taattttcca tgttgaaatt aataaaatat ttattaaatg 720 aacacaaaca cagatgttgg aattgtcttc ttctggtcaa gtactggata tactctcttt 780 ttttgataat gctgaattga taaatttttg gttccaatga aaggatcaaa cattgtagaa 840 aatctttaca aaaataattg tagacctact attataataa atacagtttt atgcagagtc 900 tgcgtctctc aatatgaaca gcctctcaag cactagagat gcgccagcac gccgcgcgtc 960 agcaaacgtc tttggcctca gtttgccttc aaaataatgc atgagttcgg catttcaaat 1020 attatttaag ccaaattgtt tttctaaact gcggaaatct aattttgaga aaaggaaatt 1080 ttaaatccaa tcgttttatt ttaatcttaa aatatctttc tatataaaac cgccaaccgt 1140 cctgtttgtt tcttcagaga tactaataat ctaacatttt caacagaaca aattggatga 1200 catctggagc accaccgact atttcaacag aaaaaagtcg aagtaaacag cttcgaaaat 1260 cgtcaaagcg cacagccagc accgttgaag gtacagaggt agtaattaaa taatattttc 1320 aatgtgagaa aaaataaatt gcaggctaag caaatgcgcg gcgacactga aaatcgttcc 1380 gacggagaaa tggacgatgt ttcaacaagc agcgaaatca gacatggaaa tggatttatt 1440 gagaatttca gagtgagtta ttaatttatt aaaatgttca tcggtgggaa gttttcagag 1500 tcaaaccggc aattcttcac gcacaaccgc aacaaatgaa cgcatcaaaa agaaacttgt 1560 gataaagaac tttaaaggta atatttgtaa agttttcatt agttattttg atttccagcg 1620 aacgcgaatc aaaatgatgt tgcgatgggg gacaccaata ttgatagtaa gtttattctt 1680 cgataggtgt tatattttgt ttgatatcca ggtacagacg gatcagttgg tagagattgg 1740 gctgttcttt cggataatgt tttcgctatt cttgaagata ggaaaacagt aaccactttg 1800 gaaggcttat tcagcgtaag tttttgattg tttaaaacat tgtaaaaact gagcgttttc 1860 agaaggtcag atctgtgtgc gataaaaatc aatcaaaagt actttacgat cgtctcgttg 1920 caattgttgt tcagtttgca aaatcattaa aggagtcgtt aaatgcggtt gagcaagttc 1980 ctcttgcaga agacaattgt gagcaatatt tggaaaagtt tgggcagatc tggcaagcat 2040 atccagttaa aatcgtaagt gaagagtttt atttaaaaaa aaacaataga tttaactcag 2100 aatctcatca ggaatatttt tcttcatctg gaccgaattg cgctcggcgc tacagacaca 2160 gaaattctcc ctttgtggga atgtttcatg caaatatttc aaaaaacatt cttcccgaac 2220 attttcaagg aattcaaagc aacaaaactg ttcaatgctc tctatatggc gatgcagaaa 2280 attatgcaga ggtatccagt ggacagtcct ctcagaagtc ttgtagatat gcttcaaaca 2340 gttcatgtgt ctgaagaatt tgcaaaattc cttattagcc aacttcgaga gcactataac 2400 aatgagagaa tcgataaagt tccaaaaatg aatgtaggtt tttattttca ttctttgaaa 2460 aatctcgatt acttatattt attttagtgc aacgattaca tggaatactg tgaagaccag 2520 ataaatcgat attcgcaatt agtgaaagtg aactttgatg aaccgtcggc tctaaaagat 2580 gttcaggcaa cagtgacaaa ctgtctcatt caacaagcaa ttcctgaaat tctcacacat 2640 gattttgacg atcttatcga ttctgataac atttcggata tcggccgaat gtttaatttg 2700 tgccgtcaat gcgttggtgg agaggatgaa gtacgtacac aattctcaaa gtatttgaaa 2760 aaacgcggag agaaattgat tgctacgtgt cctgatgaag atcttgtttc tgagctactt 2820 gctttcaaga agaaagttga ttttatcagt aagtatttca aagttctctg ttatttttat 2880 tattatcaaa aattttaaat tcctcatacg tggatcatta atcatatttc agtgactgga 2940 agcttcaaat ccgcaaatga tccagtaaaa atgagacaat gtttgtcaga tgcctttgaa 3000 tcttttgtaa ataaacaagt cgatcgatct gcagaactta tttgtaagtc ataattcgaa 3060 atttctatat tataatttct atttttcagc aaagcacttc cacacacttc ttcacagtag 3120 caataaaaat gtatcagacg acacaactct cgatcaaatg gtagatgaag ctattgtgtt 3180 gttccgatat cttcgtggaa aagacgtttt tgaagcatat tataaaagag gtcttgctaa 3240 gcggcttttc cttgaaagaa gtgcatctgt tgatgctgaa aagatggttt tatgcaagtt 3300 aaagacaggt atttaatact ttttagtttt caaattaata actttttgat ttagagtgtg 3360 gctcggcgtt cacatacaaa ttggaaggaa tgttcaaaga tatggatgca tctgaaaatt 3420 atggaagatt attcaaccaa tatctagaac atatgaacaa agaaaaagcg aatttcactg 3480 ctcgagtcat aactccagaa tattggccaa cctatgacac atatgaaatt aatattccaa 3540 aagagatgag agatacactt accgattatc aagattttta ccgtgttcaa catggaaatc 3600 ggaatgttaa atggcatcac ggactggctt ctgcggttat ttctgcttca ttcaggcctg 3660 gatgtaagaa agaattaatt gcaacaatgt atcaaactgt cattcttctt cttttcaaca 3720 aatgtgagac atggactgtc gctgaaattg ttgagcacac taagattctg gaaattgaag 3780 tcgtcaaaaa tgtgcttgca cttcttggtg gacgtgataa gcctaaggtt ttgcagagag 3840 tcgaaggagg tggatccgaa aaggtaacta acttttcatt caactcaact aaaaatgtct 3900 ttgtttagaa ggaaggtact gtggaaaatt tgaaaaacga gaaatttgtt gtaaattcta 3960 aattcacgga gaagcgctgc cgagttagga ttgctcaggt caatataaag acagctgtgg 4020 aagagacgaa ggaagtgaaa gaagaagtga attctgatcg acaatacaaa attgacgctg 4080 ctgttgtaag aattatgaag gctcgaaagc agctaaacca tcaaactcta atgacggagt 4140 tattgcaaca attgaggtaa gttttcagaa aaaaaacttt atttttaaat tcaaaaaatt 4200 caatcaattt tttattcgag aaatagtaat atcaatataa gccgaaaaat aaaaactggt 4260 tttgaaattt tttatgaaaa tattgaatgt aaaatataaa ttggcacaca actacaaacc 4320 aaaatcaaag gaaatgtaaa aattgagaac tttttcaata ctctcaaaaa catagcattt 4380 agtaaattaa tatgaatttt gacattttga agcgatttcc ttgataaaaa tttgtctaaa 4440 ttttgctaaa tttgctgcta aggtaaaata aatgttaatt attctaaatg agtttttttt 4500 gtttcagatt ccccgtgagc accgccgata tcaagaaacg cctggaatca ctcatcgaac 4560 gtgaatatat atcgagggat cctgaagagg catctagcta taattatgtt gcgtaataca 4620 taatatcatt tttattcctt tttcaaattc aatccttatc cgtgccactg gtctcttctc 4680 atctcgtttg ccctgttatt gaacagtttt cttcctttat ttgtgcgagt ttcgtctttt 4740 ttagagaaaa atgtactaaa tgttagtttc tgttttttca attatgtttt tctcttcacc 4800 taacatgtgc atccaaaata ctgttgaata catggttatt tgattgaatt ctttatacga 4860 aattactcga atcggttgaa atatccgtga tcttacattt ttttggtttt ttttttctta 4920 atcaattttc aaagtttctc gttaagcaga cacaaaatgg ttcgaacctg ctcgaactgc 4980 ggaagttctg aaattgatga ggatgctgct agaggagatg ctacgtgcac tgcgtgcgga 5040 actgtgctcg aagaatccat tgtcgtaact gaaaatcaat ttcaagagcg agctggtgga 5100 tcaggtcaca ctctagtcgg tatgtggtag gaatgttaaa agtatttaca aaatgttatt 5160 tcaggtcaat ttgtgtcctc agagcgagct gcagctaaca atttcaatgg aatgggatct 5220 caagaatctc gagaaatgac gtatgcaaaa ggccggaaag ttattgatga gctcggcagt 5280 cagttacgaa taaattcaca ttgtatgaac actgcattca atttttacaa aatgtgcgta 5340 tctcgtaacc tgacacgtgg acgtaataga tcatccgttg ttgctgtttg catgtatata 5400 acttgtcgac tagaaaacac tgctcatttg ttgctcgatt tcagtgatgt cactcaggta 5460 tgacatttcg gtaaactttt gtaattaata agtgcaattt cagattaatg tcttcgattt 5520 gggaagaaac ttgaactacc tttctcgttc attgcgtatc aatctcccat ccacggatcc 5580 ttgtctttac attatgcgat tcgcatgtgt tttggatttt ggcgacaaac agaaagaagt 5640 tgtgaatttg gcgacaagac tagtacaaag aatgaaaaga gattggatgt ctactggaag 5700 aagaccaact ggaatctgtg gagctgctct tttaattgct gcaagatctc ttaatttcaa 5760 tcgatccatt aatgatatcg ttcgtgttgt acacatcagt gaaggcgtaa tcagaaaacg 5820 tctcgatgaa ttcagtcaaa ccccttcggg aagtcttacg attgatgagt tttcaactgt 5880 tgatctagaa catagtgaag atccaccagc atatcgagaa tcacgacgga aagcacgtga 5940 ggatcaattg agaaaagagg ctgagcaagc agaatcaatg aaagaacaac taggagaaat 6000 ggaagctcac gttgaagctg cactcgataa gaagaggaag gaaaagtttt caaaaagtcc 6060 atatgcacga atgattagtg aaaatctagg taaggaaaat gataaaatgc agacgcttac 6120 tgaaacagtt gtggagagtt cagggttgga aaaaggagct gatgaaatgg tacgaaatga 6180 aattatcaat acagttttca acgctgctga agaagatcct tggtgagttt tctttgtatt 6240 tttaactcta ggtttgttta aatattgtaa ttacagcacc tcgaactcat tggaaaaata 6300 tgataagtat cgtccttcgc tggaatctct tggaataaaa agaacatcgg agccagaacc 6360 cgaacccgtc ccacatccaa tagttaatgc cgatttagaa gaagacatct cagattcaga 6420 aatcgattcg tacattctga cggaaagtga agtagccatc aaaacagatt attggatgaa 6480 agcaaatgga gaagcaatga aagagattga agagaagaaa cgcgaacgtg aattgaatgg 6540 tggagtaaag aagaagaaac cgagatccaa tcgaaaaact gacaccacgt ctacatctgt 6600 tgctagtgcc gttgagaaag ttattgcgga gaagaaatta tcgaataaag tgaactacga 6660 gatgttaaaa gatttggaga cgatggcgac tggtatcaag agagatatac gtgaatcaac 6720 tccggctcca gtcactccaa tttcaatcaa agttgattcg tctgacgtca ctcccgatac 6780 cttatctaaa agtgaaaaaa tagcgagagg taaaaatata cgatctcaag ccagcgaatc 6840 gacaatccaa aagttgagaa gtatttttga tctgacagaa gaatgctctg aaactagcaa 6900 aaactcatca ccgaaggtta atttgaaagt tgaatctgct agtccatcaa cttctgaagt 6960 atcttcaatc gaacataaac cgtttgtacc acccgctaga tccagatatg ccaaagtgaa 7020 gccgattatt ggagctaaaa agcttgcagc tgtgagttca actgtagccc atttagattt 7080 tattttaaaa tttcagctaa acgaagtcaa aaatgtccat acagttcctg aaccatctgc 7140 accagcggag ccaatcgttt ctgaagcacc tctacaagta aaaacatcat cttctgatcc 7200 tatcgttacg agcacagagg ttttaacaaa tttttagttt agtcaatcgt tgattaattt 7260 caggtgccat ccgtcgctga gccaccagct ccaattcaaa atgtagaaga agcaaaacca 7320 attgttcccg tcaaatcaag atatgcaaaa gcaaaaccaa atttgaaacc gataaagcag 7380 aaggttacct ttaatctgcc aataaaaaaa tactgaaatt tttccagact gccgtcgacg 7440 ttgtcactgt cggagaggga gaatccagtg aaccatcggc caagcgcact aaagcagagc 7500 atcttgaatc ctaatttgaa ctatcttgca acaatcctcc attaaacaat ttattagcca 7560 ctaaaactgc actctccccg ctctagttat ttcgacttcc tttttatgaa aatacaggtt 7620 aatttttttc taacacgaat cgttctcagg cttccacttt ctcaattatt gtttccttca 7680 gttgttctgc gttcaaaatt tgttcagttc ttcgactttc aaatttcgaa tgctgttgtt 7740 gtttctatta tatccattct gtatatgttt aattaaacta aatttttctc gttttgattt 7800 atctataaag taacaagcaa aaacaatcta tggctaagaa catttttaaa ttttagataa 7860 acttgttcgc caatgcaaga actttcgaaa actgcacatt tccacgattg gccatgagtt 7920 ttgtgggaat gggagcggtg attcggtttc cgagtggatt tccttcttca tcgagaagca 7980 caatcatatt ctgatcagta actggaactc catgttttcg gtagtggacg tgcgtatttg 8040 caccgaccac gtaagctttt cgcatttgtc cacggatggc aacgagaatc taaacacatt 8100 tatattaggt aaatcaaggg aaaaaacaac agaaatacct tgtcaccgag ttctgcgtgt 8160 ggcatatgct tggctcgtct tccttgcttg tatacgtgaa tgcagtacgg tagttttcca 8220 gtcgtatctg cttcttttcc gagagcagag ttatcaacaa cattcaggcg tgttcttcgg 8280 tggattccca tgctcggagc tctgcttcga tgtttcgaca actcatatct gtataaaaaa 8340 tgtattttcc tgaattaatt tctaaaacaa aacggtcaca gcgttcagaa agcaaatttt 8400 attttaataa aaactaaaat agctaatcaa ctaatcaaca gtcaaacata aaatgctcca 8460 ttccacactt tttgtgatcg tatttcatct gatgcgttaa tcatttcgta tgcacaatgc 8520 cggcatccgt ttccacaaca ctttcctttt tgcaaatgat gggaaattgt gaacacagaa 8580 tatccagttt ttggatcgat ataagtgagt tttctgtcat taatggctct cgtatgtgcc 8640 atatgaatag ttctttcttc acttgtgagt ccatcgtagt tcacccatgg aactttagat 8700 ttgttgattg cagcttcgaa gagagtatag tttgcgatca tttctccttt cttgtgctcc 8760 acgagctcat aacctggacc cgttgatttt ggtttataat aaactggagc agcattagat 8820 tttgatagtt taacaccttg ttgagtgata atgacatcag tttcgtttgt gttcttgggc 8880 tcaagggatg atttttcgtc cgatttcgtg gtgaagcggc gactgcaaag agaactgtta 8940 caacttccgt gccatcgtta ttaaatttta attttaaaaa aattgaatta ctacttcaag 9000 acccggttgt aacaattccc ttgcagggca gatacagggt tccgaacgcc aagaccgttg 9060 tttcaaaata cttactctgg ttgtggccac catctgcccg aagcactgca tcttgaagca 9120 actgtggtgt tgaaaacgtt ggccagtagt cgagagaaca ttccactact gctcggtagg 9180 tttgccatac ctgaaaacta cgaattttga tgaaaaatca gaaatttgag cgaaaaaaaa 9240 aaaaatagat gaagtaaagt tgacgcacaa ttgcgtactt ctcgtcagtc ggtgtttgca 9300 cagcttacat tttgaattac gacaattgtt attgcagctt ttctcgacag aaaaatcgtt 9360 ttgattgtta aacgttacaa ttgtatcatt tcctctgatg gtttcattgt tttgaaaaat 9420 taaattattg cagtggctct cgtccagatc atgcacaagt atgtacgttc cgaatagaca 9480 atttggtggc ggcaatccgg aaagtcatag acgccgtgat caggtattcg agtttttctt 9540 gaagttttga gtcaaaaatt ttaaaaagaa tgtttgacac aaaatatatt aaattttact 9600 tatataattt caatgatcaa aaagaatttt aacgcttcaa tgctaccctt ctcccaaagc 9660 tataattttt aataaacgag cattgcgaaa tgaaataaac tagtcaagtc ttctgacaac 9720 tcgtttctat tcataacaac acaccttcta ttggtgtctt tcgaactctt ttacaaagaa 9780 ggaccctcct gcaagtttta ttatgtctgc gtctcgcatt gcacttgatc cgtcactaat 9840 gactagaaaa ggtgtcctag acaacctaag agaaatagta tttaaaaaaa gatgcgctga 9900 gacaaaaaag agcgaacgta tgcctgtaat ggctccaatt ttatcgatta taaattgatg 9960 ctagccaatt ttcgtaaatt agttttctcg gtcaaatctg atctcaccaa aataagtgat 10020 tgttaccgaa taatttgata agatcctact acgtgattcc attttgttct tctaaattag 10080 cagcgattaa gaatgtttta cttcgaaaaa aactactttc cggtgcacat ttcttcaatt 10140 tccattttct ttttatcgaa aattgaacgg aatgtttaaa aaactggaaa ataaatgtat 10200 aaataaaaat ttaaaatgtt tgacacagtt aaagcacgaa ccataaaata taaaaaactt 10260 gagcaaacaa aagtatattt tttctttctt tttgcatctt tcgaacaatg tttacttttg 10320 caatatgtgc tcgtttctct ttttattttc attttaatcg tgggttatgc tttcagcaaa 10380 agtacaatta tatccattaa cagttcatac ctgtccatct tttccgaaga ttcgcttctc 10440 attttagcgc cctgtgctta tcagcggcgg gtcggggcgc ctttgcttct cttcaacttt 10500 cactatcaaa atgtcagaaa cacatctgtt ctttgcgtaa cccatcatca tcatcatcat 10560 agtctttttt tcagaaacaa gcatccttgg tgctccgaac catgacaaca atcgcacagt 10620 ctgttttttg ttttcttgcc ggattcttca acttttttct cctatatttc cgcaaaacga 10680 gcagagcggt aagctatttt attccaatta ttctaaagta aaccgaattt ccagtactgc 10740 aaatatcaag ttgtcaagta tcacagcaac attccaatgt ctcctcttac aacacataga 10800 ctatgtaagt tcgaattttt tattcaaatg taccgaatat aactgtaaaa tgttatagaa 10860 tttttcgaag tggttaaaaa tgtatttttt attgcacaga aaaagaaagt agaaaatgcc 10920 gaactttgct taaaaatcga taaattaacc tgaaaataaa tttatttgcg gaagaatgcc 10980 tgaaaattaa aaaaaaaggc aaaacgtgga tgaaaaaatt atatagctgg aaaacctcaa 11040 aaataaaatt atcgtttgtt caaaaatcaa aatatgaaaa aaaaataaaa cagttagaaa 11100 atatcaacag tttttggcag ttatattcgg tatttatagt gaatctttga agagctgtaa 11160 acttataacg aaattgtttt tcagtgactg tgaaacggaa aatcctggtt ttggatcttg 11220 acgaaacact cattcattca catcatgacg gtgttcttcg acaaacagtc aaacctggaa 11280 ctccgtctga ttttacgata cgggtattcg tttttaacaa gaaatgtttc cacttaaacc 11340 tcaattacag gtggttatcg atcgacatcc tgtgaaattc tcggttcacg aacgtccaca 11400 tgtcgactat tttttgtcag ttgtcagtca atggtagttt attaaatatt ataacaaaaa 11460 tatatggtaa ctgttttagg tatgaattgg tggttttcac agcgagtatg gaagtttatg 11520 gaacatcagt agctgatcgg ttagatcgtg gacgaggaat tctcaagagg cggttagtag 11580 tttttatatt tccccgatgc ttgattgcgc aatttttaaa aagttgtaca ccttcaaaga 11640 gtactgtaat ttcgaaattg ttgttgatta ttgttttttt tttgaaaaac aagttaagaa 11700 acattcaaat atcaattaaa tatccgtaac aacaattttt gaaagttata gttatcttta 11760 aaggcgcgca cattcttgta ttgggcaaaa attgtcgatg aaacatcgca aaatatgggt 11820 tatttaaaaa aagttcatcg tgaatttttt aaaaatttta tattgaatta gagcttcaca 11880 ttttggattc tttctctgaa gacggaacac tgattaaaaa ttttcagtta tttccgtcaa 11940 cattgcacaa tggaagtcgg aggctatacg aaggatttgt ctgcaattca tcccgatctt 12000 tcaagcatct gtattcttga caactctcct ggagcctatc gaaaattccc acgtaagtgt 12060 tttaagagtt tacgatttct agagctttct ggagttttta gaagggatct gaagaaatat 12120 cctgatcttt gttctgaaga tcaaaaatat tgctgatttt caaattagaa gttttcagac 12180 aatgccattc caattccatc atggttttct gatccaaacg acacgtgtct tctcaatctt 12240 cttccattcc tcgacgcact tcgatttacg tcagatgttc gaagtgtgct ctcacggaac 12300 atgcaagctc ttcctgaaac acaatcagta cagtactact aaataggaaa cgagaaagtg 12360 tactgtagta ttctcctcat atctcaattt gcttcaaaaa acccccgtct ctttttgtcc 12420 cagtcgcccc catccaacat ctatctaatt ttagctgtcc tcttcgaggt ggcaaaacat 12480 tatctaaaag tactgcaacg ggttctacac cttctccgtc tcttttcccc ttgaaaaatg 12540 tgtgcgtttt ttattgattt ctgcaaagta tttattgata ccgaagattg tgtgcgtcta 12600 ggcgtccaga atagaacttt taactccatt tcagctcatt ttatttttta gaatcattaa 12660 atatctctag attcgtattt cttctcctga ctctttttct gcacattttt cttccgtttt 12720 caatcataac atgcagtttt atttatagat tcataattaa attgataagt gctgcaatct 12780 aactgtattt ctttttgttc ctctccacat cagtcttttt tcgccagatg gccacgatcg 12840 tttcttatat tatattacat atataaaata atttattgat atcatcatca tcatcactat 12900 tatcattatc atcaccatct catcccccac ctatttataa taagaaacca aaataacaac 12960 attaggaaca tttttattaa tttattaaga cgatcatcag tattcgaagt cttccatcat 13020 gtttcttttg tgtgttccag cgaatctcag catgcggcat ctaaaataat tgactgattt 13080 ttcggaaaat ctaatttgaa aaaaaaaact aacttttctg ggtaaaagat gcaccatgac 13140 tcgacggacg gtgccagcgc acgagattct ctattgacaa gaggcgatgg aaatgcggac 13200 gatgttgaga tgtaaatggt taggagcaag ataagagcac ggatgacgta catatttgtg 13260 gacggctgaa aatgtttaaa tcaagaagct tttcctttca gcatcaaatt taaaaaataa 13320 aattatcagg aaaatcaaca ctttcaaggg aaaatatagg aatctgtgga ttttatactc 13380 tatgaaatac atttaaagca tccaagttcc tattttgagt gcaaaaatga cgagatttct 13440 aatctattaa catagaaacc aaatataaaa agaaaatttc ttcccgggaa actcatagaa 13500 attgctaaat aagtgtgagt ggtaaataaa gaacaaagga tatgatattt gggaagaaac 13560 cgatttttct gagaagacaa caatgtggga aaaagaaatg agtaagttca ggaaaaagta 13620 tgtagtgcaa caaggaaata gtcatagatc tcgtgggaag ttctaatgtg ggagtcaaat 13680 tgatacttgt aggcaaggtt acggtagcag gcaatttggt gattgtttcg ttgaccaact 13740 atatattaaa tatcaattaa ccagtaaaaa aaaagagaaa tatgatgtta acataaagac 13800 cctgacaggg atccaaataa gaatcatgat tttagatttt cgttagtgcg aaaaacgcca 13860 aaaagttcaa agtttgtgct agagcaatga gggaacaatg ataaaataaa ttataaaaat 13920 aaattcaata ctttaaaagg aatattgaga aaaatcataa cttaacttat cagaaaactt 13980 agttaacttt gaagaaatca gtctcaattc atttcaatta gtatcgcaaa aaaaagttat 14040 atgaaaacat attatatatt tctacttttt ctcagtttaa ttacattgaa aaaataaata 14100 agatccgctt tggccacatt tacaaaattt aaattttaac tgagtgacca agtagaagaa 14160 caaatagata gattttatac agaaaaaatg ccaaaaatac catttgcaat tttttgaaca 14220 gtttctctaa aataactcaa aacttccata taaaatgtag tttttcgtat atctcactat 14280 attccactga gacttcattc ataatttaca tcctcaacgg ttctcagaca aatgattaaa 14340 aacaaggtat tgaaagtgaa ggtggtgacc tgaatactga ataaaagatc agttgtatga 14400 ttctgcagtg tgctcttgaa ataaaaactt taaatctaat tccaaaattg tgcattaatt 14460 atgacaactt gaaaatctgg gaaaacgata taatattgca gctttcattt ttgttttcgt 14520 tacgttttct agccgtaata tgatcaaata aaattattct acgttttctc tagaagatca 14580 gaactcacag tcattgagtt attttttaag atctatagaa agttgtttct cgtaactatt 14640 atatgtgtga ttgaagtcag acactggaac gatgtcctac tttttgaata gaaaaagtca 14700 tatggtgtgg gttggtagac aattttaaac ttcaactgta a 14741 // |
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