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EBI DbfetchID U20781; SV 1; linear; genomic DNA; STD; INV; 1849 BP. XX AC U20781; XX DT 08-MAY-1995 (Rel. 43, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Trypanosoma brucei dihydrofolate reductase-thymidylate synthase gene, DE complete cds. XX KW . XX OS Trypanosoma brucei OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma. XX RN [1] RP 1-1849 RX DOI; 10.1016/0166-6851(95)00059-A RX PUBMED; 8538681. RA Gamarro F., Yu P.L., Zhao J., Edman U., Greene P.J., Santi D.; RT "Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene RT isolation and expression and characterization of the enzyme"; RL Mol. Biochem. Parasitol. 72(1-2):11-22(1995). XX RN [2] RP 1-1849 RA Greene P.J.; RT ; RL Submitted (07-FEB-1995) to the EMBL/GenBank/DDBJ databases. RL Patricia J. Greene, Pharmaceutical Chemistry, University of California at RL San Francisco, San Francisco, CA 94143-0446, USA XX FH Key Location/Qualifiers FH FT source 1..1849 FT /organism="Trypanosoma brucei" FT /strain="427" FT /mol_type="genomic DNA" FT /clone="pTBTS7" FT /db_xref="taxon:5691" FT CDS 170..1753 FT /codon_start=1 FT /product="dihydrofolate reductase-thymidylate synthase" FT /db_xref="GOA:Q27783" FT /db_xref="HSSP:1CI7" FT /db_xref="InterPro:IPR017925" FT /db_xref="UniProtKB/Swiss-Prot:Q27783" FT /protein_id="AAA91362.1" FT /translation="MLSLTRILRKKIPVHELAGKISRPPLRPFSVVVASDEKGGIGDGG FT TIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVV FT LSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGG FT TIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTPEGLELVRESITDERV FT STGAGGKKYQFEKLVPRNSEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLR FT NNRLPLLTTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDY FT DEMDLGPVYGFQWRHFGADYISCKVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPA FT ALPRMALPPCHMMAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLR FT PGELVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSP FT YPVISMEMAV" XX SQ Sequence 1849 BP; 454 A; 409 C; 514 G; 472 T; 0 other; aaaaataggc ttaatcgaaa tttacataga aatacttgcg tttgttcacg tgtgtgcttg 60 tgtgaagtgg taaaaacatc atttgccata cacacgtggg aagaggtaaa cttcatttgc 120 tcgttagggc atcccttacg cttcagcaac tgcaatacca aagggggtca tgctcagtct 180 tacgcgtatc ctccgcaaga aaattcctgt tcatgagttg gcggggaaaa tttcccgccc 240 tcccctgcga cccttctctg ttgttgtagc gtcggacgag aagggtggga ttggggacgg 300 tggtacgatc ccctgggaaa tacctgagga catgcaatac ttcagaaggg taacgacaaa 360 ccttcggggg aaaaatgtaa agccatcgcc aagtaaacgg aatgctgttg tgatggggcg 420 gaaaacatgg gacagtcttc caccaaagtt ccgtccactg tctaaccgcc ttaatgttgt 480 gctgtcacga agtgcgacaa aggaacagtt gttggctggt atccctgatc ccatcaaacg 540 agcggaggct gcgaatgatg tggttgctgt gaacggtggg cttgaagacg cacttcggat 600 gttggtaagt aaggagcaca catcttctat cgaaacggtg ttttgcattg gtggcgggac 660 tatatataaa caagcccttt gtgccccatg cgttaatgtg ttgcaagcta tccaccggac 720 ggtggtccga ccagcctcaa attcgtgtag cgttttcttt gacatcccag ccgcagggac 780 aaagaccccg gaaggacttg agttggtgcg ggaaagcata acggacgaac gggtatcaac 840 cggagctggc ggaaagaaat atcagtttga gaagcttgtc ccccgaaaca gcgaagagga 900 gcagtattta aatctcgttg gccgcataat tgatgaggga tgtacgaaat gtgaccgcac 960 gggtgttggt acccgctccc tctttggggc ccagatgcgt ttctctctcc gcaacaatcg 1020 cctgccgtta ctaaccacga agcgtgtctt ttggcgtgga gtatgtgaag agctgttgtg 1080 gtttcttcgg ggagaaacaa atgcaaagtt gctgagcgac aaggggattc acatatggga 1140 tgggaatggc tcacgagcat tccttgacag tcgtggcttg actgattatg atgagatgga 1200 cctcggacct gtttatggct tccagtggag gcattttggt gccgactaca tttcttgcaa 1260 agtggattcc gaggggaagg gtgttgatca gattgcaaac attgtgaagt cattgataga 1320 gaatccggat gaccgtcgca tgatttgtac agcttggaat ccggccgcct tgccacgcat 1380 ggcgctccca ccatgccaca tgatggcgca attctacgtg agcaatgggg aactctcatg 1440 catgttgtac cagcggtcat gtgatatggg tcttggcgtc cccttcaata ttgcttcgta 1500 tgcactgctt acattcctca tggcaaaagc ttctggactt cggccgggcg aattggtgca 1560 cacccttggc gatgcacatg tttacagtaa ccatgtggag ccgtgtcgga agcaattgaa 1620 acgcgtgccc cgccccttcc ctttcatcgt gttcaaacaa gacaaagagt tcctggaaga 1680 ctttcaggaa agcgatatag aggtcatcga ttattctccg taccccgtaa tttctatgga 1740 gatggcggtg taggaatggg tggaaatgct gagaatgatt ctgcgaacac gggcgcgata 1800 ttgtttatgg aagcaattgt tgaagatgtt gttttacgct gccgggttg 1849 // |
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