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EBI DbfetchID M95053; SV 1; linear; genomic DNA; STD; PRO; 4908 BP. XX AC M95053; M64289; M96562; XX DT 29-OCT-1992 (Rel. 33, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 8) XX DE Neisseria meningitidis SiaA (siaA), CMP-NeuNAc synthetase (siaB), siaC DE (siaC), and siaD (siaD) genes, complete cds. XX KW siaA; siaB; siaC; siaD. XX OS Neisseria meningitidis OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; OC Neisseria. XX RN [1] RP 2861-4641 RX DOI; 10.1111/j.1365-2958.1991.tb01899.x RX PUBMED; 1659649. RA Frosch M., Edwards U., Bousset K., Krausse B., Weisgerber C.; RT "Evidence for a common molecular origin of the capsule gene loci in RT gram-negative bacteria expressing group II capsular polysaccharides"; RL Mol. Microbiol. 5(5):1251-1263(1991). XX RN [2] RP 1210-1987 RX DOI; 10.1016/0378-1097(92)90397-7 RX PUBMED; 1398032. RA Edwards U., Frosch M.; RT "Sequence and functional analysis of the cloned Neisseria meningitidis RT CMP-NeuNAc synthetase"; RL FEMS Microbiol. Lett. 75(2-3):161-166(1992). XX RN [3] RP 1-4908 RA Edwards U., Muller A., Hammerschmidt S., Frosch M.; RT "Molecular analysis of the biosynthesis pathway of the alpha 2,8 polysialic RT acid capsule by Neisseria meningitidis serogroup B"; RL Unpublished. XX RN [4] RP 1210-1987 RA Frosch M.; RT ; RL Submitted (28-OCT-1992) to the EMBL/GenBank/DDBJ databases. RL Matthias Frosch, Medizinische Hochschule Hannover, Institut fur RL Medizinische Mikrobiologie, Konstanty Gutschow Strasse 8, Hannover, RL Germany, 30623 XX RN [5] RP 1-4908 RA Frosch M.; RT ; RL Submitted (25-MAY-1994) to the EMBL/GenBank/DDBJ databases. RL Matthias Frosch, Medizinische Hochschule Hannover, Institut fur RL Medizinische Mikrobiologie, Konstanty Gutschow Strasse 8, Hannover, RL Germany, 30623 XX CC On Apr 4, 2002 this sequence version replaced gi:150354 gi:497288. XX FH Key Location/Qualifiers FH FT source 1..4908 FT /organism="Neisseria meningitidis" FT /host="Homo sapiens" FT /isolate="B1940" FT /mol_type="genomic DNA" FT /db_xref="taxon:487" FT -10_signal 51..56 FT /standard_name="-10 signal" FT CDS 174..1307 FT /codon_start=1 FT /transl_table=11 FT /gene="siaA" FT /product="SiaA" FT /db_xref="GOA:Q79DN7" FT /db_xref="InterPro:IPR003331" FT /db_xref="InterPro:IPR020004" FT /db_xref="UniProtKB/TrEMBL:Q79DN7" FT /protein_id="AAA20475.1" FT /translation="MKRILCITGTRADFGKLKPLLAYIENHPDLELHLIVTGMHMMKTY FT GRTYKEVTRENYQHTYLFSNQIQGEPMGAVLGNTITFISRLSDEIEPDMVMIHGDRLEA FT LAGAAVGALSSRLVCHIEGGELSGTVDDSIRHSISKLSHIHLVANEQAVTRLVQMGEKR FT KHIHIIGSPDLDVMASSTLPSLEEVKEYYGLPYENYGISMFHPVTTEAHLMPQYAAQYF FT KALELSGQNIISIYPNNDTGTESILQELLKYQSDKFIAFPSIRFEYFLVLLKHAKFMVG FT NSSAGIREAPLYGVPSIDVGTRQNNRHMGKSIIHTDYETKNIFDAIQQACSLGKFEADD FT TFNGGDTRTSTERFAEVINNPETWNVSAQKRFIDLNL" FT CDS 1311..1997 FT /codon_start=1 FT /transl_table=11 FT /gene="siaB" FT /product="CMP-NeuNAc synthetase" FT /db_xref="GOA:P0A0Z7" FT /db_xref="InterPro:IPR003329" FT /db_xref="UniProtKB/Swiss-Prot:P0A0Z7" FT /citation=[2] FT /protein_id="AAA20476.1" FT /translation="MEKQNIAVILARQNSKGLPLKNLRKMNGISLLGHTINAAISSKCF FT DRIIVSTDGGLIAEEAKNFGVEVVLRPAELASDTASSISGVIHALETIGSNSGTVTLLQ FT PTSPLRTGAHIREAFSLFDEKIKGSVVSACPMEHHPLKTLLQINNGEYAPMRHLSDLEQ FT PRQQLPQAFRPNGAIYINDTASLIANNCFFIAPTKLYIMSHQDSIDIDTELDLQQAENI FT LNHKES" FT CDS 1998..3047 FT /codon_start=1 FT /transl_table=11 FT /gene="siaC" FT /product="siaC" FT /db_xref="GOA:Q57265" FT /db_xref="InterPro:IPR006190" FT /db_xref="InterPro:IPR013132" FT /db_xref="InterPro:IPR013785" FT /db_xref="InterPro:IPR013974" FT /db_xref="InterPro:IPR020007" FT /db_xref="PDB:1XUU" FT /db_xref="PDB:1XUZ" FT /db_xref="PDB:2ZDR" FT /db_xref="PDB:3CM4" FT /db_xref="UniProtKB/TrEMBL:Q57265" FT /citation=[1] FT /protein_id="AAA20477.1" FT /translation="MQNNNEFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAY FT NAGAEVVKHQTHIVEDEMSDEAKQVIPGNADVSIYEIMERCALNEEDEIKLKEYVESKG FT MIFISTPFSRAAALRLQRMDIPAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSIESI FT KKSVEIIREAGVPYALLHCTNIYPTPYEDVRLGGMNDLSEAFPDAIIGLSDHTLDNYAC FT LGAVALGGSILERHFTDRMDRPGPDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAG FT EKPTKDFAFASVVADKDIKKGELLSGDNLWVKRPGNGDFSVNEYETLFGKVAACNIRKG FT AQIKKTDIE" FT CDS 3131..4618 FT /codon_start=1 FT /transl_table=11 FT /gene="siaD" FT /db_xref="InterPro:IPR010866" FT /db_xref="UniProtKB/TrEMBL:Q51281" FT /citation=[3] FT /protein_id="AAA20478.1" FT /translation="MLKKIKKALFQPKKFFQDSMWLTTSPFYLTPPRNNLFVISNLGQL FT NQVQSLIKIQKLTNNLLVILYTSKNLKMPKLVHQSANKNLFESIYLFELPRSPNNITPK FT KLLYIYRSYKKILNIIQPAHLYMLSFTGHYSYLISIAKKKNITTHLIDEGTGTYAPLLE FT SFSYHPTKLERYLIGNNLNIKGYIDHFDILHVPFPEYAKKIFNAKKYNRFFAHAGGISI FT NNNIANLQKKYQISKNDYIFVSQRYPISDDLYYKSIVEILNSISLQIKGKIFIKLHPKE FT MGNNYVMSLFLNMVEINPRLVVINEPPFLIEPLIYLTNPKGIIGLASSSLIYTPLLSPS FT TQCLSIGELIINLIQKYSMVENTEMIQEHLEIIKKFNFINILNDLNGVISNPLFKTEET FT FETLLKSAEFAYKSKNYFQAIFYWQLASKNNITLLGHKALWYYNALYNVKQIYKMEYSD FT IFYIDNISVDFHSKDKLTWEKIKHYYYSADNRIGRDR" XX SQ Sequence 4908 BP; 1680 A; 919 C; 812 G; 1497 T; 0 other; ataatactgc tgacgaatat aaaatttcac tttaaacaca agccaaatcc taatataatt 60 ataaatggcc taattatagc acttaatcga aataaattta tgagtacgta gagtataatt 120 agtattcttc tttccaactt ccttatactt atatacttat agattctaaa atcatgaaaa 180 gaattctttg cattacaggt accagagccg acttcggcaa gctaaaacct ttattagcct 240 atattgaaaa tcacccagac cttgaattgc atttgattgt aactggtatg catatgatga 300 aaacatatgg cagaacctac aaggaagtaa ctcgagaaaa ctatcaacat acatatctgt 360 tttcaaatca aatccaaggt gaaccaatgg gtgccgtttt aggcaatacc attacgttta 420 tctctcgtct atctgatgaa attgaacctg atatggtcat gattcacggc gaccgtttag 480 aagcactagc aggcgcagct gtaggtgcat taagcagccg tttagtttgc catatcgaag 540 gtggtgaact atctggtaca gtagatgact ccattcgtca ttctattagt aaactttctc 600 atatccactt ggtagcaaat gaacaagctg tcactcgcct agtgcaaatg ggagaaaaaa 660 gaaagcatat tcacatcatc ggctcccccg atttagatgt tatggcctct tccaccctcc 720 catccttaga agaagtcaaa gaatattacg gtttaccata cgaaaattat ggtatttcta 780 tgtttcaccc cgtgactaca gaagcacatt taatgccaca atatgcggcc caatatttca 840 aagcattaga attaagtggc caaaatatca ttagcatcta ccctaataat gacactggca 900 ctgaaagtat tctgcaagaa ttattaaaat atcaatctga taaatttatt gcatttcctt 960 ccattcgatt tgaatatttt ttagtcttat tgaaacatgc taaatttatg gtcggcaact 1020 caagtgcagg tattagagaa gctcctctct acggtgtccc ttcaattgat gttggtacac 1080 gccaaaataa ccgccatatg ggaaaatcta ttattcatac agattatgaa actaaaaata 1140 tctttgatgc gattcaacaa gcatgcagtt taggcaaatt tgaagcagat gataccttta 1200 atggcggaga tactcgcacc agcacagaaa gatttgctga agtaatcaac aatcctgaaa 1260 cgtggaatgt ttctgctcaa aaacgtttta tcgatttgaa tctttaaatt atggaaaaac 1320 aaaatattgc ggttatactt gcgcgccaaa actccaaagg attgccatta aaaaatctcc 1380 ggaaaatgaa tggcatatca ttacttggtc atacaattaa tgctgctata tcatcaaagt 1440 gttttgaccg cataattgtt tcgactgatg gcgggttaat tgcagaagaa gctaaaaatt 1500 tcggtgtcga agtcgtccta cgccctgcag agctggcctc cgatacagcc agctctattt 1560 caggtgtaat acatgcttta gaaacaattg gcagtaattc cggcacagta accctattac 1620 aaccaaccag tccattacgc acaggggctc atattcgtga agctttttct ctatttgatg 1680 agaaaataaa aggatccgtt gtctctgcat gcccaatgga gcatcatcca ctaaaaaccc 1740 tgcttcaaat caataatggc gaatatgccc ccatgcgcca tctaagcgat ttggagcagc 1800 ctcgccaaca attacctcaa gcatttaggc ctaatggtgc aatttacatt aatgatactg 1860 cttcactaat tgcaaataat tgttttttta tcgccccaac caaactttat attatgtctc 1920 atcaagactc tatcgatatt gatactgagc ttgatttaca acaggcagaa aacattctta 1980 atcacaagga aagctaaatg caaaacaaca acgaatttaa aattggtaat cgttcagtag 2040 gttacaacca cgaaccattg attatctgtg aaatcggcat caatcatgaa ggctctttaa 2100 aaacagcttt tgaaatggtt gatgctgcct ataatgcagg cgctgaagtt gttaaacatc 2160 aaacacacat cgttgaagac gaaatgtctg atgaggccaa acaagtcatt ccaggcaatg 2220 cagatgtctc tatttatgaa attatggaac gttgcgccct gaatgaagaa gatgagatta 2280 aattaaaaga atacgtagag agtaagggta tgatttttat cagtactcct ttctctcgtg 2340 cagctgcttt acgattacaa cgtatggata ttccagcata taaaatcggc tctggcgaat 2400 gtaataacta cccattaatt aaactggtgg cctcttttgg taagcctatt attctctcta 2460 ccggcatgaa ttctattgaa agcatcaaaa agtcggtaga aattattcga gaagcagggg 2520 taccttatgc tttgcttcac tgtaccaaca tctacccaac cccttacgaa gatgttcgat 2580 tgggtggtat gaacgattta tctgaagcct ttccagacgc aatcattggc ctgtctgacc 2640 ataccttaga taactatgct tgcttaggag cagtagcttt aggcggttcg attttagagc 2700 gtcactttac tgaccgcatg gatcgcccag gtccggatat tgtatgctct atgaatccgg 2760 atacttttaa agagctcaag caaggcgctc atgctttaaa attggcacgc ggcggcaaaa 2820 aagacacgat tatcgcggga gaaaagccaa ctaaagattt cgcctttgca tctgtcgtag 2880 cagataaaga cattaaaaaa ggagaactgt tgtccggaga taacctatgg gttaaacgcc 2940 caggcaatgg agacttcagc gtcaacgaat atgaaacatt atttggtaag gtcgctgctt 3000 gcaatattcg caaaggtgct caaatcaaaa aaactgatat tgaataatgc ttattaactt 3060 agttacttta ttaacagagg attggctatt acatatagct aattctcatt aatttttaag 3120 agatacaata atgctaaaga aaataaaaaa agctcttttt cagcctaaaa agttttttca 3180 agattcaatg tggttgacaa catctccatt ttatcttacc cccccacgta acaatttatt 3240 tgtcatatct aatttaggtc agcttaacca agtccaaagc ctaattaaaa tacaaaaatt 3300 aaccaataat ttactagtaa ttttatatac ttctaaaaac ttaaaaatgc ctaagttagt 3360 tcatcaatca gctaacaaga atctatttga atctatttat ctatttgagc ttcctagaag 3420 ccctaataat ataactccta aaaaattact ttatatttat agaagttaca aaaaaatcct 3480 taatattata cagcctgctc atctctatat gctgtctttt acaggccact actcctatct 3540 gattagtatt gcaaaaaaaa agaatattac gactcattta attgatgaag ggactggaac 3600 atatgctcct ttattagaat cattttcata tcatccaaca aaattagaac gttatttgat 3660 tggaaataat cttaatatta aaggatatat agatcatttt gacatattgc atgtcccctt 3720 tcctgaatat gctaaaaaaa tatttaatgc aaaaaaatat aaccggtttt ttgcgcatgc 3780 tggaggaata agcattaata ataacattgc aaacttacag aaaaaatatc aaatatctaa 3840 aaatgactat atttttgtta gtcaacgcta ccccatttca gatgatttgt attataagag 3900 tatagtagaa atcttaaaca gcataagttt acaaattaaa ggaaagatat ttattaaact 3960 acacccaaaa gagatgggca acaactatgt aatgtcttta tttctaaata tggtagaaat 4020 aaaccctcgg ctggtagtta ttaatgaacc tccttttcta attgagcccc taatatactt 4080 aacaaatcct aaaggaatta taggcctggc ctctagttct ttaatttata caccattact 4140 ctcaccctca acccaatgtc tttctattgg agagttaatt attaacttaa ttcaaaaata 4200 ttcaatggtg gaaaacactg aaatgatcca agaacactta gagattatta agaaatttaa 4260 ttttattaat atactaaatg atttaaatgg ggtaataagt aaccctctct ttaaaacaga 4320 agaaacattt gaaacacttc ttaaatctgc agaattcgca tataaatcta aaaactactt 4380 tcaggctatt ttttactggc aacttgccag caaaaacaat attaccttat tagggcataa 4440 agcattatgg tactacaatg cactttataa tgtaaaacaa atttataaga tggaatattc 4500 agatattttt tatatcgata atatctccgt agactttcat agtaaagata aattgacatg 4560 ggaaaaaatt aaacattatt actattccgc cgacaataga attggtagag atagataaaa 4620 atactatgac ttctgatctc catacgtatg cttgttttca aaaagcagca ttaagataga 4680 taagtgaagc ttgatgagag ccatttttgt ggtcatcgcc aaggtacacg cggagagtaa 4740 tcgacaacag agctgctgta ttctggcttt taaagcccag tagtaaagtt tataaggctg 4800 catttctcaa tgtaaaacgc gatattttca cccattatta gggataagta gccagtggtt 4860 tacactggct actttcatag ttatgaagta ctgggtctga gtgaattc 4908 // |
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