 |
|
EBI DbfetchID M65060; SV 1; linear; genomic DNA; STD; PRO; 7306 BP. XX AC M65060; XX DT 27-AUG-1991 (Rel. 29, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 8) XX DE M.thermoautotrophicum trpE, trpG, trpC, trpF, trpB, trpA, trpD genes, DE complete cds. XX KW anthranilate synthase alpha subunit; anthranilate synthase beta subunit; KW indoleglycerolphosphate synthase; phosphoribosylanthranilate isomerase; KW phosphoribosyltransferase; tryptophan synthase alpha subunit; KW tryptophan synthase beta-subunit. XX OS Methanothermobacter thermautotrophicus OC Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; OC Methanobacteriaceae; Methanothermobacter. XX RN [1] RP 1-7306 RX PUBMED; 1860817. RA Meile L., Stettler R., Kotik M., Leisinger T.; RT "Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: RT molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon"; RL J. Bacteriol. 173(16):5017-5023(1991). XX DR RFAM; RF00005; tRNA. XX FH Key Location/Qualifiers FH FT source 1..7306 FT /organism="Methanothermobacter thermautotrophicus" FT /strain="Marburg" FT /mol_type="genomic DNA" FT /db_xref="taxon:145262" FT gene 448..1836 FT /gene="trpE" FT CDS 448..1836 FT /codon_start=1 FT /transl_table=11 FT /gene="trpE" FT /product="anthranilate synthase alpha-subunit" FT /EC_number="4.1.3.27" FT /db_xref="GOA:P26940" FT /db_xref="HSSP:1K0G" FT /db_xref="InterPro:IPR015890" FT /db_xref="UniProtKB/Swiss-Prot:P26940" FT /protein_id="AAA73028.1" FT /translation="MGVNVFKIINLEKPRKEKLEFREPFEVFKSIYSEYESSFLLESME FT SDTGLARYSFIGFEPEMIIRAREGVIEIDDGDSREEFDSKNPFEDLRGFLKMEKNSGGF FT CGGLVGYISYQAARFFDTIRLSEGDFPDFEFGLFLDGIMFNHLTGECSYISRHGNRLPD FT ISPLLGDEVPTGTLGYRRERTLLSKRRYMDMVLEAKERIREGEIFQAVLSSATDYRLRG FT DRLAFYESLRRINPSPYMYHLKLGEREITGSSPEMLVRVEDRRIETFPIAGTRPRGRTE FT EEDGVIASDLLSDEKEQLAEHLMLVDLARNDIGRVSEFGSVEVPEYMTIKRFSHVQHIL FT SHVTGKLRDGMDAVDALGAVFPAGTVSGAPKIRAMEIIESLEGVPRNAYAGALGYLSLN FT GNADFAITIRSMVCQGKTGRIQAGAGIVHDSIPEMEYLECQNKARALLKSMEMAGEQVD FT PYNR" FT gene 1808..2398 FT /gene="trpG" FT CDS 1808..2398 FT /codon_start=1 FT /transl_table=11 FT /gene="trpG" FT /product="anthranilate synthase beta-subunit" FT /EC_number="4.1.3.27" FT /db_xref="GOA:P26923" FT /db_xref="HSSP:1QDL" FT /db_xref="InterPro:IPR006221" FT /db_xref="UniProtKB/Swiss-Prot:P26923" FT /protein_id="AAA73029.1" FT /translation="MNKLILIIDNYDSFTHNLYQMAGEIMMEMDSADIMVVRNDEVDID FT YVRGLDPERIIISPGPGNPIKREDFGICSEVIGEFTDRPILGVCLGHQGIFHYFGGVVG FT YGEPVHGKISEVFHDGSELFRGVPNPFRATRYHSLRCECSGVPEDILVSASAPDGTIMA FT IRHRQYPVYGLQFHPESAGTPHGRDILENFLRM" FT gene 2403..3227 FT /gene="trpC" FT CDS 2403..3227 FT /codon_start=1 FT /transl_table=11 FT /gene="trpC" FT /product="indoleglycerolphosphate synthase" FT /EC_number="4.1.1.48" FT /db_xref="GOA:P26939" FT /db_xref="HSSP:1J5T" FT /db_xref="InterPro:IPR001468" FT /db_xref="UniProtKB/Swiss-Prot:P26939" FT /protein_id="AAA73030.1" FT /translation="MSILQEIIRSRKLEIKNLSRKKPLEELRDELTSLDEPLSFTDALT FT GNRVSLICEYKRASPSSGRTYGRGLHEMMEVYREGADAVSVITENRYFHGSIEFLREAS FT EYGIPLLMKDFVVDEYQIYQARASGASSVLIITGVFPDLESGIETCRELSMEPLVECHS FT AIDIYRAIEAGAELIGVNNRNLETLEVDLERTRALAPLVPDELLLVSESGVMGPEDAEI FT LAGCGADALLIGTSLMLASDPRELLDEIMAAVKSCKPGRKRYSGDEFFEQFA" FT gene 3255..3935 FT /gene="trpF" FT CDS 3255..3935 FT /codon_start=1 FT /transl_table=11 FT /gene="trpF" FT /product="phosphoribosylanthranilate isomerase" FT /db_xref="GOA:P26941" FT /db_xref="HSSP:1NSJ" FT /db_xref="InterPro:IPR001240" FT /db_xref="UniProtKB/Swiss-Prot:P26941" FT /protein_id="AAA73031.1" FT /translation="MKIKICGLTREEDVVLADSLGADLLGFIHARRSPRHLELGDVAEL FT SSLIPDEKAVLVTETSETSRIMEAIDKTGIERIQLHSVSPETAGKIHESLHAEGYSLEL FT TLAVPPLSSHICGHEFQGISGLILDSASGGRTGGTGKIIPPSDALELLALIRGMDPSLR FT VTLAGGLTLEFVRKNREYVSKFDCLDFNSGIETGPGVKDHEMMAELMNYIEGLPTRKGA FT IEEI" FT gene 3951..5123 FT /gene="trpB" FT CDS 3951..5123 FT /codon_start=1 FT /transl_table=11 FT /gene="trpB" FT /product="tryptophan synthase beta-subunit" FT /EC_number="4.2.1.20" FT /db_xref="GOA:P26921" FT /db_xref="HSSP:1K7F" FT /db_xref="InterPro:IPR006654" FT /db_xref="UniProtKB/Swiss-Prot:P26921" FT /protein_id="AAA73032.1" FT /translation="MDGKFGKYGGIFVPELLIPALEELEAAFLHYSKDRRFNEDLEHYL FT REYAGRPTGLYHARNLSEKLGCRVYLKREDMLHTGAHKINNTIGQALLAGYMGKRRLIA FT ETGAGQHGIATAAAGALFGMDVDVYMGTEDVERQKLNVFRMEISGARVIPVDSGSRTLK FT DAINQAMRDWISSVEDTHYLIGSTMGPHPYPTMVKHFQSVIGREAREQILEIEGELPDT FT IIACVGGGSNAIGIFSAFLDDDVELIGAEGGGEGIESGNHGATLSAGSEGVLHGSLSYV FT LQDDDGQINEAHSVSAGLDYPGVGPEHAYLMETGRAMYEPITDAEALRGFKLLSRCEGI FT MPALESAHAIACLEKYASKPENRGKTVIVNLSGRGDKDMFLAAGLLGVDL" FT gene 5179..5976 FT /gene="trpA" FT CDS 5179..5976 FT /codon_start=1 FT /transl_table=11 FT /gene="trpA" FT /product="tryptophan synthase alpha-subunit" FT /EC_number="4.2.1.20" FT /db_xref="GOA:P26920" FT /db_xref="HSSP:2WSY" FT /db_xref="InterPro:IPR002028" FT /db_xref="UniProtKB/Swiss-Prot:P26920" FT /protein_id="AAA73033.1" FT /translation="MNYAEMFSRVEGCAFVPFVVAGDPDMETSVEIIRTLVDAGADALE FT IGFPFSDPIADGTSVQEADLRALNSGMTTDDCFRLIERIREFTSVPVGLLVYYNLIYRM FT GADEFYRRAAEAGVTGILAADLPPEEAGDALRAAERYGIDQIFIVAPTTDNQRLKMISE FT VSSGFHYLVSVMGVTGARSRVEESTLELIERVKGAGSLPVMVGFGVSQPEHVRMLADAG FT ADGVIVGSAIIDLISKNLDDRERMLQEIYEMVRKMKTAAGGSR" FT gene 5973..7025 FT /gene="trpD" FT CDS 5973..7025 FT /codon_start=1 FT /transl_table=11 FT /gene="trpD" FT /product="anthranilate phosphoribosyltransferase" FT /EC_number="2.4.2.18" FT /db_xref="GOA:P26925" FT /db_xref="HSSP:1KHD" FT /db_xref="InterPro:IPR020072" FT /db_xref="UniProtKB/Swiss-Prot:P26925" FT /protein_id="AAA73034.1" FT /translation="MRFEGIMNDIMDFRNLSEDEAHDLMEMIMDGEMGDVQIAALLTAL FT AMKGETVDEITGFARAMRERAVKVKIPESMRVVDACGTGGDRFKSYNVSTAAAIIAAAA FT GVKVAKHGNRAVTGSCGGADILEAAGVNIELGPEAACRSLETLGIAFMFAPLFHRATAR FT VAPVRRELGFKTVFNILGPLTSPASAEVQLLGVFDPYLVGPVAEVLRNLGVKRAMVVHG FT FDGNMNPAMDEISTVGPTLVGFLEDDEIGIKRLMPPDFGVDVGQLQHLKAASTVDGNLR FT MFMDVLAGLDDTPGRKSRLDIALANAGALIYLAEMEDTLEGGTEAARETVESGAALRLM FT EDFASFTQNL" XX SQ Sequence 7306 BP; 1986 A; 1627 C; 2028 G; 1665 T; 0 other; gatatcagct ctgcagcggc agcaagtatc ccgggattac gggcctccgc ctctatctcc 60 acaacaccaa agtcaagttc ggctgcagcg tccctcagga gtgcccctgc tggtctgagg 120 ttctggaata tccccctgag tttttcgtcc tccaggatgg tttctgccgt tgccctgact 180 gttctcctgt caacgcctat ggcccttgca agggcaacgt catttatttc aacgtcatca 240 cagtagacct ttccatcagg gtctattctg agtcccagct ctatgatctt ccttgcaaca 300 tccattctcg aagggtatct ttcgaatctg tgctttatct gattccacat aaccacacca 360 catcaatgta cattattata caggcaagat ttaaatagta ctttcatgta taagtacttt 420 gtggattaat taaggtgatg ggaatgcatg ggagtgaatg tttttaaaat tataaacctg 480 gaaaaaccca gaaaagaaaa actggaattc cgagaaccct ttgaagtatt caaaagtatc 540 tattctgaat atgagtcttc attccttctt gagtccatgg aaagtgacac tggacttgca 600 aggtactcct tcattggatt tgaacctgag atgataataa gggcccgtga aggggtcatt 660 gagattgatg atggcgattc cagggaggag tttgattcaa aaaacccatt cgaggacctc 720 aggggattcc tgaagatgga aaaaaactcc ggaggattct gcgggggact cgtgggttac 780 atatcctatc aggccgcaag gttctttgac acaatcaggc tcagtgaagg tgatttcccc 840 gacttcgaat ttggactctt ccttgatggt atcatgttca accacctgac aggggaatgc 900 agctacatca gccgccacgg caacagacta cctgatatat cccctctcct tggggatgag 960 gtccccacag ggaccctggg atacaggagg gaaagaacac tcctctcaaa gaggaggtac 1020 atggacatgg tccttgaggc caaggagaga ataagggagg gtgaaatatt tcaggcagtg 1080 ctctccagtg ccacagatta caggctgagg ggagacaggc tcgcattcta tgaatccctc 1140 aggaggataa acccctcacc atacatgtac caccttaaac tgggtgaacg ggagataacc 1200 ggctcaagcc ccgagatgct tgtcagggtt gaagatagaa ggattgaaac atttcccatt 1260 gcaggaacac gccctcgtgg aaggacagaa gaggaggacg gggtgatagc atctgatctt 1320 ttatctgatg aaaaggaaca acttgcagag cacctcatgc tggttgacct ggcccggaac 1380 gatatagggc gggtatcgga gttcggatcg gtggaggtac ctgaatacat gaccataaag 1440 aggttctccc atgtgcagca catactctcc catgtaacag gtaaactgag ggatggaatg 1500 gacgcagttg atgcactggg agctgttttt cctgcaggca cagtgagcgg cgcaccaaag 1560 ataagggcaa tggagataat agagtccctt gaaggtgttc caagaaatgc ctatgcaggc 1620 gcactaggct acctctcact caatggaaac gcggacttcg caataaccat aaggtcaatg 1680 gtatgccagg ggaaaacagg gagaatccag gcgggagcag gaatagtgca tgactccatc 1740 cctgagatgg aatatctgga gtgccagaat aaggcgaggg cccttctaaa atcaatggag 1800 atggcaggtg aacaagttga tccttataat cgataactat gactcattca cccataacct 1860 ctaccagatg gcaggggaga tcatgatgga aatggattct gcagatataa tggttgtgag 1920 aaacgatgag gtggacattg attatgttag gggccttgat cctgaaagga taataatctc 1980 cccgggtcca ggcaacccca ttaagaggga agatttcggc atatgcagtg aggtgatagg 2040 tgaattcact gataggccca tactgggagt ctgcctcggg caccagggga tattccatta 2100 ctttgggggg gtggttggtt acggtgaacc tgttcatgga aagatcagcg aggtcttcca 2160 cgacggatca gaactcttca ggggagttcc aaatcccttc agggccacaa ggtaccattc 2220 actgagatgt gaatgcagtg gggtgcctga ggacatcctg gtatctgcat ctgcacctga 2280 cggcaccata atggccataa gacaccggca gtatccagtc tacgggttac agtttcaccc 2340 ggagtcagcg ggaacccccc atgggaggga catacttgaa aatttcctca ggatgtgatc 2400 acatgtccat actccaggag ataataaggt caagaaaact tgagatcaaa aatttatcca 2460 gaaaaaagcc ccttgaggag ctcagggatg aattaacatc cctggacgaa ccattgagtt 2520 tcactgatgc cctcacagga aacagggtat cactcatatg cgaatataaa agggcatccc 2580 cctcatcagg aagaacctat gggagaggcc tccatgagat gatggaggtg tacagggagg 2640 gagcagacgc tgtttctgtt atcacagaga acaggtactt ccatggctcc atcgagttcc 2700 tcagggaggc ttcagaatat gggatacccc tcctcatgaa ggacttcgtg gtggacgagt 2760 accagatata ccaggcaagg gcatcagggg catcatcggt cctcatcata acaggggttt 2820 tccctgacct tgaatcagga attgaaacct gcagggaact ctcaatggag cccctggtgg 2880 agtgtcacag tgcaatcgac atatacaggg ccatagaggc cggggcagag ctcataggag 2940 ttaacaacag aaacctggaa acacttgagg ttgaccttga gcgcacaagg gcactggccc 3000 ccctggtacc ggatgagctg cttctggtat ccgaaagcgg ggtcatggga cctgaggatg 3060 ctgagatcct tgcaggctgc ggggcagacg cactactcat aggaacctcc ctcatgctgg 3120 ccagtgatcc acgggaactc cttgatgaga taatggcagc tgttaaatca tgcaaacctg 3180 gcagaaagag gtattcaggg gatgaattct ttgaacagtt cgcatgagca atctcgggga 3240 tagggatgat tcagatgaag atcaagatct gtgggctcac aagggaggag gatgtggtcc 3300 ttgcagattc acttggggca gatttactgg gattcataca tgcacgcagg tcaccaaggc 3360 accttgaact gggggatgtg gcggagctct cctccctcat accagatgaa aaggcggttc 3420 ttgtcactga gacatcagaa accagcagga taatggaggc catagataaa acaggtatag 3480 aaaggataca gcttcactct gtaagtcctg aaacagcggg aaaaatccat gagtccctcc 3540 atgcggaggg atacagtctg gagctgaccc tcgccgtccc ccctctttct tcccacatct 3600 gcgggcatga atttcaggga atatcaggtc tgatccttga ctcggcttca ggcggaagaa 3660 cagggggcac agggaaaata atacccccct cagatgccct tgagttactg gcccttataa 3720 ggggaatgga tccctccctg agggttacac ttgcaggggg ccttacactg gaatttgtca 3780 ggaaaaacag ggaatatgta tcgaaattcg actgcctgga cttcaactca gggattgaga 3840 ctgggccggg tgtaaaggac catgagatga tggctgaact catgaattac attgagggac 3900 tccccaccag aaaaggggca attgaagaaa tataggtgtt tatcatgata atggatggta 3960 aattcggtaa atatggggga atattcgtgc cagaactcct catacctgca cttgaggagc 4020 ttgaggcggc attcctccac tacagtaagg ataggaggtt caatgaggac ctggaacact 4080 acctgaggga atacgcagga agaccaacag gtttgtacca cgccaggaac ctctcagaga 4140 aacttggatg cagggtctac ctcaagaggg aggatatgct gcatacaggg gcccataaaa 4200 taaacaatac aataggccag gcactccttg cagggtatat gggtaagagg aggctgatag 4260 cagagacagg ggcagggcag catggaatag caactgcagc agcaggcgcc ctctttggga 4320 tggatgttga tgtctacatg ggaaccgagg atgttgagag acagaaacta aacgtcttca 4380 ggatggaaat ttcaggtgca agggtcatac ctgttgattc aggttcaagg acacttaagg 4440 acgccataaa ccaggccatg agggactgga taagcagcgt ggaggacacc cactatctga 4500 taggatccac catggggccc cacccatacc ccaccatggt gaagcacttc cagagcgtca 4560 taggaaggga ggccagagaa cagatacttg aaattgaggg tgaacttcct gacaccataa 4620 tagcctgtgt tggtggcggt agcaacgcca taggtatatt ctcagccttc ctggacgatg 4680 atgttgaact gataggtgca gagggagggg gtgaaggtat agagtcagga aaccatgggg 4740 caaccctatc ggctggttca gagggtgtac tgcacggttc actttcatat gtactccagg 4800 atgacgatgg acagataaat gaggcccatt cggtttcggc gggccttgac tatcccgggg 4860 ttggcccgga gcacgcatac ctcatggaga ccggaagggc aatgtatgag cccataaccg 4920 acgccgaggc cctcaggggc ttcaaactcc tctcaagatg tgagggtata atgccggcgc 4980 ttgaaagcgc ccatgccata gcatgccttg aaaaatacgc ctcaaaacct gaaaacaggg 5040 gaaagactgt catagttaac ctttcaggaa ggggagacaa ggacatgttc cttgcagcag 5100 gccttctggg ggtggatcta tgaattacgc cagagtaact cagaacgatg tatgcagggc 5160 tggtctggag gtggatctat gaattacgct gaaatgttca gcagggttga gggatgcgcc 5220 tttgttccat ttgtggttgc aggggatcct gacatggaga cctcagttga aatcataaga 5280 acacttgtgg atgccggtgc agatgccctt gaaataggtt tcccattctc tgaccccata 5340 gcagacggca caagtgtaca ggaggctgat ctgagggctt taaattccgg gatgaccacc 5400 gatgactgtt tcaggttgat agagagaata agggaattca cctcagtacc ggtgggtctt 5460 ctcgtatact acaacctgat ataccgcatg ggtgctgatg aattctacag gagggccgcc 5520 gaggccggtg ttacaggtat ccttgccgcg gaccttcccc cggaggaggc cggcgatgcc 5580 ctcagggcgg ctgaaagata tggaattgat cagatattca tagttgcacc cacaacagac 5640 aatcagcgcc tcaaaatgat ctcagaggtt tcatcagggt tccactacct tgtatcggtt 5700 atgggtgtca ccggtgcaag gtccagggtt gaggagagca cacttgaact catagagagg 5760 gttaaggggg caggaagcct tcctgtgatg gtcggctttg gtgtttcaca gccagaacat 5820 gtgagaatgc ttgctgacgc aggtgccgat ggtgttatag ttggaagtgc aatcatagac 5880 ctgatatcca aaaatcttga tgacagggaa aggatgcttc aggagatata cgaaatggtc 5940 agaaaaatga agaccgctgc aggggggtcc agatgaggtt tgaggggata atgaatgata 6000 taatggactt caggaacctc agtgaggatg aggcccacga tttaatggag atgataatgg 6060 atggtgaaat gggggatgtg cagatcgccg cattactcac agcccttgca atgaaggggg 6120 agaccgtgga tgagatcaca gggtttgcaa gggcaatgag ggagagggca gtgaaggtta 6180 aaatccctga atccatgagg gtcgttgatg catgtggaac agggggtgac aggttcaaat 6240 catacaatgt gagcaccgca gcagcaataa tagccgccgc agccggtgtt aaggttgcaa 6300 aacacggcaa cagggcggtt acaggttcat gcggcggtgc agatatactt gaggccgcgg 6360 gtgtcaacat agagctggga cctgaagctg catgcaggtc tcttgaaact ctgggaatag 6420 ccttcatgtt tgcaccactc tttcacaggg caaccgccag ggtggcaccc gtaaggaggg 6480 aacttggctt taagacggta ttcaacatac tggggcccct aacatcccct gcatcagcag 6540 aggtacagct cctgggggta tttgatccct accttgttgg tccagttgca gaggtcctca 6600 gaaaccttgg tgttaaaagg gctatggttg tccatggctt tgatggtaac atgaaccctg 6660 cgatggatga gatatccacg gtgggcccaa cacttgtggg tttccttgag gatgatgaga 6720 tagggattaa gaggctcatg ccaccggatt tcggtgttga tgttgggcag ctacagcacc 6780 tgaaggcggc atcaactgtt gatggaaacc tcagaatgtt catggatgtc ctcgctggac 6840 ttgatgatac tcctgggagg aaatcgcgcc tggatatcgc ccttgcaaat gcaggtgcac 6900 tgatatacct tgctgaaatg gaggatacac ttgaaggtgg aacagaagct gcaagagaaa 6960 cagttgaatc tggagctgca ctccgtttaa tggaagattt cgcatccttc actcagaacc 7020 tgtaaaagtg aatgggcccg ctgggattcg aacccagggc ctcacggtta tcagccgtgc 7080 gctctaacca cctgagccac gggcccatga agcatttaag aatcagtggg gtgattccaa 7140 cttttggaat tcatcatata tatgcttttc tgtccgggaa tccagcagtt ttttcagcat 7200 caaccccgta aaatcccgag gtcctctgct gctttgatga tctcagtgat ttcagatgcg 7260 gtcctttcag gggtcctgtt ttcaaccaca cactgacaat ggatcc 7306 // |
|