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EBI DbfetchID M59757; SV 2; linear; genomic DNA; STD; PRO; 12611 BP. XX AC M59757; XX DT 09-JUL-1991 (Rel. 28, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 8) XX DE Bacillus subtilis ORF1A (pyrR), putative membrane-bound uracil permease DE (pyrP), aspartate transcarbamylase (pyrB), dihydroorotase (pyrC), DE glutaminase of carbamyl phosphate synthetase (pyrAA), carbamyl phosphate DE synthetase (pyrAB), dihydroorotase dehydrogenase (pyrD), OMP decarboxylase DE (pyrF), and OMP-PRPP transferase (pyrE) genes, complete cds; and unknown DE gene. XX KW . XX OS Bacillus subtilis OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. XX RN [1] RP 1-12611 RX PUBMED; 1709162. RA Quinn C.L., Stephenson B.T., Switzer R.L.; RT "Functional organization and nucleotide sequence of the Bacillus subtilis RT pyrimidine biosynthetic operon"; RL J. Biol. Chem. 266(14):9113-9127(1991). XX RN [2] RP 1173-1534 RX PUBMED; 8206849. RA Turner R.J., Lu Y., Switzer R.L.; RT "Regulation of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene RT cluster by an autogenous transcriptional attenuation mechanism"; RL J. Bacteriol. 176(12):3708-3722(1994). XX RN [3] RP 1-12611 RA Switzer R.; RT ; RL Submitted (26-APR-1993) to the EMBL/GenBank/DDBJ databases. RL Department of Biochemistry, 318 Roger Adams Laboratory, University of RL Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA XX RN [4] RC Sequence update by submitter RP 1-12611 RA Switzer R.; RT ; RL Submitted (26-MAY-1999) to the EMBL/GenBank/DDBJ databases. RL Department of Biochemistry, 318 Roger Adams Laboratory, University of RL Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA XX DR GOA; Q45480. DR InterPro; IPR002942; S4_RNA_bd. DR RFAM; RF00515; PyrR. DR UniProtKB/Swiss-Prot; Q45480; YLYB_BACSU. XX CC On May 26, 1999 this sequence version replaced gi:387576. XX FH Key Location/Qualifiers FH FT source 1..12611 FT /organism="Bacillus subtilis" FT /strain="JH861 and 1A610" FT /mol_type="genomic DNA" FT /db_xref="taxon:1423" FT -35_signal 504..509 FT -10_signal 527..532 FT mRNA 543 FT /note="transcription start site" FT CDS 690..1235 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrR" FT /note="ORF1A" FT /db_xref="GOA:P39765" FT /db_xref="InterPro:IPR002375" FT /db_xref="PDB:1A3C" FT /db_xref="UniProtKB/Swiss-Prot:P39765" FT /protein_id="AAA21265.2" FT /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIY FT LAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVILV FT DDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVM FT VQLDEVDQNDLVAIYENE" FT CDS 1409..2713 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrP" FT /product="putative membrane-bound uracil permease" FT /note="ORF1B" FT /db_xref="GOA:P39766" FT /db_xref="InterPro:IPR006042" FT /db_xref="UniProtKB/Swiss-Prot:P39766" FT /protein_id="AAA21266.1" FT /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMSP FT AVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGLVY FT GLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYSLKH FT FSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWFAVPE FT FIIPFKDYHRQLRSASQPQWFLSHLSQCQSISATNGAESKVVGQDFIKAGLHRSIMGDS FT VATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKISALISSVP FT SAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAFIQVSQGGF FT QVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI" FT CDS 2859..3773 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrB" FT /product="aspartate transcarbamylase" FT /db_xref="GOA:P05654" FT /db_xref="InterPro:IPR002082" FT /db_xref="PDB:2AT2" FT /db_xref="UniProtKB/Swiss-Prot:P05654" FT /protein_id="AAA21267.1" FT /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFFE FT PSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSEDE FT YYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSRVAR FT SNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQSAVS FT QEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKNGVFIR FT MAVIQCALQTNVKRGEAAYVISH" FT CDS 3757..5043 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrC" FT /product="dihydroorotase" FT /db_xref="GOA:P25995" FT /db_xref="InterPro:IPR002195" FT /db_xref="UniProtKB/Swiss-Prot:P25995" FT /protein_id="AAA21268.1" FT /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVID FT AKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAGRGGYTTVAAMPNTRPVPDTKEQM FT EWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGMMYE FT AMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLLGA FT NCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRS FT PEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFRNCRLRNSIPASLHTLCQK FT WQLVTEAADLTYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNT FT PFNGISCTGWPVATIAAGKLAYEEGRLVK" FT CDS 5040..6134 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrAA" FT /product="glutaminase of carbamyl phosphate synthetase" FT /db_xref="GOA:P25993" FT /db_xref="HSSP:1A9X" FT /db_xref="InterPro:IPR000991" FT /db_xref="UniProtKB/Swiss-Prot:P25993" FT /protein_id="AAA21269.1" FT /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDPS FT YCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKMKN FT IPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAKTAY FT PSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSNGPGD FT PKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKELATGK FT VALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASPGPEDAN FT HLFDRFIEMIETTEKEGEAVCQNA" FT CDS 6119..9334 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrAB" FT /product="carbamyl phosphate synthetase" FT /db_xref="GOA:P25994" FT /db_xref="HSSP:1CS0" FT /db_xref="InterPro:IPR013817" FT /db_xref="UniProtKB/Swiss-Prot:P25994" FT /protein_id="AAA21270.1" FT /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEVI FT LVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVELSE FT RGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVSQIG FT FPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEYEVMR FT DSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALGIEGGC FT NVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEMMNPVTG FT KTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEESLLKAVRS FT LEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHEFSAIDVFF FT LHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYSLRKQAGIAP FT VFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQGVEFDYATVH FT SVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDLEQPMGVVVQFG FT GQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQPLGKTATSVNQAV FT SIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQHPVLIDRYLTGKEI FT EVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKKKIEQYTIALAKGLN FT IVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLATKIILGQKLAAFGYT FT EGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKDSTLEKALYKALIASGI FT QIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAGYLKEASIPAKVVGKIGQ FT DGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVENGVACLTSLDTAEAILRVL FT ESMTFRADQMPAVNTNQEAAVTI" FT CDS 9331..10101 FT /codon_start=1 FT /transl_table=11 FT /product="unknown" FT /note="ORF2" FT /db_xref="GOA:P25983" FT /db_xref="HSSP:1EP3" FT /db_xref="InterPro:IPR001433" FT /db_xref="UniProtKB/Swiss-Prot:P25983" FT /protein_id="AAA21271.1" FT /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSEA FT VTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVNEV FT QPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDTYVA FT TADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERMGCGI FT GACFACVCHTNESETSYVKVCLDGPVFKAQEVAL" FT CDS 10101..11036 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrD" FT /product="dihydroorotase dehydrogenase" FT /db_xref="GOA:P25996" FT /db_xref="HSSP:1EP2" FT /db_xref="InterPro:IPR001295" FT /db_xref="UniProtKB/Swiss-Prot:P25996" FT /protein_id="AAA21272.1" FT /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKAT FT TKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQVD FT DYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPVYVK FT LSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAVKPVA FT IRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEIIEQLP FT SVLLQYGYQSIEECIGRSWNHEKQPAHHRA" FT CDS 11005..11724 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrF" FT /product="OMP decarboxylase" FT /db_xref="GOA:P25971" FT /db_xref="InterPro:IPR001754" FT /db_xref="PDB:1DBT" FT /db_xref="UniProtKB/Swiss-Prot:P25971" FT /protein_id="AAA21273.1" FT /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGPS FT IVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEGLE FT EGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVVCSV FT HEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSITKAED FT PVKAYKAVRLEWEGIKS" FT CDS 11703..12353 FT /codon_start=1 FT /transl_table=11 FT /gene="pyrE" FT /product="OMP-PRPP transferase" FT /db_xref="GOA:P25972" FT /db_xref="InterPro:IPR000836" FT /db_xref="UniProtKB/Swiss-Prot:P25972" FT /protein_id="AAA21274.1" FT /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNRL FT TLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSKPK FT AHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGLPKA FT EEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK" FT terminator 12374..12425 XX SQ Sequence 12611 BP; 3748 A; 2660 C; 3183 G; 3020 T; 0 other; atcgataagg acacgtccgg tttattaatg gtggcgaaaa atgatatggc gcacgagtca 60 ctcgtaaacc aattggtcaa caaaacggtc acgcggaaat atacggcggt tgtccacggg 120 cttatttctc atgatgacgg cacaattgac gcgccgatcg gacgggataa aaaagaccgt 180 caaagcatga ctgtgacacg tgatggcaaa aacgctgtca ctcattttca tgtgcttgag 240 ggttttcagg attttacgtt agtggagtgc cagcttgaaa cagggagaac ccatcaaatt 300 cgtgttcata tgaaatatat cggattccca ttagcaggcg atccgaaata cggcccaaga 360 aaaacaatcg actttaatgg ccaaccgctt cacgcggcga gttttaggtt ttgaccatcc 420 acgaacagga gaatatgtcg aattttgaag cgtcgcgttc ccgaggatat ggcagaatta 480 atcgaaaacc tcagaaaaaa cggttgacag agggtttctt ttctgaaata ataaacgaag 540 ctgaatagat tctttaaaac agtccagaga ggctgagaag gataacggat agacgggatg 600 cgtgtatagg cgcgcacctt gtcctaaaac ccctctatgc tctggcagga ggggtttttt 660 cttctatatg aactgtgagg tgtcacacat tgaatcaaaa agctgtcatt ctcgacgaac 720 aggcaattag acgggcgctg accaggattg ctcacgaaat gatcgaacgc aataaaggaa 780 tgaataactg cattcttgtc ggcattaaga caagagggat ttacctggca aaacgccttg 840 cggaacgcat tgaacagatt gagggaaatc ctgttacagt cggtgaaatt gatattactc 900 tttacagaga tgatctttct aaaaaaacaa gcaacgatga accgcttgta aaaggtgcag 960 atattccggt agatattaca gatcaaaaag tcattctcgt tgatgatgtt ctgtataccg 1020 gaagaacagt cagagcagga atggatgcgc ttgttgatgt aggcagacct tcctccattc 1080 agcttgcagt gcttgtggac agaggacacc gggagctgcc gatccgagcg gattatatcg 1140 ggaaaaacat cccgacatca aagtctgaaa aggttatggt acagcttgat gaggtagacc 1200 aaaacgatct cgtcgccatt tatgaaaacg aataatagat caccttttta agggcaatcc 1260 agagaggttg caaagaggtg cacaacaaag gcccaaaaag tattcggcag gtctttgtat 1320 gcctctttgc gtaaaaaagc aaagaggttt ttttatacag tcattgagtc atcctaaaat 1380 gaaagtcaac aatcaggggg aaatcatcat gagtaagaaa aaagtaaatt taggggtcag 1440 ggatgtcccg acacctttct cttgggtttc attcagcctt cagcatttgt ttgccatgtt 1500 tggctcaacc attttggttc cgaagctcgt cggaatgagt cctgctgtgg cgttggtgac 1560 aagcggcatc ggaacactgg cgtaccttct tattaccaaa ggacaaattc cggcgtatct 1620 cggttcatcc ttcgccttta tttctccgat cattctggta aaagcgaccg gcgggccggg 1680 agcggcaatg gttggagcgt ttcttgcagg gctggtgtac gggctgattg ccttattgat 1740 taggcagctt ggaacaggat ggctgatgaa gattctcccg cctgtagtcg tagggcctgt 1800 tattatcgtc atcgggctgg gactggcaag cactgcagta aacatggcga tgtatgctga 1860 tccgaacgcg agtgagttgg tctacagctt aaagcacttt agtgtcgcag gagttacgct 1920 ggcaattacg attatttgtg cgattttctt acgagggttt ttaagcctga ttccggttct 1980 gatcggaatc atcggcggat acctgtttgc ccttactcaa gggattgtca acttccagcc 2040 ggtgcttgac gcgaaatggt ttgcagtgcc tgaatttatc attccgttca aagattatca 2100 ccgtcagtta cgctcggcat cgcagccgca atggttcctg tcgcatttgt cacaatgtca 2160 gagcatatcg gccaccaatg gtgctgagag caaggttgtc ggacaagact tcataaaagc 2220 aggtcttcat cgctctatta tgggtgacag tgtggcgaca atcctcgctt ccctgatcgg 2280 cggccctccg acaacgactt acggagaaaa cattggcgtg ctggccatca caagagtatt 2340 cagcgtcttt gtcatcgggg gcgcggcagt gattgccctt tgcttcggct ttatcggcaa 2400 aatttcagcg ctgatcagtt cagtgccgtc agcggtcatg ggaggcgtct ccttcctgct 2460 gttcggaatc attgcttcaa gcggcctgag aatgctgatt gacaacaaaa ttgattatga 2520 aaacaacaga aacctcatta ttacatcagt tatccttgtc atcggtgtag gaggcgcttt 2580 tatccaagtg tctcagggcg gattccaagt gtcaggaatg gcgcttgccg caattgtcgg 2640 tgtcatctta aacctgattc ttccgcaggc gaaggaagag caggcagaca catctgaaca 2700 acatcatatt taaaaccttt taatgaaagt ccagagaggc ttggaagggt tatgaagaga 2760 aggaagcttc aatgctgccc tctatttaac cataccccga gtctatctta gaccggggtt 2820 ttttttcagc cttaagttga aaagagaggg gaaagaacat gaagcattta acgacgatga 2880 gtgaacttag cactgaggaa atcaaagatt tgcttcaaac agcacaagag ctcaaaagcg 2940 gaaaaacaga caatcagctt acaggaaagt ttgcagcaaa cctgtttttc gaaccgagca 3000 cgagaacgcg gttcagcttt gaggtcgcag aaaaaaagct gggcatgaat gtgcttaacc 3060 ttgatggaac aagcacaagc gtgcaaaaag gcgaaacctt atatgacacg atccggacgc 3120 ttgaatcaat cggtgtggac gtctgcgtca tcaggcacag tgaggatgag tattatgaag 3180 agcttgtcag ccaggtgaac attccgattc tgaatgcggg agacgggtgc ggccagcatc 3240 caacacaatc actgcttgat ttaatgacga tttatgaaga gttcaatacg tttaaagggc 3300 ttaccgtctc cattcacggc gacatcaagc atagcagagt ggcaaggtca aatgcggaag 3360 tgttgacaag attgggtgcc cgggtcctat tttccggccc ttcggaatgg caggatgaag 3420 aaaatacatt cggcacgtat gtctcaatgg atgaagcagt tgagtcttcc gatgttgtca 3480 tgctgctgcg cattcaaaat gaacgacatc agtccgctgt cagtcaggaa ggctatttaa 3540 acaaatacgg cttgaccgta gaacgggctg agcgtatgaa gcggcatgcg atcatcatgc 3600 atcctgctcc ggtaaacaga ggagtggaga ttgatgacag cttagtagaa agcgaaaaat 3660 caagaatctt caagcaaatg aaaaatggcg tatttatcag aatggcagtg atacagtgtg 3720 ccttacaaac caatgtgaaa agaggagaag cagcgtatgt catatctcat taaaaacggc 3780 tggatactaa acgaaaatgg tgaaaaaaca caagcggata tccgagtgac tggagaaacc 3840 atcaccgcaa tcggcaagct tgatgcaacg gataatgaaa cggtaattga tgcaaaaggt 3900 ttgctcgttt cacctgggtt tgttgatctc cacgtgcatt tcagagagcc gggcggagag 3960 aaaaaagaaa ctattgaaac cggggcaaaa gcagccggcc gcggcggcta tactacagta 4020 gcagcaatgc cgaatacgcg gccggttcct gatacaaagg agcagatgga atgggtgcaa 4080 aacagaatta aagaaacatc atgcgtaaga gttcttccat atgcatccat tacgatcaga 4140 caaatcggcg atgaaatgac aaactttgaa gcgttaaaag aagccggggc atttgctttt 4200 acagatgacg gcgttggtat acagacagca ggaatgatgt atgaagcgat gaaacgggca 4260 gccgcaattg acaaagcgat tgttgcacat tgcgaggaca actccttaat ttacggaggg 4320 agcgtacatg aggggacatt ctccaaagcg aacgggctaa acggcattcc ttctgtgtgt 4380 gaatcggttc atattgctcg cgatgtgctg ctgctaggcg caaactgcca ttatcatgta 4440 tgccatatca gcacaaaaga atctgtcaga gttgtacgcg atgcgaaaaa agcgggaatc 4500 agagtgacag cagaagtatc gccgcatcat ttgctgcttt gtgatgagga catcccgggg 4560 ctggacacaa actataaaat gaatcctccg ctccgcagcc cagaagacag agctgcttta 4620 attgaaggtc ttttagacgg aacaattgat tttatcgcaa cagaccatgc accgcatacg 4680 gaagaagaga agaacacaga aatgaagctg gcgccatttc ggaattgtcg gcttagaaac 4740 agcattcccg cttctttaca cacactttgt caaaaatggc agctggtcac tgaagcagct 4800 gatttgacct acatgacaat caagccatgc gaagcgttcg gtctcccata tggaacatta 4860 caaacggggc aagctgcgga cattacgtta atcgatttag aaaaagaagc agttatagac 4920 aaagagacat ttttatcaaa aggaaaaaat acaccattca acggcatcag ttgcaccggc 4980 tggccggtcg ctacaattgc ggcagggaag cttgcttatg aagaggggag acttgtcaaa 5040 tgaagagacg attagtactg gaaaacggag cggtattcga gggagaagct ttcggaagct 5100 tagaacacaa catgggagaa gtcgttttta atactgggat gacaggctat caggaaattt 5160 tatctgatcc ttcttactgc ggacagatcg taacattaac atacccgctt atcggaaatt 5220 acggcattaa ccgtgatgat tttgaatcca ttaccccttt tgtcaaaggg ctgatcatca 5280 aagaattatg tgagctgcct tccaactggc gttcagcata caccttagac gagtatttaa 5340 aaatgaaaaa cattcccgga ctccagggaa ttgatacaag gaagctgaca agaatgatcc 5400 gcacggcagg cgcgctaaaa ggaacattcg cttcatctga tgaagatatc gaagcagtgc 5460 tgaaaagact gaacgaaacg gaattgccaa gaaatcaagt atcccaagta tcagcaaaaa 5520 cagcatatcc gagcccggga agaggcaaac gcattgtctt ggttgacttc ggcatgaaac 5580 acgggattct aagagagctg aacaaacgga aatgtgacgt catcgttgtg ccttacaaca 5640 ttacagcgga agaggtgctt cagctgaaac cggacggtat catgctttct aacggacctg 5700 gagacccgaa ggatgtgcct gaagcgattg aaatgattaa aggtgttctt ggaaaagtgc 5760 cattattcgg aatatgtctc ggccaccaat tattcgcgct ggcgtgcggg gcgaatactg 5820 aaaaaatgaa attcggccac aggggctcaa accacccggt aaaagagctg gctacaggaa 5880 aagttgcctt aacatctcaa aaccatggat atacagtttc gtctatcagt aaaacagaac 5940 tggaagtgac gcatatcgca attaacgacg atacgattga agggctgaag cataaaacat 6000 tgccggcatt tacggttcaa tatcatcccg aagcctcacc tggtcctgag gatgccaacc 6060 atctatttga cagattcatc gaaatgatcg aaacaacaga gaaagaaggg gaagcggtat 6120 gccaaaacgc gtagacatta acaaaatttt agtaatcgga tctggaccga tcatcatcgg 6180 ccaagcagca gaatttgact atgcgggaac acaagcctgt cttgctttga aagaagaagg 6240 ctatgaagtc atccttgtca actcaaaccc tgcaacgatc atgacagata cagaaatggc 6300 tgaccgggtt tacatcgaac cgctcacacc tgaattcctg acacgaatca tcagaaaaga 6360 gcgcccggat gccattcttc ctacactcgg aggccaaacc ggtttgaatc ttgcggttga 6420 gctttctgaa agaggcgttt tggcagaatg cggcgtcgaa gtgcttggca cgaaactgtc 6480 tgcgattcag caagctgaag accgtgactt gttcagaaca ttaatgaatg aactgaatga 6540 accggtgcct gaaagtgaga ttatccactc ccttgaagaa gcagaaaaat tcgtcagtca 6600 aattggattc cctgtcattg tccgcccggc atatacatta ggcggaacag gcggaggcat 6660 ctgctcgaat gaaacagagc taaaagaaat cgttgagaac ggcttgaaat taagcccggt 6720 acaccaatgt ctgcttgaaa aaagcatcgc cggctataaa gaaatcgagt atgaagtcat 6780 gagagacagc caggatcacg ccattgtcgt ttgtaacatg gaaaacattg atccagttgg 6840 aatccatact ggagacagta ttgttgtcgc gccgagccaa acgctcagcg atcgcgaata 6900 tcagctcttg cggaatgtat cgttaaaact gattcgcgcg cttgggatcg aaggcggatg 6960 taatgtccag ctcgccttag atccagacag cttccaatat tacattattg aagtaaatcc 7020 gcgtgtcagc cgttcatctg cccttgcatc aaaagcaacg gggtacccga ttgcaaagct 7080 cgctgctaaa attgcagtcg gactttcatt agatgaaatg atgaacccgg tgacaggaaa 7140 aacatatgca gcatttgaac ctgctcttga ctatgtcgta tccaaaattc cgcgctggcc 7200 gtttgataag tttgaatcag caaacagaaa gcttggcacg caaatgaaag cgacaggtga 7260 ggtcatggca atcggccgca cgcttgaaga gtcattgctg aaggcagtgc gatcactgga 7320 agcggatgtg tatcatcttg aattgaagga cgccgctgac atttcagatg agcttcttga 7380 aaagcgaatt aaaaaggccg gtgatgaacg cttattctac ttagctgaag cgtacagaag 7440 aggctacacg gtagaagacc tccatgaatt ttccgctatc gatgtcttct tcttgcataa 7500 gctgttcgga atcgtacagt ttgaaaaaga attgaaggcc aatgcgggcg atacagatgt 7560 gctgagacgg gcaaaagaac tcggcttctc tgatcagtac atcagccgtg aatggaaaat 7620 gaaagaatct gagctttaca gcttgagaaa acaagcgggg attgcgccgg tattcaaaat 7680 ggtagataca tgcgcggcgg aatttgagtc agaaacgcca tacttctata gcacatatga 7740 agaagaaaat gaatctgtcg ttacagataa gaaaagtgtg atggtgcttg gttcgggtcc 7800 gattcgaatc ggtcagggtg tcgagttcga ctatgcgacg gttcactctg tatgggcaat 7860 taaacaagca ggctatgaag ccattattgt caacaacaac ccggaaaccg tttcaacaga 7920 cttcagcatc tcagacaagc tgtattttga accgcttacg attgaagatg tcatgcacat 7980 cattgacctc gaacagccaa tgggcgttgt cgtacaattt ggcggacaaa ctgcgattaa 8040 ccttgctgac gagctttctg cacgcggagt gaaaatcctt ggaacttcat tagaagattt 8100 agaccgtgcc gaagaccggg ataaatttga acaagcgctt ggagaacttg gtgttcctca 8160 gccgcttggc aaaacagcga catcagttaa tcaggcggta agcatcgcaa gtgatatcgg 8220 ttatccggta ctggtacgcc cttcctatgt acttggcggc cgggcgatgg agattgttta 8280 ccatgaagag gaactgcttc attacatgaa aaatgcagtc aaaatcaatc cacagcaccc 8340 tgtattaatt gatagatact tgaccggaaa agaaattgaa gtcgatgcag tatccgacgg 8400 tgaaacagtc gtcattccgg gaattatgga gcacattgaa cgtgcgggcg ttcactccgg 8460 agactcaatc gctgtttatc cgcctcagtc tctcacagag gacattaaga aaaaaattga 8520 acaatacacg atcgcattgg ctaaagggct gaatattgtc ggtttgctca atattcaatt 8580 cgtcttgtcg caaggcgagg tgtacgtgct agaagtgaat ccgagatcaa gcagaaccgt 8640 accgttttta agcaaaatta cgggtatccc aatggcgaat ctcgcaacaa aaatcattct 8700 tggtcaaaag ctggctgcgt ttggctatac agagggcctt cagcctgaac agcaaggtgt 8760 atttgtaaaa gcgccggtct tctcctttgc caagctgaga agagtggata ttacgttagg 8820 gcctgaaatg aaatcaacag gtgaagtcat ggggaaagat tcgacacttg aaaaggcgct 8880 ctacaaagcc ttgatcgctt caggtattca aatcccgaac tacggttccg tgcttttaac 8940 agtagctgat aaggacaaag aagaagggct tgccattgct aagcggttcc acgcgatcgg 9000 ctacaacatt ttagcgacgg aaggaacggc aggctacctg aaagaagctt ccattccagc 9060 gaaggtcgtc ggaaaaatcg gtcaggatgg cccgaacttg cttgatgtca tcagaaacgg 9120 agaagcgcag tttgtcatca atacgctgac aaaaggaaag cagccggcaa gagacggttt 9180 tagaatcaga cgtgaatcag tagaaaatgg tgttgcctgc ctaacatctt tagatacggc 9240 agaggcgata ttgcgagtgc tggaaagcat gacattccgt gctgatcaaa tgccggcagt 9300 caacacaaat caggaggcgg cagtcactat atgaaaaaag cgtatttgac agtatgttct 9360 aaccagcaaa ttgcagaccg ggtgtttcaa atggttctga aaggggagct tgtccaaggg 9420 tttacaaccc ctggacagtt ccttcatctt aaagtgagcg aagcggttac gcctcttttg 9480 agaaggccga tcagcatcgc agacgtcaac tttgaaaaaa atgaagtcac catcatttat 9540 cgggtagatg gggaagggac aagactcttg tcactgaagc agcagggaga acttgtggat 9600 gtcctcgggc ctttgggaaa tggctttcct gttaatgaag ttcaacccgg aaagacggct 9660 ttgctggtag gaggcggagt aggtgtgccg cctctccaag agctgtcgaa acgcttgatt 9720 gaaaaagggg taaatgtcat ccacgtttta ggattccaat cggcaaagga tgttttttac 9780 gaggaagaat gccggcagta cggagacacg tatgtggcaa cagctgacgg aagctacggg 9840 gaaaccggat ttgtcacaga tgtgattaaa cggaaaaagc tagagtttga tatcctcctc 9900 agctgcgggc cgacaccgat gctcaaggcg ttaaaacagg aatatgccca taaagaagta 9960 tatctgtcca tggaggaacg aatgggctgc ggaatcggcg catgcttcgc gtgtgtgtgc 10020 catacaaacg aaagtgagac atcctatgta aaagtatgtc tcgacgggcc tgtatttaaa 10080 gctcaggagg tggcgctgta atgctagagg tgaaattgcc gggacttgat ttgaaaaacc 10140 caatcattcc tgcatcaggc tgcttcggtt ttggaaaaga attttcacgt ttttatgatt 10200 tgtcttgtct tggagctatc atgattaagg ctacgacaaa ggagccgcgc tttgggaatc 10260 cgacgccgcg ggtagctgag actggtgctg gaatgctcaa tgcgatcggt ctccaaaatc 10320 cggggctgga tagtgtgttg catcatgagc tgccgtggct tgagcagttt gatacaccga 10380 tcattgccaa tgtcgcaggt tctcaagtcg atgattatgt tgaagtcgca gaacatatca 10440 gcaaagcgcc taatgttcat gctcttgaat tgaatatttc ctgcccgaat gtgaaaacag 10500 gcggaatcgc ttttggcacg aatcctgaaa tggctgccga tttgacaaaa gcggtgaaag 10560 aggtttcgga tgtacccgtt tatgtgaagc tatccccgaa cgtggctaat atcacagaaa 10620 ttgcattagc gatcgaggaa gcgggagcgg acggtcttac gatgatcaac acactaatcg 10680 gcatgagact cgatttaaaa accggcaaac cgatattagc gaataaaaca gggggacttt 10740 cgggccctgc tgtgaagccg gttgccattc gcatggtgta tgaagtcagc cagatggtca 10800 acatcccgat tatcggaatg ggaggcgtgc aaacggctga agatgccctg gaatttcttc 10860 tcgcgggagc aagcgcagtc gctgtcggaa cagcaaactt tgtgaatcct tttgcatgtc 10920 cagagattat tgaacagctc ccatctgttt tgctccaata cggctatcaa tcaattgaag 10980 aatgcatcgg aaggagctgg aatcatgaaa aacaacctgc ccatcatcgc gcttgatttt 11040 gcgtcagctg aagaaacact tgcgttctta gcgccttttc agcaagaacc gttatttgta 11100 aaggttggga tggagctttt ttatcaagaa gggccatcta tcgtgaaaca actaaaagaa 11160 agaaactgcg agctattttt agatctaaag cttcatgaca tcccgactac tgtaaacaaa 11220 gcgatgaagc gccttgccag tcttggagta gacctcgtca atgttcatgc tgccgggggc 11280 aaaaaaatga tgcaggcagc tctcgaaggc ttagaagaag gtacgccggc tggaaaaaaa 11340 cgtccgtcac ttatcgcggt aacccagctg acaagcacat ctgaacaaat catgaaagat 11400 gaactgctga tcgaaaagtc tctgattgat acggttgtgc actacagcaa acaggcggaa 11460 gaaagcggac tggatggagt ggtctgctct gttcatgaag caaaagccat ttaccaagcg 11520 gtgtcgcctt catttctgac tgtcactccg gggatcagaa tgtcagagga cgctgcgaat 11580 gaccaagttc gcgtagcgac gcctgccatt gcaagagaga aaggttcatc agcgattgta 11640 gtaggacgct cgattacaaa agcggaagac ccggtaaaag cctataaggc tgtcagactt 11700 gaatgggagg gaatcaaatc ttgaaacaaa tcatcgcaaa acatctatta gacatccaag 11760 ctgtattttt acgcccgaac gagccgttca catgggcaag cggcatttta tcaccgatct 11820 actgtgacaa ccgccttacg ctatctttcc cagaggtcag aaacgatgtt gcttcaggta 11880 tcagcaagct tgttaaagag cattttcctg aagctgaaat gattgcggga acagcaactg 11940 ccggtattcc tcatgctgct cttgcggcgg accatttgaa tcttccgatg tgttatgtga 12000 ggagcaagcc gaaggcgcac ggaaaaggca atcagattga gggagctgtg caagaagggc 12060 aaaaaacagt cgtcattgaa gacttaattt ccacaggagg cagcgtgctt gaagcttgtg 12120 cagctttaca agcggccggc tgtgaagtgc ttggtgtcgt ctcaatcttt acgtacggac 12180 ttcctaaagc ggaggaagcc ttcgcaaagg cagaactgcc atactactca ttaaccgatt 12240 atgatacgct cacagaggtc gcgcttgaaa acggaaatat tcattcagat gatctaaaaa 12300 agctgcaaac atggaaacga aatcccgagt caaaagattg gtttaaaaaa taaaaaataa 12360 attcaaatga tgtaaagagg cttcaaagcc ttgctgtact tgaaaacagg ctgtgaggcc 12420 tgttttttta ttaatcctat aaaaaaagtc gggttgactt atgttagaat tgtgctaaaa 12480 tttactacaa atctaaaaac ttatcaagag cggctgaggg actggaccta tgaagcccgg 12540 caacctgcat agtttgtaag gtgctacttc cagcaaaatg aattccattt tgaaagataa 12600 gggctgcatg c 12611 // |
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