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EBI DbfetchID M36339; SV 1; linear; genomic DNA; STD; VRL; 15212 BP. XX AC M36339; M24214; M59239; XX DT 14-AUG-1990 (Rel. 25, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 10) XX DE Vaccinia virus polyA polymerase large subunit, ORF1 (E2L), ORF2 (E3), RNA DE polymerase subunit (rpo30) (E4L), ORF3 (E5R), ORF4 (E6R), ORF5, ORF6, DNA DE polymerase, ORF7, and ORF8 genes, complete cds. XX KW DNA polymerase; polyA polymerase large subunit; RNA polymerase. XX OS Vaccinia virus OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; OC Orthopoxvirus. XX RN [1] RX DOI; 10.1073/pnas.83.11.3659 RX PUBMED; 3012524. RA Earl P.L., Jones E.V., Moss B.; RT "Homology between DNA polymerases of poxviruses, herpesviruses, and RT adenoviruses: nucleotide sequence of the vaccinia virus DNA polymerase RT gene"; RL Proc. Natl. Acad. Sci. U.S.A. 83(11):3659-3663(1986). XX RN [2] RX PUBMED; 2911123. RA Traktman P., Kelvin M., Pacheco S.; RT "Molecular genetic analysis of vaccinia virus DNA polymerase mutants"; RL J. Virol. 63(2):841-846(1989). XX RN [3] RX DOI; 10.1016/0092-8674(91)90048-4 RX PUBMED; 1670500. RA Gershon P.D., Ahn B.Y., Garfield M., Moss B.; RT "Poly(A) polymerase and a dissociable polyadenylation stimulatory factor RT encoded by vaccinia virus"; RL Cell 66(6):1269-1278(1991). XX RN [4] RP 1-15212, 2041-8280 RA Gershon P., Jones E.V., Moss B., Ahn B.Y.; RT "Eukaryotic transcriptional elongation factor homolog is an integral RT subunit of the vaccinia virus encoded RNA polymerase"; RL Unpublished. XX CC On Apr 5, 2002 this sequence version replaced gi:341130. CC Sequence kindly submitted by B.Y.Ahn, 10-JUL-1990. CC National Institutes of Health CC NIAID/LVD CC 9000 Rockville Pike CC Bethesda, Maryland 20892. XX FH Key Location/Qualifiers FH FT source 1..15212 FT /organism="Vaccinia virus" FT /strain="WR" FT /mol_type="genomic DNA" FT /db_xref="taxon:10245" FT CDS complement(182..1621) FT /codon_start=1 FT /product="polyA polymerase large subunit" FT /db_xref="GOA:P23371" FT /db_xref="InterPro:IPR004976" FT /db_xref="PDB:2GA9" FT /db_xref="PDB:2GAF" FT /db_xref="PDB:3ER8" FT /db_xref="PDB:3ER9" FT /db_xref="PDB:3ERC" FT /db_xref="UniProtKB/Swiss-Prot:P23371" FT /protein_id="AAB59821.1" FT /translation="MNRNPDQNTFPNITLKIIETYLGRVPSVNEYHMLKLQARNIQKIT FT VFNKDIFVSLVKKNKKRFFSDVDTSASEIKDRILSYFSKQTQTYNIGKLFTIIELQSVL FT VTTYTDILGVLTIKAPNVISSKISYNVTSMEELARDMLNSMNVAVIDKAKVMGRHNVSS FT LVKNVNKLMEEYLRRHNKSCICYGSYSLYLINPNILYGDIDILQTNSRTFLIDLAFLIK FT FITGNNIILSKIPYLRNYMVIKDENDNHIIDSFNIRQDTMNVVPKIFIDNIYIVDPTFQ FT LLNMIKMFSQIDRLEDLSKDPEKFNARMATMLEYVRYTHGIVFDGKRNNMPMKCIIDEN FT NRIVTVTTKDYFSFKKCLVYLDENVLSSDILDLNADTSCDFESVTNSVYLIHDNIMYTY FT FSNTILLSDKGKVHEISARGLCAHILLYQMLTSGEYKQCLSDLLNSMMNRDKIPIYSHT FT ERDKKPGRHGFINIEKDIIVF" FT CDS complement(1618..3831) FT /codon_start=1 FT /gene="E2L" FT /note="ORF1" FT /db_xref="InterPro:IPR007585" FT /db_xref="UniProtKB/Swiss-Prot:P21604" FT /protein_id="AAB59822.1" FT /translation="MISVTDIRRAFLDNECHTITKAFGYLHEDKAIALIKIGFHPTYLP FT KVLYNNVVEFVPEKLYLFKPRTVAPLDLISTITKLKNVDKFASHINYHKNSILITGDKS FT LIVKCMPYMIISDDDIRFIREQFVGTNSIEYILSFINKESIYRMSYQFSENEIVTIINR FT DHFMYEPIYEHQVLDSDFLKTMLDRYGIVPINSGIIDELCPEAIIEILMAVVRPRDAIR FT FLDIVNKNQLTEDSVKNYIINDIRRGKIDYYIPYVEDFLEDRTEDLGIYANIFFEDAID FT ITKLDITKTELEHISKYMNYYTTYIDHIVNIILQNNYIDILASIIDYVQDVLTEELCIR FT IVCESTNPVPVTSLPIHSTLVMVMCIQMKYVDIVEFLDEIDIDTLIEKGADPITEYTFT FT TRWYNKHNDLITLYIKKYGFCPMMMKRLMFEYPLTKEASDHLLKTMDENRGAIMFFPRT FT ICTLPYLLCCNYKLIQKPIPFKEENRNIVYKKNNRVLCFDSLENSAFKSLIKIDSIPGL FT KTYNMKDITYEKSNNIICVRFIPQESIHNEERRIKLQLFDIARLASYGLYYIPSRYLSS FT WTPVVNMIEGREYTNPQKIECLVILDLFSEEFIEYQNLGNAVSNKYELEYTISNYQAAI FT NCLMSTLLIYLVLGSIRSISRTENFVLSILNIFYKGLKINELLSEPVSGVCIELNKIKD FT RASSGDSSFIFLKKNELSKTLSLCEKVCVETILDNNQSFKSSK" FT CDS complement(3958..4530) FT /codon_start=1 FT /gene="E3" FT /note="ORF2" FT /db_xref="GOA:P21605" FT /db_xref="InterPro:IPR000607" FT /db_xref="InterPro:IPR001159" FT /db_xref="InterPro:IPR009179" FT /db_xref="InterPro:IPR011991" FT /db_xref="InterPro:IPR014720" FT /db_xref="UniProtKB/Swiss-Prot:P21605" FT /protein_id="AAB59823.1" FT /translation="MSKIYIDERSNAEIVCEAIKTIGIEGATAAQLTRQLNMEKREVNK FT ALYDLQRSAMVYSSDDIPPRWFMTTEADKPDADAMADVIIDDVSREKSMREDHKSFDDV FT IPAKKIIDWKGANPVTVINEYCQITRRDWSFRIESVGPSNSPTFYACVDIDGRVFDKAD FT GKSKRDAKNNAAKLAVDKLLGYVIIRF" FT CDS complement(4586..5365) FT /codon_start=1 FT /gene="E4L" FT /note="RNA polymerase subunit (rpo30)" FT /db_xref="GOA:P21603" FT /db_xref="InterPro:IPR001222" FT /db_xref="InterPro:IPR009162" FT /db_xref="UniProtKB/Swiss-Prot:P21603" FT /protein_id="AAB59824.1" FT /translation="MENVYISSYSSNEQTSMAVTATDIRELLSQYVDDANLEDLIEWAM FT EKSSKYYIKNIGNTKSNIEETKFESKNNIGIEYSKDSRNKLSYRNKPSIATNLEYKTLC FT DMIKGTSGTEKEFLRYLLFGIKCIKKGVEYNIDKIKDVSYNDYFNVLDEKYNTPCPNCK FT SRNTTPMMIQTRAADEPPLVRHACRDCKQHFKPPKFRAFRNLNVTTQSIHENKEITEIL FT PDNNPSPPESPEPASPIDDGLIRATFDRNDEPPEDDE" FT CDS 5414..6439 FT /codon_start=1 FT /gene="E5R" FT /note="ORF3" FT /db_xref="InterPro:IPR004334" FT /db_xref="InterPro:IPR018379" FT /db_xref="UniProtKB/Swiss-Prot:P21606" FT /protein_id="AAB59825.1" FT /translation="MLILTKVNIYMLIIVLWLYGYNFIISESQCPMINDDSFTLKRKYQ FT IDSAESTIKMDKKRTKFQNRAKMVKEINQTIRAAQTHYETLKLGYIKFKRMIRTTTLED FT IAPSIPNNQKTYKLFSDISAIGKASRNPSKMVYALLLYMFPNLFGDDHRFIRYRMHPMS FT KIKHKIFSPFKLNLIRILVEERFYNNECRSNKWRIIGTQVDKMLIAESDKYTIDARYNL FT KPMYRIKGKSEEDTLFIKQMVEQCVTSQELVEKVLKILFRDLFKSGEYKAYRYDDDVEN FT GFIGLDTLKLNIVHDIVEPCMPVRRPVAKILCKEMVNKYFENPLHIIGKNLQECIDFVS FT E" FT CDS 6576..8279 FT /codon_start=1 FT /gene="E6R" FT /note="ORF4" FT /db_xref="InterPro:IPR006749" FT /db_xref="UniProtKB/Swiss-Prot:P21607" FT /protein_id="AAB59826.1" FT /translation="MDFIRRKYLIYTVENNIDFLKDDTLSKVNNFTLNHVLALKYLVSN FT FPQHVITKDVLANTNFFVFIHMVRCCKVYEAVLRHAFDAPTLYVKALTKNYLSFSNTIQ FT SYKETVHKLTQDEKFLEVAKYMDELGELIGVNYDLVLNPLFHGGEPIKDMEIIFLKLFK FT KTDFKVVKKLSVIRLLIWAYLSKKDTGIEFADNDRQDIYTLFQQTGRIVHSNLTETFRD FT YIFPGDKTSYWVWLNESIANDADIVLNRHAITMYDKILSYIYSEIKQGRVNKNMLKLVY FT IFEPEKDIRELLLEIIYDIPGDILSIIDAKNDDWKKYFISFYKANFINGNTFISDRTFN FT EDLFRVVVQIDPEYFDNERIMSLFSTSAADIKRFDELDINNSYISNIIYEVNDITLDTM FT DDMKKCQIFNEDTSYYVKEYNTYLFLHESDPMVIENGILKKLSSIKSKSRRLNLFSKNI FT LKYYLDGQLARLGLVLDDYKGDLLVKMINHLKSVEDVSAFVRFSTDKNPSILPSLIKTI FT LASYNISIIVLFQRFLRDNLYHVEEFLDKSIHLTKTDKKYILQLIRHGRS" FT CDS 8361..8861 FT /codon_start=1 FT /note="ORF5" FT /db_xref="GOA:P68446" FT /db_xref="UniProtKB/Swiss-Prot:P68446" FT /protein_id="AAB59827.1" FT /translation="MGTAATIQTPTKLMNKENAEMILEKIVDHIVMYISDESSDSENNP FT EYIDFRNRYEDYRSLIIKSDHEFVKLCKNHAEKSSPETQQMIIKHIYEQYLIPVSEVLL FT KPIMSMGDIITYNGCKDNEWMLEQLSTLNFNNLRTWNSCSIGNVTRLFYTFFSYLMKDK FT LNI" FT CDS 8986..9807 FT /codon_start=1 FT /note="ORF6" FT /db_xref="InterPro:IPR005057" FT /db_xref="UniProtKB/Swiss-Prot:P23372" FT /protein_id="AAB59828.1" FT /translation="MAATVPRFDDVYKNAQRRILDQETFFSRGLSRPLMKNTYLFDNYA FT YGWIPETAIWSSRYANLDASDYYPISLGLLKKFEFLMSLYKGPIPVYEEKVNTEFIANG FT SFSGRYVSYLRKFSALPTNEFISFLLLTSIPIYNILFWFKNTQFDITKHTLFRYVYTDN FT AKHLALARYMHQTGDYKPLFSRLKENYIFTGPVPIGIKDINHPNLSRARSPSDYETLAN FT ISTILYFTKYDPVLMFLLFYVPGYSITTKITPAVEYLMDKLNLTKSDVQLL" FT CDS complement(9814..12834) FT /codon_start=1 FT /product="DNA polymerase" FT /db_xref="GOA:P06856" FT /db_xref="InterPro:IPR006133" FT /db_xref="InterPro:IPR006134" FT /db_xref="InterPro:IPR006172" FT /db_xref="InterPro:IPR012337" FT /db_xref="InterPro:IPR013617" FT /db_xref="InterPro:IPR013660" FT /db_xref="InterPro:IPR017964" FT /db_xref="InterPro:IPR017966" FT /db_xref="UniProtKB/Swiss-Prot:P06856" FT /protein_id="AAB59829.1" FT /translation="MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDE FT IYQSLSPPPFNARPLGKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRSIQNATM FT DEFLNISWFYISNGISPDGCYSLDEQYLTKINNGCYHCDDPRNCFAKKIPRFDIPRSYL FT FLDIECHFDKKFPSVFINPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCL FT RIQSLMEMDYERELVLCSEIVLLRIAKQLLELTFDYVVTFNGHNFDLRYITNRLELLTG FT EKIIFRSPDKKEAVYLCIYERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEK FT LDSYKLDSISKNAFSCMGKVLNRGVREMTFIGDDTTDAKGKAAAFAKVLTTGNYVTVDE FT DIICKVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARY FT CIHDACLCQYLWEYYGVETKTDAGASTYVLPQSMVFEYRASTVIKGPLLKLLLETKTIL FT VRSETKQKFPYEGGKVFAPKQKMFSNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSTN FT RLEEEINNQLLLQKYPPPRYITVHCEPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERA FT RYKKMLKQATSSTEKAIYDSMQYTYKIVANSVYGLMGFRNSALYSYASAKSCTSIGRRM FT ILYLESVLNGAELSNGMLRFANPLSNPFYMDDRDINPIVKTSLPIDYRFRFRSVYGDTD FT SVFTEIDSQDVDKSIEIAKELERLINNRVLFNNFKIEFEAVYKNLIMQSKKKYTTMKYS FT ASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDILRS FT LETDLRSEFDSRSSPLELFMLSRMHHSNYKSADNPNMYLVTEYNKNNPETIELGERYYF FT AYICPANVPWTKKLVNIKTYETIIDRSFKLGSDQRIFYEVYFKRLTSEIVNLLDNKVLC FT ISFFERMFGSKPTFYEA" FT variation complement(11004..>11004) FT /replace="t" FT /note="t in mutant ts46 confers temperature sensitivity FT (Glu-.Lys)" FT /citation=[2] FT variation complement(11660) FT /replace="t" FT /note="t in mutant NG26 confers temperature sensitivity FT (Gly->Asp)" FT /citation=[2] FT variation complement(11720) FT /replace="t" FT /note="t in mutant NG26 (Gly->Asp)" FT /citation=[2] FT CDS 12866..13153 FT /codon_start=1 FT /note="ORF7" FT /db_xref="GOA:P23373" FT /db_xref="InterPro:IPR006890" FT /db_xref="InterPro:IPR017905" FT /db_xref="UniProtKB/Swiss-Prot:P23373" FT /protein_id="AAB59830.1" FT /translation="MNPKHWGRAVWTIIFIVLSQAGLDGNIEACKRKLYTIVSTLPCPA FT CRRHATIAIEDNNVMSSDDLNYIYYFFIRLFNNLASDPKYAIDVTKVNPL" FT CDS complement(13148..13537) FT /codon_start=1 FT /note="ORF8" FT /db_xref="InterPro:IPR009201" FT /db_xref="UniProtKB/Swiss-Prot:P68448" FT /protein_id="AAB59831.1" FT /translation="MELVNIFLETDAGRVKFAIKNTDDVCASELINKFVELLSEYIHID FT QSEFYLVVKDKDIFYFKCDRGSISIVNNEFYVFDEPLLFVKDFTNVTGVEFIVTETMPC FT RIIPKNNHAVISVVTNHKFYNGLSL" XX SQ Sequence 15212 BP; 4992 A; 2561 C; 2400 G; 5259 T; 0 other; aagcttcctg cgtactcaaa gtagataaac cctcatcgcc cgcgtgtgag agaagacctt 60 cgtccccgtc cagatgcgag agaatgaata accctggaaa acaagttccg tttatgagga 120 cggacatgct acaaaatatg ttcgcggcta atcgcgacaa cgtggcgtcg agacttttga 180 actaaaatac aattatatcc ttttcgatat taataaatcc gtgtcgtcca ggttttttat 240 ctctttcagt atgtgaatag ataggtattt tatctctatt catcatcgaa tttaagagat 300 ccgataaaca ttgtttgtat tctccagatg tcagcatctg atacaacaat atatgtgcac 360 ataaacctct ggcacttatt tcatgtacct tccccttatc actaaggaga atagtatttg 420 agaaatatgt atacatgata ttatcatgaa ttagatatac agaatttgta acactctcga 480 aatcacacga tgtgtcggcg ttaagatcta atatatcact cgataacaca ttttcatcta 540 gatacactag acatttttta aagctaaaat agtctttagt agtgacagta actatgcgat 600 tattttcatc gatgatacat ttcatcggca tattattacg cttaccatca aagactatac 660 catgtgtata tctaacgtat tctagcatgg ttgccatacg cgcattaaac ttttcaggat 720 ctttggatag atcttccaat ctatctattt gagaaaacat ttttatcatg ttcaatagtt 780 gaaacgtcgg atccactata tagatattat ctataaagat tttaggaact acgttcatgg 840 tatcctggcg aatattaaaa ctatcaatga tatgattatc gttttcatct tttatcacca 900 tatagtttct aagatatggg attttactta atataatatt atttcccgta ataaatttta 960 ttagaaatgc caaatctata agaaaagttc tagaattagt ctgaagaata tctatatcgc 1020 cgtatagtat atttggatta attagatata gagaatatga tccgtaacat atacaacttt 1080 tattatggcg tctaagatat tcttccatca acttattaac atttttgact agggaagata 1140 cattatgacg tcccattact tttgccttgt ctattactgc gacgttcata gaatttagca 1200 tatctcttgc caattcttcc attgatgtta cattataaga aattttagat gaaattacat 1260 ttggagcttt aatagtaaga actcctaata tgtccgtgta tgtggtcact aatacagatt 1320 gtagttctat aatcgtaaat aatttaccta tattatatgt ttgagtctgt ttagaaaagt 1380 agctaagtat acgatctttt atttctgatg cagatgtatc aacatcggaa aaaaatcttt 1440 ttttattctt ttttactaaa gatacaaata tgtctttgtt aaaaacagtt attttctgaa 1500 tatttctagc ttgtaatttt aacatatgat attcgttcac actaggtact ctgcctaaat 1560 aggtttctat aatctttaat gtaatattag gaaaagtatt ctgatcagga ttcctattca 1620 ttttgaggat ttaaaactct gattattgtc taatatggtc tctacgcaaa ctttttcaca 1680 gagcgataga gtttttgata actcgttttt cttaagaaat ataaaactac tgtctccaga 1740 gctcgctcta tcttttattt tatttaattc gatacaaact cctgatactg gttcagaaag 1800 taattcatta attttcagtc ctttatagaa gatatttaat atagataata caaaattttc 1860 agttcttgat atcgatctga ttgatcctag aactagatat attaataacg tgctcattag 1920 gcagtttatg gcagcttgat aattagatat agtatattcc agttcatatt tattagatac 1980 cgcattgccc agattttgat attctatgaa ttcctctgaa aataaatcca aaataactaa 2040 acattctatt ttttgtggat tagtgtactc tcttccctct atcatgttca ctactggtgt 2100 ccacgatgat aaatatctag agggaatata atatagtcca taggatgcca atctagcaat 2160 gtcgaataac tgtaatttga ttcttcgttc ttcattatga attgattctt gaggtataaa 2220 cctaacacaa attatattat tagacttttc gtatgtaatg tctttcatgt tataagtttt 2280 taatcctgga atagaatcta ttttaatgag gcttttaaac gcagagttct ccaacgagtc 2340 aaagcataat actctgttgt ttttcttata tacgatgtta cgattttctt ctttgaatgg 2400 aataggtttt tgaattagtt tataattaca acataataga taaggaagtg tgcaaatagt 2460 acgcggaaaa aacataatag ctcccctgtt ttcatccatg gttttaagta aatgatcact 2520 ggcttcttta gtcaatggat attcgaacat taaccgtttc atcatcattg gacagaatcc 2580 atatttctta atgtaaagag tgatcaaatc attgtgttta ttgtaccatc ttgttgtaaa 2640 tgtgtattcg gttatcggat ctgctccttt ttctattaaa gtatcgatgt cgatctcgtc 2700 taagaattca actatatcga catatttcat ttgtatacac ataaccatta ctaacgtaga 2760 atgtatagga agagatgtaa cgggaacagg gtttgttgat tcgcaaacta ttctaataca 2820 taattcttct gttaatacgt cttgcacgta atctattata gatgccaaga tatctatata 2880 attattttgt aagatgatgt taactatgtg atctatataa gtagtgtaat aattcatgta 2940 tttcgatata tgttccaact ctgtctttgt gatgtctagt ttcgtaatat ctatagcatc 3000 ctcaaaaaat atattcgcat atattcccaa gtcttcagtt ctatcttcta aaaaatcttc 3060 aacgtatgga atataataat ctattttacc tcttctgata tcattaatga tatagttttt 3120 gacactatct tctgtcaatt gattcttatt cactatatct aagaaacgga tagcgtccct 3180 aggacgaact actgccatta atatctctat tatagcttct ggacataatt catctattat 3240 accagaatta atgggaacta ttccgtatct atctaacata gttttaagaa agtcagaatc 3300 taagacctga tgttcatata ttggttcata catgaaatga tctctattga tgatagtgac 3360 tatttcattc tctgaaaatt ggtaactcat tctatatatg ctttccttgt tgatgaagga 3420 tagaatatac tcaatagaat ttgtaccaac aaactgttct cttatgaatc gtatatcatc 3480 atctgaaata atcatgtaag gcatacattt aacaattaga gacttgtctc ctgttatcaa 3540 tatactattc ttgtgataat ttatgtgtga ggcaaatttg tccacgttct ttaattttgt 3600 tatagtagat atcaaatcca atggagctac agttcttggc ttaaacagat atagtttttc 3660 tggaacgaat tctacaacat tattataaag gactttgggt agataagtgg gatgaaatcc 3720 tattttaatt aatgcgatag ccttgtcctc gtgcagatat ccaaacgctt ttgtgatagt 3780 atggcattca ttgtctagaa acgctctacg aatatctgtg acagatatca tctttagaga 3840 atatactagt cgcgttaata gtactacaat ttgtattttt taatctatct caataaaaaa 3900 attaatatgt atgattcaat gtataactaa actactaact gttattgata actagaatca 3960 gaatctaatg atgacgtaac caagaagttt atctactgcc aatttagctg cattattttt 4020 agcatctcgt ttagattttc catctgcctt atcgaatact cttccgtcga tgtctacaca 4080 ggcataaaat gtaggagagt tactaggccc cactgattca atacgaaaag accaatctct 4140 cctagtaatt tggcagtact cattaataac ggtgacaggg ttagcacctt tccaatcaat 4200 aattttttta gccggaataa catcatcaaa agacttatga tcctctctca ttgatttttc 4260 gcgggataca tcatctatta tgacgtcagc catagcatca gcatccggct tatccgcctc 4320 cgttgtcata aaccaacgag gaggaatatc gtcggagctg tacaccatag cactacgttg 4380 aagatcgtac agagctttat taacttctcg cttctccata ttaagttgtc tagttagttg 4440 tgcagcagta gctccttcga ttccaatggt tttaatagcc tcacacacaa tctctgcgtt 4500 agaacgctcg tcgatataga ttttagacat ttttagagag aactaacgca atcagtaata 4560 aaactaattt attttatcat tttttttatt catcatcctc tggtggttcg tcgtttctat 4620 cgaatgtagc tctgattaac ccgtcatcta taggtgatgc tggttctgga gattctggag 4680 gagatggatt attatctgga agaatctctg ttatttcctt gttttcatgt atcgattgcg 4740 ttgtaacatt aagattgcga aatgctctaa atttgggagg cttaaagtgt tgtttgcaat 4800 ctctacacgc gtgtctaact agtggaggtt cgtcagcggc tctagtttga atcatcatcg 4860 gcgtagtatt cctactttta cagttaggac acggtgtatt gtatttctcg tcgagaacgt 4920 taaaataatc gttgtaactc acatccttta ttttatctat attgtattct actcctttct 4980 taatgcattt tataccgaat aagagatagc gaaggaattc tttttcggtg ccgctagtac 5040 ccttaatcat atcacatagt gttttatatt ccaaatttgt ggcaatagac ggtttatttc 5100 tatacgatag tttgtttctg gaatcctttg agtattctat accaatatta ttctttgatt 5160 cgaatttagt ttcttcgata ttagattttg tattacctat attcttgatg tagtactttg 5220 atgatttttc catggcccat tctattaagt cttccaagtt ggcatcatcc acatattgtg 5280 atagtaattc tcggatatca gtagcggtta ccgccattga tgtttgttca ttggatgagt 5340 aactactaat gtatacattt tccatttata acacttatgt attaactttg ttcatttata 5400 ttttttcatt attatgttga tattaacaaa agtgaatata tatatgttaa taattgtatt 5460 gtggttatac ggctacaatt ttataattag tgaaagtcag tgtccgatga tcaatgacga 5520 tagctttact ctgaaaagaa agtatcaaat cgatagtgcg gagtcaacaa taaaaatgga 5580 taagaagagg acaaagtttc agaatagagc caaaatggta aaagaaataa atcagacaat 5640 aagagcagca caaactcatt acgagacatt gaaactagga tacataaaat ttaagagaat 5700 gattaggact actactctag aagatatagc accatctatt ccaaataatc agaaaactta 5760 taaactattc tcggacattt cagccatcgg caaagcatca cggaatccaa gtaagatggt 5820 atatgctctg ctgctttaca tgtttcccaa tttgtttgga gatgatcata gattcattcg 5880 ttatagaatg catccaatga gtaaaatcaa acacaagatc ttctctcctt tcaaacttaa 5940 tcttattaga atattagtgg aagaaagatt ctataataat gaatgcagat ctaataaatg 6000 gagaataatt ggaacacaag ttgataaaat gttgatagct gaatctgata aatatacaat 6060 agatgcaagg tataacctaa aacccatgta tagaatcaag ggaaaatctg aagaagatac 6120 cctctttatc aaacagatgg tagaacaatg tgtgacatcc caggaattgg tggaaaaagt 6180 gttgaagata ctgtttagag atttgttcaa gagtggagaa tacaaagcgt acagatacga 6240 tgatgatgta gaaaatggat ttattggatt ggatacacta aaattaaaca ttgttcatga 6300 tatagttgaa ccatgtatgc ctgttcgtag gccagtggct aagatactgt gtaaagaaat 6360 ggtaaataaa tactttgaga atccgctaca tattattggt aaaaatcttc aagagtgcat 6420 tgactttgtt agtgaatagg catttcatct ttctccaata ctaattcaaa ttgttaaatt 6480 aataatggat agtataaata gttattagtg ataaaatagt aaaaataatt attagaataa 6540 gagtgtagta tcatagataa ctctcttcta taaaaatgga ttttattcgt agaaagtatc 6600 ttatatacac agtagaaaat aatatagatt ttttaaagga tgatacatta agtaaagtaa 6660 acaattttac cctcaatcat gtactagctc tcaagtatct agttagcaat tttcctcaac 6720 atgttattac taaggatgta ttagctaata ccaatttttt tgttttcata catatggtac 6780 gatgttgtaa agtgtacgaa gcggttttac gacacgcatt tgatgcaccc acgttgtacg 6840 ttaaagcatt gactaagaat tatttatcgt ttagtaacac aatacaatcg tacaaggaaa 6900 ccgtgcataa actaacacaa gatgaaaaat ttttagaggt tgccaaatac atggacgaat 6960 taggagaact tataggcgta aattatgact tagttcttaa tccattattt cacggagggg 7020 aacccatcaa agatatggaa atcatttttt taaaactgtt taagaaaaca gacttcaaag 7080 ttgttaaaaa attaagtgtt ataagattac ttatttgggc ttacctaagc aagaaagata 7140 caggcataga gtttgcggat aatgatagac aagatatata tactctattt caacaaactg 7200 gtagaatcgt ccatagcaat ctaacagaaa cgtttagaga ttatatcttt cccggagata 7260 agactagcta ttgggtgtgg ttaaacgaaa gtatagctaa tgatgcggat attgttctta 7320 atagacacgc cattaccatg tatgataaaa ttcttagtta tatatactct gagataaaac 7380 agggacgcgt taataaaaac atgcttaagt tagtttatat ctttgagcct gaaaaagata 7440 tcagagaact tctgctagaa atcatatatg atattcctgg agatatccta tctattattg 7500 atgcaaaaaa cgacgattgg aaaaaatatt ttattagttt ttataaagct aattttatta 7560 acggtaatac atttattagt gatagaacgt ttaacgagga cttattcaga gttgttgttc 7620 aaatagatcc cgaatatttc gataatgaac gaattatgtc tttattctct acgagtgctg 7680 cggacattaa acgatttgat gagttagata ttaataacag ttatatatct aatataattt 7740 atgaggtgaa cgatatcaca ttagatacaa tggatgatat gaagaagtgt caaatcttta 7800 acgaggatac gtcgtattat gttaaggaat acaatacata cctgtttttg cacgagtcgg 7860 atcccatggt catagagaac ggaatactaa agaaactgtc atctataaaa tccaagagta 7920 gacggctgaa cttgtttagc aaaaacattt taaaatatta tttagacgga caattggctc 7980 gtctaggtct tgtgttagat gattataaag gagacttgtt agttaaaatg ataaaccatc 8040 ttaagtctgt ggaggatgta tccgcattcg ttcgattttc tacagataaa aaccctagta 8100 ttcttccatc gctaatcaaa actattttag ctagttataa tatttccatc atcgtcttat 8160 ttcaaaggtt tttaagagat aatctatatc atgtagaaga attcttggat aaaagcatcc 8220 atctaaccaa gacggataag aaatatatac ttcaattgat aagacacggt agatcataga 8280 acagaccaaa tatattatta ataatttgta tatacataga tataattatc acatattaaa 8340 aattcacaca tttttgataa atgggaactg ctgcaacaat tcagactccc accaaattaa 8400 tgaataaaga aaatgcagaa atgattttgg aaaaaattgt tgatcatata gttatgtata 8460 ttagtgacga atcaagtgat tcagaaaata atcctgaata tattgatttt cgtaacagat 8520 acgaagacta tagatctctc attataaaaa gtgatcacga gtttgtaaag ctatgtaaaa 8580 atcatgcaga gaaaagttct ccagaaacgc aacaaatgat tatcaaacac atatacgaac 8640 aatatcttat tccagtatct gaagtactat taaaacctat aatgtccatg ggtgacataa 8700 ttacatataa cggatgtaaa gacaatgaat ggatgctaga acaactctct accctaaact 8760 ttaacaatct ccgcacatgg aactcatgta gcataggcaa tgtaacgcgt ctgttttata 8820 cattttttag ttatctgatg aaagataaac taaatatata agtataatcc cattctaata 8880 ctttaacctg atgtattagc atcttattag aatattaacc taactaaaag acataacata 8940 aaaactcatt acatagttga taaaaagcgg taggatataa atattatggc tgccaccgtt 9000 ccgcgttttg acgacgtgta caaaaatgca caaagaagaa ttctagatca agaaacattt 9060 tttagtagag gtctaagtag accgttaatg aaaaacacat atctatttga taattacgcg 9120 tatggatgga taccagaaac tgcaatttgg agtagtagat acgcaaactt agatgcaagt 9180 gactattatc ccatttcgtt gggattactt aaaaagttcg agtttctcat gtctctatat 9240 aaaggtccta ttccagtata cgaagaaaaa gtaaatactg aattcattgc taatggatcg 9300 ttctctggta gatacgtatc atatcttcga aagttttctg ctcttccaac aaacgagttt 9360 attagttttt tgttactgac ttccattcca atctataata tcttgttctg gtttaaaaat 9420 actcagtttg atattactaa acacacatta ttcagatacg tctatacaga taatgccaaa 9480 cacctggcgt tggctaggta tatgcatcaa acaggagact ataagccttt gtttagtcgt 9540 ctcaaagaga attatatatt taccggtccc gttccaatag gtatcaaaga tataaatcac 9600 cctaatctta gtagagcaag aagtccatcc gattatgaga cattagctaa tattagtact 9660 atattgtact ttaccaagta tgatccggta ttaatgtttt tattgtttta cgtacctggg 9720 tattcaatta ctacaaaaat tactccagcc gtagaatatc taatggataa actgaatcta 9780 acaaagagcg acgtacaact gttgtaaatt attttatgct tcgtaaaatg taggttttga 9840 accaaacatt ctttcaaaga atgagatgca taaaacttta ttatccaata gattgactat 9900 ttcggacgtc aatcgtttaa agtaaacttc gtaaaatatt ctttgatcac tgccgagttt 9960 aaaacttcta tcgataattg tttcatatgt tttaatattt acaagttttt tggtccatgg 10020 tacattagcc ggacaaatat atgcaaaata atatcgttct ccaagttcta tagtttctgg 10080 attattttta ttatattcag taaccaaata catattaggg ttatctgcgg atttataatt 10140 tgagtgatgc attcgactca acataaataa ttctagagga gacgatctac tatcaaattc 10200 ggatcgtaaa tctgtttcta aagaacggag aatatctata catacctgat tagaattcat 10260 ccgtccttca gacaacatct cagacagtct ggtcttgtat gtcttaatca tattcttatg 10320 aaacttggaa acatctcttc tagtttcact agtaccttta ttaattctct caggtacaga 10380 ttttgaattc gacgatgccg agtatttcat cgttgtatat ttcttcttcg attgcataat 10440 cagattctta tataccgcct caaactctat tttaaaatta ttaaacaata ctctattatt 10500 aatcagtcgt tctaactcct ttgctatttc tatggactta tctacatctt gactgtctat 10560 ctctgtaaac acggagtcgg tatctccata cacgctacga aaacgaaatc tgtaatctat 10620 aggcaacgat gttttcacaa tcggattaat atctctatcg tccatataaa atggattact 10680 taatggattg gcaaaccgta acataccgtt agataactct gctccattta gtaccgattc 10740 tagatacaag atcattctac gtcctatgga tgtgcaactc ttagccgaag cgtatgagta 10800 tagagcacta tttctaaatc ccatcagacc atatactgag ttggctacta tcttgtacgt 10860 atattgcatg gaatcataga tggccttttc agttgaactg gtagcctgtt ttaacatctt 10920 tttatatctg gctctctctg ccaaaaatgt tcttaatagt ctaggaatgg ttccttctat 10980 cgatctatcg aaaattgcta tttcagagat gaggttcggt agtctaggtt cacaatgaac 11040 cgtaatatat ctaggaggtg gatatttctg aagcaagagc tgattattta tttcttcttc 11100 caatctattg gtactaacaa cgacaccgac taatgtttcc ggagatagat ttccaaagat 11160 acacacatta ggatacagac tgttataatc aaagattaat acattattac taaacatttt 11220 ttgttttgga gcaaatacct taccgccttc ataaggaaac ttttgttttg tttctgatct 11280 aactaagata gttttagttt ccaacaatag ctttaacagt ggacccttga tgactgtact 11340 cgctctatat tcgaatacca tggattgagg aagcacatat gttgacgcac ccgcgtctgt 11400 ttttgtttct actccataat actcccacaa atactgacac aaacaagcat catgaataca 11460 gtatctagcc atatctaaag ctatgtttag attataatcc ttatacatct gagctaaatc 11520 aacgtcatcc tttccgaaag ataatttata tgtatcatta ggtaaagtag gacataatag 11580 tacgacttta aatccatttt cccaaatatc tttacgaatt actttacata taatatcctc 11640 atcaacagtc acataattac ctgtggttaa aacctttgca aatgcagcgg ctttgccttt 11700 cgcgtccgta gtatcgtcac cgatgaacgt catttctcta actcctctat ttaatacttt 11760 acccatgcaa ctgaacgcgt tcttggatat agaatccaat ttgtacgaat ccaatttttc 11820 agatttttga atgaatgaat atagatcgaa aaatatagtt ccattattgt tattaacgtg 11880 aaacgtagta ttggccatgc cgcctactcc cttatgacta gactgatttc tctcataaat 11940 acagagatat acagcttcct ttttgtccgg agatctaaag ataatcttct ctcctgttaa 12000 taactctaga cgattagtaa tatatctcag atcaaagtta tgtccgttaa aggtaacgac 12060 atagtcgaac gttagttcca acaattgttt agctattcgt aacaaaacta tttcagaaca 12120 taaaactagt tctcgttcgt aatccatttc cattagtgac tgtatcctca aacatcctct 12180 atcgacggct tcttgtattt cctgttccgt taacatctct tcattaatga gcgtaaacaa 12240 taatcgttta ccacttaaat cgatataaca gtaacttgta tgcgagattg ggttaataaa 12300 tacagaagga aacttcttat cgaagtgaca ctctatatct agaaataagt acgatcttgg 12360 gatatcgaat ctaggtattt ttttagcgaa acagttacgt ggatcgtcac aatgataaca 12420 tccattgtta atctttgtca aatattgctc gtccaacgag taacatccgt ctggagatat 12480 cccgttagaa atataaaacc aactaatatt gagaaattca tccatggtgg cattttgtat 12540 gctgcgtttc tttggctctt ctatcaacca catatctgcg acggagcatt ttctatcttt 12600 aatatctaga ttataactta ttgtctcgtc aatgtctata gttctcatct ttcccaacgg 12660 cctcgcatta aatggaggag gagacaatga ctgatatatt tcgtccgtca ctacgtaata 12720 aaagtaatga ggaaatcgta taaatacggt ctcaccattt cgacatctgg atttcagata 12780 taaaaatctg ttttcaccgt gactttcaaa ccaattaatg caccgaacat ccatttatag 12840 aatttagaaa tatattttca tttaaatgaa tcccaaacat tggggaagag ccgtatggac 12900 cattattttt atagtacttt cgcaagcggg tttagacggc aacatagaag cgtgtaaacg 12960 aaaactatat actatagtta gcactcttcc atgtcctgca tgtagacggc acgcgactat 13020 cgctatagag gacaataatg tcatgtctag cgatgatctg aattatattt attatttttt 13080 catcagatta tttaacaatt tggcatctga tcccaaatac gcgatcgatg tgacaaaggt 13140 taacccttta taaacttaac ccattataaa acttatgatt agtcacgact gaaataaccg 13200 cgtgattatt ttttggtata attctacacg gcatggtttc tgtgactatg aattcaaccc 13260 ccgttacatt agtgaaatct ttaacaaaca gcaagggttc gtcaaagaca taaaactcat 13320 tgtttacaat cgaaatagac cccctatcac acttaaaata aaaaatatcc ttatccttta 13380 ccaccaaata aaattctgat tggtcaatgt gaatgtattc acttaacagt tccacaaatt 13440 tatttattaa ctccgaggca catacatcgt cggtattttt tatggcaaac tttactcttc 13500 cagcatccgt ttctaaaaaa atattaacga gttccattta tatcatccaa tattattgaa 13560 atgacgttga tggacaaatg atacaaataa gaaggtacgg tacctttgtc caccatctcc 13620 tccaattcat gctctatttt gtcattaact ttaatgtatg aaaacagtac gccacatgct 13680 tccatgacag tgtgtaacac tttggataca aaatgtttga cattagtata attgttcaag 13740 actgtcaatc tataatagat agtagctata atatattcta tgatggtatt gaagaagatg 13800 acaaccttgg catattgatc atttaacaca gacatggtat caacagatag cttgaatgaa 13860 agagaatcag taattggaat aagcgtcttc tcgatggagt gtccgtatac caacatgtct 13920 gatattttga tgtattccat taaattattt agttttttct ttttattctc gttaaacagc 13980 atttctgtca acggacccca acatcgttga ccgattaagt tttgattgat ttttccgtgt 14040 aaggcgtatc tagtcagatc gtatagccta tccaataatc catcgtctgt gtgtagatca 14100 catcgtacac tttttaattc tctatagaag agcgacagac atctggagca attacagaca 14160 gcaatttctt tattctctac agatgtaaga tacttgaaga cattcctatg atgatgcaga 14220 attttggata acacggtatt gatggtatct gttaccataa ttcctttgat ggctgatagt 14280 gtcagagcac aagatttcca atctttgaca atttttagca ccattatctt tgttttgata 14340 tctatatcag acagcatggt gcgtctgaca acacaaggat taagacggaa agatgaaatg 14400 attctctcaa catcttcaat ggataccttg ctattttttc tggcattatc tatatgtgcg 14460 agaatatcct ctagagaatc agtatccttt ttgatgatag tggatctcaa tgacatggga 14520 cgtctaaacc ttcttattct atcaccagat tgcatggtga tttgtcttct ttcttttatc 14580 ataatgtaat ctctaaattc atcggcaaat tgtctatatc taaaatcata atatgagatg 14640 tttacctcta caaatatctg ttcgtccaat gttagagtat ttacatcagt tttgtattcc 14700 aaattaaaca tggcaacgga tttaatttta tattcctcta ttaagtcctc gtcgataata 14760 acagaatgta gataatcatt taatccatcg tacatggttg gaagatgctt gttgacaaaa 14820 tctttaattg tcttgatgaa ggtgggacta tatctaacat cttgattaat aaaatttata 14880 acattgtcca taggatactt tgtaactagt tttatacaca tctcttcatc ggtaagccca 14940 gacagaatat cgtgaacagg tggtatatta tattcatcag atatacgaag aacaatgtcc 15000 aaatctatat tgtttaatat attatataga tgtagtgtag ctcctacagg aatatcttta 15060 actaagtcaa tgatttcatc aaccgttaga tctattttaa agttaatcat ataggcattg 15120 atttttaaaa ggtatgtagc cttgactaca ttctcattaa ttaaccattc caagtcactg 15180 tgtgtaagaa gattatattc tatcataagc tt 15212 // |
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