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EBIDatabasesDatabase BrowsingDbfetch

EBI Dbfetch

ID   M19237; SV 1; linear; genomic DNA; STD; VRL; 684 BP.
XX
AC   M19237;
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DT   16-JUL-1988 (Rel. 16, Created)
DT   17-APR-2005 (Rel. 83, Last updated, Version 3)
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DE   Herpesvirus saimiri dihydrofolate reductase (DHFR) gene, complete cds.
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KW   dihydrofolate reductase.
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OS   Saimiriine herpesvirus 2 (Herpesvirus saimiri)
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Gammaherpesvirinae; Rhadinovirus.
XX
RN   [1]
RP   1-684
RX   DOI; 10.1126/science.2830673
RX   PUBMED; 2830673.
RA   Trimble J.J., Murthy S.C.S., Bakker A., Grassmann R., Desrosiers R.C.;
RT   "A gene for dihydrofolate reductase in a herpesvirus";
RL   Science 239(4844):1145-1147(1988).
XX
CC   Submitted in computer readable form by J.J.Trimble 02-MAY-1988;
CC   Dihydrofolate reductase catalyzes the reduction of dihydrofolate to
CC   tetrahydrofolate, an essential step for de novo glycine and purine
CC   synthesis, DNA precursor synthesis,  and for the conversion of
CC   deoxyuridine monophosphate to deoxythymidine monophosphate (dTMP).
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..684
FT                   /organism="Saimiriine herpesvirus 2"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:10381"
FT   CDS             31..594
FT                   /codon_start=1
FT                   /note="DHFR (dihydrofolate reductase) (EC 1.5.1.3)"
FT                   /db_xref="GOA:P09503"
FT                   /db_xref="HSSP:1DHF"
FT                   /db_xref="InterPro:IPR017925"
FT                   /db_xref="UniProtKB/Swiss-Prot:P09503"
FT                   /protein_id="AAA46154.1"
FT                   /translation="MVQALNCIVAVAQNMGIGKQGNLPWPRLMNDFKHFQRMTTTSSVP
FT                   DKQNLVIMGKKTWFSIPEKNRPLKGRINVVLSKELKELPHRAHFLAKSLDDALKLTEQP
FT                   ELANKVDMVWIIGGSSVYKEAMSYPCDLKLFVTRIMQDFECDTFFPEFDLEKYKLLIEY
FT                   PSVLSNVQEEKSIKYKFEVYEKNH"
XX
SQ   Sequence 684 BP; 241 A; 102 C; 129 G; 212 T; 0 other;
     ctagagaaga agaagtcttt agttagtatt atggttcaag cactaaactg cattgttgct        60
     gtagctcaaa acatgggcat tggcaaacaa ggtaacttgc cttggccaag acttatgaat       120
     gattttaaac atttccaaag aatgactact acatcttctg taccagataa acagaattta       180
     gtgattatgg gtaaaaagac ttggttctca attcctgaga agaaccggcc tttaaaaggc       240
     agaattaatg ttgttctcag caaggaacta aaggagcttc cacatagagc tcatttttta       300
     gctaagagtt tagatgatgc tttaaaactt accgaacagc cagaattagc aaataaagta       360
     gacatggtct ggataattgg aggtagttct gtgtataaag aagctatgag ttatccatgc       420
     gatcttaaac tgtttgtgac taggatcatg caagactttg aatgtgacac cttttttcca       480
     gaatttgatc tagagaaata caaacttttg atagaatatc caagtgttct ttctaatgtg       540
     caagaagaga aaagtattaa gtacaaattt gaagtatatg agaagaatca ttaatacaaa       600
     tgtcttttac aggtgaagat gtcatgtatt tgtgaaaact tacatataca ttataaattc       660
     acacaactct atcagctttt agta                                              684
//
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