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EBI DbfetchID M15621; SV 1; linear; genomic DNA; STD; VRL; 7241 BP. XX AC M15621; XX DT 02-APR-1988 (Rel. 15, Created) DT 04-MAR-2000 (Rel. 63, Last updated, Version 2) XX DE HSV1 (strain F) alpha-trans-inducing factor genes, complete cds. XX KW alpha-trans-inducing factor. XX OS Human herpesvirus 1 (Herpes simplex virus type 1) OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Alphaherpesvirinae; Simplexvirus. XX RN [1] RP 1-7241 RA Jenkins F.J.; RT ; RL Unpublished. XX RN [2] RP 2375-7241 RX PUBMED; 3029433. RA McKnight J.L.C., Pellett P.E., Jenkins F.J., Roizman B.; RT "Characterization and nucleotide sequence of two herpes simplex virus 1 RT genes whose products modulate alpha-trans-inducing factor-dependent RT activation of alpha genes"; RL J. Virol. 61(4):992-1001(1987). XX CC Draft entry and computer-readable copy of sequence in [1] kindly CC provided by F.J.Jenkins, 11-MAY-1987. CC TATA boxes for 70.5 kb and 77 kb polypeptides are located at CC positions 2578-2583 and 4888-4890 respectively. A polyadenlation CC signal is found at bases 7173-7178. This poly-A signal is shared by CC both mRNAs. XX FH Key Location/Qualifiers FH FT source 1..7241 FT /organism="Human herpesvirus 1" FT /mol_type="genomic DNA" FT /db_xref="taxon:10298" FT mRNA 2606..7194 FT /note="ATIF (70.5 kb) mRNA (5' enf +/- 5 bp, 3' end +/- 3 FT bp)" FT CDS 2801..4795 FT /codon_start=1 FT /note="alpha trans-inducing factor 70.5kb" FT /db_xref="GOA:P08313" FT /db_xref="InterPro:IPR005029" FT /db_xref="UniProtKB/Swiss-Prot:P08313" FT /protein_id="AAA45767.1" FT /translation="MSAREPAGRRRRASTRPRASPVADEPAGDGVGFMGYLRAVFRGDD FT DSELEALEEMAGDEPPVRRRREGPRARRRRASEAPPTSHRRASRQRPGPDAARSQSVRG FT RLDDDDEVPRGPPQARQGGYLGPVDARAILGRVGGSRVAPSPLFLEELQYEEDDYPEDV FT GPEDGGGARSPPKVEVLEGRVPGPELRAAFPLDRLAPQVAVWDESVRSALALGHPAGFY FT PCPDSAFGLSRVGVMHFASPDNPAVFFRQTLQQGEALAWYITGDGILDLTDRRTKTSPA FT QAMSFLADAVVRLAINGWVCGTRLHAEARGSDLDDRAAELRRQFASLTALRPVGAAAVP FT LLSAGGLVSPQSGPDAAVFRSSLGSLLYWPGVRALLDRDCRVAARYAGRMTYLATGALL FT ARFNPDAVRCVLTREAAFLGRVLDVLAVMAEQTVHVALGGRGGAPAPARAPPAFADVAR FT EELFRALPLGSPAVVGAEHEALGDTAARRLLANSGLNAVLGAAVYALHTALATVTLKYA FT RACGDAHRRRDDAAATRRILAAGLVLQRLLGFADTVVACVTLAAFDGDSRPPRWARTPP FT CYACVLRATQPLYARTTPAKFWADVRAAAEHVDLRPASSAPRAPVSGTADPAFLLKDLE FT PFPPAPVSGGSVLGPGSAWWTSCPSLGNC" FT mRNA 4914..7194 FT /note="ATIF (77 kb) mRNA (5' end +/- 3 bp, 3' end +/- 3 FT bp)" FT CDS 4961..7108 FT /codon_start=1 FT /note="alpha trans-inducing factor 77kb" FT /db_xref="GOA:P08314" FT /db_xref="InterPro:IPR005051" FT /db_xref="UniProtKB/Swiss-Prot:P08314" FT /protein_id="AAA45768.1" FT /translation="MQRRTRGASSLRLARCLTPANLIRGDNAGVPERRIFGGCLLPTPE FT GLLSAAVGALRQRSDDAQPAFLTCTDRSVRLAARQHNTVPESLIVDGLASDPHYEYIRH FT YASAATQALGEVELTGGQLSRAILTQYWKYLQTVVPSGLDVPEDPVGDCDPSLHVLLRP FT TLAPKLLARTPFKSGAAAAKYAATVAGLRDALHRIQQYMFFMRPADPSRPSTDTALRLN FT ELLAYVSVLYRWASWMLWTTDKHVCHRLSPSNRRFLPLGGSPEAPAETFARHLDRGPSG FT TTGSMQCMALRAAVSDVLGHLTRLANLWQTGKRSGGTYGTVDTVVSTVEVLSIVHHHAQ FT YIINATLTGYGVWATDSLNNEYLRAAVDSQERFCRTTAPLFPTMTAPSWARMELSIKAW FT FGAALAADLLRSGAPSLHYESILRLVASRRTTWSAGPPPDDMARGPGGHRAGGGTVGKR FT FSGPARQRAPAPPPTSPTLDPRGHPAVPEAPRGRPAPPLPDADDPVAEPPGCAAQPATY FT YTHMGEVPPRLPARNVAGPDRRPPAATCPLLVRRASLGSLDRPRGWGPAPEGEPDQMEA FT TYLTADDDDDARRKATHAASARERHAPYEDDESIYETVSEDGGRVYEEIPWMRVYENVC FT ANTANAAPASPYIEAENPLYDWGGSALFSPPPRPPPPPPLSPSPVLARHRANALTNDGP FT TNVAALSALLTKLKREGRRSR" XX SQ Sequence 7241 BP; 1088 A; 2570 C; 2419 G; 1164 T; 0 other; gtcgacgcgc caacccgatc caagacaccc gcgcagggct ggccagaaag ctgcacttta 60 gcaccgcccc cccaaacccc gacgcgccat ggaccccccg ggtggccggc tttaacaagc 120 gcgtcttctg cgccgcggtc gggccgctgg cggccatgca tgcccggatg gcggcggtcc 180 agctctggga catgtcgcgt ccgcgcacag acgaagacct caacgaactc cttggcatca 240 ccaccatccg cgtgacggtc tgcgagggca aaaacctgct tcagcgcgcc aacgagttgg 300 tgaatccaga cgtggtgcag gacgtcgacg cggccacggc gactcgaggg cgttctgcgg 360 cgtcgcgccc caccgagcga cctcgagccc cagcccgctc cgcttctcgc cccagacggc 420 ccgtcgagtg aaaaacttcc gtacccagac aataaagcac caacaggggt tcattcggtg 480 ttggcgttgc gtgcctttgt ttcccaatcc gacggggacc gtgactgggt ggcggggggt 540 gggttggaca gccgccctcg gttcgccttc acgtgacagg agccaatgtg gggggaagtc 600 acgaggtacg gggcggccgt gcgggttgct taaatgcggg gtggcgacca cgggctgtca 660 ttcctcggga acggacgggg ttcccgctgc ccacttcccc ccataaggtc cgtccggtcc 720 tctaacgcgt ttgggggttt ttctcttccc gcgccgtcgg cgtcccacac tctctgggcg 780 ggcggggacg atcgcatcaa aagcccgata tcgtctttcc cgtatcaacc ccacccaatg 840 gacctcttgg tcgacgagct gtttgccgac atggacgcgg acggcgcttc gccaccaccc 900 ccccgcccgg ccgggggtcc caaaaacacc ccggcggccc ctccgctgta cgcaacgggg 960 cgcctgagcc aggcccagct catgccctcc ccgcccatgc ccgtcccccc cgccgccctc 1020 tttaaccgtc tcctcgacga cttgggcttt agcgcgggcc ccgcgctatg taccatgctc 1080 gatacctgga acgaggattt gttttcggcg ttaccgacca acgccgacct gtaccgggag 1140 tgtaaattcc tatcaacgct gcccagcgat gtggtggaat ggggggacgc gtacgtcccc 1200 gaacgcgccc aaatcgacat tcgcgcccac ggcgacgtgg ccttcccgac gcttccggcc 1260 acccgcgacg gcctcgggct ctactacgaa gcgctctctc gtttcttcca cgccgagcta 1320 cgggcgcggg aggagagcta tcgaaccgtg ttggccaact tctgctcggc cctgtaccgg 1380 tacctgcgcg ccagcgtccg gcagctgcac cgccaggcgc acatgcgcgg acgcgatcgc 1440 gacctgggag aaatgctgcg cgccacgatc gcggacaggt actaccgaga gaccgctcgt 1500 ctggcgcgtg ttctgttttt gcatttgtat ctatttttga cccgcgagat cctatgggcc 1560 gcgtacgccg agcagatgat gcggcccgac ctgtttgact gcctctgttg cgacctggag 1620 agctggcgtc agttggcggg tctgttccag cccttcatgt tcgtcaacgg agcgctcacc 1680 gtccggggag tgccaatcga ggcccgccgg ctgcgggagc taaaccacat tcgcgagcac 1740 cttaacctcc cgctggtgcg cagcgcggct acggaggagc caggggcgcc gttgacgacc 1800 cctcccaccc tgcatggcaa ccaggcccgc gcctctgggt actttatggt gttgattcgg 1860 gcgaagttgg actcgtattc cagcttcacg acctcgccct ccgaggcggt catgcgggaa 1920 cacgcgtaca gccgcgcgcg tacgaaaaac aattacgggt ctaccatcga gggcctgctc 1980 gatctcccgg acgacgacgc ccccgaagag gcggggctgg cggctccgcg cctgtccttt 2040 ctccccgcgg gacacacgcg cagactgtcg acggcccccc cgaccgatgt cagcctgggg 2100 gacgagctcc acttagacgg cgaggacgtg gcgatggcgc atgccgacgc gctagacgat 2160 ttcgatctgg acatgttggg ggacggggat tccccgggtc cgggatttac cccccacgac 2220 tccgccccct acggcgctct ggatatggcc gacttcgagt ttgagcagat gtttaccgat 2280 gcccttggaa ttgacgagta cggtgggtag ggggcgcgac cggacccgca tcccccgtct 2340 gggttttccc ctcccgtccc cggttcgtat ccacaataaa cacgagcaca tacattacaa 2400 aaacctgcgg ttgtcgtctg attatttggt ggtggggaaa agaactagcc aggagacggg 2460 accgcgcaac caacccactg gggtctgggt tgccggcgtg tgtgttagcc gcgtctgcgg 2520 gcctgtcgtg tagattcgaa accacggacg ggtgattgtg tcgcagggcg gcccgcgtat 2580 aaaggcgaga gcgcgggacc gtttccgcat ttggccgggg gctggggcgg cgggtagcct 2640 tcgcgggaga tactgcgttt tttgcgccgg ccccgtcgct cccgtccatt cccatcgcga 2700 gggggtccgg cggcacctac cccggcctcc atccgcgctg tggggtcttt ttcttttttg 2760 gggggtagcg gacatccgat aacccgcgtc tatcgccacc atgtcggctc gcgaacccgc 2820 ggggcgtagg aggcgcgcat ccacccgccc ccgcgcctcg cccgtggcgg acgagccagc 2880 gggcgatggg gtggggttca tggggtacct gcgtgcggtg ttccgcgggg atgacgacag 2940 cgagctagag gctctggagg agatggcggg cgacgagccg cccgtgcgcc gtcgacggga 3000 aggcccgcga gcccgacgac ggcgcgcgtc ggaagccccg cccacatccc atcgccgagc 3060 gtcccggcag cgccccgggc ccgatgcggc ccgtagccag tcggtgcgcg gtcgcctgga 3120 cgatgatgat gaggttcccc gcggtcctcc gcaggcccgg caggggggat acctgggtcc 3180 cgtcgacgcg cgggctattt tggggcgggt cggcggttcg cgggtggcgc cgtcgccgct 3240 gttcctagag gagctgcagt acgaggagga cgactacccg gaagacgtcg ggccggagga 3300 cggcggcggg gcccgttccc cgcccaaggt ggaggttctg gagggacgcg tgccgggccc 3360 ggagctccgg gcggcattcc cgttggatcg actggcccct caggttgccg tgtgggacga 3420 gtccgtgcgc tccgccctag ccctggggca tccggccggg ttttacccgt gtccggatag 3480 cgcgttcggg ttatcgcgcg tgggggtcat gcacttcgcc tcccccgaca accccgcggt 3540 gtttttccgc caaaccctgc agcagggcga ggcgttggcc tggtatatca cgggcgatgg 3600 gattcttgac ctgacggatc gtcgaacaaa aaccagcccc gcccaggcga tgagcttttt 3660 ggcggatgcc gtcgtgcggc tggccatcaa cgggtgggtg tgcgggacgc gccttcacgc 3720 agaggcgcgc gggtcggacc tggacgacag ggctgccgag ctgaggcggc agttcgcgag 3780 cctcacggcg ttgcgtcccg tcggggccgc ggccgtgccg ttactgagcg cgggggggtt 3840 agtgtccccc caatccggcc ccgacgccgc ggtgtttcgc agctcgctgg ggtccctgct 3900 gtactggccc ggggtgcgcg cgctgctgga ccgcgactgt cgcgtggccg cccgctatgc 3960 cggccgcatg acgtacctgg ccaccggggc cctgctcgcc cgcttcaatc ccgacgccgt 4020 ccggtgcgtt ttgacgcggg aggccgcctt cctggggcgc gtgctggatg tgctggcggt 4080 gatggcggag cagacggtcc acgtggctct cggtggtcgt gggggcgcgc ctgcacccgc 4140 acgtgcacca cccgcctttg cggacgtggc gcgggaggag ctgtttcgcg ccctgcccct 4200 gggaagcccc gcggtcgtgg gggccgagca cgaggcgctg ggcgacaccg cagcgcgccg 4260 gctgctcgcc aacagcgggc tcaacgccgt gctgggcgct gcggtgtacg cgctgcacac 4320 ggccctggcg accgtgacct taaagtacgc ccgggcgtgc ggggacgcgc accggcgccg 4380 ggacgacgcg gcggccacgc gccgcattct ggccgccggg ctcgtcctgc agcggctgct 4440 gggctttgcc gacaccgtgg tggcgtgcgt gacactggcc gcgtttgacg gggattcacg 4500 gcccccgagg tgggcacgta cacccccctg ctacgcgtgc gtcctccgag cgacccagcc 4560 cctgtacgcg cgcaccaccc ccgccaagtt ctgggcggac gtccgcgcgg ccgcggagca 4620 cgtggatctg cgccccgcct cctcagcgcc ccgggccccc gtgtccggga cggcagaccc 4680 cgcctttctt ctcaaggacc tggagccctt cccccccgcc cccgtaagcg gcgggtccgt 4740 gttgggcccg gggtccgcgt ggtggacatc atgtcccagt ttaggaaact gctgatggga 4800 gacgaggggg ccgccgcctg cgggcgcacg tgtcggggag gcgcgcgacc gggctgggag 4860 gcccgccacg cccataagct cctcccgata aaaagcgccc cgatggccct ggacgcggca 4920 taactccgac cggcgggtac ccgaccgaac gggcgtcacc atgcagcgcc ggacgcgcgg 4980 cgcgagctcc ctgcggctgg cgcggtgcct gacgcctgcc aacctgatcc gcggcgacaa 5040 cgcgggcgtt cccgagcggc gcatcttcgg cgggtgtctg ctccccaccc cggaggggct 5100 ccttagcgcg gccgtgggcg ccttgcggca gcgctccgac gacgcgcagc cggcgtttct 5160 gacctgcacc gatcgcagcg tccggttggc cgcgcggcaa cacaacacgg ttcccgagag 5220 tttgatcgtg gacgggctcg ccagcgaccc gcactacgag tacatccggc actacgcttc 5280 ggccgccacc caggcgctgg gcgaggtgga gctcaccggc ggccagttga gccgcgccat 5340 cctcacgcag tactggaagt acctgcagac ggtggtgccc agcggcctgg acgtccccga 5400 ggaccccgtg ggcgactgcg accccagcct tcacgtgctg ctgcggccca ccctggcgcc 5460 aaagctgctg gcgcgcaccc cgttcaagag cggggccgcg gcggccaagt acgccgccac 5520 cgtggccggc ctgcgcgacg ccctccatcg gattcagcag tacatgttct ttatgcgccc 5580 ggcggaccca agccgcccca gcaccgacac cgcactgcgg ctcaacgagc tcctggccta 5640 cgtctccgtg ctgtaccggt gggcgtcctg gatgctgtgg acgacagaca agcacgtatg 5700 ccaccggctg agtccctcca atcgccggtt cctcccgctc ggcggcagcc cggaggcgcc 5760 cgcggaaacg ttcgcgcgcc atctggaccg gggtcccagc ggcacgaccg gctccatgca 5820 gtgcatggcg ctcagggcgg cggtcagcga cgtcctgggc cacctgacgc gcctagccaa 5880 cctgtggcag accggcaagc ggagcggcgg tacgtacggg accgtggata ccgtcgtatc 5940 cacggtggag gttctgtcga tcgtccatca ccacgcccag tatatcatca acgcgaccct 6000 caccgggtac ggcgtctggg ccaccgacag cctgaacaac gagtatctgc gggccgcggt 6060 ggacagccag gagcgtttct gtcggaccac cgcccccctg ttccccacga tgaccgcccc 6120 cagctgggcc cggatggagt tgagcatcaa ggcttggttc ggggccgccc tggccgcgga 6180 tctgctccgc agcggggcgc cgtcgctcca ctacgagtcc atcctgcggc tcgtggcgtc 6240 tcgccggacg acgtggtccg cggggcctcc cccggacgac atggcccgcg gcccgggggg 6300 gcatcgcgcg gggggtggga ctgtcgggaa aagattcagc gggccggcgc gacaacgagc 6360 ccccgcccct cccccgacct cgcctacact cgacccccgc ggccacccgg cggttccgga 6420 ggcgccgcgc ggacggccgg cgcccccgct tccggatgcg gacgacccgg tcgccgagcc 6480 ccccggctgc gccgcacagc cggccacgta ttacacgcac atgggggagg tgcccccgcg 6540 cctcccggcc cgtaacgtcg cgggacccga caggcgaccg ccggcggcga cgtgccccct 6600 cctcgtccgg cgcgcgtctc tggggagcct cgatcggcca cgggggtggg gacccgcccc 6660 ggagggagaa cccgaccaga tggaagccac gtatctgacg gccgacgacg acgacgacgc 6720 ccgccgcaaa gccacccacg ccgcctcggc ccgcgaacgg cacgccccct acgaggacga 6780 cgagtcaata tacgagactg tgagcgagga cggggggcgt gtctacgagg aaataccatg 6840 gatgcgggtc tacgaaaacg tctgcgcgaa cacggcgaat gcagcgccgg cctccccgta 6900 cattgaggcg gaaaatcccc tgtacgactg ggggggatcc gccctatttt cccccccgcc 6960 gcgaccgccc ccgcccccgc cgttgagccc ctcgcccgtc ctcgcccgcc atcgagccaa 7020 cgccctgacc aacgacggcc cgaccaacgt cgccgccctg agcgccctcc tgaccaagct 7080 taaacgcgaa ggacgccgga gccggtgaac gcctccaccc gtgctgccgt cgctagacca 7140 cgcccctttc cccctgtttg acgacgagat ttaataaaaa taaccaaaaa caccacaggg 7200 gaccgcgtgt tctttttatc gcacgtgatt gtgtgtttat t 7241 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