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EBI DbfetchID M12700; SV 1; linear; genomic DNA; STD; VRL; 5956 BP. XX AC M12700; K02023; K02911; XX DT 25-APR-1990 (Rel. 23, Created) DT 28-OCT-2005 (Rel. 85, Last updated, Version 5) XX DE Human herpesvirus 2 ribonucleotide reductase large subunit and 38K protein DE genes, complete cds; and 58K protein gene, partial cds. XX KW . XX OS Human herpesvirus 2 (Herpes simplex virus type 2) OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Alphaherpesvirinae; Simplexvirus. XX RN [1] RP 3360-5249 RX PUBMED; 6321759. RA Galloway D.A., Swain M.A.; RT "Organization of the left-hand end of the herpes simplex virus type 2 BglII RT N fragment"; RL J. Virol. 49(3):724-730(1984). XX RN [2] RP 3894-3963, 4900-4969, 5153-5222 RX PUBMED; 6092683. RA Draper K.G., Frink R.J., Devi G.B., Swain M., Galloway D., Wagner E.K.; RT "Herpes simplex virus types 1 and 2 homology in the region between 0.58 and RT 0.68 map units"; RL J. Virol. 52(2):615-623(1984). XX RN [3] RP 5165-5956 RX DOI; 10.1073/pnas.81.15.4736 RX PUBMED; 6087345. RA Galloway D.A., Nelson J.A., McDougall J.K.; RT "Small fragments of herpesvirus DNA with transforming activity contain RT insertion sequence-like structures"; RL Proc. Natl. Acad. Sci. U.S.A. 81(15):4736-4740(1984). XX RN [4] RP 1-3998 RX PUBMED; 2419588. RA Swain M.A., Galloway D.A.; RT "Herpes simplex virus specifies two subunits of ribonucleotide reductase RT encoded by 3'-coterminal transcripts"; RL J. Virol. 57(3):802-808(1986). XX RN [5] RP 1-5956 RA Swain M.A.; RT ; RL Submitted (04-NOV-1986) to the EMBL/GenBank/DDBJ databases. RL Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA XX CC Original source text: Herpes simplex virus type 2 (strain 333) DNA CC [4]; clone pDG401, fragment BC24 [3]; clone pP2 (derivative of CC pDG401) [1]. CC [5] revises [3]. Draft entry and sequence in computer readable form CC for [3], [1], [2], [4] and [5] kindly provided by M.A.Swain, CC 04-NOV-1986. An insertion-like sequence is present from position CC 5482-5627 [3]. A TATA box for the 5.0 kb mRNA is located at CC positions 148-153 and a TATA box for the 1.2 kb mRNA is located at CC positions 3742-3747. A poly-adenylation signal for the 5.0 kb and CC 1.2 kb mRNAs is found at positions 4954-4959. XX FH Key Location/Qualifiers FH FT source 1..5956 FT /organism="Human herpesvirus 2" FT /strain="333" FT /mol_type="genomic DNA" FT /db_xref="taxon:10310" FT mRNA 176..>5000 FT /product="5.0 kb mRNA" FT CDS 419..3853 FT /codon_start=1 FT /product="ribonucleotide reductase large subunit" FT /note="140K" FT /db_xref="GOA:P09853" FT /db_xref="InterPro:IPR000788" FT /db_xref="UniProtKB/Swiss-Prot:P09853" FT /protein_id="AAA45806.1" FT /translation="MANRPAASALAGARSPSERQEPREPEVAPPGGDHVFCRKVSGVMV FT LSSDPPGPAAYRISDSSFVQCGSNCSMIIDGDVARGHLRDLEGATSTGAFVAISNVAAG FT GDGRTAVVALGGTSGPSATTSVGTQTSGEFLHGNPRTPEPQGPQAVPPPPPPPFPWGHE FT CCARRDARGGAEKDVGAAESWSDGPSSDSETEDSDSSDEDTGSGSETLSRSSSIWAAGA FT TDDDDSDSDSRSDDSVQPDVVVRRRWSDGPAPVAFPKPRRPGDSPGNPGLGAGTGPGSA FT TDPRASADSDSAAHAAAPQADVAPVLDSQPTVGTDPGYPVPLELTPENAEAVARFLGDA FT VDREPALMLEYFCRCAREESKRVPPRTFGSAPRLTEDDFGLLNYALAEMRRLCLDLPPV FT PPNAYTPYHLREYATRLVNGFKPLVRRSARLYRILGILVHLRIRTREASFEEWMRSKEV FT DLDFGLTERLREHEAQLMILAQALNPYDCLIHSTPNTLVERGLQSALKYEEFYLKRFGG FT HYMESVFQMYTRIAGFLACRATRGMRHIALGRQGSWWEMFKFFFHRLYDHQIVPSTPAM FT LNLGTRNYYTSSCYLVNPQATTNQATLRAITGNVSAILARNGGIGLCMQAFNDASPGTA FT SIMPALKVLDSLVAAHNKQSTRPTGACVYLEPWHSDVRAVLRMKGVLAGEEAQRCDNIF FT SALWMPDLFFKRLIRHLDGEKNVTWSLFDRDTSMSLADFHGEEFEKLYEHLEAMGFGET FT IPIQDLAYAIVRSAATTGSPFIMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPSSKRSS FT GVCNLGSVNLARCVSRRTFDFGMLRDAVQACVLMVNIMIDSTLQPTPQCARGHDNLRSM FT GIGMQGLHTACLKMGLDLESAEFRDLNTHIAEVMLLAAMKTSNALCVRGARPFSHFKRS FT MYRAGRFHWERFSNASPRYEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGF FT APLFTNLFSKVTRDGETLRPNTLLLKELERTFGGKRLLDAMDGLEAKQWSVAQALPCLD FT PAHPLRRFKTAFDYDQELLIDLCADRAPYVDHSQSMTLYVTEKADGTLPASTLVRLLVH FT AYKRGLKTGMYYCKVRKATNSGVFAGDDNIVCTSCAL" FT mRNA 3769..>4900 FT /product="1.2 kb mRNA" FT CDS 3906..4919 FT /codon_start=1 FT /product="38K protein" FT /db_xref="GOA:P69520" FT /db_xref="InterPro:IPR000358" FT /db_xref="UniProtKB/Swiss-Prot:P69520" FT /protein_id="AAA45807.1" FT /translation="MDPAVSPASTDPLDTHASGAGAAPIPVCPTPERYFYTSQCPDINH FT LRSLSILNRWLETELVFVGDEEDVSKLSEGELGFYRFLFAFLSAADDLVTENLGGLSGL FT FEQKDILHYYVEQECIEVVHSRVYNIIQLVLFHNNDQARRAYVARTINHPAIRVKVDWL FT EARVRECDSIPEKFILMILIEGVFFAASFAAIAYLRTNNLLRVTCQSNDLISRDEAVHT FT TASCYIYNNYLGGHAKPEAARVYRLFREAVDIEIGFIRSQAPTDSSILSPGALAAIENY FT VRFSADRLLGLIHMQPLYSAPAPDASFPLSLMSTDKHTNFFECRSTSYAGAVVNDL" FT CDS complement(5202..>5956) FT /codon_start=3 FT /product="58K protein" FT /db_xref="GOA:Q69083" FT /db_xref="InterPro:IPR002927" FT /db_xref="UniProtKB/TrEMBL:Q69083" FT /protein_id="AAA45808.1" FT /translation="AGYFKMSYPQFLALFVRCHTDLHPNNTYASVEDVLRECHWTAPSR FT SQARRAARRERANSRSLESMPTLTAAPVGLETRISWTEILAQQIAGEDDYEEDPPLQPP FT DVAGGPRDGARSSSSEILTPPELVQVPNAQRVAEHRGYVAGRRRHVIHDAPEALDWLPD FT PMTIAELVEHRYVKYVISLISPKERGPWTLLKRLPIYQDLRDEDLARSIVTRHITAPDI FT ADRFLAQLWAHAPPPAFYKDVLAKFWDE" XX SQ Sequence 5956 BP; 1043 A; 2047 C; 1846 G; 1020 T; 0 other; gtgtgtttgg cgtgtgtctc tgaaatggcg gaaaccgaca tgcaaatggg attcatggac 60 acgttacacc cccctgactc aggagatagg catatcctcc ttagattgac tcagcacacg 120 atcgcacccc acccctgtgt gccggggata aaagccaacg cgggcggtct gggttaccac 180 aacaggtggg tgcttcgggg acttgacggt cgccactctc ctgcgagccc tcacgtcttc 240 gcccaccgat tcctgttgcg ttcctgtcgg ccggtgctgt cctgtcgaca gattgttggc 300 gactgcccgg gtgattcgtc ggccggtgcg tcctttcggt cgtaccgccc accccgcctc 360 ccacgggccc gccgctgttt ccgttcatcg cgtccgagcc accgtcacct tggttccaat 420 ggccaaccgc cctgccgcat ccgccctcgc cggagcgcgg tctccgtccg aacgacagga 480 accccgggag cccgaggtcg ccccccctgg cggcgaccac gtgttttgca ggaaagtcag 540 cggcgtgatg gtgctttcca gcgatccccc cggccccgcg gcctaccgca ttagcgacag 600 cagctttgtt caatgcggct ccaactgcag tatgataatc gacggagacg tggcgcgcgg 660 tcatttgcgt gacctcgagg gcgctacgtc caccggcgcc ttcgtcgcga tctcaaacgt 720 cgcagccggc ggggatggcc gaaccgccgt cgtggcgctc ggcggaacct cgggcccgtc 780 cgcgactaca tccgtgggga cccagacgtc cggggagttc ctccacggga acccaaggac 840 ccccgaaccc caaggacccc aggctgtccc cccgccccct cctcccccct ttccatgggg 900 ccacgagtgc tgcgcccgtc gcgatgccag gggcggcgcc gagaaggacg tcggggccgc 960 ggagtcatgg tcagacggcc cgtcgtccga ctccgaaacg gaggactcgg actcctcgga 1020 cgaggatacg ggctcgggtt cggagacgct gtctcgatcc tcttcgatct gggccgcagg 1080 ggcgactgac gacgatgaca gcgactccga ctcgcggtcg gacgactccg tgcagcccga 1140 cgttgtcgtt cgtcgcagat ggagcgacgg ccctgccccc gtggcctttc ccaagccccg 1200 gcgccccggc gactcccccg gaaaccccgg cctgggcgcc ggcaccgggc cgggctccgc 1260 gacggacccg cgcgcgtcgg ccgactccga ttccgcggcc cacgccgccg caccccaggc 1320 ggacgtggcg ccggttctgg acagccagcc cactgtggga acggaccccg gctacccagt 1380 ccccctagaa ctcacgcccg agaacgcgga ggcggtggcg cggtttctgg gggacgccgt 1440 cgaccgcgag cccgcgctca tgctggagta cttctgtcgg tgcgcccgcg aggagagcaa 1500 gcgcgtgccc ccacgaacct tcggcagcgc cccccgcctc acggaggacg actttgggct 1560 cctgaactac gcgctcgctg agatgcgacg cctgtgcctg gaccttcccc cggtcccccc 1620 caacgcatac acgccctatc atctgaggga gtatgcgacg cggctggtta acgggttcaa 1680 acccctggtg cggcggtccg cccgcctgta tcgcatcctg gggattctgg ttcacctgcg 1740 catccgtacc cgggaggcct cctttgagga atggatgcgc tccaaggagg tggacctgga 1800 cttcgggctg acggaaaggc ttcgcgaaca cgaggcccag ctaatgatcc tggcccaggc 1860 cctgaacccc tacgactgtc tgatccacag caccccgaac acgctcgtcg agcgggggct 1920 gcagtcggcg ctgaagtacg aagagtttta cctcaagcgc ttcggcgggc actacatgga 1980 gtccgtcttc cagatgtaca cccgcatcgc cgggttcctg gcgtgccggg cgacccgcgg 2040 catgcgccac atcgccctgg ggcgacaggg gtcgtggtgg gaaatgttca agttcttttt 2100 ccaccgcctc tacgaccacc agatcgtgcc gtccaccccc gccatgctga acctcggaac 2160 ccgcaactac tacacgtcca gctgctacct ggtaaacccc caggccacca ctaaccaggc 2220 caccctccgg gccatcaccg gcaacgtgag cgccatcctc gcccgcaacg ggggcatcgg 2280 gctgtgcatg caggcgttca acgacgccag ccccggcacc gccagcatca tgccggccct 2340 gaaggtcctg gactccctgg tggcggcgca caacaaacag agcacgcgcc ccaccggggc 2400 gtgcgtgtac ctggaaccct ggcacagcga cgttcgggcc gtgctcagaa tgaagggcgt 2460 cctcgccggc gaggaggccc agcgctgcga caacatcttc agcgccctct ggatgccgga 2520 cctgttcttc aagcgcctga tccgccacct cgacggcgag aaaaacgtca cctggtccct 2580 gttcgaccgg gacaccagca tgtcgctcgc cgactttcac ggcgaggagt tcgagaagct 2640 gtacgagcac ctcgaggcca tggggttcgg cgaaacgatc cccatccagg acctggcgta 2700 cgccatcgtg cgcagcgcgg ccaccaccgg aagccccttc atcatgttta aggacgcggt 2760 aaaccgccac tacatctacg acacgcaagg ggcggccatt gccggctcca acctctgcac 2820 ggagatcgtc cacccgtcct ccaaacgctc cagcggggtc tgcaacctgg gcagcgtgaa 2880 tctggcccga tgcgtctccc ggcggacgtt cgattttggc atgctccgcg acgccgtgca 2940 ggcgtgcgtg ctaatggtta atatcatgat agacagcacg ctgcagccga cgccccagtg 3000 cgcccgcggc cacgacaacc tgcggtccat gggcattggc atgcagggcc tgcacacggc 3060 gtgcctgaag atgggcctgg atctggagtc ggccgagttc cgggacctga acacacacat 3120 cgccgaggtg atgctgctcg cggccatgaa gaccagtaac gcgctgtgcg ttcgcggggc 3180 gcgtcccttc agccacttta agcgcagcat gtaccgggcc ggccgctttc actgggagcg 3240 cttttcgaac gccagcccgc ggtacgaggg cgagtgggag atgctacgcc agagcatgat 3300 gaaacacggc ctgcgcaaca gccagttcat cgcgctcatg cccaccgccg cctcggccca 3360 gatctcggac gtcagcgagg gctttgcccc cctgttcacc aacctgttca gcaaggtgac 3420 cagggacggc gagacgctgc gccccaacac gctcttgctg aaggaactcg agcgcacgtt 3480 cggcgggaag cggctcctgg acgcgatgga cgggctcgag gccaagcagt ggtctgtggc 3540 ccaggccctg ccttgcctgg accccgccca ccccctccgg cggttcaaga cggccttcga 3600 ctacgaccag gaactgctga tcgacctgtg tgcagaccgc gccccctatg ttgatcacag 3660 ccaatccatg actctgtatg tcacagagaa ggcggacggg acgctccccg cctccaccct 3720 ggtccgcctt ctcgtccacg catataagcg cggcctgaag acggggatgt actactgcaa 3780 ggttcgcaag gcgaccaaca gcggggtgtt cgccggcgac gacaacatcg tctgcacaag 3840 ctgcgcgctg taagcaacag cgctccgatc ggggtcaggc gtcgctctcg gtcccgcata 3900 tcgccatgga tcccgccgtc tcccccgcga gcaccgaccc cctagatacc cacgcgtcgg 3960 gggccggggc ggccccgatt ccggtgtgcc ccacccccga gcggtacttc tacacctccc 4020 agtgccccga catcaaccac cttcgctccc tcagcatcct gaaccgctgg ctggagaccg 4080 agctcgtgtt cgtgggggac gaggaggacg tctccaagct ctccgagggc gagctcggct 4140 tctaccgctt tctgtttgcc ttcctgtcgg ccgcggacga cctggtgacg gaaaacctgg 4200 gcggcctctc cggcctcttc gaacagaagg acattcttca ctactacgtg gagcaggaat 4260 gcatcgaggt cgtccactcg cgcgtctaca acatcatcca gctggtgctc tttcacaaca 4320 acgaccaggc gcgccgcgcc tatgtggccc gcaccatcaa ccacccggcc attcgcgtca 4380 aggtggactg gctggaggcg cgggtgcggg aatgcgactc gatcccggag aagttcatcc 4440 tcatgatcct catcgagggc gtcttttttg ccgcctcgtt cgccgccatc gcgtacctgc 4500 gcaccaacaa cctcctgcgg gtcacctgcc agtcgaacga cctcatcagc cgcgacgagg 4560 ccgtgcatac gacagcctcg tgctacatct acaacaacta cctcgggggc cacgccaagc 4620 ccgaggcggc gcgcgtgtac cggctgtttc gggaggcggt ggatatcgag atcgggttca 4680 tccgatccca ggccccgacg gacagctcta tcctgagtcc gggggccctg gcggccatcg 4740 agaactacgt gcgattcagc gcggatcgcc tgctgggcct gatccatatg cagcccctgt 4800 attccgcccc cgcccccgac gccagctttc ccctcagcct catgtccacc gacaaacaca 4860 ccaacttctt cgagtgccgc agcacctcgt acgccggggc cgtcgtcaac gatctgtgag 4920 ggtctgggcg cccttgtagc gatgtctaac cgaaataaag gggtcgaaac ggactgttgg 4980 gtctccggtg tgattattac gcaggggagg ggggtggcgg ctggggaaag ggaaggaacg 5040 cccgaaacca gagaaaagga ccaaaaggga aacgcgtcca accgataaat caagcgccga 5100 ccagaacccc gagatgcata ataacaaacg attttattac tcttattatt aacaggtcgg 5160 gcatcgggag gggatggggg cgcgcgtttc ctccgttccg gctactcgtc ccagaattta 5220 gccaggacgt ccttgtaaaa cgcgggcggg ggcgcgtggg cccacagctg cgccagaaac 5280 cggtcggcga tgtccggggc ggtgatatgc cgagtcacga tggagcgcgc taaatcttcg 5340 tcgcggaggt cctgatagat gggcagtctt tttagaagag tccagggtcc ccgctccttg 5400 gggctgataa gcgatatgac gtacttgacg tatctgtgct ccaccagctc ggcgatggtc 5460 atcggatcgg gcagccagtc cagggcctcc ggggcgtcgt ggatgacgtg gcggcgacgt 5520 ccggcgacat agccgcggtg ttccgcgacc cgctgcgcgt tggggacctg cacgagctcg 5580 ggcggggtga gtatctccga ggaggacgac cgggcgccgt cgcgcggccc accggcgacg 5640 tccgggggct ggaggggggg gtcttcttcg tagtcgtcct cgcccgcgat ctgttgggcc 5700 agaatttcgg tccacgagat gcgcgtctcg aggccgaccg gggccgcggt cagcgtaggc 5760 atgctctcca gggagcgcga gttggcgcgc tcccgccggg ccgcccggcg ggcctgggat 5820 cggctcgggg cggtccagtg acactcgcgc agcacgtcct cgacggacgc gtaggtgtta 5880 ttggggtgca ggtctgtgtg gcagcggacg aacagcgcca ggaactgcgg gtaactcatc 5940 ttgaagtacc ctgcag 5956 // |
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