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EBI DbfetchID M10066; SV 1; linear; mRNA; STD; VRT; 6563 BP. XX AC M10066; M13881; XX DT 18-NOV-1986 (Rel. 10, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 3) XX DE Chicken c-erbB oncogene mRNA activated by ALV insertion, producing a DE gag-env-erbB fusion protein. XX KW c-myc proto-oncogene; erbB gene; erbB oncogene; proviral gene. XX OS Gallus gallus (chicken) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; OC Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. XX RN [1] RP 1-6563 RA Nilsen T.W., Maroney P.A., Goodwin R.G., Rottman F.M., Crittenden L.B., RA Raines M.A., Kung H.-J.; RT ; RL Unpublished. XX RN [2] RP 1-3311 RX DOI; 10.1016/S0092-8674(85)80052-0 RX PUBMED; 2988784. RA Nilsen T.W., Maroney P.A., Goodwin R.G., Rottman F.M., Crittenden L.B., RA Raines M.A., Kung H.-J.; RT "c-erbB activation in ALV-induced erythroblastosis: novel RNA processing RT and promoter insertion result in expression of an amino-truncated EGF RT receptor"; RL Cell 41(3):719-726(1985). XX RN [3] RP 1-6563 RX PUBMED; 3023963. RA Goodwin R.G., Rottman F.M., Callaghan T., Kung H.-J., Maroney P.A., RA Nilsen T.W.; RT "c-erbB activation in avian leukosis virus-induced erythroblastosis: RT multiple epidermal growth factor receptor mRNAs are generated by RT alternative RNA processing"; RL Mol. Cell. Biol. 6(9):3128-3133(1986). XX DR Ensembl-Gn; ENSGALG00000012363; Gallus_gallus. DR Ensembl-Tr; ENSGALT00000016218; Gallus_gallus. XX CC Draft entry and computer-readable sequence for [2],[1] kindly CC provided by T.W.Nilsen 09-DEC-1985. CC Chicken leukemic sample 208 was shown to have an integrated avian CC leukosis virus similar to Rous sarcoma virus located approximately CC 100 bp upstream of the 5' end of c-erbB homology to v-erbB. Sample CC 208 produces two v-erbB-related mRNAs of 7.0 and 3.6 kb as well as CC two LTR-containing transcripts of 8.0 and 3.1 kb. The mRNA CC sequence reported here is derived from ALV proviral DNA on the 5' CC end and chicken c-erbB DNA on the 3' end. Positions 1-11 are CC derived from the ALV U5 region, positions 309-326 are derived from CC the first 6 codons of the ALV gag gene, positions 327-484 are CC derived from the first 53 codons of the ALV env gene, and positions CC 485-6563 are derived from the chicken c-erbB gene. Thus the CC protein product is a gag-env-erbB fusion protein containing 59 of CC the 62 amino acids present in the signal peptide of the ALV env CC protein fused to the COOH terminal portion of the c-erbB protein. A CC poly-A signal is present at position 3292-3297. XX FH Key Location/Qualifiers FH FT source 1..6563 FT /organism="Gallus gallus" FT /mol_type="mRNA" FT /db_xref="taxon:9031" FT mRNA 1..3311 FT /note="gag-env-erbB mRNA (alt.) [2]" FT mRNA 1..6563 FT /note="gag-env-erbB mRNA (alt.) [1]" FT CDS 309..2405 FT /codon_start=1 FT /note="gag-env-erbB fusion protein" FT /db_xref="GOA:P00534" FT /db_xref="HSSP:1M17" FT /db_xref="InterPro:IPR008266" FT /db_xref="UniProtKB/Swiss-Prot:P00534" FT /protein_id="AAA48763.1" FT /translation="MEAVIKAFLTGYPGETSKKDSKKKPPATSKKDPEKTPLLPTRVNY FT ILIIGVLVLCEVTGGPDHCMKCAHFIDGPHCVKACPAGVLGENDTLVWKYADANAVCQL FT CHPNCTRGCKGPGLEGCPNGSKTPSIAAGVVGGLLCLVVVGLGIGLYLRRRHIVRKRTL FT RRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKVKVLGSGAFGTVYKGLWIPEGEKV FT KIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGC FT LLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVKITDF FT GLAKLLGADEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY FT DGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIAEFSKMARD FT PPRYLVIQGDERMHLPSPTDSKFYRTLMEEEDMEDIVDADEYLVPHQGFFNSPSTSRTP FT LLSSLSATSNNSATNCIDRNGQGHPVREDSFVQRYSSDPTGNFLEESIDDGFLPAPEYV FT NQLMPKKPSTAMVQNQIYNNISLTAISKLPMDSRYQNSHSTAVDNPEYLNTNQSPLAKT FT VFESSPYWIQSGNHQINLDNPDYQQDFLPNETKPNGLLKVPAAENPEYLRVAAPKSEYI FT EASA" XX SQ Sequence 6563 BP; 1918 A; 1405 C; 1481 G; 1759 T; 0 other; aaggcttcat ttggtgaccc cgacgtgatc gttagggaat agtggtcggc cacagacggc 60 gtggcgatcc tgtcctcatc cgtctcgctt attcggggag cggacgatga ccctagtaga 120 gggggctgcg gcttaggagg gcagaagctg agtggcgtcg gagggagctc tactgcaggg 180 agccaacata ccctaccgag aactcagaga gtcgttggaa gacgggaagg aagcccgacg 240 actgagcggt ccaccccagg cgtgattccg gttgctctgc gtgattccgg tcgcccggtg 300 gatcaagcat ggaagccgtc ataaaggcat ttctgactgg ataccctggg gagacaagca 360 agaaggactc caagaagaag ccgccagcaa caagcaagaa ggacccggag aagacaccct 420 tgctgccaac gagagttaac tatattctca tcattggtgt cctggtcctg tgtgaggtta 480 cggggggccc agaccactgc atgaagtgtg cccattttat agatggtccc cactgtgtga 540 aggcctgccc cgctggggtc ctgggtgaga atgataccct ggtctggaag tatgcagatg 600 ccaatgctgt ttgccagctc tgccatccaa actgtacacg agggtgcaaa ggaccaggtc 660 ttgaaggatg tccaaatggc tctaaaactc catctatcgc ggctggtgtt gtcggaggac 720 tcctgtgcct ggttgtggtt ggtctaggca tcggtcttta cctgcggcga cgtcatatcg 780 tgcggaagcg caccctgcgc aggctgctgc aagagaggga gcttgtcgaa ccactgacac 840 ccagtgggga ggcaccaaac caggcccacc tgagaatttt aaaggaaaca gaatttaaaa 900 aggtcaaagt tttgggctct ggagcttttg gcactgttta taagggactt tggatcccag 960 aaggggaaaa ggttaaaatt cctgttgcta ttaaagaatt gagagaggct acatcgccaa 1020 aagccaacaa ggaaatactt gatgaagcct atgtgatggc tagtgttgac aatcctcatg 1080 tgtgccgctt gctgggaatc tgcctcactt ccactgtgca gctcatcacc cagcttatgc 1140 cttatggctg cctccttgac tacatccgag agcacaagga caacattggc tcccagtacc 1200 ttctcaactg gtgtgtgcag attgcaaagg gaatgaacta cctggaggaa cgtcgcctgg 1260 tgcaccgtga ccttgctgcc aggaacgtcc ttgttaagac tccacaacat gtgaaaatca 1320 cagactttgg gctggcaaag ctgcttgggg cagatgagaa ggagtatcac gcagagggag 1380 gcaaggttcc tattaaatgg atggcattgg agtcaatttt acaccgaatt tatactcatc 1440 aaagtgatgt ctggagttat ggtgtgacag tttgggagtt gatgacattt gggtccaagc 1500 cttatgacgg gatccccgca agtgaaatct cctccgtctt ggagaaggga gagcgtttgc 1560 cccagccacc catttgtacc attgatgtgt acatgatcat ggtcaaatgc tggatgattg 1620 atgcagacag ccgtcccaag tttcgtgagc tgattgcaga gttctccaaa atggctcgtg 1680 accctccccg ctatcttgtt atacagggag atgaaaggat gcacttgcct agccctacag 1740 attccaagtt ttatcgcacc ctgatggagg aggaggacat ggaagacatt gtggatgcag 1800 atgagtatct tgtcccacac cagggctttt tcaacagccc ctctacatct cggactcctc 1860 ttctgagttc attgagcgct actagcaaca attctgctac aaactgcatt gacagaaatg 1920 ggcaggggca ccctgtgagg gaagacagct ttgtccagag gtacagctca gatccaacag 1980 ggaacttctt ggaggagagt atagatgatg gcttcctgcc tgctccagag tatgtaaacc 2040 agctgatgcc caagaaacca tctactgcca tggtccagaa tcaaatctac aacaacatct 2100 ctctcacagc aatctcaaag ctccccatgg actcaagata ccagaattcc cacagcacag 2160 ctgtggacaa ccctgagtat ctcaacacta accagtcccc actggccaaa acagtcttcg 2220 agagctctcc ctattggatc caatcaggca atcaccaaat aaatctggac aatcctgact 2280 accagcagga ctttttacca aatgaaacaa aacctaatgg tctcttgaaa gttcctgcag 2340 cagaaaaccc agagtacttg agggtagcag caccaaaaag tgaatacatt gaagcttcag 2400 catgaccaca gaggatttct tcttgcagtg aggcaagcca gactggtgaa ttgcctggct 2460 gctgtaagaa caaactctgt tcagcgcgaa tggcaaccac aatgcatcaa taagcacact 2520 tcagcacgca atctgaatct gcaaagccaa tctcacagga cagtttgggt cttttcttgc 2580 ccatttccat gtatagctga agcccatacg ctgcactgag atgtgtgttg aaatagagcg 2640 ggatcttcct gtacagaaaa aatatggatg cattcctttc cttttcaaat ggtagcatgg 2700 taagaagcca ctctgggatg aacttgtgaa ctgtacactc tatacagtca aattcctttc 2760 tacaatgcgt atttttataa atgttcctaa cagatttttt ggatcagatg cttgtactgc 2820 ttgtctgtta gttggtgatc agatcaccag cgggaaaaaa aaaacgttac taaatagttt 2880 tccaaaagtc ctggaacaga aacagttatt ccaaaccaca ggacttttac aaaatggctc 2940 cacatactcc atcttggcat gaacagaaaa agggcatctg gtggatgtat gggagattct 3000 gtctatggca ggatgaagca gattattatg gggaaaacta gcccaaggag tgaatggcac 3060 gacacatcac caactgacca ctgctgctaa aaactgacag gaggaataca gctcacaata 3120 atttgtagat ttttactcac tggtctgttt tctgattgta aaacacaagg tgtttttctg 3180 atgtgttatg ctgttgtaga attgtcaaaa tgcctctctt cttcaacaaa actgctaaag 3240 atgttcccat aactgaaaaa ttaagtgtca aataatgctt tacagactct aattaaatgt 3300 caaggaaatg caaatggttg caaattggag ccttcatgag acagacagga agactgatac 3360 taaattaaac ttgagtaagg gaagaaacac aggtagctct agccaagtag tctcttttag 3420 agactcagaa acctttttgc ctacatttgg caaagaaaat agtaatgccc atgttagcat 3480 tttcctcact tcaagacaaa atatggccat cacgccaggg cagagactag ggctgtttgc 3540 ctcactgtac ctttcccact ggggtgacct cttgcatccc aaggcaatgc tagagggtca 3600 gtgagcatgg gtttgggaaa ggaagagtaa tctaggatgg tggaaaaagg ttgccttcct 3660 cttatgaaac acagagcttc ccattgcttc ttcaaaatac ccagcctagg cttctgtttt 3720 cagtgtggaa gaggcagact agctaaggtt aaggttttaa cttaatagta taaatactct 3780 gtatactgat agtgtgtcag taacaggagc caaagcaggt actctttcaa gggttccatg 3840 ttacagaact taaaactcct ctaacaatga catttcttat gaaggcagta ggagtaaaat 3900 gtgtgacttt ccagcagctt ggcagcagcg caattttaat caaaccatta gttcagaaat 3960 caaaggcatg ttcatcaatt ttagaacata gtttttacag atctaccaag gagtgaaaga 4020 gtggtcctgt gaaatgaccc tttttatagg taatgcagtg aaaaaaacat cagcagtttc 4080 tgtctgtgca gcagttcatc agctgccttt cagtttgagg tagagaagtg catttagtca 4140 aaatccaagg gttttcctgg tgtgctattt catagatttg tgtcactgag atgtgagtcc 4200 cagccacagt gctatgggga gtgcagtgtc tgactttggt tattgttggt ttgtgtttaa 4260 aacaataatt gaaatttagt tcccatgtcc aaccaaatct gccaatgcaa ggagaaatct 4320 gtcgcagatt tctctttgca ttcctgagag cacatttgtt ctgctgctct caaaagcagt 4380 acgaatgcac aggcagtgct tttctgccca cccactcccc caagaggaat gtaaataaaa 4440 ccaaaatgta ttttaacaga aagcacagat aattttcagt tcactaaatc tgttctgtct 4500 ccaagcagaa tactagaaaa tcatacagtg catgtcctcc catagcaaat ttccaacagc 4560 attacatgga agtatgtatt gatgttttaa tctgtcatcc aaaacaagaa agacactaag 4620 agagagcaat atctgtaacc agtgctatgt agcattaaaa ttgttcaatt ctggttagtt 4680 tgcttgtcct tctaaagcca ttcaggagga attcagtaga gacttattac tagaaacagg 4740 gaaatacatc taaaatttat tttcatatat atatatattt aatgagaaca gtaggaaaga 4800 ggctttagtt cttgttaaaa atttacagga agattccaga tttgtgggat tagctgtgtt 4860 gtgaaataat tccactaaat atgcaccctt taagccatga tttgtaaaca ggcagctcag 4920 taatgattaa aaagtcagca aaatttttaa aaaaatggac agtgcctcaa ggggcagata 4980 ctggggcatt aggggtgaat gagactgtgc agctgcaact ggttgttgtt gaaggcatgt 5040 gtgctacaca gggtactgct tttgggtaac aggcattagc aaggtaccca acaattgtca 5100 ctgaaaaaat aatcaataag cagctgaaat gctttttgtc ttgttttttc ttcccactgc 5160 aggtcactga ccatgtaaca gcaagtagcc tcataggtgc tggtaaagcc aaactaggtc 5220 aggcaacact ttcacaggaa tcacggcacc ttgctgatgc agcgctgtac aaaatgcagg 5280 ctactgaatg ggacatagaa gttgtggatt tacaactttt atgaaactaa atattagaat 5340 tttattttct aaatactaga aaaaaataaa ggtcctgcat cttgacagct tacatacatt 5400 agcacccaaa aataacttga aagctctgcc attgtctctc aggatatctg ggtataaaac 5460 actgatttta aaaacacaac tagtgtaaca gaccacaacc actggtaaaa gctgctttac 5520 aatccagaaa ataaaacttc tcttttcact gtatttctca tggaaggcaa aatgacacca 5580 ctcacaagtt agtgtctctt aatcataaag cagaagttag tgacaaactg ttttaaataa 5640 taatttaagc actgcatgct tggatatgaa aatgtaagtc acatcaagat tcttcatgtt 5700 actttgatgt tttccagcaa cctgtgcacg gtgttggtgc acttcacttg ggcctcgggt 5760 tgttttcttc tgctgcaaag gaaattggct tgggaattct cctacataag gcattacaaa 5820 atatactccc ggagtttact tgagaggaat gggagagtag tgccaggctg agggcagaca 5880 gccaatccat atctgagaca gctgccgaat ttgcaatgga ttgttcttgc aggtatgggt 5940 gggaatagct acatagatgg ctcctctccc tgcttccacc ttggagagaa gtcctctata 6000 tttctagaga gactgtgcaa aaagcagtgt tcagcctctg tgcttcagga tgaccttcat 6060 cccaaccttg gaggtgtacc tggggctgtg gcagtgtctg tgccctcaca cagtgtctac 6120 agtgtcctca ggctgtctgg gtaccaatga gaaatccagg gtaccaatga gaaactgcat 6180 ttccagacaa gcgctcattt ttcagattca gagttccaac ttcttctatt agtatgactg 6240 tctctccaga tgaggagtta caaaatgcca gcttttattt ctgcccatgc ttctctggaa 6300 gaaatagtcc gaatcaggac aaagtatgaa aatatacctg tgtcctccct cctgatgaaa 6360 accgtatact gatgaagcat caaactctgc atgtaacact tagcaacaat gctttgtaac 6420 gttttatcac cactcaatcg attttctata ttgaaattcc attttctagt gttctttttg 6480 taagtttcat ctctttgttc caacatacaa gcttttaagg agacttttta aaaaataata 6540 gaaaaataaa gtttatacat aag 6563 // |
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