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EBI DbfetchID L06418; SV 4; linear; genomic DNA; STD; PRO; 7634 BP. XX AC L06418; M67992; M69220; X15369; XX DT 07-JAN-1993 (Rel. 34, Created) DT 06-FEB-2008 (Rel. 94, Last updated, Version 28) XX DE Escherichia coli integron In7 plasmid pDGO100, partial sequence. XX KW . XX OS Escherichia coli OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OG Plasmid pDGO100 XX RN [1] RP 1-2234 RX DOI; 10.1093/nar/14.21.8625 RX PUBMED; 3024112. RA Cameron F.H., Groot Obbink D.J., Ackerman V.P., Hall R.M.; RT "Nucleotide sequence of the AAD(2'') aminoglycoside adenylyltransferase RT determinant aadB. Evolutionary relationship of this region with those RT surrounding aadA in R538-1 and dhfrII in R388"; RL Nucleic Acids Res. 14(21):8625-8635(1986). XX RN [2] RX DOI; 10.1093/nar/15.18.7491 RX PUBMED; 2821509. RA Hall R.M., Vockler C.; RT "The region of the IncN plasmid R46 coding for resistance to beta-lactam RT antibiotics, streptomycin/spectinomycin and sulphonamides is closely RT related to antibiotic resistance segments found in IncW plasmids and in RT Tn21-like transposons"; RL Nucleic Acids Res. 15(18):7491-7501(1987). XX RN [3] RP 2229-3726 RX DOI; 10.1016/0147-619X(90)90047-G RX PUBMED; 2349283. RA Hall R.M., Stokes H.W.; RT "The structure of a partial duplication in the integron of plasmid RT pDGO100"; RL Plasmid 23(1):76-79(1990). XX RN [4] RP 4847-6796 RX PUBMED; 1804022. RA Parsons Y., Hall R.M., Stokes H.W.; RT "A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid RT pDGO100"; RL Antimicrob. Agents Chemother. 35(11):2436-2439(1991). XX RN [5] RP 3079-5649 RX DOI; 10.1006/plas.1993.1032 RX PUBMED; 8378445. RA Stokes H.W., Tomaras C., Parsons Y., Hall R.M.; RT "The partial 3'-conserved segment duplications in the integrons In6 from RT pSa and In7 from pDGO100 have a common origin"; RL Plasmid 30(1):39-50(1993). XX RN [6] RC plus corrections RP 6797-7634 RX DOI; 10.1128/AAC.47.1.342-349.2003 RX PUBMED; 12499211. RA Partridge S.R., Hall R.M.; RT "In34, a complex In5 family class 1 integron containing orf513 and dfrA10"; RL Antimicrob. Agents Chemother. 47(1):342-349(2003). XX RN [7] RP 1-6796 RA Stokes H.; RT ; RL Submitted (26-APR-1993) to the EMBL/GenBank/DDBJ databases. RL Department of Biological Sciences, Macquarie University, Sydney NSW, 2109, RL Australia XX RN [8] RC Sequence update by submitter RP 1-6796 RA Stokes H.; RT ; RL Submitted (07-AUG-2000) to the EMBL/GenBank/DDBJ databases. RL Department of Biological Sciences, Macquarie University, Sydney NSW, 2109, RL Australia XX RN [9] RC Sequence update by submitter RP 1-7634 RA Partridge S.R., Hall R.M.; RT ; RL Submitted (30-JUL-2001) to the EMBL/GenBank/DDBJ databases. RL CSIRO Molecular Science, PO Box 184, North Ryde, NSW 1670, Australia XX RN [10] RC Sequence update by submitter RP 1-7634 RA Partridge S.R., Hall R.M.; RT ; RL Submitted (21-NOV-2001) to the EMBL/GenBank/DDBJ databases. RL CSIRO Molecular Science, PO Box 184, North Ryde, NSW 1670, Australia XX CC On Nov 30, 2001 this sequence version replaced gi:15187303. XX FH Key Location/Qualifiers FH FT source 1..7634 FT /organism="Escherichia coli" FT /plasmid="pDGO100" FT /mol_type="genomic DNA" FT /db_xref="taxon:562" FT repeat_region 1..7634 FT /mobile_element="transposon:class 1 integron In7" FT misc_feature <1..1286 FT /note="5'-conserved segment; 5'-CS; starts at base 67 of FT standard 5'-CS" FT /citation=[2] FT gene complement(137..1150) FT /gene="intI1" FT CDS complement(137..1150) FT /codon_start=1 FT /transl_table=11 FT /gene="intI1" FT /product="IntI1 integrase" FT /note="orf3 in [2]" FT /db_xref="GOA:Q48337" FT /db_xref="HSSP:1A0P" FT /db_xref="InterPro:IPR013762" FT /db_xref="UniProtKB/TrEMBL:Q48337" FT /citation=[2] FT /protein_id="AAA92744.1" FT /translation="MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVNWVRAFI FT RFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQEI FT GRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDFDHG FT TIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALERKYPR FT AGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATPHTLRH FT SFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLTSER" FT old_sequence 294 FT /replace="cg" FT /citation=[2] FT old_sequence 745 FT /replace="ca" FT /citation=[2] FT promoter 1035..1063 FT /note="promoter Pc; transcribes cassette-associated genes; FT strong version" FT -35_signal 1035..1040 FT -10_signal 1058..1063 FT -10_signal complement(1177..1182) FT /gene="intI1" FT /citation=[2] FT -35_signal complement(1200..1205) FT /gene="intI1" FT /citation=[2] FT misc_recomb 1231..1295 FT /note="attI1; integron-associated recombination site FT recognized by IntI1" FT /experiment="experimental evidence, no additional details FT recorded" FT misc_feature 1287..1877 FT /note="aadB cassette" FT misc_recomb join(1824..1877,1287..1292) FT /note="aadB 59-be; 59-base element; IntI-type integrase FT recombination site" FT gene 1296..1829 FT /gene="aadB" FT CDS 1296..1829 FT /codon_start=1 FT /transl_table=11 FT /gene="aadB" FT /product="aminoglycoside (2'') adenylyltransferase FT AAD(2'')" FT /note="confers resistance to gentamicin, tobramycin and FT kanamycin" FT /db_xref="GOA:P0AE04" FT /db_xref="InterPro:IPR019646" FT /db_xref="UniProtKB/Swiss-Prot:P0AE04" FT /protein_id="AAA92745.1" FT /translation="MDTTQVTLIHKILAAADERNLPLWIGGGWAIDARLGRVTRKHDDI FT DLTFPGERRGELEAIVEMLGGRVMEELDYGFLAEIGDELLDCEPAWWADEAYEIAEAPQ FT GSCPEAAEGVIAGRPVRCNSWEAIIWDYFYYADEVPPVDWPTKHIESYRLACTSLGAEK FT VEVLRAAFRSRYAA" FT misc_feature 1878..3190 FT /note="first copy of 3'-conserved segment; consists of FT bases 1-1313 of standard 3'-CS" FT /citation=[3] FT -35_signal 1928..1933 FT -10_signal 1952..1957 FT RBS 1975..1978 FT /gene="qacEdelta1" FT gene 1986..2333 FT /gene="qacEdelta1" FT CDS 1986..2333 FT /codon_start=1 FT /transl_table=11 FT /gene="qacEdelta1" FT /product="QacEdelta1" FT /note="previously orf4" FT /db_xref="GOA:Q48338" FT /db_xref="HSSP:1S7B" FT /db_xref="InterPro:IPR000390" FT /db_xref="UniProtKB/TrEMBL:Q48338" FT /protein_id="AAA92746.2" FT /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFY FT FLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSP FT SWKSLRRPTPW" FT old_sequence 2067 FT /replace="g" FT /citation=[6] FT old_sequence 2109 FT /replace="ga" FT /citation=[2] FT RBS 2314..2318 FT /gene="sul1" FT gene 2327..3166 FT /gene="sul1" FT CDS 2327..3166 FT /codon_start=1 FT /transl_table=11 FT /gene="sul1" FT /product="dihydropteroate synthase" FT /note="confers resistance to sulphonamides" FT /db_xref="GOA:P0C002" FT /db_xref="HSSP:1EYE" FT /db_xref="InterPro:IPR006390" FT /db_xref="UniProtKB/Swiss-Prot:P0C002" FT /protein_id="AAA92747.1" FT /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVG FT PAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQ FT GFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRS FT GVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLP FT VKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA" FT misc_feature 3191..5344 FT /note="common region; also found in In6 from pSa" FT old_sequence 3214 FT /replace="tt" FT /citation=[5] FT old_sequence 3236 FT /replace="a" FT /citation=[5] FT old_sequence 3264..3265 FT /replace="g" FT /citation=[5] FT old_sequence 3340..3385 FT /replace="cc" FT /citation=[8] FT -35_signal 3366..3371 FT /gene="orf513" FT -10_signal 3388..3393 FT /gene="orf513" FT old_sequence 3558..3559 FT /replace="g" FT /citation=[8] FT RBS 3560..3564 FT /gene="orf513" FT gene 3571..5112 FT /gene="orf513" FT CDS 3571..5112 FT /codon_start=1 FT /transl_table=11 FT /gene="orf513" FT /product="Orf513" FT /note="unknown function" FT /db_xref="GOA:Q932Q4" FT /db_xref="InterPro:IPR007069" FT /db_xref="UniProtKB/TrEMBL:Q932Q4" FT /protein_id="AAA92748.2" FT /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASLE FT AQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGARRM FT AESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIKKAG FT YTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYDELNT FT LAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGPQQGRK FT VFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPAVSEKRL FT ALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVFAPNSKHR FT VQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVCEHCGGHVK FT VIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQSRLFD" FT old_sequence 3588..3589 FT /replace="g" FT /citation=[5] FT old_sequence 3722 FT /replace="a" FT /citation=[5] FT old_sequence 4529..4531 FT /replace="gg" FT /citation=[6] FT old_sequence 4790..4793 FT /replace="gg" FT /citation=[6] FT old_sequence 4865..4866 FT /replace="c" FT /citation=[6] FT old_sequence 4971..4972 FT /replace="g" FT /citation=[5] FT -35_signal 5445..5450 FT /gene="dfrA10" FT -10_signal 5468..5473 FT /gene="dfrA10" FT RBS 5483..5485 FT /gene="dfrA10" FT gene 5494..6057 FT /gene="dfrA10" FT CDS 5494..6057 FT /codon_start=1 FT /transl_table=11 FT /gene="dfrA10" FT /product="dihydrofolate reductase" FT /note="confers resistance to trimethoprim; previously FT dhfrX" FT /db_xref="GOA:Q04515" FT /db_xref="HSSP:1DYR" FT /db_xref="InterPro:IPR017925" FT /db_xref="UniProtKB/Swiss-Prot:Q04515" FT /protein_id="AAA92749.1" FT /translation="MNISLIFANELITRAFGNQGKLPWQFIKEDMQFFQKTTENSVVVM FT GLNTWRSLPKMKKLGRDFIVISSTITEHEVLNNNIQIFKSFESFLEAFRDTTKPINVIG FT GVGLLSEAIEHASTVYMSSIHMVKPVHADVYVPVELMNKLYSDFKYPENILWVGDPIDS FT VYSLSIDKFVRPASLVGVPNDINT" FT misc_feature 6062..>7634 FT /note="'second copy of 3'-CS; starts at base 77 of standard FT 3'-CS'" FT RBS 6083..6086 FT /gene="qacEdelta1" FT gene 6094..6441 FT /gene="qacEdelta1" FT CDS 6094..6441 FT /codon_start=1 FT /transl_table=11 FT /gene="qacEdelta1" FT /product="QacEdelta1" FT /note="previously orf4" FT /db_xref="GOA:Q48338" FT /db_xref="HSSP:1S7B" FT /db_xref="InterPro:IPR000390" FT /db_xref="UniProtKB/TrEMBL:Q48338" FT /protein_id="AAA92750.1" FT /translation="MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFY FT FLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSP FT SWKSLRRPTPW" FT RBS 6422..6426 FT /gene="sul1" FT gene 6435..7274 FT /gene="sul1" FT CDS 6435..7274 FT /codon_start=1 FT /transl_table=11 FT /gene="sul1" FT /product="dihydropteroate synthase" FT /db_xref="GOA:P0C002" FT /db_xref="HSSP:1EYE" FT /db_xref="InterPro:IPR006390" FT /db_xref="UniProtKB/Swiss-Prot:P0C002" FT /protein_id="AAA92751.3" FT /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVG FT PAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQ FT GFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRS FT GVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLP FT VKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA" FT gene 7402..>7634 FT /gene="orf5" FT CDS 7402..>7634 FT /codon_start=1 FT /transl_table=11 FT /gene="orf5" FT /product="unknown" FT /db_xref="UniProtKB/TrEMBL:Q79EC3" FT /protein_id="AAK91386.1" FT /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARID FT RTFAETFVLRSELLVASCSDGIVGCCTLSAEDP" XX SQ Sequence 7634 BP; 1728 A; 2095 C; 2109 G; 1702 T; 0 other; ggatccatca ggcaacgacg ggctgctgcc ggccatcagc ggacgcaggg aggactttcc 60 gcaaccggcc gttcgatgcg gcaccgatgg ccttcgcgca ggggtagtga atccgccagg 120 attgacttgc gctgccctac ctctcactag tgaggggcgg cagcgcatca agcggtgagc 180 gcactccggc accgccaact ttcagcacat gcgtgtaaat catcgtcgta gagacgtcgg 240 aatggccgag cagatcctgc acggttcgaa tgtcgtaacc gctgcggagc aaggccgtcg 300 cgaacgagtg gcggagggtg tgcggtgtgg cgggcttcgt gatgcctgct tgttctacgg 360 cacgtttgaa ggcgcgctga aaggtctggt catacatgtg atggcgacgc acgacaccgc 420 tccgtggatc ggtcgaatgc gtgtgctgcg caaaaaccca gaaccacggc caggaatgcc 480 cggcgcgcgg atacttccgc tcaagggcgt cgggaagcgc aacgccgctg cggccctcgg 540 cctggtcctt cagccaccat gcccgtgcac gcgacagctg ctcgcgcagg ctgggtgcca 600 agctctcggg taacatcaag gcccgatcct tggagccctt gccctcccgc acgatgatcg 660 tgccgtgatc gaaatccaga tccttgaccc gcagttgcaa accctcactg atccgcatgc 720 ccgttccata cagaagctgg gcgaacaaac gatgctcgcc ttccagaaaa ccgaggatgc 780 gaaccacttc atccggggtc agcaccaccg gcaagcgccg cgacggccga ggtcttccga 840 tctcctgaag ccagggcaga tccgtgcaca gcaccttgcc gtagaagaac agcaaggccg 900 ccaatgcctg acgatgcgtg gagaccgaaa ccttgcgctc gttcgccagc caggacagaa 960 atgcctcgac ttcgctgctg cccaaggttg ccgggtgacg cacaccgtgg aaacggatga 1020 aggcacgaac ccagttgaca taagcctgtt cggttcgtaa actgtaatgc aagtagcgta 1080 tgcgctcacg caactggtcc agaaccttga ccgaacgcag cggtggtaac ggcgcagtgg 1140 cggttttcat ggcttgttat gactgttttt ttgtacagtc tatgcctcgg gcatccaagc 1200 agcaagcgcg ttacgccgtg ggtcgatgtt tgatgttatg gagcagcaac gatgttacgc 1260 agcagggcag tcgccctaaa acaaagttag gccgcatgga cacaacgcag gtcacattga 1320 tacacaaaat tctagctgcg gcagatgagc gaaatctgcc gctctggatc ggtgggggct 1380 gggcgatcga tgcacggcta gggcgtgtaa cacgcaagca cgatgatatt gatctgacgt 1440 ttcccggcga gaggcgcggc gagctcgagg caatagttga aatgctcggc gggcgcgtca 1500 tggaggagtt ggactatgga ttcttagcgg agatcgggga tgagttactt gactgcgaac 1560 ctgcttggtg ggcagacgaa gcgtatgaaa tcgcggaggc tccgcagggc tcgtgcccag 1620 aggcggctga gggcgtcatc gccgggcggc cagtccgttg taacagctgg gaggcgatca 1680 tctgggatta cttttactat gccgatgaag taccaccagt ggactggcct acaaagcaca 1740 tagagtccta caggctcgca tgcacctcac tcggggcgga aaaggttgag gtcttgcgtg 1800 ccgctttcag gtcgcgatat gcggcctaac aattcgtcca agccgacgcc gcttcgcggc 1860 gcggcttaac tcaggtgtta gatgcactaa gcacataatt gctcacagcc aaactatcag 1920 gtcaagtctg cttttattat ttttaagcgt gcataataag ccctacacaa attgggagat 1980 atatcatgaa aggctggctt tttcttgtta tcgcaatagt tggcgaagta atcgcaacat 2040 ccgcattaaa atctagcgag ggctttacta agcttgcccc ttccgccgtt gtcataatcg 2100 gttatggcat cgcattttat tttctttctc tggttctgaa atccatccct gtcggtgttg 2160 cttatgcagt ctggtcggga ctcggcgtcg tcataattac agccattgcc tggttgcttc 2220 atgggcaaaa gcttgatgcg tggggctttg taggtatggg gctcataatt gctgcctttt 2280 tgctcgcccg atccccatcg tggaagtcgc tgcggaggcc gacgccatgg tgacggtgtt 2340 cggcattctg aatctcaccg aggactcctt cttcgatgag agccggcggc tagaccccgc 2400 cggcgctgtc accgcggcga tcgaaatgct gcgagtcgga tcagacgtcg tggatgtcgg 2460 accggccgcc agccatccgg acgcgaggcc tgtatcgccg gccgatgaga tcagacgtat 2520 tgcgccgctc ttagacgccc tgtccgatca gatgcaccgt gtttcaatcg acagcttcca 2580 accggaaacc cagcgctatg cgctcaagcg cggcgtgggc tacctgaacg atatccaagg 2640 atttcctgac cctgcgctct atcccgatat tgctgaggcg gactgcaggc tggtggttat 2700 gcactcagcg cagcgggatg gcatcgccac ccgcaccggt caccttcgac ccgaagacgc 2760 gctcgacgag attgtgcggt tcttcgaggc gcgggtttcc gccttgcgac ggagcggggt 2820 cgctgccgac cggctcatcc tcgatccggg gatgggattt ttcttgagcc ccgcaccgga 2880 aacatcgctg cacgtgctgt cgaaccttca aaagctgaag tcggcgttgg ggcttccgct 2940 attggtctcg gtgtcgcgga aatccttctt gggcgccacc gttggccttc ctgtaaagga 3000 tctgggtcca gcgagccttg cggcggaact tcacgcgatc ggcaatggcg ctgactacgt 3060 ccgcacccac gcgcctggag atctgcgaag cgcaatcacc ttctcggaaa ccctcgcgaa 3120 atttcgcagt cgcgacgcca gagaccgagg gttagatcat gcctagcatt caccttccgg 3180 ccgcccgcta aatatctcct tttgggttgt taataaaaca tccaataagt tgactgtgcg 3240 tgaaaaagaa agttttgtgt gatggcgttg aagatcgcac cgttaagctc ttatgtggga 3300 tggtgcagag ctcgacgact accgataaaa cgcaaccgcc gcaaacagac aagaaaaagc 3360 cccaactgat aacagttggg gcttcagtat tgtgattggt ggagcaatag caccctgaac 3420 ccaaaacctt ctcgctcaac cggtagtggc tgataacaac tcgtgagggc tattgcgggt 3480 taagcattta gcgatgtcta gggccagact ggacgtctga acgcaagccg ctgatactgt 3540 acataaccac agtatcagcg gaggataccc atgtcgctgg caaggaacgc cacggcgagt 3600 caatcgccca ctcaaacaaa cggttacgaa cgccaccaac ccgaccagac gctgctctac 3660 cagctggttg agcagcacta cccagccttc aaagcctcac tcgaagccca aggtcaacac 3720 ctgcctcgct acatccaaca agaattcaac gacctcctcc aatgtggccg tctggagtat 3780 ggtttcatgc gggttcgctg cgaggattgt catcacgagc gtctggtcgc cttcagctgt 3840 aaacgacgcg gcttttgccc tagctgcggt gcccgccgga tggccgagag tgcggcgctg 3900 ctgatagacg aagtcttccc caaggagccc attcgccagt gggtgctcag ctttcctttc 3960 cagctacgct ttttgctggc tcgccatccc cagctgatgg gccaggtctt gagtatcgtc 4020 tatcgtacac tctcaactca tctgatcaaa aaagccggtt acaccaaagc ctctgcacaa 4080 actggctcag tgactcttat ccaacgcttt ggctccgcgc taaatctcaa tgtccactac 4140 cacatgctgt ttctcgatgg tgtctatgcc gaagatgact atggcaagca acgcttccat 4200 cgtgtcaagg cacccactta cgatgagctg aatacgctcg ctcacaccct cagccatcgc 4260 atcgctcgct gcatggaaaa gcgtgggatt ttggagcgtg atgccgagaa tacgtggttg 4320 acactggaag agggcgaaga cgatacgctg actcaattac atggtgcttc ggttacgtat 4380 cgcattgccg tcggccccca gcaagggcgc aaagtcttca ccctgcaaac cttgccaggg 4440 cgtgaggata aagccgactc aagcagtcga gtagccaacc atgctggttt ctcgctacac 4500 gccggtgtga tggccgaagc gcatcagcgg gataagcttg agcgcttgtg tcgctacatt 4560 agtcggccag cggtttcaga aaaacgtctg gcattaaccg ccaatgggca ggtgcgttac 4620 gagctcaaaa ctccgtaccg caatggcacc acccatgtga tcttcgagcc gctggacttc 4680 atcgccaaac tcgctgcgtt ggtacctaag ccgcgagtca acctcacacg cttccacggc 4740 gtctttgcac cgaacagcaa acaccgagtt caagtaacac ccgccaagcg gggcaagaag 4800 cccgacaaat cggaaggtct cgatactaac tggcgtgaca agagtcctgc agagcgccac 4860 cgcgccatga cctggatgca acgcctcaag cgagtcttca atattgatat tgaagtctgc 4920 gaacactgcg gcggtcacgt caaagtgatt gccagcatcg aagatccgaa ggtcattgag 4980 cagattctca agcatctgaa acagaaaaca gccaaggcga atgccgccaa gcagcgtgag 5040 ctgccaccag aacgagcgcc gccactgact cccagcctgt tcgatccatc acagagtcgt 5100 ctctttgact gacgacccca aatccaacac tgctcaacac tgccaacttt taaacggggc 5160 ggtggggcag tttgtatctc tcgagctatc aggctagaga ttttaccgcc aaatcgaacc 5220 ttattagagc ggtttaggct ggaccggcag ttaaaattgg ggcttgagcg gtaaacgagt 5280 gagggaattt caggtaagat acttcggatg aggagcaaaa aggtggttta tacttcctat 5340 acccgtaact gcttacagtg agtttgaaga aaccagagca aactacaaaa gtgaaggtga 5400 atgtatcaag aaactaatag ctcaaggtcg tgagcgtatt gatattggaa ccagtaatgg 5460 tacttgttat tacattccta atggatacta caaatgaata tatcacttat ctttgccaat 5520 gaattaatta ccagagcatt cggtaatcaa ggcaaattac cttggcaatt cattaaagaa 5580 gatatgcagt tcttccagaa gactacagaa aattctgtag tcgttatggg attaaataca 5640 tggagatctc tacctaagat gaagaagctt ggtagagact tcattgtcat atcttcaact 5700 atcacagagc acgaagtgct caacaataat atccaaatat tcaaatcatt tgagagcttc 5760 ttagaagcat tcagagacac aaccaaacca atcaatgtca ttggtggtgt tggtttatta 5820 tctgaagcga tagaacatgc tagcactgtt tacatgagtt ctattcatat ggttaaacct 5880 gttcatgctg atgtgtatgt accggtagaa ctaatgaata aactctatag tgatttcaaa 5940 tatccagaaa atattctatg ggtaggtgat ccaatagatt ctgtgtatag cttgtctatt 6000 gataagtttg ttagaccagc ttcgctggtt ggggtgccaa atgatattaa tacgtgatta 6060 ctaataagcc ctacacaaat tgggagatat atcatgaaag gctggctttt tcttgttatc 6120 gcaatagttg gcgaagtaat cgcaacatcc gcattaaaat ctagcgaggg ctttactaag 6180 cttgcccctt ccgccgttgt cataatcggt tatggcatcg cattttattt tctttctctg 6240 gttctgaaat ccatccctgt cggtgttgct tatgcagtct ggtcgggact cggcgtcgtc 6300 ataattacag ccattgcctg gttgcttcat gggcaaaagc ttgatgcgtg gggctttgta 6360 ggtatggggc tcataattgc tgcctttttg ctcgcccgat ccccatcgtg gaagtcgctg 6420 cggaggccga cgccatggtg acggtgttcg gcattctgaa tctcaccgag gactccttct 6480 tcgatgagag ccggcggcta gaccccgccg gcgctgtcac cgcggcgatc gaaatgctgc 6540 gagtcggatc agacgtcgtg gatgtcggac cggccgccag ccatccggac gcgaggcctg 6600 tatcgccggc cgatgagatc agacgtattg cgccgctctt agacgccctg tccgatcaga 6660 tgcaccgtgt ttcaatcgac agcttccaac cggaaaccca gcgctatgcg ctcaagcgcg 6720 gcgtgggcta cctgaacgat atccaaggat ttcctgaccc tgcgctctat cccgatattg 6780 ctgaggcgga ctgcaggctg gtggttatgc actcagcgca gcgggatggc atcgccaccc 6840 gcaccggtca ccttcgaccc gaagacgcgc tcgacgagat tgtgcggttc ttcgaggcgc 6900 gggtttccgc cttgcgacgg agcggggtcg ctgccgaccg gctcatcctc gatccgggga 6960 tgggattttt cttgagcccc gcaccggaaa catcgctgca cgtgctgtcg aaccttcaaa 7020 agctgaagtc ggcgttgggg cttccgctat tggtctcggt gtcgcggaaa tccttcttgg 7080 gcgccaccgt tggccttcct gtaaaggatc tgggtccagc gagccttgcg gcggaacttc 7140 acgcgatcgg caatggcgct gactacgtcc gcacccacgc gcctggagat ctgcgaagcg 7200 caatcacctt ctcggaaacc ctcgcgaaat ttcgcagtcg cgacgccaga gaccgagggt 7260 tagatcatgc ctagcattca ccttccggcc gcccgctagc ggaccctggt caggttccgc 7320 gaaggtgggc gcagacatgc tgggctcgtc aggatcaaac tgcactatga ggcggcggtt 7380 cataccgcgc caggggagcg aatggacagc gaggagcctc cgaacgttcg ggtcgcctgc 7440 tcgggtgata tcgacgaggt tgtgcggctg atgcacgacg ctgcggcgtg gatgtccgcc 7500 aagggaacgc ccgcctggga cgtcgcgcgg atcgaccgga cattcgcgga gaccttcgtc 7560 ctgagatccg agctcctagt cgcgagttgc agcgacggca tcgtcggctg ttgcaccttg 7620 tcggccgagg atcc 7634 // |
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