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EBI DbfetchID K02120; SV 1; linear; genomic RNA; STD; VRL; 8714 BP. XX AC K02120; XX DT 13-JUN-1985 (Rel. 06, Created) DT 03-AUG-2006 (Rel. 88, Last updated, Version 5) XX DE Bovine leukemia virus complete genome. XX KW complete genome; endonuclease; env protein; gag protein; pol protein; KW proviral gene; reverse transcriptase; surface glycoprotein; KW transmembrane protein. XX OS Bovine leukemia virus OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Deltaretrovirus. XX RN [1] RP 1-8714 RX DOI; 10.1073/pnas.82.3.677 RX PUBMED; 2983308. RA Sagata N., Yasunaga T., Tsuzuku-Kawamura J., Ohishi K., Ogawa Y., Ikawa Y.; RT "Complete nucleotide sequence of the genome of bovine leukemia virus: its RT evolutionary relationship to other retroviruses"; RL Proc. Natl. Acad. Sci. U.S.A. 82(3):677-681(1985). XX DR EPD; EP16079; BLV_LTR. DR RFAM; RF00192; BLV_package. DR UniProtKB/Swiss-Prot; P03412; YPX1_BLVJ. DR UniProtKB/Swiss-Prot; P03413; YPX2_BLVJ. DR UniProtKB/Swiss-Prot; P03414; YPX3_BLVJ. XX CC The organization of the BLV genome is as follows: 5' LTR - gag - CC pol - env - pX-BL - 3' LTR, where pX-BL is a region containing CC several open reading frames. CC [1] suggests, based on the pattern of conservation in the pol CC region, that BLV and human T-cell leukemia virus (HTLV) constitute CC a separate group, designated type E, of Oncovirinae. The initiation CC of translation of the pol reading frame is undetermined. A CC potential splice acceptor (at 4391-4401) for the env mRNA is CC identified by similarity to the consensus sequence. XX FH Key Location/Qualifiers FH FT source 1..8714 FT /organism="Bovine leukemia virus" FT /mol_type="genomic RNA" FT /db_xref="taxon:11901" FT LTR 1..530 FT /standard_name="5' LTR" FT gene 628..1806 FT /gene="gag" FT CDS 628..1806 FT /codon_start=1 FT /gene="gag" FT /standard_name="gag-Pr45" FT /product="gag" FT /db_xref="GOA:P03344" FT /db_xref="InterPro:IPR000721" FT /db_xref="InterPro:IPR001878" FT /db_xref="InterPro:IPR003139" FT /db_xref="InterPro:IPR008916" FT /db_xref="InterPro:IPR008919" FT /db_xref="InterPro:IPR010999" FT /db_xref="InterPro:IPR013084" FT /db_xref="UniProtKB/Swiss-Prot:P03344" FT /protein_id="AAA42784.1" FT /translation="MGNSPSYNPPAGISPSDWLNLLQSAQRLNPRPSPSDFTDLKNYIH FT WFHKTQKKPWTFTSGGPTSCPPGRFGRVPLVLATLNEVLSNEGGAPGASAPEEQPPPYD FT PPAILPIISEGNRNRHRAWALRELQDIKKEIENKAPGSQVWIQTLRLAILQADPTPADL FT EQLCQYIASPVDQTAHMTSLTAAIAAAEAATPSRVLTPKTGTLTQQSAQPNAGDLRSQY FT QNLWLQAGKISLLVLQLQPWSTIVQGPAESSVEFVNRLQISLADNLPDGVLRNPLLTPL FT VMQMLTESVSKFCRGEASGRGGAKTAGLRTIGPPRMKQPALLVHTPGPKMPGPRQPAPK FT RPPPGPCYRCLKEGHWARDCPTKATGPPPGPCPICKDPSHWKRDCPTLKSKN" FT mat_peptide 628..954 FT /gene="gag" FT /product="gag-p15 polyprotein" FT mat_peptide 955..1545 FT /gene="gag" FT /product="gag-p24 polyprotein" FT mat_peptide 1597..1803 FT /gene="gag" FT /product="gag-12 polyprotein" FT gene <2467..4875 FT /gene="pol" FT CDS <2467..4875 FT /codon_start=1 FT /gene="pol" FT /product="pol protein" FT /db_xref="GOA:P03361" FT /db_xref="InterPro:IPR000477" FT /db_xref="InterPro:IPR001037" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR002156" FT /db_xref="InterPro:IPR012337" FT /db_xref="UniProtKB/Swiss-Prot:P03361" FT /protein_id="AAA42785.1" FT /translation="VHDLRATNALTKPIPALSPGPPDLTAIPTHPPHIICLDLKDAFFQ FT IPVEDRFRFYLSFTLPSPGGLQPHRRFAWRVLPQGFINSPALFERALQEPLRQVSAAFS FT QSLLVSYMDDILYASPTEEQRSQCYQALAARLRDLGFQVASEKTSQTPSPVPFLGQMVH FT EQIVTYQSLPTLQISSPISLHQLQAVLGDLQWVSRGTPTTRRPLQLLYSSLKRHHDPRA FT IIQLSPEQLQGIAELRQALSHNARSRYNEQEPLLAYVHLTRAGSTLVLFQKGAQFPLAY FT FQTPLTDNQASPWGLLLLLGCQYLQTQALSSYAKPILKYYHNLPKTSLDNWIQSSEDPR FT VQELLQLWPQISSQGIQPPGPWKTLITRAEVFLTPQFSPDPIPAALCLFSDGATGRGAY FT CLWKDHLLDFQAVPAPESAQKGELAGLLAGLAAAPPEPVNIWVDSKYLYSLLRTLVLGA FT WLQPDPVPSYALLYKSLLRHPAIVVGHVRSHSSASHPIASLNNYVDQLLPLETPEQWHK FT LTHCNSRALSRWPNPRISAWDPRSPATLCETCQKLNPTGGGKMRTIQRGWAPNHIWQAD FT ITHYKYKQFTYALHVFVDTYSGATHASAKRGLTTQTTIEGLLEAIVHLGRPKKLNTDQG FT ANYTSKTFVRFCQQFGVSLSHHVPYNPTSSGLDERTNGLLKLLLSKYHLDEPHLPMTQA FT LSRALWTHNQINLLPILKTRWELHHSPPLAVISEGGETPKGSDKLFLYLLPGQNNRRWL FT GPLPALVEASGGALLATDPPVWVPWRLLKAFKCLKNDGPEDAHNRSSDG" FT gene 4821..6368 FT /gene="env" FT CDS 4821..6368 FT /codon_start=1 FT /gene="env" FT /product="envelope polyprotein" FT /db_xref="GOA:P03380" FT /db_xref="InterPro:IPR002050" FT /db_xref="InterPro:IPR018154" FT /db_xref="UniProtKB/Swiss-Prot:P03380" FT /protein_id="AAA42786.1" FT /translation="MPKERRSRRRPQPIIRWVSLTLTLLALCRPIQTWRCSLSLGNQQW FT MTAYNQEAKFSISIDQILEAHNQSPFCAKSPRYTLDSVNGYPKIYWPPPQGRRRFGARA FT MVTYDCEPRCPYVGADRFDCPHWDNASQADQGSFYVNHQILFLHLKQCHGIFTLTWEIW FT GYDPLITFSLHKIPDPPQPDFPQLNSDWVPSVRSWALLLNQTARAFPDCAICWEPSPPW FT APEILVYNKTISSSGPGLALPDAQIFWVNSSSFNTTQGWHHPSQRLLFNVSQGNALLLP FT PISLVNLSTASSAPPTRVRRSPVAALTLGLALSVGLTGINVAVSALSHQRLTSLIHVLE FT QDQQRLITAINQTHYNLLNVASVVAQNRRGLDWLYIRLGFQSLCPTINEPCCFLRIQND FT SIILRGDLQPLSQRVSTDWQWPWNWDLGLTAWVRETIHSVLSLFLLALFLLFLAPCLIK FT CLTSRLLKLLRQAPHFPEISLTPKPDSDYQALLPSAPEIYSHLSPVKPDYINLRPCP" FT sig_peptide 4821..4919 FT /gene="env" FT mat_peptide 4920..5723 FT /gene="env" FT /product="gp51 surface glycoprotein (env)" FT mat_peptide 5724..6365 FT /gene="env" FT /product="gp30 transmembrane protein (env)" FT LTR 8185..8714 FT /standard_name="3' LTR" XX SQ Sequence 8714 BP; 1898 A; 2879 C; 1864 G; 2073 T; 0 other; tgtatgaaag atcatgccga cctaggagcc gccaccgccc cgtaaaccag acagagacgt 60 cagctgccag aaaagctggt gacggcagct ggtggctaga atccccgtac ctccccaact 120 tcccctttcc cgaaaaatcc acaccctgag ctgctgacct cacctgctga taaattaata 180 aaatgccggc cctgtcgagt tagcggcacc agaagcgttc ttctcctgag accctcgtgc 240 tcagctctcg gtcctgagct ctcttgctcc cgagaccttc tggtcggcta tccggcagcg 300 gtcaggtaag gcaagcacgg tttggagggt ggttctcggc tgagaccacc gcgagctcta 360 tctccggtcc tctgaccgtc tccacgtgga ctctctcctt tgcctcctga ccccgcgctc 420 caagggcgtc tggcttgcac ccgcgtttgt ttcctgtctt actttctgtt tctcgcggcc 480 cgcgctctct ccttcggcgc cctctagcgg ccaggagaga ccggcaaaca attgggggct 540 cgtccgggat tgatcacccc ggaaccctaa caactctctg gacccacccc ctcggcggca 600 ttttgggtct ctccttcaaa ttatatcatg ggaaattccc cctcctataa cccccccgct 660 ggtatctccc cctcagactg gctcaacctt ctgcaaagcg cgcaaaggct caatccgcga 720 ccctctccta gcgattttac cgatttaaag aattacatcc attggtttca taagacccag 780 aaaaaaccat ggactttcac ttctggtggc cccacctcat gtccacccgg gagattcggc 840 cgggttcccc tcgtcttggc caccctaaac gaagtactct caaacgaagg gggcgccccg 900 ggtgcatcgg ccccagaaga acaacccccc ccttatgacc cccccgccat tttgccaatc 960 atatctgaag ggaatcgcaa ccgccatcgt gcttgggcac tccgagaatt acaagatatc 1020 aaaaaagaaa ttgaaaataa ggcaccgggt tcgcaagtat ggatacaaac actacgactt 1080 gcaatcctgc aggccgaccc tactccggct gacctagaac aactttgcca atatattgct 1140 tccccggtcg accaaacggc ccatatgacc agcctaacgg cagcaatagc cgccgctgaa 1200 gcggcaacac cctccagggt tttaaccccc aaaacgggta ccctaaccca acaatcagct 1260 cagcccaacg ccggggatct tagaagtcaa tatcaaaacc tctggcttca ggccggaaaa 1320 atctccctac tcgtccttca gctacaacct tggtccacca tcgtccaagg ccccgccgaa 1380 agctctgtag agtttgtcaa ccggttacaa atttcattag ctgacaacct tcccgacgga 1440 gtcctaagga acccattatt gactccctta gttatgcaaa tgctaacaga gagtgtcagc 1500 aaattttgca ggggcgaggc cagtggccgc ggtggggcaa aaactgcagg cttgcgcaca 1560 attgggcccc caagaatgaa acagcctgca cttctcgtcc acaccccagg gcccaagatg 1620 cccgggcctc ggcaaccggc ccccaaaagg cctcccccag gaccatgcta tcgatgcctc 1680 aaagaaggcc attgggcccg ggattgtcct accaaggcca ccggcccacc tccgggacct 1740 tgccccatat gtaaagatcc ttcccattgg aaacgagact gtccaaccct caaatcaaaa 1800 aactaataga ggggggactt agcgcccccc aaaccataac acctataacg gattctctta 1860 gtgaggccga attagaatgc ttactttcta ttcctctggc tcgcagccgt ccctccgtgg 1920 ctgtatacct gtctggcccc tggctgcagc cctctcagaa tcaagccctc atgcttgtgg 1980 acaccggggc tgaaaatacg gttctcccac aaaattggct ggttcgagat tacccacgga 2040 tccccgccgc agtgctcgga gcagggggag tctcccggaa cagatacaat tggctacaag 2100 gccctctgac cctggctcta aaaccagagg gtccctttat caccatccca aaaattttag 2160 ttgacacttc cgacaaatgg caaattttag gacgggacgt ccctcccgcc tacaggcttc 2220 tatctccata cctgaggaag tacgcccccc tgtggtaggc gtcttggata cccccccgag 2280 ccacattgga ttagaacatc tgcccccccc acctgaggtg cctcaattcc ctttaaacta 2340 gaacgcctcc aggcccttca agacctggtc catcgctctc tggaggcagg ttatatctcc 2400 ccctgggacg ggccaggcaa taatccagtc ttcccggtac ggaaaccaaa tggcgcctgg 2460 aggtttgtgc atgacctacg agctacaaat gctcttacaa agcccattcc ggcactctct 2520 cccggaccgc cagaccttac cgctatccct acgcaccctc cacatatcat ttgcctagat 2580 ctcaaagatg ccttcttcca gattccagtc gaagaccgct tccgcttcta cttgtctttt 2640 accctcccat cccccggggg actccaacct catagacgct ttgcctggcg ggtcctacct 2700 caaggcttca ttaacagccc agctcttttc gaacgagcac tacaggaacc tcttcgccaa 2760 gtttccgccg ccttttccca gtctcttctg gtgtcctata tggacgatat cctttacgct 2820 tcgcctacag aagaacagcg gtcacaatgt tatcaagccc tggctgcccg cctccgggac 2880 ctagggtttc aggtggcatc cgaaaagact agccagacgc cttcgcccgt cccctttttg 2940 ggacaaatgg tccatgagca gattgtcacc taccagtccc tacctacctt gcagatctca 3000 tccccaattt ctcttcacca attacaggcg gtcttaggag acctccaatg ggtctctagg 3060 ggcacaccca ctacccgccg gcccctgcaa cttctctact cttcccttaa aaggcatcat 3120 gaccctaggg ccatcatcca gctttccccg gaacagctgc aaggcattgc agagcttcga 3180 caagccctgt cccacaacgc aagatctaga tataacgagc aagaacccct gctagcctac 3240 gtacacctaa cccgggcggg gtccaccctg gtactcttcc aaaagggcgc tcaatttccc 3300 ctggcctact ttcagacccc cttgactgac aaccaagcct caccttgggg cctccttctc 3360 ctgctgggat gccaatacct gcagactcag gccttaagct cgtatgccaa gcccatactt 3420 aaatattatc acaatcttcc taaaacctct ctagacaatt ggattcaatc atctgaggac 3480 cctcgagtcc aggagttgct gcaattgtgg ccccagattt cctctcaggg aatacagccc 3540 ccgggccctt ggaagacctt aatcaccagg gcagaggttt ttttgacgcc ccagttctcc 3600 cctgatccga ttcctgcggc cctttgcctc tttagtgacg gggctacagg acgaggagca 3660 tattgcttgt ggaaagacca ccttttagac tttcaggccg ttccggcccc agaatccgct 3720 caaaagggag aactagcagg tctcttggcg ggcttagcag ccgccccgcc tgaacctgta 3780 aatatatggg tagattccaa atacctgtac tctttgctca gaaccctagt tctgggagct 3840 tggcttcaac ctgaccccgt accctcctac gccctcctat ataaaagcct cctccgacat 3900 ccagcaatcg ttgttggtca tgtccggagc cactcttcag catcccaccc tattgcttcc 3960 ctgaacaatt atgtagatca actgcttccc ttagaaactc cagagcaatg gcataagctc 4020 acccactgca actctcgggc cttgtctcga tggccgaacc cacgtatctc tgcctgggac 4080 ccccgttccc ccgctacgct gtgtgaaacc tgccaaaagc ttaatccaac tggaggagga 4140 aagatgcgaa ctattcagag agggtgggcc ccgaatcata tttggcaggc cgatataacc 4200 cattataaat acaaacagtt cacctacgct ctgcatgtgt ttgtagatac ttactctgga 4260 gctactcatg cctcggcgaa gcgtgggctc accactcaaa cgaccattga gggccttctt 4320 gaggccatag tgcatctggg tcgcccaaaa aagctaaaca ctgaccaagg tgcaaactac 4380 acctccaaaa cctttgtcag gttttgccag cagttcggag tttccctttc tcatcatgtt 4440 ccctacaacc ccacaagttc ggggttagat gaacggacaa atggactgct caaacttctt 4500 ctatctaaat atcacctaga cgaaccccac cttcccatga ctcaggccct ttctcgagcc 4560 ctctggactc acaatcagat taacctccta ccaattctaa agaccagatg ggagctacac 4620 cattcacccc cacttgctgt catttcagag ggcggagaaa cacccaaggg ctctgataaa 4680 ctctttttgt acttgctccc cgggcaaaac aatcgtcggt ggctaggacc actcccggcc 4740 ctagtcgaag cctcgggagg cgctctcctg gctactgacc cccccgtgtg ggttccctgg 4800 cgtttgctga aagccttcaa atgcctaaag aacgacggtc ccgaagacgc ccacaaccga 4860 tcatcagatg ggtaagtctc actctcactc tcctcgctct ctgtcggccc atccagactt 4920 ggagatgctc cctgtcccta ggaaaccaac aatggatgac agcatataac caagaggcaa 4980 aattttccat ctccattgac caaatactag aggctcataa tcagtcacct ttctgtgcca 5040 agtctcccag atacaccttg gactctgtaa atggctatcc taagatctac tggccccccc 5100 cacaagggcg gcgccggttt ggagccaggg ccatggtcac atatgattgc gagccccgat 5160 gcccttatgt gggggcagat cggttcgact gcccccactg ggacaatgcc tcccaggctg 5220 atcaaggatc cttttatgtc aatcatcaga ttttattcct gcatctcaaa caatgtcatg 5280 gaattttcac tctaacctgg gagatatggg gatatgatcc cctgatcacc ttttctttac 5340 ataagatccc tgatccccct caacccgact ttccccagtt gaacagtgac tgggttccct 5400 ctgtcagatc atgggccctg cttttaaatc aaacagcacg ggccttccca gactgtgcta 5460 tatgttggga accttcccct ccctgggctc ccgaaatatt agtatataac aaaaccatct 5520 ccagctctgg acccggcctc gccctcccgg acgcccaaat cttctgggtc aactcgtcct 5580 cgtttaacac cacccaagga tggcaccacc cttcccagag gttgttgttc aatgtttctc 5640 aaggcaacgc cttgttatta cctcctatct ccctggttaa tctctctacg gcttcctccg 5700 cccctcctac ccgggtcaga cgtagtcccg tcgcggccct gaccttaggc ctagccctgt 5760 cagtggggct cactggcatt aatgtggccg tgtctgccct tagccatcag agactcacct 5820 ccctgatcca cgttctggag caagatcagc aacgcttgat cacagcaatt aatcagaccc 5880 actataattt gcttaatgtg gcctctgtgg ttgcccagaa ccgacggggg cttgattggt 5940 tgtacatccg gctgggtttt caaagcctat gtcccacaat taatgagcct tgctgtttcc 6000 tgcgcattca aaatgactcc attatcctcc gcggtgatct ccagcctctc tcgcaaagag 6060 tctctacaga ctggcagtgg ccctggaatt gggatctggg gctcactgcc tgggtgcgag 6120 aaaccattca ttctgttcta agcctgttcc tattagccct ttttttgctc ttcctggccc 6180 cctgcctgat aaaatgcttg acctctcgcc ttttaaagct cctccggcag gctccccact 6240 tccctgaaat ctccttaacc cctaaacccg attctgatta tcaggccttg ctaccatctg 6300 caccagagat ctactctcac ctctcccccg tcaaacccga ttacatcaac ctccgaccct 6360 gcccttgata cccccgcgtt tcacgcaccc ccaggctgtg gtggtgcact ggcttagtgg 6420 agtagtcagt gtaccatcac aagcctcttc ttgctgccag caccgagttc gaacacagct 6480 ctaccctgag cctctctgag tgcatgactg agtgtagcgc agagagattg tcgcttctgc 6540 gtgtcgctca gtcatttttt atagccgatt ggggttcgcg cccttccgtt gcctgtgaca 6600 cagataagac ctctctcact tctgcttcac catccccctg ccagcgttgg tctagtggaa 6660 agaactaacg ctgacggggg cgatttcttg cagctgtgct agcgggaggc tctggtgctg 6720 gggataagat gtggccctta gcaccacagt ctctgcgcct tttgggttcg aatcttcccc 6780 acgcagcttc cgctttttac gccctgttgc acaccctttc tagagatacc tgaaaatctc 6840 agctcgcacc ctgaggaagg ttgtggctca gaggttaaaa tagctcgagc cgcaacctcc 6900 ctttcttttt attccaccct cgcaaggccc cgggttctga gccccctaac ggaggttcaa 6960 aatttcctct acaaggggat gctcgggtcc aagtgtgcac aatatctctt ccaaaaggtc 7020 ctgatgaacg tcttcccatg taacaagccc cagcagagac attccagcca catccagcag 7080 catttgggcc gccttttcta acagtgccca taaagtccct tccgtttcca caacggctgc 7140 ctctgcatct tctatttcca cctcggcacc gactcccccg ccgagccctt cgagctcttc 7200 gggatccatt acctgataac gacaaaatta tttcttgtct tttaagcaag tgttgttggt 7260 tgggggcccc actctctaca tgcctgcccg gccctggttt tgtccaatga tgtcaccatc 7320 gatgcctggt gccccctctg cgggccccat gagcgactcc aattcgaaag gatcgacacc 7380 acgctcacct gcgagaccca ccgtatcaac tggaccgccg atggacgacc ttgcggcctc 7440 aatggaacgt tgttccctcg actgcatgtc tccgagaccc gcccccaagg gccccgacga 7500 ctctggatca actgccccct tccggccgtt cgcgctcagc ccggcccggt ttcactttcc 7560 cccttcgagc ggtccccctt ccagccctac caatgccaat tgccctcggc ctctagcgac 7620 ggttgcccca ttatcgggca cggccttctt ccctggaaca acttagtaac gcatcctgtc 7680 ctcggaaaag tccttatatt aaatcaaatg gccaattttt ccttactccc ctccttcgat 7740 accctccttg tggaccccct ccggctgtcc gtctttgccc cagacaccag gggagccata 7800 cgttatctct ccaccctttt gacgctatgc ccagctactt gtattctacc cctaggcgag 7860 cccttctctc ctaatgtccc catatgccgc tttccccggg actccaatga accccccctt 7920 tcagaattcg agctgccccc catccaaacg cccggcctgt cttggtctgt ccccgcgatc 7980 gacctattcc taaccggtcc cccttcccca tgtgaccggt tacacgtatg gtccagtcct 8040 caggccttac agcgcttcct tcatgaccct acgctaacct ggtccgaatt ggttgctagc 8100 agaaaaataa gacttgattc ccccttaaaa ttacaactgc tagaaaatga atggctctcc 8160 cgcctttttt gagggggagt catttgtatg aaagatcatg ccgacctagg agccgccacc 8220 gccccgtaaa ccagacagag acgtcagctg ccagaaaagc tggtgacggc agctggtggc 8280 tagaatcccc gtacctcccc aacttcccct ttcccgaaaa atccacaccc tgagctgctg 8340 acctcacctg ctgataaatt aataaaatgc cggccctgtc gagttagcgg caccagaagc 8400 gttcttctcc tgagaccctc gtgctcagct ctcggtcctg agctctcttg ctcccgagac 8460 cttctggtcg gctatccggc agcggtcagg taaggcaagc acggtttgga gggtggttct 8520 cggctgagac caccgcgagc tctatctccg gtcctctgac cgtctccacg tggactctct 8580 cctttgcctc ctgaccccgc gctccaaggg cgtctggctt gcacccgcgt ttgtttcctg 8640 tcttactttc tgtttctcgc ggcccgcgct ctctccttcg gcgccctcta gcggccagga 8700 gagaccggca aaca 8714 // |
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