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EBI DbfetchID K02022; SV 1; linear; genomic DNA; STD; VRL; 2579 BP. XX AC K02022; M11853; XX DT 13-JUN-1985 (Rel. 06, Created) DT 09-SEP-2004 (Rel. 81, Last updated, Version 4) XX DE HSV1 (KOS) alkaline exonuclease gene, 0.175-0.160 map units. XX KW exonuclease. XX OS Human herpesvirus 1 (Herpes simplex virus type 1) OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Alphaherpesvirinae; Simplexvirus. XX RN [1] RP 1-1000 RX PUBMED; 6313961. RA Costa R.H., Draper K.G., Banks L., Powell K.L., Cohen G., Eisenberg R., RA Wagner E.K.; RT "High-resolution characterization of herpes simplex virus type 1 RT transcripts encoding alkaline exonuclease and a 50,000-dalton protein RT tentatively identified as a capsid protein"; RL J. Virol. 48(3):591-603(1983). XX RN [2] RP 73-2579 RX PUBMED; 3005609. RA Draper K.G., Devi-Rao G., Costa R.H., Blair E.D., Thompson R.L., RA Wagner E.K.; RT "Characterization of the genes encoding herpes simplex virus type 1 and RT type 2 alkaline exonucleases and overlapping proteins"; RL J. Virol. 57(3):1023-1036(1986). XX CC Four partially overlapping mRNA's (1.9, 2.3, 3.9 and 4.5 kb) were CC found between map units 0.16 and 0.19 on the HSV-1 genome. Their CC direction of transcription was found to be from right to left. The CC 2.3 kb mRNA was found to be early, whereas the other three were CC late. The 2.3 kb mRNA was shown to encode an alkaline exonuclease CC whose coding sequence extends past the start of the 1.9 kb mRNA. CC The product of the 1.9 kb mRNA is putatively a capsid protein, but CC this remains to be proven [1]. CC A draft entry and computer-readable copy of the sequence in [2] was CC kindly provided by K.G.Draper 30-APR-1986. XX FH Key Location/Qualifiers FH FT source 1..2579 FT /organism="Human herpesvirus 1" FT /mol_type="genomic DNA" FT /db_xref="taxon:10298" FT CDS <1..375 FT /codon_start=1 FT /product="capsid protein" FT /db_xref="UniProtKB/TrEMBL:Q68977" FT /protein_id="AAA45770.1" FT /translation="VSVYVAPSLGVPVTRFPGYQYFNNQLSPDFALALLAYRCVLHPAL FT FVNSAETNTHGLAYDVPEGIRRHLRNPKIRRAFTDRCINYQHTHKAILSSVALPPELKP FT LLVLVSRLCHTNPCARHALS" FT mRNA 271..>2314 FT /gene="AE" FT /note="2.3 kb mRNA" FT mRNA 273..>2314 FT /gene="AE" FT /note="2.3 kb mRNA" FT /citation=[1] FT CDS 434..2314 FT /codon_start=1 FT /gene="AE" FT /product="alkaline exonuclease" FT /db_xref="GOA:Q68978" FT /db_xref="InterPro:IPR001616" FT /db_xref="UniProtKB/TrEMBL:Q68978" FT /protein_id="AAA45771.1" FT /translation="MESTGGPACPPGRTVTKRSWALAEDTPRGPDSPPKRPRPNSLPLT FT TTFRPLPPPPQTTSAVDPSSHSPVNPPRDQHATDTADEKPRAASPALSDASGPPTPDIP FT LSPGGTHARDPDADPDSPDLDSMWSASVIPNALPSHILAETFERHLRGLLRGVRAPLAI FT GPLWARLDYLCSLAVVLEEAGMVDRGLGRHLWRLTRRAPPAAADAVAPRPLMGFYEAAT FT QNQADCQLWALLRRGLTTASTLRWGPQGPCFSPQWLKHNASLRPDVQSSAVMFGRVNEP FT TARSLLFRYCVGRADDGGEAGADTRRFIFHEPSDLAEENVHTCGVLMDGHTGMVGASLD FT ILVCPRDIHGYLAPVPKTPLAFYEVKCRAKYAFDPMDPSDPTASAYEDLMAHRSPEAFR FT AFIRSIPKPSVRYFAPGRVPGPEEALVTQDQAWSEAHASGEKRRCSAADRALVELNSGV FT VSEVLLFGAPDLGRHTISPVSWSSGDLVRREPVFANPRHPNFKQILVQGYVLDSHFPDC FT PPHPHLVTFIGRHRTSAEEGVTFRLEDGAGALGAAGPSKASILPNQAVPIALIITPVRI FT DPEIYKAIQRSSRLAFDDTLAELWASRSPGPGPAAAETTSSSPTTGRSSR" FT mRNA 681..2538 FT /note="1.9 kb" FT mRNA 681..2546 FT /note="1.9 kb" FT CDS 812..2314 FT /codon_start=1 FT /gene="AE" FT /note="1.9kD ORF" FT /db_xref="GOA:Q68979" FT /db_xref="InterPro:IPR001616" FT /db_xref="UniProtKB/TrEMBL:Q68979" FT /protein_id="AAA45772.1" FT /translation="MWSASVIPNALPSHILAETFERHLRGLLRGVRAPLAIGPLWARLD FT YLCSLAVVLEEAGMVDRGLGRHLWRLTRRAPPAAADAVAPRPLMGFYEAATQNQADCQL FT WALLRRGLTTASTLRWGPQGPCFSPQWLKHNASLRPDVQSSAVMFGRVNEPTARSLLFR FT YCVGRADDGGEAGADTRRFIFHEPSDLAEENVHTCGVLMDGHTGMVGASLDILVCPRDI FT HGYLAPVPKTPLAFYEVKCRAKYAFDPMDPSDPTASAYEDLMAHRSPEAFRAFIRSIPK FT PSVRYFAPGRVPGPEEALVTQDQAWSEAHASGEKRRCSAADRALVELNSGVVSEVLLFG FT APDLGRHTISPVSWSSGDLVRREPVFANPRHPNFKQILVQGYVLDSHFPDCPPHPHLVT FT FIGRHRTSAEEGVTFRLEDGAGALGAAGPSKASILPNQAVPIALIITPVRIDPEIYKAI FT QRSSRLAFDDTLAELWASRSPGPGPAAAETTSSSPTTGRSSR" FT mRNA 1820..2546 FT /note="0.9 kb" FT mRNA 1820..2538 FT /note="0.9 kb" FT CDS 2230..2520 FT /codon_start=1 FT /note="0.9kD ORF" FT /db_xref="GOA:Q68980" FT /db_xref="InterPro:IPR016395" FT /db_xref="UniProtKB/TrEMBL:Q68980" FT /protein_id="AAA45773.1" FT /translation="MGLSFSGARPCCCRNNVLITDDGEVVSLTAHDFDVVDIESEEEGN FT FYVPPDMRVVTRAPGRQRLRSSDPPSRHTHRRTPGGACPATQFPPPMSDSE" XX SQ Sequence 2579 BP; 416 A; 978 C; 746 G; 439 T; 0 other; gttagcgtgt acgtcgcccc gagcctgggc gtacccgtga cccggtttcc cggttaccag 60 tatttcaaca accagctgtc gccggacttc gccctggccc tgctcgccta tcgctgcgtg 120 ctgcacccag ccctgtttgt caactcggcc gagaccaaca cccacggcct ggcgtatgac 180 gtcccagagg gcatccggcg ccacctccgc aatcccaaga ttcggcgcgc gtttacggat 240 cggtgtataa attaccagca cacacacaag gcgatactgt cgtcggtggc gctgcctccc 300 gagcttaagc ctctcctggt gctggtgtcc cgcctgtgtc acaccaaccc gtgcgcgcgg 360 cacgcgctgt cgtgagaatc agcgttcacc cggcggcgcg ctcaaccacc gctcccccca 420 cgtcgtctcg gaaatggagt ccacgggagg cccagcatgt cctccgggac gcaccgtgac 480 taagcgttcc tgggccctgg ccgaggacac ccctcgtggc cccgacagcc cccccaagcg 540 cccccgccct aacagtcttc cgctgacaac caccttccgt cccctgcccc ccccacccca 600 gacgacgtca gctgtggacc cgagctccca ttcgcccgtt aaccccccac gtgatcagca 660 cgccaccgac accgcagacg aaaagccccg ggccgcgtcg ccggcacttt ctgacgcctc 720 cgggcctccg accccggaca ttccgctatc tcctgggggc acccacgccc gcgacccgga 780 cgccgatccc gactccccgg accttgactc tatgtggtcg gcgtcggtga tccccaacgc 840 gctgccctcc catatactag ccgagacgtt cgagcgccac ctgcgcgggt tgctgcgcgg 900 cgtccgcgcc cctctggcca tcggtcccct ctgggcccgc ctggattatc tgtgttccct 960 ggccgtggtc ctcgaggagg cgggtatggt ggaccgcgga ctcggccggc acctatggcg 1020 cctgacgcgc cgcgcccccc cggccgccgc ggacgccgtg gcgccccggc ccctcatggg 1080 gttttacgag gcggccacgc aaaaccaggc cgactgccag ctatgggccc tgctccggcg 1140 gggcctcacg accgcatcca ccctccgctg gggcccccag ggtccgtgtt tctcgcccca 1200 gtggctgaag cacaacgcca gcctgcgacc ggatgtacag tcttcggcgg tgatgttcgg 1260 gcgggtgaac gagccgacgg cccgaagcct gctgtttcgc tactgcgtgg gccgcgcgga 1320 cgacggcggc gaggccggcg ccgacacgcg gcgctttatc ttccacgaac ccagcgacct 1380 cgccgaagag aacgtgcata cgtgtggggt cctcatggac ggtcacacgg ggatggtcgg 1440 ggcgtccctg gatattctcg tctgtcctcg ggacattcac ggctacctgg ccccagtccc 1500 caagaccccc ctagcctttt acgaggtcaa atgccgggcc aagtacgctt tcgaccccat 1560 ggaccccagc gaccccacgg cctccgcgta cgaggacttg atggcacacc ggtccccgga 1620 ggcgttccgg gcatttatcc ggtcgatccc gaaacccagc gtgcgatact ttgcgcccgg 1680 gcgcgtcccc ggcccggagg aggctctcgt cacacaagac caggcctggt cagaggccca 1740 cgcctcgggc gaaaaaaggc ggtgctccgc cgcggatcgg gccttggtgg agttaaatag 1800 cggcgttgtc tcggaggtgc ttctgtttgg cgcccccgac ctcggacgcc acaccatctc 1860 ccccgtgtcc tggagctccg gggatctggt ccgccgcgag cccgtcttcg cgaacccccg 1920 tcacccgaac tttaagcaga tcttggtgca gggctacgtg ctcgacagcc acttccccga 1980 ctgccccccc cacccgcatc tggtgacgtt tatcggcagg caccgcacca gcgcggagga 2040 gggcgtaacg ttccgcctgg aggacggcgc cggggctctc ggggccgcag gacccagcaa 2100 ggcgtccatt ctcccgaacc aggccgttcc gatcgccctg atcattaccc ccgtccgcat 2160 cgatccggag atctataagg ccatccagcg aagcagccgc ctggcgttcg acgacacgct 2220 cgccgagcta tgggcctctc gttctccggg gcccggccct gctgctgccg aaacaacgtc 2280 ctcatcaccg acgacgggga ggtcgtctcg ctgaccgccc acgactttga cgtcgtggat 2340 atcgagtccg aagaggaagg taatttctac gtgcccccgg atatgcgcgt ggttacgcgg 2400 gccccgggga gacagcgcct gcgttcgtcg gaccccccct cgcgccacac tcaccggcgg 2460 acccccggag gcgcctgccc cgccacccag tttccacccc ccatgtccga tagcgaataa 2520 aaaccaaaat aatgttctgt atacggtcgc acgcgtgtcg tttttaaaaa acccacaat 2579 // |
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