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EBI DbfetchID J02986; SV 1; linear; genomic DNA; STD; HUM; 6616 BP. XX AC J02986; M16338; XX DT 02-APR-1988 (Rel. 15, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 13) XX DE Homo sapiens transforming protein (FGF4) gene, complete cds; and unknown DE gene. XX KW transforming protein. XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RP 2313-2890, 3508-3611, 6182-6616 RX DOI; 10.1073/pnas.84.9.2980 RX PUBMED; 2953031. RA Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., Sugimura T.; RT "cDNA sequence of human transforming gene hst and identification of the RT coding sequence required for transforming activity"; RL Proc. Natl. Acad. Sci. U.S.A. 84(9):2980-2984(1987). XX RN [2] RC Erratum:[[published erratum appears in Proc Natl Acad Sci U S A 1988 RC Mar;85(6):1967]] RP 1-6616 RX DOI; 10.1073/pnas.84.20.7305 RX PUBMED; 2959959. RA Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F., Terada M., RA Sugimura T.; RT "Genomic sequence of hst, a transforming gene encoding a protein homologous RT to fibroblast growth factors and the int-2-encoded protein"; RL Proc. Natl. Acad. Sci. U.S.A. 84(20):7305-7309(1987). XX DR GDB; 169547. XX CC Draft entry and printed copy of sequence for [1],[2] kindly CC provided by H.Sakamoto, 08/06/87. CC No polyadenylation site was found. XX FH Key Location/Qualifiers FH FT source 1..6616 FT /organism="Homo sapiens" FT /chromosome="11" FT /map="11q13.3" FT /mol_type="genomic DNA" FT /clone="pLBS6.2; lambda-CT361-b3" FT /cell_line="T361-2nd-1 stomach cancer" FT /db_xref="taxon:9606" FT exon 2313..2890 FT /number=1 FT /note="transforming protein" FT variation 2444 FT /replace="t" FT /note="c in DNA, t in cDNA" FT variation 2474 FT /replace="t" FT /note="c in DNA, t in cDNA" FT CDS join(2551..2890,3508..3611,4150..4326) FT /codon_start=1 FT /gene="FGF4" FT /product="transforming protein" FT /db_xref="GDB:120066" FT /db_xref="GOA:P08620" FT /db_xref="HGNC:3682" FT /db_xref="InterPro:IPR002348" FT /db_xref="PDB:1IJT" FT /db_xref="UniProtKB/Swiss-Prot:P08620" FT /protein_id="AAB59555.1" FT /translation="MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELER FT RWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRI FT GGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLP FT NNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL" FT intron 2891..3507 FT /gene="FGF4" FT /note="hst intron A" FT exon 3508..3611 FT /gene="FGF4" FT /number=2 FT intron 3612..4149 FT /gene="FGF4" FT /note="hst intron B" FT exon 4150..>6181 FT /number=3 FT /note="transforming protein" FT variation 4383 FT /replace="a" FT /note="g in DNA, a in cDNA" FT CDS 4685..5149 FT /codon_start=1 FT /product="unknown" FT /note="ORF; putative" FT /db_xref="GOA:Q14569" FT /db_xref="UniProtKB/TrEMBL:Q14569" FT /protein_id="AAB59556.1" FT /translation="MAWSISVWKGPPEAWAASSGSSQAWLSASILRGPLPLCPVAINRD FT ISVYFGYRKCGVEVLAATLFLDLPRLTFELSCSQSSSIYQMGETLGQLYKLLFAFFGSA FT TAPIAVTIGEKTKLFHKFHGEESISHWKARNGQDSVFAITNKTLVMKNNL" XX SQ Sequence 6616 BP; 1404 A; 1833 C; 1984 G; 1395 T; 0 other; ggatccagaa ggcatccccg agtggctact ccaatggagt ggcttctcca ttcaggcaaa 60 cctgaatggg ataagtcatt ggcaggaaga tctggggccg ggggtcatcc agtgggaagg 120 ggagagatga cgcggtcagc atggcgggaa cacaggagca gaaaggaagc aggtgggaag 180 ccaggtcaag ggccaggggc acggaaaggg gtcagatgca gataagtgag tgcttcctgg 240 tgcatccttc atccgcaatt catccttacc tgtgcttttg ttgcctccat tgcacagctg 300 aggaggccag ggcctgcgga ggttgagagt gtgctcaggg agcccccgga gcaaagtgga 360 agccagattc cagatcagtt ctgctgggaa ttcccagctc ccaaaagccc tgctggctgt 420 cagtccccag tcaccacaag cacctatcct gtgtgggtgg gcctgcagtt ctgggagata 480 tatcagctgc ctgcagcgtc ctttgctgaa ctcacagcaa ataggagaga cagggagggg 540 tccttgggaa gccctaaatt gagcttgctg tgggagtcct gggaagaaag gagcctcatc 600 ctatcaaaag ccggggggaa gacatcagag tccctctgct caggtcagct ggcacaggtg 660 ggtctccagg cctgggtctc acttccccag agggtgtgtt cgggtggccc caggctgagg 720 gaggaaagcc cacctcccat gtcattttgc aaatggggag tcagggacct agagatggaa 780 agacaacaca gcaagtgagg gatgggttct aggtcccctg caccctgcac cctgcaccct 840 ggccaacgat gtctatttgg caccagatct gcaggctcat ctgggggacc ccaggaccca 900 gaggcagccg ggttgcatct cgaagctgtg agctgcagcc caggaaggtc caggtctggg 960 tggcgctgcc caagcaggct gcaggcccaa ggaggaacaa agatcctctc aaggggtgcg 1020 gagctgaggt tccggtcctg ccaaagccac ttgatgaccc ccaagtgccc ccctttctgc 1080 acctcagaga agagccctca agcctcccag gtcccctcca ggggcacgaa taagccccag 1140 cagggttctg aaggggtccc aggaatctcc ctgtggggat gcggtggagg tggaggaggc 1200 tgcggtggcc tggggacatc tctggtcaca ggtgctggtg gtatgagaga tggggtaggc 1260 accaagcccc ctgcagctgt ggctaggcgg gcctgcagga agggccaggc aggctcctca 1320 gggaccacaa agaacagggg ttttcacacc taggtgggcc tgcatctagc taggccagtc 1380 cccatcaggc cataatgggc acagtgggag gtagaaccat gagtgagaga ggggaggctt 1440 ccagaggcct ggcctgggtc cctgctagat tgagggctct ggctatggta catggatatt 1500 tctgctgtgg aatcaaagga gcaggggatg ctgaatatcc cctctggccc tatgccctgc 1560 tacctgtcct ttcacggaag ggtgtgtgtg tagggggtgc aggaccaggc ctccctgggt 1620 gcatctctgc caccttgccc tttggctcag gtggacctcc accaggtatt cagaactcca 1680 gcccagaaac gcgccaagcc tgtggggcca agacctaggg ggtgggggtg gcctccctcc 1740 cgcctgtagc caaagggtcc tcccttgccc agccaggccc cggtgtcgct tactgctctt 1800 atccacccct ccttcccagg ccggtcctca aggccccagc aaaggaacca agttcccgtg 1860 agcctccgaa aggcgaaggg caggcagcag ccgctggctt ctgcgcccac taggagcttc 1920 ggatgcccga gttagggctg cgccaaggcg gccggagcag agagggagac ggggacgggg 1980 acaggcaggg acaaagtgca agaggcaaaa ctggctgaaa agcagaagtg taggagccgc 2040 caaggggcgg gacgaacagg tccgtgggcc gggcggagcc aagggtgggg gccggggtcc 2100 ctccaggtgg cactcgcggc gctagtcccc agcctcctcc cttcccccgg ccctgattgg 2160 caggcggcct gcgaccagcc gcgaacgcca cagcgccccg ggcgcccagg agaacgcgaa 2220 cggccccccg cgggagcggg cgagtaggag ggggcgccgg gctatatata tagcggctcg 2280 gcctcgggcg ggcctggcgc tcagggaggc gcgcactgct cctcagagtc ccagctccag 2340 ccgcgcgctt tccgcccggc tcgccgctcc atgcagccgg ggtagagccc ggcgcccggg 2400 ggccccgtcg cttgcctccc gcacctcctc ggttgcgcac tcccgcccga ggtcggccgt 2460 gcgctcccgc gggccgccac aggcgcagct ctgcccccca gcttcccggg cgcactgacc 2520 gcctgaccga cgcacggccc tcgggccggg atgtcggggc ccgggacggc cgcggtagcg 2580 ctgctcccgg cggtcctgct ggccttgctg gcgccctggg cgggccgagg gggcgccgcc 2640 gcacccactg cacccaacgg cacgctggag gccgagctgg agcgccgctg ggagagcctg 2700 gtggcgctct cgttggcgcg cctgccggtg gcagcgcagc ccaaggaggc ggccgtccag 2760 agcggcgccg gcgactacct gctgggcatc aagcggctgc ggcggctcta ctgcaacgtg 2820 ggcatcggct tccacctcca ggcgctcccc gacggccgca tcggcggcgc gcacgcggac 2880 acccgcgaca gtgagtggcg cggccaggcg cgaaggggcg ggggcggggg gcaacggccg 2940 ccgggccaac ccgctcagtc acactctgag accctcggcg ggcacctgct cgggggcccc 3000 gggaaccggg gcggactcgg gctccggtcc cttctgacgc ggggctgggg acgcagacac 3060 tcttggctcc ggcagcccag cgcaacccct gaggtcgggc gccgcctccc gccttcagaa 3120 actcgggctc cgagcgccga attccagcgc cttcgcccgt gggcacaggg cgcgcggtgc 3180 agccacaggg ggcccgagac acgcgccccg gcctggccca ggctggggaa ccgctggggt 3240 cgggctcgcg tctgaaggtc cgggactggg tgcggccgcc gggggtcccc tacacaggca 3300 agctaatctg agctagcgca ggcttgggct ccggaggccc tagagggcag cttgggctct 3360 ggaggccctt gggggcggct gcgccgggaa ccctggccct ttatccccaa ccccacccca 3420 gaaatagggt ccccggaggc gaacaagccg aggggcggag tgggccaggg atcacctgcc 3480 ccgcaatgac ctgcgccccg cccccaggcc tgctggagct ctcgcccgtg gagcggggcg 3540 tggtgagcat cttcggcgtg gccagccggt tcttcgtggc catgagcagc aagggcaagc 3600 tctatggctc ggtgagtacc gcaggggtct ggctaggcac ctagttggga acagcggaca 3660 tggctagcag gctcgtggct tctccagccc cacctgtgcc tgggtcttgg aggggtggca 3720 gggtcaccag gtcacgggac cggcaggcct ccccagacaa aggaagcagc cccaaggcag 3780 gaacaatgag gttcctgcca tccctgagtg ggcccctccc agaccgagga aagggcgcta 3840 ttgagagccc ttcccttctc tagtccagag gggtaggtct cagtgttgga actgcgggct 3900 tgaggctgga cacgcaggga atgaattctc tggctgctag gtgcagggca ggtggtgaga 3960 gcaccagctg ttgtgggctg gccatgtccc cttctcaccc tgtgtgggtc ttgacacctt 4020 aactgctcag cagagacatc tcagcccagg gtggggggtg ggacagaagg gggttctgac 4080 ccctggcttc aggctgggta ccttgcccaa gaggtgcccc agccctgaca ctgccctgct 4140 ttgctgcagc ccttcttcac cgatgagtgc acgttcaagg agattctcct tcccaacaac 4200 tacaacgcct acgagtccta caagtacccc ggcatgttca tcgccctgag caagaatggg 4260 aagaccaaga aggggaaccg agtgtcgccc accatgaagg tcacccactt cctccccagg 4320 ctgtgaccct ccagaggacc cttgcctcag cctcgggaag cccctgggag ggcagtgccg 4380 agggtcacct tggtgcactt tcttcggatg aagagtttaa tgcaagagta ggtgtaagat 4440 atttaaatta attatttaaa tgtgtatata ttgccaccaa attatttata gttctgcggg 4500 tgtgtttttt aattttctgg ggggaaaaaa agacaaaaca aaaaaccaac tctgactttt 4560 ctggtgcaac agtggagaat cttaccattg gatttcttta acttgtcaaa agttgtcacg 4620 agtgtgctgc tattctgtgt tttaaaaaaa ggtgacattg gattccgatg tcatcccctg 4680 tagtatggcg tggagcatct ctgtctggaa aggcccgcct gaggcttggg cagccagttc 4740 agggagctcc caggcttggc tctcggctag catcctcaga ggcccactcc ctttgtgccc 4800 tgttgctatt aatcgggaca tatcggttta cttcgggtac agaaagtgcg gtgttgaagt 4860 cctcgctgcc actctgtttt tagatctgcc aagactgacc tttgaacttt cctgtagtca 4920 atcttcctcg atctaccaga tgggagagac ccttggacaa ctttataaac tcctgtttgc 4980 cttttttgga tcagcgacag cccccatcgc tgtgactatt ggggaaaaga cgaagctctt 5040 tcataaattc catggagagg aatcaatatc ccactggaag gctagaaatg gacaagatag 5100 tgtatttgca atcacaaaca aaaccctagt gatgaaaaat aatttgtgat ggcagatgct 5160 tctgatggtg tgatagaata tgtttttgaa aacaaaccat cgaacccccc gccccacccc 5220 caaaacgggc ttccctgtgt ttagggagct ttgggctaga actagctacg atttttaggt 5280 gaaatgtcct tgtaattgta caaagcactt ggtgcagtgt ttgcgtggag cagcctgctg 5340 ctttctgatg cattccctgt ttaagtgcgt ttaacatcta cctcacaagc cctgaaaccc 5400 caggcaaaac ccacagaaag ctcatacccg gtgcaggagt ttgccatccc aagtggcttt 5460 ttttccatat gtagccaaaa aggattgcag atagcgtcgg tgcgtcccat tcgaaccttg 5520 tcacgtttga gctatcttta ccctgtgatt tacttttagt aagggtgatc atggtgaaaa 5580 tatttgcaga cagctgttac agtacactat atggtcacca agtaacctta tatttttctt 5640 tatatatttt acaaatgtaa cccctgtcat tgaagcaacc gtggaagagg cagggtcggt 5700 gatgtttaaa aaaagttccg aggtgatggc aaacatttaa ttttaatgaa tgacttttta 5760 gagtttatac aaaatgacct tagcttgcta ccagaaatgc tccgaatgtt tcgtcaagac 5820 tttaatactc tcctaggatg tttctgaact gtctcccgaa ttaactttat gggagtctac 5880 agacagcaag actggaaaat ctgattggag tttttgtctt tcacattcct tttgaaaact 5940 ctttgttcga atgcaaatca tcgacttaaa atactattct taaccaaggc ctggaagaaa 6000 gaagacactt gcaaagccgc taagacagga ccacacatct taaactgctg ttcctaccat 6060 gcactaaact gtttttaagt tttaaaccac accctaggct ccaggagtgt tcaggaaaga 6120 tggtgtttgt aggtctccat gctgtttggc gttggggggt gtggagggat catccgtcga 6180 ctttctgaat tttaatgtat tcacttagta acaaaccatg attgtcttaa atgccttaaa 6240 ttattatgag atttcttgtc tcagagccca atcagattgt caggaattaa catgtgttag 6300 gtttgatcac ccttgaccac ttcttataga tatttcttca acaaatcatg tgtgatgcct 6360 gtaggaacac aactgtacct ttaaaatatt gttttcatat tgctgtgatg gggattcgag 6420 gttcctgtat gtgccactgt tttcagaatc tgtagtttta tacaggtgcc gaccctcgtt 6480 gtgatgtatg tgctgtgcac attgacatgc tgaccgacaa tgataagcgt ttatcgtgta 6540 taaaaagaca ccactggact ggatgtacac aactgggaaa ggaattaaaa gctattaaaa 6600 ttgtgccttg aaatgc 6616 // |
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