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EBI DbfetchID EF990365; SV 1; linear; genomic DNA; STD; PRO; 12864 BP. XX AC EF990365; XX DT 06-OCT-2007 (Rel. 93, Created) DT 06-OCT-2007 (Rel. 93, Last updated, Version 1) XX DE Streptococcus agalactiae strain DSM2134 capsular polysaccharide synthesis DE gene locus, complete sequence. XX KW . XX OS Streptococcus agalactiae OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus. XX RN [1] RP 1-12864 RX DOI; 10.1128/JCM.01296-07 RX PUBMED; 17715372. RA Martins E.R., Melo-Cristino J., Ramirez M.; RT "Reevaluating the serotype II capsular locus of Streptococcus agalactiae"; RL J. Clin. Microbiol. 45(10):3384-3386(2007). XX RN [2] RP 1-12864 RA Martins E., Ramirez M., Melo-Cristino J.; RT ; RL Submitted (22-JUN-2007) to the EMBL/GenBank/DDBJ databases. RL Molecular Microbiology and Infection Unit, Institute of Molecular Medicine, RL Av. Prof. Egas Moniz, Lisbon 1649-028, Portugal XX FH Key Location/Qualifiers FH FT source 1..12864 FT /organism="Streptococcus agalactiae" FT /strain="DSM2134" FT /serotype="II" FT /mol_type="genomic DNA" FT /db_xref="taxon:1311" FT misc_feature 1..12864 FT /note="capsular polysaccharide synthesis gene locus" FT gene 93..1442 FT /gene="cps2E" FT CDS 93..1442 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2E" FT /product="glycosyl transferase" FT /db_xref="GOA:Q8VT73" FT /db_xref="InterPro:IPR017475" FT /db_xref="UniProtKB/TrEMBL:Q8VT73" FT /protein_id="ABV59018.1" FT /translation="MIQTVVVYFSASLTLTLITPNFKSNKDLLFVLLIHYIVFYLSDFY FT RDFWSRGYLEEFKMVLKYSFYYIFISSSLFFIFKNSFTTTRLSFFTFIAMNSILLYLLN FT SFLKYYRKYSYAKFSRDTKVVLITNKDSLSKMTFKNKYDHNYIAVCILDSSEKDCYDLK FT HNSLRIINKDALTSELTCLTVDQAFINIPIELFGKYQIQDIINDIEAMGVIVNVNVEAL FT SFDNIGEKRIQTFEGYSVITYSMKFYKYSHLIAKRFLDIMGAIIGLLICGIVAIFLVPQ FT IRKDGGPAIFSQNRVGRNGRIFRFYKFRSMRVDAEQIKKDLLVHNQMTGLMFKLDDDPR FT ITKIGKFIRKTSIDELPQFYNVLKGDMSLVGTRPPTVDEYEKYNSTQKRRLSFKPGITG FT LWQISGRNNITDFDEIVKLDVQYINEWSIWSDIKIILLTLKVVLLGTGAK" FT gene 1466..1915 FT /gene="cps2F" FT CDS 1466..1915 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2F" FT /product="beta-1,4-galactosyl transferase enhancer" FT /db_xref="GOA:Q9RPC6" FT /db_xref="InterPro:IPR013969" FT /db_xref="UniProtKB/TrEMBL:Q9RPC6" FT /protein_id="ABV59019.1" FT /translation="MKICLVGSSGGHLAHLNLLKPIWEKEDRFWVTFDKEDARSILREE FT IVYHCFFPTNRNVKNLVKNTILAFKVLRKERPDVIISSGAAVAVPFFYIGKLFGCKTVY FT IEVFDRIDKPTLTGKLVYPVTDKFIVQWEEMKKVYPKAINLGGIF" FT gene 1915..2406 FT /gene="cps2G" FT CDS 1915..2406 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2G" FT /product="beta-1,4-galactosyl transferase" FT /db_xref="GOA:A8JZX1" FT /db_xref="InterPro:IPR007235" FT /db_xref="UniProtKB/TrEMBL:A8JZX1" FT /protein_id="ABV59020.1" FT /translation="MIFVTVGTHEQQFNRLIKEVDRLKGTGAIDQEVFIQTGYSDFEPQ FT NCQWSKFLSYDDMNSYMKEAEIVITHGGPATFMNAVSKGKKTIVVPRQEQFGEHVNNHQ FT VDFVNKVKTMYNFDIVVDIERLQNVVYEGTMNRPFLETNRSNFIEEFKVILKELCDENQ FT " FT gene 2390..3499 FT /gene="cps2H" FT CDS 2390..3499 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2H" FT /product="CPS polymerase" FT /db_xref="UniProtKB/TrEMBL:A8JZX2" FT /protein_id="ABV59021.1" FT /translation="MMKINKNKNYFFEVIFIILFSLLALYTGVYRDGNYLYDYLFLLYA FT FYAFLRSITITYSRKEIIILISVTILFVLNSFFSKGNSWLSILIILLGSRKIAIDRIID FT SLLICKIISFIGVLTFVNLHILENKQVLTYRYGEVVARYAYGFNHPNTLHAFFFIIIML FT FIYRFFTKLKYLHLVIILIINQYIYSISVARTGYFLVIFAVVFYIILRNNFLIQQITFK FT IAPYVQFIAMFSLLLFSLFFFNTPIVSKLDNLLSGRIYYAKLILTDSLNLFGNEINYFI FT DRYILFFHDNSYSSTLALSGIIITFGYMYLYFKTSRKLVQDHNIAALYLFVSNSLLFYS FT EDYIREPFLNITLFFIGKYIFNELGEINE" FT gene 3492..4463 FT /gene="cps2I" FT CDS 3492..4463 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2I" FT /product="beta-1,3-N-acetylglucosaminyl transferase" FT /db_xref="GOA:A8JZX3" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:A8JZX3" FT /protein_id="ABV59022.1" FT /translation="MSDKFSNKISVIVPLYNVEKYIINCISSLTNQTYQNIEIILIDDG FT STDNSGRICKKLAQEDHRIIYLRKENGGVSSARNLGLQYATGSYIGFVDSDDYISKTMY FT ENLLKRLLETNADIAETDFALIDNRFTKKKRKKIQKVLNKEEAIREFLSGNVVENNLVI FT KLFKKTVIANLKFKEDVIVGEDMLFSLQALLNSDRVTVDTTNADYFYVVRSNSTMNTIT FT EKDIDNLSILEQEFKKIDIPQLKSYLEAKLIREKVKFVSRVLISNKAHLYSDIIDRYLQ FT EVRHYSIKNMINFLSSKHCLTITIMKISPKLYTLLYKVFQKQ" FT gene 4485..5450 FT /gene="cps2J" FT CDS 4485..5450 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2J" FT /product="putative glycosyl transferase" FT /db_xref="GOA:A3KLK8" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:A3KLK8" FT /protein_id="ABV59023.1" FT /translation="MEKISIIIPVYNVKKYLNDCIQSVINQTYNNLEIILIDDGSTDGS FT GDYCDEIAKKDSRIFVYHKTNGGLSEARNVGIKISTGKYITFIDSDDYIENLYIETLYN FT SLIEYKADIAIVNKYHLKDNEKIVHLANSKELFRVFDTKMILESMYSRENNFISTLTMA FT QLKLYRKELFSDIEFPIGKKYEDSFTTYKTYIEANRIVFVNRPLYAYRFRSGSITRSGY FT QLSNLDVLEMYEERLEYFRERGYDLLSTKYHYCIAIANQKELLKKHFPNNPKIYKLDSQ FT FREIYCDILNELPFKKRIKLGIIRFLPFIKRLKYQFIESR" FT gene 5452..6315 FT /gene="cps2P" FT CDS 5452..6315 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2P" FT /product="putative glycosyl transferase" FT /db_xref="GOA:A8JZW1" FT /db_xref="InterPro:IPR003406" FT /db_xref="UniProtKB/TrEMBL:A8JZW1" FT /protein_id="ABV59024.1" FT /translation="MQHILAIISYKMTHALKCTVDLLKNDMDIVIHVDAKSDIKQYDSI FT KEFVTFTEERIDVRWGHYSQILAMLVLLKYMKSKEKYHYISIISESDIPLKTGKEINTF FT LTLHKGKEFIGMVSNEQMSDFEYDKLKYNYPDFCFSKRGIFKKIYRGTKVYRFFKNARY FT YSLPPLRKGSQWFTISREFTDWIIGYLDKHPDYQEAFCHSYCGDELFFQTLLAISPFQE FT RVMNNKDDCLMGGRYIIWEADKTSPCDLFAEKVLEYRKEAESALFFRKVSEESDFDVYM FT HLLNKL" FT gene 6331..7284 FT /gene="cps2Q" FT CDS 6331..7284 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2Q" FT /product="putative glycosyl transferase" FT /db_xref="GOA:A3KLL0" FT /db_xref="UniProtKB/TrEMBL:A3KLL0" FT /protein_id="ABV59025.1" FT /translation="MKLLFIVPYFGKFNSYFQLFLNSIATSDLCDLLIVTDDKSKYDYP FT QNVTIRYTSFEEFRNEVQRKMDFKITLDTPYKLCDFKPTYGYLFEDELLNYQYWGYCDL FT DIIFGDLDGFLHPILNKGFDKIFELGHCTIIKNESRINRMFLSTVNGVKIGQKALSSSK FT IEVFDEAYVNSINNIFIENNCNNFLYSLGADIDIWKNNFYITSFKNKKDFVVSDAPSIF FT YYEQGHLYEFHQYKSVVRRSEYLYIHLQQRKMKVDLDARSTTYLILPNKFVEYRIATNC FT LLTLKEFKRFISFGKYSFQKYRLYTKLQKQKIKKLL" FT gene 7292..8221 FT /gene="cps2K" FT CDS 7292..8221 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2K" FT /product="alpha-2,3-N-acetylneuraminyl transferase" FT /db_xref="GOA:A8JZX7" FT /db_xref="InterPro:IPR008666" FT /db_xref="UniProtKB/TrEMBL:A8JZX7" FT /protein_id="ABV59026.1" FT /translation="MKMKNIYICYTLYHLLISLCKRDLFGKIIILTTRINNYAIYKRRI FT EKLFPEIPVLIVDDSDYSKKYKLFYPKRIKQELFSITNGNKIHIYNDYTQLGYFFHRNA FT IPYHLMEDGYNSLKHPTSIAPDGLCDKIKGKITNTPRYHGFSKYCKTIEVSSLKDLPTD FT ERMSKFIEKPKDGLFSDLDNKTKESILKIFDIASIDIEIASPSALILTQPLEEHFKSQE FT EIYQFYKSIVEEYIDKGYHIYIKVHPRDNIDYSNLNATVIQRNIPIELFDFLENIKFDV FT GITYFSTALDFLNCVNKKIFLYNIKDIK" FT gene 8218..9618 FT /gene="cps2L" FT CDS 8218..9618 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2L" FT /product="capsular polysaccharide repeat unit transporter" FT /db_xref="GOA:Q67AZ0" FT /db_xref="InterPro:IPR002797" FT /db_xref="UniProtKB/TrEMBL:Q67AZ0" FT /protein_id="ABV59027.1" FT /translation="MNTKKLLQSGFIYTLGNLLVQGLAFITLPIYTRVISTEVYGQYSL FT YVAWMNIIMLFIGLQTSGSLSSARVKYGEEFKSYSGSAFSVGNIWFLIILLIAFLFRSF FT LAPLVGFSESIFLLMVCQSYASYVVTFFGQYFIQQQRSLANLILSLANAVSSVALSLFL FT IFHWSDDFLSRVLGAFVPTIITGIVAFAYIYYHSKSFYNPKYFRFIVTVSIPLIFHLLG FT HQLLNQLDRIMLVRLYSTKEVAMYSFGYSLGMIIQIVLNSINMAWIPWFFDARKEKLLQ FT LSTYISRYLYLGVFLTLGYLTVFPELAQIMGGDKYSSSVQFISLIIVSYFLVFLYTFPV FT NIQFFYANTTWIPIGTLLAAGVNWLLNLVLIPHYAAYGAAMATIISYLALLIFHHIVSK FT VKYHYSDVSVRQYIILSGIVFSYAMLMNMFLDNIVIRWSLGIIILIVYSIVFQKVILDL FT LSKKRRRR" FT gene 9618..10643 FT /gene="neuB" FT CDS 9618..10643 FT /codon_start=1 FT /transl_table=11 FT /gene="neuB" FT /product="N-acetylneuraminic acid synthetase" FT /db_xref="GOA:A8JZX9" FT /db_xref="InterPro:IPR020007" FT /db_xref="UniProtKB/TrEMBL:A8JZX9" FT /protein_id="ABV59028.1" FT /translation="MVYIIAEIGCNHNGDINLAKKMVDVAVSCGVDAVKFQTFKAEKLI FT SKFAPKAEYQKATTGTADSQLEMTKRLELSFEEYLEMRDYAISKGVETFSTPFDEESLE FT FLISTDMPIYKIPSGEITNLPYLEKIGKQQKKVLLSTGMAVMEEIHQAVNILRQNGTTD FT ISILHCTTEYPTPYPSLNLNVIHTLKNEFKDLTIGYSDHSIGSEVPIAAAAMGAEVIEK FT HFTLDTNMEGPDHKASATPDILAALVKGVRIVEQALGRFEKIPDPVEEKNKIVARKSVV FT ALKPIKKGDIYSIENITVKRPGNGISPMNWYDILGQEAQDDFEEDEVIRDSRFENQLPE FT L" FT gene 10720..11874 FT /gene="neuC" FT CDS 10720..11874 FT /codon_start=1 FT /transl_table=11 FT /gene="neuC" FT /product="N-acetylglucosamine-2-epimerase" FT /db_xref="GOA:Q67A28" FT /db_xref="InterPro:IPR020004" FT /db_xref="UniProtKB/TrEMBL:Q67A28" FT /protein_id="ABV59029.1" FT /translation="MKKICLVTGSRAEYGIMKPLIQRLSKDKEVNLQIIATAMHLEEKY FT GYTYRQIEEDGFDIAYKVPLHLYDTDRRTVSTAMAHLQLGLTKIFDKEDYDLVIILGDR FT YEMLPVVNVALIYNVPVCHLHGGETSLGNFDEYIRHAITKMSHLHLVSTEDFRQRVIQM FT GEQPQFVINTGALGVENALSIPSLTKEAIEKQLGIVLEESYFVVLYHPVTFEQGKSAGE FT QMKAVLSALSKFGVQCLFIGSNSDTGSDDIAKAINTYLINHENSYCFASLSTQLYHSLI FT RHSLGLIGNSSSGLIEVPSLMKPTLNIGDRQKGRLHGESVVSVPVETSSVLEGLSKLNE FT VTNFDNPYYKGNASSIAYEAIKLYLKDEPSISQPFYDLKENNLK" FT gene 11871..12500 FT /gene="neuD" FT CDS 11871..12500 FT /codon_start=1 FT /transl_table=11 FT /gene="neuD" FT /product="putative acetyl transferase" FT /db_xref="GOA:A8JZY1" FT /db_xref="InterPro:IPR020019" FT /db_xref="UniProtKB/TrEMBL:A8JZY1" FT /protein_id="ABV59030.1" FT /translation="MKKKLAFLGAGSHADAIAPVIDPLVYDFVGFFDDKDITEHDGYPV FT LGKLYDVLPYLEDGSIDAVFITIGDNTKRKELFEYVAKDYYDFIINIISPNALVLTPDS FT ICGRGIFIGFGAFIGSKVKLFDNNVVNTGALIEHHTVVESHCNIAPNATINGLCYIREE FT VYVGSASVIIQTLDISSCTTIGAGAVVVKDIIEPGTYVGVPAKKIK" FT gene 12511..>12864 FT /gene="neuA" FT CDS 12511..>12864 FT /codon_start=1 FT /transl_table=11 FT /gene="neuA" FT /product="CMP-N-acetylneuraminic acid synthetase" FT /db_xref="GOA:A8JZW8" FT /db_xref="InterPro:IPR003329" FT /db_xref="UniProtKB/TrEMBL:A8JZW8" FT /protein_id="ABV59031.1" FT /translation="MKPICIIPARSGSKGLPDKNMLFLAGKPMIFHTIDAAIESGMFDK FT KDIFVSTDSELYREICLERGISVVMRKPELSTDQATSYDMLKDFLSDYEDNQEFVLLQV FT TSPLRKSWHIKEAM" XX SQ Sequence 12864 BP; 4455 A; 1684 C; 2247 G; 4478 T; 0 other; attatggaaa ttacggaaaa agggatagaa aaaggaagta aggggctctt gtattgaaag 60 aaaaagaaaa tatacaaaag attattatag cgatgattca aacagttgtg gtttattttt 120 ctgcaagttt gacattaaca ttaattactc ccaattttaa aagcaataaa gatttattgt 180 ttgttctatt gatacattat attgtctttt atctttctga tttttataga gacttttgga 240 gtcgtggcta tcttgaagag tttaaaatgg tattgaaata cagcttttac tatattttca 300 tatcaagttc attatttttt atttttaaaa actcttttac aacgacacga ctttcctttt 360 ttacttttat tgctatgaat tcgattttat tatatctatt gaattcattt ttaaaatatt 420 atcgaaaata ttcttacgct aagttttcac gagataccaa agttgttttg ataacgaata 480 aggattcttt atcaaaaatg acctttaaga ataaatacga ccataattat atcgctgtct 540 gtatcttgga ctcctctgaa aaggattgtt atgatttgaa acataactcg ttaaggataa 600 taaacaaaga tgctcttact tcagagttaa cctgcttaac tgttgatcaa gcttttatta 660 acatacccat tgaattattt ggtaaatacc aaatacaaga tattattaat gacattgaag 720 caatgggagt gattgtcaat gttaatgtag aggcacttag ctttgataat ataggagaaa 780 agcgaatcca aacttttgaa ggatatagtg ttattacata ttctatgaaa ttctataaat 840 atagtcacct tatagcaaaa cgatttttgg atatcatggg tgctattata ggtttgctca 900 tatgtggcat tgtggcaatt tttctagttc cgcaaatcag aaaagatggt ggaccggcta 960 tcttttctca aaatagagta ggtcgtaatg gtaggatttt tagattctat aaattcagat 1020 caatgcgagt agatgcagaa caaattaaga aagatttatt agttcacaat caaatgacgg 1080 ggctaatgtt taagttagac gatgatccta gaattactaa aataggaaaa tttattcgaa 1140 aaacaagcat agatgagttg cctcaattct ataatgtttt aaaaggtgat atgagtttag 1200 taggaacacg ccctcccaca gttgatgaat atgaaaagta taattcaacg cagaagcgac 1260 gccttagttt taagccagga atcactggtt tgtggcaaat atctggtaga aataatatta 1320 ctgattttga tgaaatcgta aagttagatg ttcaatatat caatgaatgg tctatttggt 1380 cagatattaa gattattctc ctaacactaa aggtagtctt acttgggaca ggagctaagt 1440 aaaggtaagg tttgaaagga atataatgaa aatttgtctg gttggttcaa gtggtggtca 1500 tctagcacac ttgaaccttt tgaaacccat ttgggaaaaa gaagataggt tttgggtaac 1560 ctttgataaa gaagatgcta ggagtattct aagagaagag attgtatatc attgcttctt 1620 tccaacaaac cgtaatgtca aaaacttggt aaaaaatact attctagctt ttaaggtcct 1680 tagaaaagaa agaccagatg ttatcatatc atctggtgcc gctgtagcag taccattctt 1740 ttatattggt aagttatttg gttgtaagac cgtttatata gaggttttcg acaggataga 1800 taaaccaact ttgacaggaa aattagtgta tcctgtaaca gataaattta ttgttcagtg 1860 ggaagaaatg aaaaaagttt atcctaaggc aattaattta ggaggaattt tttaatgatt 1920 tttgtcacag tggggacaca tgaacagcag ttcaaccgtc ttattaaaga agttgataga 1980 ttaaaaggga caggtgctat tgatcaagaa gtgttcattc aaacgggtta ctcagacttt 2040 gaacctcaga attgtcagtg gtcaaaattt ctctcatatg atgatatgaa ctcttacatg 2100 aaagaagctg agattgttat cacacatggc ggcccagcga cgtttatgaa tgcagtttct 2160 aaaggaaaaa aaactattgt ggtacctaga caagaacagt ttggagagca tgtgaataat 2220 catcaggtgg attttgttaa taaggtaaaa acaatgtata attttgatat cgttgtagat 2280 attgaaaggt tacaaaatgt agtctatgag gggacgatga atcgtccgtt tttagaaact 2340 aacagaagta attttattga agaatttaag gtaatattaa aggagttgtg tgatgaaaat 2400 caataaaaat aaaaattatt tttttgaagt aatttttatc atactttttt ctctattagc 2460 tctatataca ggtgtttaca gggacggaaa ttatctttat gactatcttt ttttacttta 2520 tgctttttat gcatttctga ggtcaatcac aattacttat tctagaaaag aaataataat 2580 tttaataagt gtaacaattc tttttgttct aaatagtttt ttttcaaaag gtaatagttg 2640 gctttctatt ttgataatat tattagggag taggaagata gctattgata ggattataga 2700 tagtttatta atatgtaaga ttatttcatt tataggcgtt ttaacatttg taaaccttca 2760 tattttagaa aataagcaag ttctcacata tagatatggt gaagtagtag caaggtatgc 2820 atatggattt aatcatccca ataccttaca tgcctttttc tttataataa taatgctatt 2880 tatctaccgt ttctttacta aattaaagta tcttcattta gtaatcattt taattattaa 2940 tcagtatatt tattctattt cagttgctag aacaggttat tttttagtaa tatttgcagt 3000 agtattttac attattctac gaaataattt tttgatacag caaataactt ttaaaatagc 3060 accgtatgta cagtttattg cgatgtttag tttgttatta ttttctttat ttttctttaa 3120 tactcctatt gtttcaaaat tagataacct tttaagtggt agaatttatt acgcgaagct 3180 tatcttaaca gattcactta atttatttgg aaatgaaatc aactatttta ttgatagata 3240 tattttattt tttcatgata acagttattc ttcaacactt gcactaagtg gaattattat 3300 tacatttggg tatatgtact tatattttaa aacctctcga aagttagtgc aggatcataa 3360 tattgctgct ttatatttat ttgtttcaaa ttccttgtta ttttactccg aagattatat 3420 acgcgagcca tttttaaata ttactttatt ttttataggt aaatatatat ttaatgaatt 3480 aggagagata aatgagtgat aaattttcaa ataaaatcag tgttatagtt cctttatata 3540 atgtagagaa atatatcata aattgtattt cttcacttac gaatcaaact tatcagaata 3600 tagaaattat tttgatagat gatggttcta ctgataatag tggtaggata tgcaaaaaat 3660 tagctcaaga ggatcatcgt attatttatt taaggaaaga aaatggtggg gtttctagtg 3720 ctcgaaattt agggctacaa tatgcaacag gaagttacat tggttttgta gactcagatg 3780 actatatatc aaaaacaatg tatgaaaact tattaaagag attattagaa actaatgcag 3840 atatcgccga aactgacttt gccttaattg ataatagatt tacgaaaaaa aagaggaaaa 3900 agatacagaa agttctgaat aaagaagaag ctattaggga gtttttatca ggaaatgtgg 3960 ttgaaaataa tctcgtcata aagttattta aaaaaacagt tattgctaat ctaaaattta 4020 aagaagatgt gatagttggt gaagatatgc tattttcttt gcaggcctta ctaaactcag 4080 atagagttac agtggacact acgaatgcgg attattttta tgtcgtacgt tcaaattcaa 4140 ctatgaatac tattaccgag aaggatatcg ataatctttc aatactcgag caggagttca 4200 aaaaaattga tatcccccaa ttaaaaagtt atttggaagc caaattaatt cgagaaaagg 4260 ttaaatttgt atctagagta ttaattagta ataaagcaca tttgtacagt gatattattg 4320 atagatattt gcaagaggtt agacactaca gcataaaaaa tatgataaac tttctttcgt 4380 cgaaacattg tttgactata actattatga aaatatcacc taaactatat acacttttat 4440 ataaagtttt tcaaaagcaa taaatatcgg aacggaggct tttattggaa aagattagta 4500 ttattatacc ggtatacaat gttaagaagt atcttaatga ttgtattcaa tctgttataa 4560 accagactta caataattta gagattattt taattgatga tggttctacc gatggttcag 4620 gagactattg tgatgaaatt gccaaaaaag atagtcgaat ttttgtgtat cataagacaa 4680 acggcggtct atcagaagct cgaaacgttg gaataaaaat aagtaccggg aaatatatta 4740 catttataga ttcagacgat tacatcgaaa atttatatat tgaaacttta tacaacagtt 4800 taattgagta taaggctgat attgctattg ttaataaata tcatttaaag gataacgaga 4860 aaattgttca tttggcaaat tccaaagaac tttttagggt atttgatact aaaatgattt 4920 tagagagtat gtatagtaga gagaataatt ttattagtac cctgacaatg gcgcagctaa 4980 aattatatcg taaggaactt ttctctgata tagaatttcc cattgggaaa aaatatgaag 5040 attcttttac aacttataag acatacattg aagctaatag gattgttttt gttaatagac 5100 cattatatgc ctatcgattt cgaagtggga gcattacaag aagtggttat caattatcaa 5160 atttagacgt tttagaaatg tacgaagagc ggttggaata ttttagagaa agaggatatg 5220 atttacttag tactaaatat cattattgta tagctattgc aaatcaaaaa gagttattaa 5280 aaaaacattt ccctaataat cctaaaattt ataaattgga cagccagttt agagaaatat 5340 attgtgatat tttaaatgaa cttcccttta aaaagcgaat aaaattagga attattaggt 5400 tcttaccatt tattaaacgg ttaaaatacc aatttattga aagtagatga tatgcaacat 5460 atattagcaa ttattagtta taaaatgaca catgcattaa aatgtaccgt agatttattg 5520 aaaaatgata tggatatagt tatacacgtt gatgccaaaa gtgatataaa acaatatgat 5580 tcgataaaag aatttgtaac tttcacagaa gaaagaatag atgttcgttg gggacactat 5640 tctcagattt tagctatgtt agttctttta aaatatatga agtccaaaga aaaatatcat 5700 tatatttcta ttattagtga aagcgacatc ccattaaaaa caggtaaaga aattaatact 5760 tttttaaccc ttcataaagg taaagaattc ataggtatgg tttctaacga gcaaatgagt 5820 gattttgagt atgataaact caagtataac tatcctgatt tttgtttttc taaaagagga 5880 atatttaaaa aaatttatag aggtaccaaa gtttataggt tctttaaaaa tgcaaggtat 5940 tattccctac ctcctcttcg taagggaagt cagtggttta ctatttcaag agagtttact 6000 gactggatta ttggatattt agataaacac ccagattatc aggaggcttt ttgtcatagc 6060 tattgtggag atgaattatt ttttcaaaca ttactagcta tctctccatt tcaagaaagg 6120 gtgatgaata ataaagatga ctgtctcatg ggagggagat atattatttg ggaggctgat 6180 aagacatcac cttgcgattt atttgctgaa aaagtgttag aatataggaa agaagctgag 6240 agtgctttat tctttagaaa agtatctgaa gaaagcgatt ttgatgttta tatgcatcta 6300 ttaaataaac tttaaattaa ggagaaaata ttgaaacttt tatttattgt tccatatttt 6360 ggaaaattta atagttattt tcagttattt ttaaactcaa tagccacatc agatctttgt 6420 gatttattga ttgttaccga tgataaaagt aaatacgatt accctcagaa tgttactatt 6480 cgctatacta gttttgaaga gttccgaaat gaagtccaaa gaaaaatgga ttttaaaatt 6540 actttagata ctccatacaa actctgtgat tttaaaccaa catacggtta tctatttgaa 6600 gatgaattgt taaattatca atattggggt tattgtgact tagatattat ctttggtgat 6660 ttagatggat ttttacatcc catactaaat aaaggctttg ataaaatttt tgagctaggt 6720 cattgtacga ttattaagaa tgaatcacga ataaatcgaa tgttcctttc tacagttaat 6780 ggggtgaaaa taggacaaaa agctctaagt tcttccaaaa tcgaagtttt tgatgaggca 6840 tatgttaata gtattaataa tatatttatt gaaaataatt gtaataactt tttgtacagt 6900 ttaggagcag acatagatat ttggaagaat aatttttata ttacttcttt caagaataaa 6960 aaagattttg tagtatcaga cgctcccagc atattttact atgaacaagg acacttatat 7020 gagtttcacc aatataagtc tgtagtaaga aggagtgagt atttatatat tcatcttcaa 7080 caaagaaaaa tgaaagttga tttagatgct aggtctacaa cttatctgat attaccaaat 7140 aagttcgtag aatatagaat agctacaaat tgcttgttaa cacttaaaga atttaaacgg 7200 tttattagtt ttggaaaata tagctttcaa aaataccgcc tatatactaa attacaaaag 7260 caaaaaataa agaagttatt atgagatttt aatgaaaatg aagaatattt atatatgtta 7320 cactttatat cacctattga tatctttatg taagagagat ttatttggaa aaataattat 7380 cttaactact cgaataaata attatgcaat atataaaaga agaatagaaa agttgtttcc 7440 agaaatacct gtattgattg tagatgatag tgattacagt aagaaatata aattgtttta 7500 tccgaagcga ataaaacaag aattgtttag tataaccaac ggcaataaaa tacatattta 7560 caatgactat acgcaattag gatatttttt tcataggaat gctattccct accatttaat 7620 ggaagatgga tataatagtt taaaacatcc aacgagtatc gctccagatg gtctttgtga 7680 caagataaaa gggaagataa cgaatacacc ccgatatcat ggcttcagta agtattgtaa 7740 gacgatagaa gtaagtagtt tgaaagattt accaacagat gagagaatgt ctaagtttat 7800 tgagaagccc aaggatggat tattttctga tttagataat aaaactaagg aatctatttt 7860 aaagattttt gacatagcct caatagatat tgaaatagct tctccatctg ctctaatatt 7920 aactcaacct ttagaggaac attttaaaag tcaagaggaa atataccaat tttacaaaag 7980 catagtggaa gaatatattg ataaaggtta ccacatatat attaaagttc accctagaga 8040 taacattgac tactctaatc tcaatgcaac agtaatacaa aggaacatcc ctatagaatt 8100 atttgatttc ctagagaata taaaatttga tgttgggatt acatattttt ccacggcatt 8160 agatttttta aattgtgtta ataaaaaaat tttcttatac aatattaagg atattaaatg 8220 aatactaaga aattacttca atctggtttt atttatacac tcgggaattt attggtgcaa 8280 ggattagcct ttatcacact tcccatctac actcgggtca tctcaacaga agtttatggc 8340 caatatagtt tatatgtcgc ttggatgaat attattatgc tttttattgg ccttcagacg 8400 agcggttctt taagttcagc ccgggtcaaa tacggagaag aatttaaaag ctattctggg 8460 agtgcctttt ctgtaggtaa tatatggttt cttattatac ttttgatagc ttttctattt 8520 agaagttttc ttgcaccatt agttggtttt tctgaatcta tttttttatt aatggtgtgt 8580 caaagttacg ctagctatgt ggtgactttc tttggtcagt attttataca acaacagagg 8640 agtttggcta atttaatatt atccttagcc aatgcagttt catctgttgc actatctcta 8700 tttttaattt ttcattggtc cgatgacttt ttatctaggg ttttgggagc ttttgttcct 8760 actataataa ctggaatagt tgcctttgct tatatttatt atcatagcaa atctttttac 8820 aatcctaagt attttcggtt cattgtcact gtgtctattc ctttgatttt tcatttgtta 8880 ggacatcagt tattaaatca attagatagg attatgctag ttcgcttata tagtactaaa 8940 gaagttgcaa tgtatagttt cggttattcg cttggaatga ttattcagat tgttttgaat 9000 agtattaata tggcttggat tccatggttt tttgatgcta gaaaagaaaa attactgcaa 9060 ctttcaactt atattagccg ttatctctat ttaggagttt tcttaacatt aggttatttg 9120 actgtttttc ctgagttagc tcaaataatg ggaggagaca agtatagtag tagtgttcaa 9180 tttatttctt taattattgt cagctacttt ttagtctttc tctatacatt tcctgtaaat 9240 atccaattct tctatgctaa tacgacatgg attcctattg ggacattatt agctgctggt 9300 gtaaattggt tactaaacct tgtattaatt cctcattatg cagcctatgg cgctgctatg 9360 gctacaataa tatcttattt agccttgttg atttttcatc atattgtttc gaaagttaaa 9420 taccattatt cagatgtctc agttaggcag tacatcattt taagtggtat agtatttagt 9480 tatgctatgt taatgaacat gttcctagat aatatcgtta ttagatggag tttaggaata 9540 attattctta tagtatatag cattgttttt caaaaagtca ttttagactt attgagtaaa 9600 aaaagaagga gaagataatg gtttatatta ttgcagagat tggttgcaat cataatggag 9660 atattaatct tgcgaaaaaa atggtagatg ttgccgtgtc ttgtggtgtt gatgctgtta 9720 aatttcagac ttttaaagct gagaaactta tttctaaatt tgctcccaaa gctgaatatc 9780 aaaaagcaac tacaggaaca gcagacagtc aacttgagat gacgaaacgt ttagagttaa 9840 gctttgaaga atacttagaa atgcgtgatt atgcaatttc aaaaggtgtg gagacctttt 9900 caacaccttt tgatgaagag tcattagagt tcttaatttc tacagatatg ccaatttaca 9960 aaattccatc aggagaaatc actaatttac cttacttaga aaagattggc aagcaacaaa 10020 agaaagttct tctttcgacg ggtatggcgg taatggaaga gatccatcaa gcggtgaata 10080 ttttacgtca gaatggtaca accgacattt ctattttaca ttgtacaaca gagtacccaa 10140 caccttaccc ctctctaaat ttaaatgtta ttcatacttt gaaaaatgaa tttaaagatt 10200 taacgatagg ttattcggat cattcaattg gatcagaagt acctatcgca gcagcagcaa 10260 tgggtgcaga agttattgaa aaacacttta ctttagatac taatatggaa ggtccggatc 10320 ataaagccag tgcaacacct gatattttag ctgctttagt taaaggggtt cgcattgttg 10380 aacaagcctt aggtagattt gaaaaaatcc cagatccagt agaagagaaa aataagattg 10440 ttgctcgtaa atcagtcgtt gctttaaaac caattaaaaa aggcgatatt tattcaatag 10500 aaaatattac ggtgaagcgc ccaggtaatg gtatttctcc tatgaactgg tatgacatct 10560 tgggacaaga agcgcaagat gatttcgaag aggatgaagt tattcgtgat tcacgctttg 10620 aaaatcaatt gcccgagtta taataacacc taattataat cggcaacaga tgtattacac 10680 ggctaagatt atgtaattac tatatataga agggatacga tgaaaaaaat ttgtttagta 10740 accggatcgc gtgctgaata cggaataatg aagccattga ttcaaagatt atcaaaagat 10800 aaagaagtca acttacaaat tattgcaaca gcaatgcatc tggaagaaaa atacggctat 10860 acttatcgtc aaattgaaga agacggtttt gatattgctt ataaagttcc cttacatctt 10920 tatgatactg acagaagaac tgtatctact gcaatggcgc atttacaact aggattgacc 10980 aaaatttttg acaaggaaga ctatgatcta gtcatcattt taggggatcg ttacgaaatg 11040 ttaccagttg tgaatgtagc gttgatttat aatgtcccag tatgccacct tcatggaggg 11100 gagacctcat taggcaattt tgatgagtat attcgccatg caattactaa gatgagtcac 11160 ctacacttag tctctacaga ggactttcgt caacgtgtga ttcagatggg agaacaacct 11220 caatttgtaa ttaacacagg agctctcgga gtggaaaatg ctctatcaat cccttctcta 11280 accaaagaag caatagaaaa gcaattaggt attgtactag aggaatccta ttttgttgtt 11340 ctctatcatc ctgttacttt tgaacaagga aaaagtgctg gagaacagat gaaagcggta 11400 ctatcagccc tttctaaatt tggtgtccag tgtctattta taggatccaa ttcagatact 11460 ggttctgatg atattgcaaa ggctatcaat acttatttga taaatcatga aaatagttat 11520 tgctttgctt ctttatcaac ccaactttat cattccttaa ttcgtcattc actaggactg 11580 attggtaatt cgtcttctgg tttaatagaa gttccttctt tgatgaaacc tactcttaat 11640 attggtgatc gccaaaaagg taggctacat ggagaaagtg tagtaagtgt accagtcgaa 11700 acctcctctg tattggaggg attatcaaaa ttgaatgaag tgaccaactt tgacaatccc 11760 tactacaaag ggaatgcttc atctattgca tatgaagcaa taaagcttta tttgaaagat 11820 gaaccttcaa tttcccaacc attttatgat ttaaaggaga ataatctaaa atgaaaaaaa 11880 agttggcatt tttaggcgca ggaagtcatg ctgatgcgat tgctccggtt attgatcctc 11940 ttgtgtatga tttcgtaggt ttttttgatg ataaagatat tacggagcat gatggttatc 12000 ctgttcttgg aaaactttat gatgtgctac cttaccttga agatggctca atagatgcag 12060 tatttattac aataggtgat aatactaaaa ggaaagaact atttgaatat gtagcaaagg 12120 attattatga ctttattatt aacatcatta gtcccaatgc tttagtattg acaccagata 12180 gtatttgtgg acgtggtatc tttattggtt ttggggcttt tataggttct aaagtgaagc 12240 tgtttgataa taacgttgtt aatacaggag cgctcattga acatcatact gttgtagaat 12300 cacactgtaa tatagcacct aatgctacca taaatggtct ttgttatatt agagaagaag 12360 tttatgtagg tagtgccagt gttattattc aaaccttgga tatttcatcg tgtacgacaa 12420 ttggagcagg agctgttgtt gtaaaagata ttatagaacc tggaacctat gtaggggttc 12480 cagccaaaaa aataaaataa aggatatgtt atgaagccaa tttgtattat tcctgcgcga 12540 tcagggtcaa aaggattacc agataagaat atgttattcc tagcaggtaa acccatgatt 12600 ttccatacta tagatgctgc aattgaatct ggaatgtttg ataagaaaga tatttttgtt 12660 agtacagatt cagaattgta cagagagatt tgtttagaac gcggtatttc agtggtgatg 12720 agaaaaccgg aactttcaac tgatcaggca acttcgtatg atatgttaaa agatttttta 12780 tctgactatg aagataatca ggagtttgtg ttacttcaag taacttctcc actaagaaaa 12840 tcatggcata taaaggaagc aatg 12864 // |
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