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EBI DbfetchID EF990364; SV 1; linear; genomic DNA; STD; PRO; 12958 BP. XX AC EF990364; XX DT 06-OCT-2007 (Rel. 93, Created) DT 06-OCT-2007 (Rel. 93, Last updated, Version 1) XX DE Streptococcus agalactiae strain 318905 capsular polysaccharide synthesis DE gene locus, complete sequence. XX KW . XX OS Streptococcus agalactiae OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus. XX RN [1] RP 1-12958 RX DOI; 10.1128/JCM.01296-07 RX PUBMED; 17715372. RA Martins E.R., Melo-Cristino J., Ramirez M.; RT "Reevaluating the serotype II capsular locus of Streptococcus agalactiae"; RL J. Clin. Microbiol. 45(10):3384-3386(2007). XX RN [2] RP 1-12958 RA Martins E., Ramirez M., Melo-Cristino J.; RT ; RL Submitted (22-JUN-2007) to the EMBL/GenBank/DDBJ databases. RL Molecular Microbiology and Infection Unit, Institute of Molecular Medicine, RL Av. Prof. Egas Moniz, Lisbon 1649-028, Portugal XX FH Key Location/Qualifiers FH FT source 1..12958 FT /organism="Streptococcus agalactiae" FT /strain="318905" FT /serotype="II" FT /mol_type="genomic DNA" FT /db_xref="taxon:1311" FT misc_feature 1..12958 FT /note="capsular polysaccharide synthesis gene locus" FT gene 187..1536 FT /gene="cps2E" FT CDS 187..1536 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2E" FT /product="glycosyl transferase" FT /db_xref="GOA:Q8VLF7" FT /db_xref="InterPro:IPR003362" FT /db_xref="InterPro:IPR017475" FT /db_xref="UniProtKB/TrEMBL:Q8VLF7" FT /protein_id="ABV59004.1" FT /translation="MIQTVVVYFSASLTLTLITPNFKSNKDLLFVLLIHYIVFYLSDFY FT RDFWSRGYLEEFKMVLKYSFYYIFISSSLFFIFKNSFTTTRLSFFPFIAMNSILLYLLN FT SFLKYYRKYSYAKFSRDTKVVLITNKDSLSKMTFKNKYDHNYIAVCILDSSEKDCYDLK FT HNSLRIINKDALTSELTCLTVDQAFINIPIELFGKYQIQDIINDIEAMGVIVNVNVEAL FT SFDNIGEKRIQTFEGYSVITYSMKFYKYSHLIAKRFLDIMGAIIGLLICGIVAIFLVPQ FT IRKDGGPAIFSQNRVGRNGRIFRFYKFRSMRVDAEQIKKDLLVHNQMTGLMFKLDDDPR FT ITKIGKFIRKTSIDELPQFYNVLKGDMSLVGTRPPTVDEYEKYNSTQKRRLSFKPGITG FT LWQISGRNNITDFDEIVKLDVQYINEWSIWSDIKIILLTLKVVLLGTGAK" FT gene 1560..2009 FT /gene="cps2F" FT CDS 1560..2009 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2F" FT /product="beta-1,4-galactosyl transferase enhancer" FT /db_xref="GOA:Q9RPC6" FT /db_xref="InterPro:IPR013969" FT /db_xref="UniProtKB/TrEMBL:Q9RPC6" FT /protein_id="ABV59005.1" FT /translation="MKICLVGSSGGHLAHLNLLKPIWEKEDRFWVTFDKEDARSILREE FT IVYHCFFPTNRNVKNLVKNTILAFKVLRKERPDVIISSGAAVAVPFFYIGKLFGCKTVY FT IEVFDRIDKPTLTGKLVYPVTDKFIVQWEEMKKVYPKAINLGGIF" FT gene 2009..2500 FT /gene="cps2G" FT CDS 2009..2500 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2G" FT /product="beta-1,4-galactosyl transferase" FT /db_xref="GOA:A3KLK5" FT /db_xref="InterPro:IPR007235" FT /db_xref="UniProtKB/TrEMBL:A3KLK5" FT /protein_id="ABV59006.1" FT /translation="MIFVTVGTHEQQFNRLIKEVDRLKGTGAIDQEVFIQTGYSDFEPQ FT NCQWSKFLSYDDMNSYMKEAEIVITHGGPATFMNAVSKGKKTIVAPRQEQFGEHVNNHQ FT VDFVNKVKTMYNFDIVVDIERLQNVVYEGTMNRPFLETNRSNFIEEFKVILKELCDENQ FT " FT gene 2484..3593 FT /gene="cps2H" FT CDS 2484..3593 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2H" FT /product="CPS polymerase" FT /db_xref="UniProtKB/TrEMBL:A8JZV8" FT /protein_id="ABV59007.1" FT /translation="MMKINKNKNYFFEVIFIILFSLLALYTGVYRDGNYLYDYLFLLYA FT FYAFLRSITITYSRKEIIILISVTILFVLNSFFSKGNSWLSILIILLGSRKIAIDRIID FT SLLICKIISFIGVLTFVNLHILENKQVLTYRYGEVVARYAYGFNHPNTLHAFFFIIIML FT FIYRFFTKLKYLHLVIILIINQYIYSISVARTGYFLVIFAVVFYIILRNNFLIQQVTFK FT IAPYVQFIAMFSLLLFSLFFFNTPIVSKLDNLLSGRIYYAKLILTDSLNLFGNEINYFI FT DRYILFFHDNSYSSTLALSGIIITFGYMYLYFKTSRKLVQDHNIAALYLFVSNSLLFYS FT EDYIREPFLNITLFFIGKYIFNELGEINE" FT gene 3586..4557 FT /gene="cps2I" FT CDS 3586..4557 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2I" FT /product="beta-1,3-N-acetylglucosaminyl transferase" FT /db_xref="GOA:A3KLK7" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:A3KLK7" FT /protein_id="ABV59008.1" FT /translation="MSDKFSNKISVIVPLYNVEKYIINCISSLTNQTYQNIEIILIDDG FT STDNSGRICKKLAQEDHRIIYLRKENGGVSSARNLGLQYATGSYIGFVDSDDYISKTMY FT ENLLKRLLETNADIAETDFALIDNRFTKKKRKKIQKVLNKEEAIREFLSGNVVENNLVI FT KLFKKTVIANLKFKEDVIVGEDMLFSLQALQNSDRVTVDTTNADYFYVVRSNSTMNTIT FT EKDIDNLSILEQEFKKIDIPQLKSYLEAKLIREKVKFVSRVLISNKAHLYSDIIDRYLQ FT EVRHYSIKNMINFLSSKHCLTITIMKISPKLYTLLYKVFQKQ" FT gene 4579..5544 FT /gene="cps2J" FT CDS 4579..5544 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2J" FT /product="putative glycosyl transferase" FT /db_xref="GOA:A3KLK8" FT /db_xref="InterPro:IPR001173" FT /db_xref="UniProtKB/TrEMBL:A3KLK8" FT /protein_id="ABV59009.1" FT /translation="MEKISIIIPVYNVKKYLNDCIQSVINQTYNNLEIILIDDGSTDGS FT GDYCDEIAKKDSRIFVYHKTNGGLSEARNVGIKISTGKYITFIDSDDYIENLYIETLYN FT SLIEYKADIAIVNKYHLKDNEKIVHLANSKELFRVFDTKMILESMYSRENNFISTLTMA FT QLKLYRKELFSDIEFPIGKKYEDSFTTYKTYIEANRIVFVNRPLYAYRFRSGSITRSGY FT QLSNLDVLEMYEERLEYFRERGYDLLSTKYHYCIAIANQKELLKKHFPNNPKIYKLDSQ FT FREIYCDILNELPFKKRIKLGIIRFLPFIKRLKYQFIESR" FT gene 5546..6409 FT /gene="cps2P" FT CDS 5546..6409 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2P" FT /product="putative glycosyl transferase" FT /db_xref="GOA:A8JZW1" FT /db_xref="InterPro:IPR003406" FT /db_xref="UniProtKB/TrEMBL:A8JZW1" FT /protein_id="ABV59010.1" FT /translation="MQHILAIISYKMTHALKCTVDLLKNDMDIVIHVDAKSDIKQYDSI FT KEFVTFTEERIDVRWGHYSQILAMLVLLKYMKSKEKYHYISIISESDIPLKTGKEINTF FT LTLHKGKEFIGMVSNEQMSDFEYDKLKYNYPDFCFSKRGIFKKIYRGTKVYRFFKNARY FT YSLPPLRKGSQWFTISREFTDWIIGYLDKHPDYQEAFCHSYCGDELFFQTLLAISPFQE FT RVMNNKDDCLMGGRYIIWEADKTSPCDLFAEKVLEYRKEAESALFFRKVSEESDFDVYM FT HLLNKL" FT gene 6425..7378 FT /gene="cps2Q" FT CDS 6425..7378 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2Q" FT /product="putative glycosyl transferase" FT /db_xref="GOA:A3KLL0" FT /db_xref="UniProtKB/TrEMBL:A3KLL0" FT /protein_id="ABV59011.1" FT /translation="MKLLFIVPYFGKFNSYFQLFLNSIATSDLCDLLIVTDDKSKYDYP FT QNVTIRYTSFEEFRNEVQRKMDFKITLDTPYKLCDFKPTYGYLFEDELLNYQYWGYCDL FT DIIFGDLDGFLHPILNKGFDKIFELGHCTIIKNESRINRMFLSTVNGVKIGQKALSSSK FT IEVFDEAYVNSINNIFIENNCNNFLYSLGADIDIWKNNFYITSFKNKKDFVVSDAPSIF FT YYEQGHLYEFHQYKSVVRRSEYLYIHLQQRKMKVDLDARSTTYLILPNKFVEYRIATNC FT LLTLKEFKRFISFGKYSFQKYRLYTKLQKQKIKKLL" FT gene 7386..8315 FT /gene="cps2K" FT CDS 7386..8315 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2K" FT /product="alpha-2,3-N-acetylneuraminyl transferase" FT /db_xref="GOA:A3KLL1" FT /db_xref="InterPro:IPR008666" FT /db_xref="UniProtKB/TrEMBL:A3KLL1" FT /protein_id="ABV59012.1" FT /translation="MKMKNIYICYTLYHLLISLCKRDLYGKIIILTTRINNYAIYKRRI FT EKLFPEIPVLIVDDSDYSKKYKLFYPKRIKQELFSITNGNKIHIYNDYTQLGYFFHRNA FT IPYHLMEDGYNSLKHPTSIAPDGLCDKIKGKITNTPRYHGFSKYCKTIEVSSLKDLPTD FT ERMSKFIEKPKDGLFSDLDNKTKESILKIFDIASIDIEIASPSALILTQPLEEHFKSQE FT EIYQFYKSIVEEYIDKGYHIYIKVHPRDNIDYSNLNATVIQRNIPIELFDFLENIKFDV FT GITYFSTALDFLNCVNKKIFLYNIKDIK" FT gene 8312..9712 FT /gene="cps2L" FT CDS 8312..9712 FT /codon_start=1 FT /transl_table=11 FT /gene="cps2L" FT /product="capsular polysaccharide repeat unit transporter" FT /db_xref="GOA:Q67AZ0" FT /db_xref="InterPro:IPR002797" FT /db_xref="UniProtKB/TrEMBL:Q67AZ0" FT /protein_id="ABV59013.1" FT /translation="MNTKKLLQSGFIYTLGNLLVQGLAFITLPIYTRVISTEVYGQYSL FT YVAWMNIIMLFIGLQTSGSLSSARVKYGEEFKSYSGSAFSVGNIWFLIILLIAFLFRSF FT LAPLVGFSESIFLLMVCQSYASYVVTFFGQYFIQQQRSLANLILSLANAVSSVALSLFL FT IFHWSDDFLSRVLGAFVPTIITGIVAFAYIYYHSKSFYNPKYFRFIVTVSIPLIFHLLG FT HQLLNQLDRIMLVRLYSTKEVAMYSFGYSLGMIIQIVLNSINMAWIPWFFDARKEKLLQ FT LSTYISRYLYLGVFLTLGYLTVFPELAQIMGGDKYSSSVQFISLIIVSYFLVFLYTFPV FT NIQFFYANTTWIPIGTLLAAGVNWLLNLVLIPHYAAYGAAMATIISYLALLIFHHIVSK FT VKYHYSDVSVRQYIILSGIVFSYAMLMNMFLDNIVIRWSLGIIILIVYSIVFQKVILDL FT LSKKRRRR" FT gene 9712..10737 FT /gene="neuB" FT CDS 9712..10737 FT /codon_start=1 FT /transl_table=11 FT /gene="neuB" FT /product="N-acetylneuraminic acid synthetase" FT /db_xref="GOA:Q9RPC0" FT /db_xref="InterPro:IPR006190" FT /db_xref="InterPro:IPR013132" FT /db_xref="InterPro:IPR013785" FT /db_xref="InterPro:IPR013974" FT /db_xref="InterPro:IPR020007" FT /db_xref="UniProtKB/TrEMBL:Q9RPC0" FT /protein_id="ABV59014.1" FT /translation="MVYIIAEIGCNHNGDINLAKKMVDVAVSCGVDAVKFQTFKAEKLI FT SKFAPKAEYQKATTGTADSQLEMTKRLELSFEEYLEMRDYAISKGVETFSTPFDEESLE FT FLISTDMPIYKIPSGEITNLPYLEKIGKQQKKVILSTGMAVMEEIHQAVNILRQNGTTD FT ISILHCTTEYPTPYPSLNLNVIHTLKDEFKDLTIGYSDHSIGSEVPIAAAAMGAEVIEK FT HFTLDTNMEGPDHKASATPDILAALVKGVRIVEQALGRFEKIPDPVEEKNKIVARKSVV FT ALKPIKKGDIYSIENITVKRPGNGISPMNWYDILGQEAQDDFEEDEVIRDSRFENQLPE FT L" FT gene 10814..11968 FT /gene="neuC" FT CDS 10814..11968 FT /codon_start=1 FT /transl_table=11 FT /gene="neuC" FT /product="N-acetylglucosamine-2-epimerase" FT /db_xref="GOA:Q67A28" FT /db_xref="InterPro:IPR003331" FT /db_xref="InterPro:IPR020004" FT /db_xref="UniProtKB/TrEMBL:Q67A28" FT /protein_id="ABV59015.1" FT /translation="MKKICLVTGSRAEYGIMKPLIQRLSKDKEVNLQIIATAMHLEEKY FT GYTYRQIEEDGFDIAYKVPLHLYDTDRRTVSTAMAHLQLGLTKIFDKEDYDLVIILGDR FT YEMLPVVNVALIYNVPVCHLHGGETSLGNFDEYIRHAITKMSHLHLVSTEDFRQRVIQM FT GEQPQFVINTGALGVENALSIPSLTKEAIEKQLGIVLEESYFVVLYHPVTFEQGKSAGE FT QMKAVLSALSKFGVQCLFIGSNSDTGSDDIAKAINTYLINHENSYCFASLSTQLYHSLI FT RHSLGLIGNSSSGLIEVPSLMKPTLNIGDRQKGRLHGESVVSVPVETSSVLEGLSKLNE FT VTNFDNPYYKGNASSIAYEAIKLYLKDEPSISQPFYDLKENNLK" FT gene 11965..12594 FT /gene="neuD" FT CDS 11965..12594 FT /codon_start=1 FT /transl_table=11 FT /gene="neuD" FT /product="putative acetyl transferase" FT /db_xref="GOA:Q9RPB8" FT /db_xref="InterPro:IPR011004" FT /db_xref="InterPro:IPR020019" FT /db_xref="UniProtKB/TrEMBL:Q9RPB8" FT /protein_id="ABV59016.1" FT /translation="MKKKLAFLGAGSHADAIAPVIDPLVYDFVGFFDDKDITEHDGYPV FT LGKLYDVLPYLEDGSIDAVFITIGDNAKRKELFEYVAKDYYDFIINIISPNALVLTPDS FT ICGRGIFIGFGAFIGSKVKLFDNNVVNTGALIEHHTVVESHCNIAPNATINGLCYIREE FT VYVGSASVIIQTLDISSCTTIGAGAVVVKDIIEPGTYVGVPAKKIK" FT gene 12605..>12958 FT /gene="neuA" FT CDS 12605..>12958 FT /codon_start=1 FT /transl_table=11 FT /gene="neuA" FT /product="CMP-N-acetylneuraminic acid synthetase" FT /db_xref="GOA:A8JZW8" FT /db_xref="InterPro:IPR003329" FT /db_xref="UniProtKB/TrEMBL:A8JZW8" FT /protein_id="ABV59017.1" FT /translation="MKPICIIPARSGSKGLPDKNMLFLAGKPMIFHTIDAAIESGMFDK FT KDIFVSTDSELYREICLERGISVVMRKPELSTDQATSYDMLKDFLSDYEDNQEFVLLQV FT TSPLRKSWHIKEAM" XX SQ Sequence 12958 BP; 4483 A; 1703 C; 2273 G; 4499 T; 0 other; gcaaaagaac agatggaaca aagtggttca aagttcttag gtattattct taataaagtt 60 agtgaatctg ttgctactta cggcgattac ggcgattatg gaaattacgg aaaaagggat 120 agaaaaagga agtaaggggc tcttgtattg aaagaaaaag aaaatataca aaagattatt 180 atagcgatga ttcaaacagt tgtggtttat ttttctgcaa gtttgacatt aacattaatt 240 actcccaatt ttaaaagcaa taaagattta ttgtttgttc tattgataca ttatattgtc 300 ttttatcttt ctgattttta cagagacttt tggagtcgtg gctatcttga agagtttaaa 360 atggtattga aatacagctt ttactatatt ttcatatcaa gttcattatt ttttattttt 420 aaaaactcat ttacaacgac acgactttcc ttttttcctt ttattgctat gaattcgatt 480 ttattatatc tattgaattc atttttaaaa tattatcgaa aatattctta cgctaagttt 540 tcacgagata ccaaagttgt tttgataacg aataaggatt ctttatcaaa aatgaccttt 600 aagaataaat acgaccataa ttatatcgct gtctgtatct tggactcctc tgaaaaggat 660 tgttatgatt tgaaacataa ctcgttaagg ataataaaca aagatgctct tacttcagag 720 ttaacctgct taactgttga tcaagctttt attaacatac ccattgaatt atttggtaaa 780 taccaaatac aagatattat taatgacatt gaagcaatgg gagtgattgt caatgttaat 840 gtagaggcac ttagctttga taatatagga gaaaagcgaa tccaaacttt tgaaggatat 900 agtgttatta catattctat gaaattctat aaatatagtc accttatagc aaaacgattt 960 ttggatatca tgggtgctat tataggtttg ctcatatgtg gcattgtggc aatttttcta 1020 gttccgcaaa tcagaaaaga tggtggaccg gctatctttt ctcaaaatag agtaggtcgt 1080 aatggtagga tttttagatt ctataaattc agatcaatgc gagtagatgc agaacaaatt 1140 aagaaagatt tattagttca caatcaaatg acagggctaa tgtttaagtt agacgatgat 1200 cctagaatta ctaaaatagg aaaatttatt cgaaaaacaa gcatagatga gttgcctcaa 1260 ttctataatg ttttaaaagg tgatatgagt ttagtaggaa cacgccctcc cacagttgat 1320 gaatatgaaa agtataattc aacgcagaag cgacgcctta gttttaagcc aggaatcact 1380 ggtttgtggc aaatatctgg tagaaataat attactgatt ttgatgaaat cgtaaagtta 1440 gatgttcaat atatcaatga atggtctatt tggtcagata ttaagattat tctcctaaca 1500 ttaaaggtag tcttacttgg gacaggagct aagtaaaggt aaggtttgaa aggaatataa 1560 tgaaaatttg tctggttggt tcaagtggtg gtcatctagc acacttgaac cttttgaaac 1620 ccatttggga aaaagaagat aggttttggg taacctttga taaagaagat gctaggagta 1680 ttctaagaga agagattgta tatcattgct tctttccaac aaaccgtaat gtcaaaaact 1740 tggtaaaaaa tactattcta gcttttaagg tccttagaaa agaaagacca gatgttatca 1800 tatcatctgg tgccgctgta gcagtaccat tcttttatat tggtaagtta tttggttgta 1860 agaccgttta tatagaggtt ttcgacagga tagataaacc aactttgaca ggaaaattag 1920 tgtatcctgt aacagataaa tttattgttc agtgggaaga aatgaaaaaa gtttatccta 1980 aggcaattaa tttaggagga attttttaat gatttttgtc acagtgggga cacatgaaca 2040 gcagttcaac cgtcttatta aagaagttga tagattaaaa gggacaggtg ctattgatca 2100 agaagtgttc attcaaacgg gttactcaga ctttgaacct cagaattgtc agtggtcaaa 2160 atttctctca tatgatgata tgaactctta catgaaagaa gctgagattg ttatcacaca 2220 tggcggccca gcgacgttta tgaatgcagt ttctaaagga aaaaaaacta ttgtggctcc 2280 tagacaagaa cagtttggag agcatgtgaa taatcatcag gtggatttcg ttaataaggt 2340 aaaaacaatg tataattttg atatcgttgt agatattgaa aggttacaaa atgtagtcta 2400 tgaggggacg atgaatcgtc cgtttttaga aactaacaga agtaatttta ttgaagaatt 2460 taaggtaata ttaaaggagt tgtgtgatga aaatcaataa aaataaaaat tatttttttg 2520 aagtaatttt tatcatactt ttttctctat tagctctata tacaggtgtt tacagggacg 2580 gaaattatct ttatgactat ctttttttac tttatgcttt ttatgcattt ctgaggtcaa 2640 tcacaattac ttattctaga aaagaaataa taattttaat aagtgtaaca attctttttg 2700 ttctaaatag ttttttttca aaaggtaata gttggctttc tattttgata atattattag 2760 ggagtaggaa gatagctatt gataggatta tagatagttt attaatatgt aagattattt 2820 catttatagg cgttttaaca tttgtaaacc ttcatatttt agaaaataag caagttctca 2880 catatagata tggtgaagta gtagcaaggt atgcatatgg atttaatcat cccaatacct 2940 tacatgcctt tttctttata ataataatgc tatttatcta ccgtttcttt actaaattaa 3000 agtatcttca tttagtaatc attttaatta ttaatcagta tatttattct atttcagttg 3060 ctagaacagg ttatttttta gtaatatttg cagtagtatt ttacattatt ctacgaaata 3120 attttttgat acagcaagta acttttaaaa tagcaccgta tgtacagttt attgcgatgt 3180 ttagtttgtt attattttct ttatttttct ttaatactcc tattgtttca aaattagata 3240 accttttaag tggtagaatt tattacgcga agcttatctt aacagattca cttaatttat 3300 ttggaaatga aatcaactat tttattgata gatatatttt attttttcat gataacagtt 3360 attcttcaac acttgcacta agtggaatta ttattacatt tgggtatatg tacttatatt 3420 ttaaaacctc tcgaaagtta gtgcaggatc ataatattgc tgctttatat ttatttgttt 3480 caaattcctt gttattttac tccgaagatt atatacgcga gccattttta aatattactt 3540 tattttttat aggtaaatat atatttaatg aattaggaga gataaatgag tgataaattt 3600 tcaaataaaa tcagtgttat agttccttta tataatgtag agaaatatat tataaattgt 3660 atttcttcac ttacgaatca aacttatcag aatatagaaa ttattttgat agatgatggt 3720 tctactgata atagtggtag gatatgcaaa aaattagctc aagaggatca tcgtattatt 3780 tatttaagga aagaaaatgg tggggtttct agtgctcgaa atttagggct acaatatgca 3840 acaggaagtt acattggttt tgtagactca gatgactata tatcaaaaac aatgtatgaa 3900 aacttattaa agagattatt agaaactaat gcggatatcg ccgaaactga ctttgcctta 3960 attgataata gatttacgaa aaaaaagagg aaaaagatac agaaagttct gaataaagaa 4020 gaagctatta gggagttttt atcaggaaat gtggttgaaa ataatctcgt cataaagtta 4080 tttaaaaaaa cagttattgc taatctaaaa tttaaagaag atgtgatagt tggtgaagat 4140 atgctatttt ctttgcaggc cttacaaaac tcagatagag ttacagtgga cactacgaat 4200 gcggattatt tttatgtcgt acgttcaaat tcaactatga atactattac cgagaaggat 4260 atcgataatc tttcaatact cgagcaggag ttcaaaaaaa ttgatatccc ccaattaaaa 4320 agttatttgg aagccaaatt aattcgagaa aaggttaaat ttgtatctag agtattaatt 4380 agtaataaag cacatttgta cagtgatatt attgatagat atttgcaaga ggttagacac 4440 tacagcataa aaaatatgat aaactttctt tcgtcgaaac attgtttgac tataactatt 4500 atgaaaatat cacctaaact atatacactt ttatataaag tttttcaaaa gcaataaata 4560 tcggaacgga ggcttttatt ggaaaagatt agtattatta taccggtata caatgttaag 4620 aagtatctta atgattgtat tcaatctgtt ataaaccaga cttacaataa tttagagatt 4680 attttaattg atgatggttc taccgatggt tcaggagact attgtgatga aattgccaaa 4740 aaagatagtc gaatttttgt gtatcataag acaaacggcg gtctatcaga agctcgaaac 4800 gttggaataa aaataagtac cgggaaatat attacattta tagattcaga cgattacatc 4860 gaaaatttat atattgaaac tttatacaac agtttaattg agtataaggc tgatattgct 4920 attgttaata aatatcattt aaaggataac gagaaaattg ttcatttggc aaattccaaa 4980 gaacttttta gggtatttga tactaaaatg attttagaga gtatgtatag tagagagaat 5040 aattttatta gtaccctgac aatggcgcag ctaaaattat atcgtaagga acttttctct 5100 gatatagaat ttcccattgg gaaaaaatat gaagattctt ttacaactta taagacatac 5160 attgaagcta ataggattgt ttttgttaat agaccattat atgcctatcg atttcgaagt 5220 gggagcatta caagaagtgg ttatcaatta tcaaatttag acgttttaga aatgtacgaa 5280 gagcggttgg aatattttag agaaagagga tatgatttac ttagtactaa atatcattat 5340 tgtatagcta ttgcaaatca aaaagagtta ttaaaaaaac atttccctaa taatcctaaa 5400 atttataaat tggacagcca gtttagagaa atatattgtg atattttaaa tgaacttccc 5460 tttaaaaagc gaataaaatt aggaattatt aggttcttac catttattaa acggttaaaa 5520 taccaattta ttgaaagtag atgatatgca acatatatta gcaattatta gttataaaat 5580 gacacatgca ttaaaatgta ccgtagattt attgaaaaat gatatggata tagttataca 5640 cgttgatgcc aaaagtgata taaaacaata tgattcgata aaagaatttg taactttcac 5700 agaagaaaga atagatgttc gttggggaca ctattctcag attttagcta tgttagttct 5760 tttaaaatat atgaagtcca aagaaaaata tcattatatt tctattatta gtgaaagcga 5820 catcccatta aaaacaggta aagaaattaa tactttttta acccttcata aaggtaaaga 5880 attcataggt atggtttcta acgagcaaat gagtgatttt gagtatgata aactcaagta 5940 taactatcct gatttttgtt tttctaaaag aggaatattt aaaaaaattt atagaggtac 6000 caaagtttat aggttcttta aaaatgcaag gtattattcc ctacctcctc ttcgtaaggg 6060 aagtcagtgg tttactattt caagagagtt tactgactgg attattggat atttagataa 6120 acacccagat tatcaggagg ctttttgtca tagctattgt ggagatgaat tattttttca 6180 aacattacta gctatctctc catttcaaga aagggtgatg aataataaag atgactgtct 6240 catgggaggg agatatatta tttgggaggc tgataagaca tcaccttgcg atttatttgc 6300 tgaaaaagtg ttagaatata ggaaagaagc tgagagtgct ttattcttta gaaaagtatc 6360 tgaagaaagc gattttgatg tttatatgca tctattaaat aaactttaaa ttaaggagaa 6420 aatattgaaa cttttattta ttgttccata ttttggaaaa tttaatagtt attttcagtt 6480 atttttaaac tcaatagcca catcagatct ttgtgattta ttgattgtta ccgatgataa 6540 aagtaaatac gattaccctc agaatgttac tattcgctat actagttttg aagagttccg 6600 aaatgaagtc caaagaaaaa tggattttaa aattacttta gatactccat acaaactctg 6660 tgattttaaa ccaacatacg gttatctatt tgaagatgaa ttgttaaatt atcaatattg 6720 gggttattgt gacttagata ttatctttgg tgatttagat ggatttttac atcccatact 6780 aaataaaggc tttgataaaa tttttgagct aggtcattgt acgattatta agaatgaatc 6840 acgaataaat cgaatgttcc tttctacagt taatggggtg aaaataggac aaaaagctct 6900 aagttcttcc aaaatcgaag tttttgatga ggcatatgtt aatagtatta ataatatatt 6960 tattgaaaat aattgtaata actttttgta cagtttagga gcagacatag acatttggaa 7020 gaataatttt tatattactt ctttcaagaa taaaaaagat tttgtagtat cagacgctcc 7080 cagcatattt tactatgaac aaggacactt atatgagttt caccaatata agtctgtagt 7140 aagaaggagt gagtatttat atattcatct tcaacaaaga aaaatgaaag ttgatttaga 7200 tgctaggtct acaacttatc tgatattacc aaataagttc gtagaatata gaatagctac 7260 aaattgcttg ttaacactta aagaatttaa acggtttatt agttttggaa aatatagctt 7320 tcaaaaatac cgcctatata ctaaattaca aaagcaaaaa ataaagaagt tattatgaga 7380 ttttaatgaa aatgaagaat atttatatat gttacacttt atatcaccta ttgatatctt 7440 tatgtaagag agatttatat ggaaaaataa ttatcttaac tactcgaata aataattatg 7500 caatatataa aagaagaata gaaaagttgt ttccagaaat acctgtattg attgtagatg 7560 atagtgatta cagtaagaaa tataaattgt tttatccgaa gcgaataaaa caagaattgt 7620 ttagtataac caacggcaat aaaatacata tttacaatga ctatacgcaa ttaggatatt 7680 tttttcatag gaatgctatt ccctaccatt taatggaaga tggatataat agtttaaaac 7740 atccaacgag tatcgctcca gatggtcttt gtgacaagat aaaagggaag ataacgaata 7800 caccccgata tcatggcttc agtaagtatt gtaagacgat agaagtaagt agtttgaaag 7860 atttaccaac agatgagaga atgtctaagt ttattgagaa gcccaaggat ggattatttt 7920 ctgatttaga taataaaact aaggaatcta ttttaaagat ttttgacata gcctcaatag 7980 atattgaaat agcttctcca tctgctctaa tattaactca acctttagag gaacatttta 8040 aaagtcaaga ggaaatatac caattttaca aaagcatagt ggaagaatat attgataaag 8100 gttaccacat atatattaaa gttcacccta gagataacat tgactactct aatctcaatg 8160 caacagtaat acaaaggaac atccctatag aattatttga tttcctagag aatataaaat 8220 ttgatgttgg gattacatat ttttccacgg cattagattt tttaaattgt gttaataaaa 8280 aaattttctt atacaatatt aaggatatta aatgaatact aagaaattac ttcaatctgg 8340 ttttatttat acactcggga atttattggt gcaaggatta gcctttatca cacttcccat 8400 ctacactcgg gtcatctcaa cagaagttta tggccaatat agtttatatg tcgcttggat 8460 gaatattatt atgcttttta ttggccttca gacgagcggt tctttaagtt cagcccgggt 8520 caaatacgga gaagaattta aaagctattc tgggagtgcc ttttctgtag gtaatatatg 8580 gtttcttatt atacttttga tagcttttct atttagaagt tttcttgcac cattagttgg 8640 tttttctgaa tctatttttt tattaatggt gtgtcaaagt tacgctagct atgtggtgac 8700 tttctttggt cagtatttta tacaacaaca gaggagtttg gctaatttaa tattatcctt 8760 agccaatgca gtttcatctg ttgcactatc tctattttta atttttcatt ggtccgatga 8820 ctttttatct agggttttgg gagcttttgt tcctactata ataactggaa tagttgcctt 8880 tgcttatatt tattatcata gcaaatcttt ttacaatcct aagtattttc ggttcattgt 8940 cactgtgtct attcctttga tttttcattt gttaggacat cagttattaa atcaattaga 9000 taggattatg ctagttcgct tatatagtac taaagaagtt gcaatgtata gtttcggtta 9060 ttcgcttgga atgattattc agattgtttt gaatagtatt aatatggctt ggattccatg 9120 gttttttgat gctagaaaag aaaaattact gcaactttca acttatatta gccgttatct 9180 ctatttagga gttttcttaa cattaggtta tttgactgtt tttcctgagt tagctcaaat 9240 aatgggagga gacaagtata gtagtagtgt tcaatttatt tctttaatta ttgtcagcta 9300 ctttttagtc tttctctata catttcctgt aaatatccaa ttcttctatg ctaatacgac 9360 atggattcct attgggacat tattagctgc tggtgtaaat tggttactaa accttgtatt 9420 aattcctcat tatgcagcct atggcgctgc tatggctaca ataatatctt atttagcctt 9480 gttgattttt catcatattg tttcgaaagt taaataccat tattcagatg tctcagttag 9540 gcagtacatc attttaagtg gtatagtatt tagttatgct atgttaatga acatgttcct 9600 agataatatc gttattagat ggagtttagg aataattatt cttatagtat atagcattgt 9660 ttttcaaaaa gtcattttag acttattgag taaaaaaaga aggagaagat aatggtttat 9720 attattgcag agattggttg caatcataat ggagatatta atcttgcgaa aaaaatggta 9780 gatgttgccg tgtcttgtgg tgttgatgct gttaaatttc agacttttaa agctgagaaa 9840 cttatttcta aatttgctcc caaagctgaa tatcaaaaag caactacagg aacagcagac 9900 agtcaacttg agatgacgaa acgtttagag ttaagctttg aagaatactt agaaatgcgt 9960 gattatgcaa tttcaaaagg tgtggagacc ttttcaacac cttttgatga agagtcatta 10020 gagttcttaa tttctacaga tatgccaatt tacaaaattc catcaggaga aatcactaat 10080 ttaccttact tagaaaagat tggcaagcaa caaaagaaag ttattctttc gacgggtatg 10140 gcggtaatgg aagagatcca tcaagcggtg aatattttac gtcagaatgg tacaaccgac 10200 atttctattt tacattgtac aacagagtac ccaacacctt acccctctct aaatttaaac 10260 gttattcata ctttgaaaga tgaatttaaa gatttaacga taggttattc ggatcattca 10320 attggatcag aagtacctat cgcagcagca gcaatgggtg cagaagttat tgaaaaacac 10380 tttactttag atactaatat ggaaggtccg gatcataaag ccagtgcaac acctgatatt 10440 ttagctgctt tagttaaagg ggttcgcatt gttgaacaag ccttaggtag atttgaaaaa 10500 atcccagatc cagtagaaga gaaaaataag attgttgctc gtaaatcagt cgttgcttta 10560 aaaccaatta aaaaaggcga tatttattca atagaaaata ttacggtgaa gcgcccaggt 10620 aatggtattt ctcctatgaa ctggtatgac atcttgggac aagaagcgca agatgatttc 10680 gaagaggatg aagttattcg tgattcacgc tttgaaaatc aattgcccga gttataataa 10740 cacctaatta taatcggcaa cagatgtatt acacggctaa gattatgtaa ttactatata 10800 tagaagggat acgatgaaaa aaatttgttt agtaaccgga tcgcgtgctg aatacggaat 10860 aatgaagcca ttgattcaaa gattatcaaa agataaagaa gtcaacttac aaattattgc 10920 aacagcaatg catctggaag aaaaatacgg ctatacttat cgtcaaattg aagaagacgg 10980 ttttgatatt gcttataaag ttcccttaca tctttatgat actgacagaa gaactgtatc 11040 tactgcaatg gcgcatttac aactaggatt gaccaaaatt tttgacaagg aagactatga 11100 tctagtcatc attttagggg atcgttacga aatgttacca gttgtgaatg tagcgttgat 11160 ttataatgtc ccagtatgcc accttcatgg aggggagacc tcattaggca attttgatga 11220 gtatattcgc catgcaatta ctaagatgag tcacctacac ttagtctcta cagaggactt 11280 tcgtcaacgt gtgattcaga tgggagaaca acctcaattt gtaattaaca caggagctct 11340 cggagtggaa aatgctctat caatcccttc tctaaccaaa gaagcaatag aaaagcaatt 11400 aggtattgta ctagaggaat cctattttgt tgttctctat catcctgtta cttttgaaca 11460 aggaaaaagt gctggagaac agatgaaagc ggtactatca gccctttcta aatttggtgt 11520 ccagtgtcta tttataggat ccaattcaga tactggttct gatgatattg caaaggctat 11580 caatacttat ttgataaatc atgaaaatag ttattgcttt gcttctttat caacccaact 11640 ttatcattcc ttaattcgtc attcactagg actgattggt aattcgtctt ctggtttaat 11700 agaagttcct tctttgatga aacctactct taatattggt gatcgccaaa aaggtaggct 11760 acatggagaa agtgtagtaa gtgtaccagt cgaaacctcc tctgtattgg agggattatc 11820 aaaattgaat gaagtgacca actttgacaa tccctactac aaagggaatg cttcatctat 11880 tgcatatgaa gcaataaagc tttatttgaa agatgaacct tcaatttccc aaccatttta 11940 tgatttaaag gagaataatc taaaatgaaa aaaaagttgg catttttagg cgcaggaagt 12000 catgctgatg cgattgctcc ggttattgat cctcttgtgt atgatttcgt aggttttttt 12060 gatgataaag atattacgga gcatgatggt tatcctgttc ttggaaaact ttatgatgtg 12120 ctaccttacc ttgaagatgg ctcaatagat gcagtattta ttacaatagg tgataatgct 12180 aaaaggaaag aactatttga atatgtagca aaggattatt atgactttat tattaacatc 12240 attagtccca atgctttagt attgacacca gatagtattt gtgggcgtgg tatctttatt 12300 ggttttgggg cttttatagg ttctaaagtg aagctgtttg ataacaacgt tgttaataca 12360 ggagcgctca ttgaacatca tactgttgta gaatcacact gtaatatagc acctaatgct 12420 accataaatg gtctttgtta tattagagaa gaagtttatg taggtagtgc cagtgttatt 12480 attcaaacct tggatatttc atcgtgtacg acaattggcg caggagctgt tgttgtaaaa 12540 gatattatag aacctggaac ctatgtaggg gttccagcca aaaaaataaa ataaaggata 12600 tgttatgaag ccaatttgta ttattcctgc gcgatcaggg tcaaaaggat taccagataa 12660 gaatatgtta ttcctagcag gtaaacccat gattttccat actatagatg ctgcaattga 12720 atctggaatg tttgataaga aagatatttt tgttagtaca gattcagaat tgtacagaga 12780 gatttgttta gaacgcggta tttcagtggt gatgagaaaa ccggaacttt caactgatca 12840 ggcaacttcg tatgatatgt taaaagattt tttatctgac tatgaagata atcaggagtt 12900 tgtgttactt caagtaacct ctccactaag aaaatcatgg catataaagg aagcaatg 12958 // |
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