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EBI DbfetchID EF382358; SV 1; linear; genomic DNA; STD; PRO; 12890 BP. XX AC EF382358; XX DT 14-JUN-2007 (Rel. 92, Created) DT 14-JUN-2007 (Rel. 92, Last updated, Version 1) XX DE Lactobacillus casei strain BL23 IolR (iolR) gene, complete cds; and DE myo-inositol catabolism operon, complete sequence. XX KW . XX OS Lactobacillus casei OC Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus. XX RN [1] RP 1-12890 RX DOI; 10.1128/AEM.00243-07 RX PUBMED; 17449687. RA Yebra M.J., Zuniga M., Beaufils S., Perez-Martinez G., Deutscher J., RA Monedero V.; RT "Identification of a gene cluster enabling Lactobacillus casei BL23 to RT utilize myo-inositol"; RL Appl. Environ. Microbiol. 73(12):3850-3858(2007). XX RN [2] RP 1-12890 RA Maze A., Boel G., Beaufils S., Hartke A., Zuniga M., Deutscher J.; RT ; RL Submitted (23-JAN-2007) to the EMBL/GenBank/DDBJ databases. RL Biotechnology, IATA-CSIC, P.O. Box 73, Burjassot, Valencia 46100, Spain XX FH Key Location/Qualifiers FH FT source 1..12890 FT /organism="Lactobacillus casei" FT /strain="BL23" FT /mol_type="genomic DNA" FT /db_xref="taxon:1582" FT repeat_region 7..25 FT gene complement(207..1013) FT /gene="iolR" FT CDS complement(207..1013) FT /codon_start=1 FT /transl_table=11 FT /gene="iolR" FT /product="IolR" FT /note="inositol operon repressor" FT /db_xref="GOA:A5YBJ1" FT /db_xref="InterPro:IPR018356" FT /db_xref="UniProtKB/TrEMBL:A5YBJ1" FT /protein_id="ABP57760.1" FT /translation="MLRKERIDAMQHYINEVRTASMKELEDKFSIAPSTLRRDLANLID FT AGTVKKVYGGVTATFNRAKPNALTIYSERQLSAPSEKRQIGRAAAQLIEPDDLIFIDSG FT TTTAEMGAYLPSEFSFTLVTNNLEIINKAAPLGNIKLVIIGMNFDRRTQSFTGIDNMNI FT FSRFNIGKAFMAATGISITRGLSNSEYNEYLIKSEIFKKAHQKILLIDHTKFDRVSLLT FT YGTLKDIDAIITYGDIAPKYIDFLAENDVQLINAQTGSIVSESADK" FT operon 1557..12795 FT /operon="myo-inositol catabolism" FT /note="iol" FT gene 1557..3047 FT /operon="myo-inositol catabolism" FT /gene="iolT" FT CDS 1557..3047 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolT" FT /product="IolT" FT /note="myo-inositol transporter" FT /db_xref="GOA:A5YBJ2" FT /db_xref="InterPro:IPR003663" FT /db_xref="UniProtKB/TrEMBL:A5YBJ2" FT /protein_id="ABP57761.1" FT /translation="MRKELEAVANKADVALAAQKEAAMLSEKLPKSARKRLRIISVIAT FT FGGMLFGYDTGVINGALPFMTRASELNMSPGMEGFVASSLTLGAAFGAVLTGRISDRKG FT RHKVITGLAMLFVVSTIASALSPNAPILAGVRFILGLAVGGTSVIVPTFLAEVAPSNLR FT GRIVTQNEFMIVSGQLLAFVFNAILGTTLGHIPGIWRWMLVLATIPAIILWIGMSFVPE FT SPRWLAANGKLDQALKVLREIRTEAQAKDEMEKIKISLKSAQEVGNASIKDLKISWIRR FT LVLIGIGLGIMQQIVGINVMMYYGTTILQTTGFGQNAALIANILNGVTSVVATIVTMHL FT MSKFKRRQMLLTGISGTLFSLVGITLTSHFLNGSPLLPYATILLTIIYLAFFQGALGPL FT TWLLLSEIYPARLRGLGMGFATFFLWISNFFVGYFFPVMLAGLGMSNTFLVFVGANILS FT LIFAWKFAPETAGRSLEEIELDNKYDDKFPEESQINKN" FT gene 3124..4602 FT /operon="myo-inositol catabolism" FT /gene="iolA" FT CDS 3124..4602 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolA" FT /product="IolA" FT /note="malonate semialdehyde dehydrogenase" FT /db_xref="GOA:A5YBJ3" FT /db_xref="InterPro:IPR010061" FT /db_xref="UniProtKB/Swiss-Prot:A5YBJ3" FT /protein_id="ABP57762.1" FT /translation="MDTTKQNVKTLKNFINGKWVDAKTETFENVYNPATGDVLARVPHS FT TSEDVADAVTAAKEAFKIWQKVSIPKRAKILFKYQQLLVEHQEELGRIVTEENGKSLDE FT AVAEVGRGIENVEFAAGVPTLMMGDSLSSVATDVEATNYRYPIGVVGGITPFNFPMMVP FT CWMFPMAVATGNTFILKPSEKTPLTSQRLVELFQEAGLPDGVLNIVNGAVDVVNGILDH FT PDIKAISFVGSERVGEYVYKRGSDHLKRVQALTGAKNHTIVLADADLDAAVKGIISSSF FT GSAGERCMATSVLVLQDEIADKFMAKFTQAAKDIKIGNGLDKGVFLGPVIRKENQERTL FT NYIQTGVKEGAKLVLDGSAEAKKHDGYFVGPTIFEDVKTDMTIWHDEMFAPVLSVIRAK FT DLPQAVAIANTSELANGACLFTDSAASIRYFRENIDAGMLGINLGVPAPIAVFPFSGWK FT HSFFGTLHANGKDSVDFYTHKKVVTARYDQRRFK" FT gene 4647..5462 FT /operon="myo-inositol catabolism" FT /gene="iolB" FT CDS 4647..5462 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolB" FT /product="IolB" FT /db_xref="GOA:A5YBJ4" FT /db_xref="InterPro:IPR010669" FT /db_xref="UniProtKB/Swiss-Prot:A5YBJ4" FT /protein_id="ABP57763.1" FT /translation="MSLLYHKQNQELSSGVRLIQDVNASNSPMKYTAVKVLEFSADSSY FT EETLEAFEAGIVVLEGKVTITADDQTFEDVGQRTSIFDKIPTDSVYVSTGLAFGIRAKQ FT AAKILIAYAPTNQTFPVRLIRGNIHQVEHRGKYNNKRLVQNILPDNLPFADKLLLVEVY FT TDSANWSSYPPHRHDHDDLPAESLLEEIYYHEMRPKQGFVFQRVYTDDLSLDETMAVQN FT QDVVVVPKGYHPVGVPDGYDSYYLNVMAGPTRVWHFHNAPEHAWIIDRQ" FT gene 5499..6479 FT /operon="myo-inositol catabolism" FT /gene="iolC" FT CDS 5499..6479 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolC" FT /product="IolC" FT /note="2-deoxy-5-keto-D-gluconate kinase; sugar kinase" FT /db_xref="GOA:A5YBJ5" FT /db_xref="InterPro:IPR002173" FT /db_xref="UniProtKB/Swiss-Prot:A5YBJ5" FT /protein_id="ABP57764.1" FT /translation="MPQKFDLIAIGRAAVDLNAVEYNRPLEDTKTFAKFVGGSPANIAI FT GSAKLGQKVGFIGKVSDDQLGHYVTQYMASVGIDTSNMVKDDTGHKIGLTFTEIISPEE FT SDILMYRNEAADLYLNAHEVSRAYLAQTKMLVISGTGLAQSPSREAILKALLIAKELGV FT EVIFELDYRPYTWQNAEETSLYYQLVAQKADVIIGTRDEFDVLENHQGRTDQETIATLF FT QYDANLIVIKSGIQGSNAYTKAGETYHFGVFKTKVLKSFGAGDSFAAGFLYAYQHQLGL FT ETALKYGSAAASIVISQLSSSEAMPNLDQLTAFIEKAEAQEVHQS" FT gene 6476..8431 FT /operon="myo-inositol catabolism" FT /gene="iolD" FT CDS 6476..8431 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolD" FT /product="IolD" FT /note="acetolactate synthase-like" FT /db_xref="GOA:A5YBJ6" FT /db_xref="InterPro:IPR012000" FT /db_xref="UniProtKB/Swiss-Prot:A5YBJ6" FT /protein_id="ABP57765.1" FT /translation="MTATELNAQVAADAKKETIRLTTAQALVRFLNQQYIDVDGQVTSF FT VEGLFAIFGHGNVLGLGEALQEDPGHLKVYQGHNEQGMASTAIAYSRQLYRHKIFAVTA FT SAGPGSANFVTAAGNAYVNSIPILFLPADTFATRQPDPVLQQIEVDYSADTTTNDVLKP FT VSKYWDRIERPEQLMSALLKAFEVLTNPATAGPVTIALPQDVEGQAYDYPLSFFKKRVH FT VVKRVQPSSAELAGAVELIQASQTPVLIVGGGAKFSDAGAAIETFSERFNIPIVETPTG FT KSAISSDFPNNMGGTGILGTAAANAVITKADLIIGAGTRYTDFTTASKTAIHPGKTQLI FT NINLNRMQSYKFDAFPIVADVRDTLSQLTESLSDYRSQFTDLATIKEAWQKERQRLAHT FT NYDAPAYVPEVKNQFDAKTMAAYAEKLQTHLTQTEAVIAVNNTIDPTSIIVAAAGSLPG FT DVQRIWDPVVPNTYHMEYGYSMMGYEVPAALGIKLAQPDQESYALVGDGSFMMLHSELV FT TALQYHKKINILVFDNSGFASINNLQMAQGSNSYLTEFRTSDNDIMKTDFAKIAEGYGA FT KAYRANDRKSLIAAIEDAKKQTVSTLIDIKVLPKTMTQGYGQSWWRVGVSEISNNPKVQ FT KAYQDIQTGIDKAFKY" FT gene 8445..9485 FT /operon="myo-inositol catabolism" FT /gene="iolG1" FT CDS 8445..9485 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolG1" FT /product="inositol dehydrogenase" FT /db_xref="GOA:A5YBJ7" FT /db_xref="InterPro:IPR000683" FT /db_xref="UniProtKB/Swiss-Prot:A5YBJ7" FT /protein_id="ABP57766.1" FT /translation="MVVKVGVIGTGAMGRAHIDRLTNVLTGAEVVAVTDIDHEAAEAAV FT RDFHLNAKVYPDDTSLLQDPDIDAVFVVSFGGAHEATVLKALDTDKFIFTEKPLATTLE FT GAKRIVDKELTKSKKVIQVGFMRRYDQGIRALKEKLDTGIIGAPLVVRASHINPNVASN FT YSNEMAITDTLIHEIDEMHWLLDDEYTSIQITYPRQSAEVRNEGLHDPQLATLTTKKGT FT VIQVLVHVTAQYGYEVKLEVIGETGELQLPNYGLGPILRSNANQQTAVEMSWINRFIQA FT YNTEVQEFIDQVAKSEPPVGPSAWDGYIAAITAAAANRSQKDQETVLINVAGTPTFYQN FT KNAIHA" FT gene 9523..10575 FT /operon="myo-inositol catabolism" FT /gene="iolG2" FT CDS 9523..10575 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolG2" FT /product="inositol dehydrogenase" FT /db_xref="GOA:A5YBJ8" FT /db_xref="InterPro:IPR016040" FT /db_xref="UniProtKB/TrEMBL:A5YBJ8" FT /protein_id="ABP57767.1" FT /translation="MTQKTIKIGIVGLGRLGKIHATNIATKIQHAKLQAATSVVPAELD FT WAKKELGVEEVFEDFDDMVQHADIDAVFIVSPSGFHLQQIESALNAGKHVFSEKPIGLD FT IEAIEHTQQVIAQHANLKFQLGFMRRFDDSYRYAKQLVDQGKIGDITLIRSYSIDPAAG FT MASFVKFATSANSGGLFLDMSIHDIDVIRWFTGKEIDKVWAIGLNRAYPVLDKAGELET FT GAALMQLEDKTMAILVAGRNAAHGYHVETEIIGTKGMLRIAQVPEKNLVTVMNEEGIIR FT PTSQNFPERFAQAFLSEEQAFVNSILNNQDVGITAEDGLQGTKAALALQEAFEKNDIVQ FT VASVDKKVGA" FT gene 10577..11473 FT /operon="myo-inositol catabolism" FT /gene="iolE" FT CDS 10577..11473 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolE" FT /product="inosose dehydratase" FT /db_xref="GOA:A5YBJ9" FT /db_xref="InterPro:IPR012307" FT /db_xref="UniProtKB/Swiss-Prot:A5YBJ9" FT /protein_id="ABP57768.1" FT /translation="MTIELGIAPIGWTNDDMPELGKEVTFEQAIDEMTLAGYKGTEVGN FT KYPKDPKTLKHFLDLRHLKIASAWFSAFLTTKPYEETEAAFIKHRDFLHAMGAKVIVVA FT EQGHSVQGLLDKSVFDDKPHFTDDEWERLATGLERLGDRAREVGMQIVYHHHMGTGVQT FT TAEIDRLMTMTDPDKVSLLFDTGHLVLSGEDPLTIFNRYQDRIKHIHFKDVRQQQADEE FT HKDHLSFLAGVKNGMFTVPGDGMIDFKPIWEAIQESGYDGWIIVEAEQDPAKANPFEYA FT LKAKKYLDATMNIPQSA" FT gene 11496..12368 FT /operon="myo-inositol catabolism" FT /gene="iolJ" FT CDS 11496..12368 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolJ" FT /product="2-deoxy-5-keto-D-gluconic acid-6-phosphate FT dihydroxyacetone-phosphate lyase" FT /db_xref="GOA:A5YBK0" FT /db_xref="InterPro:IPR000771" FT /db_xref="UniProtKB/TrEMBL:A5YBK0" FT /protein_id="ABP57769.1" FT /translation="MALVSATSLVAPALADRYAIGHFNINGADWLETYLKVAQTTKTPI FT IVATSDRIIDFLGGFDYMARYVRFMMQALSVTVPVALHLDHGLSVDHVYQAIDAGYTSV FT MFDGSKLPIGENVALTKEVVAYAHAHHVSVEAEVGSVGGNENGLVNGIRYASVADAVEM FT ASTGIDALAAALGSVHGDYVGRPNLNFERMAEIAAATKLPLVLHGASGILDDQIQQAIQ FT LGTAKININTEVNTVWTSAVTKALQAKRSNHDPQPILTAGKQAIAYLVEAKMKAFHVLG FT KSTRLSSMS" FT gene 12406..12795 FT /operon="myo-inositol catabolism" FT /gene="iolK" FT CDS 12406..12795 FT /codon_start=1 FT /transl_table=11 FT /operon="myo-inositol catabolism" FT /gene="iolK" FT /product="malonate semialdehyde decarboxylase" FT /note="tautomerase family" FT /db_xref="GOA:A5YBK1" FT /db_xref="InterPro:IPR004370" FT /db_xref="UniProtKB/TrEMBL:A5YBK1" FT /protein_id="ABP57770.1" FT /translation="MPLIRFDMIKGRSPEEIKDILQIAHEVMVAAFDVPPRDRYQIVHQ FT HEPYEMVVEDTGLDIPRTDRVIVISIVSRVRTIRQLKKFYQDLADKLETAGLVDKNDLM FT INVSFNDDQGWSFGQGKAQFLEGSL" FT repeat_region 12872..12890 XX SQ Sequence 12890 BP; 3719 A; 2485 C; 3118 G; 3568 T; 0 other; cagatacaac ggatttctaa ggcaagcgtc tatataaggg gattcagtgt aactgattgc 60 ttaatgatca agtattcctg atgaacttat aaataaaaaa tgacttcatt ccaaattttg 120 gggaatgaag tcatttttgt ttttattgtg tgtcatgtga atgcagcaac agctgattga 180 ggcgttcaac tagatgaaaa gcggggttat ttatcggctg actcggaaac gatgctgcct 240 gtttgtgcat taattagctg aacgtcattt tcagcaagaa agtcgatata cttgggcgca 300 atgtcgccat aggtgataat ggcatcaatg tccttcaaag taccataggt cagtaatgaa 360 acacgatcaa acttagtgtg atcgattaac agtatttttt gatgcgcttt tttaaaaatc 420 tcagatttaa tcaaatattc gttatattca gagtttgaca gccctctagt aatagaaatg 480 cctgttgctg ccataaaggc tttgccaata ttaaagcgac tgaaaatatt catattgtca 540 attcctgtaa aggactgggt tcgtcgatca aaattcatgc caataatgac caacttaata 600 ttcccaaggg gagcggcttt attaatgatc tctaaattgt tagtgacgag tgtaaatgaa 660 aactcggaag gtaaataggc gcccatttca gccgttgttg taccagagtc aatgaaaatc 720 aaatcgtctg gttcgattaa ttgcgcagcg gctcgaccaa tttgacgttt ttcggaggga 780 gcagaaagtt gccgttcact atagatggtt agcgcgttgg gcttcgctct gttaaaggta 840 gcagtgacac cgccgtatac ttttttgaca gtaccagcat cgattaagtt agcaagatct 900 ctacggagtg tgctaggggc tatagaaaat ttgtcttcga gttccttcat ggaagcagtt 960 ctgacttcgt taatataatg ctgcatcgca tcaattcgtt cttttctaag catggatgtc 1020 accttccttt ctaaacaatt ggtcaacctg attatagcat aaggcggtca acttaatgac 1080 catattttga ctaaaagaag aacacctatt tattgatcaa gtgactttat caataaattg 1140 agagtttggt taatacaatc aagcctgaat gaattcgacc gcgtgatttt cgccgttgtc 1200 tcagacatga tcaatagcat cgattagaat catgcgaaac caagttccta aaaaatctag 1260 aaatcgtgat tcttcgtagg caaggggatg gccacaaatg aacgtttaaa catactgcat 1320 tttgagtggt agcatgctga ataactgttt gaactgactt aatcatacca tcgtgcgaat 1380 tcacatttca tcttttaaga cgtatataga taaatggtga acatgttgtg aacaagtgtt 1440 gagtacattt tagttgactt tgatctgatt aaactctatg atggcaatgt gatcataaag 1500 taagcgctta attcgttgct cttataaagc tttagtcagt ttggagggtt taagaaatgc 1560 gcaaagaatt agaagccgtt gcgaacaaag ccgatgttgc actcgctgca caaaaagaag 1620 cggctatgct ttcggaaaaa ctgcctaagt cagctcgtaa acgactacgc attatttcag 1680 tgattgccac ttttggcggc atgctgttcg ggtatgatac gggtgtgatt aatggcgcac 1740 taccatttat gacgcgagca agtgaactta acatgtcgcc tggaatggaa ggatttgttg 1800 ccagctcatt aacacttggt gctgcattcg gtgcagtgct gactgggaga atctctgatc 1860 gaaaagggcg ccataaagtc atcactggct tagccatgtt gtttgtcgtt tcaaccattg 1920 catctgcgtt atcaccaaat gcccctatat tagctggtgt tcgctttatt ctagggctgg 1980 cagttggcgg aacttcggtg atcgtgccaa cattcttggc tgaggtggcg ccatcgaatc 2040 tgcgcggaag aattgtgacg caaaatgagt tcatgattgt gtcaggacaa cttttggcct 2100 ttgtctttaa tgctattttg ggcacaactt tgggacacat tcccggcatt tggcgttgga 2160 tgctcgtatt ggcgaccata ccggccatca ttttatggat aggcatgagc tttgtgcctg 2220 agtcacctcg atggttagca gcaaatggta aattggatca agcgttaaaa gtattgcgtg 2280 aaatcagaac agaagcacag gctaaagatg aaatggaaaa aatcaaaatt tcattgaaat 2340 cagcgcagga agttggaaat gcttcgatta aggatttaaa gatttcctgg attcggcgct 2400 tggtcttaat cggcattggg ttaggcatca tgcaacaaat tgtcgggatt aatgtcatga 2460 tgtattacgg cacgacgatt ttgcaaacaa ctggtttcgg acaaaatgcg gcattaattg 2520 cgaatatttt aaatggtgtt acgtctgtcg ttgcaaccat tgtgactatg catttgatga 2580 gcaagtttaa acggcgacag atgcttttaa ctggtatcag tggaacgttg ttttcgctgg 2640 tcggcattac gttaactagc cattttctaa atggcagtcc cttgttacct tatgcgacaa 2700 ttctgttgac catcatttat ttagcctttt tccaaggagc tttagggccg ctaacttggt 2760 tattattgtc agagatttac ccagcccgtc ttcgtggatt gggcatgggc tttgcgacct 2820 tcttcttgtg gatcagtaac ttctttgtcg gttatttctt cccagttatg ttggcaggac 2880 tgggcatgtc gaataccttc ctagttttcg ttggcgccaa tattctctca ttgatctttg 2940 cttggaaatt tgctccggaa accgcaggca gatctttgga agaaattgaa ctggataata 3000 aatacgatga caagtttcct gaagaaagtc agattaacaa gaactagcta agcatcattt 3060 tcggaatatt tgaaagcgct ttaatgagtg ccgttacttc tgcattgaag ggagaaactc 3120 gaaatggata caactaagca aaatgttaag acgctaaaga attttatcaa tggtaaatgg 3180 gtggatgcaa aaacagaaac ttttgagaat gtttataacc cggccactgg agatgttttg 3240 gcgcgagtgc cacattcgac tagtgaagac gtagcagatg ctgttacggc agcaaaagag 3300 gcttttaaga tttggcaaaa ggtttcaatt ccaaagcgtg cgaagattct tttcaaatac 3360 caacaattat tggttgagca ccaagaagaa cttgggcgaa tcgtcactga agagaacgga 3420 aaaagccttg acgaagcagt tgctgaagtt ggacgaggta ttgaaaacgt tgaatttgct 3480 gctggtgtgc cgactttgat gatgggagat tcattgtcat cagtggccac tgatgtagaa 3540 gccacgaatt atcgttatcc aattggggtt gttggcggca ttacgccatt taactttccc 3600 atgatggtgc cttgctggat gtttccaatg gctgtagcaa ctggtaatac gtttattctg 3660 aaaccatctg aaaaaacacc gctaacgagt cagcggttgg ttgaactttt tcaagaagcg 3720 ggcttaccgg atggcgtgct caacatcgtt aatggtgcgg ttgatgttgt taatggcatt 3780 ttagatcatc cagacatcaa ggccattagt ttcgttggtt ctgaacgtgt cggcgagtac 3840 gtttataaac gaggcagtga ccatttgaag cgggttcagg ctttaacggg agccaagaat 3900 catacgattg ttctggccga tgccgatttg gatgcagcgg ttaaaggcat tattagctcc 3960 tcattcggct cagctggtga acgatgcatg gcgacatctg tcttggtcct tcaagatgag 4020 attgctgaca agtttatggc gaagtttacg caagcggcaa aggatatcaa gattggcaac 4080 ggccttgata aaggtgtctt cttgggaccg gttattcgca aagaaaatca agagcgaaca 4140 ttgaactaca tccaaacagg ggtcaaagaa ggcgccaagc ttgtgttgga tggttcagca 4200 gaagccaaga aacatgatgg gtattttgtc ggaccgacta tttttgaaga tgtcaaaaca 4260 gatatgacca tttggcatga tgaaatgttt gcgccggttc tctcggttat acgggcaaag 4320 gacttgccac aagcggttgc gatcgccaac acgtctgaat tggctaatgg ggcgtgcttg 4380 tttacagatt ctgcagcttc catccgttac tttagggaaa atattgatgc aggcatgttg 4440 ggtatcaatt taggtgttcc tgcaccgatt gcagtgttcc cgttctctgg ctggaaacat 4500 tctttctttg gcaccttaca tgctaatggt aaagacagtg tggactttta tacgcataag 4560 aaagttgtga ccgctcgata tgatcagcgg cgtttcaagt agacgatgaa caggataagg 4620 gtaagacact tacaaggggg attatcatga gcctgttata tcacaagcaa aatcaggaac 4680 tgtcttcagg tgttcggctg attcaggatg tgaatgcaag caactcaccg atgaaatata 4740 cagccgtcaa ggttctggaa ttttctgcag atagttcgta tgaagaaacc ttggaagcat 4800 tcgaagctgg cattgttgtg ctggaaggca aagtaactat cactgctgac gatcaaactt 4860 ttgaagatgt tggtcaacga acttcgattt ttgacaaaat ccccacagac agtgtgtatg 4920 tcagcacggg tttagcattt ggtattaggg ccaagcaggc tgccaaaatc ttgattgcct 4980 atgcaccaac gaatcaaacg tttccggttc ggctaattcg agggaatatt catcaggttg 5040 aacatcgcgg gaagtacaac aataaacggc ttgtgcagaa tattttgccg gacaatcttc 5100 cttttgccga caagctttta ttagtggaag tttatacgga ctcggcgaac tggtcgagtt 5160 acccgcctca caggcatgat catgatgatt tgccagcaga gtcactgtta gaggaaattt 5220 attatcatga aatgcgacct aaacaaggat tcgtttttca gcgtgtgtac acggatgatt 5280 tgagtttaga tgaaacgatg gctgtgcaaa atcaagatgt tgttgtggtg ccaaagggat 5340 atcacccagt gggtgtacct gacggctatg acagttatta tctcaacgtc atggcaggcc 5400 cgacgcgtgt ctggcatttt cacaatgcgc cggaacatgc gtggattatt gatcggcaat 5460 aagtaaccga gattattttt aaaggaggta aacttcagat gccacaaaaa tttgatttga 5520 ttgccattgg acgtgcagct gttgatctga atgccgttga atataatcgc cctttggaag 5580 atacgaaaac ttttgcaaaa tttgtgggtg ggtcacctgc caatattgcg ataggatctg 5640 ccaaacttgg acaaaaagtt ggctttattg ggaaagtctc tgacgatcaa ttaggccatt 5700 atgtcacgca atacatggct agtgtgggca ttgatacgtc caacatggtt aaagatgaca 5760 caggacacaa aattggacta acctttaccg aaattatcag tcctgaagaa agcgatattt 5820 taatgtatcg caatgaagca gctgacctat atcttaatgc gcatgaagtt tcgagggcat 5880 atttggctca gactaaaatg ctagtcattt ctggaactgg attggcacaa agtccttcac 5940 gagaagctat tcttaaggca ttgttaatcg ctaaagagct tggagtcgaa gtcatcttcg 6000 aattggatta tcggccttat acttggcaga atgccgaaga aacatctttg tactatcaac 6060 ttgtggctca aaaagcagat gtcatcatag gaacgcgtga tgagtttgac gttttggaaa 6120 atcaccaagg ccggacagat caagaaacca ttgccacatt attccaatat gacgcgaact 6180 taatcgtcat taaaagtggc atacaaggat ccaatgctta taccaaggct ggcgaaactt 6240 accacttcgg tgtcttcaag acaaaggtat taaagagctt tggggcaggc gattcttttg 6300 cggcgggatt tctgtacgcc tatcagcatc agttaggcct tgaaacagcg cttaaatatg 6360 gcagtgcagc agcctctatt gtcattagcc agttaagttc ttcagaagca atgcctaact 6420 tagaccagct aacagcgttc atcgaaaagg ccgaagctca ggaggtgcat cagtcatgac 6480 tgcgacggaa ttaaatgcac aagtagctgc agatgctaaa aaagaaacga ttcgactgac 6540 tacagcacaa gccttggttc gttttttgaa tcaacaatac attgatgtcg atggtcaagt 6600 gacatcattt gttgaaggcc tgtttgccat ctttggtcat ggtaatgtct tgggcttggg 6660 cgaggcgttg caggaagatc ctggtcattt gaaggtttac caaggacaca atgagcaagg 6720 aatggctagc acggcaatcg cttatagtcg gcaattatat cgccacaaga tatttgcagt 6780 cacggcttca gcaggccccg gatcagctaa ctttgtgacg gccgccggta acgcatatgt 6840 caatagcatc ccaattctgt ttttacccgc agacacattt gctacgcgcc agccagatcc 6900 agttttgcaa caaattgagg ttgactacag tgcagatacg acaacgaatg atgtgttgaa 6960 gccagtatcc aaatattggg atcggattga acgtcctgag caattgatga gtgcgctgct 7020 caaagctttt gaagttttga caaatccagc aacggccggc cccgtgacca tcgccttgcc 7080 tcaagatgtc gagggccaag cctatgatta tccactcagc tttttcaaga agcgtgttca 7140 tgttgttaaa cgggttcagc ctagctcagc cgagttggct ggagcagtcg aactgattca 7200 agcaagtcaa acgccagtct tgattgtagg cggcggggca aagtttagtg atgctggagc 7260 tgccattgaa acattttctg agcgatttaa cattccgatt gtagaaacac ccaccggcaa 7320 atcagcgatt tcttcagatt ttcctaataa tatgggaggt actggtatct taggcactgc 7380 cgctgccaat gcagtcatta ccaaagcgga tttgattatt ggggctggta cccggtatac 7440 ggatttcacg acagcttcta agacagcaat tcacccgggg aaaacgcaac ttatcaatat 7500 taatttgaat cgcatgcaat cgtataaatt tgacgctttt ccaattgtgg cagatgttcg 7560 ggatacgctc agtcagctga cagaaagttt atccgattac cgaagccagt ttaccgacct 7620 agcaaccatt aaagaggcgt ggcaaaaaga gcgtcaacgt ttggcacaca caaattacga 7680 tgctccggca tatgtacctg aagtcaaaaa tcaatttgat gctaaaacga tggccgctta 7740 tgcagagaag ttgcaaacac acctaacaca aactgaggca gttattgccg ttaacaatac 7800 gattgatccg acaagtatca tcgttgcagc tgcaggttcc ttgccgggcg atgtgcagcg 7860 gatttgggat ccagtcgtac caaatacgta tcacatggaa tacggctatt ccatgatggg 7920 atacgaggtg ccagctgctt tgggtattaa gctggcccaa cctgatcaag aaagttacgc 7980 attagtcgga gatggcagct ttatgatgct tcattccgaa ctagtgacag cactgcaata 8040 ccataagaaa atcaatattc tagtctttga taattcaggc tttgcttcca ttaataattt 8100 gcagatggcg caagggagca acagttatct cactgaattt cgcacttcgg acaacgatat 8160 tatgaagacc gattttgcca aaattgctga aggctacggg gcaaaagctt atcgcgctaa 8220 cgaccgcaaa agcttaattg cggccattga ggacgctaaa aagcaaacag tatcaacttt 8280 gatcgatatc aaagtcttac caaagacaat gactcagggt tatggccaaa gttggtggcg 8340 cgtgggagtt tcagaaattt ccaataatcc aaaagtgcaa aaagcgtatc aggatattca 8400 aacgggtatt gataaagcat ttaaatatta aaggagtgac aaatatggtt gtcaaagttg 8460 gtgtgattgg aacaggtgct atggggcgag cgcatattga tcgactgaca aatgttctca 8520 ctggtgcaga agttgtcgct gtcacggata ttgatcacga ggctgcagag gccgctgtga 8580 gagattttca tcttaacgct aaagtgtacc cagacgacac tagtctgcta caagatccag 8640 atattgatgc agttttcgtt gttagttttg gcggggcaca tgaggcgact gtcctgaaag 8700 cgttggatac tgacaaattt atttttaccg aaaagccgtt ggcaaccaca ttagaaggtg 8760 ccaaacggat tgttgataaa gaactgacaa agtctaaaaa agtgattcag gttggcttca 8820 tgcgtcggta tgatcagggc attcgtgcac ttaaggaaaa attggacact gggatcatcg 8880 gtgcgccatt agttgtccga gcgagtcata ttaatccaaa tgtagccagc aattattcaa 8940 atgaaatggc gattacggat accttgattc acgaaattga tgaaatgcat tggctgctag 9000 atgatgaata cacttctatt cagatcactt atccaagaca atcagcagag gttaggaatg 9060 aaggcttgca cgatccgcag ttggcaactt tgacaaccaa aaaagggaca gttattcagg 9120 tgttggttca tgtaacggct cagtatggtt atgaagttaa gctggaagtg atcggcgaaa 9180 caggcgaact gcagttaccg aattatggcc ttggaccgat tctgcgctca aatgctaatc 9240 agcaaacggc tgttgaaatg agttggatca accgatttat tcaggcatat aacactgaag 9300 ttcaagaatt tattgatcag gttgctaaaa gcgagccacc ggtcggaccg agcgcatggg 9360 acggctatat tgccgctatt acggccgctg ctgcgaatcg gtcacagaaa gatcaggaaa 9420 ctgttctcat caatgtggcc ggaacaccaa ctttttacca aaacaaaaac gcgattcatg 9480 cttagtcttg cttagacaaa atagaaagag gtaattgaaa cgatgactca aaaaacgatt 9540 aaaatcggca ttgttggttt gggacggctg ggtaaaattc atgcgacaaa cattgcgacg 9600 aagattcagc acgccaagct gcaagcggcg acaagtgttg tacccgctga actggactgg 9660 gcaaaaaagg aactcggcgt cgaagaggtc tttgaagatt ttgacgacat ggtgcaacat 9720 gcggacatcg atgctgtctt cattgtttcg ccgtcaggat ttcatcttca gcaaattgaa 9780 agcgctttaa atgctgggaa gcatgttttc agtgaaaagc caattggcct agatattgag 9840 gcaattgagc atacgcaaca ggtcattgcg caacatgcaa acttgaagtt tcagttaggc 9900 tttatgcggc ggtttgatga ctcctatcgt tatgcgaagc agttggtaga tcaaggtaag 9960 attggtgata ttaccttgat tcgcagctat agcattgatc cggcggcggg gatggcaagt 10020 ttcgttaaat ttgcaacatc tgctaatagt ggcgggttgt tcttggatat gtcgattcac 10080 gacattgatg tcattcgttg gtttaccggc aaagagattg ataaagtttg ggcgattggt 10140 cttaaccgtg cctatcctgt tctggataaa gccggcgagt tggaaacagg tgcagcctta 10200 atgcaactag aggacaaaac gatggccatt ttagtggctg ggcgtaatgc cgcgcatggc 10260 taccacgttg aaactgagat tattgggact aaagggatgt tacgcattgc tcaggtgccg 10320 gagaagaatc ttgtgacagt catgaatgag gaaggtatta tacgcccgac ttcgcaaaac 10380 ttcccggaac gctttgcaca agccttttta agtgaagaac aagcttttgt gaatagcatt 10440 ttgaataacc aggatgtcgg cattacagca gaagatggcc tgcaagggac aaaggcggca 10500 ttagctttgc aagaagcgtt tgaaaagaat gacattgttc aagtagcgtc tgtagacaaa 10560 aaggtaggtg cttaaagtga cgattgaatt gggtattgcc ccaatcggct ggacaaatga 10620 tgatatgcct gaattaggca aagaggttac atttgaacaa gccattgatg aaatgacgtt 10680 ggccggttat aaagggacag aagtcggcaa taaatatcct aaagatccga agactttgaa 10740 acactttttg gatcttagac atttgaaaat tgctagtgca tggttcagtg cttttttaac 10800 cactaaacca tacgaagaaa cagaggccgc gtttattaaa caccgagatt ttctccatgc 10860 catgggcgct aaagtgattg ttgtcgccga acaagggcat agtgttcaag gtttattaga 10920 caaatcggtt tttgacgaca aacctcactt taccgacgat gaatgggaac gtttagcaac 10980 aggattggaa cgattgggtg atcgggcccg tgaagtcggg atgcaaatcg tttatcacca 11040 tcacatgggg acgggggttc aaacaactgc ggaaatcgac cgattaatga caatgaccga 11100 cccggacaaa gtatcgctgc tattcgatac agggcatttg gtgctttctg gtgaggatcc 11160 attgaccatc tttaaccggt accaagatcg gattaagcat attcacttca aagacgttcg 11220 ccaacagcag gcagacgaag agcataaaga tcatttgagt tttttagcag gagttaaaaa 11280 tgggatgttc actgtgccag gggatggcat gattgacttc aaaccgattt gggaagctat 11340 tcaagaaagt ggttatgatg gatggattat tgttgaagct gaacaagatc cagccaaagc 11400 caatcctttt gaatatgcat taaaggcgaa gaaatacctg gatgcaacga tgaatattcc 11460 tcagtcagca taagtgtaga aaggacatgg ggaaaatggc attagtttct gcgacgtcat 11520 tagtggcacc ggcattggca gatcgttacg caattggtca tttcaatatt aatggtgctg 11580 attggttaga gacgtatctg aaagttgcac aaacgactaa gacaccgatc attgtcgcca 11640 cttccgatcg tatcattgac tttctaggcg gctttgacta tatggctcgc tacgtacggt 11700 ttatgatgca agcgctcagt gtgacagtac cagttgcttt gcatttggac catgggttat 11760 cagttgacca tgtttatcaa gcgattgatg ctggttacac gtcggtgatg tttgatggtt 11820 caaagttgcc cattggcgaa aatgtggcct taactaaaga agtcgtagca tatgcccatg 11880 cacatcatgt ttctgtcgag gccgaagttg gtagcgtagg tggtaatgag aatggactcg 11940 tcaatgggat tcgatatgca agcgttgctg acgctgttga gatggcttca acaggtattg 12000 acgcattagc cgcggcactt ggatccgttc acggtgatta cgtcggtcgg ccaaatctga 12060 attttgaacg catggccgag attgcagcgg ctactaaatt acctttagtg cttcatggtg 12120 cgtctggcat tttagatgat cagatccaac aggcgattca gttaggcact gcaaaaatca 12180 atatcaatac agaagttaat acagtttgga cgagtgctgt gaccaaagcc ctgcaagcca 12240 aacgttccaa tcatgacccg caaccaattt taactgctgg taagcaagca atcgcgtatt 12300 tggtagaagc gaagatgaag gcatttcatg tgttagggaa aagtactcgc ctatcttcta 12360 tgagttgatg tgaacaacaa atttatccaa gagggagaga ttaagatgcc actcattcgt 12420 tttgatatga tcaaaggccg atcacctgaa gagattaagg acattttaca aattgctcac 12480 gaggtcatgg tagcagcttt tgacgtgcca ccacgagatc gttatcagat cgttcatcaa 12540 catgagcctt atgaaatggt cgtcgaggac acaggattag atattccaag aacagatagg 12600 gtcattgtca tatcgattgt gagtcgagtc cgaaccattc gacagctaaa gaaattttat 12660 caagatttag cagataaatt ggaaactgcc ggattagtgg acaagaatga cctcatgatt 12720 aacgtttcat tcaatgatga tcaaggctgg agcttcggac aagggaaggc acagttcctt 12780 gaaggtagtc tgtaacgaca attgaattag aagcaaacgc aatatcgttg accacttacg 12840 caataaatct gaattggtta cgatcagtgt tcaacggatt tctaaggcaa 12890 // |
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