EBI Dbfetch

ID   CR931673; SV 1; linear; genomic DNA; STD; PRO; 21819 BP.
XX
AC   CR931673;
XX
DT   30-JUN-2005 (Rel. 84, Created)
DT   18-SEP-2008 (Rel. 97, Last updated, Version 5)
XX
DE   Streptococcus pneumoniae strain 4593/40 (serotype 18c).
XX
KW   .
XX
OS   Streptococcus pneumoniae
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
XX
RN   [1]
RP   1-21819
RX   DOI; 10.1371/journal.pgen.0020031
RX   PUBMED; 16532061.
RA   Bentley S.D., Aanensen D.M., Mavroidi A., Saunders D., Rabbinowitsch E.,
RA   Collins M., Donohoe K., Harris D., Murphy L., Quail M.A., Samuel G.,
RA   Skovsted I.C., Kaltoft M.S., Barrell B., Reeves P.R., Parkhill J.,
RA   Spratt B.G.;
RT   "Genetic analysis of the capsular biosynthetic locus from all 90
RT   pneumococcal serotypes";
RL   Plos Genet. 2(3):e31-e31(2006).
XX
RN   [2]
RP   1-21819
RA   Bentley S.D.;
RT   ;
RL   Submitted (09-DEC-2004) to the EMBL/GenBank/DDBJ databases.
RL   Submitted on behalf of the Pathogen Sequencing Unit, Sanger Institute,
RL   Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, E-mail:
RL   sdb@sanger.ac.uk
XX
CC   NOTE: This sequence was generated from a PCR product representing the
CC   region from dexB to aliA and is not necessarily responsible for the
CC   expressed capsule serotype. For a detailed description of how CDS
CC   products were predicted see the associated publication.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..21819
FT                   /organism="Streptococcus pneumoniae"
FT                   /strain="4593/40"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:1313"
FT   CDS             <1..134
FT                   /codon_start=3
FT                   /transl_table=11
FT                   /gene="dexB"
FT                   /locus_tag="SPC18C_0001"
FT                   /db_xref="UniProtKB/TrEMBL:Q4K1T1"
FT                   /protein_id="CAI33572.1"
FT                   /translation="SNEEQDLTVEGKVKSVLIENTAAKEVLEKQVLAPWDAFCVELL"
FT   CDS             293..466
FT                   /pseudo
FT                   /transl_table=11
FT                   /gene="aliB"
FT                   /locus_tag="SPC18C_0002"
FT                   /product="putative oligopeptide-binding protein AliB
FT                   (pseudogene)"
FT                   /db_xref="PSEUDO:CAI33573.1"
FT   CDS             complement(459..980)
FT                   /pseudo
FT                   /transl_table=11
FT                   /gene="tnp"
FT                   /locus_tag="SPC18C_0003"
FT                   /product="putative IS630-Spn1 transposase (fragment)"
FT                   /note="member of homology group 4"
FT   CDS             1203..2648
FT                   /transl_table=11
FT                   /gene="wzg"
FT                   /locus_tag="SPC18C_0004"
FT                   /product="integral membrane regulatory protein Wzg"
FT                   /note="member of homology group 0"
FT                   /db_xref="GOA:Q9AH98"
FT                   /db_xref="InterPro:IPR004474"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH98"
FT                   /protein_id="CAI33575.1"
FT                   /translation="MSRRFKKSRSQKVKRSVNIVLLTIYLLLVCFLLFLIFKYNILVFR
FT                   YLNLVVTVLVLLVALIGLLLIIYKKAEKFTIFLLVFSILVSSVSLFAVQQFVGLTNRLN
FT                   ATSNYSEYSISVAVLADSEIENVTQLTSVTAPTGTDNENIQKLLADIKSSQNTDLTVDQ
FT                   SSSYLAAYKSLIAGDTKAIVLNSVFENIIESEYPDYASKIKKIYTKGFTKKVEAPKTSK
FT                   NQSFNIYVSGIDTYGPIGSVSRSDVNILMTVNRDTKKILLTTTPRDAYVPIADGGNNKK
FT                   DKLTHAGIYGVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALH
FT                   GKFHFPVGNVHLDSEQALGFVRGRYSLADGDRDRGRNQQKVIVAIIQKLTSTEVLKNYS
FT                   SILQGLQDSLQTNMPIETMIDLVNTQLESGGNYKVNSQDLKGTGRMDLPSYAMPDSNLY
FT                   VMEIDDSSLAVAKAAIQDVMEGR"
FT   misc_feature    1203..1319
FT                   /note="Signal peptide predicted for SPC0914 by SignalP 2.0
FT                   HMM (Signal peptide probability 0.996) with cleavage site
FT                   probability 0.577 between residues 39 and 40"
FT   misc_feature    1407..1754
FT                   /note="HMMPfam hit to PF02916, DNA polymerase processivity
FT                   factor, score 2.1e-64"
FT   misc_feature    1932..2375
FT                   /note="HMMPfam hit to PF03816, Cell envelope-related
FT                   transcriptional a, score 8.8e-69"
FT   CDS             2650..3381
FT                   /transl_table=11
FT                   /gene="wzh"
FT                   /locus_tag="SPC18C_0005"
FT                   /product="protein-tyrosine phosphatase Wzh"
FT                   /EC_number="3.1.3.48"
FT                   /note="member of homology group 1"
FT                   /db_xref="GOA:Q4K157"
FT                   /db_xref="InterPro:IPR016667"
FT                   /db_xref="UniProtKB/TrEMBL:Q4K157"
FT                   /protein_id="CAI33576.1"
FT                   /translation="MIDIHSHIVFDVDDGPKSREESKALLAEAYRQGVRTIVSTSHRRK
FT                   GMFETPEEKIAENFLQVREIAKEVADDLVIAYGAEIYYTMDALEKLEKKEIPTLNDSRY
FT                   ALIEFSMHTSYRQIHTGLSNILMLGITPVIAHIERYDALENNEKRVRELIDMGCYTQIN
FT                   SYHVSKPKFFGEKYKFMKKRARYFLERDLVHVIASDMHNLDSRPPYMQQAYDIIAKKYG
FT                   AKKAKELFVDNPIKIIMDQLI"
FT   misc_feature    2653..3261
FT                   /note="HMMPfam hit to PF02811, PHP domain, score 1.1e-38"
FT   CDS             3390..4082
FT                   /transl_table=11
FT                   /gene="wzd"
FT                   /locus_tag="SPC18C_0006"
FT                   /product="capsular polysaccharide biosynthesis protein Wzd"
FT                   /note="member of homology group 2"
FT                   /db_xref="GOA:Q9AH96"
FT                   /db_xref="InterPro:IPR005829"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH96"
FT                   /protein_id="CAI33577.1"
FT                   /translation="MQDQNALEIDVFQLFRALWKRKLVILLVAIITSSVAFAYSTFVIK
FT                   PEFTSTTRIYVVNRNKEEKSGLTNQDLQAGSYLVKDYREIILSQDVLEEVVSDLKLDLT
FT                   PKGLANKIKVTVPVDTRIVSISVNDRVPEEASRIANSLRKVAAQKIISITRVSDVTTLE
FT                   EARPAISPSSPNIKRNTLIGFLAGVIGTSVIVLLLELLDTRVKRPEDIENTLQMTLLGV
FT                   VPNLGKLK"
FT   misc_feature    3408..3824
FT                   /note="HMMPfam hit to PF02706, Chain length determinant
FT                   protein, score 4.5e-53"
FT   misc_feature    3930..4007
FT                   /note="PS00217 Sugar transport proteins signature 2."
FT   CDS             4092..4775
FT                   /transl_table=11
FT                   /gene="wze"
FT                   /locus_tag="SPC18C_0007"
FT                   /product="tyrosine-protein kinase Wze"
FT                   /EC_number="2.7.1.112"
FT                   /note="member of homology group 3"
FT                   /db_xref="GOA:Q9AH95"
FT                   /db_xref="InterPro:IPR005702"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH95"
FT                   /protein_id="CAI33578.1"
FT                   /translation="MPTLEIAQKKLEFIKKAEEYYNALCTNIQLSGDKLKVISVTSVNP
FT                   GEGKTTTSINIAWSFARAGYKTLLIDGDTRQSVMSGVFKSREKITGLTEFLSGTADLSH
FT                   GLCDTNIENLFVVQSGSVSPNPTALLQSKNFNDMIETLRKYFDYIIVDTPPIGIVIDAA
FT                   IITQKCDASILITATGEVNKRDVQKAKQQLEQTGKLFLGVVLNKLDISVDKYGAYGSYG
FT                   NYGKK"
FT   CDS             4791..6158
FT                   /transl_table=11
FT                   /gene="wchA"
FT                   /locus_tag="SPC18C_0008"
FT                   /product="undecaprenylphosphate glucosephosphotransferase
FT                   WchA (initial sugar transferase)"
FT                   /note="member of homology group 5"
FT                   /db_xref="GOA:Q9AH94"
FT                   /db_xref="InterPro:IPR017475"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH94"
FT                   /protein_id="CAI33579.1"
FT                   /translation="MDEKGLKIFLAVLQSIIVILLIYFLNFVRETELERSSMVILYLLH
FT                   FFVFYFSSYGNNFFKRGYLVEFNSTIRYIFFFAIAISVLNLFIAERFSISRRGMVYFLT
FT                   LEGISLYLLNFLVKKYWKHVFFNLKNSKKILLLTVTKNMEKVLDKLLESDEPSWKLVAV
FT                   SVLDKSDFQHDKIPVIEKEKIIEFATHEVVDEVFVNLPGESYDIGEIISRFETMGIDVT
FT                   VNLKAFDKNFGRNKQIHEMVGLDVVTFSTNFYKTSHVISKRILDICGATIGLILFAIAS
FT                   LVLVPLIRKDGGPAIFAQTRIGKNGRHFTFYKFRSMRIDAEAIKEQLMDQNTMQGGMFK
FT                   IDNDPRVTKIGRFIRKTSLDELPQFWNVFIGDMSLVGTRPPTVDEYDQYTPEQKRRLSF
FT                   KPGITGLWQISGRSKITDFDAVVKLDVAYIDNWTIWKDIEILLKTVKVVFMRDGAK"
FT   misc_feature    5574..6155
FT                   /note="HMMPfam hit to PF02397, Bacterial sugar transferase,
FT                   score 2.3e-146"
FT   CDS             6189..7361
FT                   /transl_table=11
FT                   /gene="wchF"
FT                   /locus_tag="SPC18C_0009"
FT                   /product="putative rhamnosyl transferase WchF"
FT                   /note="member of homology group 15"
FT                   /db_xref="GOA:Q9AH93"
FT                   /db_xref="InterPro:IPR015393"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH93"
FT                   /protein_id="CAI33580.1"
FT                   /translation="MKKSVYIIGSKGIPAKYGGFETFVEKLTAFQQDKAIQYYVACMRE
FT                   NSAKSGTTEDVFEHNGAICYNVDVPNIGPARAIAYDIAAINRAIEIAKENKDEAPIFYI
FT                   LACRIGPFIHGIKKKIQAIGGTLLVNPDGHEWLRAKWSAPVRRYWKISEGLMVKHADLL
FT                   VCDSKNIEKYIQEDYIQYQPKTTYIAYGTDTTRSTLNSSDEKVRAWFKEKNVSENEYYL
FT                   VVGRFVPENNYESMIRGFLASSSKKDFVLITNVEQNKFYNQLLASTGFDKDPRVKFVGT
FT                   VYDQELLKYIRENAFAYFHGHEVGGTNPSLLEALASTKLNLLLDVGFNREVGEQSAIYW
FT                   KKDELSQVIEKVEQFDAKMIDELDRQSNQRIGDYFTWEKIVTDYEKLFKK"
FT   CDS             7358..8629
FT                   /transl_table=11
FT                   /gene="wciU"
FT                   /locus_tag="SPC18C_0010"
FT                   /product="putative glycosyl transferase"
FT                   /note="member of homology group 59"
FT                   /db_xref="GOA:Q9AH92"
FT                   /db_xref="InterPro:IPR001296"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH92"
FT                   /protein_id="CAI33581.1"
FT                   /translation="MKILHYTLGFQPQRTGGLVKYAEDLMIEQIAQGYQVAALYPGRIK
FT                   FFSKEIEIIKATSRQFECYELLNSLPMALFGGISDPTAFLTPCDKNVYRTFLEKVQPDI
FT                   IHIHSFMGLHKEFLEIAKNLNIRVVFTSHDYYGLAPVPHFYFNGVDYSDKNTNLTWNIM
FT                   SSNALSVKKLRLFQVSFYPTIRKLLKLLGKNPKSKKNLVIRDVIEEQDYSDLRYYYNEM
FT                   FHLIDGYLFNSRLAKKVYEINEIKSANSIVLSITNSSINHHQRLTTANNKIRVAYIGPD
FT                   EEYKGYFDFIDFVETLDRESYEVATYGHLPNEECPSFIEQKGYFTKEMIDSVYENIDIL
FT                   IVPSKWKETFGLITVEALSYGVNVFVSENVGSKDLFPETHVFKDKEDLLAKIINNQLKK
FT                   IPLKTIEEHVEEVIGYYKQVRSNN"
FT   misc_feature    8132..8602
FT                   /note="HMMPfam hit to PF00534, Glycosyl transferases group,
FT                   score 0.00023"
FT   CDS             8635..9699
FT                   /transl_table=11
FT                   /gene="wciV"
FT                   /locus_tag="SPC18C_0011"
FT                   /product="putative glycosyl transferase"
FT                   /note="member of homology group 91"
FT                   /db_xref="GOA:Q9AH91"
FT                   /db_xref="InterPro:IPR001173"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH91"
FT                   /protein_id="CAI33582.1"
FT                   /translation="MIKDMSCPEISVIVPVYNVERYLRQCMDSLINQTYRDFEIILVND
FT                   GSTDSSGVLCEDWAKKDERIHVVHKKNEGLGFARNTGVEHAKGKYITFVDSDDYVSLDM
FT                   LQTLYNAVQEYDVEVVYSAGYYRSFSNGEIKKTDVETKKPQLFEGGDVASKLLPDVISA
FT                   PPEYPNDGKVGVSAWKVLYEANLFKEKGLLFHSEREFISEDAIFQIDCLKLATSALVIP
FT                   DILYYYRENFGSLSMKYKEERFELDKILYNEQLKRVEGLPNQEILEERIERILIANIRL
FT                   CIFQESLYKSSRIHKRLQRIRQICKDPISKSVLRHYPIHRLPFTKRLICVLAKYNMSLL
FT                   LLVLTSLKYRNRSV"
FT   misc_feature    8665..9207
FT                   /note="HMMPfam hit to PF00535, Glycosyl transferase family,
FT                   score 2.6e-45"
FT   CDS             9705..10616
FT                   /transl_table=11
FT                   /gene="wciW"
FT                   /locus_tag="SPC18C_0012"
FT                   /product="putative glycosyl transferase"
FT                   /note="member of homology group 92"
FT                   /db_xref="GOA:Q9AH90"
FT                   /db_xref="InterPro:IPR008441"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH90"
FT                   /protein_id="CAI33583.1"
FT                   /translation="MGMNIEKLKLSFKNGTFFPVVIHALRNRWPLWWIRSKAIREVQLE
FT                   DRAYRILKKKYGSLISNSFDKSYLSEEVPKQIWICWFQGMENAPELVKSCYRSLKKQFP
FT                   EYVITVISSENISEYVEISDIIYKKWGNGVIGNAHFSDILRVELLRKFGGIWIDSTVYC
FT                   TGITTIETIEKNTFFMYKSLYSVEERISSSNWMIASVPNHPFMVTMSTLLQSYWSKEVI
FT                   AIHYYLFHILFTIMIESLSELWQLVPTYTNATPHIMVDELNNVFSKERYQQLCQISDFH
FT                   KLNYKKNYNDKSESLYSHLLNQ"
FT   misc_feature    9786..10604
FT                   /note="HMMPfam hit to PF05704, Capsular polysaccharide
FT                   synthesis protein, score 1.1e-149"
FT   CDS             10628..12085
FT                   /transl_table=11
FT                   /gene="wzx"
FT                   /locus_tag="SPC18C_0013"
FT                   /product="flippase Wzx"
FT                   /note="member of homology group 7"
FT                   /db_xref="GOA:Q4K149"
FT                   /db_xref="InterPro:IPR002797"
FT                   /db_xref="UniProtKB/TrEMBL:Q4K149"
FT                   /protein_id="CAI33584.1"
FT                   /translation="MPNLKKNIVYNVLYQILAVIVPFITSPYLARVLGAEQIGVYSFTY
FT                   SIAFYFMILSMLGISNYGNRTIAQVRTSREHLNQEFSNIYAVQLTCSLVMTVSYLIYAT
FT                   VFVNSFQIVAYIQVLHVLSYATDVSWFFYGLEEFRITVARNSFVKLLTLISIFTFVKSP
FT                   NDIYLYTFIMAGSTLLGQLITWQFLLKQVNFVRPNLGKIKKHMKPIIILFFPVLAVSIF
FT                   SFLDKIMLGMYSSLKETAFYENSDKIISIPKALIQAFGAVMLPRTVHLLSIGDEQKSLE
FT                   YVDKTMWVVLVITMGCAFGLAGVSATFAPVYWGEEFRASSQIIAGMTPALVFSAFGNVI
FT                   RTQFLIPRSFDKEYTVSLLYGAVVNILINILLIPKMGAMGAVIGIIVAELVLCCYQTWI
FT                   ARNYLHIREYLINAGILFLIGSVMYMVLILISSILPTSLLTLIIEIIVGAFIYISLLVL
FT                   YIFSSKNRVIIGLRTNFLEHTHLFKRK"
FT   misc_feature    10637..11440
FT                   /note="HMMPfam hit to PF01943, Polysaccharide biosynthesis
FT                   protein, score 4.7e-56"
FT   CDS             12088..13362
FT                   /transl_table=11
FT                   /gene="wzy"
FT                   /locus_tag="SPC18C_0014"
FT                   /product="oligosaccharide repeat unit polymerase Wzy"
FT                   /note="member of homology group 93"
FT                   /db_xref="InterPro:IPR007016"
FT                   /db_xref="UniProtKB/TrEMBL:Q4K148"
FT                   /protein_id="CAI33585.1"
FT                   /translation="MKFKFNPIAILYILLVYLELATDRQHLYPVTYMTKYYIGILIIVL
FT                   FVLLLVGRGKLIFVNKKLLYLAKILAIPTIVLFLYSVLLDVMNPVEFNGYFSRLSSTTI
FT                   FGLLAIFQAIVVFQFFGQKVVDYTFTAISLSYLTSIIVAFRQGGLSQFILILTDDSFNG
FT                   SVLEMHEVAPITALFILYYLYKYFIKENSFSSVFYNILIALIILFLSLKRIVLLSVLII
FT                   IPVFLVIYWYDKKVSKLGKERKILSLLNIFSLIFITGIFLYVYSVKSDFIYTFIQEHNI
FT                   NSMARTDLWKGVESTYNFAPIFMGRGIGFVTKWMDNNWMTLNINGLTGTMGIHNDILKY
FT                   YIEIGFVGLFIYFYTLLYRNAKRIFVKIGHKESFIYFVLIMFQMLIWFTDNISIYHNFL
FT                   WILNLLLFSLTNSDTELENLDFKNF"
FT   misc_feature    12925..13137
FT                   /note="HMMPfam hit to PF04932, O-Antigen Polymerase, score
FT                   7.3e-10"
FT   CDS             13416..14417
FT                   /transl_table=11
FT                   /gene="wciX"
FT                   /locus_tag="SPC18C_0015"
FT                   /product="putative acetyl transferase"
FT                   /note="member of homology group 107"
FT                   /db_xref="GOA:Q9AH87"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH87"
FT                   /protein_id="CAI33586.1"
FT                   /translation="MKTDARTKKRENETLYILKVWATFSVIAIHFGFLGQIGVFYKVLA
FT                   RFAVPLFFMISGFYSFSISEEKLKKRIKNLSLLIISSTSFYFLLDVFLQLTQGNLRVVF
FT                   ERFTFNNIFNFLVFNQISALIGSLATPLWFLYALLYVYIYLFFSNKKWIFNTILTVIIL
FT                   CCSFIIELKANSALFYRNFLFMGVPFFSFGMYFAQIQRKIINYKHFKELFIIGIMISGF
FT                   LTLIEYTFLGANFELYVSSVIISCMLMVFSIKYPQLWTLDFAVNIAKKNATFIYISHQF
FT                   VILLFKTYVRDGIAYKIGTFLIFLACVIMSIIFNYIVDIISRCCIKEKQDII"
FT   CDS             14414..15574
FT                   /transl_table=11
FT                   /gene="wciY"
FT                   /locus_tag="SPC18C_0016"
FT                   /product="putative glycerol phosphotransferase"
FT                   /note="member of homology group 78"
FT                   /db_xref="GOA:Q4K146"
FT                   /db_xref="InterPro:IPR007554"
FT                   /db_xref="UniProtKB/TrEMBL:Q4K146"
FT                   /protein_id="CAI33587.1"
FT                   /translation="MKFYIKNLLKKVFTLPLHLLPIQSNKIIFDNFGGRGFGDNPKYIL
FT                   EELVSREKNLDLVWVTKDREISIPEGVRVVKYGSYRSFYEWLTARVWVDNIRNSDRPWK
FT                   RKGQIYLQTWHGSDGVKLIEKSVAGNLKKTYLRMAKYDGKITDGIVSSRHFQTLGMQNN
FT                   FWLAENVEFLEFGLPRNDDFFKSEKIKTTNIKFRTLFDIDLDELVVLYMPTFRDDGSLN
FT                   AYNLDYSKLIHVFQNKFRKNVKILVRFHPNVDSSFINLQDTDCINVSTYSNPQDLMMSA
FT                   DVMITDYSSASIDFMLLNRPVFLYLPDYQSYVNDRPLDDNFDKLPFPRAYHNNELTEII
FT                   RDFERSKYDEKVRLYELEDVRFDRGKASVQCANWIEEKIKNNKVID"
FT   misc_feature    14999..15544
FT                   /note="HMMPfam hit to PF04464,
FT                   CDP-Glycerol:Poly(glycerophosphate) gl, score 2.3e-68"
FT   CDS             15616..16008
FT                   /transl_table=11
FT                   /gene="gct"
FT                   /locus_tag="SPC18C_0017"
FT                   /product="CDP-glycerol-1-phosphate biosynthetic protein
FT                   Gct"
FT                   /note="member of homology group 28"
FT                   /db_xref="GOA:Q9AH85"
FT                   /db_xref="HSSP:1COZ"
FT                   /db_xref="InterPro:IPR014729"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH85"
FT                   /protein_id="CAI33588.1"
FT                   /translation="MKRVITYGTFDLLHYGHINLLKRAKQLGDYLIVVVSSDEFNLKEK
FT                   NKVCYFNYEHRKNLVEAIRYVDLVIPETSWEQKKSDVKDYHIDTFVMGDDWKGKFDYLE
FT                   EEGVEVVYLPRTKEISTTKIKEDLSE"
FT   misc_feature    15628..15996
FT                   /note="HMMPfam hit to PF01467, Cytidylyltransferase, score
FT                   4.8e-29"
FT   CDS             join(16105..16215,16247..16465,16476..16649)
FT                   /pseudo
FT                   /transl_table=11
FT                   /gene="HG94"
FT                   /locus_tag="SPC18C_0018"
FT                   /product="hypothetical protein (pseudogene)"
FT                   /note="member of homology group 94"
FT   CDS             16848..17717
FT                   /transl_table=11
FT                   /gene="rmlA"
FT                   /locus_tag="SPC18C_0019"
FT                   /product="glucose-1-phosphate thymidylyltransferase RmlA"
FT                   /EC_number="2.7.7.24"
FT                   /note="member of homology group 10"
FT                   /db_xref="GOA:Q9AH84"
FT                   /db_xref="HSSP:1H5R"
FT                   /db_xref="InterPro:IPR005907"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH84"
FT                   /protein_id="CAI33590.1"
FT                   /translation="MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLAG
FT                   IRDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDSVAL
FT                   ILGDNIYHGPGLSKMLQKAAKKEKGATVFGYHVKDPERFGVVEFDENMNAISIEEKPEQ
FT                   PCSNYAVTGLYFYDNDVVEIAKSIKPSPRGELEITDVNKAYLDRGDLSVELMGRGFAWL
FT                   DTGTHESLLEASQYIETVQRMQNVQVANLEEIAYRMGYISREDVLTLAQPLKKNEYGQY
FT                   LLRLIGEV"
FT   misc_feature    16851..17567
FT                   /note="HMMPfam hit to PF00483, Nucleotidyl transferase,
FT                   score 2.2e-120"
FT   CDS             17718..18311
FT                   /transl_table=11
FT                   /gene="rmlC"
FT                   /locus_tag="SPC18C_0020"
FT                   /product="dTDP-4-keto-6-deoxy-D-glucose 3,5-epimerase RmlC"
FT                   /EC_number="5.1.3.13"
FT                   /note="member of homology group 11"
FT                   /db_xref="GOA:Q9AH83"
FT                   /db_xref="HSSP:1NXM"
FT                   /db_xref="InterPro:IPR014710"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH83"
FT                   /protein_id="CAI33591.1"
FT                   /translation="MTDNFFGKTLAARKVEAIPGMLEFDIPVHGDNRGWFKENFQKEKM
FT                   LPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISVADGGKVLGSWVDLREGET
FT                   FGNTYQTVIDASKGIFVPRGVANGFQVLSDTVSYSYLVNDYWALELKPKYAFVNYADPS
FT                   FGIEWENIAEAEVSEADKHHPLLKDVKPLKKEDL"
FT   misc_feature    17754..18284
FT                   /note="HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose
FT                   3,5-epimerase, score 1.2e-15"
FT   CDS             18324..19373
FT                   /transl_table=11
FT                   /gene="rmlB"
FT                   /locus_tag="SPC18C_0021"
FT                   /product="dTDP-D-glucose 4,6-dehydratase RmlB"
FT                   /note="member of homology group 8"
FT                   /db_xref="GOA:Q9AH82"
FT                   /db_xref="HSSP:1KEP"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH82"
FT                   /protein_id="CAI33592.1"
FT                   /translation="MTEYKNIIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNR
FT                   ANIEEVLGNRVELVIGDIADAELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFI
FT                   GTYTLLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSS
FT                   TKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGK
FT                   NVRDWIHTNDHSSGVWTILTKGQIGETYLIGADGEKNNKEVLELILKEMGQATDAYDHV
FT                   TDRAGHDLRYAIDASKLRDELGWKPEFTNFEAGLKATIKWYTDNQEWWKAEKEAVEANY
FT                   AKTQEIITV"
FT   misc_feature    18339..19295
FT                   /note="HMMPfam hit to PF04321, RmlD substrate binding
FT                   domain, score 5.4e-05"
FT   misc_feature    18342..19082
FT                   /note="HMMPfam hit to PF01370, NAD dependent
FT                   epimerase/dehydratase f, score 3.5e-78"
FT   misc_feature    18342..19178
FT                   /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
FT                   protein, score 0.0028"
FT   misc_feature    18345..19157
FT                   /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
FT                   dehydrogenase/i, score 7.5e-06"
FT   CDS             19439..20290
FT                   /transl_table=11
FT                   /gene="rmlD"
FT                   /locus_tag="SPC18C_0022"
FT                   /product="dTDP-4-keto-L-rhamnose reductase RmlD"
FT                   /EC_number="1.1.1.133"
FT                   /note="member of homology group 9"
FT                   /db_xref="GOA:Q9AH81"
FT                   /db_xref="HSSP:1N2S"
FT                   /db_xref="InterPro:IPR016040"
FT                   /db_xref="UniProtKB/TrEMBL:Q9AH81"
FT                   /protein_id="CAI33593.1"
FT                   /translation="MILITGANGQLGTELRYLLDERNEEYVAVDVAKMDITNEEMVEKV
FT                   FEEVKPTLVYHCAAYTAVDAAEDEGKELDFAINVTGTKNVAKASEKHGATLVYISTDYV
FT                   FDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKNFVF
FT                   TMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDTTWYD
FT                   FAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQEFYKQE
FT                   VR"
FT   misc_feature    19439..20287
FT                   /note="HMMPfam hit to PF04321, RmlD substrate binding
FT                   domain, score 4.3e-146"
FT   misc_feature    19442..20071
FT                   /note="HMMPfam hit to PF01370, NAD dependent
FT                   epimerase/dehydratase f, score 2e-18"
FT   misc_feature    19442..20083
FT                   /note="HMMPfam hit to PF02719, Polysaccharide biosynthesis
FT                   protein, score 0.00011"
FT   misc_feature    19445..20173
FT                   /note="HMMPfam hit to PF01073, 3-beta hydroxysteroid
FT                   dehydrogenase/i, score 3.6e-08"
FT   CDS             join(20335..20430,20460..20975,20951..21454)
FT                   /pseudo
FT                   /transl_table=11
FT                   /gene="glf"
FT                   /locus_tag="SPC18C_0023"
FT                   /product="UDP-galactopyranose mutase Glf"
FT                   /EC_number="5.4.99.9"
FT                   /note="member of homology group 6"
FT   misc_feature    join(20787..20951,20975..21394)
FT                   /note="HMMPfam hit to PF03275, UDP-galactopyranose mutase,
FT                   score 6.9e-102"
FT   CDS             21772..>21819
FT                   /transl_table=11
FT                   /gene="aliA"
FT                   /locus_tag="SPC18C_0024"
FT                   /db_xref="UniProtKB/TrEMBL:Q4JZ89"
FT                   /protein_id="CAI33595.1"
FT                   /translation="MMKSSKLLALAGVTLL"
XX
SQ   Sequence 21819 BP; 7209 A; 3153 C; 4317 G; 7140 T; 0 other;
     tgtccaatga agagcaagac ttgacagtag aaggaaaagt caaatctgtc ttgattgaaa        60
     acactgcggc taaagaagta cttgaaaaac aggtcttggc tccatgggat gctttctgtg       120
     tggaattact ataaatattt tttgcagaaa aatttaaaat tgaaatcata taaaaacaag       180
     ggaggactgt ataaaagaca gaaatccttt gttttttata accaaggttt ataaactttc       240
     attctcgaaa ttcaattaac tttacaaatt cccactatta aggagaaaga aaatgaacat       300
     aaagaagcgt gtccttagtg caggtctgac ttttgcatct gctttgcttt tagctgcttg       360
     cgaccaatca ggttcagata caaaaactta ctcatcaacc tttagtggaa atccaactac       420
     atttaactat ctattagact attacgctga taatatagtc aattgaaaca agagaaagac       480
     aaaagagcct cgtaaaaggt attgcaactt ggtaatacct ttttgaggtg ctttttgata       540
     tgagcccatg ttttctcaat aggattgtac tcaggtgagt agggaggaag aggtaaaagt       600
     ttatgcccaa actcttcgca taaaagttct agcttcccca ttctatggaa tcttgcatta       660
     tccataataa taaccgatgg tgtggttaat gttggtaaga aaaacttctg aaaccaagct       720
     tcaaaaaagt cgctcgtcat cgtctcttcg taagtcattg gaacgattaa ctcaccattt       780
     gttagacctg caaccaaaga aatcctctga tatcttcttc cagatacttt gcctcttctt       840
     aactgacctt ttaatgagcg accatattct cgataaaaat aagtatcgaa tcctgtttca       900
     tcaatctaaa caggtgctag gtgctttaaa ctattaaaat tcttaagaaa taaggctact       960
     ttttctgggt cttgttcata attagattga aactagaata gtacacctct gcttctaaaa      1020
     cattgttaga aatcgatttg actgtcctga tcgatttgtc atgttcttat ttcattttac      1080
     tatatttttg tttcgcggga agtctactaa gatacttaaa gatgcagata gtaaaaaaag      1140
     atgtagacat taccgtaaaa aagtgatata atcgtatgat attgaatgta taggtgttaa      1200
     tcttgagtag acgttttaaa aaatcacgtt cacagaaagt gaagcgaagt gttaatatag      1260
     ttttactgac tatttattta ttgttagttt gttttttatt gttcttaatc tttaagtaca      1320
     atatccttgt ttttagatat cttaatctag tggtaactgt gttagtccta ctagttgcct      1380
     tgatagggct actcttgatt atctataaaa aagctgaaaa gtttactatt tttctgttgg      1440
     tgttctctat ccttgtcagc tctgtgtcgc tctttgcagt acagcagttt gttggactga      1500
     ccaatcgttt aaatgcgact tctaattact cagaatattc aatcagtgtc gctgttttag      1560
     cagatagtga gatcgaaaat gttacgcaac tgacgagtgt gacagcaccg actgggactg      1620
     ataatgaaaa tattcaaaaa ctattagctg atatcaagtc aagtcagaat accgatttga      1680
     cggtcgacca gagttcgtct tacttggcag cttacaagag tttgattgca ggtgacacca      1740
     aggccattgt cttaaatagt gtctttgaaa atatcatcga gtcagagtat ccagactacg      1800
     catcgaagat aaaaaagatt tataccaagg gattcactaa aaaagtagaa gctcctaaga      1860
     cgtctaagaa tcagtctttc aatatctatg ttagtggaat tgacacctat ggtcctattg      1920
     gttcggtgtc gcgatcagat gtcaatatct tgatgactgt caatcgagat accaagaaaa      1980
     tcctcttgac cacaacgccg cgtgatgcct atgtaccaat cgcagatggt ggaaataata      2040
     aaaaagataa attgactcac gcgggcattt atggagttga ttcatccatt cacaccttag      2100
     aaaatctcta tggagtggat atcaattact atgtgcgatt gaacttcact tctttcttga      2160
     aaatgattga cttattggga ggggtagatg ttcataatga tcaagagttt tcagctctac      2220
     atgggaagtt ccatttccca gtagggaatg tccatctaga ctctgagcag gctctaggtt      2280
     ttgtacgtgg acgctactca ctagccgatg gagaccgtga ccgtggtcgc aaccaacaaa      2340
     aggtcattgt agcaattatt cagaagttaa cttctacaga ggttttgaaa aactatagta      2400
     gtattcttca aggattgcag gattctcttc aaacaaatat gccgattgag actatgatag      2460
     atttagtgaa tactcagttg gaaagtggag ggaattataa agtaaattct caagatttaa      2520
     aagggacagg tcggatggat cttccttctt atgcaatgcc agacagtaac ctctatgtga      2580
     tggaaataga tgatagtagt ttagctgtag ctaaagcagc tatacaggac gtgatggagg      2640
     gtagatgaaa tgatagatat ccattcgcat atcgtttttg atgtagatga cggtcccaag      2700
     tcaagagagg aaagcaaggc tctcttggca gaagcctaca ggcagggggt gcgaaccatt      2760
     gtctctacct ctcaccgtcg caagggcatg tttgaaactc cggaagagaa gatagcagaa      2820
     aactttcttc aggttcggga aattgcaaaa gaagtagcag atgatttagt cattgcttat      2880
     ggcgcagaga tatactatac tatggatgct ctagaaaagc tagaaaaaaa agaaattcct      2940
     acccttaatg atagtcgtta tgctttgatt gagtttagca tgcatacttc ctatcgtcag      3000
     attcatacgg gattgagcaa tattttgatg ttgggaatca cgccagtaat tgctcatatt      3060
     gaacgttatg atgctttaga gaataacgaa aaacgtgttc gtgaactgat tgatatgggg      3120
     tgctatactc agataaatag ttatcatgtt tcaaaaccta agttctttgg tgaaaaatat      3180
     aaattcatga aaaagagagc tcggtatttt ttggaacgtg atttagttca tgtcattgca      3240
     agtgacatgc acaatttaga cagtagacct ccatatatgc aacaggcata tgatatcatt      3300
     gctaagaaat atggagcgaa aaaagcgaaa gaactttttg tagataatcc cataaaaatt      3360
     ataatggatc aattaattta ggagaaaata tgcaagatca aaacgctttg gaaatcgatg      3420
     tatttcaact attcagagct ttatggaaaa gaaagttggt tattttatta gtggcaatta      3480
     taacttcttc agttgctttt gcctacagta cttttgttat caaacctgag tttactagta      3540
     cgactcggat ttatgtagtt aaccgtaata aggaagagaa gtctggttta accaatcaag      3600
     acttgcaggc aggatcatac ttggttaaag actatcgtga aattatccta tcgcaggatg      3660
     ttttggagga agttgtttct gatttgaaac tagatttgac gccaaaaggt ttggctaata      3720
     aaattaaagt gacagtacca gttgataccc gtattgtctc tatttcagtt aatgatcgag      3780
     ttcctgaaga ggcaagccgt atcgctaact ctttgagaaa agtagctgct caaaaaatta      3840
     tcagtattac tcgtgtttct gatgtgacaa cactggagga ggcaagaccg gcgatatcgc      3900
     cgtcttcgcc aaatattaaa cgcaatacac taattggttt tttggcaggg gtgattggaa      3960
     ctagtgttat agttcttctt cttgaacttt tggacactcg tgtgaaacgt ccggaagata      4020
     tcgaaaatac attgcagatg acacttttgg gagttgtacc aaacttaggt aagttgaaat      4080
     aggagagaag gatgccgaca ttagaaatag cacaaaaaaa actggagttc attaagaagg      4140
     cagaagaata ttacaatgcc ttgtgtacaa atatacagtt gagcggagat aaactaaaag      4200
     taatttccgt tacttctgtt aaccctgggg aaggaaaaac aactacttcc ataaatatag      4260
     catggtcgtt tgcgcgtgca ggctataaaa ctcttttgat cgatggcgat actcgacaat      4320
     cagttatgtc aggagttttt aaatctcgtg aaaaaattac agggctaaca gaatttttat      4380
     ctgggacagc tgatttatct cacggtttat gtgatacaaa tattgaaaat ttatttgtag      4440
     ttcaatcggg atctgtatca ccaaacccta cagccttgtt acaaagtaaa aattttaatg      4500
     atatgattga aacattgcgt aaatattttg attatatcat tgttgataca ccacctattg      4560
     gaattgttat tgatgcggca attatcactc aaaagtgtga tgcgtccatc ttgataacag      4620
     caacaggtga ggtgaataaa cgtgatgtcc aaaaagcgaa acaacaatta gaacaaacag      4680
     ggaaactgtt cctgggagtt gttttaaata aattggatat ctcggttgat aagtatggag      4740
     cttacggttc ctatggaaat tatggtaaaa aataacttag aaaagatttt atggatgaaa      4800
     aaggattgaa aatttttctg gcagtattgc agagtattat tgtcatttta ttgatttatt      4860
     ttcttaactt tgttagagag acagaacttg aacgttcttc gatggttata ctataccttc      4920
     tccacttttt tgtattttat tttagttcct atggtaacaa tttttttaaa agagggtacc      4980
     tagttgagtt taatagtact ataagatata tttttttctt tgcaatagct ataagtgtat      5040
     taaacctttt tatagcggaa cggtttagta tctctagaag aggaatggta tacttcttaa      5100
     ctttagaagg aatatcctta tacttgttaa atttcttagt aaaaaaatat tggaagcatg      5160
     tgttttttaa tctaaaaaat agcaagaaaa ttttactgtt aacagtaacg aaaaatatgg      5220
     aaaaagttct tgataaattg ctagaatctg atgaaccttc atggaaattg gtagcagtaa      5280
     gtgttttgga taaatctgat tttcaacatg ataaaatacc tgtaattgaa aaggaaaaaa      5340
     ttattgaatt tgcaacgcat gaagttgtgg atgaggtgtt tgtcaatctt ccaggagaga      5400
     gctacgatat tggagaaatt atctctaggt ttgagacaat ggggatagat gtaactgtaa      5460
     atcttaaagc atttgataag aattttggtc gcaataaaca aattcatgag atggtaggac      5520
     tggatgtagt cactttctct acaaattttt ataaaactag tcatgtgatt tcaaagagaa      5580
     ttctcgatat ttgtggtgcc actattggcc ttattctttt tgctatagct agtctagttt      5640
     tagttccatt gattcgtaaa gatggcggac cagctatttt tgctcaaact cgtataggga      5700
     aaaatggtcg acatttcaca ttttataaat tccgttcgat gcggatcgat gctgaagcta      5760
     tcaaagaaca gttgatggat caaaatacga tgcaaggtgg tatgtttaag atagacaatg      5820
     atcctcgtgt tacaaaaatt ggtcgcttta ttcgtaaaac cagtttggat gaattgccgc      5880
     agttttggaa tgtatttata ggagatatga gtttggtagg aacacgtcca cctacagtag      5940
     acgagtatga tcagtatact ccagaacaga aacgtcgact cagctttaaa cctgggatta      6000
     caggcttatg gcagattagt ggccgaagta aaataaccga ttttgacgct gttgtaaaat      6060
     tagatgtggc ttatattgat aattggacaa tctggaaaga tattgaaatt ttgcttaaaa      6120
     ctgttaaagt tgtatttatg agagatggag cgaagtaatt tctgtatatc catcatatta      6180
     ggagagaaat gaaaaagtca gtttatatca ttggttcaaa aggaattcct gctaagtatg      6240
     gaggatttga aacttttgtt gaaaaattaa cagccttcca acaagataag gctatccaat      6300
     attatgtagc ttgtatgcgt gaaaactctg caaaatcagg gactactgag gatgtttttg      6360
     aacataatgg tgctatctgt tataacgtcg atgttcctaa tattggtcca gcgcgagcta      6420
     tagcgtatga tatcgctgca attaacagag ctattgaaat tgccaaagaa aataaggatg      6480
     aagctccaat cttctatatt ttagcttgtc gaatcggtcc gttcatccat ggaattaaga      6540
     aaaaaatcca ggcgataggt gggactcttc tagttaatcc agatggtcac gagtggttac      6600
     gagctaagtg gagcgctcca gttcgtcgtt attggaaaat ttccgaaggt cttatggtca      6660
     aacatgcaga tcttttagtg tgtgatagta agaatattga aaaatatatc caagaagatt      6720
     atatacagta tcaacctaag acaacctata tcgcttatgg gacagataca acacgctcca      6780
     cattaaatag cagtgatgaa aaagtgcgtg cttggttcaa ggagaaaaat gtttctgaaa      6840
     acgagtatta cctagttgta ggacgttttg ttccagaaaa taattatgag tctatgatac      6900
     gtggtttctt ggcgtctagc tctaagaagg attttgtcct aatcacaaat gtagaacaga      6960
     ataaatttta taatcagcta ttagcaagta ctggatttga taaagatcca cgagtgaaat      7020
     ttgttggaac agtctacgac caagaacttc tgaagtatat tcgagaaaat gcttttgctt      7080
     acttccacgg acatgaagtt ggtggaacaa atccttcgtt acttgaagca ttagcatcca      7140
     caaagttaaa cttactactc gatgttggtt ttaaccgcga agttggggag caaagtgcga      7200
     tctattggaa aaaagatgag ctttcccaag taatcgagaa agttgaacaa tttgatgcaa      7260
     aaatgattga tgagttagat agacaatcaa atcagagaat tggggattat ttcacttggg      7320
     aaaagattgt cacagactac gagaaattat ttaaaaaatg aaaatattac attatacttt      7380
     aggatttcaa ccccagcgaa caggtggttt ggttaaatat gctgaggatt taatgataga      7440
     gcaaattgct caaggttatc aagtagctgc cttatatcca ggaagaatta agttcttttc      7500
     aaaagaaata gaaataatta aagcgacgtc aagacagttt gagtgttatg aactgcttaa      7560
     tagcttacct atggctttat ttggaggtat atccgatcca actgctttcc tgacaccttg      7620
     tgacaaaaat gtttatcgta cttttttaga aaaagtacaa cccgacatta tacatattca      7680
     ctcgtttatg ggattgcata aagaattcct cgaaattgct aaaaacttga atattagagt      7740
     ggtttttacg agccatgatt attatggatt agcacccgta cctcatttct attttaatgg      7800
     ggtggattat agtgataaaa atacaaattt aacatggaat attatgtctt ccaatgcttt      7860
     aagtgtgaaa aaactaagac tttttcaggt ttcattttat ccgactattc gtaaactttt      7920
     gaaactatta gggaaaaatc caaaatctaa aaagaattta gttattcgag atgttattga      7980
     ggagcaagat tatagtgatc ttcgatacta ttataatgag atgtttcact taatagatgg      8040
     ttatttgttt aatagtagac ttgcaaagaa ggtatatgag ataaatgaga ttaagtcagc      8100
     taatagtata gtattatcta taacaaatag ttcaattaat catcatcaga gattgacaac      8160
     tgcaaataat aaaattagag ttgcttatat tggtccagat gaagaatata aaggatattt      8220
     tgattttatt gactttgttg aaactttaga tcgagagtcc tatgaagtgg caacttatgg      8280
     ccatttacca aatgaagagt gcccttcatt cattgaacaa aaaggatatt ttactaagga      8340
     aatgattgac agtgtctatg aaaatattga tattcttatt gttccaagta agtggaagga      8400
     aacatttgga ttgataacag tagaagcatt atcctatggg gtaaatgttt tcgtgagtga      8460
     aaatgttgga tcaaaagact tgtttccaga aacacatgtt tttaaagaca aggaagattt      8520
     gttggctaaa atcatcaata atcagttgaa gaaaattccg cttaaaacga tagaagaaca      8580
     tgtagaagaa gttattggtt attacaaaca ggttagaagt aacaattaag gagaatgatt      8640
     aaagatatgt cctgtccaga aattagcgta attgtaccag tttataatgt ggaacgatat      8700
     ttaaggcagt gtatggattc attgataaat caaacttata gggattttga aataatttta      8760
     gtaaacgatg gatcaacgga ttcttctggg gttctctgtg aggattgggc aaaaaaagat      8820
     gaaagaattc atgtagttca caaaaaaaat gaggggcttg gcttcgctcg taatacaggg      8880
     gttgaacacg caaaggggaa atacataacc tttgtagatt cagatgacta tgtttctcta      8940
     gatatgctgc aaactctata taatgctgtt caagaatatg atgtcgaagt tgtatacagt      9000
     gcgggatatt atcgttcctt tagtaatggg gaaataaaga agacagatgt agaaacaaaa      9060
     aaacctcaac ttttcgaagg aggagatgtt gcctctaaat tactccctga tgtaatttct      9120
     gctcctcctg agtatccgaa tgatgggaaa gttggagtgt cggcatggaa ggttctctac      9180
     gaagctaatt tgtttaagga aaaaggctta ttatttcatt cagaaagaga attcatttca      9240
     gaagatgcta tttttcaaat tgattgttta aaattagcaa catctgccct tgttatccca      9300
     gatattttat actactatcg tgaaaacttt ggttctttaa gtatgaaata taaagaagaa      9360
     cggtttgagt tggataaaat cttgtataac gagcaattaa aaagagttga ggggttacct      9420
     aatcaagaaa ttttggaaga aagaatagag agaattttaa ttgctaatat tcgtttatgt      9480
     atctttcagg aatccttata taaaagttct agaattcata aacgtttgca aagaattaga      9540
     cagatttgta aggacccaat atcaaaatca gtattacgtc attatccaat ccatcgttta      9600
     ccttttacta aacgtttgat ctgtgtatta gctaagtata atatgtcgtt gttgctttta      9660
     gttttaacct cattaaaata tcggaatcgg agtgtgtaac ttttatgggg atgaatatag      9720
     aaaaattaaa actatctttt aaaaatggaa cgttttttcc tgttgttatt cacgccttac      9780
     gtaaccgttg gcccttgtgg tggattcgga gtaaggctat tcgagaagtg caacttgaag      9840
     atagggccta cagaatacta aaaaagaaat acggttcttt aatttcaaac tcttttgata      9900
     aatcatactt atcagaagaa gttcccaagc aaatctggat ttgctggttt caaggtatgg      9960
     agaatgctcc agagttggtg aaatcatgtt atagatcact aaaaaaacaa tttcctgaat     10020
     atgtcattac ggttatttct tcagaaaata tttccgaata tgtagaaata tctgatatta     10080
     tttataaaaa atggggaaat ggtgtaatag gaaatgctca tttttctgat atccttcggg     10140
     tagagctgtt acgtaagttt gggggaatat ggattgactc aacagtgtat tgtacaggaa     10200
     ttactaccat agagacaatt gaaaaaaata cattttttat gtataaaagt ttatattcag     10260
     ttgaggagag aatttcctct tccaactgga tgattgcttc tgttcccaat catccattta     10320
     tggttacgat gagcacactc ttgcaatctt attggtcaaa agaagttata gcaattcatt     10380
     attatctatt tcatattctt tttacgatta tgattgaatc actttctgag ttgtggcagc     10440
     ttgtacccac ctatacgaac gcaacaccac atataatggt tgatgaatta aataatgttt     10500
     tttcaaagga acgttatcag caattgtgtc aaatttcaga ttttcataaa ttaaattata     10560
     aaaaaaatta caatgataaa tcagagagtt tgtacagtca cttactgaat cagtagaggg     10620
     gagaatcttg cctaatttaa agaaaaacat tgtttacaat gtcttatatc agatcttagc     10680
     tgtaatagta ccgtttatta cctcacctta cttagcgcgt gtgttaggtg cagagcaaat     10740
     tggagtttat tcttttactt attccattgc tttttacttt atgattctgt ccatgttggg     10800
     aatttctaat tatgggaatc ggacaatagc acaggtacga acaagtagag aacatttgaa     10860
     tcaagaattt tcgaatattt acgcagttca gttgacgtgt tcactagtaa tgaccgtctc     10920
     atatttgatt tatgcaacag tatttgtgaa tagttttcag attgtagcct atatccaagt     10980
     attacatgtt ttatcgtatg caacagatgt tagttggttt ttttatggtc ttgaagagtt     11040
     tcgtattacg gttgctagga attcatttgt taagttatta actttaatat ctatctttac     11100
     atttgtaaaa agccctaatg atatctattt atataccttt ataatggcag ggagtaccct     11160
     gcttggtcag ttgattacat ggcaattttt gctaaaacaa gtaaactttg tgcgccctaa     11220
     tcttggaaaa ataaagaaac acatgaaacc tattattatt ttatttttcc ccgtcttagc     11280
     ggttagtatt ttttcgtttc tagataaaat aatgcttggg atgtatagta gtttgaagga     11340
     aactgctttt tatgagaatt cagataagat aattagtatt ccaaaagctc tgattcaagc     11400
     ctttggagct gtaatgttgc ctcgaacagt acatttactg agtataggtg atgaacaaaa     11460
     aagtttagaa tatgttgata aaacgatgtg ggttgtttta gtgattacaa tgggctgtgc     11520
     tttcggttta gcaggagttt ctgcaacctt tgctcctgtt tattggggtg aagaatttag     11580
     ggccagtagc caaattattg caggaatgac accggcttta gtattttcgg cttttggaaa     11640
     tgtcatccga acccagtttt taattccacg aagttttgac aaggaatata cggtatcttt     11700
     gctttatgga gccgtagtta atatcttgat taatattctt ttgattccga agatgggagc     11760
     aatgggagct gttatcggaa taattgttgc agagttagtt ctatgttgct atcaaacatg     11820
     gattgctaga aattatttac atatcagaga atatctgata aatgctggga tattatttct     11880
     tattggttca gtaatgtata tggttttaat tcttatttca agtattttac ctacatcgtt     11940
     acttacactt attattgaaa ttatagtcgg agctttcatt tatattagtt tactggttct     12000
     gtatatcttt tcttcaaaaa acagggtaat tattggttta cgaacaaatt ttttagaaca     12060
     tactcattta tttaaaagga aataatagtg aaatttaaat ttaatccaat cgcgatactg     12120
     tatatattgc tagtatactt agagttggct acagataggc aacatctgta tcctgtaacg     12180
     tacatgacaa aatattatat tggtatttta atcattgtgt tgtttgtttt attattagta     12240
     ggccgtggga agcttatttt tgttaataaa aaattattat atcttgctaa gatattagct     12300
     ataccaacaa ttgttctttt cctgtactca gtcttactag acgtaatgaa cccagttgaa     12360
     tttaatggat attttagtag attatcaagt acgactattt ttggtttgtt agctatcttt     12420
     caagctatag ttgtttttca attttttgga caaaaagtag tagattacac ttttacagct     12480
     atctccctca gctacttaac cagtatcatt gttgccttta ggcagggagg acttagtcaa     12540
     tttatcttga tactaacaga tgatagtttc aatggttcgg tactagaaat gcatgaagtt     12600
     gcacctatta cagctctctt tattctgtac tatttgtaca aatattttat aaaagaaaat     12660
     agtttttctt cagtatttta taatatctta atagctctca ttattctttt tttaagcctt     12720
     aaacgaatcg ttcttttgag tgtattaatt atcataccag tatttttggt aatttattgg     12780
     tatgataaaa aagtaagtaa actagggaaa gaacgaaaaa ttttaagttt attaaatatc     12840
     ttttccttaa tatttataac aggaatattc ctttatgttt atagtgtaaa atctgatttt     12900
     atatatacat ttattcaaga acataatatt aattcgatgg ctagaacaga tttatggaag     12960
     ggagttgaat caacctataa tttcgcccct atatttatgg ggagagggat agggtttgta     13020
     acaaaatgga tggataataa ttggatgact ttgaatatca atggtcttac agggacaatg     13080
     gggatccata atgatatttt gaagtactac attgagatag gatttgtagg attatttatt     13140
     tatttttaca ctcttcttta tagaaatgct aaacgtatat ttgtaaaaat tggtcataaa     13200
     gaatcattca tatattttgt attgataatg tttcagatgc tgatatggtt tacagataat     13260
     atttcaattt accataattt tttatggatc ctaaatctac tactcttttc tttaactaat     13320
     tcggatacag aattggaaaa tttagatttt aaaaattttt aatgtgtaag tagtaactac     13380
     taattttatt aaaaaatcag aatataggtg tatttatgaa gacagatgct aggactaaaa     13440
     agagagagaa tgaaacgtta tatattctaa aagtttgggc aacatttagt gtgattgcta     13500
     tacattttgg ttttttgggc caaattggag tgttttacaa agtattagct cgatttgctg     13560
     tacctttatt tttcatgatt tcaggatttt attcgtttag tatttcagaa gaaaaactga     13620
     agaaaagaat taaaaatctg agtttattga taatttccag tacaagtttt tattttttac     13680
     tggatgtttt tcttcaatta acacaaggaa atctaagagt tgtatttgaa agatttactt     13740
     ttaataatat ttttaatttt ttggtattca atcaaatttc tgctctaatt ggctcgttag     13800
     caacaccact atggttctta tatgcattac tgtatgttta tatttatcta tttttttcaa     13860
     ataaaaaatg gatatttaat actattttga ctgtgatcat actctgttgt tcatttataa     13920
     tcgagttaaa agcaaatagt gctttatttt atagaaactt cttatttatg ggagttccct     13980
     tcttttcttt tgggatgtat tttgctcaaa ttcagagaaa aattataaat tataagcact     14040
     tcaaagaact ttttataatt ggaattatga tttcaggatt tctaactctg attgaatata     14100
     cctttttagg agcaaatttt gaactttatg taagttcggt gataatatct tgtatgctta     14160
     tggtcttttc gattaaatat cctcaactct ggacgttaga ttttgctgtc aatattgcta     14220
     aaaaaaatgc gacgtttatt tatattagtc atcaatttgt gattttatta tttaaaacat     14280
     acgttagaga tggaattgct tataaaattg gaactttctt gatattttta gcatgtgtta     14340
     ttatgagtat tattttcaac tatatagtcg atataatcag tcgttgttgc ataaaagaaa     14400
     aacaagatat aatatgaaat tttatataaa aaatttatta aaaaaagtct ttacattacc     14460
     gttgcattta ttgcctattc agtctaataa gataatattt gataattttg gtggtagagg     14520
     ttttggggac aatcctaagt atatacttga agaacttgtc tctcgagaaa agaatctaga     14580
     tcttgtgtgg gtaacaaaag atagagaaat ttctatccct gaaggcgttc gagtagtaaa     14640
     atacggcagt taccgttctt tttatgaatg gttaacagct agagtttggg tagataatat     14700
     tcgtaattct gatcgacctt ggaagcgaaa aggacagatt tatcttcaaa cttggcatgg     14760
     ttcagatggg gtaaagttaa ttgaaaaaag tgttgcaggg aacctaaaaa aaacatatct     14820
     tagaatggcg aagtatgatg gaaagattac agacggtatc gtatcaagtc ggcattttca     14880
     aactttgggt atgcaaaata atttttggct ggcagagaat gtggaatttc tggaatttgg     14940
     attacctcga aatgatgatt tttttaaaag tgaaaaaatc aaaaccacaa atataaaatt     15000
     tagaacatta tttgatatcg atttagacga actggtagtt ttgtatatgc cgacgttcag     15060
     agatgatgga tcgttgaatg cctataattt agattactcg aaactaatac atgtttttca     15120
     aaataaattt agaaaaaatg taaaaatatt agttcgtttt catccaaatg ttgattctag     15180
     ttttataaat ttacaggata cagactgtat aaatgtgtcg acctattcaa atcctcagga     15240
     tctgatgatg agtgcagatg tgatgattac ggattattca tcggcttcta ttgattttat     15300
     gttattaaat cgtccagtat ttctgtattt accagattat caaagttatg tgaatgatag     15360
     accattggat gataactttg ataaattgcc atttccaaga gcatatcata acaatgagtt     15420
     gacagaaatt attagagact ttgaaagaag taaatatgat gaaaaagttc gtctgtatga     15480
     attagaggat gttcgttttg atagaggaaa agcatcagta cagtgtgcta attggattga     15540
     agaaaaaata aaaaacaata aagttattga ttgaaataat tatatttatt gaattataaa     15600
     taaggaggtc tttagatgaa aagagttata acatatggta catttgattt attgcattat     15660
     ggtcatatca atcttttgaa acgtgctaaa cagctaggtg attatttgat tgtagttgtt     15720
     tcaagtgatg agtttaattt aaaagaaaag aataaagtat gttactttaa ctacgaacac     15780
     agaaaaaatt tagtagaagc tattcgatat gtcgatttag taatccctga aactagttgg     15840
     gaacagaaaa agtcagatgt taaagactac catattgaca cttttgtaat gggtgatgat     15900
     tggaaaggta aatttgatta tcttgaagaa gaaggtgttg aagtagtcta tttgcctaga     15960
     acaaaggaaa tatcaaccac aaagataaaa gaagatttat cggaatgaaa tattattaaa     16020
     aatgctgaca taagaaattg tggcttttgt gtctagtttt tgatagaata aagtaacaac     16080
     actttaacca atgaggtgtg aataatggca gtaattttta aagatgtact tgttgaagag     16140
     aaaactgatg aagaaaaaca acatatttta tctattttaa atgatgagaa tgttagagct     16200
     tttgattgtg gatattaaga attgaatgat gttttttgat atttagaaca aatacgatga     16260
     agaaacaggc catgtattgc ctattgtaaa tcaaaatttt gaattattag gttttatttc     16320
     ttgtagacta gtatcatttt ctttcatagc tcaggttaaa gagatgggaa ttagcataga     16380
     ttatcttggt attcataagg attgccagaa aatgggggat cggttcgctt ttggtgctct     16440
     ttgcgcttcg attatcttta actattgact gttgattacc aataaaaggt gtaatagttc     16500
     atgctctaga ggatgttgta gaattctatg acaaactggg ttttattgac cctagagata     16560
     tagttattta taatggcaaa ccggttacta tatattttag tattgaaaaa ctaagaaatg     16620
     gtgaaaatta ttcctctcac acagttattt gaaacatcct tagaaaatga tttttaattg     16680
     tatgcaaaca aagtagaatt cgcttatttc atcttatgct aaatgtaata tgaaacaagt     16740
     gaatttttat agataaagaa gaattttaaa aaatgtgatg attattttta gagcagtaca     16800
     gaattaatag taattgactc taaatcaata aagaaaggta ccctattatg aaaggtatta     16860
     ttctagcagg tggttcgggg acacgtttat atcctttgac tcgagctgca tcaaaacaac     16920
     tgatgccggt ttatgataaa ccgatgattt actatccact ttcaacattg atgttggctg     16980
     ggattaggga tattttgata atctcaactc ctcaagattt gcctcgtttt aaagagcttc     17040
     ttcaagacgg atctgagttt gggattaaac tttcttatgc agagcaacca agtccagatg     17100
     gtttggcaca agcctttatc attggggaag agtttattgg tgatgatagt gttgctttga     17160
     tcttggggga caatatctat cacggccctg gtttgagcaa aatgcttcaa aaagcagcca     17220
     agaaagagaa aggtgcgact gtctttggct accatgtcaa ggatccagaa cgctttggtg     17280
     ttgtagaatt tgatgaaaat atgaatgcta tctccatcga agaaaaacca gaacagccgt     17340
     gctctaacta tgcagtgaca ggactgtatt tctatgataa cgatgttgtc gagattgcca     17400
     aaagtattaa accaagtcct cgtggtgaat tggaaattac agatgtaaac aaagcttacc     17460
     tagatcgtgg tgatttgtct gttgagctta tgggacgcgg ctttgcttgg ttggatactg     17520
     gaacacatga aagtttactg gaggcttcac agtacatcga aacagtgcaa cggatgcaaa     17580
     atgttcaggt agcaaacttg gaagaaattg cctatcgcat gggttatatc agtcgtgaag     17640
     atgtattgac cttagcccaa ccacttaaga aaaatgaata cggacagtat ctgctccgtt     17700
     tgattggaga agtctagatg acagataatt ttttcggtaa gacgcttgcg gcacgcaagg     17760
     ttgaagctat tccaggcatg ttggagtttg atatccccgt tcatggagat aatcgtggct     17820
     ggtttaaaga aaatttccaa aaggaaaaaa tgcttccact tggatttcca gagtctttct     17880
     ttgcagaagg aaaattgcaa aacaatgtat ccttctcacg taaaaatgtc cttcgaggcc     17940
     tccacgcaga gccttgggat aagtacatct ctgtagcaga tggagggaaa gttctgggtt     18000
     cttgggttga tctacgcgag ggtgaaacct ttgggaatac ctatcagaca gtaattgatg     18060
     caagcaaggg aatctttgtt cctcgtggcg tagctaatgg cttccaagtt ttatcagata     18120
     cagtgtcata tagctatctg gtcaatgatt actgggcgct tgaactcaaa cccaagtatg     18180
     cctttgtgaa ctacgctgat ccaagctttg gtattgaatg ggaaaatatt gcagaagcag     18240
     aggtttcaga agcagataaa catcatcccc tacttaagga cgtgaagcct ttgaaaaaag     18300
     aagatttgta aaaaggaaag aatatgactg aatacaaaaa tattatcgtg acaggtggag     18360
     ctggctttat cggttctaac tttgtccatt atgtttacga gaactttcca gatgttcatg     18420
     tgacagtcct agataagttg acttatgctg gaaaccgcgc gaatattgag gaagttttag     18480
     gtaatcgtgt tgagttagtt attggtgaca ttgctgatgc ggagttggta gacaagttgg     18540
     ctgctcaagc agatgctatc gttcattatg cagcggaaag ccacaatgat aattcgctca     18600
     atgatccatc gccatttatt catactaact tcatcggaac ctatactctt ttagaagctg     18660
     ctcgtaagta tgatattcgc ttccaccatg tatcgacaga tgaagtttat ggggatctcc     18720
     ctttacgcga agatttgcca ggtcatggtg aaggaccagg tgagaaattt actgctgaaa     18780
     caaaatacaa cccaagctct ccgtactcat caaccaaggc agcctcagat ttgattgtca     18840
     aagcctgggt gcgttctttt ggagtcaagg caacgatttc caactgttca aataactacg     18900
     gtccttatca acatatcgaa aaattcatcc cacgtcagat tactaacatc ctaagtggaa     18960
     ttaagccaaa actttacggt gaaggtaaga atgttcgtga ctggatccat accaatgacc     19020
     attcttcagg agtttggaca atcttgacaa aagggcaaat cggtgaaacc tacttgattg     19080
     gggctgatgg tgagaagaac aataaggaag ttttggaact tatccttaag gaaatgggac     19140
     aagctacgga tgcctatgat catgtgactg accgtgcagg acatgacctt cgctatgcga     19200
     ttgatgccag caagctccgt gatgagttgg ggtggaaacc tgaatttacc aactttgaag     19260
     ctgggctcaa ggcaacaatc aagtggtata cagataacca agaatggtgg aaagcagaaa     19320
     aagaagctgt tgaagccaat tatgctaaga ctcaggagat tattacagta taaaaagcag     19380
     gaaatagctg ctttttattg ctatattggg aagagttaca tattagaaag gtctagagat     19440
     gattttaatt acaggggcaa atggccaatt aggaacggaa cttcgctatt tattggatga     19500
     acgtaatgaa gaatacgtgg cagtagatgt ggctaagatg gacattacca atgaagaaat     19560
     ggttgagaaa gtttttgaag aggtgaaacc gactttagtc taccattgtg cagcctacac     19620
     cgctgttgat gcagcagagg atgaaggaaa agagttggac ttcgccatca atgtgacggg     19680
     gacaaaaaat gtcgcaaaag catctgaaaa gcatggtgca actctagttt atatttctac     19740
     ggactatgtc tttgacggta agaaaccagt tggacaagag tgggaagttg atgaccgacc     19800
     agatccacag acagaatatg gacgcactaa gcgtatgggg gaagagttag ttgagaagca     19860
     tgtgtctaat ttctatatta tccgtactgc ctgggtattt ggaaattatg gcaaaaactt     19920
     cgtttttacc atgcaaaatc ttgcgaaaac tcataagact ttaacagttg taaatgacca     19980
     gtacggtcgt ccgacttgga ctcgtacctt ggctgagttc atgacctacc tagctgaaaa     20040
     tcgtaaggaa tttggttatt atcatttgtc aaatgatgcg acagaagaca caacatggta     20100
     tgattttgca gttgaaattt tgaaagatac agatgtcgaa gtcaagccag tagattccag     20160
     tcaatttcca gccaaagcta aacgtccgct aaactcaacg atgagcctgg ccaaagccaa     20220
     agctactgga tttgttattc caacttggca agatgcattg caagaatttt acaaacaaga     20280
     agtgagataa gtagtagaat gattttctag tctaataaaa gaggcagata atgaactcaa     20340
     aaggagctta aggtgtacga ttatcttgtt gttggtgctg gtctctttag tgcagtcttt     20400
     gcccatgaag tagccttaaa aggaaaaaag taaaagtcat tgaaaaacgg aatcatatcg     20460
     tgggtaatat ctatactcgt gaagaggaag gaattcaagt tcatcaatat ggtgctcata     20520
     tcttccatac ttctgataag gagagctggg attatgtaaa tcagtttgca gggtttaacc     20580
     gttacaccaa ttctcctgtt gcaaactata agggtgagat ttataacctt ccttttaata     20640
     tgaatacttt caataaactc tggggagttg taacgccagc agaagcacaa gctaagattg     20700
     aggaacaacg tgctatttta aatggtaaaa ctcctgaaaa tttggaagaa caggcgattt     20760
     ctcttgtagg tacagacatc tacgaaaaat taatcaaaga ctatacagag aaacagtggg     20820
     gcaaaccaac tactgaactt ccatccttta ttattcgccg tttaccagta cacctgacct     20880
     atgataacaa ctattttaac gatacctatc aagggattcc aattggtgga tacactcaaa     20940
     tagttgaaaa atgttggatt atgaaaatat tgatgtagaa acaaatgttg atttctttgt     21000
     gaacaaagag caatatctga aagattttcc taagattgtc tttactggta tgattgatga     21060
     attctttgac tataagttgg gcgaactaga gtaccgtagt cttcgttttg aaaatgagac     21120
     cttggatatg gaaaattacc aaggaaatgc agttgtgaac tatacggatg cagaaacccc     21180
     atatactcgc attattgaac acaaacattt tgagtttggg agtcaagcaa agactatcat     21240
     tactaaagaa cattctaaaa catgggaaaa aggtgatgag ccttattatc cagttaataa     21300
     tgatcgtaat aatcatttgt ataaatcgta taaaaaattt gctgatgagc aagggaatgt     21360
     tatctttggt ggccgcttag gacactatcg ttattacgat atgcaccaag taattggagc     21420
     agctttgcag tgcgtgagaa atgagttaga ttaatactca atgaaaatca aagagcaaac     21480
     taggaagcta gccacaggtt gctcaaaata ctgttttgag gttgcagatg gaagctgacg     21540
     cggtttgaag agattttcga agagtataaa caagtaaaac tgactaccag ttattattta     21600
     gaaatagtat taaaaattcc ttgactatgt gatatagttg agggattttt aaatgatatt     21660
     catatttttt gcaaagatgt tgtttgaaaa ataattttca aaaattctga aaattctgtt     21720
     gacatctttc tgaaaagagt ttataatgga gagaaagttt taaaggagaa aatgatgaaa     21780
     agttcaaaac tacttgccct tgcgggcgtg acattattg                            21819
//